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bakhshiali authored Nov 8, 2024
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title: "Recent advancements in polyaniline-based biosensors for diagnosis of cancers: a comprehensive review"
collection: publications
permalink: /publication/18
excerpt: 'This review is about polyaniline-based nanobiosensors for setection of cancer biomarkers.'
date: 2024-11-08
venue: 'Trends in Analytical Chemistry'
paperurl: 'https://doi.org/10.1016/j.trac.2024.118040'
---
<address class="author">Authors: Mojtaba Hosseine, <a rel="author" href="https://bakhshiali.github.io">Ali Bakhshi</a>, Seyed Morteza Naghib, Navid Rabiee
</address><br>

<p align="justify" style="padding-left: 1em">
Recent advances in biosensor and bioelectronics technologies have revolutionized cancer diagnosis, providing more accessible,
sensitive, and specific methods for early detection. This review focuses on polyaniline (PANI)-based biosensors, which demonstrate
significant potential in detecting cancer biomarkers due to their tunable properties, cost-effectiveness, and ease of synthesis.
Various PANI synthesis techniques, including chemical, electrochemical, enzyme-catalyzed, vapor-phase, and template-assisted
polymerization, are examined, along with the development of multidimensional PANI nanostructures to enhance biosensor performance.
Advanced 3D printing techniques have enabled the precise fabrication of PANI-based devices, such as flexible sensors,
high-performance supercapacitors, and electroactive scaffolds, showcasing PANI's versatility and potential in biomedical
and biosensor applications. The application of PANI-based biosensors in detecting lung, liver, breast, and prostate cancers
is discussed, highlighting the detection principles, limits, and specificity for each cancer type. Furthermore, the role of
PANI in signal amplification through nanocomposite (NC) integration, which improves diagnostic accuracy, is explored.
This comprehensive review also addresses the current challenges and future opportunities for advancements in PANI-based
biosensor technology, emphasizing its critical importance in the next generation of cancer diagnostics. By overcoming the
limitations of conventional diagnostic methods, these biosensors are positioned to play a pivotal role in improving early
cancer detection and patient outcomes.
</p>
<cite> Mojtaba Hosseine, Ali Bakhshi, Seyed Morteza Naghib, Navid Rabiee
Recent advancements in polyaniline-based biosensors for diagnosis of cancers: a comprehensive review, 118040
DOI: https://doi.org/10.1016/j.trac.2024.118040
</cite>

<b>Full-Texts</b>
<details>
<summary>Sciencedirect</summary>
<a href="https://doi.org/10.1016/j.trac.2024.118040"> https://doi.org/10.1016/j.trac.2024.118040 </a>
</details>
<details>
<summary>Researchgate</summary>
<a href="https://www.researchgate.net/publication/385656766_Recent_advancements_in_polyaniline-based_biosensors_for_diagnosis_of_cancers_a_comprehensive_review"> https://www.researchgate.net/publication/385656766_Recent_advancements_in_polyaniline-based_biosensors_for_diagnosis_of_cancers_a_comprehensive_review </a>
</details>

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