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+---
+title: "A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: Critical challenges, outlooks and promises"
+collection: publications
+permalink: /publication/17
+excerpt: 'This review is about chitosan-based nanocarriers for brain diseases.'
+date: 2024-08-22
+venue: 'International Journal of Biological Macromolecules'
+paperurl: 'https://doi.org/10.1016/j.ijbiomac.2024.134962'
+---
+<address class="author">Authors: Khashayar Khodaverdi, <a rel="author" href="https://bakhshiali.github.io">Ali Bakhshi</a>, M.R. Mozafari, and Seyed Morteza Naghib
+</address><br>
+
+<p align="justify" style="padding-left: 1em">
+The administration of medicinal drugs orally or systemically limits the treatment of specific central nervous system (CNS) illnesses, 
+  such as certain types of brain cancers. These methods can lead to severe adverse reactions and inadequate transport of drugs to the 
+  brain, resulting in limited effectiveness. The CNS homeostasis is maintained by various barriers within the brain, such as the endothelial, 
+  epithelial, mesothelial, and glial barriers, which strictly control the movement of chemicals, solutes, and immune cells. Brain capillaries 
+  consist of endothelial cells (ECs) and perivascular pericytes, with pericytes playing a crucial role in maintaining the blood-brain barrier 
+  (BBB), influencing new blood vessel formation, and exhibiting secretory capabilities. This article summarizes the structural components 
+  and anatomical characteristics of the BBB. Intranasal administration, a non-invasive method, allows drugs to reach the brain by bypassing 
+  the BBB, while direct cerebral administration targets specific brain regions with high concentrations of therapeutic drugs. Technical and 
+  mechanical tools now exist to bypass the BBB, enabling the development of more potent and safer medications for neurological disorders. 
+  This review also covers clinical trials, formulations, challenges, and patents for a comprehensive perspective.
+</p>
+<cite> Khashayar Khodaverdi, Ali Bakhshi, M.R. Mozafari, and Seyed Morteza Naghib
+A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: Critical challenges, outlooks and promises, 134962
+DOI:https://doi.org/10.1016/j.ijbiomac.2024.134962
+</cite>
+
+<b>Full-Texts</b>
+<details>
+<summary>Sciencedirect</summary>
+  <a href="https://doi.org/10.1016/j.ijbiomac.2024.134962"> https://doi.org/10.1016/j.ijbiomac.2024.134962 </a>
+</details>
+<details>
+<summary>Researchgate</summary>
+  <a href="https://www.researchgate.net/publication/383292490_A_review_of_chitosan-based_nanocarriers_as_drug_delivery_systems_for_brain_diseases_Critical_challenges_outlooks_and_promises"> https://www.researchgate.net/publication/383292490_A_review_of_chitosan-based_nanocarriers_as_drug_delivery_systems_for_brain_diseases_Critical_challenges_outlooks_and_promises </a>
+</details>