R code for the paper "Testing One Primary and Two Secondary Endpoints in a Two-Stage Group Sequential Trial with Extensions"

Files included

util.R: R code containing functions for group sequential designs. Requires the mvtnorm package.

bonferroni.R: R code containing functions for Bonferroni-based normal theory boundaries.

bonferroni_grid_search.R: R code containing functions for the grid search of optimal boundaries for Bonferroni-based normal theory boundaries. The current code is configured for the computing instances on AWS.

simes.R: R code containing functions for Simes-based normal theory boundaries.

simes_grid_search.R: R code containing functions for the grid search of optimal boundaries for Simes-based normal theory boundaries. The current code is configured for the computing instances on AWS.