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rhalperin authored Aug 3, 2018
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## Overview
Running lumosVar involves two main steps
1. normalMetrics: analyzes a set of unmatched controls to find average read depths and position quality metrics
- IMPORTANT - unmatched controls must be generated using the same exome capture as the tumors
1. normalMetrics: analyzes a set of unmatched controls to find average read depths and position quality metrics.
**IMPORTANT - unmatched controls must be generated using the same exome capture as the tumors**
2. lumosVarMain: call somatic, germline, and copy number variants

### Example dataset
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```
- The bamList file should contain absolue paths to the tumor bams with one per line. All of the bams should come from the same patient.

It is important that the length of priorF matches the number of bams in the bam list. We recommend the following values for priorF:
- solid tumor: 0.7
- purified tumor or cell line: 0.99
- tumor adjacent normal tissue: 0.1
- normal tissue unlikely to have tumor contamination: 0.01 (you may also set NormalSample to the indicate postion of your normal sample in your bam list file to run in matched normal mode)
- It is important that the length of priorF matches the number of bams in the bam list. We recommend the following values for priorF:
- solid tumor: 0.7
- purified tumor or cell line: 0.99
- tumor adjacent normal tissue: 0.1
- normal tissue unlikely to have tumor contamination: 0.01 (you may also set NormalSample to the indicate postion of your normal sample in your bam list file to run in matched normal mode)

To run lumosVar
```
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