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Recurate cox2016 #199

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d1f3ee0
recurate cox2016
ewollert May 3, 2019
de62ece
Update cox2016.bel
cthoyt May 5, 2019
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117 changes: 90 additions & 27 deletions hbp_knowledge/tau/cox2016.bel
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Expand Up @@ -6,8 +6,8 @@ SET DOCUMENT Licenses = "CC BY 4.0"
SET DOCUMENT ContactInfo = "[email protected]"

SET DOCUMENT Name = "Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition"
SET DOCUMENT Version = "1.0.1"
SET DOCUMENT Authors = "Sandra Spalek"
SET DOCUMENT Version = "1.0.2"
SET DOCUMENT Authors = "Sandra Spalek, Esther Wollert"
SET DOCUMENT Description = ""

##############
Expand Down Expand Up @@ -77,26 +77,35 @@ SET Citation = {"PubMed", "27574109"}
SET Evidence = "Right angle laser light scattering showed significantly greater scattered light
intensity in all 4R tau isoforms when compared to 3R isoforms (one-way ANOVA with Holm-Sidak
post-hoc, F(5, 18) = 60.22, p < 0.0001; Fig. 2A)"
a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
SET Confidence = "Medium"
a(HBP:"4R tau") -> path(MESH:"Protein Aggregation, Pathological")
UNSET Confidence

SET Evidence = "hT40 showed the highest amount of light scattering compared to
other 4R isoforms, and there were no differences between the different 3R isoforms"
a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
SET Confidence = "Medium"
a(HBP:"Tau isoform F (441 aa)") -> path(MESH:"Protein Aggregation, Pathological")
UNSET Confidence

SET Evidence = "Similar results were seen in the ThS assay, where the 4R isoforms were
significantly higher than 3R isoforms (one-way ANOVA with Holm-Sidak
post-hoc, F(5, 18) = 19.99, p < 0.0001; Fig. 2B), and no differences were
found in comparisons between the individual 4R isoforms or between the 3R isoforms"
a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
SET Confidence = "Medium"
#ThS assay for determination of extent of aggregation
a(HBP:"4R tau") -> path(MESH:"Protein Aggregation, Pathological")
UNSET Confidence

SET Evidence = "A mixture of long, intermediate and short filaments, as well as globular
oligomers were present in 4R isoform reactions (Fig. 2C–E)"
a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization")
SET Confidence = "Medium"
a(HBP:"4R tau") -> bp(GO:"positive regulation of protein oligomerization")
UNSET Confidence

SET Evidence ="In contrast, 3R isoforms were primarily composed of globular oligomers and only very rare long filaments were found (Fig. 2F–H)"
a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization")
SET Confidence = "Medium"
a(HBP:"3R tau") -> bp(GO:"positive regulation of protein oligomerization")
UNSET Confidence

# PAD exposure (TNT1 reactivity)

Expand All @@ -105,205 +114,259 @@ than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18
# Tau isoform D (383 aa): htau24
# Tau isoform C (410 aa): htau39
# Tau isoform Fetal-tau (352 aa): htau23
SET Confidence = "Low"
#comparison: determination of the levels of PAD exposure
a(HBP:"Tau isoform Fetal-tau (352 aa)") -- a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform D (383 aa)") -- a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform C (410 aa)") -- a(HBP:"phosphatase-activating domain")
UNSET Confidence

SET Evidence = "The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to
hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001)"
# Tau isoform Fetal-tau (352 aa): htau40
# Tau isoform B (381 aa): htau37
SET Confidence = "Low"
#to discuss: exposure = increase in domain?
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
UNSET Confidence

SET Evidence = "Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared
to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029)"
# 6 isoforms: hT40, hT34, hT24, hT39, hT37, hT23
# HBP:"Tau isoform E (412 aa)": htau34
SET Confidence = "Low"
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
UNSET Confidence

# determine the levels of tau oligomers (TOC1 reactivity)

SET Evidence = "Comparisons between isoform monomers showed that hT39 monomer signal was
significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.6, p = 0.0023)"
SET Confidence = "High"
a(HBP:"Tau isoform C (410 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform D (383 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform Fetal-tau (352 aa)") -> a(HBP:"Tau oligomers")
UNSET Confidence

SET Evidence = "The hT24 aggregates showed the highest TOC1 signal, which reached significance compared to
hT40, hT39, hT37 and hT23 aggregates, while hT34 aggregates were significantly different from hT39, hT37 and
hT23 aggregates, and both hT40 and hT39 aggregates are significantly higher than hT37 and hT23
(one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 50.77, p < 0.0001)"
SET Confidence = "High"
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
UNSET Confidence

SET Evidence = "Aggregated samples for all six isoforms showed significant increases in TOC1 reactivity
when compared to their respective monomer samples (Fig. 3B; Mann-Whitney tests, for all comparisons p = 0.029)"
SET Confidence = "High"
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
UNSET Confidence

SET Evidence = "As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity
for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally
accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H)"
SET Confidence = "High"
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform D (383 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform C (410 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform Fetal-tau (352 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform B (381 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform F (441 aa)") -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) -> a(HBP:"Tau oligomers")
a(HBP:"Tau isoform E (412 aa)") -> a(HBP:"Tau oligomers")
SET Confidence = "Low"
a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
UNSET Confidence

# effect of isoform-specific tau aggregates on fast axonal transport

SET MeSHAnatomy = {"Axons","Cytoplasm"}

SET Evidence = "Perfusion of hT40, hT34 and hT24 aggregates into squid axoplasms
significantly impaired anterograde transport (Fig. 4A) when compared to the respective monomers (all at 2 μM)."
SET Confidence = "High"
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
UNSET Confidence

SET Evidence = "Similarly, perfusion of squid axoplasms with hT39, hT37 and hT23 aggregates significantly
impaired anterograde FAT (Fig. 4A) when compared to the respective monomers (all at 2 μM)"
SET Confidence = "High"
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
UNSET Confidence

UNSET MeSHAnatomy

SET Evidence = "Pairwise comparisons within tau species showed that hT24 aggregates produced
significantly more inhibition of anterograde FAT when compared to hT34 and hT39 aggregates."
SET Confidence = "Medium"
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"anterograde axonal transport")
UNSET Confidence

SET Evidence = "hT40, hT34, hT24, hT37 and hT23 aggregates did not significantly impair retrograde FAT
when compared to the respective monomers, but hT39 aggregates elicited a mild inhibitory effect on retrograde FAT (Fig. 4B)"
SET Confidence = "High"
p(HBP:"Tau isoform C (410 aa)",pmod(HBP:"protein aggregation")) -| bp(GO:"retrograde axonal transport")
p(HBP:"Tau isoform F (441 aa)",pmod(HBP:"protein aggregation")) cnc bp(GO:"retrograde axonal transport")
p(HBP:"Tau isoform E (412 aa)",pmod(HBP:"protein aggregation")) cnc bp(GO:"retrograde axonal transport")
p(HBP:"Tau isoform D (383 aa)",pmod(HBP:"protein aggregation")) cnc bp(GO:"retrograde axonal transport")
p(HBP:"Tau isoform B (381 aa)",pmod(HBP:"protein aggregation")) cnc bp(GO:"retrograde axonal transport")
p(HBP:"Tau isoform Fetal-tau (352 aa)",pmod(HBP:"protein aggregation")) cnc bp(GO:"retrograde axonal transport")
UNSET Confidence

SET Evidence = "Collectively, these studies indicate that inhibition of anterograde FAT represents a toxic effect common
to all tau aggregates, regardless of isoform composition"
SET Confidence = "High"
a(HBP:"Tau aggregates") -| bp(GO:"anterograde axonal transport")
UNSET Confidence

# antibodies: TNT1 (PAD exposure), TOC1 (tau oligomers) and R1 (pan-tau marker)

SET MeSHAnatomy = "Hippocampus"

SET Evidence = "Indeed, early pre-tangle neurons within the hippocampus were labeled with
all antibodies in Braak I-II cases (Fig. 5A–D)"
a(HBP:pretangles) -- a(HBP:"Tau oligomers")
SET Confidence = "Medium"
a(HBP:pretangles) pos a(HBP:"Tau oligomers")
a(HBP:pretangles) pos p(HGNC:MAPT)
a(HBP:"Braak_Stage I") pos a(HBP:"Tau oligomers")
a(HBP:"Braak_Stage I") pos p(HGNC:MAPT)
a(HBP:"Braak_Stage II") pos a(HBP:"Tau oligomers")
a(HBP:"Braak_Stage II") pos p(HGNC:MAPT)
SET Confidence = "Low"
a(HBP:pretangles) -- a(HBP:"phosphatase-activating domain")
a(HBP:pretangles) -- p(HGNC:MAPT)
a(HBP:"Braak_Stage I") -- a(HBP:"Tau oligomers")
a(HBP:"Braak_Stage I") -- a(HBP:"phosphatase-activating domain")
a(HBP:"Braak_Stage I") -- p(HGNC:MAPT)
a(HBP:"Braak_Stage II") -- a(HBP:"Tau oligomers")
a(HBP:"Braak_Stage II") -- a(HBP:"phosphatase-activating domain")
a(HBP:"Braak_Stage II") -- p(HGNC:MAPT)
UNSET Confidence



SET Evidence = "In severe AD cases (i.e. Braak stage V-VI), all markers continue to colocalize in classic NFTs within the
hippocampus that characterize AD tau pathology (Fig. 5E–H)"
SET Confidence = "High"
SET MeSHDisease = "Alzheimer Disease"
a(MESH:"Neurofibrillary Tangles") -- a(HBP:"Tau oligomers")
a(MESH:"Neurofibrillary Tangles") -- a(HBP:"phosphatase-activating domain")
a(MESH:"Neurofibrillary Tangles") -- p(HGNC:MAPT)
SET Confidence = "Low"
a(MESH:"Neurofibrillary Tangles") -- a(HBP:"phosphatase-activating domain")
UNSET Confidence

UNSET MeSHDisease

SET MeSHAnatomy = "Frontal Lobe"

SET Evidence = "In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive
co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L)."
SET Confidence = "High"
a(HBP:"Corticobasal Degeneration") -- a(HBP:"Tau oligomers")
a(HBP:"Corticobasal Degeneration") -- a(HBP:"phosphatase-activating domain")
a(HBP:"Corticobasal Degeneration") -- p(HGNC:MAPT)
UNSET Confidence

SET Evidence = "Similarly, the characteristic Pick bodies in the frontal cortex were well labeled by TNT1, TOC1 and R1 in PiD tissue (Fig. 5M–P)"
SET Confidence = "High"
SET MeSHDisease = "Pick Disease of the Brain"
a(GO:"Pick body") -- a(HBP:"Tau oligomers")
a(GO:"Pick body") -- a(HBP:"phosphatase-activating domain")
a(GO:"Pick body") -- p(HGNC:MAPT)
UNSET MeSHDisease
UNSET Confidence

UNSET MeSHAnatomy

SET Evidence = "In general, the remarkable co-localization between TNT1, TOC1 and R1 in all tauopathies confirms that
PAD exposure and tau oligomerization occur simultaneously in cells displaying tau pathology, irrespective of isoform composition"
SET Confidence = "Medium"
path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers")
path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain")
path(MESH:Tauopathies) -- a(HBP:"phosphatase-activating domain")
UNSET Confidence

SET Evidence = "The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly
contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms"
SET Confidence = "High"
path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"3R tau")
path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"4R tau")
path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau")
path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau")
a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau")
UNSET Confidence

SET Evidence = "Total tau levels in the soluble fractions were similar for AD, CBD and PiD, as
indicated by the Tau5 sandwich ELISA (Fig. 6B; one-way ANOVA, F(2,9) = 3.283, p = 0.085)"
SET Confidence = "Low"
#not what said in the evidence
path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT)
a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT)
UNSET Confidence

SET Evidence = "In contrast, AD soluble tau displayed the highest level of TNT1 followed
by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002)."
path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"phosphatase-activating domain")
path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain")
a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain")
SET Confidence = "Medium"
path(MESH:"Alzheimer Disease") -- a(HBP:"phosphatase-activating domain")
path(MESH:"Pick Disease of the Brain") -- a(HBP:"phosphatase-activating domain")
a(HBP:"Corticobasal Degeneration") -- a(HBP:"phosphatase-activating domain")
UNSET Confidence

SET Evidence = "Similarly, the soluble fraction from AD contained the greatest level of TOC1 reactivity, followed by CBD
and then PiD had the lowest signal (Fig. 6D; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 16.57, p = 0.001)"
SET Confidence = "High"
path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers")
a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers")
UNSET Confidence

SET Evidence = "Total tau levels in the insoluble fractions, as detected by Tau5, were highest in AD, followed by
CBD and PiD contained the least (Fig. 6E; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 25.93, p = 0.0002)"
SET Confidence = "High"
path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT)
a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT)
UNSET Confidence

SET Evidence = "TNT1 detected significantly more PAD exposed tau in AD compared to PiD, and more in CBD when compared to
PiD, but AD and CBD were not different (Fig. 6F; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 12.07, p = 0.0028)"
SET Confidence = "Low"
path(MESH:"Alzheimer Disease") positiveCorrelation composite(p(HGNC:MAPT),a(HBP:"phosphatase-activating domain"))
path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(p(HGNC:MAPT),a(HBP:"phosphatase-activating domain"))
a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(p(HGNC:MAPT),a(HBP:"phosphatase-activating domain"))
UNSET Confidence

SET Evidence = "TOC1 detected significantly more oligomeric tau in AD compared to CBD and PiD and more in
CBD compared to PiD (Fig. 6G; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 35.32, p < 0.0001)"
SET Confidence = "High"
path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers")
a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers")
UNSET Confidence