This repository contains scripts used to produce the results presented in our manuscript titled "Association of a Common Genetic Variant with Parkinson’s Disease is Propagated through Microglia".
- Single nuclei RNA sequencing of human frontal cortex
- Single cell RNA sequencing of iPSC-derived microglia
- Target mRNA and protein expression in iPSC-derived microglia
- Single nuclei ATAC sequencing of human frontal cortex
- Single nuclei Multiome (GEX + ATAC) sequencing of human substantia nigra
- Also analysis of publicly available human substantia nigra snRNAseq datasets
- Bulk ATAC sequencing of iPSC-derived cells
- Also integration of bulk ATACseq and snATACseq datasets
- Single cell CRISPRi screen in iPSC-derived microglia targeting LRRK2 CREs