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fix error in spreadsheet, update DOI, JSON
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mmayers12 committed Oct 22, 2019
1 parent a25cd68 commit bd51679
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16 changes: 7 additions & 9 deletions README.md
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# Indication Mechanism of Action Database
A database of paths that represent the mechanism of action from a drug to a disease in an indication.

> [**Database of mechanism of action paths for selected drug-disease indications**](https://zenodo.org/record/3515487)
> [**Database of mechanism of action paths for selected drug-disease indications**](https://zenodo.org/record/3516335)
<br><Small>Mayers, Michael; Steinecke, Dylan; Su, Andrew I.<small><br>

[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.3515518.svg)](https://doi.org/10.5281/zenodo.3515518)

[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.3516335.svg)](https://doi.org/10.5281/zenodo.3516335)

## Purpose

Expand All @@ -17,13 +15,13 @@ as a path through a network of biomedical entities.

## Curation

Indications were selected at random from the set contained within DrugCentral. Half were taken from the full set,
Indications were selected at random from the set contained within DrugCentral. Half were taken from the full set,
representing a set of common drug disease pairs, and the other half were selected from a pool of less-common diseases
to vary the targets and diseases treated.
to vary the targets and diseases treated.

Paths were derived from free-text descriptions found on DrugBank, Wikipeida and within literature. Concepts within the
Paths were derived from free-text descriptions found on DrugBank, Wikipeida and within literature. Concepts within the
text were then normalized to a concept type (Drug, Protein, Pathway, etc) and relationships between the concepts were
determined from the source. Finally concepts were mapped to an identifier depending on the concept type according to
determined from the source. Finally concepts were mapped to an identifier depending on the concept type according to
the following table:

|Concept Type | Identifier Source|
Expand All @@ -38,7 +36,7 @@ the following table:
|Drug | MESH, DrugBank |
|Molecular Function | GO |
|Pathway | REACT |
|Phenotype | HP |
|Phenotype | HP |
|Protein | UniProt |
|Protein Family | InterPro |
|Taxon | NCBITaxon |
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12 changes: 1 addition & 11 deletions indication_paths.json
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"id": "MESH:D010146",
"name": "Pain",
"label": "Disease"
},
{
"id": null,
"name": "Pain",
"label": null
}
],
"links": [
Expand All @@ -3091,11 +3086,6 @@
"source": "GO:0019233 ",
"target": "MESH:D010146",
"key": "CAUSES"
},
{
"source": "MESH:D010146",
"target": null,
"key": null
}
]
},
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}
]
}
]
]
2 changes: 1 addition & 1 deletion xls_to_json.py
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from biothings_client import get_client
mg = get_client('gene')

file_location = "https://zenodo.org/record/3515518/files/indication_MOA_paths.xlsx?download=1"
file_location = "https://zenodo.org/record/3516335/files/indication_MOA_paths.xlsx?download=1"
all_sheets = pd.read_excel(file_location, None)

# Dereference each sheet into an individual variable
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