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diff --git a/@export/models.d.ts b/@export/models.d.ts
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+// export R# package module type define for javascript/typescript language
+//
+//    imports "models" from "biocad_registry";
+//
+// ref=biocad_registry.models@biocad_registry, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null
+
+/**
+*/
+declare namespace models {
+   /**
+   */
+   function enzyme(biocad_registry: object, ec_number: string): any;
+   /**
+     * @param env default value Is ``null``.
+   */
+   function enzyme_function(biocad_registry: object, enzyme_id: string, ec_number: string, metabolites: any, env?: object): any;
+   /**
+   */
+   function subcellular_location(biocad_registry: object, name: string, topology: string): object;
+   /**
+     * @param desc default value Is ``''``.
+   */
+   function vocabulary_id(biocad_registry: object, term: string, category: string, desc?: string): object;
+}
diff --git a/man/biocad_registry/models/models.md b/man/biocad_registry/models/models.md
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+# models
+
+
+
++ [vocabulary_id](models/vocabulary_id.1) 
++ [subcellular_location](models/subcellular_location.1) 
++ [enzyme_function](models/enzyme_function.1) 
++ [enzyme](models/enzyme.1) 
diff --git a/man/biocad_registry/models/models/enzyme.1 b/man/biocad_registry/models/models/enzyme.1
@@ -0,0 +1,13 @@
+.\" man page create by R# package system.
+.TH MODELS 1 2000-Jan "enzyme" "enzyme"
+.SH NAME
+enzyme \- 
+.SH SYNOPSIS
+\fIenzyme(\fBbiocad_registry\fR as <generic> biocad_registry, 
+\fBec_number\fR as string);\fR
+.SH SEE ALSO
+models
+.SH FILES
+.PP
+biocad_registry.dll
+.PP
diff --git a/man/biocad_registry/models/models/enzyme_function.1 b/man/biocad_registry/models/models/enzyme_function.1
@@ -0,0 +1,16 @@
+.\" man page create by R# package system.
+.TH MODELS 1 2000-Jan "enzyme_function" "enzyme_function"
+.SH NAME
+enzyme_function \- 
+.SH SYNOPSIS
+\fIenzyme_function(\fBbiocad_registry\fR as <generic> biocad_registry, 
+\fBenzyme_id\fR as string, 
+\fBec_number\fR as string, 
+\fBmetabolites\fR as any, 
+[\fB<Environment>\fR]);\fR
+.SH SEE ALSO
+models
+.SH FILES
+.PP
+biocad_registry.dll
+.PP
diff --git a/man/biocad_registry/models/models/subcellular_location.1 b/man/biocad_registry/models/models/subcellular_location.1
@@ -0,0 +1,14 @@
+.\" man page create by R# package system.
+.TH MODELS 1 2000-Jan "subcellular_location" "subcellular_location"
+.SH NAME
+subcellular_location \- 
+.SH SYNOPSIS
+\fIsubcellular_location(\fBbiocad_registry\fR as <generic> biocad_registry, 
+\fBname\fR as string, 
+\fBtopology\fR as string);\fR
+.SH SEE ALSO
+models
+.SH FILES
+.PP
+biocad_registry.dll
+.PP
diff --git a/man/biocad_registry/models/models/vocabulary_id.1 b/man/biocad_registry/models/models/vocabulary_id.1
@@ -0,0 +1,15 @@
+.\" man page create by R# package system.
+.TH MODELS 1 2000-Jan "vocabulary_id" "vocabulary_id"
+.SH NAME
+vocabulary_id \- 
+.SH SYNOPSIS
+\fIvocabulary_id(\fBbiocad_registry\fR as <generic> biocad_registry, 
+\fBterm\fR as string, 
+\fBcategory\fR as string, 
+\fBdesc\fR as string = "");\fR
+.SH SEE ALSO
+models
+.SH FILES
+.PP
+biocad_registry.dll
+.PP
diff --git a/vignettes/biocad_registry/models.html b/vignettes/biocad_registry/models.html
@@ -0,0 +1,178 @@
+<!DOCTYPE html><html lang="zh-CN">
+  <head>
+    <meta http-equiv="content-type" content="text/html; charset=UTF-8" />
+    <meta http-equiv="X-UA-Compatible" content="IE=Edge" />
+    <meta charset="utf-8" />
+    <meta name="viewport" content="width=device-width, minimum-scale=1.0, maximum-scale=1.0" />
+    <title>models</title>
+    <meta name="author" content="[email protected]" />
+    <meta name="copyright" content="SMRUCC genomics Copyright (c) 2022" />
+    <meta name="keywords" content="R#; models; biocad_registry" />
+    <meta name="generator" content="https://github.com/rsharp-lang" />
+    <meta name="theme-color" content="#333" />
+    <meta name="description" content="..." />
+    <meta class="foundation-data-attribute-namespace" />
+    <meta class="foundation-mq-xxlarge" />
+    <meta class="foundation-mq-xlarge" />
+    <meta class="foundation-mq-large" />
+    <meta class="foundation-mq-medium" />
+    <meta class="foundation-mq-small" />
+    <meta class="foundation-mq-topbar" />
+    <style>
+
+.table-three-line {
+border-collapse:collapse; /* 关键属性：合并表格内外边框(其实表格边框有2px，外面1px，里面还有1px哦) */
+border:solid #000000; /* 设置边框属性；样式(solid=实线)、颜色(#999=灰) */
+border-width:2px 0 2px 0px; /* 设置边框状粗细：上 右 下 左 = 对应：1px 0 0 1px */
+}
+.left-1{
+    border:solid #000000;border-width:1px 1px 2px 0px;padding:2px;
+    font-weight:bolder;
+}
+.right-1{
+    border:solid #000000;border-width:1px 0px 2px 1px;padding:2px;
+    font-weight:bolder;
+}
+.mid-1{
+    border:solid #000000;border-width:1px 1px 2px 1px;padding:2px;
+    font-weight:bolder;
+}
+.left{
+    border:solid #000000;border-width:1px 1px 1px 0px;padding:2px;
+}
+.right{
+    border:solid #000000;border-width:1px 0px 1px 1px;padding:2px;
+}
+.mid{
+    border:solid #000000;border-width:1px 1px 1px 1px;padding:2px;
+}
+table caption {font-size:14px;font-weight:bolder;}
+</style>
+  </head>
+  <body>
+    <table width="100%" summary="page for {models}">
+      <tbody>
+        <tr>
+          <td>{models}</td>
+          <td style="text-align: right;">R# Documentation</td>
+        </tr>
+      </tbody>
+    </table>
+    <h1>models</h1>
+    <hr />
+    <p style="     font-size: 1.125em;     line-height: .8em;     margin-left: 0.5%;     background-color: #fbfbfb;     padding: 24px; ">
+      <code>
+        <span style="color: blue;">require</span>(<span style="color: black; font-weight: bold;">CellRender</span>);
+                               <br /><br /><span style="color: green;">{$desc_comments}</span><br /><span style="color: blue;">imports</span><span style="color: brown"> "models"</span><span style="color: blue;"> from</span><span style="color: brown"> "biocad_registry"</span>;
+                           </code>
+    </p>
+    <p></p>
+    <blockquote>
+      <p style="font-style: italic; font-size: 0.9em;">
+
+                           </p>
+    </blockquote>
+    <div id="main-wrapper">
+      <table class="table-three-line" style="display: block">
+        <caption>.NET clr type export</caption>
+        <tbody><tr>
+  <td id="reaction_node">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/reaction.html">reaction_node: reaction</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="reaction_graph">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/reaction_graph.html">reaction_graph: reaction_graph</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="molecules">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/molecule.html">molecules: molecule</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="dblinks">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/db_xrefs.html">dblinks: db_xrefs</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="subcellular_compartments">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/subcellular_compartments.html">subcellular_compartments: subcellular_compartments</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="subcellular_locations">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/subcellular_location.html">subcellular_locations: subcellular_location</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="vocabulary">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/vocabulary.html">vocabulary: vocabulary</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="pathway">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/pathway.html">pathway: pathway</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="complex">
+    <a href="/vignettes/clr/biocad_registry/biocad_registryModel/complex.html">complex: complex</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="biocad_registry">
+    <a href="/vignettes/clr/biocad_registry/biocad_registry.html">biocad_registry: biocad_registry</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="cad_registry">
+    <a href="/vignettes/clr/biocad_registry/biocad_registry.html">cad_registry: biocad_registry</a>
+  </td>
+  <td></td>
+</tr></tbody>
+      </table>
+      <br />
+      <br />
+      <table class="table-three-line">
+        <caption>.NET clr function exports</caption>
+        <tbody><tr>
+  <td id="vocabulary_id">
+    <a href="./models/vocabulary_id.html">vocabulary_id</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="subcellular_location">
+    <a href="./models/subcellular_location.html">subcellular_location</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="enzyme_function">
+    <a href="./models/enzyme_function.html">enzyme_function</a>
+  </td>
+  <td></td>
+</tr>
+<tr>
+  <td id="enzyme">
+    <a href="./models/enzyme.html">enzyme</a>
+  </td>
+  <td></td>
+</tr></tbody>
+      </table>
+    </div>
+    <hr />
+    <div style="text-align: center;">[<a href="../index.html">Document Index</a>]</div>
+  </body>
+</html>
diff --git a/vignettes/biocad_registry/models/enzyme.html b/vignettes/biocad_registry/models/enzyme.html
@@ -0,0 +1,67 @@
+<!DOCTYPE html>
+<html>
+
+<head>
+    <title>enzyme</title>
+    <meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
+    <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes" />
+    <link rel="stylesheet" type="text/css" href="../../_assets/page.css">
+</head>
+
+<body>
+    <div class="container">
+
+        <table style="width: 100%;">
+            <tr>
+                <td>enzyme {models}</td>
+                <td style="text-align: right;">R Documentation</td>
+            </tr>
+        </table>
+
+        <h2>enzyme</h2>
+
+        <h3>Description</h3>
+
+        enzyme
+
+        <h3>Usage</h3>
+
+        <div style="width: 100%; padding-left: 3%; color: black;">
+            <pre><code class='language-R' style="color: black; font-weight:normal;"><strong>enzyme</strong>(<i>biocad.registry</i>, <i>ec.number</i>);</code></pre>
+        </div>
+
+        <h3>Arguments</h3>
+
+        <table>
+
+        </table>
+
+
+        <h3 style="display: none;">Details</h3>
+
+
+
+        <h3 style="display: block">Authors</h3>
+
+        biocad_registry
+
+        <h3>Value</h3>
+
+        this function returns data object of type <i>any</i> kind.<h4>clr value class</h4><ul><li><i>any</i> kind</li></ul>
+
+        <h3 style="display: none;">Examples</h3>
+
+
+
+        <hr />
+        <div style="text-align: center;">[Package <em>models</em> version 1.0.0.0 <a
+                href="../models.html">Index</a>]
+        </div>
+    </div>
+</body>
+
+<script type="text/javascript" src="../../_assets/R_syntax.js"></script>
+<script type="text/javascript" src="../../_assets/highlights.js"></script>
+<script type="text/javascript">r_highlights("example_r");</script>
+
+</html>