diff --git a/config/default/tox-testenv.j2 b/config/default/tox-testenv.j2
index 80361cc..ee9482d 100644
--- a/config/default/tox-testenv.j2
+++ b/config/default/tox-testenv.j2
@@ -54,3 +54,11 @@ extras =
 {% for line in testenv_additional %}
 %(line)s
 {% endfor %}
+
+[testenv:setuptools-latest]
+basepython = python3
+deps =
+    git+https://github.com/pypa/setuptools.git\#egg=setuptools
+{% for line in testenv_deps %}
+    %(line)s
+{% endfor %}
diff --git a/config/toolkit/tox.ini.j2 b/config/toolkit/tox.ini.j2
index 8e01c44..c27cbfa 100644
--- a/config/toolkit/tox.ini.j2
+++ b/config/toolkit/tox.ini.j2
@@ -37,6 +37,16 @@ commands =
 {% for line in testenv_additional %}
 %(line)s
 {% endfor %}
+
+[testenv:setuptools-latest]
+basepython = python3
+deps =
+    git+https://github.com/pypa/setuptools.git\#egg=setuptools
+    zc.buildout >= 3.1
+    wheel > 0.37
+{% for line in testenv_deps %}
+    %(line)s
+{% endfor %}
 {% include 'tox-lint.j2' %}
 {% if with_docs %}
 
diff --git a/config/zope-product/tox.ini.j2 b/config/zope-product/tox.ini.j2
index fb5e8f6..786200f 100644
--- a/config/zope-product/tox.ini.j2
+++ b/config/zope-product/tox.ini.j2
@@ -38,6 +38,16 @@ commands =
 %(line)s
 {% endfor %}
 
+[testenv:setuptools-latest]
+basepython = python3
+deps =
+    git+https://github.com/pypa/setuptools.git\#egg=setuptools
+    zc.buildout >= 3.1
+    wheel > 0.37
+{% for line in testenv_deps %}
+    %(line)s
+{% endfor %}
+
 {% include 'tox-lint.j2' %}
 {% include 'tox-docs.j2' %}