diff --git a/mpsl/CHANGELOG.rst b/mpsl/CHANGELOG.rst
index 7e8a736403..82dd5a7851 100644
--- a/mpsl/CHANGELOG.rst
+++ b/mpsl/CHANGELOG.rst
@@ -15,6 +15,7 @@ All the notable changes included in the main branch are documented in this secti
 Changes
 =======
 
+* Removed support for running MPSL on the nRF5340 PDK (DRGN-15174).
 * Timeslot API values ``MPSL_TIMESLOT_DISTANCE_MAX_US`` and ``MPSL_TIMESLOT_EARLIEST_TIMEOUT_MAX_US`` increased to 256 seconds (DRGN-16800).
 
 Bug fixes
diff --git a/mpsl/include/protocol/mpsl_cx_protocol_api.h b/mpsl/include/protocol/mpsl_cx_protocol_api.h
index 0d6d49427a..8f4cbc7ba2 100644
--- a/mpsl/include/protocol/mpsl_cx_protocol_api.h
+++ b/mpsl/include/protocol/mpsl_cx_protocol_api.h
@@ -186,8 +186,9 @@ uint32_t mpsl_cx_req_grant_delay_get(void);
 /**
  * @brief Register callback function called when radio operations granted by PTA change.
  *
- * This function is used by radio protocols that require CPU processing when granted operations.
- * One example is protocol waiting with asynchronous transmission until TX operation is granted.
+ * This function is used by radio protocols that require CPU processing when list of granted
+ * operations changes. One example is a protocol waiting with asynchronous transmission until TX
+ * operation is granted.
  *
  * When radio protocol stops using Coexistence interface to hand it over to another protocol,
  * it shall reset callback by calling this function with NULL value passed in @p cb.
diff --git a/mpsl/lib/cortex-m33+nodsp/soft-float/libmpsl.a b/mpsl/lib/cortex-m33+nodsp/soft-float/libmpsl.a
index 568433b684..b5e5f20e9d 100644
Binary files a/mpsl/lib/cortex-m33+nodsp/soft-float/libmpsl.a and b/mpsl/lib/cortex-m33+nodsp/soft-float/libmpsl.a differ
diff --git a/mpsl/lib/cortex-m33+nodsp/soft-float/manifest.yaml b/mpsl/lib/cortex-m33+nodsp/soft-float/manifest.yaml
index 9f0dc8ffc6..5b9501e4fb 100644
--- a/mpsl/lib/cortex-m33+nodsp/soft-float/manifest.yaml
+++ b/mpsl/lib/cortex-m33+nodsp/soft-float/manifest.yaml
@@ -1,3 +1,3 @@
 description: Multi-Protocol Service Layer (MPSL)
-git_revision: 7ae19e799ec1b949d7614b906c21ead36f7fa18f
-timestamp: '2022-03-09T10:20:34Z'
+git_revision: 346b0ef0ea81458a127d085461cc02d16349da17
+timestamp: '2022-03-16T07:37:00Z'
diff --git a/mpsl/lib/cortex-m4/hard-float/libmpsl.a b/mpsl/lib/cortex-m4/hard-float/libmpsl.a
index 8764509464..2c98677bea 100644
Binary files a/mpsl/lib/cortex-m4/hard-float/libmpsl.a and b/mpsl/lib/cortex-m4/hard-float/libmpsl.a differ
diff --git a/mpsl/lib/cortex-m4/hard-float/manifest.yaml b/mpsl/lib/cortex-m4/hard-float/manifest.yaml
index 46c3f8a9ba..d3cf6cc0dd 100644
--- a/mpsl/lib/cortex-m4/hard-float/manifest.yaml
+++ b/mpsl/lib/cortex-m4/hard-float/manifest.yaml
@@ -1,3 +1,3 @@
 description: Multi-Protocol Service Layer (MPSL)
-git_revision: 7ae19e799ec1b949d7614b906c21ead36f7fa18f
-timestamp: '2022-03-09T10:21:25Z'
+git_revision: 346b0ef0ea81458a127d085461cc02d16349da17
+timestamp: '2022-03-16T07:38:25Z'
diff --git a/mpsl/lib/cortex-m4/soft-float/libmpsl.a b/mpsl/lib/cortex-m4/soft-float/libmpsl.a
index eeb585a8d3..48dc34fa03 100644
Binary files a/mpsl/lib/cortex-m4/soft-float/libmpsl.a and b/mpsl/lib/cortex-m4/soft-float/libmpsl.a differ
diff --git a/mpsl/lib/cortex-m4/soft-float/manifest.yaml b/mpsl/lib/cortex-m4/soft-float/manifest.yaml
index 46c3f8a9ba..d3cf6cc0dd 100644
--- a/mpsl/lib/cortex-m4/soft-float/manifest.yaml
+++ b/mpsl/lib/cortex-m4/soft-float/manifest.yaml
@@ -1,3 +1,3 @@
 description: Multi-Protocol Service Layer (MPSL)
-git_revision: 7ae19e799ec1b949d7614b906c21ead36f7fa18f
-timestamp: '2022-03-09T10:21:25Z'
+git_revision: 346b0ef0ea81458a127d085461cc02d16349da17
+timestamp: '2022-03-16T07:38:25Z'
diff --git a/mpsl/lib/cortex-m4/softfp-float/libmpsl.a b/mpsl/lib/cortex-m4/softfp-float/libmpsl.a
index a3630bc8e4..2afbd091ed 100644
Binary files a/mpsl/lib/cortex-m4/softfp-float/libmpsl.a and b/mpsl/lib/cortex-m4/softfp-float/libmpsl.a differ
diff --git a/mpsl/lib/cortex-m4/softfp-float/manifest.yaml b/mpsl/lib/cortex-m4/softfp-float/manifest.yaml
index 46c3f8a9ba..d3cf6cc0dd 100644
--- a/mpsl/lib/cortex-m4/softfp-float/manifest.yaml
+++ b/mpsl/lib/cortex-m4/softfp-float/manifest.yaml
@@ -1,3 +1,3 @@
 description: Multi-Protocol Service Layer (MPSL)
-git_revision: 7ae19e799ec1b949d7614b906c21ead36f7fa18f
-timestamp: '2022-03-09T10:21:25Z'
+git_revision: 346b0ef0ea81458a127d085461cc02d16349da17
+timestamp: '2022-03-16T07:38:25Z'