diff --git a/openthread/CMakeLists.txt b/openthread/CMakeLists.txt
index c1e6acce43..838fe264e3 100644
--- a/openthread/CMakeLists.txt
+++ b/openthread/CMakeLists.txt
@@ -23,7 +23,7 @@ if(CONFIG_OPENTHREAD_SOURCES)
   set(OPENTHREAD_UTILS_DST_DIR "${NRFXLIB_DIR}/openthread/include/utils")
   set(OPENTHREAD_SYSTEM_H "${ZEPHYR_OPENTHREAD_MODULE_DIR}/examples/platforms/openthread-system.h")
   set(OPENTHREAD_UART_H "${ZEPHYR_OPENTHREAD_MODULE_DIR}/examples/platforms/utils/uart.h")
-  set(NRF_SECURITY_MBEDTLS_CONFIG_FILE ${CMAKE_CURRENT_BINARY_DIR}/../nrf_security/include/${CONFIG_MBEDTLS_CFG_FILE})
+  set(NRF_SECURITY_MBEDTLS_CONFIG_FILE ${CMAKE_CURRENT_BINARY_DIR}/../nrf_security/src/include/generated/${CONFIG_MBEDTLS_CFG_FILE})
 
   if(CONFIG_OPENTHREAD_BUILD_OUTPUT_STRIPPED)
     foreach(target IN LISTS OPENTHREAD_LIBRARIES)