diff --git a/bugsigdb_signatures_mixed_metaphlan.gmt b/bugsigdb_signatures_mixed_metaphlan.gmt
index 03cb462a5..e1549fa4e 100644
--- a/bugsigdb_signatures_mixed_metaphlan.gmt
+++ b/bugsigdb_signatures_mixed_metaphlan.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea	k__Bacteria|p__Bacillota|c__Negativicutes|o__Acidaminococcales|f__Acidaminococcaceae|g__Phascolarctobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Sutterellaceae|g__Sutterella	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Alcaligenaceae	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Enterobacterales	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae|g__Bacillus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	k__Bacteria|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Coprobacillaceae|g__Coprobacillus	k__Bacteria|p__Cyanobacteriota
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Anaerostipes	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
@@ -6321,7 +6321,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	k__Bacteria|k__Fusobacte
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus mitis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus vestibularis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus epidermidis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella amnii	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Arcanobacterium|s__Arcanobacterium sp.	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Winkia|s__Winkia neuii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinotignum|s__Actinotignum schaalii
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus hydrogenalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus lactolyticus	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus prevotii	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium amycolatum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium aurimucosum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium glucuronolyticum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium jeikeium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium pseudogenitalium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium striatum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Eremococcus|s__Eremococcus coleocola	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Finegoldia|s__Finegoldia magna	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus helveticus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Pseudoleptotrichia|s__Pseudoleptotrichia goodfellowii	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium|s__Oribacterium sp.	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus duerdenii	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus harei	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas|s__Porphyromonas somerae	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Propionimicrobium|s__Propionimicrobium lymphophilum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus dysgalactiae	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus equinus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus pseudoporcinus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia	k__Bacteria|k__Pseudomonadati|p__Spirochaetota|c__Spirochaetia|o__Spirochaetales|f__Treponemataceae|g__Treponema|s__Treponema phagedenis	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma parvum	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__Veillonella ratti
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium tuberculostearicum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__Mediterraneibacter faecis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__[Ruminococcus] torques	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Micrococcales|f__Microbacteriaceae|g__Microbacterium|s__Microbacterium lacus
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Hyphomicrobiales|f__Methylobacteriaceae|g__Methylorubrum|s__Methylorubrum extorquens	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Hyphomicrobiales|f__Methylobacteriaceae|g__Methylobacterium
diff --git a/bugsigdb_signatures_mixed_ncbi.gmt b/bugsigdb_signatures_mixed_ncbi.gmt
index 284fb0321..50490b917 100644
--- a/bugsigdb_signatures_mixed_ncbi.gmt
+++ b/bugsigdb_signatures_mixed_ncbi.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	91061	1236	1654	1716	1301	162289	189330	33024	40544	2037	2049	506	186826	1300	31977	91347	1653	57037	1386	186817
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	100883	1117
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	207244	57037
@@ -6321,7 +6321,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	861
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	2130	28112	28037	1343	1280	1282	28129	28136	419005	242750	59823	33031	2052	2051	157688	1632	147802	1596	1613	143361	178214	1351	39486	76517	216816	1685	72409	33036	1376	131111	33007	55565	66228	59505
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	1596
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	66228	55565	131111	1376	33029	33032	33034	33036	1685	216816	76517	43765	169292	39791	38289	38303	43770	39486	1352	1351	178214	143361	88132	1260	1613	1596	1587	1632	147802	157692	157688	1969407	2051	2052	507750	54005	33031	322095	242750	28136	28129	59823	33012	1280	1334	1335	361101	28112	162	2130	134821	103892
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	2721132	186801	291645	1694	78448
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	291645	1694	78448	2721132	186801
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	2721132
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	38304	178214	592978	33039	1716	66831
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	201174	415217
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	408	407
diff --git a/bugsigdb_signatures_mixed_taxname.gmt b/bugsigdb_signatures_mixed_taxname.gmt
index fa824c01b..f4e18b06e 100644
--- a/bugsigdb_signatures_mixed_taxname.gmt
+++ b/bugsigdb_signatures_mixed_taxname.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	Bacilli	Gammaproteobacteria	Actinomyces	Corynebacterium	Streptococcus	Peptoniphilus	Dorea	Phascolarctobacterium	Sutterella	Actinomycetales	Actinomycetaceae	Alcaligenaceae	Lactobacillales	Streptococcaceae	Veillonellaceae	Enterobacterales	Corynebacteriaceae	Lacticaseibacillus zeae	Bacillus	Bacillaceae
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	Coprobacillus	Cyanobacteriota
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	Anaerostipes	Lacticaseibacillus zeae
@@ -6321,7 +6321,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	Fusobacterium ulcerans
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	Ureaplasma urealyticum	Tannerella forsythia	Streptococcus mitis	Streptococcus vestibularis	Staphylococcus aureus	Staphylococcus epidermidis	Prevotella denticola	Segatella oulorum	Prevotella amnii	Hallella bergensis	Prevotella sp.	Peptoniphilus lacrimalis	Mobiluncus mulieris	Mobiluncus curtisii	Leptotrichia hofstadii	Limosilactobacillus oris	Lactobacillus iners	Lactobacillus gasseri	Limosilactobacillus fermentum	Filifactor alocis	Facklamia hominis	Enterococcus faecalis	Dorea formicigenerans	Campylobacter hominis	Bifidobacterium longum	Bifidobacterium breve	Arcanobacterium sp.	Anaerococcus tetradius	Aerococcus urinae	Schaalia turicensis	Winkia neuii	Actinomyces graevenitzii	Gleimia europaea	Actinotignum schaalii
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	Lactobacillus gasseri
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	Gleimia europaea	Actinomyces graevenitzii	Schaalia turicensis	Aerococcus urinae	Anaerococcus hydrogenalis	Anaerococcus lactolyticus	Anaerococcus prevotii	Anaerococcus tetradius	Bifidobacterium breve	Bifidobacterium longum	Campylobacter hominis	Corynebacterium amycolatum	Corynebacterium aurimucosum	Corynebacterium glucuronolyticum	Corynebacterium jeikeium	Corynebacterium pseudogenitalium	Corynebacterium striatum	Dorea formicigenerans	Enterococcus faecium	Enterococcus faecalis	Facklamia hominis	Filifactor alocis	Eremococcus coleocola	Finegoldia magna	Limosilactobacillus fermentum	Lactobacillus gasseri	Lactobacillus helveticus	Limosilactobacillus oris	Lactobacillus iners	Pseudoleptotrichia goodfellowii	Leptotrichia hofstadii	Oribacterium sp.	Mobiluncus curtisii	Mobiluncus mulieris	Peptoniphilus duerdenii	Peptoniphilus harei	Peptoniphilus lacrimalis	Porphyromonas somerae	Hallella bergensis	Segatella oulorum	Prevotella denticola	Prevotella sp.	Propionimicrobium lymphophilum	Staphylococcus aureus	Streptococcus dysgalactiae	Streptococcus equinus	Streptococcus pseudoporcinus	Tannerella forsythia	Treponema phagedenis	Ureaplasma urealyticum	Ureaplasma parvum	Veillonella ratti
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Candidatus Metalachnospira gallinarum	Clostridia	Bacteroides nordii	Bifidobacterium pseudolongum	Bifidobacterium pullorum
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Bacteroides nordii	Bifidobacterium pseudolongum	Bifidobacterium pullorum	Candidatus Metalachnospira gallinarum	Clostridia
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Candidatus Metalachnospira gallinarum
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	Corynebacterium tuberculostearicum	Facklamia hominis	Mediterraneibacter faecis	[Ruminococcus] torques	Corynebacterium	Facklamia
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	Actinomycetota	Microbacterium lacus
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	Methylorubrum extorquens	Methylobacterium
diff --git a/bugsigdb_signatures_species_metaphlan.gmt b/bugsigdb_signatures_species_metaphlan.gmt
index 9cb1f56b8..1e580352b 100644
--- a/bugsigdb_signatures_species_metaphlan.gmt
+++ b/bugsigdb_signatures_species_metaphlan.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
 bsdb:1/6/1_Colorectal-adenoma:Non-advanced-conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
@@ -2757,7 +2757,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	k__Bacteria|k__Fusobacte
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus mitis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus vestibularis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus epidermidis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella amnii	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Arcanobacterium|s__Arcanobacterium sp.	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Winkia|s__Winkia neuii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinotignum|s__Actinotignum schaalii
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus hydrogenalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus lactolyticus	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus prevotii	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium amycolatum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium aurimucosum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium glucuronolyticum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium jeikeium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium pseudogenitalium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium striatum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Eremococcus|s__Eremococcus coleocola	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Finegoldia|s__Finegoldia magna	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus helveticus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Pseudoleptotrichia|s__Pseudoleptotrichia goodfellowii	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium|s__Oribacterium sp.	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus duerdenii	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus harei	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas|s__Porphyromonas somerae	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Propionimicrobium|s__Propionimicrobium lymphophilum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus dysgalactiae	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus equinus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus pseudoporcinus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia	k__Bacteria|k__Pseudomonadati|p__Spirochaetota|c__Spirochaetia|o__Spirochaetales|f__Treponemataceae|g__Treponema|s__Treponema phagedenis	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma parvum	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__Veillonella ratti
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium tuberculostearicum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__Mediterraneibacter faecis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__[Ruminococcus] torques
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Micrococcales|f__Microbacteriaceae|g__Microbacterium|s__Microbacterium lacus
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Hyphomicrobiales|f__Methylobacteriaceae|g__Methylorubrum|s__Methylorubrum extorquens
diff --git a/bugsigdb_signatures_species_metaphlan_exact.gmt b/bugsigdb_signatures_species_metaphlan_exact.gmt
index 9cb1f56b8..1e580352b 100644
--- a/bugsigdb_signatures_species_metaphlan_exact.gmt
+++ b/bugsigdb_signatures_species_metaphlan_exact.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
 bsdb:1/6/1_Colorectal-adenoma:Non-advanced-conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
@@ -2757,7 +2757,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	k__Bacteria|k__Fusobacte
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus mitis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus vestibularis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus epidermidis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella amnii	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Arcanobacterium|s__Arcanobacterium sp.	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Winkia|s__Winkia neuii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinotignum|s__Actinotignum schaalii
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus hydrogenalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus lactolyticus	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus prevotii	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium amycolatum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium aurimucosum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium glucuronolyticum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium jeikeium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium pseudogenitalium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium striatum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Eremococcus|s__Eremococcus coleocola	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Finegoldia|s__Finegoldia magna	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus helveticus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Pseudoleptotrichia|s__Pseudoleptotrichia goodfellowii	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium|s__Oribacterium sp.	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus duerdenii	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus harei	k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas|s__Porphyromonas somerae	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Propionimicrobium|s__Propionimicrobium lymphophilum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus dysgalactiae	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus equinus	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus pseudoporcinus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia	k__Bacteria|k__Pseudomonadati|p__Spirochaetota|c__Spirochaetia|o__Spirochaetales|f__Treponemataceae|g__Treponema|s__Treponema phagedenis	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum	k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma parvum	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__Veillonella ratti
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium tuberculostearicum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__Mediterraneibacter faecis	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__[Ruminococcus] torques
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Micrococcales|f__Microbacteriaceae|g__Microbacterium|s__Microbacterium lacus
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Hyphomicrobiales|f__Methylobacteriaceae|g__Methylorubrum|s__Methylorubrum extorquens
diff --git a/bugsigdb_signatures_species_ncbi.gmt b/bugsigdb_signatures_species_ncbi.gmt
index 37c4a5ffb..96d89d9e5 100644
--- a/bugsigdb_signatures_species_ncbi.gmt
+++ b/bugsigdb_signatures_species_ncbi.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	57037
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	57037
 bsdb:1/6/1_Colorectal-adenoma:Non-advanced-conventional-adenoma-cases_vs_controls_UP	NA	57037
@@ -2757,7 +2757,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	861
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	2130	28112	28037	1343	1280	1282	28129	28136	419005	242750	59823	33031	2052	2051	157688	1632	147802	1596	1613	143361	178214	1351	39486	76517	216816	1685	72409	33036	1376	131111	33007	55565	66228	59505
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	1596
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	66228	55565	131111	1376	33029	33032	33034	33036	1685	216816	76517	43765	169292	39791	38289	38303	43770	39486	1352	1351	178214	143361	88132	1260	1613	1596	1587	1632	147802	157692	157688	1969407	2051	2052	507750	54005	33031	322095	242750	28136	28129	59823	33012	1280	1334	1335	361101	28112	162	2130	134821	103892
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	2721132	291645	1694	78448
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	291645	1694	78448	2721132
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	2721132
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	38304	178214	592978	33039
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	415217
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	408
diff --git a/bugsigdb_signatures_species_ncbi_exact.gmt b/bugsigdb_signatures_species_ncbi_exact.gmt
index 37c4a5ffb..96d89d9e5 100644
--- a/bugsigdb_signatures_species_ncbi_exact.gmt
+++ b/bugsigdb_signatures_species_ncbi_exact.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	57037
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	57037
 bsdb:1/6/1_Colorectal-adenoma:Non-advanced-conventional-adenoma-cases_vs_controls_UP	NA	57037
@@ -2757,7 +2757,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	861
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	2130	28112	28037	1343	1280	1282	28129	28136	419005	242750	59823	33031	2052	2051	157688	1632	147802	1596	1613	143361	178214	1351	39486	76517	216816	1685	72409	33036	1376	131111	33007	55565	66228	59505
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	1596
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	66228	55565	131111	1376	33029	33032	33034	33036	1685	216816	76517	43765	169292	39791	38289	38303	43770	39486	1352	1351	178214	143361	88132	1260	1613	1596	1587	1632	147802	157692	157688	1969407	2051	2052	507750	54005	33031	322095	242750	28136	28129	59823	33012	1280	1334	1335	361101	28112	162	2130	134821	103892
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	2721132	291645	1694	78448
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	291645	1694	78448	2721132
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	2721132
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	38304	178214	592978	33039
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	415217
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	408
diff --git a/bugsigdb_signatures_species_taxname.gmt b/bugsigdb_signatures_species_taxname.gmt
index 7c93518e0..60dcc5aea 100644
--- a/bugsigdb_signatures_species_taxname.gmt
+++ b/bugsigdb_signatures_species_taxname.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	Lacticaseibacillus zeae
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	Lacticaseibacillus zeae
 bsdb:1/6/1_Colorectal-adenoma:Non-advanced-conventional-adenoma-cases_vs_controls_UP	NA	Lacticaseibacillus zeae
@@ -2757,7 +2757,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	Fusobacterium ulcerans
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	Ureaplasma urealyticum	Tannerella forsythia	Streptococcus mitis	Streptococcus vestibularis	Staphylococcus aureus	Staphylococcus epidermidis	Prevotella denticola	Segatella oulorum	Prevotella amnii	Hallella bergensis	Prevotella sp.	Peptoniphilus lacrimalis	Mobiluncus mulieris	Mobiluncus curtisii	Leptotrichia hofstadii	Limosilactobacillus oris	Lactobacillus iners	Lactobacillus gasseri	Limosilactobacillus fermentum	Filifactor alocis	Facklamia hominis	Enterococcus faecalis	Dorea formicigenerans	Campylobacter hominis	Bifidobacterium longum	Bifidobacterium breve	Arcanobacterium sp.	Anaerococcus tetradius	Aerococcus urinae	Schaalia turicensis	Winkia neuii	Actinomyces graevenitzii	Gleimia europaea	Actinotignum schaalii
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	Lactobacillus gasseri
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	Gleimia europaea	Actinomyces graevenitzii	Schaalia turicensis	Aerococcus urinae	Anaerococcus hydrogenalis	Anaerococcus lactolyticus	Anaerococcus prevotii	Anaerococcus tetradius	Bifidobacterium breve	Bifidobacterium longum	Campylobacter hominis	Corynebacterium amycolatum	Corynebacterium aurimucosum	Corynebacterium glucuronolyticum	Corynebacterium jeikeium	Corynebacterium pseudogenitalium	Corynebacterium striatum	Dorea formicigenerans	Enterococcus faecium	Enterococcus faecalis	Facklamia hominis	Filifactor alocis	Eremococcus coleocola	Finegoldia magna	Limosilactobacillus fermentum	Lactobacillus gasseri	Lactobacillus helveticus	Limosilactobacillus oris	Lactobacillus iners	Pseudoleptotrichia goodfellowii	Leptotrichia hofstadii	Oribacterium sp.	Mobiluncus curtisii	Mobiluncus mulieris	Peptoniphilus duerdenii	Peptoniphilus harei	Peptoniphilus lacrimalis	Porphyromonas somerae	Hallella bergensis	Segatella oulorum	Prevotella denticola	Prevotella sp.	Propionimicrobium lymphophilum	Staphylococcus aureus	Streptococcus dysgalactiae	Streptococcus equinus	Streptococcus pseudoporcinus	Tannerella forsythia	Treponema phagedenis	Ureaplasma urealyticum	Ureaplasma parvum	Veillonella ratti
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Candidatus Metalachnospira gallinarum	Bacteroides nordii	Bifidobacterium pseudolongum	Bifidobacterium pullorum
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Bacteroides nordii	Bifidobacterium pseudolongum	Bifidobacterium pullorum	Candidatus Metalachnospira gallinarum
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Candidatus Metalachnospira gallinarum
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	Corynebacterium tuberculostearicum	Facklamia hominis	Mediterraneibacter faecis	[Ruminococcus] torques
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	Microbacterium lacus
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	Methylorubrum extorquens
diff --git a/bugsigdb_signatures_species_taxname_exact.gmt b/bugsigdb_signatures_species_taxname_exact.gmt
index 7c93518e0..60dcc5aea 100644
--- a/bugsigdb_signatures_species_taxname_exact.gmt
+++ b/bugsigdb_signatures_species_taxname_exact.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	Lacticaseibacillus zeae
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	Lacticaseibacillus zeae
 bsdb:1/6/1_Colorectal-adenoma:Non-advanced-conventional-adenoma-cases_vs_controls_UP	NA	Lacticaseibacillus zeae
@@ -2757,7 +2757,8 @@ bsdb:1229/5/1_Endometrial-cancer:Serous_vs_Benign_UP	NA	Fusobacterium ulcerans
 bsdb:1229/5/2_Endometrial-cancer:Serous_vs_Benign_DOWN	NA	Ureaplasma urealyticum	Tannerella forsythia	Streptococcus mitis	Streptococcus vestibularis	Staphylococcus aureus	Staphylococcus epidermidis	Prevotella denticola	Segatella oulorum	Prevotella amnii	Hallella bergensis	Prevotella sp.	Peptoniphilus lacrimalis	Mobiluncus mulieris	Mobiluncus curtisii	Leptotrichia hofstadii	Limosilactobacillus oris	Lactobacillus iners	Lactobacillus gasseri	Limosilactobacillus fermentum	Filifactor alocis	Facklamia hominis	Enterococcus faecalis	Dorea formicigenerans	Campylobacter hominis	Bifidobacterium longum	Bifidobacterium breve	Arcanobacterium sp.	Anaerococcus tetradius	Aerococcus urinae	Schaalia turicensis	Winkia neuii	Actinomyces graevenitzii	Gleimia europaea	Actinotignum schaalii
 bsdb:1229/6/1_Endometrial-cancer:Endometroid_vs_Benign_UP	NA	Lactobacillus gasseri
 bsdb:1229/7/1_Endometrial-cancer:Serous_vs_Endometroid_DOWN	NA	Gleimia europaea	Actinomyces graevenitzii	Schaalia turicensis	Aerococcus urinae	Anaerococcus hydrogenalis	Anaerococcus lactolyticus	Anaerococcus prevotii	Anaerococcus tetradius	Bifidobacterium breve	Bifidobacterium longum	Campylobacter hominis	Corynebacterium amycolatum	Corynebacterium aurimucosum	Corynebacterium glucuronolyticum	Corynebacterium jeikeium	Corynebacterium pseudogenitalium	Corynebacterium striatum	Dorea formicigenerans	Enterococcus faecium	Enterococcus faecalis	Facklamia hominis	Filifactor alocis	Eremococcus coleocola	Finegoldia magna	Limosilactobacillus fermentum	Lactobacillus gasseri	Lactobacillus helveticus	Limosilactobacillus oris	Lactobacillus iners	Pseudoleptotrichia goodfellowii	Leptotrichia hofstadii	Oribacterium sp.	Mobiluncus curtisii	Mobiluncus mulieris	Peptoniphilus duerdenii	Peptoniphilus harei	Peptoniphilus lacrimalis	Porphyromonas somerae	Hallella bergensis	Segatella oulorum	Prevotella denticola	Prevotella sp.	Propionimicrobium lymphophilum	Staphylococcus aureus	Streptococcus dysgalactiae	Streptococcus equinus	Streptococcus pseudoporcinus	Tannerella forsythia	Treponema phagedenis	Ureaplasma urealyticum	Ureaplasma parvum	Veillonella ratti
-bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Candidatus Metalachnospira gallinarum	Bacteroides nordii	Bifidobacterium pseudolongum	Bifidobacterium pullorum
+bsdb:1230/1/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Bacteroides nordii	Bifidobacterium pseudolongum	Bifidobacterium pullorum	Candidatus Metalachnospira gallinarum
+bsdb:1230/2/1_Melanoma:complete-responders-(CR)_vs_non-complete-responders-(nCR)_UP	NA	Candidatus Metalachnospira gallinarum
 bsdb:1231/1/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	Corynebacterium tuberculostearicum	Facklamia hominis	Mediterraneibacter faecis	[Ruminococcus] torques
 bsdb:1231/2/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_DOWN	NA	Microbacterium lacus
 bsdb:1231/3/1_Ovarian-cancer:Ovarian-cancer_vs_Benign_UP	NA	Methylorubrum extorquens
diff --git a/file_size.csv b/file_size.csv
index 4e2a0d01e..333f2caa3 100644
--- a/file_size.csv
+++ b/file_size.csv
@@ -2791,3 +2791,4 @@
 "2025-01-25_06:58_UTC" "4916" "5687" "4916" "5687" "4916" "5687" "6739" "6739" "6739" "3020" "3020" "3020" "3020" "3020" "3020" "4543" "7832" "7424" "1384"
 "2025-01-25_07:58_UTC" "4916" "5687" "4916" "5687" "4916" "5687" "6739" "6739" "6739" "3020" "3020" "3020" "3020" "3020" "3020" "4543" "7832" "7424" "1384"
 "2025-01-25_08:58_UTC" "4916" "5687" "4916" "5687" "4916" "5687" "6739" "6739" "6739" "3020" "3020" "3020" "3020" "3020" "3020" "4543" "7832" "7424" "1384"
+"2025-01-25_09:58_UTC" "4916" "5687" "4916" "5687" "4916" "5687" "6740" "6740" "6740" "3021" "3021" "3021" "3021" "3021" "3021" "4543" "7832" "7424" "1384"
diff --git a/full_dump.csv b/full_dump.csv
index a47897a92..759ecacd6 100644
--- a/full_dump.csv
+++ b/full_dump.csv
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-24_21:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-25_09:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 BSDB ID,Study,Study design,PMID,DOI,URL,Authors list,Title,Journal,Year,Keywords,Experiment,Location of subjects,Host species,Body site,UBERON ID,Condition,EFO ID,Group 0 name,Group 1 name,Group 1 definition,Group 0 sample size,Group 1 sample size,Antibiotics exclusion,Sequencing type,16S variable region,Sequencing platform,Statistical test,Significance threshold,MHT correction,LDA Score above,Matched on,Confounders controlled for,Pielou,Shannon,Chao1,Simpson,Inverse Simpson,Richness,Signature page name,Source,Curated date,Curator,Revision editor,Description,Abundance in Group 1,MetaPhlAn taxon names,NCBI Taxonomy IDs,State,Reviewer
 bsdb:1/1/1,Study 1,case-control,28038683,10.1186/s40168-016-0218-6,NA,"Peters BA, Dominianni C, Shapiro JA, Church TR, Wu J, Miller G, Yuen E, Freiman H, Lustbader I, Salik J, Friedlander C, Hayes RB , Ahn J",The gut microbiota in conventional and serrated precursors of colorectal cancer,Microbiome,2016,"Adenoma, Cancer, Colorectal, Microbiome, Microbiota, Polyp, Serrated",Experiment 1,United States of America,Homo sapiens,Feces,UBERON:0001988,Colorectal adenoma,EFO:0005406,controls,conventional adenoma cases,"conventional adenoma cases; those with at least one tubular or tubulovillous adenoma and no other polyps of hyperplastic, SSA, or unclassified histology. HP cases; having at least one HP, with no other polyps of tubular, tubulovillous, SSA, or unclassified histology. SSA cases; having at least one SSA, with or without HP(s), and with no other polyps of tubular, tubulovillous, or unclassified histology. Proximal polyps; polyps located in the cecum, ascending colon, hepatic flexure, transverse colon, or splenic flexure. Distal polyps; polyps located in the descending colon, sigmoid colon, or rectum.",323,144,NYU included who had not been on long-term antibiotic treatment,16S,4,Illumina,DESeq2,0.1,TRUE,NA,NA,"age,body mass index,sex",NA,decreased,NA,NA,NA,decreased,Signature 1,Table 2 + Supplemental Table S5 + S3+ S4,10 January 2021,Levi Waldron,WikiWorks,"Differential abundance was detected by the “DESeq” function in the DESeq2 package. All classes and genera with an FDR-adjusted q < 0.10 are included in the table. Models were adjusted for sex, age, study, and categorical BMI. See Additional file 1: Table S5 for comparisons at the phylum, order, and family level",increased,"k__Bacteria|p__Bacillota|c__Bacilli,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea,k__Bacteria|p__Bacillota|c__Negativicutes|o__Acidaminococcales|f__Acidaminococcaceae|g__Phascolarctobacterium,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Sutterellaceae|g__Sutterella,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Alcaligenaceae,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae,k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Enterobacterales,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae|g__Bacillus,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae",2|1239|91061;2|1224|1236;2|201174|1760|2037|2049|1654;2|201174|1760|85007|1653|1716;2|1239|91061|186826|1300|1301;2|1239|1737404|1737405|1570339|162289;2|1239|186801|3085636|186803|189330;2|1239|909932|1843488|909930|33024;2|1224|28216|80840|995019|40544;2|201174|1760|2037;2|201174|1760|2037|2049;2|1224|28216|80840|506;2|1239|91061|186826;2|1239|91061|186826|1300;2|1239|909932|1843489|31977;2|1224|1236|91347;2|201174|1760|85007|1653;2|1239|91061|186826|33958|2759736|57037;2|1239|91061|1385|186817|1386;2|1239|91061|1385|186817,Complete,Fatima
 bsdb:1/1/2,Study 1,case-control,28038683,10.1186/s40168-016-0218-6,NA,"Peters BA, Dominianni C, Shapiro JA, Church TR, Wu J, Miller G, Yuen E, Freiman H, Lustbader I, Salik J, Friedlander C, Hayes RB , Ahn J",The gut microbiota in conventional and serrated precursors of colorectal cancer,Microbiome,2016,"Adenoma, Cancer, Colorectal, Microbiome, Microbiota, Polyp, Serrated",Experiment 1,United States of America,Homo sapiens,Feces,UBERON:0001988,Colorectal adenoma,EFO:0005406,controls,conventional adenoma cases,"conventional adenoma cases; those with at least one tubular or tubulovillous adenoma and no other polyps of hyperplastic, SSA, or unclassified histology. HP cases; having at least one HP, with no other polyps of tubular, tubulovillous, SSA, or unclassified histology. SSA cases; having at least one SSA, with or without HP(s), and with no other polyps of tubular, tubulovillous, or unclassified histology. Proximal polyps; polyps located in the cecum, ascending colon, hepatic flexure, transverse colon, or splenic flexure. Distal polyps; polyps located in the descending colon, sigmoid colon, or rectum.",323,144,NYU included who had not been on long-term antibiotic treatment,16S,4,Illumina,DESeq2,0.1,TRUE,NA,NA,"age,body mass index,sex",NA,decreased,NA,NA,NA,decreased,Signature 2,Table 2 + Supplemental Table S5 + S3+ S4,10 January 2021,Levi Waldron,WikiWorks,"Differential abundance was detected by the “DESeq” function in the DESeq2 package. All classes and genera with an FDR-adjusted q < 0.10 are included in the table. Models were adjusted for sex, age, study, and categorical BMI. See Additional file 1: Table S5 for comparisons at the phylum, order, and family level",decreased,"k__Bacteria|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Coprobacillaceae|g__Coprobacillus,k__Bacteria|p__Cyanobacteriota",2|1239|526524|526525|2810280|100883;2|1117,Complete,Shaimaa Elsafoury
@@ -7388,8 +7388,8 @@ bsdb:1229/5/1,Study 1229,"cross-sectional observational, not case-control",35928
 bsdb:1229/5/2,Study 1229,"cross-sectional observational, not case-control",35928983,https://doi.org/10.1158/2767-9764.CRC-22-0075,NA,"Hakimjavadi H, George SH, Taub M, Dodds LV, Sanchez-Covarrubias AP, Huang M, Pearson JM, Slomovitz BM, Kobetz EN, Gharaibeh R, Sowamber R, Pinto A, Chamala S , Schlumbrecht MP",The vaginal microbiome is associated with endometrial cancer grade and histology,Cancer research communications,2022,"Endometrial cancer, high-grade, low-grade, metagenomics, microbiome",Experiment 5,United States of America,Homo sapiens,Vagina,UBERON:0000996,Endometrial cancer,MONDO:0011962,Benign,Serous,"Serous histology is a term used to describe the histology of tumors, carcinomas, and other tissues that are associated with serum, the clear liquid part of blood.",11,NA,14 days,WMS,NA,BGISEQ-500 Sequencing,DESeq2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 2,Supplementary Figure 5A,26 December 2024,KateRasheed,KateRasheed,Differential abundance of taxa between Benign and Serous,decreased,"k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus mitis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus vestibularis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus epidermidis,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella amnii,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans,k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Arcanobacterium|s__Arcanobacterium sp.,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Winkia|s__Winkia neuii,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinotignum|s__Actinotignum schaalii",2|1783272|544448|2790996|2790998|2129|2130;2|3379134|976|200643|171549|2005525|195950|28112;2|1783272|1239|91061|186826|1300|1301|28037;2|1783272|1239|91061|186826|1300|1301|1343;2|1783272|1239|91061|1385|90964|1279|1280;2|1783272|1239|91061|1385|90964|1279|1282;2|3379134|976|200643|171549|171552|838|28129;2|3379134|976|200643|171549|171552|2974251|28136;2|3379134|976|200643|171549|171552|838|419005;2|3379134|976|200643|171549|171552|52228|242750;2|3379134|976|200643|171549|171552|838|59823;2|1783272|1239|1737404|1737405|1570339|162289|33031;2|1783272|201174|1760|2037|2049|2050|2052;2|1783272|201174|1760|2037|2049|2050|2051;2|3384189|32066|203490|203491|1129771|32067|157688;2|1783272|1239|91061|186826|33958|2742598|1632;2|1783272|1239|91061|186826|33958|1578|147802;2|1783272|1239|91061|186826|33958|1578|1596;2|1783272|1239|91061|186826|33958|2742598|1613;2|1783272|1239|186801|3082720|3118655|44259|143361;2|1783272|1239|91061|186826|186827|66831|178214;2|1783272|1239|91061|186826|81852|1350|1351;2|1783272|1239|186801|3085636|186803|189330|39486;2|3379134|29547|3031852|213849|72294|194|76517;2|1783272|201174|1760|85004|31953|1678|216816;2|1783272|201174|1760|85004|31953|1678|1685;2|1783272|201174|1760|2037|2049|28263|72409;2|1783272|1239|1737404|1737405|1570339|165779|33036;2|1783272|1239|91061|186826|186827|1375|1376;2|1783272|201174|1760|2037|2049|2529408|131111;2|1783272|201174|1760|2037|2049|2692118|33007;2|1783272|201174|1760|2037|2049|1654|55565;2|1783272|201174|1760|2037|2049|2692113|66228;2|1783272|201174|1760|2037|2049|1653174|59505,Complete,Svetlana up
 bsdb:1229/6/1,Study 1229,"cross-sectional observational, not case-control",35928983,https://doi.org/10.1158/2767-9764.CRC-22-0075,NA,"Hakimjavadi H, George SH, Taub M, Dodds LV, Sanchez-Covarrubias AP, Huang M, Pearson JM, Slomovitz BM, Kobetz EN, Gharaibeh R, Sowamber R, Pinto A, Chamala S , Schlumbrecht MP",The vaginal microbiome is associated with endometrial cancer grade and histology,Cancer research communications,2022,"Endometrial cancer, high-grade, low-grade, metagenomics, microbiome",Experiment 6,United States of America,Homo sapiens,Vagina,UBERON:0000996,Endometrial cancer,MONDO:0011962,Benign,Endometroid,Endometrioid histology is a type of endometrial carcinoma that is the most common histological type of uterine body cancer.,11,NA,14 days,WMS,NA,BGISEQ-500 Sequencing,DESeq2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 1,Supplementary Figure 5B,26 December 2024,KateRasheed,KateRasheed,Differential abundance of taxa between Benign and Endometroid,increased,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri,2|1783272|1239|91061|186826|33958|1578|1596,Complete,Svetlana up
 bsdb:1229/7/1,Study 1229,"cross-sectional observational, not case-control",35928983,https://doi.org/10.1158/2767-9764.CRC-22-0075,NA,"Hakimjavadi H, George SH, Taub M, Dodds LV, Sanchez-Covarrubias AP, Huang M, Pearson JM, Slomovitz BM, Kobetz EN, Gharaibeh R, Sowamber R, Pinto A, Chamala S , Schlumbrecht MP",The vaginal microbiome is associated with endometrial cancer grade and histology,Cancer research communications,2022,"Endometrial cancer, high-grade, low-grade, metagenomics, microbiome",Experiment 7,United States of America,Homo sapiens,Vagina,UBERON:0000996,Endometrial cancer,MONDO:0011962,Endometroid,Serous,"Serous histology is a term used to describe the histology of tumors, carcinomas, and other tissues that are associated with serum, the clear liquid part of blood.",NA,NA,14 days,WMS,NA,BGISEQ-500 Sequencing,DESeq2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 1,Supplementary Figure 5C,26 December 2024,KateRasheed,KateRasheed,Differential abundance of taxa between Endometroid and Serous,decreased,"k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Gleimia|s__Gleimia europaea,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces|s__Actinomyces graevenitzii,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Schaalia|s__Schaalia turicensis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus|s__Aerococcus urinae,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus hydrogenalis,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus lactolyticus,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus prevotii,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Anaerococcus|s__Anaerococcus tetradius,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium breve,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium longum,k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter|s__Campylobacter hominis,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium amycolatum,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium aurimucosum,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium glucuronolyticum,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium jeikeium,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium pseudogenitalium,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium striatum,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea|s__Dorea formicigenerans,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecium,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus|s__Enterococcus faecalis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Filifactoraceae|g__Filifactor|s__Filifactor alocis,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Eremococcus|s__Eremococcus coleocola,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Finegoldia|s__Finegoldia magna,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus fermentum,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus gasseri,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus helveticus,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Limosilactobacillus|s__Limosilactobacillus oris,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus|s__Lactobacillus iners,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Pseudoleptotrichia|s__Pseudoleptotrichia goodfellowii,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__Leptotrichia hofstadii,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium|s__Oribacterium sp.,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus curtisii,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Mobiluncus|s__Mobiluncus mulieris,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus duerdenii,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus harei,k__Bacteria|k__Bacillati|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus|s__Peptoniphilus lacrimalis,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas|s__Porphyromonas somerae,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Hallella|s__Hallella bergensis,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Segatella|s__Segatella oulorum,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella denticola,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella|s__Prevotella sp.,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Propionimicrobium|s__Propionimicrobium lymphophilum,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Staphylococcaceae|g__Staphylococcus|s__Staphylococcus aureus,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus dysgalactiae,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus equinus,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus pseudoporcinus,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella forsythia,k__Bacteria|k__Pseudomonadati|p__Spirochaetota|c__Spirochaetia|o__Spirochaetales|f__Treponemataceae|g__Treponema|s__Treponema phagedenis,k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma urealyticum,k__Bacteria|k__Bacillati|p__Mycoplasmatota|o__Mycoplasmoidales|f__Mycoplasmoidaceae|g__Ureaplasma|s__Ureaplasma parvum,k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__Veillonella ratti",2|1783272|201174|1760|2037|2049|2692113|66228;2|1783272|201174|1760|2037|2049|1654|55565;2|1783272|201174|1760|2037|2049|2529408|131111;2|1783272|1239|91061|186826|186827|1375|1376;2|1783272|1239|1737404|1737405|1570339|165779|33029;2|1783272|1239|1737404|1737405|1570339|165779|33032;2|1783272|1239|1737404|1737405|1570339|165779|33034;2|1783272|1239|1737404|1737405|1570339|165779|33036;2|1783272|201174|1760|85004|31953|1678|1685;2|1783272|201174|1760|85004|31953|1678|216816;2|3379134|29547|3031852|213849|72294|194|76517;2|1783272|201174|1760|85007|1653|1716|43765;2|1783272|201174|1760|85007|1653|1716|169292;2|1783272|201174|1760|85007|1653|1716|39791;2|1783272|201174|1760|85007|1653|1716|38289;2|1783272|201174|1760|85007|1653|1716|38303;2|1783272|201174|1760|85007|1653|1716|43770;2|1783272|1239|186801|3085636|186803|189330|39486;2|1783272|1239|91061|186826|81852|1350|1352;2|1783272|1239|91061|186826|81852|1350|1351;2|1783272|1239|91061|186826|186827|66831|178214;2|1783272|1239|186801|3082720|3118655|44259|143361;2|1783272|1239|91061|186826|186827|171412|88132;2|1783272|1239|1737404|1737405|1570339|150022|1260;2|1783272|1239|91061|186826|33958|2742598|1613;2|1783272|1239|91061|186826|33958|1578|1596;2|1783272|1239|91061|186826|33958|1578|1587;2|1783272|1239|91061|186826|33958|2742598|1632;2|1783272|1239|91061|186826|33958|1578|147802;2|3384189|32066|203490|203491|1129771|2755140|157692;2|3384189|32066|203490|203491|1129771|32067|157688;2|1783272|1239|186801|3085636|186803|265975|1969407;2|1783272|201174|1760|2037|2049|2050|2051;2|1783272|201174|1760|2037|2049|2050|2052;2|1783272|1239|1737404|1737405|1570339|162289|507750;2|1783272|1239|1737404|1737405|1570339|162289|54005;2|1783272|1239|1737404|1737405|1570339|162289|33031;2|3379134|976|200643|171549|171551|836|322095;2|3379134|976|200643|171549|171552|52228|242750;2|3379134|976|200643|171549|171552|2974251|28136;2|3379134|976|200643|171549|171552|838|28129;2|3379134|976|200643|171549|171552|838|59823;2|1783272|201174|1760|85009|31957|203133|33012;2|1783272|1239|91061|1385|90964|1279|1280;2|1783272|1239|91061|186826|1300|1301|1334;2|1783272|1239|91061|186826|1300|1301|1335;2|1783272|1239|91061|186826|1300|1301|361101;2|3379134|976|200643|171549|2005525|195950|28112;2|3379134|203691|203692|136|2845253|157|162;2|1783272|544448|2790996|2790998|2129|2130;2|1783272|544448|2790996|2790998|2129|134821;2|1783272|1239|909932|1843489|31977|29465|103892,Complete,Svetlana up
-bsdb:1230/1/1,Study 1230,time series / longitudinal observational,39481388,10.1016/j.chom.2024.10.006,NA,"Macandog ADG, Catozzi C, Capone M, Nabinejad A, Nanaware PP, Liu S, Vinjamuri S, Stunnenberg JA, Galiè S, Jodice MG, Montani F, Armanini F, Cassano E, Madonna G, Mallardo D, Mazzi B, Pece S, Tagliamonte M, Vanella V, Barberis M, Ferrucci PF, Blank CU, Bouvier M, Andrews MC, Xu X, Santambrogio L, Segata N, Buonaguro L, Cocorocchio E, Ascierto PA, Manzo T , Nezi L",Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients,Cell host & microbe,2024,"antigen mimicry, gut microbiome, immunotherapy, longitudinal, melanoma",Experiment 1,Italy,Homo sapiens,Feces,UBERON:0001988,Melanoma,EFO:0000756,non-complete responders (nCR),complete responders (CR),This group represents the Complete Responders (CR) to anti-PD-1 therapy in melanoma patients for 2-6 months (early therapy) .,14,23,30 days,16S,34,Illumina,MaAsLin2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 1,Figure S2D,19 November 2024,Joiejoie,Joiejoie,"This figure highlights the microbial taxa dynamics associated with treatment response, emphasizing the potential role of specific gut microbiota in influencing clinical outcomes during anti-PD-1 therapy.",increased,"k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum",2|1783272|1239|186801|2721107|2721132;2|1783272|1239|186801;2|3379134|976|200643|171549|815|816|291645;2|1783272|201174|1760|85004|31953|1678|1694;2|1783272|201174|1760|85004|31953|1678|78448,Complete,NA
-bsdb:1230/2/1,Study 1230,time series / longitudinal observational,39481388,10.1016/j.chom.2024.10.006,NA,"Macandog ADG, Catozzi C, Capone M, Nabinejad A, Nanaware PP, Liu S, Vinjamuri S, Stunnenberg JA, Galiè S, Jodice MG, Montani F, Armanini F, Cassano E, Madonna G, Mallardo D, Mazzi B, Pece S, Tagliamonte M, Vanella V, Barberis M, Ferrucci PF, Blank CU, Bouvier M, Andrews MC, Xu X, Santambrogio L, Segata N, Buonaguro L, Cocorocchio E, Ascierto PA, Manzo T , Nezi L",Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients,Cell host & microbe,2024,"antigen mimicry, gut microbiome, immunotherapy, longitudinal, melanoma",Experiment 2,Italy,Homo sapiens,Feces,UBERON:0001988,Melanoma,EFO:0000756,non-complete responders (nCR),complete responders (CR),This group represents the Complete Responders (CR) to anti-PD-1 therapy in melanoma patients for 7-13 months (late therapy).,14,23,30 days,WMS,NA,Illumina,MaAsLin2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 1,S1B,27 November 2024,Joiejoie,Joiejoie,Highlights the longitudinal profiling of gut microbiota changes associated with treatment response. It compares the stable taxa identified in complete responders (CR) and non-complete responders (nCR) at various time points throughout the therapy.,increased,NA,NA,Complete,NA
+bsdb:1230/1/1,Study 1230,time series / longitudinal observational,39481388,10.1016/j.chom.2024.10.006,NA,"Macandog ADG, Catozzi C, Capone M, Nabinejad A, Nanaware PP, Liu S, Vinjamuri S, Stunnenberg JA, Galiè S, Jodice MG, Montani F, Armanini F, Cassano E, Madonna G, Mallardo D, Mazzi B, Pece S, Tagliamonte M, Vanella V, Barberis M, Ferrucci PF, Blank CU, Bouvier M, Andrews MC, Xu X, Santambrogio L, Segata N, Buonaguro L, Cocorocchio E, Ascierto PA, Manzo T , Nezi L",Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients,Cell host & microbe,2024,"antigen mimicry, gut microbiome, immunotherapy, longitudinal, melanoma",Experiment 1,Italy,Homo sapiens,Feces,UBERON:0001988,Melanoma,EFO:0000756,non-complete responders (nCR),complete responders (CR),This group represents the Complete Responders (CR) to anti-PD-1 therapy in melanoma patients for 2-6 months (early therapy) .,14,23,30 days,16S,34,Illumina,MaAsLin2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 1,Figure S2D,19 November 2024,Joiejoie,Joiejoie,This figure highlights the microbial taxa that demonstrated an increase in relative abundance from baseline to therapy in patients with CR.,increased,"k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Bacteroides|s__Bacteroides nordii,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pseudolongum,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Bifidobacteriales|f__Bifidobacteriaceae|g__Bifidobacterium|s__Bifidobacterium pullorum,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia",2|3379134|976|200643|171549|815|816|291645;2|1783272|201174|1760|85004|31953|1678|1694;2|1783272|201174|1760|85004|31953|1678|78448;2|1783272|1239|186801|2721107|2721132;2|1783272|1239|186801,Complete,NA
+bsdb:1230/2/1,Study 1230,time series / longitudinal observational,39481388,10.1016/j.chom.2024.10.006,NA,"Macandog ADG, Catozzi C, Capone M, Nabinejad A, Nanaware PP, Liu S, Vinjamuri S, Stunnenberg JA, Galiè S, Jodice MG, Montani F, Armanini F, Cassano E, Madonna G, Mallardo D, Mazzi B, Pece S, Tagliamonte M, Vanella V, Barberis M, Ferrucci PF, Blank CU, Bouvier M, Andrews MC, Xu X, Santambrogio L, Segata N, Buonaguro L, Cocorocchio E, Ascierto PA, Manzo T , Nezi L",Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients,Cell host & microbe,2024,"antigen mimicry, gut microbiome, immunotherapy, longitudinal, melanoma",Experiment 2,Italy,Homo sapiens,Feces,UBERON:0001988,Melanoma,EFO:0000756,non-complete responders (nCR),complete responders (CR),This group represents the Complete Responders (CR) to anti-PD-1 therapy in melanoma patients for 7-13 months (late therapy).,14,23,30 days,WMS,NA,Illumina,MaAsLin2,0.05,TRUE,NA,NA,NA,NA,NA,NA,NA,NA,NA,Signature 1,S2D,27 November 2024,Joiejoie,Joiejoie,Differential abundance of CR (blue),increased,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|g__Candidatus Metalachnospira|s__Candidatus Metalachnospira gallinarum,2|1783272|1239|186801|2721107|2721132,Complete,NA
 bsdb:1231/1/1,Study 1231,time series / longitudinal observational,36639731,10.1038/s41598-023-27555-x,NA,"Asangba AE, Chen J, Goergen KM, Larson MC, Oberg AL, Casarin J, Multinu F, Kaufmann SH, Mariani A, Chia N , Walther-Antonio MRS",Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response,Scientific reports,2023,NA,Experiment 1,United States of America,Homo sapiens,"Vagina,Uterine cervix","UBERON:0000996,UBERON:0000002",Ovarian cancer,MONDO:0008170,Benign,Ovarian cancer,Ovarian cancer refers to women with Ovarian cancer who are currently undergoing hysterectomy,30,34,2 weeks,16S,345,Illumina,Linear Regression,0.1,TRUE,NA,NA,"body mass index,menopause",NA,unchanged,NA,NA,unchanged,increased,Signature 1,"Fig. 2M, Supplementary Table 1, Supplementary Table 3",16 December 2024,KateRasheed,KateRasheed,"Differential abundance of taxa between Benign and Ovarian cancer patients, gotten from Lower reproductive tract (vaginal and cervical samples)",increased,"k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium|s__Corynebacterium tuberculostearicum,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia|s__Facklamia hominis,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__Mediterraneibacter faecis,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Mediterraneibacter|s__[Ruminococcus] torques,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia",2|1783272|201174|1760|85007|1653|1716|38304;2|1783272|1239|91061|186826|186827|66831|178214;2|1783272|1239|186801|3085636|186803|2316020|592978;2|1783272|1239|186801|3085636|186803|2316020|33039;2|1783272|201174|1760|85007|1653|1716;2|1783272|1239|91061|186826|186827|66831,Complete,Svetlana up
 bsdb:1231/2/1,Study 1231,time series / longitudinal observational,36639731,10.1038/s41598-023-27555-x,NA,"Asangba AE, Chen J, Goergen KM, Larson MC, Oberg AL, Casarin J, Multinu F, Kaufmann SH, Mariani A, Chia N , Walther-Antonio MRS",Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response,Scientific reports,2023,NA,Experiment 2,United States of America,Homo sapiens,Ovary,UBERON:0000992,Ovarian cancer,MONDO:0008170,Benign,Ovarian cancer,Ovarian cancer refers to women with Ovarian cancer who are currently undergoing hysterectomy,30,34,2 weeks,16S,345,Illumina,Linear Regression,0.1,TRUE,NA,NA,"body mass index,menopause",NA,unchanged,NA,NA,unchanged,unchanged,Signature 1,"Fig. 2N, Supplementary Table 1, Supplementary Table 3",16 December 2024,KateRasheed,KateRasheed,"Differential abundance of taxa between Benign and Ovarian cancer patients, gotten from the ovaries",decreased,"k__Bacteria|k__Bacillati|p__Actinomycetota,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Micrococcales|f__Microbacteriaceae|g__Microbacterium|s__Microbacterium lacus",2|1783272|201174;2|1783272|201174|1760|85006|85023|33882|415217,Complete,Svetlana up
 bsdb:1231/3/1,Study 1231,time series / longitudinal observational,36639731,10.1038/s41598-023-27555-x,NA,"Asangba AE, Chen J, Goergen KM, Larson MC, Oberg AL, Casarin J, Multinu F, Kaufmann SH, Mariani A, Chia N , Walther-Antonio MRS",Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response,Scientific reports,2023,NA,Experiment 3,United States of America,Homo sapiens,Peritoneal fluid,UBERON:0001268,Ovarian cancer,MONDO:0008170,Benign,Ovarian cancer,Ovarian cancer refers to women with Ovarian cancer who are currently undergoing hysterectomy,30,34,2 weeks,16S,345,Illumina,Linear Regression,0.1,TRUE,NA,NA,"body mass index,menopause",NA,unchanged,NA,NA,unchanged,unchanged,Signature 1,"Fig. 2O, Supplementary Table 1, Supplementary Table 3",16 December 2024,KateRasheed,KateRasheed,"Differential abundance of taxa between Benign and Ovarian cancer patients, gotten from Ascites/Peritoneal fluid",increased,"k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Hyphomicrobiales|f__Methylobacteriaceae|g__Methylorubrum|s__Methylorubrum extorquens,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Hyphomicrobiales|f__Methylobacteriaceae|g__Methylobacterium",2|3379134|1224|28211|356|119045|2282523|408;2|3379134|1224|28211|356|119045|407,Complete,Svetlana up