gold_data_split_2.json

[
    {
        "id": "report35015",
        "sentences": [
            "Reviewer response for version 1",
            "The authors present an analysis of birth defects by season from a single hospital in an unnamed West African country relative to a purported mosquito season. ",
            "Their conclusion is that the seasonality of certain types of birth defects, consistent with CZS, could be explain by Zika virus transmission in the area. ",
            "This is an interesting attempt to use available data to speculate about the impact of Zika virus on congenital defects in an endemic area. ",
            "Although this is certainly thought-provoking and supports the authors recommendation to improve surveillance for Zika virus in endemic areas, there is insufficient discussion of all of the limitations to this particular analysis which, if included, would cast doubt on their proposed conclusion.",
            "The limitation that the data are from a single hospital in an un-named location make it impossible to make any generalizable conclusions and to understand any limitations completely.",
            "Data do not exist on the underlying sero-prevalence of Zika virus infection in this population (I assume). ",
            "However, given that Zika virus infection likely results in lifelong immunity, one might not expect to see any change in CZS-like defects simply due to a low number of susceptible pregnant women. ",
            "Were the women with infants with birth defects generally younger and therefore less likely to have been previously infected? ",
            "And why wouldn't we expect children to have a high rate of infection resulting in immunity as they reach child-bearing age?",
            "Again, although difficult to determine given the lack of geographic specificity provided, there is minimal discussion in the paper of other potential causes of microcephaly; most notably rubella and malnutrition. ",
            "Although rubella-related birth defects might not be expected to show any seasonality, malnutrition might. ",
            "As might toxoplasmosis.",
            "The time period covered by this report encompasses both the Ebola outbreak and significant Yellow fever activity; both of these could cause confounding in the data.",
            "Mosquito species are quite variable in their feeding habits, optimal climactic conditions and in their vectorial capacity. ",
            "Relying on patterns of malarial disease to represent what is likely to happen with a flavivirus like Zika which is transmitted by different species of mosquitoes should be considered to be a limitation. ",
            "What about using Yellow fever or dengue disease patterns?",
            "Lastly, while I understand the argument the authors are making, I found the assertion that the maternal infection period of August through October encompassed the peak and latter half of the warm, rainy season confusing. ",
            "Based on the presented data, August through October had minimal rain and lower than average temperatures. ",
            "October through December was described as the cool, dry season although temperatures peak for the year in November through January (according to the data presented by the authors)."
        ],
        "labels": [
            "Structure",
            "Recap",
            "Recap",
            "Strength",
            "Weakness",
            "Weakness",
            "Other",
            "Other",
            "Todo",
            "Todo",
            "Weakness",
            "Other",
            "Other",
            "Weakness",
            "Other",
            "Weakness",
            "Todo",
            "Weakness",
            "Recap",
            "Weakness"
        ],
        "pid": "7-159",
        "domain": "diso"
    },
    {
        "id": "report15505",
        "sentences": [
            "Reviewer response for version 1",
            "Below my considerations. ",
            "I believe that the article can be indexed with minor adjustments.",
            "I do not agree with the statement: \"In the last decades, Brazil has faced different arbovirus epidemics. However, none of them had the complexity of Zika virus and associated diseases\". ",
            "Dengue has caused and still causes serious public health and has much higher mortality rate in Brazil.",
            "The article cites many epidemiological bulletin of the Ministry of Health. ",
            "This is important, but it has some articles that deserve to be mentioned. ",
            "As an example, we have published papers citing cases of zika in Brazil (RN and BA) before the publication of the Ministry of Health report.",
            "Even with all the advances cited by the authors I believe that it is necessary to mention the delay in the release of funds for research on zika in Brazil."
        ],
        "labels": [
            "Structure",
            "Structure",
            "Other",
            "Weakness",
            "Other",
            "Recap",
            "Todo",
            "Other",
            "Todo"
        ],
        "pid": "5-1915",
        "domain": "diso"
    },
    {
        "id": "report57787",
        "sentences": [
            "Reviewer response for version 1",
            "Summary :",
            "Australia\u2019s influenza season does not typically coincide with school holidays. ",
            "However, in 2019, the influenza season occurred earlier than usual, allowing the opportunity to evaluate the impacts of school closure on influenza dynamics in Australia. ",
            "In this article, the authors present state and territory-level influenza data by week, and perform segmented regression, comparing influenza incidence before and after the school holiday. ",
            "They also count weekly increases and decreases before, during, and after the school holiday, and show age-based dynamics. ",
            "This article asks an important question of public health relevance to non-pharmaceutical interventions in a setting where it has not been previously investigated in a concise manner. ",
            "However, this article could be strengthened through additional framing, increased statistical rigor, and more nuanced interpretation.",
            "Comments :",
            "- The introduction leaves several unanswered questions that would help to more clearly identify the importance of the study. ",
            "The relationship between school closure and influenza dynamics has been explored in a number of previous papers, with both epidemiological data and mechanistic models. ",
            "Thus, it is unclear to me why is it important to consider this relationship in Australia, specifically. ",
            "Do the authors have hypotheses regarding trends or mechanisms that might be different from other countries? ",
            "Is it important for public health planning? ",
            "This question seems especially salient to me since school closures and the influenza season in Australia do not typically coincide, so these epidemiological trends may not be typical for Australia.\n",
            "- The article concludes that there is a significant reduction in influenza in most states in Australia based on the results of segmented regression comparing influenza incidence level and slope before and after the holiday period. ",
            "I am not totally convinced by this conclusion, as Table 1 shows that the change in level is not significant for Victoria, Australian Capital Territory, and Southern Australia, and the change in slope is not significant for Queensland, Victoria, Western Australia, and Southern Australia. ",
            "This is contrary to the section of the results that states that \u201cthe estimates for the initial effect and the subsequent slope show significant declines for all states except South Australia\u201d. ",
            "These results could be more carefully interpreted. ",
            "This would give rise to an interesting question: what are the differences between the states/territories that result in different dynamics?\n",
            "- I think this article could be strengthened with a more robust time series modeling approach, like ARIMA modeling. ",
            "This would be particularly useful because the predicted vs. residual plot in Appendix 4 appears to indicate heteroskedasticity in the data. ",
            "Including model terms in a time series model could handle this issue, as well as temporal autocorrelation.\n",
            "- The results also provide the percent of weeks in the pre-vacation, during-vacation, and post-vacation period in which there is a weekly decrease in influenza incidence, indicating that there is a higher proportion of decreases in the during and post-vacation period. ",
            "However, the pre-vacation period seems to include all of the early part of the season. ",
            "If there were numerous decreases in this time period, then the onset of the influenza season would not have occurred. ",
            "Thus, this finding may be a bit circular.\n",
            "- It would be useful to compare this influenza season, which co-occurs with the holiday period, with another influenza season that does not co-occur with the holiday period, as a control. ",
            "This could help to isolate the impact of school closure on influenza dynamics.\n",
            "- The authors specify mid-May to early September as their study period. ",
            "However, it\u2019s unclear what total population and age-specific dynamics looked like post week 35. ",
            "Past studies have shown that school holidays simply delay dynamics so that the epidemic wave recovers to pre-holiday rates after the holiday. ",
            "I would be curious if this is the case here.\n",
            "- In the model, a one-week lag was assumed. ",
            "Is there evidence about care-seeking and influenza surveillance/reporting to support this? ",
            "The discussion mentions a sensitivity analysis performed with no lag, but I wonder if the lag could be longer due to a combination of delay to seeking healthcare and delay in reporting.\n",
            "- The fourth paragraph of the discussion comments on the possible causes of the association between school closure and influenza. ",
            "This paragraph rules out several possible explanations but does not then provide a plausible explanation.",
            "Minor comments:",
            "- A y-axis label on Figure 1 and Figure 2 would be helpful. ",
            "The Figure 1 caption says it is the influenza rate, so I assume it is influenza cases per week, but this could be clearer.\n",
            "- Is the x-axis in Figure 2 the week number? ",
            "It would be easier to interpret if it was put into the same units as Figure 1, with dates instead of week counts.\n",
            "- Does Figure 2 include cases for all of the states and territories combined?\n",
            "- In Table 1, it is unclear whether the changes described (in both slope and level) are comparing the during-vacation period or the post-vacation period to the pre-vacation period. ",
            "The observed and predicted plots in Appendix 3 appear to show 3 different segments fit for each of these periods, but it is unclear what change is reported in Table 1."
        ],
        "labels": [
            "Structure",
            "Structure",
            "Other",
            "Other",
            "Recap",
            "Recap",
            "Strength",
            "Todo",
            "Structure",
            "Weakness",
            "Other",
            "Weakness",
            "Todo",
            "Todo",
            "Other",
            "Recap",
            "Weakness",
            "Weakness",
            "Todo",
            "Todo",
            "Todo",
            "Recap",
            "Todo",
            "Recap",
            "Recap",
            "Other",
            "Weakness",
            "Todo",
            "Other",
            "Recap",
            "Weakness",
            "Other",
            "Todo",
            "Recap",
            "Todo",
            "Todo",
            "Recap",
            "Weakness",
            "Structure",
            "Todo",
            "Todo",
            "Todo",
            "Weakness",
            "Todo",
            "Weakness",
            "Weakness"
        ],
        "pid": "8-1899",
        "domain": "diso"
    },
    {
        "id": "report30694",
        "sentences": [
            "Reviewer response for version 1",
            "I had difficulty reading the tables in the article. ",
            "I thought maybe it was the way they were displaying on my computer, but nothing seemed to change when I clicked on them. ",
            "Please make these charts simple to read and clear. ",
            "I need to see the tables to make sure your findings are adequately described.",
            "The article is really well written. ",
            "I was very pleased with the quality of the writing and the honesty of the authors about their challenges. ",
            "This is important work in the area of PPE use.",
            "While I know that this was quick work in a difficulty setting, I still feel like the article needs to do justice to personal protective equipment research of the past 20 years (at least since SARS). ",
            "The major section that needs more referencing is the discussion section. ",
            "How do your findings compare to what we have found in epidemiological studies, simulation studies, and others on PPE. ",
            "Even if these studies were not done in the context of an outbreak of EVD in Africa, they should still be discussed. ",
            "There is literature on some of these areas that would bring worthwhile context to your findings."
        ],
        "labels": [
            "Structure",
            "Weakness",
            "Other",
            "Todo",
            "Other",
            "Strength",
            "Strength",
            "Strength",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Other"
        ],
        "pid": "7-45",
        "domain": "diso"
    },
    {
        "id": "report36897",
        "sentences": [
            "Reviewer response for version 1",
            "The authors report on the usage of IDPs by postdoctoral scholars, which is both a timely and fundamental topic within the broader graduate and postdoctoral professional development community. ",
            "This work extends beyond the authors\u2019 recently published article on IDP usage among doctoral students 1 to showcase how the instrument is currently being used by postdocs. ",
            "The aforementioned manuscript on doctoral IDP usage extensively discusses policy and other issues surrounding IDPs, while this manuscript is lean on discussion. ",
            "It would therefore benefit from including prior literature on correlates of success associated with postdocs who have written plans\u2014which would have the added benefit of placing this work into a broader context (for example, see: Davis 2009 2 ).",
            "There are a number of points that should be addressed, and they are outlined as follows:",
            "- The survey instrument asks questions on a 5-point Likert scale of strongly agree, agree, neutral (neither agree nor disagree), disagree, & strongly disagree. ",
            "However, when analyzing the data, the authors report percentages either as \u2018does not agree\u2019 (also reported as \u2018disagree\u2019) or \u2018agree\u2019 - with \u2018strongly disagree, disagree & neutral\u2019 all grouped together as a \u2018does not agree\u2019 response. ",
            "It seems that lumping \u201cneutral (neither agree nor disagree)\u201d into the \u2018does not agree\u2019 category would skew results (both in this manuscript and the manuscript on doctoral IDP usage) towards \u2018does not agree.\u2019 ",
            "It is recommended that the authors reanalyze the data and report the \u2018neutral\u2019 responses as a third category in order to more accurately reflect intended answers/percentages.\n",
            "- I agree with reviewer 1 that it is unclear how the authors calculated that 54% completed an IDP; like reviewer 1, I also calculated that 61% completed an IDP either with or without their PI. ",
            "Similarly, I also agree with reviewer 1 that it is unclear where the 38.4% value came from (percent of respondents that completed an IDP who found the tool helpful). ",
            "Furthermore, in figure 1, a value of 22.4% of all respondents (whether they complete an IDP or not) is listed as saying the IDP process is helpful to their career development. ",
            "Since \u201c22.4%\u201d also includes those who never completed an IDP, reporting it in this manner seems to bias perceptions of the tool as unhelpful.\n",
            "- Aside from the unclear derivation of percentages discussed in point #2, the questions in the survey instrument do not seem to allow confident discernment of who actually completed an IDP. ",
            "For example, respondents who disagree with the question \u201cI complete an IDP annually with my PI/advisor\u201d could have actually completed an IDP with their PI at the beginning of their postdoc and/or possibly in year 3 of their postdoc\u2014how much weight were respondents giving to the word \u2018annually\u2019? ",
            "Another question reads: \u201cI complete an IDP but I do not discuss it with my PI/advisor\u201d - could respondents complete two different IDPs - one with and one without their PI (and thus agree to both the former and latter questions)?\n",
            "- The authors assert that the usefulness of an IDP has decreased since 2014, specifically comparing their results to that in (Hobin et al. 2014 3 ). ",
            "However, in the (Hobin et al. 2014) paper, an IDP\u2019s overall value is reported either as \u2018not helpful\u2019 \u2018neutral\u2019 or \u2018helpful\u2019. ",
            "It seems that the results in this manuscript could be compared more accurately with the (Hobin et al. 2014) data by showing the \u2018neutral\u2019 responses, rather than lumping them with \u2018does not agree\u2019 (see point 1 above). ",
            "Additionally, it would be helpful to point out the limitations of comparing these two studies (ex: address key differences between the two survey instruments regarding how the IDP questions were asked (and how this might bias responses), address potential respondent audience differences, etc.).\n",
            "- Like reviewer 1, I also feel that there are limited questions that address what one might consider IDP \u2018effectiveness.\u2019",
            "\u2019 The manuscript would thus be strengthened by discussing IDP indicators that have been previously reported in the literature (such as measures outlined by (Hobin et al. 2014) - ex: the value of an IDP in helping with self-assessment, helping identify career paths, helping identify skills to strengthen, etc.). ",
            "Furthermore, (Davis 2009 2 ) reports an in-depth analysis of results from a Sigma Xi Postdoc Survey - identifying many positive correlates of success associated with postdocs who develop a written plan at the outset of their careers (ex: higher publication rate, grant submission rate, better supervisor relationships, etc.). ",
            "Since the main point of this manuscript is to discuss the use and effectiveness of IDPs among postdocs, it would benefit from elaborating upon such postdoc-specific contextual literature - as well as other literature that documents the general benefits of goal-setting, which is a primary function of IDPs (Locke et al. 2002 4 ).\n",
            "- (Minor) The authors indicate that \u201cadditional research is needed,\u201d and it would thus be beneficial to clarify the research questions that should be addressed. ",
            "For example, it seems that it would be useful to determine the effects of various parameters on IDP effectiveness such as: 1) when in training an IDP is completed; 2) inclusion/ exclusion of IDP components (such as self-assessment, career exploration, skill-building, goal-setting, etc.); 3) prior experience with/completion of an IDP as a PhD student; 4) completing an IDP of their own accord versus doing so because it is required; 5) receiving training on how to create/implement an IDP; 6) using a specific IDP instrument (ex: myIDP) versus an institutionally-developed IDP, etc..\n",
            "- (Minor) ",
            "As an additional point - since \u2018IDP effectiveness\u2019 is subjective as the authors point out, perhaps future studies should address better-defining these parameters so that common IDP evaluation methods can be adopted within the broader community. ",
            "It would also be especially helpful to ascertain what IDP tools are being used, and how they are being implemented so that standard \u2018correlates of effectiveness\u2019 could be tied to specific IDP instruments (or components) and the manner in which they are employed."
        ],
        "labels": [
            "Structure",
            "Strength",
            "Recap",
            "Other",
            "Todo",
            "Structure",
            "Recap",
            "Recap",
            "Weakness",
            "Todo",
            "Weakness",
            "Weakness",
            "Recap",
            "Weakness",
            "Weakness",
            "Todo",
            "Todo",
            "Recap",
            "Weakness",
            "Todo",
            "Todo",
            "Weakness",
            "Todo",
            "Other",
            "Todo",
            "Todo",
            "Todo",
            "Structure",
            "Todo",
            "Other"
        ],
        "pid": "7-1132",
        "domain": "scip"
    },
    {
        "id": "report71864",
        "sentences": [
            "Reviewer response for version 1",
            "In this paper, the authors developed \u201cspace-log\u201d, a new method to infer gene-gene network (GGN), by incorporating log penalty into the \u201cspace\u201d method. ",
            "The authors compared their method to the original \u201cspace\u201d with LASSO penalty and the neighborhood selection (NS) methods, using simulation and real data. ",
            "In general, the description of the proposed method is clear, and the simulation and real application settings made sense. ",
            "However, I believe this paper needs to be revised to (1) provide the rationale for choosing the combination of \u201cspace\u201d and log penalty, (2) compare with more state-of-the-art methods, and (3) improve the presentation and writing. ",
            "Here are some specific comments.",
            "- The authors need to discuss why they decided to combine \u201cspace\u201d and log penalty for GGN detection. ",
            "What is the benefit of using log penalty over other penalty choices, including concave penalties and other nonconcave penalties such as SCAD, MCP, and TLP? ",
            "The introduction should be extended to include more state-of-the-art methods, such as adaptive LASSO or high-dimensional regression methods with sparse precision matrix estimation.\n",
            "- Although briefly mentioned gLasso in the introduction, the authors did not talk about this class of methods in the rest of the paper. ",
            "I am curious to see how space-log compares to gLasso and its extensions with nonconcave penalties in simulation and real application (see Fan et al. , 2009). 1\n",
            "- Based on my understanding, the major benefit of using nonconcave penalties is to reduce the estimation bias of the correlation coefficients. ",
            "I suggest the authors include comparisons based on the coefficient estimation. ",
            "In addition, the authors should provide details about how the precision matrices are simulated. ",
            "Currently, only the simulation methods for its bone structure are provided.\n",
            "- In conclusion/discussion, the authors should provide more insights or heuristics about why the proposed method performed better than other methods. ",
            "What aspects of the data makes the proposed method favorable? ",
            "Is there any limitation that the users should pay attention to when applying this method in application?",
            "Minor comments:",
            "- The citations in this paper are apparently converted from an author-year citation format. ",
            "The authors need to make changes to the writing to adapt to numbered citation format.\n",
            "- Presentation and writing issues, for example:",
            "- The authors need to decide if a comma is needed between two subscripts in the notation (e.g. \\beta_{ij} or \\beta_{i,j} on page 3 left column).\n",
            "- On page 4, left column, third paragraph, the sentence \u201cThe initial paragraph \u2026\u201d only applies to BA model, but not ER model.\n",
            "- Also, it should be \u201cin the (t+1)th step\u201d instead of \u201cin the (k+1)th step\u201d.\n",
            "- In the last sentence of this paragraph, it should be \u201c1/m\u201d and \u201c2/m\u201d.\n",
            "- This is not an exhaustive list of writing issues. ",
            "I suggest the authors proofread carefully."
        ],
        "labels": [
            "Structure",
            "Recap",
            "Recap",
            "Strength",
            "Todo",
            "Structure",
            "Todo",
            "Todo",
            "Todo",
            "Weakness",
            "Todo",
            "Other",
            "Todo",
            "Todo",
            "Recap",
            "Todo",
            "Todo",
            "Todo",
            "Structure",
            "Other",
            "Todo",
            "Structure",
            "Todo",
            "Weakness",
            "Todo",
            "Todo",
            "Other",
            "Todo"
        ],
        "pid": "9-1159",
        "domain": "rpkg"
    },
    {
        "id": "report49169",
        "sentences": [
            "Reviewer response for version 1",
            "The paper by Boulton and Lenton \u201cA new method for detecting abrupt shifts in time series\u201d proposes an alternative to the previously published change-point techniques (methodology and R package software).",
            "I think the paper is interesting and can be indexed after revision. ",
            "In particular, the authors may be interested to look at the recent paper: Beaulieu C. and R. Killick (2018) 1 and the corresponding software package \u2018EnvCpt\u2019 that performs automatic selection between a variety of trends, changepoints and autocorrelation models, found here .",
            "On page 2, the authors mention that the red noise \u201ccan produce what appears as abrupt shift in time series, although it is debated whether they should be described as such\u201d. ",
            "A time series with a dynamically changing scaling exponent of red noise actually provides the underlying mechanism of a gradual tipping, as confirmed by several indicators for early warning signals (see Prettyman et al. , EPL 2018 2 ). ",
            "This should be distinguished from the red noise with a single fixed scaling exponent that does not change with time (and that may be the case of absence of a tipping point). ",
            "This needs to be discussed more clearly, otherwise an unprepared reader could be misled regarding the role of memory in tipping dynamics. ",
            "In particular, this should be better described in the Abstract (or removed from there for simplicity).",
            "Since the object of analysis is a single-variable time series, the authors actually calculate not gradient (which is by definition multi-variate) but a discrete derivative in each subset of data.",
            "It would be good to see a systematic ensemble experiment estimating the success rate of the technique performance for a range of: jumps heights at change points (with respect to the series noise level), lengths of time series, and window sizes (similar to Fig.2 but in a broader range of parameters and with summary over multiple samples rather than a few examples).",
            "It is not clear to me why the detection series is always within the interval [-1,1] \u2013 do the authors normalise this series? ",
            "On page 2, the authors say that they \u201cadd or subtract 1 to the relevant l-long segments of a detection time series which contains only 0s otherwise\u201d- but in (Fig.2f,i) there are also non-zero and non-one values, why?",
            "The discussion of the threshold choice could be improved for better clarity, in my opinion. ",
            "Maybe some diagram could help visually here."
        ],
        "labels": [
            "Structure",
            "Recap",
            "Strength",
            "Todo",
            "Recap",
            "Other",
            "Other",
            "Todo",
            "Todo",
            "Recap",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Todo"
        ],
        "pid": "8-746",
        "domain": "rpkg"
    },
    {
        "id": "report55176",
        "sentences": [
            "Reviewer response for version 1",
            "The workflowr package, available from CRAN for 1.5 years, has already demonstrated itself to be a valuable contribution to improving the reproducibility of scientific analyses. ",
            "This paper does a thorough job setting out the rationale, design, and implementation of the workflowr package. ",
            "It is clear that the authors have spent considerable time thinking about some of the key challenges of this endeavour, learning about best practises, getting feedback from users, and implementing these using 4 key technologies/features:",
            "- Version control.\n",
            "- Literate programming.\n",
            "- Automatic checks and safeguards to improve code reproducibility.\n",
            "- Sharing code and results via a website.",
            "The paper is clearly written and I am happy to approve the article in its current form.",
            "Some minor comments, queries, and corrections are given below:",
            "- Figure caption 1: '\"analyses\" folder' is '\"analysis\" folder' in the figure.\n",
            "- p5: Re workflowr executing code in a clean session. ",
            "My impression was that rendering Rmarkdown documents, at least when done by clicking the 'knit' button in RStudio, was already run in a separate process. ",
            "But I may be mistaken and perhaps this is different from running `rmarkdown::render_site()`?\n",
            "- Regarding published sites. ",
            "Not all scientific analyses can be made public, particularly in the early stages. ",
            "Some discussion of options available for private/protected hosting would be valuable.\n",
            "- I'm a little wary of relying on raw.githack.com for hosting past versions of the webpages. ",
            "For example, what if the service becomes unavailable? ",
            "Does or could workflowr support other hosting services?\n",
            "- p11: Is the idea of a 'centralized workflowr project website' like that of the homepage https://bookdown.org/ or for an organisation/user to share their personal workflowr projects?"
        ],
        "labels": [
            "Structure",
            "Other",
            "Strength",
            "Strength",
            "Recap",
            "Recap",
            "Recap",
            "Recap",
            "Strength",
            "Structure",
            "Weakness",
            "Structure",
            "Other",
            "Todo",
            "Structure",
            "Other",
            "Todo",
            "Weakness",
            "Other",
            "Todo",
            "Todo"
        ],
        "pid": "8-1749",
        "domain": "rpkg"
    },
    {
        "id": "report14175",
        "sentences": [
            "Reviewer response for version 1",
            "Though the authors distinguish dominant (DDEB) and recessive (RDEB) subtypes of dystrophic epidermolysis bullosa (DEB) at the outset in their abstract, they lapse into speaking of DEB in more monolithic terms later and conflating findings that are specific in some cases only to one subtype. ",
            "There is a reason for this as there is considerable overlap but there are differences particularly with certain features like the propensity for developing skin cancer. ",
            "The authors state \"the development of skin cancer....in almost all affected members in the third or fourth decade of life.\" ",
            "This is true for RDEB phenotype but not DDEB in whom the development of squamous cell carcinoma as well as the distinctive psuedosyndactyly type of scarring much less common. ",
            "This may not be the forum for parsing such details but this struck me.",
            "Similarly, while I realize this is not an EB review article a brief internal reference to the Vander Oever article might allow interested readers easy access to a therapeutic update.",
            "Finally, I would want someone other than I with expertise in the genetic methods used to weigh in on their suitability. ",
            "The methods and results to my untrained --relative to a geneticist--- eye appear sound.",
            "Otherwise I approve indexing this article."
        ],
        "labels": [
            "Structure",
            "Weakness",
            "Other",
            "Recap",
            "Weakness",
            "Other",
            "Todo",
            "Other",
            "Strength",
            "Other"
        ],
        "pid": "5-900",
        "domain": "case"
    },
    {
        "id": "report3725",
        "sentences": [
            "Reviewer response for version 1",
            "This is an interesting paper and is well written. ",
            "It would definitely help future clinicians who might encounter this rare diagnosis. ",
            "However I think that for the benefit of these clinicians the authors should include more details on the chemotherapy regimen, including the number of days ifosfamide was administered for and the frequency of the cycle. ",
            "More details about the surgery and radiation would also be helpful."
        ],
        "labels": [
            "Structure",
            "Strength",
            "Strength",
            "Todo",
            "Todo"
        ],
        "pid": "3-15",
        "domain": "case"
    },
    {
        "id": "report44458",
        "sentences": [
            "Reviewer response for version 1",
            "This is an interesting case report which discusses a rare phenomenon of unprovoked venous thromboembolism and its management. ",
            "I would congratulate the authors for their work. ",
            "However, there are a few concerns:",
            "Though the authors have mentioned that there was no history of long air travel, it will be helpful to know if the patient had any history of long car travel before the event precipitated. ",
            "It has been noted that DVT is commonly encountered in patients who undergo long car travel. ",
            "Such information, if added, shall make the physicians more aware.",
            "Did the physicians/authors conduct any clinical examination to test DVT. ",
            "Were Homan's or Mosses sign performed. ",
            "If yes, what were the results. ",
            "If not, it will be helpful to know the reason for not performing them. ",
            "A little detail on clinical examination of the patient should also be added to the manuscript besides the symptoms and findings.",
            "It will also be helpful to know the Trop I values, if they were assessed by the authors.",
            "The authors have mentioned that patient was kept on Rivaroxaban. ",
            "Were there any side effects that were encountered. ",
            "It will also be helpful if the authors could mention about the follow-up period of the patient in the manuscript.",
            "Was any assessment done in the post discharge period. ",
            "Was there any change in vessel size? ",
            "Any adaptive remodeling seen with the treatment using Rivaroxaban .",
            "Was the patient satisfied with the treatment? ",
            "Any satisfaction index which was assessed. ",
            "Authors may add it if found to be appropriate. ",
            "They could use the attached reference for the same."
        ],
        "labels": [
            "Structure",
            "Strength",
            "Strength",
            "Structure",
            "Todo",
            "Other",
            "Other",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Recap",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Todo",
            "Other",
            "Todo",
            "Todo"
        ],
        "pid": "8-182",
        "domain": "case"
    },
    {
        "id": "report20355",
        "sentences": [
            "Reviewer response for version 1",
            "Govindaraj et al. report a typical SCID patient with a known mutation in Rag1 (p.E770K) with a previously known defective recombination activity and thus, there is very little novel information in this manuscript. ",
            "In fact, the manuscript is already in itself published in F1000 (October 18th, 2016) and available on the web. ",
            "The mutation should simply be added to existing databases.",
            "Additional comments:",
            "- The figure should be improved \u2013 providing the different domains.\n",
            "- The pedigree (inheritance pattern is incomplete) - or simply state that the missing individuals were not sampled.\n",
            "- Introduction should be more focussed on Rag 1.\n",
            "- Immunization schedule (if any) for live vaccines could be of interest for the readers (but not necessary).\n",
            "- In the methods section, uniformity should apply (cc, mm ul etc). ",
            "The number of NK cells appear to be too high (higher than the total lymphocyte count).\n",
            "- Gene names should be in italics and transcript IDs should be given.\n",
            "- Abbreviations should be correctly used and introduced at the first time of presentation."
        ],
        "labels": [
            "Structure",
            "Weakness",
            "Other",
            "Todo",
            "Structure",
            "Todo",
            "Todo",
            "Todo",
            "Other",
            "Todo",
            "Recap",
            "Todo",
            "Todo"
        ],
        "pid": "5-2532",
        "domain": "case"
    }
]