From 9b31209a133cbac56844d115b1f68bafb0dce5b5 Mon Sep 17 00:00:00 2001 From: vicpaton Date: Wed, 3 Jul 2024 23:03:16 +0200 Subject: [PATCH] renamed conversors corneto<->networkx --- docs/src/vignettes/1_simple_example.ipynb | 4383 ++++++++++++++++++++- networkcommons/methods/_causal.py | 41 +- 2 files changed, 4228 insertions(+), 196 deletions(-) diff --git a/docs/src/vignettes/1_simple_example.ipynb b/docs/src/vignettes/1_simple_example.ipynb index 8c48c8f..f9dbad2 100644 --- a/docs/src/vignettes/1_simple_example.ipynb +++ b/docs/src/vignettes/1_simple_example.ipynb @@ -40,16 +40,7 @@ "cell_type": "code", "execution_count": 1, "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/home/victo/.local/lib/python3.10/site-packages/tqdm/auto.py:22: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", - " from .autonotebook import tqdm as notebook_tqdm\n" - ] - } - ], + "outputs": [], "source": [ "import networkcommons as nc\n", "import pandas as pd\n", @@ -69,27 +60,22 @@ "cell_type": "markdown", "metadata": {}, "source": [ - "We can see the available datasets using this util function. Currently only PANACEA is available, but the aim is to incorporate more perturbational datasets, from both transcriptomics and phosphoproteomics." + "We can see the available datasets using this util function. There are currently three big data sources included in NetworkCommons, but we aim to expand this by adding hundreds of experiments with different settings (perturbational, time-course, dose-response...) and of different nature (transcriptomics, phosphosproteomics...). For this vignette, we will use the PANACEA dataset:\n", + "\n", + "> Eugene F. Douglass et al., A community challenge for a pancancer drug mechanism of action inference from perturbational profile data. Cell Reports Medicine (2022). https://doi.org/10.1016/j.xcrm.2021.100492.\n", + "\n", + "PANACEA is a collection of perturbational transcriptomics profiles of 32 drugs and 11 cell lines\n", + "Contains raw count matrix and metadata\n", + "\n" ] }, { "cell_type": "code", "execution_count": 2, "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "['MOON', 'decryptm', 'panacea']" - ] - }, - "execution_count": 2, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ - "nc.get_available_datasets()" + "panacea_countdata, panacea_metadata = nc.data.omics.panacea()" ] }, { @@ -101,21 +87,10 @@ }, { "cell_type": "code", - "execution_count": 4, - "metadata": {}, - "outputs": [], - "source": [ - "panacea_data = nc.download_dataset('panacea')" - ] - }, - { - "cell_type": "code", - "execution_count": 8, + "execution_count": 3, "metadata": {}, "outputs": [], "source": [ - "panacea_countdata = panacea_data['panacea__countdata']\n", - "panacea_metadata = panacea_data['panacea__metadata']\n", "singlec_metadata = panacea_metadata[(panacea_metadata['group'] == 'ASPC_DMSO') | (panacea_metadata['group'] == 'ASPC_AFATINIB')]\n", "singlec_samples = singlec_metadata['sample_ID'].tolist()\n", "singlec_countdata = panacea_countdata[['gene_symbol'] + singlec_samples]" @@ -445,30 +420,34 @@ "name": "stderr", "output_type": "stream", "text": [ - "/home/victo/miniconda3/envs/networkcommons/lib/python3.10/site-packages/pydeseq2/dds.py:262: UserWarning: Some factor levels in the design contain underscores ('_').\n", + "/home/victo/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/pydeseq2/dds.py:264: UserWarning: Some factor levels in the design contain underscores ('_').\n", " They will be converted to hyphens ('-').\n", + " self.obsm[\"design_matrix\"] = build_design_matrix(\n", "Fitting size factors...\n", - "... done in 0.01 seconds.\n", + "... done in 0.03 seconds.\n", "\n", "Fitting dispersions...\n", - "... done in 36.70 seconds.\n", + "... done in 8.22 seconds.\n", "\n", "Fitting dispersion trend curve...\n", - "... done in 0.76 seconds.\n", + "... done in 0.64 seconds.\n", "\n", "Fitting MAP dispersions...\n", - "... done in 32.99 seconds.\n", + "... done in 8.62 seconds.\n", "\n", "Fitting LFCs...\n", - "... done in 4.77 seconds.\n", + "... done in 4.67 seconds.\n", + "\n", + "Calculating cook's distance...\n", + "... done in 0.09 seconds.\n", "\n", "Replacing 32 outlier genes.\n", "\n", "Fitting dispersions...\n", - "... done in 0.07 seconds.\n", + "... done in 0.03 seconds.\n", "\n", "Fitting MAP dispersions...\n", - "... done in 0.08 seconds.\n", + "... done in 0.04 seconds.\n", "\n", "Fitting LFCs...\n", "... done in 0.02 seconds.\n", @@ -485,15 +464,15 @@ "gene_symbol \n", "A1BG 0.000000 NaN NaN NaN NaN NaN\n", "NAT2 0.027355 0.659377 8.521128 0.077381 0.938320 NaN\n", - "ADA 4.059697 -2.335614 1.579921 -1.478311 0.139325 NaN\n", - "CDH2 0.101688 0.418908 5.154504 0.081270 0.935227 NaN\n", - "AKT3 0.114613 0.466998 5.289987 0.088280 0.929654 NaN\n", + "ADA 4.059697 -2.335471 1.579252 -1.478847 0.139181 NaN\n", + "CDH2 0.101688 0.418908 5.129245 0.081671 0.934909 NaN\n", + "AKT3 0.114613 0.466998 5.263457 0.088725 0.929301 NaN\n", "... ... ... ... ... ... ...\n", - "PTBP3 16.559153 0.265437 0.475929 0.557723 0.577033 NaN\n", + "PTBP3 16.559153 0.265500 0.475562 0.558286 0.576649 NaN\n", "KCNE2 0.000000 NaN NaN NaN NaN NaN\n", - "DGCR2 11.193327 -0.685015 0.678314 -1.009879 0.312553 NaN\n", - "CASP8AP2 9.318871 -0.410407 0.799604 -0.513263 0.607767 NaN\n", - "SCO2 15.866144 -0.390900 0.564794 -0.692111 0.488868 NaN\n", + "DGCR2 11.193327 -0.679913 0.687801 -0.988532 0.322892 NaN\n", + "CASP8AP2 9.318870 -0.410430 0.798973 -0.513696 0.607465 NaN\n", + "SCO2 15.866144 -0.390995 0.564523 -0.692611 0.488554 NaN\n", "\n", "[24961 rows x 6 columns]\n" ] @@ -502,13 +481,13 @@ "name": "stderr", "output_type": "stream", "text": [ - "... done in 2.09 seconds.\n", + "... done in 2.15 seconds.\n", "\n" ] } ], "source": [ - "results = nc.run_deseq2_analysis(singlec_countdata, singlec_metadata, test_group=\"ASPC_AFATINIB\", ref_group=\"ASPC_DMSO\")" + "results = nc.data.omics.deseq2(singlec_countdata, singlec_metadata, test_group=\"ASPC_AFATINIB\", ref_group=\"ASPC_DMSO\")" ] }, { @@ -525,7 +504,7 @@ "metadata": {}, "outputs": [], "source": [ - "decoupler_input = nc.decoupler_formatter(results, 'stat')\n", + "decoupler_input = nc._utils.decoupler_formatter(results, 'stat')\n", "collectri_net = dc.get_collectri()\n", "dc_estimates, dc_pvals = dc.run_ulm(decoupler_input, collectri_net)" ] @@ -543,7 +522,7 @@ "metadata": {}, "outputs": [], "source": [ - "measurements = nc.targetlayer_formatter(dc_estimates.T)" + "measurements = nc._utils.targetlayer_formatter(dc_estimates.T)" ] }, { @@ -566,8 +545,7 @@ "metadata": {}, "outputs": [], "source": [ - "network = nc.get_omnipath()\n", - "network.to_csv('network.csv', index=False)" + "network = nc.data.network.omnipath.get_omnipath()" ] }, { @@ -576,7 +554,7 @@ "metadata": {}, "outputs": [], "source": [ - "graph = nc.network_from_df(network)" + "graph = nc._utils.network_from_df(network)" ] }, { @@ -606,151 +584,4180 @@ ] }, { - "cell_type": "markdown", + "cell_type": "code", + "execution_count": 12, "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "OutEdgeDataView([('CALM1', 'TRPC1', {'sign': -1}), ('CALM1', 'TRPC3', {'sign': -1}), ('CALM1', 'TRPC6', {'sign': -1}), ('CALM1', 'TRPV1', {'sign': -1}), ('CALM1', 'TRPV4', {'sign': -1}), ('CALM1', 'TRPV5', {'sign': -1}), ('CALM1', 'TRPV6', {'sign': -1}), ('CALM1', 'DAPK1', {'sign': -1}), ('CALM1', 'MYLK', {'sign': -1}), ('CALM1', 'MYLK2', {'sign': -1}), ('CALM1', 'CAMK2A', {'sign': -1}), ('CALM1', 'IQGAP1', {'sign': -1}), ('CALM1', 'ATP2B1', {'sign': -1}), ('CALM1', 'NOS1', {'sign': -1}), ('CALM1', 'CAMK4', {'sign': -1}), ('CALM1', 'ADCY1', {'sign': -1}), ('CALM1', 'EEF2K', {'sign': -1}), ('CALM1', 'CAMKK2', 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{'sign': -1}), ('ABL1', 'MUC1', {'sign': -1}), ('ABL1', 'MYOD1', {'sign': -1}), ('ABL1', 'NCK1', {'sign': -1}), ('ABL1', 'HSPA1A', {'sign': -1}), ('ABL1', 'JAK2', {'sign': -1}), ('ABL1', 'JUN', {'sign': -1}), ('ABL1', 'IRS1', {'sign': -1}), ('ABL1', 'MAP3K1', {'sign': -1}), ('ABL1', 'LASP1', {'sign': -1}), ('ABL1', 'MDM2', {'sign': -1}), ('ABL1', 'ERCC3', {'sign': -1}), ('ABL1', 'ERCC6', {'sign': -1}), ('ABL1', 'ESR1', {'sign': -1}), ('ABL1', 'RACK1', {'sign': -1}), ('ABL1', 'GPX1', {'sign': -1}), ('ABL1', 'GRB2', {'sign': -1}), ('ABL1', 'HCLS1', {'sign': -1}), ('ABL1', 'ARHGAP35', {'sign': -1}), ('ABL1', 'ENAH', {'sign': -1}), ('ABL1', 'EGFR', {'sign': -1}), ('ABL1', 'DNM2', {'sign': -1}), ('ABL1', 'DDB2', {'sign': -1}), ('ABL1', 'CTTN', {'sign': -1}), ('ABL1', 'EPHB2', {'sign': -1}), ('ABL1', 'CD19', {'sign': -1}), ('ABL1', 'CBL', {'sign': -1}), ('ABL1', 'CHRNB1', {'sign': -1}), ('ABL1', 'CAV1', {'sign': -1}), ('ABL1', 'CRK', {'sign': -1}), ('ABL1', 'CRKL', {'sign': -1}), ('ABL1', 'CTNNB1', {'sign': -1}), ('ABL1', 'CTNND1', {'sign': -1}), ('ABL1', 'WASF2', {'sign': -1}), ('ABL1', 'WASF3', {'sign': -1}), ('ABL1', 'TRIP10', {'sign': -1}), ('ABL1', 'SYNJ2', {'sign': -1}), ('ABL1', 'TUB', {'sign': -1}), ('ABL1', 'STAT5B', {'sign': -1}), ('ABL1', 'STAT6', {'sign': -1}), ('ABL1', 'STAT5A', {'sign': -1}), ('ABL1', 'STAT3', {'sign': -1}), ('ABL1', 'SOS1', {'sign': -1}), ('ABL1', 'SORBS3', {'sign': -1}), ('ABL1', 'SORBS2', {'sign': -1}), ('ABL1', 'SHC1', {'sign': -1}), ('ABL1', 'ROBO1', {'sign': -1}), ('ABL1', 'RAPH1', {'sign': -1}), ('ABL1', 'RB1', {'sign': -1}), ('ABL1', 'RIN1', {'sign': -1}), ('ABL1', 'RAD52', {'sign': -1}), ('ABL1', 'RAD9A', {'sign': -1}), ('ABL1', 'PXN', {'sign': -1}), ('ABL1', 'RAPGEF1', {'sign': -1}), ('ABL1', 'PTPN6', {'sign': -1}), ('ABL1', 'PSTPIP1', {'sign': -1}), ('ABL1', 'CASP9', {'sign': -1}), ('ABL1', 'CAT', {'sign': -1}), ('ABL1', 'APBB1', {'sign': -1}), ('ABL1', 'APP', {'sign': -1}), ('ABL1', 'BCAR1', {'sign': -1}), ('ABL1', 'BCR', {'sign': -1}), ('ABL1', 'BTK', {'sign': -1}), ('ABL1', 'CDK5', {'sign': -1}), ('ABL1', 'ABL2', {'sign': -1}), ('ABL1', 'ABI1', {'sign': -1}), ('ABL1', 'MTOR', {'sign': -1}), ('ABL1', 'GRAP', {'sign': -1}), ('ABL1', 'VAV1', {'sign': -1}), ('ABL1', 'DOK1', {'sign': -1}), ('ABL1', 'STK4', {'sign': -1}), ('ABL1', 'RBM39', {'sign': -1}), ('ABL1', 'PRKN', {'sign': -1}), ('ABL1', 'TP63', {'sign': -1}), ('ABL1', 'MYLK', {'sign': -1}), ('ABL1', 'ATR', {'sign': -1}), ('ABL1', 'CDKN1B', {'sign': -1}), ('ABL1', 'AHSA1', {'sign': -1}), ('ABL1', 'DDX5', {'sign': -1}), ('ABL1', 'PPARG', {'sign': -1}), ('ABL1', 'UBE3A', {'sign': -1}), ('ABL1', 'CEBPB', {'sign': -1}), ('ABL1', 'SPTLC1', {'sign': -1}), ('ABL1', 'DGCR8', {'sign': -1}), ('ABL1', 'STK3', {'sign': -1}), ('ABL1', 'PLK1', {'sign': -1}), ('ABL1', 'HIPK2', {'sign': -1}), ('ABL1', 'MAP4K1', {'sign': -1}), ('ABL1', 'HDAC2', {'sign': -1}), ('ABL1', 'MET', {'sign': -1}), ('TP73', 'TP53INP1', {'sign': -1}), ('TP73', 'FAS', {'sign': -1}), ('TP73', 'CASP6', {'sign': -1}), ('TP73', 'BBC3', {'sign': -1}), ('TP73', 'CCNB1', {'sign': -1}), ('PRKDC', 'UPF1', {'sign': -1}), ('PRKDC', 'CASP2', {'sign': -1}), ('PRKDC', 'DCLRE1C', {'sign': -1}), ('PRKDC', 'TP53', {'sign': -1}), ('PRKDC', 'TRIM28', {'sign': -1}), ('PRKDC', 'HNRNPU', {'sign': -1}), ('PRKDC', 'H1-1', {'sign': -1}), ('PRKDC', 'EIF2AK4', {'sign': -1}), ('PRKDC', 'MAPK8', {'sign': -1}), ('PRKDC', 'HERC2', {'sign': -1}), ('PRKDC', 'VCP', {'sign': -1}), ('PRKDC', 'WRN', {'sign': -1}), ('PRKDC', 'H2AX', {'sign': -1}), ('PRKDC', 'H1-2', {'sign': -1}), ('PRKDC', 'PDX1', {'sign': -1}), ('PRKDC', 'POU2F1', {'sign': -1}), ('PRKDC', 'GOLPH3', {'sign': -1}), ('PRKDC', 'PNPT1', {'sign': -1}), ('PRKDC', 'PNKP', {'sign': -1}), ('PRKDC', 'RPA2', {'sign': -1}), ('PRKDC', 'IRF3', {'sign': -1}), ('PRKDC', 'CHEK2', {'sign': -1}), ('PRKDC', 'SRF', {'sign': -1}), ('PRKDC', 'AKT1', {'sign': -1}), ('PRKDC', 'LIG4', {'sign': -1}), ('PRKDC', 'FH', {'sign': -1}), ('PRKDC', 'TDP1', {'sign': -1}), ('PRKDC', 'USF1', {'sign': -1}), ('PRKDC', 'MDM2', {'sign': -1}), ('BTRC_CUL1_SKP1', 'PER2', {'sign': -1}), ('BTRC_CUL1_SKP1', 'PER1', {'sign': -1}), ('BTRC_CUL1_SKP1', 'CLSPN', {'sign': -1}), ('BTRC_CUL1_SKP1', 'WEE1', {'sign': -1}), ('BTRC_CUL1_SKP1', 'CDC25A', {'sign': -1}), ('BTRC_CUL1_SKP1', 'FANCM', {'sign': -1}), ('BTRC_CUL1_SKP1', 'FBXO5', {'sign': -1}), ('BTRC_CUL1_SKP1', 'CTNNB1', {'sign': -1}), ('PER2', 'BMAL1', {'sign': -1}), ('PER2', 'NR1D1', {'sign': -1}), ('PER1', 'ATM', {'sign': -1}), ('PER1', 'BMAL1', {'sign': -1}), ('BMAL1', 'CRY2', {'sign': -1}), ('BMAL1', 'CRY1', {'sign': -1}), ('CRY2', 'BMAL1', {'sign': -1}), ('CRY1', 'BMAL1', {'sign': -1}), ('NPAS2', 'PER2', {'sign': -1}), ('NPAS2', 'PER1', {'sign': -1}), ('ATAD2', 'ESR1', {'sign': -1}), ('ATAD2', 'E2F1', {'sign': -1}), ('ATAD2', 'MYC', {'sign': -1}), ('ATAD2', 'AR', {'sign': -1}), ('ESR1', 'WNT4', {'sign': -1}), ('ESR1', 'FOXO1', {'sign': -1}), ('ESR1', 'CXCL12', {'sign': -1}), ('ESR1', 'CRH', {'sign': -1}), ('ESR1', 'GREB1', {'sign': -1}), ('ESR1', 'CCND1', {'sign': -1}), ('ESR1', 'MYC', {'sign': -1}), ('ESR1', 'EBAG9', {'sign': -1}), ('ESR1', 'TFF1', {'sign': -1}), ('ESR1', 'INA', {'sign': -1}), ('ESR1', 'XBP1', {'sign': -1}), ('ESR1', 'FAM102A', {'sign': -1}), ('ESR1', 'KRT8', {'sign': -1}), ('ESR1', 'HSPA8', {'sign': -1}), ('ESR1', 'NME1', {'sign': -1}), ('ESR1', 'HSPD1', {'sign': -1}), ('ESR1', 'SLC2A1', {'sign': -1}), ('ESR1', 'B4GALT1', {'sign': -1}), ('ESR1', 'IGFBP4', {'sign': -1}), ('ESR1', 'TSKU', {'sign': -1}), ('ESR1', 'GATA3', {'sign': -1}), ('ESR1', 'CTSD', {'sign': -1}), ('ESR1', 'RARA', {'sign': -1}), ('ESR1', 'PPARG', {'sign': -1}), ('ESR1', 'RXRA', {'sign': -1}), ('ESR1', 'ESR2', {'sign': -1}), ('ESR1', 'NCOA2', {'sign': -1}), ('ESR1', 'NFE2L2', {'sign': -1}), ('ESR1', 'PIK3R1', {'sign': -1}), ('USP28', 'CLSPN', {'sign': -1}), ('USP28', 'FBXW7', {'sign': -1}), ('USP28', 'MYC', {'sign': -1}), ('USP28', 'SKP1', {'sign': -1}), ('CLSPN', 'DDB2', {'sign': -1}), ('CLSPN', 'UBE2B', {'sign': -1}), ('PRKN', 'CCNE1', {'sign': -1}), ('PRKN', 'SEPTIN5', {'sign': -1}), ('PRKN', 'RANBP2', {'sign': -1}), ('PRKN', 'PUF60', {'sign': -1}), ('PRKN', 'SNCAIP', {'sign': -1}), ('PRKN', 'CTNNB1', {'sign': -1}), ('PRKN', 'JUN', {'sign': -1}), ('PRKN', 'HSPA1B', {'sign': -1}), ('PRKN', 'ATXN2', {'sign': -1}), ('PRKN', 'SNCA', {'sign': -1}), ('PRKN', 'VDAC1', {'sign': -1}), ('PRKN', 'IKBKG', {'sign': -1}), ('PRKN', 'SYT11', {'sign': -1}), ('PRKN', 'GPR37', {'sign': -1}), ('PRKN', 'AIMP2', {'sign': -1}), ('PCNA', 'POLI', {'sign': -1}), ('PCNA', 'POLH', {'sign': -1}), ('PCNA', 'DNMT1', {'sign': -1}), ('PCNA', 'CHAF1B', {'sign': -1}), ('PCNA', 'FANCL', {'sign': -1}), ('PCNA', 'EP300', {'sign': -1}), ('PCNA', 'NEIL1', {'sign': -1}), ('PCNA', 'CDT1', {'sign': -1}), ('PCNA', 'REV3L', {'sign': -1}), ('PCNA', 'RFC1', {'sign': -1}), ('PCNA', 'POLD4', {'sign': -1}), ('PCNA', 'POLE_POLE2_POLE3_POLE4', {'sign': -1}), ('PCNA', 'NCR2', {'sign': -1}), ('POLH', 'REV1', {'sign': -1}), ('MYC', 'JAG2', {'sign': -1}), ('MYC', 'NME1', {'sign': -1}), ('MYC', 'PMAIP1', {'sign': -1}), ('MYC', 'RIOX2', {'sign': -1}), ('MYC', 'MIR17HG', {'sign': -1}), ('MYC', 'CDKN1A', {'sign': -1}), ('MYC', 'PLAC8', {'sign': -1}), ('MYC', 'NFYA', {'sign': -1}), ('MYC', 'NFYC', {'sign': -1}), ('MYC', 'CDKN2A', {'sign': -1}), ('MYC', 'EIF4E', {'sign': -1}), ('MYC', 'CUL1', {'sign': -1}), ('MYC', 'CAPN3', {'sign': -1}), ('MYC', 'TFRC', {'sign': -1}), ('MYC', 'ODC1', {'sign': -1}), ('MYC', 'TFDP1', {'sign': -1}), ('MYC', 'HSPD1', {'sign': -1}), ('MYC', 'EIF4G1', {'sign': -1}), ('MYC', 'EIF4A1', {'sign': -1}), ('MYC', 'BCL2L11', {'sign': -1}), ('MYC', 'TERT', {'sign': -1}), ('MYC', 'CDC25A', {'sign': -1}), ('MYC', 'CCND2', {'sign': -1}), ('MYC', 'CDK4', {'sign': -1}), ('MYC', 'SMAD3', {'sign': -1}), ('MYC', 'SMAD2', {'sign': -1}), ('MYC', 'DNMT3A', {'sign': -1}), ('AR', 'NKX3-1', {'sign': -1}), ('AR', 'FOXO1', {'sign': -1}), ('AR', 'FOXO3', {'sign': -1}), ('AR', 'CFLAR', {'sign': -1}), ('AR', 'CYP3A5', {'sign': -1}), ('AR', 'ANO7', {'sign': -1}), ('AR', 'CASP2', {'sign': -1}), ('AR', 'CDKN1A', {'sign': -1}), ('AR', 'IGFBP3', {'sign': -1}), ('AR', 'F2R', {'sign': -1}), ('AR', 'FKBP5', {'sign': -1}), ('AR', 'FGF8', {'sign': -1}), ('AR', 'MME', {'sign': -1}), ('AR', 'KLK4', {'sign': -1}), ('AR', 'MMP2', {'sign': -1}), ('AR', 'KLK2', {'sign': -1}), ('AR', 'KLK3', {'sign': -1}), ('AR', 'ODC1', {'sign': -1}), ('AR', 'SARG', {'sign': -1}), ('AR', 'ACP3', {'sign': -1}), ('AR', 'CCN5', {'sign': -1}), ('AR', 'SCAP', {'sign': -1}), ('AR', 'STEAP4', {'sign': -1}), ('AR', 'TMPRSS2', {'sign': -1}), ('AR', 'DBI', {'sign': -1}), ('AR', 'MT2A', {'sign': -1}), ('AR', 'PMAIP1', {'sign': -1}), ('AR', 'JUN', {'sign': -1}), ('AR', 'SMS', {'sign': -1}), ('AR', 'SCNN1A', {'sign': -1}), ('AR', 'PFKFB1', {'sign': -1}), ('AR', 'CA3', {'sign': -1}), ('AR', 'KRT18', {'sign': -1}), ('AR', 'DDC', {'sign': -1}), ('AR', 'PGC', {'sign': -1}), ('AR', 'CTNNB1', {'sign': -1}), ('AR', 'NR3C1', {'sign': -1}), ('AR', 'ESR1', {'sign': -1}), ('AR', 'RXRA', {'sign': -1}), ('AR', 'NR5A1', {'sign': -1}), ('AR', 'ERBB3', {'sign': -1}), ('AR', 'EGFR', {'sign': -1}), ('USP7', 'MDM2', {'sign': -1}), ('USP7', 'MDM4', {'sign': -1}), ('USP7', 'FOXO1', {'sign': -1}), ('USP7', 'SKP1', {'sign': -1}), ('USP7', 'MARCHF7', {'sign': -1}), ('USP7', 'CLSPN', {'sign': -1}), ('USP7', 'TP53', {'sign': -1}), ('USP7', 'UBA52', {'sign': -1}), ('USP7', 'CHFR', {'sign': -1}), ('USP7', 'RPS27A', {'sign': -1}), ('MDM4', 'TP53', {'sign': -1}), ('RELA', 'PTEN', {'sign': -1}), ('RELA', 'NCOR2', {'sign': -1}), ('RELA', 'NFKBIA', {'sign': -1}), ('RELA', 'SP1', {'sign': -1}), ('RELA', 'JUN', {'sign': -1}), ('RELA', 'EGR1', {'sign': -1}), ('PTEN', 'E2F1', {'sign': -1}), ('PTEN', 'SP1', {'sign': -1}), ('PTEN', 'PDPK1', {'sign': -1}), ('PTEN', 'AKT3', {'sign': -1}), ('PTEN', 'RAC1', {'sign': -1}), ('PTEN', 'PTK2', {'sign': -1}), ('PTEN', 'CREB1', {'sign': -1}), ('PTEN', 'SHC1', {'sign': -1}), ('RBL2', 'E2F5', {'sign': -1}), ('RBL2', 'E2F4', {'sign': -1}), ('E2F4', 'CLSPN', {'sign': -1}), ('E2F4', 'CDT1', {'sign': -1}), ('E2F4', 'MYBL2', {'sign': -1}), ('E2F4', 'CCNB1', {'sign': -1}), ('E2F4', 'CDK1', {'sign': -1}), ('MDC1', 'TP53BP1', {'sign': -1}), ('MDC1', 'RNF8', {'sign': -1}), ('MDC1', 'NBN', {'sign': -1}), ('TP53BP1', 'HDAC4', {'sign': -1}), ('TP53BP1', 'PAXIP1', {'sign': -1}), ('TP53BP1', 'RIF1', {'sign': -1}), ('TP53BP1', 'TP53', {'sign': -1}), ('H2AX_MDC1', 'RNF8', {'sign': -1}), ('H2AX_MDC1', 'NBN', {'sign': -1}), ('H2AX_MDC1', 'BARD1', {'sign': -1}), ('H2AX_MDC1', 'BLM', {'sign': -1}), ('H2AX_MDC1', 'ACTL6A', {'sign': -1}), ('H2AX_MDC1', 'BRCA1', {'sign': -1}), ('RANBP2', 'TCF7L2', {'sign': -1}), ('RANBP2', 'RANGAP1', {'sign': -1}), ('RANBP2', 'TNPO1', {'sign': -1}), ('PUF60', 'MYC', {'sign': -1}), ('PUF60', 'FUBP1', {'sign': -1}), ('PRKDC_XRCC6', 'XRCC4', {'sign': -1}), ('PRKDC_XRCC6', 'NFKBIA', {'sign': -1}), ('PRKDC_XRCC6', 'TDP1', {'sign': -1}), ('PRKDC_XRCC6', 'LIG4', {'sign': -1}), ('PRKDC_XRCC6', 'DCLRE1C', {'sign': -1}), ('PRKDC_XRCC6', 'H2AX', {'sign': -1}), ('PRKDC_XRCC6', 'AKT2', {'sign': -1}), ('PRKDC_XRCC6', 'AKT1', {'sign': -1}), ('PRKDC_XRCC6', 'TRIM28', {'sign': -1}), ('PRKDC_XRCC6', 'EIF2AK4', {'sign': -1}), ('XRCC4', 'PNKP', {'sign': -1}), ('DCLRE1C', 'XRCC4', {'sign': -1}), ('CTNNB1', 'DAPK2', {'sign': -1}), ('CTNNB1', 'FOXO1', {'sign': -1}), ('CTNNB1', 'FOXO4', {'sign': -1}), ('CTNNB1', 'FOXO3B', {'sign': -1}), ('CTNNB1', 'FOXO3', {'sign': -1}), ('CTNNB1', 'TCF7L2', {'sign': -1}), ('CTNNB1', 'LEF1', {'sign': -1}), ('CTNNB1', 'TCF7', {'sign': -1}), ('CTNNB1', 'PITX2', {'sign': -1}), ('CTNNB1', 'SMAD7', {'sign': -1}), ('CTNNB1', 'TCF4', {'sign': -1}), ('CTNNB1', 'TCF3', {'sign': -1}), ('CTNNB1', 'HNF1A', {'sign': -1}), ('CTNNB1', 'NR4A1', {'sign': -1}), ('CTNNB1', 'NR4A2', {'sign': -1}), ('CTNNB1', 'NR4A3', {'sign': -1}), ('CTNNB1', 'POU5F1', {'sign': -1}), ('CTNNB1', 'PPARG', {'sign': -1}), ('CTNNB1', 'SOX2', {'sign': -1}), ('JUN', 'PPM1D', {'sign': -1}), ('JUN', 'PTGS2', {'sign': -1}), ('JUN', 'NFAT5', {'sign': -1}), ('JUN', 'CTNNB1', {'sign': -1}), ('JUN', 'CGA', {'sign': -1}), ('JUN', 'SMAD4', {'sign': -1}), ('JUN', 'TCF4', {'sign': -1}), ('JUN', 'CREB1', {'sign': -1}), ('JUN', 'SPI1', {'sign': -1}), ('HSPA1B', 'NOD2', {'sign': -1}), ('BACE2', 'APP', {'sign': -1}), ('APP', 'NAE1', {'sign': -1}), ('APP', 'FPR2', {'sign': -1}), ('SNCA', 'VAMP2', {'sign': -1}), ('BACE1', 'APP', {'sign': -1}), ('HDAC4', 'CDKN1A', {'sign': -1}), ('HDAC4', 'MEF2C', {'sign': -1}), ('HDAC4', 'RUNX2', {'sign': -1}), ('HDAC4', 'MEF2D', {'sign': -1}), ('HDAC4', 'MEF2A', {'sign': -1}), ('ADAM17', 'APP', {'sign': -1}), ('ADAM17', 'PTPRF', {'sign': -1}), ('ADAM17', 'HBEGF', {'sign': -1}), ('ADAM17', 'MUC1', {'sign': -1}), ('ADAM17', 'NOTCH1', {'sign': -1}), ('ADAM17', 'TNF', {'sign': -1}), ('ADAM17', 'TGFA', {'sign': -1}), ('ADAM17', 'ITGB1', {'sign': -1}), ('ADAM17', 'ERBB4', {'sign': -1}), ('ADAM17', 'ITGA5', {'sign': -1}), ('ADAM10', 'APP', {'sign': -1}), ('ADAM10', 'NOTCH2', {'sign': -1}), ('ADAM10', 'NOTCH3', {'sign': -1}), ('ADAM10', 'CD44', {'sign': -1}), ('ADAM10', 'NOTCH1', {'sign': -1}), ('ADAM9', 'APP', {'sign': -1}), ('ADAM9', 'ITGAV', {'sign': -1}), ('ADAM9', 'ITGB5', {'sign': -1}), ('ADAM9', 'ITGB1', {'sign': -1}), ('ADAM9', 'ITGA6', {'sign': -1}), ('PREX2', 'PTEN', {'sign': -1}), ('PREX2', 'RAC1', {'sign': -1}), ('PINK1', 'TRAP1', {'sign': -1}), ('PINK1', 'PRKN', {'sign': -1}), ('PINK1', 'CRMP1', {'sign': -1}), ('PINK1', 'BECN1', {'sign': -1}), ('PINK1', 'LETM1', {'sign': -1}), ('PINK1', 'HIF3A', {'sign': -1}), ('PINK1', 'HTRA2', {'sign': -1}), ('PINK1', 'TUFM', {'sign': -1}), ('PINK1', 'RAB8A', {'sign': -1}), ('PINK1', 'UBC', {'sign': -1}), ('PINK1', 'BCL2L1', {'sign': -1}), ('PINK1', 'RHOT1', {'sign': -1}), ('PARK7', 'HTRA2', {'sign': -1}), ('HTRA2', 'BIRC6', {'sign': -1}), ('HTRA2', 'BIRC3', {'sign': -1}), ('HTRA2', 'BIRC2', {'sign': -1}), ('HTRA2', 'XIAP', {'sign': -1}), ('HTRA2', 'PEA15', {'sign': -1}), ('PTPRD', 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-1}), ('PRKCA', 'NOX5', {'sign': -1}), ('PRKCA', 'PDE3A', {'sign': -1}), ('PRKCA', 'EGLN2', {'sign': -1}), ('PRKCA', 'PRKD1', {'sign': -1}), ('PRKCA', 'FERMT3', {'sign': -1}), ('PRKCA', 'ADD2', {'sign': -1}), ('PRKCA', 'LRP1', {'sign': -1}), ('PRKCA', 'PLD2', {'sign': -1}), ('PRKCA', 'HSPB8', {'sign': -1}), ('PRKCA', 'VTN', {'sign': -1}), ('PRKCA', 'GJB1', {'sign': -1}), ('PRKCA', 'CD5', {'sign': -1}), ('PRKCA', 'PRKG1', {'sign': -1}), ('PRKCA', 'FLNC', {'sign': -1}), ('PRKCA', 'CYTH2', {'sign': -1}), ('PRKCA', 'HES1', {'sign': -1}), ('PRKCA', 'TRPV4', {'sign': -1}), ('PRKCA', 'PTPN11', {'sign': -1}), ('PRKCA', 'PEA15', {'sign': -1}), ('PRKCA', 'RALBP1', {'sign': -1}), ('PRKCA', 'SRC', {'sign': -1}), ('PRKCA', 'DLX3', {'sign': -1}), ('PRKCA', 'ADRA1B', {'sign': -1}), ('PRKCA', 'PTPN6', {'sign': -1}), ('PRKCA', 'OCLN', {'sign': -1}), ('PRKCA', 'CDKN2D', {'sign': -1}), ('PRKCA', 'HABP4', {'sign': -1}), ('PRKCA', 'NRGN', {'sign': -1}), ('PRKCA', 'ATP1A1', {'sign': -1}), ('PRKCA', 'GFAP', {'sign': -1}), ('PRKCA', 'PLEK', {'sign': -1}), ('PRKCA', 'SNAP25', {'sign': -1}), ('PRKCA', 'F11R', {'sign': -1}), ('PRKCA', 'ANXA1', {'sign': -1}), ('PRKCA', 'DGKZ', {'sign': -1}), ('PRKCA', 'NCF1', {'sign': -1}), ('PRKCA', 'GPM6A', {'sign': -1}), ('PRKCA', 'CBL', {'sign': -1}), ('PRKCA', 'VIM', {'sign': -1}), ('PRKCA', 'MYL9', {'sign': -1}), ('PRKCA', 'INSR', {'sign': -1}), ('PRKCA', 'KCNJ13', {'sign': -1}), ('PRKCA', 'HRH1', {'sign': -1}), ('PRKCA', 'GJA1', {'sign': -1}), ('PRKCA', 'NPHS1', {'sign': -1}), ('PRKCA', 'TRPM4', {'sign': -1}), ('PRKCA', 'PFKFB2', {'sign': -1}), ('PRKCA', 'PIP5K1B', {'sign': -1}), ('PRKCA', 'NOXA1', {'sign': -1}), ('PRKCA', 'ITPKA', {'sign': -1}), ('PRKCA', 'CDC42EP4', {'sign': -1}), ('PRKCA', 'HNRNPA1', {'sign': -1}), ('PRKCA', 'HMGN2', {'sign': -1}), ('PRKCA', 'CHAT', {'sign': -1}), ('PRKCA', 'PTPN12', {'sign': -1}), ('PRKCA', 'GSK3B', {'sign': -1}), ('PRKCA', 'ITGB4', {'sign': -1}), ('PRKCA', 'TNNI3', {'sign': -1}), ('PRKCA', 'KCNQ2', {'sign': -1}), 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{'sign': -1}), ('PRKCA', 'NR1H4', {'sign': -1}), ('PRKCA', 'EZR', {'sign': -1}), ('PRKCA', 'KCNMA1', {'sign': -1}), ('PRKCA', 'NOXO1', {'sign': -1}), ('PRKCA', 'TP53', {'sign': -1}), ('PRKCA', 'GRIN2B', {'sign': -1}), ('PRKCA', 'CFL1', {'sign': -1}), ('PRKCA', 'THOC5', {'sign': -1}), ('PRKCA', 'CFTR', {'sign': -1}), ('PRKCA', 'ADD3', {'sign': -1}), ('PRKCA', 'PSEN1', {'sign': -1}), ('PRKCA', 'GNAZ', {'sign': -1}), ('PRKCA', 'STXBP1', {'sign': -1}), ('PRKCA', 'GRIA4', {'sign': -1}), ('PRKCA', 'EDF1', {'sign': -1}), ('PRKCA', 'KCNE1', {'sign': -1}), ('PRKCA', 'CREBBP', {'sign': -1}), ('PRKCA', 'ITPKB', {'sign': -1}), ('PRKCA', 'CASR', {'sign': -1}), ('PRKCA', 'DDX5', {'sign': -1}), ('PRKCA', 'CDKN1A', {'sign': -1}), ('PRKCA', 'F3', {'sign': -1}), ('PRKCA', 'MET', {'sign': -1}), ('PRKCA', 'EWSR1', {'sign': -1}), ('PRKCA', 'NFATC1', {'sign': -1}), ('PRKCA', 'GRIN1', {'sign': -1}), ('PRKCA', 'VASP', {'sign': -1}), ('PRKCA', 'FLNA', {'sign': -1}), ('PRKCA', 'RHOA', {'sign': -1}), ('PRKCA', 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{'sign': -1}), ('CDK2', 'HMGA1', {'sign': -1}), ('CDK2', 'UBE2A', {'sign': -1}), ('CDK2', 'RBBP8', {'sign': -1}), ('CDK2', 'RUNX1', {'sign': -1}), ('CDK2', 'ZC3HC1', {'sign': -1}), ('CDK2', 'PRDX1', {'sign': -1}), ('CDK2', 'ESR1', {'sign': -1}), ('CDK2', 'NPM1', {'sign': -1}), ('CDK2', 'COIL', {'sign': -1}), ('CDK2', 'EZH2', {'sign': -1}), ('CDK2', 'PTHLH', {'sign': -1}), ('CDK2', 'LIG1', {'sign': -1}), ('CDK2', 'CDC25C', {'sign': -1}), ('CDK2', 'FOXK2', {'sign': -1}), ('CDK2', 'TK1', {'sign': -1}), ('CDK2', 'MCM4', {'sign': -1}), ('CDK2', 'PRKAR1A', {'sign': -1}), ('CDK2', 'TPX2', {'sign': -1}), ('CDK2', 'SKP2', {'sign': -1}), ('CDK2', 'MCM2', {'sign': -1}), ('CDK2', 'MCM3', {'sign': -1}), ('CDK2', 'SF3B1', {'sign': -1}), ('CDK2', 'CROCC', {'sign': -1}), ('CDK2', 'USP37', {'sign': -1}), ('CDK2', 'ID3', {'sign': -1}), ('CDK2', 'DNMT1', {'sign': -1}), ('CDK2', 'SIRT2', {'sign': -1}), ('CDK2', 'RRN3', {'sign': -1}), ('CDK2', 'ID2', {'sign': -1}), ('CDK2', 'MYOD1', {'sign': -1}), ('CDK2', 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'TGFBR1', {'sign': -1}), ('HSP90AA1', 'NR3C1', {'sign': -1}), ('HSP90AA1', 'AR', {'sign': -1}), ('HSP90AA1', 'NOS3', {'sign': -1}), ('NEO1', 'DAPK1', {'sign': -1}), ('NEO1', 'HJV', {'sign': -1}), ('RRAS', 'RAF1', {'sign': -1}), ('NR3C1', 'AR', {'sign': -1}), ('NR3C1', 'SMAD3', {'sign': -1}), ('NR3C1', 'NR3C2', {'sign': -1}), ('NR3C1', 'PPARG', {'sign': -1}), ('NR3C1', 'NR2F2', {'sign': -1}), ('NR3C1', 'RXRA', {'sign': -1}), ('NR3C1', 'NR4A1', {'sign': -1}), ('NR3C1', 'NR4A2', {'sign': -1}), ('NR3C1', 'NR4A3', {'sign': -1}), ('NR3C1', 'HDAC1', {'sign': -1}), ('NR3C1', 'CEBPB', {'sign': -1}), ('NR3C1', 'LCK', {'sign': -1}), ('NR3C1', 'STAT5A', {'sign': -1}), ('PPP1R14A', 'PPP1CA', {'sign': -1}), ('DAPK2', 'MYL1', {'sign': -1}), ('ROCK1', 'DAPK3', {'sign': -1}), ('ROCK1', 'MYL12A', {'sign': -1}), ('ROCK1', 'LIMK2', {'sign': -1}), ('ROCK1', 'LIMK1', {'sign': -1}), ('ROCK1', 'CDC25A', {'sign': -1}), ('ROCK1', 'MYH10', {'sign': -1}), ('ROCK1', 'PPP1CA', {'sign': -1}), ('ROCK1', 'PFN2', {'sign': -1}), ('ROCK1', 'PPP1R12B', {'sign': -1}), ('ROCK1', 'MYL9', {'sign': -1}), ('ROCK1', 'FHOD1', {'sign': -1}), ('ROCK1', 'GFAP', {'sign': -1}), ('ROCK1', 'ARHGAP24', {'sign': -1}), ('ROCK1', 'RND3', {'sign': -1}), ('ROCK1', 'VIM', {'sign': -1}), ('ROCK1', 'PPP1R12A', {'sign': -1}), ('ROCK1', 'MAPK8IP3', {'sign': -1}), ('ROCK1', 'MYL12B', {'sign': -1}), ('ROCK1', 'RDX', {'sign': -1}), ('ROCK1', 'ARHGAP35', {'sign': -1}), ('ROCK1', 'KCNK3', {'sign': -1}), ('ROCK1', 'EZR', {'sign': -1}), ('ROCK1', 'DES', {'sign': -1}), ('ROCK1', 'ADD1', {'sign': -1}), ('ROCK1', 'PTEN', {'sign': -1}), ('ROCK1', 'SOX9', {'sign': -1}), ('ROCK1', 'DNM1L', {'sign': -1}), ('ROCK1', 'MSN', {'sign': -1}), ('ROCK1', 'PFN1', {'sign': -1}), ('ROCK1', 'PTK2', {'sign': -1}), ('TLN1', 'ITGB1', {'sign': -1}), ('TLN1', 'ITGA2B_ITGB3', {'sign': -1}), ('TLN1', 'ITGB5', {'sign': -1}), ('TLN1', 'ITGB3', {'sign': -1}), ('TLN1', 'ITGB2', {'sign': -1}), ('TLN1', 'ITGB7', {'sign': -1}), ('ITGB1', 'ILK', {'sign': -1}), ('ITGB1', 'PTK2B', {'sign': -1}), ('SMAD4', 'DAPK1', {'sign': -1}), ('SMAD4', 'GNRHR', {'sign': -1}), ('SMAD4', 'IL10', {'sign': -1}), ('SMAD4', 'LEF1', {'sign': -1}), ('SMAD4', 'CREB1', {'sign': -1}), ('SMAD4', 'FOS', {'sign': -1}), ('SMAD4', 'ATF1', {'sign': -1}), ('SMAD4', 'MEF2A', {'sign': -1}), ('SMAD3', 'DAPK1', {'sign': -1}), ('SMAD3', 'GNRHR', {'sign': -1}), ('SMAD3', 'FOXO1', {'sign': -1}), ('SMAD3', 'TCF7L2', {'sign': -1}), ('SMAD3', 'NANOG', {'sign': -1}), ('SMAD3', 'DGCR8', {'sign': -1}), ('SMAD3', 'JUN', {'sign': -1}), ('SMAD3', 'NOTCH1', {'sign': -1}), ('SMAD3', 'AR', {'sign': -1}), ('SMAD3', 'SMAD4', {'sign': -1}), ('SMAD3', 'RUNX2', {'sign': -1}), ('SMAD3', 'ESR1', {'sign': -1}), ('SMAD3', 'LEF1', {'sign': -1}), ('SMAD3', 'MEF2C', {'sign': -1}), ('SMAD3', 'GATA3', {'sign': -1}), ('SMAD3', 'MAX', {'sign': -1}), ('SMAD3', 'MYOD1', {'sign': -1}), ('SMAD3', 'FOXP3', {'sign': -1}), ('SMAD3', 'CEBPB', {'sign': -1}), ('SMAD3', 'PAX8', {'sign': -1}), ('MAP3K4', 'MAP2K6', {'sign': -1}), ('MAP3K4', 'MAP2K4', {'sign': -1}), ('MAP3K4', 'MAP2K3', {'sign': -1}), ('MAP3K1', 'CHUK', {'sign': -1}), ('MAP3K1', 'MAP2K4', {'sign': -1}), ('MAP3K1', 'MAP2K7', {'sign': -1}), ('MAP3K1', 'MAP2K1', {'sign': -1}), ('MAP3K1', 'MAPK3', {'sign': -1}), ('MAP3K1', 'SMAD2', {'sign': -1}), ('MAP3K1', 'MAPK1', {'sign': -1}), ('MAP3K1', 'MAP2K2', {'sign': -1}), ('MAP3K1', 'MAPK8', {'sign': -1}), ('MAP3K1', 'IKBKB', {'sign': -1}), ('MAP3K1', 'FADD', {'sign': -1}), ('MAP3K1', 'STAT3', {'sign': -1}), ('MAP3K1', 'MAP2K6', {'sign': -1}), ('MAP3K1', 'MAP2K3', {'sign': -1}), ('WNT5A', 'FZD2', {'sign': -1}), ('WNT5A', 'FZD5', {'sign': -1}), ('WNT5A', 'ROR2', {'sign': -1}), ('WNT5A', 'FZD1', {'sign': -1}), ('WNT5A', 'FZD4', {'sign': -1}), ('WNT5A', 'ROR1', {'sign': -1}), ('WNT5A', 'NLK', {'sign': -1}), ('WNT5A', 'FZD6', {'sign': -1}), ('WNT5A', 'FZD3', {'sign': -1}), ('WNT5A', 'LRP6', {'sign': -1}), ('WNT5A', 'RYK', {'sign': -1}), ('WNT5A', 'FZD8', {'sign': -1}), ('WNT5A', 'FZD7', {'sign': -1}), ('SP1', 'WNT5A', {'sign': -1}), ('SP1', 'GDF15', {'sign': -1}), ('SP1', 'BNIP3L', {'sign': -1}), ('SP1', 'HDAC4', {'sign': -1}), ('SP1', 'CDKN1A', {'sign': -1}), ('SP1', 'POLK', {'sign': -1}), ('SP1', 'TBX21', {'sign': -1}), ('SP1', 'PKD1', {'sign': -1}), ('SP1', 'SLC47A1', {'sign': -1}), ('SP1', 'SLU7', {'sign': -1}), ('SP1', 'GCNT1', {'sign': -1}), ('SP1', 'LHX4', {'sign': -1}), ('SP1', 'MDC1', {'sign': -1}), ('SP1', 'KLF8', {'sign': -1}), ('SP1', 'PADI3', {'sign': -1}), ('SP1', 'CBS', {'sign': -1}), ('SP1', 'PROS1', {'sign': -1}), ('SP1', 'HAS2', {'sign': -1}), ('SP1', 'LHCGR', {'sign': -1}), ('SP1', 'MGST1', {'sign': -1}), ('SP1', 'CCNB1', {'sign': -1}), ('SP1', 'NOS3', {'sign': -1}), ('SP1', 'DPYD', {'sign': -1}), ('SP1', 'ATP2C1', {'sign': -1}), ('SP1', 'SLC6A3', {'sign': -1}), ('SP1', 'ABCC3', {'sign': -1}), ('SP1', 'SLC22A18', {'sign': -1}), ('SP1', 'PRNP', {'sign': -1}), ('SP1', 'LDHC', {'sign': -1}), ('SP1', 'CCL5', {'sign': -1}), ('SP1', 'VEGFA', {'sign': -1}), ('SP1', 'BIRC5', {'sign': -1}), ('SP1', 'EZR', {'sign': -1}), ('SP1', 'KCTD10', {'sign': -1}), ('SP1', 'COL1A1', {'sign': -1}), ('SP1', 'ADAM17', {'sign': -1}), ('SP1', 'SMARCA1', {'sign': -1}), ('SP1', 'ADGRE5', {'sign': -1}), ('SP1', 'SOD3', {'sign': -1}), ('SP1', 'SREBF1', {'sign': -1}), ('SP1', 'LAT', {'sign': -1}), ('SP1', 'IL10', {'sign': -1}), ('SP1', 'ENTPD1', {'sign': -1}), ('SP1', 'BBC3', {'sign': -1}), ('SP1', 'TAF1A', {'sign': -1}), ('SP1', 'SLC11A1', {'sign': -1}), ('SP1', 'SLC25A1', {'sign': -1}), ('SP1', 'CD2AP', {'sign': -1}), ('SP1', 'IER3', {'sign': -1}), ('APC', 'POLB', {'sign': -1}), ('APC', 'FEN1', {'sign': -1}), ('APC', 'CTNNB1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'DDIT3', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CALR', {'sign': -1}), ('NFYA_NFYB_NFYC', 'HERPUD1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'GADD45A', {'sign': -1}), ('NFYA_NFYB_NFYC', 'TIMP2', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CDC25B', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CCNA2', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CDC25A', {'sign': -1}), ('NFYA_NFYB_NFYC', 'PCNA', {'sign': -1}), ('NFYA_NFYB_NFYC', 'PDGFRB', {'sign': -1}), ('NFYA_NFYB_NFYC', 'PLK1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CCNB1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CDC25C', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CCNB2', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CDK1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'E2F1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'TOP2A', {'sign': -1}), ('NFYA_NFYB_NFYC', 'GHR', {'sign': -1}), ('NFYA_NFYB_NFYC', 'OGG1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'ABCB1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'TARBP2', {'sign': -1}), ('NFYA_NFYB_NFYC', 'PTPN6', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CD34', {'sign': -1}), ('NFYA_NFYB_NFYC', 'ACTB', {'sign': -1}), ('NFYA_NFYB_NFYC', 'HOXB4', {'sign': -1}), ('NFYA_NFYB_NFYC', 'SEPTIN7', {'sign': -1}), ('NFYA_NFYB_NFYC', 'TAX1BP3', {'sign': -1}), ('NFYA_NFYB_NFYC', 'EMX2', {'sign': -1}), ('NFYA_NFYB_NFYC', 'SHOX2', {'sign': -1}), ('NFYA_NFYB_NFYC', 'TIMP3', {'sign': -1}), ('NFYA_NFYB_NFYC', 'BET1', {'sign': -1}), ('NFYA_NFYB_NFYC', 'MTAP', {'sign': -1}), ('NFYA_NFYB_NFYC', 'CDCA3', {'sign': -1}), ('DDIT3', 'BCL2L11', {'sign': -1}), ('DDIT3', 'ITGAM', {'sign': -1}), ('DDIT3', 'FOSL1', {'sign': -1}), ('DDIT3', 'ERO1A', {'sign': -1}), ('DDIT3', 'JUND', {'sign': -1}), ('DDIT3', 'BCL2', {'sign': -1}), ('CALR', 'SCARF1', {'sign': -1}), ('ELAVL1', 'SIRT1', {'sign': -1}), ('ELAVL1', 'FOS', {'sign': -1}), ('ELAVL1', 'MYC', {'sign': -1}), ('ELAVL1', 'CDKN1A', {'sign': -1}), ('ELAVL1', 'CCNA1', {'sign': -1}), ('ELAVL1', 'CCNB1', {'sign': -1}), ('ELAVL1', 'CCNA2', {'sign': -1}), ('ELAVL1', 'TP53', {'sign': -1}), ('ELAVL1', 'IL13', {'sign': -1}), ('ELAVL1', 'DUSP1', {'sign': -1}), ('ELAVL1', 'TRIB3', {'sign': -1}), ('ELAVL1', 'ERBB2', {'sign': -1}), ('ELAVL1', 'CXCL8', {'sign': -1}), ('ELAVL1', 'VEGFA', {'sign': -1}), ('ELAVL1', 'PTGS2', {'sign': -1}), ('ELAVL1', 'BRCA1', {'sign': -1}), ('ELAVL1', 'MDM2', {'sign': -1}), ('ELAVL1', 'EIF4E', {'sign': -1}), ('ELAVL1', 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{'sign': -1}), ('CHEK2', 'TERF2', {'sign': -1}), ('CHEK2', 'PTTG1', {'sign': -1}), ('CHEK2', 'MDM2', {'sign': -1}), ('CHEK2', 'ASF1A', {'sign': -1}), ('CHEK2', 'CDC25C', {'sign': -1}), ('CHEK2', 'BRCA1', {'sign': -1}), ('CHEK2', 'E2F1', {'sign': -1}), ('CHEK2', 'SOD1', {'sign': -1}), ('CHEK2', 'FOXM1', {'sign': -1}), ('CHEK2', 'MAPT', {'sign': -1}), ('CHEK2', 'BECN1', {'sign': -1}), ('CHEK2', 'AATF', {'sign': -1}), ('CHEK2', 'MDM4', {'sign': -1}), ('CHEK2', 'RB1', {'sign': -1}), ('CHEK2', 'VHL', {'sign': -1}), ('CHEK2', 'XRCC1', {'sign': -1}), ('CHEK2', 'RASGRF1', {'sign': -1}), ('CHEK2', 'PPP2R5C', {'sign': -1}), ('CHEK1', 'WEE1', {'sign': -1}), ('CHEK1', 'CDC25B', {'sign': -1}), ('CHEK1', 'RAD51', {'sign': -1}), ('CHEK1', 'TP53', {'sign': -1}), ('CHEK1', 'CDC25A', {'sign': -1}), ('CHEK1', 'UBE2B', {'sign': -1}), ('CHEK1', 'TLK1', {'sign': -1}), ('CHEK1', 'TLK2', {'sign': -1}), ('CHEK1', 'CLSPN', {'sign': -1}), ('CHEK1', 'H3C12', {'sign': -1}), ('CHEK1', 'PTTG1', {'sign': -1}), ('CHEK1', 'CDC25C', {'sign': -1}), ('CHEK1', 'FANCL', {'sign': -1}), ('CHEK1', 'FANCE', {'sign': -1}), ('CHEK1', 'FANCD2', {'sign': -1}), ('CHEK1', 'E2F6', {'sign': -1}), ('CHEK1', 'SYK', {'sign': -1}), ('CHEK1', 'H3-3A', {'sign': -1}), ('CHEK1', 'BLM', {'sign': -1}), ('CHEK1', 'TP73', {'sign': -1}), ('CHEK1', 'RB1', {'sign': -1}), ('CHEK1', 'MDM4', {'sign': -1}), ('CHEK1', 'NEK11', {'sign': -1}), ('CHEK1', 'PABIR1', {'sign': -1}), ('CHEK1', 'NFKB1', {'sign': -1}), ('CHEK1', 'AURKB', {'sign': -1}), ('CHEK1', 'E2F3', {'sign': -1}), ('CHEK1', 'BRCA2', {'sign': -1}), ('WEE1', 'CDK1', {'sign': -1}), ('WEE1', 'CDK2', {'sign': -1}), ('FZD2', 'DVL1', {'sign': -1}), ('CDC25A', 'CDK2', {'sign': -1}), ('CDC25A', 'CDK4', {'sign': -1}), ('CDC25A', 'RAF1', {'sign': -1}), ('CDC25A', 'MAPK3', {'sign': -1}), ('CDC25A', 'CDK6', {'sign': -1}), ('PDGFRB', 'PDGFRA', {'sign': -1}), ('PDGFRB', 'SHC1', {'sign': -1}), ('PDGFRB', 'PLCG1', {'sign': -1}), ('PDGFRB', 'PTPN11', {'sign': -1}), ('PDGFRB', 'NCK1', {'sign': -1}), ('PDGFRB', 'GRAP', {'sign': -1}), ('PDGFRB', 'RASA1', {'sign': -1}), ('PDGFRB', 'CRK', {'sign': -1}), ('PDGFRB', 'NCK2', {'sign': -1}), ('PDGFRB', 'FYN', {'sign': -1}), ('PDGFRB', 'PTK2', {'sign': -1}), ('PDGFRB', 'GRB2', {'sign': -1}), ('PDGFRB', 'SRC', {'sign': -1}), ('PDGFRB', 'PIK3R1', {'sign': -1}), ('PDGFRB', 'GAB1', {'sign': -1}), ('PLK1', 'WEE1', {'sign': -1}), ('PLK1', 'FBXO5', {'sign': -1}), ('PLK1', 'PKMYT1', {'sign': -1}), ('PLK1', 'STAG2', {'sign': -1}), ('PLK1', 'RAD21', {'sign': -1}), ('PLK1', 'FANCM', {'sign': -1}), ('PLK1', 'EVI5', {'sign': -1}), ('PLK1', 'SMC1A', {'sign': -1}), ('PLK1', 'CLSPN', {'sign': -1}), ('PLK1', 'CDC25C', {'sign': -1}), ('PLK1', 'BORA', {'sign': -1}), ('PLK1', 'BUB1B', {'sign': -1}), ('PLK1', 'ECT2', {'sign': -1}), ('PLK1', 'CCNB1', {'sign': -1}), ('PLK1', 'CHEK2', {'sign': -1}), ('PLK1', 'TP53BP1', {'sign': -1}), ('PLK1', 'G6PD', {'sign': -1}), ('PLK1', 'RACGAP1', {'sign': -1}), ('PLK1', 'BRCA2', {'sign': -1}), ('PLK1', 'TOP2A', 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{'sign': -1}), ('PPP3CA_PPP3R1', 'BAD', {'sign': -1}), ('PPP3CA_PPP3R1', 'NFATC2', {'sign': -1}), ('PPP3CA_PPP3R1', 'NFATC1', {'sign': -1}), ('BMPR2', 'ACVR1', {'sign': -1}), ('BMPR2', 'BMPR1B', {'sign': -1}), ('BMPR2', 'BMPR1A', {'sign': -1}), ('LEF1', 'FAIM2', {'sign': -1}), ('LEF1', 'TLE1', {'sign': -1}), ('LEF1', 'MITF', {'sign': -1}), ('LEF1', 'ALX4', {'sign': -1}), ('FAIM2', 'BAX', {'sign': -1}), ('PPARG', 'KMT5A', {'sign': -1}), ('PPARG', 'CD36', {'sign': -1}), ('PPARG', 'FABP4', {'sign': -1}), ('PPARG', 'KLF15', {'sign': -1}), ('PPARG', 'ADIPOQ', {'sign': -1}), ('PPARG', 'PTGS2', {'sign': -1}), ('PPARG', 'SORBS1', {'sign': -1}), ('PPARG', 'SLC2A4', {'sign': -1}), ('PPARG', 'TBXAS1', {'sign': -1}), ('PPARG', 'NOS2', {'sign': -1}), ('PPARG', 'CDKN1A', {'sign': -1}), ('PPARG', 'GSTA2', {'sign': -1}), ('PPARG', 'NR1H2', {'sign': -1}), ('PPARG', 'NR1H3', {'sign': -1}), ('PPARG', 'RXRG', {'sign': -1}), ('PPARG', 'NR3C1', {'sign': -1}), ('PPARG', 'HDAC1', {'sign': -1}), ('KMT5A', 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{'sign': -1}), ('RB1', 'MYOD1', {'sign': -1}), ('SNCB', 'TP53', {'sign': -1}), ('PRKAB1', 'NOS3', {'sign': -1}), ('PRKAB1', 'ULK1', {'sign': -1}), ('PRKAB1', 'RPTOR', {'sign': -1}), ('PRKAB1', 'FOXO3', {'sign': -1}), ('PRKAB1', 'TSC2', {'sign': -1}), ('FOXO3', 'BCL2L11', {'sign': -1}), ('FOXO3', 'SCP2', {'sign': -1}), ('FOXO3', 'FASLG', {'sign': -1}), ('FOXO3', 'CDKN1B', {'sign': -1}), ('FOXO3', 'GADD45A', {'sign': -1}), ('FOXO3', 'PINK1', {'sign': -1}), ('FOXO3', 'ATM', {'sign': -1}), ('FOXO3', 'SOD2', {'sign': -1}), ('FOXO3', 'RBL2', {'sign': -1}), ('FOXO3', 'PIK3CA', {'sign': -1}), ('FOXO3', 'ABCB1', {'sign': -1}), ('FOXO3', 'NOS3', {'sign': -1}), ('FOXO3', 'ID1', {'sign': -1}), ('FOXO3', 'G6PC1', {'sign': -1}), ('FOXO3', 'ESR1', {'sign': -1}), ('FOXO3', 'CDKN2D', {'sign': -1}), ('FOXO3', 'CDKN2B', {'sign': -1}), ('FOXO3', 'DUSP6', {'sign': -1}), ('FOXO3', 'DUSP5', {'sign': -1}), ('FOXO3', 'BNIP3L', {'sign': -1}), ('FOXO3', 'BCL6', {'sign': -1}), ('FOXO3', 'CDKN1A', {'sign': -1}), ('FOXO3', 'CAT', {'sign': -1}), ('FOXO3', 'PRDX3', {'sign': -1}), ('FOXO3', 'TNFSF10', {'sign': -1}), ('FOXO3', 'KLF4', {'sign': -1}), ('PRDM1', 'RASD2', {'sign': -1}), ('NR2F2', 'CEBPA', {'sign': -1}), ('NR2F2', 'PPARG', {'sign': -1}), ('NR2F2', 'RXRA', {'sign': -1}), ('NR2F2', 'NR2F1', {'sign': -1}), ('NR2F2', 'THRA', {'sign': -1}), ('NR2F2', 'NR2F6', {'sign': -1}), ('NR2F2', 'NR3C1', {'sign': -1}), ('NR2F2', 'MYOD1', {'sign': -1}), ('CEBPA', 'SLC11A1', {'sign': -1}), ('CEBPA', 'LTF', {'sign': -1}), ('CEBPA', 'ELANE', {'sign': -1}), ('CEBPA', 'LYZ', {'sign': -1}), ('CEBPA', 'CSF2RA', {'sign': -1}), ('CEBPA', 'MPO', {'sign': -1}), ('CEBPA', 'CD14', {'sign': -1}), ('CEBPA', 'SPI1', {'sign': -1}), ('CEBPA', 'CSF1R', {'sign': -1}), ('CEBPA', 'CSF3R', {'sign': -1}), ('PLK3', 'TP53', {'sign': -1}), ('PLK3', 'TOP2A', {'sign': -1}), ('PLK3', 'CDC25C', {'sign': -1}), ('PLK3', 'HIF1A', {'sign': -1}), ('PLK3', 'PTEN', {'sign': -1}), ('PLK3', 'VRK1', {'sign': -1}), ('PLK3', 'SNCA', {'sign': -1}), ('PLK3', 'ATF2', {'sign': -1}), ('PLK3', 'JUN', {'sign': -1}), ('PLK3', 'SNCB', {'sign': -1}), ('PLK3', 'BCL2L1', {'sign': -1}), ('PLK3', 'CDC25A', {'sign': -1}), ('PLK3', 'CHEK2', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'HDAC4', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'HDAC9', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'MAP3K7', {'sign': -1}), ('HDAC9', 'MEF2C', {'sign': -1}), ('SERPINE1', 'LRP1', {'sign': -1}), ('COP1', 'CASP1', {'sign': -1}), ('COP1', 'NLRC4', {'sign': -1}), ('COP1', 'PYCARD', {'sign': -1}), ('COP1', 'NLRP1', {'sign': -1}), ('COP1', 'CASP5', {'sign': -1}), ('COP1', 'NLRP2', {'sign': -1}), ('COP1', 'CARD8', {'sign': -1}), ('TP63', 'FAS', {'sign': -1}), ('ICAM1', 'ITGAL', {'sign': -1}), ('ICAM1', 'ITGAX', {'sign': -1}), ('ICAM1', 'EGFR', {'sign': -1}), ('ICAM1', 'ITGB2', {'sign': -1}), ('CDKN2B', 'CDK4', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'TP53', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'RB1', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'E2F3', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'H4C2', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'CDKN1A', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'GADD45A', {'sign': -1}), ('MAX_MYC', 'NBN', {'sign': -1}), ('BMP7', 'ACVR2B', {'sign': -1}), ('BMP7', 'BMPR2', {'sign': -1}), ('BMP7', 'ACTR2', {'sign': -1}), ('BMP7', 'ACVR2A', {'sign': -1}), ('BMP7', 'ACVR1', {'sign': -1}), ('BMP7', 'BMPR1A_BMPR1B_BMPR2', {'sign': -1}), ('BMP7', 'ACVR1_BMPR2', {'sign': -1}), ('BMP7', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP7', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP7', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP7', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP7', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP7', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP7', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP7', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP7', 'BMPR1B', {'sign': -1}), ('BMP7', 'BMPR1A', {'sign': -1}), ('PPARA', 'FOXO1', {'sign': -1}), ('PPARA', 'LPL', {'sign': -1}), ('PPARA', 'ELOVL7', {'sign': -1}), ('PPARA', 'CRAT', {'sign': -1}), ('PPARA', 'ACOT1', {'sign': -1}), ('PPARA', 'CIDEC', {'sign': -1}), ('PPARA', 'FABP3', {'sign': -1}), ('PPARA', 'FABP4', {'sign': -1}), ('PPARA', 'ACOX1', {'sign': -1}), ('PPARA', 'NR1H2', {'sign': -1}), ('PPARA', 'RXRG', {'sign': -1}), ('RPS6KA5', 'H2AZ1', {'sign': -1}), ('RPS6KA5', 'RELA', {'sign': -1}), ('RPS6KA5', 'HMGN1', {'sign': -1}), ('RPS6KA5', 'H3C12', {'sign': -1}), ('RPS6KA5', 'CREB1', {'sign': -1}), ('RPS6KA5', 'ATF1', {'sign': -1}), ('RPS6KA5', 'EIF4EBP1', 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-1}), ('CSNK2A1', 'CTNNA1', {'sign': -1}), ('CSNK2A1', 'CORO1C', {'sign': -1}), ('CSNK2A1', 'PRPF3', {'sign': -1}), ('CSNK2A1', 'GPI', {'sign': -1}), ('CSNK2A1', 'CCNF', {'sign': -1}), ('CSNK2A1', 'AMPH', {'sign': -1}), ('CSNK2A1', 'SET', {'sign': -1}), ('CSNK2A1', 'MCM2', {'sign': -1}), ('CSNK2A1', 'PDCD5', {'sign': -1}), ('CSNK2A1', 'PACS1', {'sign': -1}), ('CSNK2A1', 'HES6', {'sign': -1}), ('CSNK2A1', 'F5', {'sign': -1}), ('CSNK2A1', 'CBX1', {'sign': -1}), ('CSNK2A1', 'FUNDC1', {'sign': -1}), ('CSNK2A1', 'BIK', {'sign': -1}), ('MSH2', 'ATR', {'sign': -1}), ('IL1R1_IL1RAP', 'MYD88', {'sign': -1}), ('IL12A', 'IL12RB1', {'sign': -1}), ('IL12A', 'IL12B', {'sign': -1}), ('IL12A', 'IL12RB2', {'sign': -1}), ('DVL2', 'ARRB2', {'sign': -1}), ('DVL2', 'AXIN1', {'sign': -1}), ('DVL2', 'PI4K2B', {'sign': -1}), ('DVL2', 'LRRK2', {'sign': -1}), ('DVL2', 'RAC1', {'sign': -1}), ('DVL2', 'PARD6A', {'sign': -1}), ('TDP2', 'TOP2A', {'sign': -1}), ('TDP2', 'TOP2B', {'sign': -1}), ('CCDC88C', 'DVL1', {'sign': -1}), ('DVL1', 'DAAM1', {'sign': -1}), ('DVL1', 'RAC1', {'sign': -1}), ('DVL1', 'SMAD3', {'sign': -1}), ('DVL1', 'LRRK2', {'sign': -1}), ('DVL1', 'AXIN1', {'sign': -1}), ('DVL1', 'PI4K2B', {'sign': -1}), ('DVL1', 'CTNNB1', {'sign': -1}), ('DVL1', 'JUN', {'sign': -1}), ('DVL1', 'ROCK1', {'sign': -1}), ('DVL1', 'APC', {'sign': -1}), ('DVL1', 'APC_AXIN1_GSK3B', {'sign': -1}), ('DVL1', 'GSK3B', {'sign': -1}), ('PARP2', 'TOP1', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H2AZ1', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H2AX', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'ATM', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H4C2', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'UBTF', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'TP53', {'sign': -1}), ('KAT5', 'AR', {'sign': -1}), ('KAT5', 'MYC', {'sign': -1}), ('KAT5', 'TP53', {'sign': -1}), ('KAT5', 'H3C12', {'sign': -1}), ('KAT5', 'H2AZ1', {'sign': -1}), ('KAT5', 'H4C2', {'sign': -1}), ('KAT5', 'PRKDC', {'sign': -1}), ('KAT5', 'ATM', {'sign': -1}), ('MYCBP', 'MYC', {'sign': -1}), ('MTNR1A', 'GNAQ', {'sign': -1}), ('MTNR1A', 'GNAI3', {'sign': -1}), ('MTNR1A', 'MAPK1', {'sign': -1}), ('MTNR1A', 'GNAI1', {'sign': -1}), ('GNAI3', 'ADCY5', {'sign': -1}), ('GNAI3', 'ADCY6', {'sign': -1}), ('GNAI3', 'ADCY1', {'sign': -1}), ('CDK11A', 'EIF3F', {'sign': -1}), ('CDK11A', 'CDK11B', {'sign': -1}), ('CDK11B', 'EIF3F', {'sign': -1}), ('CUL4A_DDB1_DTL', 'CDKN1A', {'sign': -1}), ('CUL4A_DDB1_DTL', 'CDT1', {'sign': -1}), ('SMARCB1', 'MYC', {'sign': -1}), ('SMARCB1', 'SMARCA4', {'sign': -1}), ('HDAC3', 'TRIM28', {'sign': -1}), ('HDAC3', 'H3C12', {'sign': -1}), ('HDAC3', 'H4C2', {'sign': -1}), ('HDAC3', 'CDKN1A', {'sign': -1}), ('HDAC3', 'RELA', {'sign': -1}), ('HDAC3', 'CREBBP', {'sign': -1}), ('HDAC3', 'MAFK', {'sign': -1}), ('HDAC3', 'HDAC1', {'sign': -1}), ('HDAC3', 'YY1', {'sign': -1}), ('PTTG1', 'TP53', {'sign': -1}), ('PTTG1', 'ESPL1', {'sign': -1}), ('NSMCE2', 'TERF1', {'sign': -1}), ('NSMCE2', 'TERF2IP', {'sign': -1}), ('NSMCE2', 'TERF2', {'sign': -1}), ('NSMCE2', 'TINF2', {'sign': -1}), ('NSMCE2', 'TSNAX', {'sign': -1}), ('NSMCE2', 'SMC6', {'sign': -1}), ('CD28', 'GRB2', {'sign': -1}), ('CD28', 'PIK3R2', {'sign': -1}), ('CD28', 'CBLB', {'sign': -1}), ('CD28', 'PIK3CG', {'sign': -1}), ('CD86', 'CD28', {'sign': -1}), ('CD86', 'CTLA4', {'sign': -1}), ('CD80', 'CD28', {'sign': -1}), ('CD80', 'CTLA4', {'sign': -1}), ('CD80', 'CD274', {'sign': -1}), ('CARD11', 'MALT1', {'sign': -1}), ('BCL10_CARD11_MALT1', 'IKBKB', {'sign': -1}), ('ANXA1', 'FPR2', {'sign': -1}), ('ANXA1', 'FPR3', {'sign': -1}), ('ANXA1', 'FPR1', {'sign': -1}), ('DDX6', 'ALOX15', {'sign': -1}), ('P4HA1_P4HB', 'AGO2', {'sign': -1}), ('AURKA', 'HDAC6', {'sign': -1}), ('AURKA', 'BRCA1', {'sign': -1}), ('AURKA', 'CENPA', {'sign': -1}), ('AURKA', 'CDC25B', {'sign': -1}), ('AURKA', 'PLK1', {'sign': -1}), ('AURKA', 'AJUBA', {'sign': -1}), ('AURKA', 'TACC1', {'sign': -1}), ('AURKA', 'KIF11', {'sign': -1}), ('AURKA', 'CPEB1', {'sign': -1}), ('AURKA', 'PPP1R1B', {'sign': -1}), ('AURKA', 'TPX2', {'sign': -1}), ('AURKA', 'MAP9', {'sign': -1}), ('AURKA', 'NDEL1', {'sign': -1}), ('AURKA', 'RASSF1', {'sign': -1}), ('AURKA', 'TP53', {'sign': -1}), ('AURKA', 'INCENP', {'sign': -1}), ('AURKA', 'WDR62', {'sign': -1}), ('AURKA', 'FADD', {'sign': -1}), ('AURKA', 'DLGAP5', {'sign': -1}), ('AURKA', 'NEDD9', {'sign': -1}), ('AURKA', 'MBD3', {'sign': -1}), ('AURKA', 'H3C12', {'sign': -1}), ('AURKA', 'LATS2', {'sign': -1}), ('AURKA', 'AURKAIP1', {'sign': -1}), ('AURKA', 'PIN1', {'sign': -1}), ('AURKA', 'KIF4A', {'sign': -1}), ('AURKA', 'TACC3', {'sign': -1}), ('AURKA', 'PARD3', {'sign': -1}), ('AURKA', 'FAF1', {'sign': -1}), ('AURKA', 'CETN2', {'sign': -1}), ('AURKA', 'MAPRE3', {'sign': -1}), ('AURKA', 'NFKBIA', {'sign': -1}), ('HDAC6', 'HSP90B1', {'sign': -1}), ('HDAC6', 'CTTN', {'sign': -1}), ('HDAC6', 'TUBA4B', {'sign': -1}), ('HDAC6', 'ELAVL1', {'sign': -1}), ('HDAC6', 'HSP90AA1', {'sign': -1}), ('HSP90B1', 'LRP1', {'sign': -1}), ('PCBP1', 'ALOX15', {'sign': -1}), ('HNRNPK', 'ALOX15', {'sign': -1}), ('HNRNPK', 'TP53', {'sign': -1}), ('HNRNPK', 'MDM2', {'sign': -1}), ('HNRNPK', 'AR', {'sign': -1}), ('HNRNPK', 'CDKN1A', {'sign': -1}), ('HNRNPK', 'MYC', {'sign': -1}), ('HNRNPK', 'SPN', {'sign': -1}), ('HNRNPK', 'EIF4E', {'sign': -1}), ('HNRNPK', 'TK1', {'sign': -1}), ('TRIM8', 'SOCS1', {'sign': -1}), ('MARCHF5', 'RIGI', {'sign': -1}), ('MARCHF5', 'DNM1L', {'sign': -1}), ('MARCHF5', 'FIS1', {'sign': -1}), ('RIGI', 'MAVS', {'sign': -1}), ('RIGI', 'TRAF3', {'sign': -1}), ('RIGI', 'TBK1', {'sign': -1}), ('RIGI', 'IKBKE', {'sign': -1}), ('ZBTB4', 'CDKN1A', {'sign': -1}), ('DDX5', 'TP53', {'sign': -1}), ('DDX5', 'HDAC1', {'sign': -1}), ('DDX5', 'AR', {'sign': -1}), ('DTX3L', 'H4C2', {'sign': -1}), ('NFKBIZ', 'STAT3', {'sign': -1}), ('SP3', 'IL10', {'sign': -1}), ('SP3', 'HAS2', {'sign': -1}), ('ATF1', 'IL10', {'sign': -1}), ('ATF1', 'SH3RF1', {'sign': -1}), ('ATF1', 'CCDC65', {'sign': -1}), ('ATF1', 'NKX6-1', {'sign': -1}), ('ATF1', 'ARNT2', {'sign': -1}), ('ATF1', 'GOLPH3', {'sign': -1}), ('KDM5D', 'H3C12', {'sign': -1}), ('ASH2L_DPY30_HCFC1_HCFC2_KMT2A_KMT2D_MEN1_RBBP5_WDR5_WDR82', 'H3C12', {'sign': -1}), ('ASH2L_DPY30_KDM6A_KMT2B_KMT2C_NCOA6_PAXIP1_RBBP5_WDR5', 'H3C12', {'sign': -1}), ('KDM5B', 'H3C12', {'sign': -1}), ('KDM5B', 'FOXG1', {'sign': -1}), ('KDM5B', 'PAX9', {'sign': -1}), ('KDM5B', 'CBX4', {'sign': -1}), ('KDM5C', 'H3C12', {'sign': -1}), ('ASH1L', 'H3C12', {'sign': -1}), ('KDM5A', 'H3C12', {'sign': -1}), ('PKMYT1', 'CDK1', {'sign': -1}), ('TNFSF14', 'LTBR', {'sign': -1}), ('TNFSF14', 'TNFRSF14', {'sign': -1}), ('TNFSF14', 'TNFRSF6B', {'sign': -1}), ('LTBR', 'MAP3K14', {'sign': -1}), ('LTBR', 'TRAF2', {'sign': -1}), ('CD40LG', 'CD40', {'sign': -1}), ('CD40', 'TRAF2', {'sign': -1}), ('CD40', 'TRAF3', {'sign': -1}), ('TNFSF13B', 'MAP3K14', {'sign': -1}), ('TNFSF13B', 'TNFRSF13C', {'sign': -1}), ('TNFSF13B', 'TNFRSF13B', {'sign': -1}), ('TNFSF13B', 'TNFRSF17', {'sign': -1}), ('LTA', 'TNFRSF1A', {'sign': -1}), ('LTA', 'LTBR', {'sign': -1}), ('LTA', 'TNFRSF14', {'sign': -1}), ('LTA', 'TNFRSF1B', {'sign': -1}), ('LTB', 'LTBR', {'sign': -1}), ('LTB', 'CD40', {'sign': -1}), ('JUNB', 'BCL2', {'sign': -1}), ('JUNB', 'EGFR', {'sign': -1}), ('JUNB', 'BCL2L1', {'sign': -1}), ('KLF4', 'NANOG', {'sign': -1}), ('PIM1', 'BAD', {'sign': -1}), ('PIM1', 'FLT3', {'sign': -1}), ('PIM1', 'RPS19', {'sign': -1}), ('PIM1', 'FOXO3', {'sign': -1}), ('PIM1', 'CDKN1B', {'sign': -1}), ('PIM1', 'MAP3K5', {'sign': -1}), ('PIM1', 'RELA', {'sign': -1}), ('PIM1', 'MARK3', {'sign': -1}), ('PIM1', 'ABCG2', {'sign': -1}), ('PIM1', 'CDKN1A', {'sign': -1}), ('PIM1', 'MDM2', {'sign': -1}), ('PIM1', 'SKP2', {'sign': -1}), ('PIM1', 'H3C12', {'sign': -1}), ('PIM1', 'MYC', {'sign': -1}), ('PIM1', 'NFATC1', {'sign': -1}), ('NRG1', 'ERBB2', {'sign': -1}), ('NRG1', 'ERBB4', {'sign': -1}), ('NRG1', 'ERBB3', {'sign': -1}), ('ERBB3', 'GRB7', {'sign': -1}), ('ERBB3', 'PIK3R1', {'sign': -1}), ('ERBB3', 'GRB2', {'sign': -1}), ('ERBB3', 'PIK3CG', {'sign': -1}), ('ERBB3', 'PIK3CA', {'sign': -1}), ('ERBB3', 'PIK3CD', {'sign': -1}), ('ERBB3', 'PIK3CB', {'sign': -1}), ('GRB7', 'RND1', {'sign': -1}), ('SKP2', 'FOXO1', {'sign': -1}), ('SKP2', 'MYC', {'sign': -1}), ('SKP2', 'CDKN1B', {'sign': -1}), ('SKP2', 'CDKN1A', {'sign': -1}), ('NR1I2', 'FOXO1', {'sign': -1}), ('NR1I2', 'RXRA', {'sign': -1}), ('CXCL8', 'CXCR1', {'sign': -1}), ('CXCL8', 'CXCR2', {'sign': -1}), ('PIAS1', 'CALCOCO1', {'sign': -1}), ('PIAS1', 'SMAD4', {'sign': -1}), ('PIAS1', 'SOX9', {'sign': -1}), ('PIAS1', 'STAT1', {'sign': -1}), ('PIAS1', 'GLI2', {'sign': -1}), ('PIAS1', 'GLI3', {'sign': -1}), ('PIAS1', 'GLI1', {'sign': -1}), ('PIAS1', 'SATB2', {'sign': -1}), ('NDP', 'FZD4', {'sign': -1}), ('FZD4', 'DVL2', {'sign': -1}), ('FZD4', 'DVL1', {'sign': -1}), ('NOLC1', 'CSNK2A1', {'sign': -1}), ('NOLC1', 'TP53', {'sign': -1}), ('AMBRA1_BECN1_PIK3C3_PIK3R4_SH3GLB1_UVRAG', 'MAP1LC3B', {'sign': -1}), ('PRMT5', 'H4C2', {'sign': -1}), ('PRMT5', 'H2AZ1', {'sign': -1}), ('PRMT5', 'H3C12', {'sign': -1}), ('PRMT5', 'HOXA9', {'sign': -1}), ('APC2', 'CTNNB1', {'sign': -1}), ('APC2', 'AXIN1', {'sign': -1}), ('HDAC2', 'H2AZ1', {'sign': -1}), ('HDAC2', 'H2BC11', {'sign': -1}), ('HDAC2', 'H3C12', {'sign': -1}), ('HDAC2', 'H4C2', {'sign': -1}), ('HDAC2', 'STAT3', {'sign': -1}), ('HDAC2', 'YY1', {'sign': -1}), ('HDAC2', 'CCND1', {'sign': -1}), ('HDAC2', 'CIITA', {'sign': -1}), ('CDC73_CTR9_LEO1_PAF1_SKIC8', 'RNF40', {'sign': -1}), ('RNF40', 'RNF20', {'sign': -1}), ('SUV39H1', 'H3C12', {'sign': -1}), ('MTA1', 'SIX3', {'sign': -1}), ('MTA1', 'WNT1', {'sign': -1}), ('MTA1', 'ESR1', {'sign': -1}), ('MTA1', 'BRCA1', {'sign': -1}), ('SIX3', 'WNT1', {'sign': -1}), ('SIAH1', 'CTNNB1', {'sign': -1}), ('SIAH1', 'HIPK2', {'sign': -1}), ('SIAH1', 'NUMB', {'sign': -1}), ('SIAH1', 'SNCAIP', {'sign': -1}), ('USP22', 'H2AZ1', {'sign': -1}), ('USP22', 'H2BC11', {'sign': -1}), ('USP22', 'SIRT1', {'sign': -1}), ('CDX2', 'CDX4', {'sign': -1}), ('KAT2A_SAP130_SUPT3H_SUPT7L_TADA1_TADA2A_TADA3_TAF10_TAF12_TAF5L_TAF6L_TAF9_TRRAP_USP22', 'H2BC11', {'sign': -1}), ('KAT2A_SAP130_SUPT3H_SUPT7L_TADA1_TADA2A_TADA3_TAF10_TAF12_TAF5L_TAF6L_TAF9_TRRAP_USP22', 'H3C12', {'sign': -1}), ('RNF8_UBE2N', 'H2AZ1', {'sign': -1}), ('RNF8_UBE2N', 'H2AX', {'sign': -1}), ('CSNK1E', 'CTNND1', {'sign': -1}), ('CSNK1E', 'CDH1', {'sign': -1}), ('CSNK1E', 'DVL1', {'sign': -1}), ('CSNK1E', 'PER2', {'sign': -1}), ('CSNK1E', 'CDC25A', {'sign': -1}), ('CSNK1E', 'AXIN1', {'sign': -1}), ('CSNK1E', 'SMO', {'sign': -1}), ('CSNK1E', 'LRP6', {'sign': -1}), ('CSNK1E', 'ROR2', {'sign': -1}), ('CSNK1E', 'PER3', {'sign': -1}), ('CSNK1E', 'EIF4EBP1', {'sign': -1}), ('CSNK1E', 'PER1', {'sign': -1}), ('CSNK1E', 'BID', {'sign': -1}), ('CSNK1E', 'APC', {'sign': -1}), ('CSNK1E', 'DVL2', {'sign': -1}), ('CSNK1E', 'YAP1', {'sign': -1}), ('CSNK1E', 'WWTR1', {'sign': -1}), ('CSNK1E', 'CTNNB1', {'sign': -1}), ('CSNK1E', 'TP53', {'sign': -1}), ('CSNK1E', 'YWHAQ', {'sign': -1}), ('CTNND1', 'CDH1', {'sign': -1}), ('CTNND1', 'CDH3', {'sign': -1}), ('CTNND1', 'CDH2', {'sign': -1}), ('CTNND1', 'CDH5', {'sign': -1}), ('UBE2N', 'TRAF2', {'sign': -1}), ('UBE2N', 'TRAF6', {'sign': -1}), ('UBE2N', 'PCNA', {'sign': -1}), ('UBE2N', 'H2AX', {'sign': -1}), ('UBE2N', 'UBE2V1', {'sign': -1}), ('UBE2N', 'MAP3K7', {'sign': -1}), ('SENP2', 'TCF7L2', {'sign': -1}), ('SMURF2', 'PRICKLE1', {'sign': -1}), ('SMURF2', 'TGFBR1', {'sign': -1}), ('SMURF2', 'SMAD2', {'sign': -1}), ('SMURF2', 'SMAD1', 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'HSF1', {'sign': -1}), ('CAMK2A', 'RYR2', {'sign': -1}), ('CAMK2A', 'ADCY3', {'sign': -1}), ('RNF111', 'SKI', {'sign': -1}), ('RNF111', 'SMAD7', {'sign': -1}), ('RNF111', 'SKIL', {'sign': -1}), ('RNF111', 'SMAD3', {'sign': -1}), ('RNF111', 'SMAD2', {'sign': -1}), ('SKI', 'SMAD3', {'sign': -1}), ('SKI', 'SMAD2', {'sign': -1}), ('SKI', 'SMAD4', {'sign': -1}), ('SKI', 'EP300', {'sign': -1}), ('SMAD7', 'SMURF2', {'sign': -1}), ('SMAD7', 'TGFBR1', {'sign': -1}), ('SMAD7', 'SMAD3', {'sign': -1}), ('SMAD7', 'SMAD2', {'sign': -1}), ('SMAD7', 'BMPR1A', {'sign': -1}), ('SMAD7', 'ACVR1', {'sign': -1}), ('SMAD7', 'ACVRL1', {'sign': -1}), ('SMAD7', 'BMPR1B', {'sign': -1}), ('SMAD7', 'TAB1', {'sign': -1}), ('SMAD7', 'PPP1R15A', {'sign': -1}), ('SMAD7', 'PPP1CA', {'sign': -1}), ('SMAD7', 'TAB2', {'sign': -1}), ('SMAD7', 'STRAP', {'sign': -1}), ('SMAD7', 'TAB3', {'sign': -1}), ('BUB1', 'CDC20', {'sign': -1}), ('BUB1', 'SMC1A', {'sign': -1}), ('BUB1', 'PLK1', {'sign': -1}), ('BUB1', 'BUB3', {'sign': -1}), ('BUB1', 'H2AC15', {'sign': -1}), ('SKIL', 'SMAD2', {'sign': -1}), ('SKIL', 'SMAD3', {'sign': -1}), ('SKIL', 'SMAD4', {'sign': -1}), ('SKIL', 'SMAD1', {'sign': -1}), ('KIF4A', 'PRC1', {'sign': -1}), ('KDM1B', 'H3C12', {'sign': -1}), ('TTK', 'PRC1', {'sign': -1}), ('TTK', 'TACC2', {'sign': -1}), ('TTK', 'CDCA8', {'sign': -1}), ('TTK', 'ABL1', {'sign': -1}), ('TTK', 'CHEK2', {'sign': -1}), ('TTK', 'TP53', {'sign': -1}), ('TTK', 'HSPA9', {'sign': -1}), ('TTK', 'MAD1L1', {'sign': -1}), ('ESPL1', 'SMC1A', {'sign': -1}), ('ACTB', 'PLD1', {'sign': -1}), ('ACTB', 'CFL1', {'sign': -1}), ('ACTB', 'ARPC2', {'sign': -1}), ('ACTB', 'CTTN', {'sign': -1}), ('NR4A1', 'BCL2', {'sign': -1}), ('NR4A1', 'NR2F2', {'sign': -1}), ('NR4A1', 'NR2F1', {'sign': -1}), ('NR4A1', 'NR4A2', {'sign': -1}), ('NR4A1', 'NR4A3', {'sign': -1}), ('GADD45GIP1', 'NR4A1', {'sign': -1}), ('GADD45GIP1', 'NFE2L2', {'sign': -1}), ('USP9X', 'MARCHF7', {'sign': -1}), ('USP9X', 'SMAD4', {'sign': -1}), ('TOLLIP', 'IRAK1', {'sign': -1}), ('TGFBR1', 'SHC1', {'sign': -1}), ('TGFBR1', 'ENG', {'sign': -1}), ('TGFBR1', 'PPP2R2A', {'sign': -1}), ('TGFBR1', 'FNTA', {'sign': -1}), ('TGFBR1', 'SMAD3', {'sign': -1}), ('TGFBR1', 'SMAD2', {'sign': -1}), ('TGFBR1', 'PIK3R1', {'sign': -1}), ('TGFBR1', 'VPS39', {'sign': -1}), ('TGFBR1', 'PARD6A', {'sign': -1}), ('TGFBR1', 'ACVRL1', {'sign': -1}), ('TGFBR1', 'EIF3I', {'sign': -1}), ('TGFBR1', 'CDC42', {'sign': -1}), ('TGFBR1', 'TRAF6', {'sign': -1}), ('TGFBR1', 'RHOA', {'sign': -1}), ('TGFBR1', 'EEF1A1', {'sign': -1}), ('TGFBR1', 'PIK3R2', {'sign': -1}), ('TGFBR1', 'TGFBR3', {'sign': -1}), ('TGFBR1', 'SMAD1', {'sign': -1}), ('GMNN', 'CDC6', {'sign': -1}), ('GMNN', 'CDT1', {'sign': -1}), ('MAP2K5', 'MAPK7', {'sign': -1}), ('ING2', 'EP300', {'sign': -1}), ('ING2', 'HDAC1', {'sign': -1}), ('PTH', 'PTH2R', {'sign': -1}), ('PTH', 'PTH1R', {'sign': -1}), ('CUL1_RBX1_SKP1_SKP2', 'CDT1', {'sign': -1}), ('CUL1_RBX1_SKP1_SKP2', 'CDKN1A', {'sign': -1}), ('CCNH', 'CDK7', {'sign': -1}), ('BRCA2', 'RAD51', {'sign': -1}), ('BRCA2', 'POLH', {'sign': -1}), ('CENPE', 'BUB1B', {'sign': -1}), ('CDCA8_PRC1', 'CENPE', {'sign': -1}), ('CLK2', 'ATR', {'sign': -1}), ('CLK2', 'PTPN1', {'sign': -1}), ('GFI1B', 'CDKN1A', {'sign': -1}), ('BTF3', 'GAL', {'sign': -1}), ('BTF3', 'EPHB2', {'sign': -1}), ('GAL', 'GALR1', {'sign': -1}), ('GAL', 'GALR2', {'sign': -1}), ('GAL', 'GALR3', {'sign': -1}), ('EPHB2', 'SRC', {'sign': -1}), ('EPHB2', 'RASA1', {'sign': -1}), ('EPHB2', 'SYNJ1', {'sign': -1}), ('EPHB2', 'ITSN1', {'sign': -1}), ('EPHB2', 'RRAS', {'sign': -1}), ('EPHB2', 'NRCAM', {'sign': -1}), ('EPHB2', 'ARHGEF15', {'sign': -1}), ('RNF20_RNF40_UBE2E1', 'H2BC11', {'sign': -1}), ('RNF20_RNF40_UBE2E1', 'H2BC3', {'sign': -1}), ('NEDD4', 'POLR2L', {'sign': -1}), ('NEDD4', 'IGF1R', {'sign': -1}), ('NEDD4', 'PTEN', {'sign': -1}), ('ERCC8', 'HMGN1', {'sign': -1}), ('ERCC8', 'TCEA2', {'sign': -1}), ('ERCC8', 'XAB2', {'sign': -1}), ('ERCC8', 'XPA', {'sign': -1}), ('ERCC8', 'ERCC6', {'sign': -1}), ('MAD2L2', 'CDC20', {'sign': -1}), ('MAD2L2', 'CDH1', {'sign': -1}), ('MAD2L2', 'MAPK10', {'sign': -1}), ('MAD2L2', 'FZR1', {'sign': -1}), ('HLTF', 'PCNA', {'sign': -1}), ('SHPRH', 'PCNA', {'sign': -1}), ('SHPRH', 'UBE2V2', {'sign': -1}), ('TGFBR2', 'EIF3I', {'sign': -1}), ('TGFBR2', 'TGFBR1', {'sign': -1}), ('TGFBR2', 'TGFBR3', {'sign': -1}), ('TGFBR2', 'PARD6A', {'sign': -1}), ('TGFBR2', 'ENG', {'sign': -1}), ('TGFBR2', 'SMAD2', {'sign': -1}), ('TGFBR2', 'SMAD3', {'sign': -1}), ('TGFBR2', 'PIK3R1', {'sign': -1}), ('TGFBR2', 'ZFYVE9', {'sign': -1}), ('TGFBR2', 'VPS39', {'sign': -1}), ('TGFBR2', 'TRAF6', {'sign': -1}), ('TGFBR2', 'MAP3K7', {'sign': -1}), ('TGFBR2', 'PIK3CA_PIK3R1', {'sign': -1}), ('TGFBR2', 'PIK3R2', {'sign': -1}), ('CSNK1G2', 'SMAD3', {'sign': -1}), ('CSNK1G2', 'PER1', {'sign': -1}), ('CSNK1G2', 'CERT1', {'sign': -1}), ('CSNK1G2', 'TP53', {'sign': -1}), ('CSNK1G2', 'YWHAQ', {'sign': -1}), ('PARD6A', 'SMURF1', {'sign': -1}), ('PPP2R2A', 'RAF1', {'sign': -1}), ('PPP2R2A', 'KSR1', {'sign': -1}), ('PPP2R2A', 'AKT1', {'sign': -1}), ('PPP2R2A', 'PPP2CA', {'sign': -1}), ('PJA1', 'SPTBN1', {'sign': -1}), ('PJA1', 'EZH2', {'sign': -1}), ('FNTA', 'KRAS', {'sign': -1}), ('FNTA', 'HRAS', {'sign': -1}), ('MEF2C', 'JUN', {'sign': -1}), ('MEF2C', 'MYOD1', {'sign': -1}), ('NEDD4L', 'SMAD2', {'sign': -1}), ('NEDD4L', 'SMAD3', {'sign': -1}), ('NEDD4L', 'SMAD7', {'sign': -1}), ('NEDD4L', 'SCNN1A', {'sign': -1}), ('NEDD4L', 'SCN5A', {'sign': -1}), ('FRS2', 'PTPN11', {'sign': -1}), ('FRS2', 'GRB2', {'sign': -1}), ('FRS2', 'GRAP', {'sign': -1}), ('FRS2', 'CBL', {'sign': -1}), ('TNK2', 'MCF2', {'sign': -1}), ('TNK2', 'SNX9', {'sign': -1}), ('TNK2', 'AKT1', {'sign': -1}), ('TNK2', 'AR', {'sign': -1}), ('TNK2', 'BCAR1', {'sign': -1}), ('MCF2', 'RHOA', {'sign': -1}), ('MCF2', 'CDC42', {'sign': -1}), ('KSR1', 'RAF1', {'sign': -1}), ('PTK6', 'KHDRBS1', {'sign': -1}), ('PTK6', 'STAP2', {'sign': -1}), ('PTK6', 'STAT3', {'sign': -1}), ('PTK6', 'BCAR1', {'sign': -1}), ('PTK6', 'AKT1', {'sign': -1}), ('PTK6', 'ARHGAP5', {'sign': -1}), ('PTK6', 'EPS8', {'sign': -1}), ('PTK6', 'ARAP1', {'sign': -1}), ('PTK6', 'STAT5B', {'sign': -1}), ('PTK6', 'PXN', {'sign': -1}), ('PTK6', 'ARHGAP35', {'sign': -1}), ('KHDRBS1', 'CREBBP', {'sign': -1}), ('PIAS2', 'SMAD4', {'sign': -1}), ('PIAS2', 'STAT4', {'sign': -1}), ('VAV2', 'RAC1', {'sign': -1}), ('VAV2', 'ARHGAP1', {'sign': -1}), ('VAV2', 'CDC42', {'sign': -1}), ('VAV2', 'RHOA', {'sign': -1}), ('CRK', 'CBL', {'sign': -1}), ('CRK', 'RAPGEF1', {'sign': -1}), ('CRK', 'NEDD9', {'sign': -1}), ('CRK', 'MAP4K1', {'sign': -1}), ('CRK', 'MAPK8', {'sign': -1}), ('CRK', 'PXN', {'sign': -1}), ('CRK', 'MAP4K5', {'sign': -1}), ('CRK', 'PTK2', {'sign': -1}), ('CRK', 'GAB1', {'sign': -1}), ('CRK', 'DOCK1', {'sign': -1}), ('PTPN5', 'FYN', {'sign': -1}), ('PTPN5', 'BAK1', {'sign': -1}), ('PTPN5', 'MAPK14', {'sign': -1}), ('PTPN11', 'EGFR', {'sign': -1}), ('PTPN11', 'PXN', {'sign': -1}), ('PTPN11', 'TERT', {'sign': -1}), ('PTPN11', 'PTK2B', {'sign': -1}), ('PTPN11', 'STAT5B', {'sign': -1}), ('PTPN11', 'GAB2', {'sign': -1}), ('PTPN11', 'CSF2RB', {'sign': -1}), ('PTPN11', 'STAT5A', {'sign': -1}), ('PTPN11', 'STAT3', {'sign': -1}), ('PTPN11', 'PIK3R2', {'sign': -1}), ('PTPN11', 'IRS1', {'sign': -1}), ('PTPN11', 'SIRPA', {'sign': -1}), ('PTPN11', 'GRB2', {'sign': -1}), ('PTPN11', 'PIK3R1', {'sign': -1}), ('PTPN11', 'GAB1', {'sign': -1}), ('PTPN11', 'STAT1', {'sign': -1}), ('PTPN11', 'JAK3', {'sign': -1}), ('PTPN11', 'IGF1R', {'sign': -1}), ('PTPN11', 'SPRY1', {'sign': -1}), ('PTPN11', 'PIK3CA', {'sign': -1}), ('PTPN11', 'HRAS', {'sign': -1}), ('PTPN11', 'PTK2', {'sign': -1}), ('PTPN11', 'CTNNA1', {'sign': -1}), ('PTPN11', 'MAP3K5', {'sign': -1}), ('PTPN11', 'KRAS', {'sign': -1}), ('PTPN11', 'ERBB2', {'sign': -1}), ('PTPN11', 'SRC', {'sign': -1}), ('PTPN11', 'NRAS', {'sign': -1}), ('PTPN11', 'MPZL1', {'sign': -1}), ('PTPN11', 'VAV2', {'sign': -1}), ('PTPN11', 'VAV3', {'sign': -1}), ('PTPN11', 'PAG1', {'sign': -1}), ('PTPN11', 'MAP3K4', {'sign': -1}), ('PTPN11', 'KDR', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'APEX1', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'MUTYH', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'TOPBP1', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'POLB', {'sign': -1}), ('ECT2', 'CDC42', {'sign': -1}), ('ECT2', 'RHOA', {'sign': -1}), ('RACGAP1', 'CDC42', {'sign': -1}), ('DIAPH3', 'CENPA', {'sign': -1}), ('TPX2', 'CDCA8', {'sign': -1}), ('NUSAP1', 'CDCA8', {'sign': -1}), ('PLCG2', 'CDKN1A', {'sign': -1}), ('PPP3R1', 'NFATC2', {'sign': -1}), ('PPP3R1', 'NFATC1', {'sign': -1}), ('PPP3R1', 'PPP1R1B', {'sign': -1}), ('PPP3R1', 'GABRA1', {'sign': -1}), ('PPP3R1', 'MAP2', {'sign': -1}), ('PPP3R1', 'MAPT', {'sign': -1}), ('PPP3R1', 'PPP1R1A', {'sign': -1}), ('PPP3R1', 'BAD', {'sign': -1}), ('PPP3R1', 'CREB1', {'sign': -1}), ('CD19', 'VAV1', {'sign': -1}), ('CD19', 'PIK3CA_PIK3R1', {'sign': -1}), ('CD19', 'PIK3R1', {'sign': -1}), ('PIK3AP1', 'PIK3R1', {'sign': -1}), ('MSL2', 'TP53', {'sign': -1}), ('WSB1', 'HIPK2', {'sign': -1}), ('SIAH2', 'HIPK2', {'sign': -1}), ('SIAH2', 'SNCAIP', {'sign': -1}), ('YAP1', 'TP73', {'sign': -1}), ('YAP1', 'SMAD7', {'sign': -1}), ('YAP1', 'RUNX2', {'sign': -1}), ('YAP1', 'CTNNB1', {'sign': -1}), ('YAP1', 'TEAD3', {'sign': -1}), ('YAP1', 'TEAD1', {'sign': -1}), ('YAP1', 'SMAD1', {'sign': -1}), ('YAP1', 'TEAD4', {'sign': -1}), ('YAP1', 'TEAD2', {'sign': -1}), ('SUV39H2', 'H3C12', {'sign': -1}), ('RAD17', 'RAD9A', {'sign': -1}), ('TP53AIP1', 'CYCS', {'sign': -1}), ('FGFR1', 'FRS2', {'sign': -1}), ('FGFR1', 'GRB14', {'sign': -1}), ('FGFR1', 'PDK1', {'sign': -1}), ('FGFR1', 'BCAR1', {'sign': -1}), ('FGFR1', 'LDHA', {'sign': -1}), ('FGFR1', 'SYNCRIP', {'sign': -1}), ('FGFR1', 'CTTN', {'sign': -1}), ('FGFR1', 'AMOTL2', {'sign': -1}), ('FGFR1', 'ACAT1', {'sign': -1}), ('FGFR1', 'PLCG1', {'sign': -1}), ('BORA', 'AURKA', {'sign': -1}), ('INCENP', 'PLK1', {'sign': -1}), ('INCENP', 'AURKA', {'sign': -1}), ('PTPN2', 'STAT3', {'sign': -1}), ('PTPN2', 'STAT1', {'sign': -1}), ('PTPN2', 'KDR', {'sign': -1}), ('PTPN2', 'JAK1', {'sign': -1}), ('PTPN2', 'STAT5A', {'sign': -1}), ('PTPN2', 'INSR', {'sign': -1}), ('PTPN2', 'JAK3', {'sign': -1}), ('PTPN2', 'GJA1', {'sign': -1}), ('PTPN2', 'SHC1', {'sign': -1}), ('PTPN2', 'MET', {'sign': -1}), ('PTPN2', 'EGFR', {'sign': -1}), ('PTPN2', 'FYN', {'sign': -1}), ('PTPN2', 'SRC', {'sign': -1}), ('PTPN2', 'GHR', {'sign': -1}), ('PTPN2', 'PDGFRB', {'sign': -1}), ('PTPN2', 'STAT6', {'sign': -1}), ('PTPN2', 'WASL', {'sign': -1}), ('PTPN2', 'FKBP4', {'sign': -1}), ('PTPN2', 'STAT5B', {'sign': -1}), ('KDR', 'SHC2', {'sign': -1}), ('KDR', 'ANXA5', {'sign': -1}), ('KDR', 'SHC1', {'sign': -1}), ('KDR', 'GRB2', {'sign': -1}), ('KDR', 'PLCG1', {'sign': -1}), ('KDR', 'PTK2', {'sign': -1}), ('NANOS1', 'HDAC2', {'sign': -1}), ('STAT5A', 'AURKA', {'sign': -1}), ('STAT5A', 'CSN2', {'sign': -1}), ('STAT5A', 'BCL2L1', {'sign': -1}), ('PRKCD', 'PRKDC', {'sign': -1}), ('PRKCD', 'STAT3', {'sign': -1}), ('PRKCD', 'ADCY5', {'sign': -1}), ('PRKCD', 'ELAVL1', {'sign': -1}), ('PRKCD', 'ADCY7', {'sign': -1}), ('PRKCD', 'NCF1', {'sign': -1}), ('PRKCD', 'NFE2L2', {'sign': -1}), ('PRKCD', 'STAT1', {'sign': -1}), ('PRKCD', 'FLI1', {'sign': -1}), ('PRKCD', 'ADRB2', {'sign': -1}), ('PRKCD', 'DNM1L', {'sign': -1}), ('PRKCD', 'G6PD', {'sign': -1}), ('PRKCD', 'PA2G4', {'sign': -1}), ('PRKCD', 'MYBPC3', {'sign': -1}), ('PRKCD', 'PRKD1', {'sign': -1}), ('PRKCD', 'CHN2', {'sign': -1}), ('PRKCD', 'DAB2', {'sign': -1}), ('PRKCD', 'SHC1', {'sign': -1}), ('PRKCD', 'GRM5', {'sign': -1}), ('PRKCD', 'HABP4', {'sign': -1}), ('PRKCD', 'IRS1', {'sign': -1}), ('PRKCD', 'PLSCR3', {'sign': -1}), ('PRKCD', 'GSK3A', {'sign': -1}), ('PRKCD', 'CXCR4', {'sign': -1}), ('PRKCD', 'RPS3', {'sign': -1}), ('PRKCD', 'PPP1R14B', {'sign': -1}), ('PRKCD', 'CHAT', {'sign': -1}), ('PRKCD', 'GRK2', {'sign': -1}), ('PRKCD', 'PEBP1', {'sign': -1}), ('PRKCD', 'BDKRB2', {'sign': -1}), ('PRKCD', 'ADRA2A', {'sign': -1}), ('PRKCD', 'BEST1', {'sign': -1}), ('PRKCD', 'KLF5', {'sign': -1}), ('PRKCD', 'HNRNPK', {'sign': -1}), ('PRKCD', 'SLC29A1', {'sign': -1}), ('PRKCD', 'ITGB7', {'sign': -1}), ('PRKCD', 'TNNI3', {'sign': -1}), ('PRKCD', 'MEP1B', {'sign': -1}), ('PRKCD', 'HMGA1', {'sign': -1}), ('PRKCD', 'C5AR1', {'sign': -1}), ('PRKCD', 'TP73', {'sign': -1}), ('PRKCD', 'NCF4', {'sign': -1}), ('PRKCD', 'TRIM28', {'sign': -1}), ('PRKCD', 'NOS3', {'sign': -1}), ('PRKCD', 'LIMK2', {'sign': -1}), ('PRKCD', 'CDH1', {'sign': -1}), ('PRKCD', 'YWHAZ', {'sign': -1}), ('PRKCD', 'ENOX2', {'sign': -1}), ('PRKCD', 'EGFR', {'sign': -1}), ('PRKCD', 'CAT', {'sign': -1}), ('PRKCD', 'IL6ST', {'sign': -1}), ('PRKCD', 'MUC1', {'sign': -1}), ('PRKCD', 'YWHAB', {'sign': -1}), ('PRKCD', 'PTPRA', {'sign': -1}), ('PRKCD', 'KCNJ1', {'sign': -1}), ('PRKCD', 'ITGB2', {'sign': -1}), ('PRKCD', 'CYBA', {'sign': -1}), ('PRKCD', 'SDC4', {'sign': -1}), ('PRKCD', 'EP300', {'sign': -1}), ('PRKCD', 'MAPK8', {'sign': -1}), ('PRKCD', 'NR2F6', {'sign': -1}), ('PRKCD', 'SMPD1', {'sign': -1}), ('PRKCD', 'FSCN1', {'sign': -1}), ('PRKCD', 'TBL1XR1', {'sign': -1}), ('PRKCD', 'PTPN22', {'sign': -1}), ('PRKCD', 'DAP3', {'sign': -1}), ('PRKCD', 'DBI', {'sign': -1}), ('PRKCD', 'H3C12', {'sign': -1}), ('PRKCD', 'HDAC5', {'sign': -1}), ('PRKCD', 'CTNNB1', {'sign': -1}), ('PRKCD', 'PLD2', {'sign': -1}), ('PRKCD', 'PLSCR1', {'sign': -1}), ('PRKCD', 'TAGLN', {'sign': -1}), ('PRKCD', 'TP53', {'sign': -1}), ('PRKCD', 'KRT8', {'sign': -1}), ('PRKCD', 'BAG3', {'sign': -1}), ('PRKCD', 'CARD9', {'sign': -1}), ('PRKCD', 'MET', {'sign': -1}), ('PRKCD', 'NLRC4', {'sign': -1}), ('DUSP1', 'MAPK14', {'sign': -1}), ('DUSP1', 'FANCI', {'sign': -1}), ('DUSP1', 'MAPK1', {'sign': -1}), ('DUSP1', 'MAPK8', {'sign': -1}), ('DUSP1', 'MAPK3', {'sign': -1}), ('DUSP1', 'MAPK9', {'sign': -1}), ('MAPKAP1_MLST8_MTOR_RICTOR', 'AKT3', {'sign': -1}), ('USF1', 'FOSL1', {'sign': -1}), ('MAPK9', 'CDC25B', {'sign': -1}), ('MAPK9', 'STAT1', {'sign': -1}), ('MAPK9', 'CTNNB1', {'sign': -1}), ('MAPK9', 'MAPK8IP1', 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-1}), ('ACVR2B', 'ACVR1C', {'sign': -1}), ('IFNAR2', 'JAK1', {'sign': -1}), ('IFNAR2', 'TYK2', {'sign': -1}), ('IL21R', 'JAK1', {'sign': -1}), ('IL21R', 'JAK3', {'sign': -1}), ('GH1', 'PRLR', {'sign': -1}), ('GH1', 'GHR', {'sign': -1}), ('IFNGR2', 'JAK1', {'sign': -1}), ('IFNGR2', 'JAK2', {'sign': -1}), ('TSLP', 'CRLF2', {'sign': -1}), ('TSLP', 'IL7R', {'sign': -1}), ('CRLF2', 'JAK2', {'sign': -1}), ('IRF9', 'IFNAR2', {'sign': -1}), ('IFNA13', 'IFNAR1', {'sign': -1}), ('IFNA13', 'IFNAR2', {'sign': -1}), ('IFNA13', 'IFNAR1_IFNAR2', {'sign': -1}), ('IL15', 'IL15RA', {'sign': -1}), ('IL15', 'IL2RG', {'sign': -1}), ('IL15', 'IL2RB', {'sign': -1}), ('IL15RA', 'IL2RB', {'sign': -1}), ('MAP3K11', 'MAP2K4', {'sign': -1}), ('MAP3K11', 'MAP2K3', {'sign': -1}), ('MAP3K11', 'MAP2K6', {'sign': -1}), ('MAP3K11', 'PIN1', {'sign': -1}), ('NRG3', 'ERBB4', {'sign': -1}), ('NRG3', 'EGFR', {'sign': -1}), ('FRZB', 'WNT1', {'sign': -1}), ('FRZB', 'WNT5A', {'sign': -1}), ('FRZB', 'WNT8A', {'sign': -1}), ('IRS4', 'GRAP', {'sign': -1}), ('IRS4', 'PIK3CG', {'sign': -1}), ('MAP3K10', 'MAP2K7', {'sign': -1}), ('MAP3K10', 'MAP2K4', {'sign': -1}), ('MAP3K10', 'DLG4', {'sign': -1}), ('MAP3K10', 'NEUROD1', {'sign': -1}), ('MAP3K10', 'TCF3', {'sign': -1}), ('MAP3K10', 'DYRK2', {'sign': -1}), ('ACVR1', 'SMAD1', {'sign': -1}), ('ACVR1', 'SMAD5', {'sign': -1}), ('ACVRL1', 'SMAD1', {'sign': -1}), ('BMPR1B', 'SMAD5', {'sign': -1}), ('BMPR1B', 'SMAD1', {'sign': -1}), ('BMPR1B', 'SMAD9', {'sign': -1}), ('BMPR1B', 'STAMBP', {'sign': -1}), ('SMAD5', 'SMAD4', {'sign': -1}), ('DUSP8', 'MAPK14', {'sign': -1}), ('DUSP8', 'MAPK8', {'sign': -1}), ('WNT8A', 'FZD7', {'sign': -1}), ('WNT8A', 'FZD8', {'sign': -1}), ('WNT8A', 'LRP5', {'sign': -1}), ('FZD7', 'DVL1', {'sign': -1}), ('AREG', 'EGFR', {'sign': -1}), ('AREG', 'ERBB2', {'sign': -1}), ('HBEGF', 'EGFR', {'sign': -1}), ('HBEGF', 'ERBB4', {'sign': -1}), ('NRG4', 'ERBB4', {'sign': -1}), ('BAMBI', 'BMPR1A', {'sign': -1}), ('BAMBI', 'TGFBR1', {'sign': -1}), ('BAMBI', 'BMPR1B', {'sign': -1}), ('BAMBI', 'ACVRL1', {'sign': -1}), ('BMPR1A', 'SMAD9', {'sign': -1}), ('BMPR1A', 'SMAD1', {'sign': -1}), ('BMPR1A', 'FAM83G', {'sign': -1}), ('BMPR1A', 'BMPR1B', {'sign': -1}), ('MAPK8IP3', 'MAP3K11', {'sign': -1}), ('MAPK8IP3', 'MAP2K7', {'sign': -1}), ('MAPK8IP3', 'MAP2K4', {'sign': -1}), ('MAPK8IP3', 'MAP3K1', {'sign': -1}), ('MAPK8IP3', 'MAPK9', {'sign': -1}), ('OSMR', 'IL6ST', {'sign': -1}), ('OSMR', 'JAK2', {'sign': -1}), ('OSMR', 'JAK1', {'sign': -1}), ('SHOC2', 'KRAS', {'sign': -1}), ('DLL3', 'NOTCH1', {'sign': -1}), ('DLL3', 'NOTCH2', {'sign': -1}), ('DLL3', 'NOTCH3', {'sign': -1}), ('DLL3', 'NOTCH4', {'sign': -1}), ('IL23A', 'IL12RB1', {'sign': -1}), ('IL23A', 'IL23R', {'sign': -1}), ('IL23A', 'IL12RB1_IL23R', {'sign': -1}), ('MAPK12', 'SNTA1', {'sign': -1}), ('MAPK12', 'CARM1', {'sign': -1}), ('MAPK12', 'MAPT', {'sign': -1}), ('MAPK12', 'KRT8', {'sign': -1}), ('MAPK12', 'ATF2', {'sign': -1}), ('MAPK12', 'SH3BP5', {'sign': -1}), ('MAPK12', 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{'sign': -1}), ('NCSTN', 'APH1A', {'sign': -1}), ('NCSTN', 'PSEN2', {'sign': -1}), ('GRB10', 'NEDD4', {'sign': -1}), ('GRB10', 'ABL1', {'sign': -1}), ('IL20RA', 'TYK2', {'sign': -1}), ('IL20RA', 'JAK1', {'sign': -1}), ('IL22RA1', 'TYK2', {'sign': -1}), ('IL22RA1', 'JAK1', {'sign': -1}), ('DISP1', 'SHH', {'sign': -1}), ('APH1A', 'PSEN1', {'sign': -1}), ('APH1A', 'PSEN2', {'sign': -1}), ('APH1A', 'PSENEN', {'sign': -1}), ('LRIG1', 'CBL', {'sign': -1}), ('LRIG1', 'ERBB3', {'sign': -1}), ('LRIG1', 'ERBB2', {'sign': -1}), ('LRIG1', 'ERBB4', {'sign': -1}), ('PPP4C', 'IRS4', {'sign': -1}), ('PPP4C', 'FOXO3', {'sign': -1}), ('PPP4C', 'NDEL1', {'sign': -1}), ('PPP4C', 'BANF1', {'sign': -1}), ('PPP4C', 'HDAC3', {'sign': -1}), ('PPP4C', 'RELA', {'sign': -1}), ('PPP4C', 'H2AX', {'sign': -1}), ('IL31', 'OSMR', {'sign': -1}), ('IL31', 'IL31RA', {'sign': -1}), ('IL31', 'IL31RA_OSMR', {'sign': -1}), ('OSM', 'OSMR', {'sign': -1}), ('OSM', 'LIFR', {'sign': -1}), ('OSM', 'IL6ST', {'sign': -1}), ('OSM', 'IL6ST_OSMR', {'sign': -1}), ('OSM', 'IL6ST_LIFR', {'sign': -1}), ('IL21', 'IL21R', {'sign': -1}), ('IL21', 'IL2RG', {'sign': -1}), ('AMHR2', 'ACVR1', {'sign': -1}), ('AMHR2', 'BMPR1B', {'sign': -1}), ('INHBA', 'ACVR2B', {'sign': -1}), ('INHBA', 'ACTR2', {'sign': -1}), ('INHBA', 'ACVR2A', {'sign': -1}), ('INHBA', 'ACVR1B_ACVR2A', {'sign': -1}), ('INHBA', 'ACVR1B_ACVR2B', {'sign': -1}), ('INHBA', 'ACVR1', {'sign': -1}), ('INHBA', 'BAMBI', {'sign': -1}), ('INHBA', 'ACVR1B', {'sign': -1}), ('BMP6', 'ACVR2B', {'sign': -1}), ('BMP6', 'BMPR2', {'sign': -1}), ('BMP6', 'AMHR2', {'sign': -1}), ('BMP6', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP6', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP6', 'ACVR1_BMPR2', {'sign': -1}), ('BMP6', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP6', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP6', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP6', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP6', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP6', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP6', 'ACVR2A', {'sign': -1}), ('BMP6', 'ACVR1', {'sign': -1}), ('BMP6', 'BMPR1A', {'sign': -1}), ('BMP6', 'BMPR1B', {'sign': -1}), ('GDF6', 'BMPR2', {'sign': -1}), ('GDF6', 'BMPR1A', {'sign': -1}), ('GDF6', 'ACVR2A_BMPR1A', {'sign': -1}), ('GDF6', 'ACVR2B_BMPR1A', {'sign': -1}), ('GDF6', 'BMPR1A_BMPR2', {'sign': -1}), ('GDF6', 'ACVR2A_BMPR1B', {'sign': -1}), ('GDF6', 'ACVR2B_BMPR1B', {'sign': -1}), ('GDF6', 'BMPR1B_BMPR2', {'sign': -1}), ('PPP4R3A', 'PPP4C', {'sign': -1}), ('CDO1', 'SHH', {'sign': -1}), ('IL20', 'IL22RA1', {'sign': -1}), ('IL20', 'IL20RA', {'sign': -1}), ('IL20', 'IL20RB', {'sign': -1}), ('IL20', 'IL20RA_IL20RB', {'sign': -1}), ('IL20', 'IL20RB_IL22RA1', {'sign': -1}), ('IL26', 'IL20RA', {'sign': -1}), ('IL26', 'IL10RB', {'sign': -1}), ('IL19', 'IL20RA', {'sign': -1}), ('IL19', 'IL20RB', {'sign': -1}), ('IL19', 'IL20RA_IL20RB', {'sign': -1}), ('IL27', 'IL27RA', {'sign': -1}), ('GPC3', 'SHH', {'sign': -1}), ('MFAP5', 'NOTCH1', {'sign': -1}), ('DAB1', 'NOTCH1', {'sign': -1}), ('CTF1', 'IL6ST', {'sign': -1}), ('CTF1', 'LIFR', {'sign': -1}), ('CTF1', 'IL6ST_LIFR', {'sign': -1}), ('IL31RA', 'JAK2', {'sign': -1}), ('IL31RA', 'JAK1', {'sign': -1}), ('MTMR4', 'SMAD2', {'sign': -1}), ('MTMR4', 'SMAD3', {'sign': -1}), ('HYAL2', 'SMAD4', {'sign': -1}), ('SIK1', 'SMAD7', {'sign': -1}), ('SIK1', 'CRTC1', {'sign': -1}), ('SIK1', 'CRTC2', {'sign': -1}), ('SIK1', 'CRTC3', {'sign': -1}), ('SIK1', 'TP53', {'sign': -1}), ('PDGFC', 'PDGFRA', {'sign': -1}), ('PDGFC', 'PDGFRB', {'sign': -1}), ('FGF1', 'FGFR1', {'sign': -1}), ('FGF1', 'FGFR2', {'sign': -1}), ('FGF1', 'FGFR4', {'sign': -1}), ('FGF1', 'FGFR3', {'sign': -1}), ('FGFR2', 'GRAP', {'sign': -1}), ('FGFR2', 'FRS2', {'sign': -1}), ('FGFR2', 'GRB2', {'sign': -1}), ('FGFR2', 'PLCG1', {'sign': -1}), ('FGF7', 'FGFR2', {'sign': -1}), ('FGF9', 'FGF10', {'sign': -1}), ('FGF9', 'FGFR3', {'sign': -1}), ('VEGFB', 'FLT1', {'sign': -1}), ('EFNA1', 'EPHA1', {'sign': -1}), ('EFNA1', 'EPHA6', {'sign': -1}), ('EFNA1', 'EPHA8', {'sign': -1}), ('EFNA1', 'EPHA4', {'sign': -1}), ('EFNA1', 'EPHA2', {'sign': -1}), ('EFNA1', 'EPHA3', {'sign': -1}), ('EFNA1', 'EPHA5', {'sign': -1}), ('EFNA1', 'EPHA7', {'sign': -1}), ('EFNA2', 'EPHA2', {'sign': -1}), ('EFNA2', 'EPHA6', {'sign': -1}), ('EFNA2', 'EPHA7', {'sign': -1}), ('EFNA2', 'EPHA8', {'sign': -1}), ('EFNA2', 'EPHA5', {'sign': -1}), ('EFNA2', 'EPHA4', {'sign': -1}), ('EFNA5', 'EPHA5', {'sign': -1}), ('EFNA5', 'EPHA6', {'sign': -1}), ('EFNA5', 'EPHA7', {'sign': -1}), ('EFNA5', 'EPHA4', {'sign': -1}), ('EFNA5', 'EPHA3', {'sign': -1}), ('EFNA5', 'EPHA8', {'sign': -1}), ('EFNA5', 'EPHA2', {'sign': -1}), ('EFNA5', 'EPHB2', {'sign': -1}), ('EFNB3', 'EPHB3', {'sign': -1}), ('EFNB3', 'EPHA4', {'sign': -1}), ('EPHB3', 'RASA1', {'sign': -1}), ('EFNA3', 'EPHA6', {'sign': -1}), ('EFNA3', 'EPHA3', {'sign': -1}), ('EFNA3', 'EPHA7', {'sign': -1}), ('EFNA3', 'EPHA8', {'sign': -1}), ('EFNA3', 'EPHA5', {'sign': -1}), ('EFNA3', 'EPHA2', {'sign': -1}), ('EFNA3', 'EPHA4', {'sign': -1}), ('EFNA3', 'EPHB1', {'sign': -1}), ('EFNA4', 'EPHA6', {'sign': -1}), ('EFNA4', 'EPHA4', {'sign': -1}), ('EFNA4', 'EPHA7', {'sign': -1}), ('EFNA4', 'EPHA8', {'sign': -1}), ('EFNA4', 'EPHA2', {'sign': -1}), ('EFNA4', 'EPHA3', {'sign': -1}), ('EFNA4', 'EPHA5', {'sign': -1}), ('EPHA4', 'NGEF', {'sign': -1}), ('EPHA4', 'ARHGEF15', {'sign': -1}), ('EPHA4', 'FYN', {'sign': -1}), ('EPHA3', 'CRK', {'sign': -1}), ('EPHA3', 'SRC', {'sign': -1}), ('EPHA3', 'FYN', {'sign': -1}), ('EFNB2', 'EPHB4', {'sign': -1}), ('EFNB2', 'EPHB2', {'sign': -1}), ('EFNB2', 'EPHB1', {'sign': -1}), ('EFNB2', 'EPHB3', {'sign': -1}), ('EFNB2', 'EPHA3', {'sign': -1}), ('EFNB2', 'EPHA4', {'sign': -1}), ('NGEF', 'RHOA', {'sign': -1}), ('LTK', 'IRS1', {'sign': -1}), ('LTK', 'PIK3CG', {'sign': -1}), ('LTK', 'CBL', {'sign': -1}), ('LTK', 'SHC1', {'sign': -1}), ('LTK', 'PLCG1', {'sign': -1}), ('LTK', 'RAF1', {'sign': -1}), ('TEK', 'TNIP2', {'sign': -1}), ('TEK', 'DOK2', {'sign': -1}), ('TEK', 'GRAP', {'sign': -1}), ('TEK', 'GRB7', {'sign': -1}), ('TEK', 'GRB14', {'sign': -1}), ('TEK', 'SHC1', {'sign': -1}), ('TEK', 'PIK3R1', {'sign': -1}), ('ANGPT1', 'TEK', {'sign': -1}), ('ANGPT1', 'TIE1', {'sign': -1}), ('ANGPT4', 'TEK', {'sign': -1}), ('ANGPT4', 'TIE1', {'sign': -1}), ('AGRN', 'MUSK', {'sign': -1}), ('AGRN', 'DAG1', {'sign': -1}), ('DOK7', 'MUSK', {'sign': -1}), ('LMTK2', 'PPP1CA', {'sign': -1}), ('GAS6', 'AXL', {'sign': -1}), ('GAS6', 'MERTK', {'sign': -1}), ('GAS6', 'TYRO3', {'sign': -1}), ('AXL', 'TNS2', {'sign': -1}), ('AXL', 'GRAP', {'sign': -1}), ('AXL', 'PIK3CG', {'sign': -1}), ('AXL', 'SOCS1', {'sign': -1}), ('MERTK', 'VAV1', {'sign': -1}), ('TYRO3', 'PIK3R1', {'sign': -1}), ('GDNF', 'RET', {'sign': -1}), ('GDNF', 'GFRA2', {'sign': -1}), ('GDNF', 'NCAM1', {'sign': -1}), ('GDNF', 'GFRA1', {'sign': -1}), ('NR0B1', 'ESR1', {'sign': -1}), ('NR0B1', 'NR5A1', {'sign': -1}), ('NR0B1', 'AR', {'sign': -1}), ('NR0B1', 'ESR2', {'sign': -1}), ('NR0B1', 'NR5A2', {'sign': -1}), ('NR0B1', 'ESRRG', {'sign': -1}), ('NR0B1', 'ESRRB', {'sign': -1}), ('NR0B1', 'PGR', {'sign': -1}), ('NR0B1', 'NR4A1', {'sign': -1}), ('RXRB', 'RARA', {'sign': -1}), ('RXRB', 'RARG', {'sign': -1}), ('RXRB', 'PPARG', {'sign': -1}), ('RXRB', 'THRA', {'sign': -1}), ('RXRB', 'VDR', {'sign': -1}), ('RXRB', 'THRB', {'sign': -1}), ('RXRB', 'NR2F1', {'sign': -1}), ('RXRB', 'NR2F2', {'sign': -1}), ('RXRB', 'PPARD', {'sign': -1}), ('RXRB', 'NR1H2', {'sign': -1}), ('RXRB', 'PPARA', {'sign': -1}), ('RXRB', 'NRIP1', {'sign': -1}), ('NR1H3', 'PPARA', {'sign': -1}), ('NR1H3', 'PPARD', {'sign': -1}), ('ESR2', 'RARA', {'sign': -1}), ('NR1H2', 'PPARA', {'sign': -1}), ('NR1H2', 'PPARG', {'sign': -1}), ('NR1H2', 'RXRA', {'sign': -1}), ('NR1H2', 'PPARD', {'sign': -1}), ('NR4A2', 'NR4A3', {'sign': -1}), ('NR4A2', 'RXRA', {'sign': -1}), ('NR4A2', 'RXRB', {'sign': -1}), ('NR4A2', 'RXRG', {'sign': -1}), ('NR4A2', 'NR3C1', {'sign': -1}), ('NR4A2', 'NR4A1', {'sign': -1}), ('NR4A3', 'NR4A2', {'sign': -1}), ('NR4A3', 'NR3C1', {'sign': -1}), ('NR4A3', 'NR4A1', {'sign': -1}), ('UBE2O', 'SMAD6', {'sign': -1}), ('USP4', 'BRAP', {'sign': -1}), ('PEA15', 'MAPK3', {'sign': -1}), ('PEA15', 'MAPK1', {'sign': -1}), ('IFNLR1', 'TYK2', {'sign': -1}), ('IFNLR1', 'JAK1', {'sign': -1}), ('MAP4K2', 'MAP3K1', {'sign': -1}), ('MPL', 'JAK2', {'sign': -1}), ('MPL', 'TYK2', {'sign': -1}), ('THPO', 'MPL', {'sign': -1}), ('CNTFR', 'JAK1', {'sign': -1}), ('DUSP2', 'MAPK1', {'sign': -1}), ('DUSP2', 'MAPK14', {'sign': -1}), ('SHC3', 'GRB2', {'sign': -1}), ('MAP4K4', 'MAP3K1', {'sign': -1}), ('MAP4K4', 'MAP3K7', {'sign': -1}), ('NRG2', 'ERBB3', {'sign': -1}), ('NRG2', 'ERBB4', {'sign': -1}), ('LEP', 'LEPR', {'sign': -1}), ('MAP4K5', 'MAP3K1', {'sign': -1}), ('MAP4K5', 'GSK3B', {'sign': -1}), ('LAMTOR3', 'MAPK3', {'sign': -1}), ('LAMTOR3', 'MAP2K1', {'sign': -1}), ('LAMTOR3', 'MAPK1', {'sign': -1}), ('TAOK1', 'MAP2K3', {'sign': -1}), ('TAOK1', 'STK3', {'sign': -1}), ('TAOK1', 'STK4', {'sign': -1}), ('ACVR1C', 'SMAD3', {'sign': -1}), ('ACVR1C', 'SMAD2', {'sign': -1}), ('DUSP9', 'MAPK1', {'sign': -1}), ('DUSP9', 'MAPK3', {'sign': -1}), ('DUSP9', 'MAPK14', {'sign': -1}), ('WIF1', 'WNT8A', {'sign': -1}), ('BTC', 'EGFR', {'sign': -1}), ('BTC', 'ERBB4', {'sign': -1}), ('BMP8B', 'BMPR1A', {'sign': -1}), ('BMP8B', 'ACVR1', {'sign': -1}), ('BMP8B', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP8B', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP8B', 'ACVR1_BMPR2', {'sign': -1}), ('BMP8B', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP8B', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP8B', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP8B', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP8B', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP8B', 'BMPR1B_BMPR2', {'sign': -1}), ('DTX4', 'NOTCH3', {'sign': -1}), ('CSNK1G1', 'LRP6', {'sign': -1}), ('CSNK1G1', 'LRP5', {'sign': -1}), ('CSNK1G1', 'DVL1', {'sign': -1}), ('CSNK1G1', 'NFATC1', {'sign': -1}), ('CSNK1G1', 'FOXO1', {'sign': -1}), ('CSNK1G1', 'TP53', {'sign': -1}), ('CSNK1G1', 'YWHAQ', {'sign': -1}), ('MBIP', 'MAP3K12', {'sign': -1}), ('XPO1', 'SMAD4', {'sign': -1}), ('XPO1', 'TP53', {'sign': -1}), ('HGS', 'ZFYVE9', {'sign': -1}), ('HGS', 'SMAD2', {'sign': -1}), ('LTC4S', 'NOTCH2', {'sign': -1}), ('LTC4S', 'NOTCH3', {'sign': -1}), ('LTC4S', 'NOTCH4', {'sign': -1}), ('LTC4S', 'NOTCH1', {'sign': -1}), ('LTC4S', 'MEF2C', {'sign': -1}), ('LTC4S', 'CTNNB1', {'sign': -1}), ('LTC4S', 'CDK8', {'sign': -1}), ('LTC4S', 'RBPJ', {'sign': -1}), ('LTC4S', 'TP53', {'sign': -1}), ('MAPK13', 'RCSD1', {'sign': -1}), ('MAPK13', 'EEF2K', {'sign': -1}), ('MAPK13', 'STMN1', {'sign': -1}), ('MAPK13', 'PRKD1', {'sign': -1}), ('MAPK13', 'KRT8', {'sign': -1}), ('MAPK13', 'TP53', {'sign': -1}), ('MAPK13', 'MAPT', {'sign': -1}), ('MAPK13', 'MAPKAPK5', {'sign': -1}), ('MAP4K3', 'MAP3K1', {'sign': -1}), ('MAP4K3', 'PRKCQ', {'sign': -1}), ('MAP3K13', 'MAP2K7', {'sign': -1}), ('SH2B1', 'JAK2', {'sign': -1}), ('CSNK1A1L', 'CTNNB1', {'sign': -1}), ('CSNK1A1L', 'GLI1', {'sign': -1}), ('CSNK1A1L', 'GLI3', {'sign': -1}), ('CSNK1A1L', 'GLIS2', {'sign': -1}), ('CSNK1A1L', 'LRP6', {'sign': -1}), ('CSNK1A1L', 'GLI2', {'sign': -1}), ('EXTL1', 'SHH', {'sign': -1}), ('DUSP19', 'MAPK8', {'sign': -1}), ('UBR5', 'PGR', {'sign': -1}), ('ELP1', 'MAPK8', {'sign': -1}), ('SPAG9', 'MAP2K4', {'sign': -1}), ('SPAG9', 'MAX', {'sign': -1}), ('SPAG9', 'MAP3K3', {'sign': -1}), ('SPAG9', 'MAPK14', {'sign': -1}), ('CBY1', 'CTNNB1', {'sign': -1}), ('BHLHE41', 'RBPJ', {'sign': -1}), ('IL20RB', 'TYK2', {'sign': -1}), ('IL20RB', 'JAK1', {'sign': -1}), ('CNKSR2', 'RAF1', {'sign': -1}), ('FZD3', 'CXCL1', {'sign': -1}), ('FZD3', 'DVL1', {'sign': -1}), ('PPP1CC', 'TGFBR1', {'sign': -1}), ('PPP1CC', 'CAMK2A', {'sign': -1}), ('PPP1CC', 'BCL2', {'sign': -1}), ('PPP1CC', 'AXIN1', {'sign': -1}), ('PPP1CC', 'CDK9', {'sign': -1}), ('PPP1CC', 'MDM2', {'sign': -1}), ('PPP1CC', 'IFIH1', {'sign': -1}), ('PPP1CC', 'EIF2S1', {'sign': -1}), ('PPP1CC', 'TP53', {'sign': -1}), ('PPP1CC', 'AKT1', {'sign': -1}), ('PPP1CC', 'CASP2', {'sign': -1}), ('PPP1CC', 'IKZF1', {'sign': -1}), ('PPP1CC', 'NOS3', {'sign': -1}), ('PPP1CC', 'CDC25C', {'sign': -1}), ('WDR83', 'RAF1', {'sign': -1}), ('WDR83', 'MAPK3', {'sign': -1}), ('WDR83', 'MAP2K1', {'sign': -1}), ('WWP1', 'SMAD7', {'sign': -1}), ('WWP1', 'SMAD2', {'sign': -1}), ('WWP1', 'TGFBR1', {'sign': -1}), ('TPBG', 'EGFR', {'sign': -1}), ('TGIF1', 'WWP1', {'sign': -1}), ('POFUT1', 'MFNG', {'sign': -1}), ('POFUT1', 'LFNG', {'sign': -1}), ('POFUT1', 'GALM', {'sign': -1}), ('POFUT1', 'NOTCH1', {'sign': -1}), ('NEURL1', 'JAG1', {'sign': -1}), ('MTSS1', 'GLI1', {'sign': -1}), ('MTSS1', 'GLIS2', {'sign': -1}), ('MTSS1', 'SUFU', {'sign': -1}), ('MTSS1', 'RAC1', {'sign': -1}), ('GRK6', 'SMO', {'sign': -1}), ('GRK6', 'LRP6', {'sign': -1}), ('GRK6', 'TYRO3', {'sign': -1}), ('GRK6', 'SLC9A3R1', {'sign': -1}), ('GRK6', 'LTB4R', {'sign': -1}), ('GRK6', 'BDKRB2', {'sign': -1}), ('GRK6', 'CXCR4', {'sign': -1}), ('DISP2', 'SHH', {'sign': -1}), ('DISP3', 'SHH', {'sign': -1}), ('TRIM33', 'SMAD4', {'sign': -1}), ('TRIM33', 'SMAD3', {'sign': -1}), ('TRIM33', 'SMAD2', {'sign': -1}), ('CNKSR1', 'RAF1', {'sign': -1}), ('CNKSR1', 'RASSF1', {'sign': -1}), ('SPOP', 'CUL3', {'sign': -1}), ('SPOP', 'GLI2', {'sign': -1}), ('SPOP', 'NCOA3', {'sign': -1}), ('SPOP', 'GLI3', {'sign': -1}), ('SPOP', 'DAXX', {'sign': -1}), ('SPOP', 'PDX1', {'sign': -1}), ('CUL3', 'GLIS2', {'sign': -1}), ('CUL3', 'KCTD10', {'sign': -1}), ('CUL3', 'TNFAIP1', {'sign': -1}), ('CUL3', 'HSF2', {'sign': -1}), ('CUL3', 'KCTD13', {'sign': -1}), ('MIB2', 'JAG2', {'sign': -1}), ('RAB11A', 'JAG1', {'sign': -1}), ('RANBP3', 'CTNNB1', {'sign': -1}), ('RANBP3', 'SMAD2', {'sign': -1}), ('RANBP3', 'SMAD3', {'sign': -1}), ('SNX9', 'EGFR', {'sign': -1}), ('SNX9', 'DNM2', {'sign': -1}), ('SNX9', 'DNM1', {'sign': -1}), ('ACTR2', 'ACVR1B', {'sign': -1}), ('GDF11', 'ACTR2', {'sign': -1}), ('GDF11', 'ACVR2B', {'sign': -1}), ('GDF11', 'ACVR1B', {'sign': -1}), ('GDF11', 'ACVR2A', {'sign': -1}), ('GDF1', 'ACTR2', {'sign': -1}), ('BMP15', 'ACTR2', {'sign': -1}), ('BMP15', 'BMPR2', {'sign': -1}), ('BMP15', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP15', 'BMPR1B', {'sign': -1}), ('NODAL', 'ACVR2B', {'sign': -1}), ('NODAL', 'ACVR1C', {'sign': -1}), ('NODAL', 'ACVR1B', {'sign': -1}), ('NODAL', 'ACVR1B_ACVR2B', {'sign': -1}), ('NODAL', 'ACVR1C_ACVR2A', {'sign': -1}), ('NODAL', 'ACVR1C_ACVR2B', {'sign': -1}), ('NODAL', 'ACVR2A', {'sign': -1}), ('NUMBL', 'ITCH', {'sign': -1}), ('SOCS2', 'IGF1R', {'sign': -1}), ('SOCS2', 'LEPR', {'sign': -1}), ('SOCS2', 'EPOR', {'sign': -1}), ('CTDSP1', 'SMAD1', {'sign': -1}), ('CTDSP1', 'SMAD3', {'sign': -1}), ('CTDSP1', 'SMAD2', {'sign': -1}), ('CTDSP1', 'POLR2A', {'sign': -1}), ('CTDSP1', 'TWIST1', {'sign': -1}), ('CTDSP2', 'SMAD1', {'sign': -1}), ('CTDSP2', 'SMAD3', {'sign': -1}), ('CTDSP2', 'SMAD2', {'sign': -1}), ('BCL9', 'CTNNB1', {'sign': -1}), ('BCL9', 'PYGO1', {'sign': -1}), ('CTDNEP1', 'BMPR1A', {'sign': -1}), ('CTDNEP1', 'LPIN1', {'sign': -1}), ('IFNK', 'IFNAR1', {'sign': -1}), ('IFNK', 'IFNAR2', {'sign': -1}), ('IL36G', 'IFNAR1', {'sign': -1}), ('IL36G', 'IFNAR2', {'sign': -1}), ('IFNL2', 'IL10RB', {'sign': -1}), ('IFNL2', 'IFNLR1', {'sign': -1}), ('IFNL3', 'IL10RB', {'sign': -1}), ('IFNL3', 'IFNLR1', {'sign': -1}), ('MDK', 'NOTCH2', {'sign': -1}), ('MDK', 'ALK', {'sign': -1}), ('INPPL1', 'MAPK8IP1', {'sign': -1}), ('HHAT', 'SHH', {'sign': -1}), ('MFAP2', 'NOTCH1', {'sign': -1}), ('CDK8', 'NOTCH1', {'sign': -1}), ('CDK8', 'SMAD1', {'sign': -1}), ('CDK8', 'SMAD3', {'sign': -1}), ('CDK8', 'E2F1', {'sign': -1}), ('CDK8', 'CCNH', {'sign': -1}), ('PTPRT', 'STAT3', {'sign': -1}), ('PTPRT', 'PXN', {'sign': -1}), ('FKBP1A', 'TGFBR1', {'sign': -1}), ('FKBP1A', 'PPP3R1', {'sign': -1}), ('LRRFIP2', 'DVL3', {'sign': -1}), ('CAPRIN2', 'LRP6', {'sign': -1}), ('PDGFD', 'PDGFRB', {'sign': -1}), ('GRB14', 'INSR', {'sign': -1}), ('FGF6', 'FGFR2', {'sign': -1}), ('FGF6', 'FGFR4', {'sign': -1}), ('FGF17', 'FGFR2', {'sign': -1}), ('FGF17', 'FGFR1', {'sign': -1}), ('FGF17', 'FGFR3', {'sign': -1}), ('FGF17', 'FGFR4', {'sign': -1}), ('FGF18', 'FGFR2', {'sign': -1}), ('FGF18', 'FGFR1', {'sign': -1}), ('FGF18', 'FGFR3', {'sign': -1}), ('FGF18', 'FGFR4', {'sign': -1}), ('FGF22', 'FGFR2', {'sign': -1}), ('FGF22', 'FGFR1', {'sign': -1}), ('FGFR3', 'STAT3', {'sign': -1}), ('FGFR3', 'STAT1', {'sign': -1}), ('FGFR3', 'PLCG1', {'sign': -1}), ('FLT4', 'SHC1', {'sign': -1}), ('FLT4', 'RPS6KA3', {'sign': -1}), ('RANBP9', 'DYRK1B', {'sign': -1}), ('MST1R', 'GRAP', {'sign': -1}), ('MST1R', 'YWHAB', {'sign': -1}), ('MST1R', 'YWHAQ', {'sign': -1}), ('MST1R', 'MET', {'sign': -1}), ('NTRK3', 'PLCG1', {'sign': -1}), ('NTRK3', 'SHC1', {'sign': -1}), ('EFNB1', 'EPHB1', {'sign': -1}), ('EFNB1', 'EPHB2', {'sign': -1}), ('EFNB1', 'EPHB3', {'sign': -1}), ('EFNB1', 'EPHB4', {'sign': -1}), ('EFNB1', 'EPHB6', {'sign': -1}), ('EPHB1', 'GRB7', {'sign': -1}), ('EPHB1', 'ACP1', {'sign': -1}), ('EPHB1', 'NCK1', {'sign': -1}), ('EPHB1', 'CASKIN1', {'sign': -1}), ('EPHB1', 'NRCAM', {'sign': -1}), ('SYNJ1', 'MYO1E', {'sign': -1}), ('ITSN1', 'CDC42', {'sign': -1}), ('PTN', 'ALK', {'sign': -1}), ('PTN', 'PTPRZ1', {'sign': -1}), ('PTN', 'SDC3', {'sign': -1}), ('ALK', 'PLCG1', {'sign': -1}), ('ALK', 'STAT3', {'sign': -1}), ('ALK', 'SHC3', {'sign': -1}), ('ALK', 'SHC1', {'sign': -1}), ('ALK', 'SFPQ', {'sign': -1}), ('ALK', 'PTPN11', {'sign': -1}), ('PTPRZ1', 'ALK', {'sign': -1}), ('PTPRZ1', 'ARHGAP35', {'sign': -1}), ('PTPRB', 'ALK', {'sign': -1}), ('PTPRB', 'MAPK3', {'sign': -1}), ('PTPRB', 'MET', {'sign': -1}), ('PTPRB', 'KDR', {'sign': -1}), ('PTPRB', 'INSR', {'sign': -1}), ('PTPRB', 'GHR', {'sign': -1}), ('TIE1', 'TEK', {'sign': -1}), ('ANGPTL1', 'TEK', {'sign': -1}), ('ROR1', 'SRC', {'sign': -1}), ('DDR2', 'SHC1', {'sign': -1}), ('AATK', 'STK39', {'sign': -1}), ('AATK', 'CDK5R1', {'sign': -1}), ('DOK4', 'CRK', {'sign': -1}), ('DOK4', 'SRC', {'sign': -1}), ('DOK4', 'FYN', {'sign': -1}), ('RYBP', 'ABL1', {'sign': -1}), ('RFX1', 'ABL1', {'sign': -1}), ('CSK', 'YTHDC1', {'sign': -1}), ('CSK', 'LCK', {'sign': -1}), ('CSK', 'PXN', {'sign': -1}), 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'BMPR1A_BMPR2', {'sign': -1}), ('BMP5', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP5', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP5', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP5', 'BMPR1A', {'sign': -1}), ('BMP8A', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP8A', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP8A', 'ACVR1_BMPR2', {'sign': -1}), ('BMP8A', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP8A', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP8A', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP8A', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP8A', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP8A', 'BMPR1B_BMPR2', {'sign': -1}), ('CCL18', 'CCR3', {'sign': -1}), ('CCL18', 'CCR8', {'sign': -1}), ('CCL18', 'CCR1', {'sign': -1}), ('CCL28', 'CCR10', {'sign': -1}), ('CCL28', 'CCR3', {'sign': -1}), ('CCL28', 'ACKR2', {'sign': -1}), ('CD48', 'CD244', {'sign': -1}), ('CD58', 'CD2', {'sign': -1}), ('FGF16', 'FGFR1', {'sign': -1}), ('FGF16', 'FGFR2', {'sign': -1}), ('FGF16', 'FGFR3', {'sign': -1}), ('FGF16', 'FGFR4', {'sign': -1}), ('FGF20', 'FGFR1', {'sign': -1}), ('FGF20', 'FGFR2', {'sign': -1}), ('FGF20', 'FGFR3', {'sign': -1}), ('FGF20', 'FGFR4', {'sign': -1}), ('FGF21', 'FGFR1', {'sign': -1}), ('FGF21', 'FGFR3', {'sign': -1}), ('FGF21', 'FGFR4', {'sign': -1}), ('FGF21', 'FGFR2', {'sign': -1}), ('GDF7', 'ACVR2A_BMPR1A', {'sign': -1}), ('GDF7', 'ACVR2B_BMPR1A', {'sign': -1}), ('GDF7', 'BMPR1A_BMPR2', {'sign': -1}), ('GDF7', 'ACVR2A_BMPR1B', {'sign': -1}), ('GDF7', 'ACVR2B_BMPR1B', {'sign': -1}), ('GDF7', 'BMPR1B_BMPR2', {'sign': -1}), ('GDF7', 'BMPR2', {'sign': -1}), ('GDF7', 'BMPR1A', {'sign': -1}), ('GDF7', 'ACVR2A', {'sign': -1}), ('GH2', 'GHR', {'sign': -1}), ('HLA-A', 'KIR3DL2', {'sign': -1}), ('HLA-A', 'KIR3DL1', {'sign': -1}), ('HLA-A', 'KLRD1', {'sign': -1}), ('HLA-B', 'KIR3DL1', {'sign': -1}), ('HLA-B', 'KIR3DL2', {'sign': -1}), ('HLA-B', 'KIR2DL3', {'sign': -1}), ('HLA-B', 'KLRD1', {'sign': -1}), ('HLA-C', 'KIR2DL1', {'sign': -1}), ('HLA-C', 'KIR2DL2', {'sign': -1}), ('HLA-C', 'KIR2DL3', {'sign': -1}), ('HLA-C', 'KIR2DS1', {'sign': 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('LAMB1', 'ITGA6', {'sign': -1}), ('LAMB1', 'ITGB4', {'sign': -1}), ('LAMB1', 'CD151', {'sign': -1}), ('ULBP1', 'KLRK1', {'sign': -1}), ('HRG', 'ERBB3', {'sign': -1}), ('IFNA7', 'IFNAR2', {'sign': -1}), ('IFNA7', 'IFNAR1', {'sign': -1}), ('IL17C', 'IL17RE', {'sign': -1}), ('LAMA5', 'ITGA6', {'sign': -1}), ('LAMA5', 'ITGB4', {'sign': -1}), ('LAMA5', 'CD151', {'sign': -1}), ('LAMC1', 'ITGA6', {'sign': -1}), ('LAMC1', 'ITGB4', {'sign': -1}), ('IL36A', 'IL1RL2', {'sign': -1}), ('LAMC2', 'ITGA6', {'sign': -1}), ('LAMC2', 'ITGB1', {'sign': -1}), ('LAMC2', 'ITGA3', {'sign': -1}), ('LAMC2', 'ITGB4', {'sign': -1}), ('NID1', 'PTPRF', {'sign': -1}), ('ADAM2', 'ITGB1', {'sign': -1}), ('ADAM2', 'ITGA6', {'sign': -1}), ('INHBE', 'ACVR2B', {'sign': -1}), ('INHBE', 'ACVR2A', {'sign': -1}), ('HDC', 'HRH1', {'sign': -1}), ('HDC', 'HRH2', {'sign': -1}), ('HDC', 'HRH3', {'sign': -1}), ('HDC', 'HRH4', {'sign': -1}), ('INHBB', 'ACVR2B', {'sign': -1}), ('INHBB', 'ACVR1B', {'sign': -1}), ('INHBB', 'ACVR2A', {'sign': -1}), ('INHBB', 'ACVR1C', {'sign': -1}), ('INHBB', 'ACVR1', {'sign': -1}), ('PCSK9', 'LDLR', {'sign': -1}), ('SEMA3E', 'PLXND1', {'sign': -1}), ('INHBC', 'ACVR2B', {'sign': -1}), ('INHBC', 'ACVR2A', {'sign': -1}), ('INHBC', 'ACVR1', {'sign': -1}), ('INHBC', 'ACVR1B', {'sign': -1}), ('CSH1', 'PRLR', {'sign': -1}), ('SEMA6D', 'PLXNA1', {'sign': -1}), ('SEMA6D', 'KDR', {'sign': -1}), ('SLIT3', 'ROBO2', {'sign': -1}), ('SLIT3', 'ROBO1', {'sign': -1}), ('CXCL14', 'CXCR4', {'sign': -1}), ('ICAM4', 'ITGAM', {'sign': -1}), ('ICAM4', 'ITGAL', {'sign': -1}), ('ICAM4', 'ITGB3', {'sign': -1}), ('ICAM4', 'ITGAV', {'sign': -1}), ('ICAM4', 'ITGA2B', {'sign': -1}), ('ICAM4', 'ITGB2', {'sign': -1}), ('GDF9', 'BMPR1B', {'sign': -1}), ('GDF9', 'ACVR2A', {'sign': -1}), ('GDF9', 'BMPR1A', {'sign': -1}), ('GDF9', 'BMPR2', {'sign': -1}), ('GDF9', 'TGFBR1', {'sign': -1}), ('ZG16B', 'CXCR4', {'sign': -1}), ('LAMA1', 'ITGA7', {'sign': -1}), ('LAMA1', 'ITGB8', {'sign': -1}), ('LAMA1', 'ITGA2', {'sign': -1}), ('LAMA1', 'RPSA', {'sign': -1}), ('LAMB3', 'ITGA6', {'sign': -1}), ('LAMB3', 'ITGB4', {'sign': -1}), ('CCN1', 'ITGAM', {'sign': -1}), ('CCN1', 'ITGB3', {'sign': -1}), ('CCN1', 'ITGA5', {'sign': -1}), ('CCN1', 'ITGB2', {'sign': -1}), ('LAMA2', 'ITGA7', {'sign': -1}), ('LAMA2', 'ITGB4', {'sign': -1}), ('LAMA2', 'RPSA', {'sign': -1}), ('LAMA2', 'ITGB1', {'sign': -1}), ('LAMA2', 'ITGA6', {'sign': -1}), ('LAMA2', 'DAG1', {'sign': -1}), ('LAMA3', 'ITGB4', {'sign': -1}), ('LAMB2', 'ITGB4', {'sign': -1}), ('LAMB2', 'RPSA', {'sign': -1}), ('RAET1L', 'KLRK1', {'sign': -1}), ('ULBP3', 'KLRK1', {'sign': -1}), ('RAET1E', 'KLRK1', {'sign': -1}), ('RAET1G', 'KLRK1', {'sign': -1}), ('SERPINE2', 'LRP1', {'sign': -1}), ('LRPAP1', 'LRP1', {'sign': -1}), ('LRPAP1', 'VLDLR', {'sign': -1}), ('RNASE2', 'TLR2', {'sign': -1}), ('SOST', 'LRP6', {'sign': -1}), ('SOST', 'LRP5', {'sign': -1}), ('CD24', 'SELP', {'sign': -1}), ('IFNA16', 'IFNAR1', {'sign': -1}), ('IFNA16', 'IFNAR2', {'sign': -1}), ('IFNA14', 'IFNAR1', {'sign': -1}), ('IFNA14', 'IFNAR2', {'sign': -1}), ('IFNA4', 'IFNAR1', {'sign': -1}), ('IFNA4', 'IFNAR2', {'sign': -1}), ('IFNA5', 'IFNAR1', {'sign': -1}), ('IFNA5', 'IFNAR2', {'sign': -1}), ('IFNA6', 'IFNAR1', {'sign': -1}), ('IFNA6', 'IFNAR2', {'sign': -1}), ('IFNA10', 'IFNAR1', {'sign': -1}), ('IFNA10', 'IFNAR2', {'sign': -1}), ('IFNA8', 'IFNAR1', {'sign': -1}), ('IFNA8', 'IFNAR2', {'sign': -1}), ('IFNE', 'IFNAR1', {'sign': -1}), ('IFNE', 'IFNAR2', {'sign': -1}), ('IFNA21', 'IFNAR1', {'sign': -1}), ('IFNA21', 'IFNAR2', {'sign': -1}), ('IFNA2', 'IFNAR1', {'sign': -1}), ('IFNA2', 'IFNAR2', {'sign': -1}), ('IL17F', 'IL17RC', {'sign': -1}), ('IL17F', 'IL17RA', {'sign': -1}), ('CHAD', 'ITGA2', {'sign': -1}), ('CHAD', 'ITGB1', {'sign': -1}), ('TAC4', 'TACR1', {'sign': -1}), ('LEFTY2', 'ACVR2B', {'sign': -1}), ('ICAM2', 'ITGAL', {'sign': -1}), ('ICAM2', 'ITGB2', {'sign': -1}), ('CD59', 'CD2', {'sign': -1}), ('CXCL17', 'GPR35', {'sign': -1}), ('NAMPT', 'INSR', {'sign': -1}), ('ENHO', 'GPR19', {'sign': -1}), ('BAG6', 'NCR3', {'sign': -1}), ('HLA-F', 'KIR3DL1', {'sign': -1}), ('HLA-F', 'KIR3DL2', {'sign': -1}), ('HLA-E', 'KLRC1', {'sign': -1}), ('HLA-E', 'KLRC2', {'sign': -1}), ('HLA-E', 'KLRD1', {'sign': -1}), ('ADAM23', 'ITGA5', {'sign': -1}), ('ADAM23', 'ITGB3', {'sign': -1}), ('COL5A3', 'SDC3', {'sign': -1}), ('LEAP2', 'GHSR', {'sign': -1}), ('NXPH3', 'NRXN1', {'sign': -1}), ('NXPH3', 'NRXN2', {'sign': -1}), ('NXPH3', 'NRXN3', {'sign': -1}), ('PODXL2', 'SELL', {'sign': -1}), ('PRND', 'RPSA', {'sign': -1}), ('PTDSS1', 'JMJD6', {'sign': -1}), ('PTDSS1', 'SCARB1', {'sign': -1}), ('SERPING1', 'LRP1', {'sign': -1}), ('TFF2', 'CXCR4', {'sign': -1}), ('GPR15LG', 'GPR15', {'sign': -1}), ('DUSP18', 'CD151', {'sign': -1}), ('CDK19', 'EIF3F', {'sign': -1}), ('PTP4A1', 'ATF7', {'sign': -1}), ('PTPRU', 'CTNNB1', {'sign': -1}), ('PTPRM', 'CTNND1', {'sign': -1}), ('HIPK4', 'TP53', {'sign': -1}), ('FRK', 'PTEN', {'sign': -1}), ('MYT1', 'CDK1', {'sign': -1}), ('ENPEP', 'CCK', {'sign': -1}), ('ADAMTS1', 'VCAN', {'sign': -1}), ('MMP26', 'MMP9', {'sign': -1}), ('FCGR3A', 'LCK', {'sign': -1}), ('TASP1', 'GTF2A1', {'sign': -1}), ('NAA10', 'HIF1A', {'sign': -1}), ('ECE1', 'EDN1', {'sign': -1}), ('CSNK1G3', 'TP53', {'sign': -1}), ('CSNK1G3', 'YWHAQ', {'sign': -1})])" + ] + }, + "execution_count": 12, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ - "*This section is under construction, currently CORNETO only works when networks are built from a file, the conversion from networkx graphs will be released in the future...*" + "graph.edges(data=True)" ] }, { "cell_type": "code", - "execution_count": 12, + "execution_count": 24, "metadata": {}, "outputs": [ { - "name": "stdout", - "output_type": "stream", - "text": [ - "(CORNETO) Jun 13 02:11:26 PM - INFO : 1/1 inputs mapped to the graph\n", - "(CORNETO) Jun 13 02:11:26 PM - INFO : 13/25 outputs mapped to the graph\n", - "(CORNETO) Jun 13 02:11:26 PM - INFO : Pruning the graph with size: V x E = (4946, 13258)...\n", - "(CORNETO) Jun 13 02:11:26 PM - INFO : Finished. Final size: V x E = (1183, 5823).\n", - "(CORNETO) Jun 13 02:11:26 PM - INFO : 1/1 inputs after pruning.\n", - "(CORNETO) Jun 13 02:11:26 PM - INFO : 7/13 outputs after pruning.\n", - "(CORNETO) Jun 13 02:11:26 PM - INFO : Converting into a flow graph...\n", - "(CORNETO) Jun 13 02:11:27 PM - INFO : Creating a network flow problem...\n", - "(CORNETO) Jun 13 02:11:27 PM - INFO : Preprocess completed.\n", - "===============================================================================\n", - " CVXPY \n", - " v1.4.3 \n", - "===============================================================================\n", - "(CVXPY) Jun 13 02:11:27 PM: Your problem has 27027 variables, 22 constraints, and 0 parameters.\n", - "(CVXPY) Jun 13 02:11:27 PM: It is compliant with the following grammars: DCP, DQCP\n", - "(CVXPY) Jun 13 02:11:27 PM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n", - "(CVXPY) Jun 13 02:11:27 PM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n", - "(CVXPY) Jun 13 02:11:27 PM: Your problem is compiled with the CPP canonicalization backend.\n", - "-------------------------------------------------------------------------------\n", - " Compilation \n", - "-------------------------------------------------------------------------------\n", - "(CVXPY) Jun 13 02:11:27 PM: Compiling problem (target solver=GUROBI).\n", - "(CVXPY) Jun 13 02:11:27 PM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> GUROBI\n", - "(CVXPY) Jun 13 02:11:27 PM: Applying reduction CvxAttr2Constr\n", - "(CVXPY) Jun 13 02:11:27 PM: Applying reduction Qp2SymbolicQp\n", - "(CVXPY) Jun 13 02:11:27 PM: Applying reduction QpMatrixStuffing\n", - "(CVXPY) Jun 13 02:11:27 PM: Applying reduction GUROBI\n", - "(CVXPY) Jun 13 02:11:27 PM: Finished problem compilation (took 1.223e-01 seconds).\n", - "-------------------------------------------------------------------------------\n", - " Numerical solver \n", - "-------------------------------------------------------------------------------\n", - "(CVXPY) Jun 13 02:11:27 PM: Invoking solver GUROBI to obtain a solution.\n", - "Set parameter Username\n", - "Academic license - for non-commercial use only - expires 2025-06-13\n", - "Set parameter QCPDual to value 1\n", - "Gurobi Optimizer version 11.0.1 build v11.0.1rc0 (linux64 - \"Ubuntu 22.04.1 LTS\")\n", - "\n", - "CPU model: 11th Gen Intel(R) Core(TM) i7-1165G7 @ 2.80GHz, instruction set [SSE2|AVX|AVX2|AVX512]\n", - "Thread count: 4 physical cores, 8 logical processors, using up to 8 threads\n", - "\n", - "Optimize a model with 65816 rows, 27027 columns and 153670 nonzeros\n", - "Model fingerprint: 0x7da168a8\n", - "Variable types: 7058 continuous, 19969 integer (19969 binary)\n", - "Coefficient statistics:\n", - " Matrix range [1e-03, 1e+03]\n", - " Objective range [1e-02, 1e+00]\n", - " Bounds range [1e+00, 1e+00]\n", - " RHS range [1e-03, 1e+03]\n", - "Presolve removed 29294 rows and 2359 columns\n", - "Presolve time: 0.36s\n", - "Presolved: 36522 rows, 24668 columns, 109199 nonzeros\n", - "Variable types: 6629 continuous, 18039 integer (18039 binary)\n", - "Deterministic concurrent LP optimizer: primal and dual simplex\n", - "Showing primal log only...\n", - "\n", - "Concurrent spin time: 0.01s\n", - "\n", - "Solved with dual simplex\n", - "Extra simplex iterations after uncrush: 4\n", - "\n", - "Root relaxation: objective -7.813108e+00, 1041 iterations, 0.18 seconds (0.14 work units)\n", - "\n", - " Nodes | Current Node | Objective Bounds | Work\n", - " Expl Unexpl | Obj Depth IntInf | Incumbent BestBd Gap | It/Node Time\n", - "\n", - " 0 0 -7.81311 0 48 - -7.81311 - - 0s\n", - " 0 0 -7.80313 0 47 - -7.80313 - - 0s\n", - "H 0 0 -0.9700000 -7.80313 704% - 1s\n", - "H 0 0 -1.9100000 -7.80313 309% - 1s\n", - " 0 0 -7.79500 0 57 -1.91000 -7.79500 308% - 1s\n", - " 0 0 -7.79000 0 70 -1.91000 -7.79000 308% - 2s\n", - " 0 0 -7.79000 0 52 -1.91000 -7.79000 308% - 2s\n", - " 0 0 -7.79000 0 52 -1.91000 -7.79000 308% - 2s\n", - " 0 0 -7.79000 0 134 -1.91000 -7.79000 308% - 2s\n", - " 0 0 -7.79000 0 116 -1.91000 -7.79000 308% - 3s\n", - "H 0 0 -1.9300000 -7.79000 304% - 4s\n", - " 0 0 -7.79000 0 8 -1.93000 -7.79000 304% - 4s\n", - " 0 0 -7.79000 0 41 -1.93000 -7.79000 304% - 4s\n", - " 0 0 -7.79000 0 26 -1.93000 -7.79000 304% - 5s\n", - " 0 0 -7.79000 0 47 -1.93000 -7.79000 304% - 6s\n", - "H 0 0 -6.6800000 -7.79000 16.6% - 6s\n", - " 0 0 -7.79000 0 8 -6.68000 -7.79000 16.6% - 6s\n", - "H 0 0 -6.7300000 -7.79000 15.8% - 6s\n", - " 0 0 -7.79000 0 96 -6.73000 -7.79000 15.8% - 7s\n", - " 0 0 -7.79000 0 8 -6.73000 -7.79000 15.8% - 7s\n", - "H 0 0 -6.7800000 -7.79000 14.9% - 8s\n", - " 0 0 -7.79000 0 8 -6.78000 -7.79000 14.9% - 8s\n", - "H 0 0 -6.7900000 -7.79000 14.7% - 8s\n", - " 0 0 -7.79000 0 8 -6.79000 -7.79000 14.7% - 8s\n", - " 0 0 -7.79000 0 8 -6.79000 -7.79000 14.7% - 8s\n", - " 0 2 -7.79000 0 8 -6.79000 -7.79000 14.7% - 9s\n", - " 27 31 -7.79000 6 63 -6.79000 -7.79000 14.7% 87.4 10s\n", - "H 28 31 -7.7500000 -7.79000 0.52% 84.2 10s\n", - " 182 176 -7.78996 37 63 -7.75000 -7.79000 0.52% 61.6 15s\n", - "H 330 247 -7.7600000 -7.79000 0.39% 51.5 19s\n", - " 352 273 -7.77996 74 49 -7.76000 -7.79000 0.39% 50.3 20s\n", - "H 479 267 -7.7700000 -7.79000 0.26% 44.9 24s\n", - " 535 249 -7.78998 20 24 -7.77000 -7.79000 0.26% 43.0 26s\n", - "H 710 240 -7.7800000 -7.79000 0.13% 40.5 28s\n", - " 816 32 -7.79000 34 8 -7.78000 -7.79000 0.13% 43.4 30s\n", - "\n", - "Cutting planes:\n", - " Gomory: 1\n", - " MIR: 1\n", - " Flow cover: 2\n", - "\n", - "Explored 816 nodes (47937 simplex iterations) in 30.99 seconds (26.21 work units)\n", - "Thread count was 8 (of 8 available processors)\n", - "\n", - "Solution count 10: -7.78 -7.77 -7.76 ... -1.91\n", - "No other solutions better than -7.78\n", - "\n", - "Optimal solution found (tolerance 1.00e-04)\n", - "Best objective -7.780000000000e+00, best bound -7.780000000000e+00, gap 0.0000%\n", - "-------------------------------------------------------------------------------\n", - " Summary \n", - "-------------------------------------------------------------------------------\n", - "(CVXPY) Jun 13 02:11:59 PM: Problem status: optimal\n", - "(CVXPY) Jun 13 02:11:59 PM: Optimal value: 1.822e+01\n", - "(CVXPY) Jun 13 02:11:59 PM: Compilation took 1.223e-01 seconds\n", - "(CVXPY) Jun 13 02:11:59 PM: Solver (including time spent in interface) took 3.154e+01 seconds\n", - "(CORNETO) Jun 13 02:11:59 PM - INFO : Finished in 32.91 s.\n" + "ename": "AttributeError", + "evalue": "module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mKeyError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:159\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 158\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[0;32m--> 159\u001b[0m _callable \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mtype\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_lazy_import_callables\u001b[49m\u001b[43m[\u001b[49m\u001b[43mattr\u001b[49m\u001b[43m]\u001b[49m\n\u001b[1;32m 160\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning lazy-callable \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(attr))\n", + "\u001b[0;31mKeyError\u001b[0m: 'causal'", + "\nDuring handling of the above exception, another exception occurred:\n", + "\u001b[0;31mAttributeError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[24], line 1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m importlib\u001b[38;5;241m.\u001b[39mreload(\u001b[43mnc\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mmethods\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mcausal\u001b[49m)\n", + "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:167\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 162\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m (\u001b[38;5;167;01mAttributeError\u001b[39;00m, \u001b[38;5;167;01mKeyError\u001b[39;00m) \u001b[38;5;28;01mas\u001b[39;00m err:\n\u001b[1;32m 163\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mProceeding to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m, \u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 164\u001b[0m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mfrom requested value \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 165\u001b[0m \u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 166\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124m__name__\u001b[39m\u001b[38;5;124m\"\u001b[39m), attr))\n\u001b[0;32m--> 167\u001b[0m \u001b[43m_load_module\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\n\u001b[1;32m 168\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning value \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 169\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)))\n\u001b[1;32m 170\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)\n", + "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:536\u001b[0m, in \u001b[0;36m_load_module\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 533\u001b[0m cached_data \u001b[38;5;241m=\u001b[39m _clean_lazymodule(module)\n\u001b[1;32m 534\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[1;32m 535\u001b[0m \u001b[38;5;66;03m# Get Python to do the real import!\u001b[39;00m\n\u001b[0;32m--> 536\u001b[0m \u001b[43mreload_module\u001b[49m\u001b[43m(\u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m \n\u001b[1;32m 537\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m:\n\u001b[1;32m 538\u001b[0m \u001b[38;5;66;03m# Loading failed. We reset our lazy state.\u001b[39;00m\n\u001b[1;32m 539\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mFailed to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m. Resetting...\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 540\u001b[0m \u001b[38;5;241m.\u001b[39mformat(modname))\n", + "File \u001b[0;32m/usr/lib/python3.10/importlib/__init__.py:169\u001b[0m, in \u001b[0;36mreload\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 167\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m spec \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[1;32m 168\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mModuleNotFoundError\u001b[39;00m(\u001b[38;5;124mf\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mspec not found for the module \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mname\u001b[38;5;132;01m!r}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m, name\u001b[38;5;241m=\u001b[39mname)\n\u001b[0;32m--> 169\u001b[0m \u001b[43m_bootstrap\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_exec\u001b[49m\u001b[43m(\u001b[49m\u001b[43mspec\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 170\u001b[0m \u001b[38;5;66;03m# The module may have replaced itself in sys.modules!\u001b[39;00m\n\u001b[1;32m 171\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m sys\u001b[38;5;241m.\u001b[39mmodules[name]\n", + "File \u001b[0;32m:619\u001b[0m, in \u001b[0;36m_exec\u001b[0;34m(spec, module)\u001b[0m\n", + "File \u001b[0;32m:883\u001b[0m, in \u001b[0;36mexec_module\u001b[0;34m(self, module)\u001b[0m\n", + "File \u001b[0;32m:241\u001b[0m, in \u001b[0;36m_call_with_frames_removed\u001b[0;34m(f, *args, **kwds)\u001b[0m\n", + "File \u001b[0;32m~/networkcommons/networkcommons/methods.py:1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", + "File \u001b[0;32m~/networkcommons/networkcommons/_methods/__init__.py:21\u001b[0m\n\u001b[1;32m 16\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 17\u001b[0m \u001b[38;5;124;03mNetwork based inference methods and network operations.\u001b[39;00m\n\u001b[1;32m 18\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 20\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mgraph\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[0;32m---> 21\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mcausal\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[1;32m 22\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mmoon\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", + "\u001b[0;31mAttributeError\u001b[0m: module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'" + ] + } + ], + "source": [ + "importlib.reload(nc.methods.causal)" + ] + }, + { + "cell_type": "code", + "execution_count": 20, + "metadata": {}, + "outputs": [ + { + "ename": "AttributeError", + "evalue": "module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mKeyError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:159\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 158\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[0;32m--> 159\u001b[0m _callable \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mtype\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_lazy_import_callables\u001b[49m\u001b[43m[\u001b[49m\u001b[43mattr\u001b[49m\u001b[43m]\u001b[49m\n\u001b[1;32m 160\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning lazy-callable \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(attr))\n", + "\u001b[0;31mKeyError\u001b[0m: 'causal'", + "\nDuring handling of the above exception, another exception occurred:\n", + "\u001b[0;31mAttributeError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[20], line 1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m corneto_graph \u001b[38;5;241m=\u001b[39m \u001b[43mnc\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mmethods\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mcausal\u001b[49m\u001b[38;5;241m.\u001b[39mto_cornetograph(graph)\n", + "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:167\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 162\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m (\u001b[38;5;167;01mAttributeError\u001b[39;00m, \u001b[38;5;167;01mKeyError\u001b[39;00m) \u001b[38;5;28;01mas\u001b[39;00m err:\n\u001b[1;32m 163\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mProceeding to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m, \u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 164\u001b[0m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mfrom requested value \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 165\u001b[0m \u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 166\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124m__name__\u001b[39m\u001b[38;5;124m\"\u001b[39m), attr))\n\u001b[0;32m--> 167\u001b[0m \u001b[43m_load_module\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\n\u001b[1;32m 168\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning value \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 169\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)))\n\u001b[1;32m 170\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)\n", + "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:536\u001b[0m, in \u001b[0;36m_load_module\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 533\u001b[0m cached_data \u001b[38;5;241m=\u001b[39m _clean_lazymodule(module)\n\u001b[1;32m 534\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[1;32m 535\u001b[0m \u001b[38;5;66;03m# Get Python to do the real import!\u001b[39;00m\n\u001b[0;32m--> 536\u001b[0m \u001b[43mreload_module\u001b[49m\u001b[43m(\u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m \n\u001b[1;32m 537\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m:\n\u001b[1;32m 538\u001b[0m \u001b[38;5;66;03m# Loading failed. We reset our lazy state.\u001b[39;00m\n\u001b[1;32m 539\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mFailed to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m. Resetting...\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 540\u001b[0m \u001b[38;5;241m.\u001b[39mformat(modname))\n", + "File \u001b[0;32m/usr/lib/python3.10/importlib/__init__.py:169\u001b[0m, in \u001b[0;36mreload\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 167\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m spec \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[1;32m 168\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mModuleNotFoundError\u001b[39;00m(\u001b[38;5;124mf\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mspec not found for the module \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mname\u001b[38;5;132;01m!r}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m, name\u001b[38;5;241m=\u001b[39mname)\n\u001b[0;32m--> 169\u001b[0m \u001b[43m_bootstrap\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_exec\u001b[49m\u001b[43m(\u001b[49m\u001b[43mspec\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 170\u001b[0m \u001b[38;5;66;03m# The module may have replaced itself in sys.modules!\u001b[39;00m\n\u001b[1;32m 171\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m sys\u001b[38;5;241m.\u001b[39mmodules[name]\n", + "File \u001b[0;32m:619\u001b[0m, in \u001b[0;36m_exec\u001b[0;34m(spec, module)\u001b[0m\n", + "File \u001b[0;32m:883\u001b[0m, in \u001b[0;36mexec_module\u001b[0;34m(self, module)\u001b[0m\n", + "File \u001b[0;32m:241\u001b[0m, in \u001b[0;36m_call_with_frames_removed\u001b[0;34m(f, *args, **kwds)\u001b[0m\n", + "File \u001b[0;32m~/networkcommons/networkcommons/methods.py:1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", + "File \u001b[0;32m~/networkcommons/networkcommons/_methods/__init__.py:21\u001b[0m\n\u001b[1;32m 16\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 17\u001b[0m \u001b[38;5;124;03mNetwork based inference methods and network operations.\u001b[39;00m\n\u001b[1;32m 18\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 20\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mgraph\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[0;32m---> 21\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mcausal\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[1;32m 22\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mmoon\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", + "\u001b[0;31mAttributeError\u001b[0m: module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'" ] } ], + "source": [ + "corneto_graph = nc.methods.causal.to_cornetograph(graph)" + ] + }, + { + "cell_type": "code", + "execution_count": 40, + "metadata": {}, + "outputs": [], + "source": [ + "G = corneto_graph_to_networkx(cornetoG, skip_unsupported_edges=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 41, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'__edge_type': 'directed',\n", + " 'sign': -1,\n", + " '__source_attr': {'CALM1': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}}" + ] + }, + "execution_count": 41, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "networkxG.get_edge_data('CALM1', 'TRPC1')" + ] + }, + { + "cell_type": "code", + "execution_count": 43, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "13172" + ] + }, + "execution_count": 43, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "len(networkxG.edges())" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "[{'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CALM1': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CALM3': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CALM2': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CAV1': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'MDFI': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'ITPR2': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'STIM1': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'TRPC3': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC3': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'TRPC4': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC4': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'TRPC5': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC5': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'TRPC6': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'PKD2': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'PKD2': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'TRPV4': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPV4': {'__value': {}}},\n", + " '__target_attr': {'TRPC1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TRPC1': {'__value': {}}},\n", + " '__target_attr': {'TRPV6': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CALM1': {'__value': {}}},\n", + " '__target_attr': {'TRPC3': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " 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'interaction': -1,\n", + " '__source_attr': {'TP53': {'__value': {}}},\n", + " '__target_attr': {'TNFRSF10C': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'MAX_MYC_ZMIZ1': {'__value': {}}},\n", + " '__target_attr': {'CDKN2B': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TP53': {'__value': {}}},\n", + " '__target_attr': {'TNFRSF10A': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TP53': {'__value': {}}},\n", + " '__target_attr': {'TGFA': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1': {'__value': {}}},\n", + " '__target_attr': {'TP53': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TP53': {'__value': {}}},\n", + " '__target_attr': {'TAP1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'AXIN1': {'__value': {}}},\n", + " '__target_attr': {'MYC': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'GSK3B': {'__value': {}}},\n", + " '__target_attr': {'MYC': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'PPP2CA_PPP2R5A_PTPA': {'__value': {}}},\n", + " '__target_attr': {'MYC': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'MAX_MYC': {'__value': {}}},\n", + " '__target_attr': {'NBN': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'MIR22HG': {'__value': {}}},\n", + " '__target_attr': {'BMP7': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'MIR22HG': {'__value': {}}},\n", + " '__target_attr': {'PPARA': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'IKBKG': {'__value': {}}},\n", + " '__target_attr': {'IKBKB': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CHEK1': {'__value': {}}},\n", + " '__target_attr': {'CDC25A': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'RPS6KA5': {'__value': {}}},\n", + " '__target_attr': {'H2AZ1': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'TAF1': {'__value': {}}},\n", + " '__target_attr': {'BCL2L11': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CREBBP': {'__value': {}}},\n", + " '__target_attr': {'ASAH2B': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'KAT7': {'__value': {}}},\n", + " '__target_attr': {'H4C2': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'KAT7': {'__value': {}}},\n", + " '__target_attr': {'H3C12': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CASP8': {'__value': {}}},\n", + " '__target_attr': {'CASP6': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'GTF3C4': {'__value': {}}},\n", + " '__target_attr': {'H3C12': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'CSNK2A1_CSNK2B': {'__value': {}}},\n", + " '__target_attr': {'TOP2A': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'NCOA1': {'__value': {}}},\n", + " '__target_attr': {'H4C2': {'__value': {}}}},\n", + " {'__edge_type': 'directed',\n", + " 'interaction': -1,\n", + " '__source_attr': {'NCOA1': {'__value': {}}},\n", + " '__target_attr': {'H3C12': {'__value': {}}}},\n", + " ...]" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "G.get_attr_edges()" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "metadata": {}, + "outputs": [], "source": [ "G = cn.Graph.from_sif(\"network.csv\", delimiter=\",\", has_header=True, column_order=[0,2,1])\n", - "corneto_network = nc.run_corneto_carnival(G, sources, measurements, betaWeight=0.01)" + "# corneto_network = nc.methods.causal.run_corneto_carnival(G, sources, measurements, betaWeight=0.01)" ] }, + { + "cell_type": "code", + "execution_count": null, + "metadata": {}, + "outputs": [], + "source": [] + }, { "cell_type": "code", "execution_count": 13, @@ -5398,7 +9405,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.10.14" + "version": "3.10.12" } }, "nbformat": 4, diff --git a/networkcommons/methods/_causal.py b/networkcommons/methods/_causal.py index 48be9d9..c8f4edf 100644 --- a/networkcommons/methods/_causal.py +++ b/networkcommons/methods/_causal.py @@ -20,7 +20,8 @@ from __future__ import annotations __all__ = [ - 'convert_cornetograph', + 'to_cornetograph', + 'to_networkx', 'run_corneto_carnival', ] @@ -30,7 +31,7 @@ cn_nx = lazy_import.lazy_module('corneto.contrib.networkx') -def convert_cornetograph(graph): +def to_cornetograph(graph): """ Convert a networkx graph to a corneto graph, if needed. @@ -43,11 +44,38 @@ def convert_cornetograph(graph): if isinstance(graph, cn._graph.Graph): corneto_graph = graph elif isinstance(graph, (nx.Graph, nx.DiGraph)): - corneto_graph = cn_nx.networkx_to_corneto_graph(graph) + # substitute 'sign' for 'interaction' in the graph + for u, v, data in graph.edges(data=True): + data['interaction'] = data.pop('sign') + + corneto_graph = networkx_to_corneto_graph(graph) return corneto_graph +def to_networkx(graph, skip_unsupported_edges=True): + """ + Convert a corneto graph to a networkx graph, if needed. + + Args: + graph (cn.Graph): The corneto graph. + + Returns: + nx.Graph: The networkx graph. + """ + if isinstance(graph, nx.Graph) or isinstance(graph, nx.DiGraph): + networkx_graph = graph + elif isinstance(graph, cn._graph.Graph): + networkx_graph = corneto_graph_to_networkx( + graph, + skip_unsupported_edges=skip_unsupported_edges) + # rename interaction for sign + for u, v, data in networkx_graph.edges(data=True): + data['sign'] = data.pop('interaction') + + return networkx_graph + + def run_corneto_carnival(network, source_dict, target_dict, @@ -68,7 +96,7 @@ def run_corneto_carnival(network, nx.Graph: The subnetwork containing the paths found by CARNIVAL. list: A list containing the paths found by CARNIVAL. """ - corneto_net = convert_cornetograph(network) + corneto_net = to_cornetograph(network) problem, graph = cn.methods.runVanillaCarnival( perturbations=source_dict, @@ -83,10 +111,7 @@ def run_corneto_carnival(network, cn.methods.carnival.get_selected_edges(problem, graph), ) - network_nx = cn_nx.corneto_graph_to_networkx( - network_sol, - skip_unsupported_edges=True, - ) + network_nx = to_networkx(network_sol, skip_unsupported_edges=True) network_nx.remove_nodes_from(['_s', '_pert_c0', '_meas_c0'])