diff --git a/CMakeLists.txt b/CMakeLists.txt
index 7b896b420..5bddc9553 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -118,8 +118,6 @@ elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "(ppc|powerpc)")
 elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "s390x")
     set(ARCH "s390x")
     set(ARCH_S390X ON)
-    # CROSS not supported on big-endian (https://github.com/open-quantum-safe/liboqs/issues/1961)
-    set(OQS_ENABLE_SIG_CROSS OFF)
     if(${OQS_DIST_BUILD})
         set(OQS_DIST_S390X_BUILD ON)
     endif()