diff --git a/ChangeLog b/ChangeLog
index 11b85324e2..82b868c313 100644
--- a/ChangeLog
+++ b/ChangeLog
@@ -30,6 +30,11 @@ Release date: TBA
 
   Closes #6028
 
+* Fix crash in ``super-init-not-called`` checker when using ``ctypes.Union``.
+
+  Closes #6027
+
+
 * Fix crash for ``unneccessary-ellipsis`` checker when an ellipsis is used inside of a container or a lambda expression.
 
   Closes #6036
diff --git a/pylint/checkers/classes/class_checker.py b/pylint/checkers/classes/class_checker.py
index f5efc4dc7c..a426b99601 100644
--- a/pylint/checkers/classes/class_checker.py
+++ b/pylint/checkers/classes/class_checker.py
@@ -1999,11 +1999,12 @@ def _check_init(self, node: nodes.FunctionDef, klass_node: nodes.ClassDef) -> No
 
             # Return if any of the klass' first-order bases is protocol
             for base in klass.bases:
-                # We don't need to catch InferenceError here as _ancestors_to_call
-                # already does this for us.
-                for inf_base in base.infer():
-                    if inf_base.qname() in utils.TYPING_PROTOCOLS:
-                        return
+                try:
+                    for inf_base in base.infer():
+                        if inf_base.qname() in utils.TYPING_PROTOCOLS:
+                            return
+                except astroid.InferenceError:
+                    continue
 
             if decorated_with(node, ["typing.overload"]):
                 continue
diff --git a/tests/functional/s/super/super_init_not_called.py b/tests/functional/s/super/super_init_not_called.py
index c8e9f09d1e..90a884b0b0 100644
--- a/tests/functional/s/super/super_init_not_called.py
+++ b/tests/functional/s/super/super_init_not_called.py
@@ -48,3 +48,10 @@ def __init__(self):
 class ChildThree(ParentWithoutInit):
     def __init__(self):  # [super-init-not-called]
         ...
+
+
+# Regression test as reported in
+# https://github.com/PyCQA/pylint/issues/6027
+class MyUnion(ctypes.Union):
+    def __init__(self):  # [super-init-not-called]
+        pass
diff --git a/tests/functional/s/super/super_init_not_called.txt b/tests/functional/s/super/super_init_not_called.txt
index 615b24a542..aafaa2023c 100644
--- a/tests/functional/s/super/super_init_not_called.txt
+++ b/tests/functional/s/super/super_init_not_called.txt
@@ -1,2 +1,3 @@
 undefined-variable:18:23:18:40:UninferableChild:Undefined variable 'UninferableParent':UNDEFINED
 super-init-not-called:49:4:49:16:ChildThree.__init__:__init__ method from base class 'ParentWithoutInit' is not called:INFERENCE
+super-init-not-called:56:4:56:16:MyUnion.__init__:__init__ method from base class 'Union' is not called:INFERENCE