From 9f85e7d369bf50ac84dfbdee95cff43c0b79c152 Mon Sep 17 00:00:00 2001 From: walzer Date: Tue, 17 Oct 2017 14:36:03 +0100 Subject: [PATCH] added PSI-MOD contents from sourceforge cvs for fixing links and future reference to a dedicated repository. --- AtomTabl.DTD | 45 + AtomTabl.XML | 2557 + PSI-MOD.obo | 38525 ++++++++++++ PSI-MOD.obo.xml | 149703 +++++++++++++++++++++++++++++++++++++++++++++ README.md | 12 +- 5 files changed, 190841 insertions(+), 1 deletion(-) create mode 100644 AtomTabl.DTD create mode 100644 AtomTabl.XML create mode 100644 PSI-MOD.obo create mode 100644 PSI-MOD.obo.xml diff --git a/AtomTabl.DTD b/AtomTabl.DTD new file mode 100644 index 0000000..b6f2c06 --- /dev/null +++ b/AtomTabl.DTD @@ -0,0 +1,45 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + diff --git a/AtomTabl.XML b/AtomTabl.XML new file mode 100644 index 0000000..c827012 --- /dev/null +++ b/AtomTabl.XML @@ -0,0 +1,2557 @@ + + + + + + + +03.00 +2013-30-31 + + 0 + electron + e + 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+ 0.2183 + + + 173 + (173)Yb + 172.938210787(2563) + 0.1613 + + + 174 + (174)Yb + 173.938862089(2563) + 0.3183 + + + 176 + (176)Yb + 175.942571683(2760) + 0.1276 + + + + 71 + lutetium + Lu + 174.9668(1) + + 175 + (175)Lu + 174.940771819(2347) + 0.9741 + + + 176 + (176)Lu + 175.942686310(2344) + 0.0259 + + + + 72 + hafnium + Hf + 178.49(2) + + 174 + (174)Hf + 173.940046178(3012) + 0.0016 + + + 176 + (176)Hf + 175.941408631(2379) + 0.0526 + + + 177 + (177)Hf + 176.943220651(2304) + 0.1860 + + + 178 + (178)Hf + 177.943698766(2301) + 0.2728 + + + 179 + (179)Hf + 178.945816145(2301) + 0.1362 + + + 180 + (180)Hf + 179.946549953(2304) + 0.3508 + + + + 73 + tantalum + Ta + 180.94788(2) + + 180 + (180)Ta + 179.947464831(2379) + 0.00012 + + + 181 + (181)Ta + 180.947995763(1924) + 0.99988 + + + + 74 + tungsten + W + 183.84(1) + + 180 + (180)W + 179.946704459(4219) + 0.0012 + + + 182 + (182)W + 181.948204156(889) + 0.2650 + + + 183 + (183)W + 182.950222951(884) + 0.1431 + + + 184 + (184)W + 183.950931188(922) + 0.3064 + + + 186 + (186)W + 185.954364127(1877) + 0.2843 + + + + 75 + rhenium + Re + 186.207(1) + + 185 + (185)Re + 184.952954982(1280) + 0.3740 + + + 187 + (187)Re + 186.955753109(1513) + 0.6260 + + + + 76 + osmium + Os + 190.23(3) + + 184 + (184)Os + 183.952489071(1399) + 0.0002 + + + 186 + (186)Os + 185.953838158(1481) + 0.0159 + + + 187 + (187)Os + 186.955750458(1513) + 0.0196 + + + 188 + (188)Os + 187.955838228(1518) + 0.1324 + + + 189 + (189)Os + 188.958147470(1572) + 0.1615 + + + 190 + (190)Os + 189.958447048(1580) + 0.2626 + + + 192 + (192)Os + 191.961480690(2743) + 0.4078 + + + + 77 + iridium + Ir + 192.217(3) + + 191 + (191)Ir + 190.960594046(1790) + 0.373 + + + 193 + (193)Ir + 192.962926430(1795) + 0.627 + + + + 78 + platinum + Pt + 195.084(9) + + 190 + (190)Pt + 189.959931655(6124) + 0.00014 + + + 192 + (192)Pt + 191.961038005(2651) + 0.00782 + + + 194 + (194)Pt + 193.962680253(948) + 0.32967 + + + 195 + (195)Pt + 194.964791134(940) + 0.33832 + + + 196 + (196)Pt + 195.964951521(931) + 0.25242 + + + 198 + (198)Pt + 197.967892790(3341) + 0.07163 + + + + 79 + gold + Au + 196.966569(4) + + 197 + (197)Au + 196.966568662(646) + 1.0000 + + + + 80 + mercury + Hg + 200.592(3) + + 196 + (196)Hg + 195.965832649(3158) + 0.0015 + + + 198 + (198)Hg + 197.966769032(362) + 0.0997 + + + 199 + (199)Hg + 198.968279932(392) + 0.1687 + + + 200 + (200)Hg + 199.968326004(406) + 0.2310 + + + 201 + (201)Hg + 200.970302268(638) + 0.1318 + + + 202 + (202)Hg + 201.970643011(634) + 0.2986 + + + 204 + (204)Hg + 203.973493933(364) + 0.0687 + + + + 81 + thallium + Tl + 204.38 + [204.382; 204.385] + + 203 + (203)Tl + 202.972344220(1365) + 0.2952 + + + 205 + (205)Tl + 204.974427541(1422) + 0.7048 + + + + 82 + lead + Pb + 207.2(1) + + 204 + (204)Pb + 203.973043589(1335) + 0.014 + + + 206 + (206)Pb + 205.974465278(1331) + 0.241 + + + 207 + (207)Pb + 206.975896887(1334) + 0.221 + + + 208 + (208)Pb + 207.976652071(1335) + 0.524 + + + + 83 + bismuth + Bi + 208.98040(1) + + 209 + (209)Bi + 208.980398734(1554) + 1.0000 + + + + 84 + polonium + Po + [209] + + + 85 + astatine + At + [210] + + + 86 + radon + Rn + [222] + + + + 87 + francium + Fr + [223] + + + 88 + radium + Ra + [226] + + + 89 + actinium + Ac + [227] + + + 90 + thorium + Th + 232.03806(2) + + 232 + (232)Th + 232.038055325(2137) + 1.0000 + + + + 91 + protactinium + Pa + 231.03588(2) + + 231 + (231)Pa + 231.035883990(2422) + 1.0000 + + + + 92 + uranium + U + 238.02891(3) + + 234 + (234)U + 234.040952088(1960) + 0.000054 + + + 235 + (235)U + 235.043929918(1957) + 0.007204 + + + 238 + (238)U + 238.050788247(2044) + 0.992742 + + + + 93 + neptunium + Np + [237] + + + 94 + plutonium + Pu + [244] + + + 95 + americium + Am + [243] + + + 96 + curium + Cm + [247] + + + 97 + berkelium + Bk + [247] + + + 98 + californium + Cf + [251] + + + 99 + einsteinium + Es + [252] + + + 100 + fermium + Fm + [257] + + + 101 + mendelevium + Md + [258] + + + 102 + nobelium + No + [259] + + + 103 + lawrencium + Lr + [262] + + + 104 + rutherfordium + Rf + [267] + + + 105 + dubnium + Db + [268] + + + 106 + seaborgium + Sg + [271] + + + 107 + bohrium + Bh + [272] + + + 108 + hassium + Hs + [270] + + + 109 + meitnerium + Mt + [276] + + + 110 + darmstadtium + Ds + [281] + + + 111 + roentgenium + Rg + [280] + + + 112 + copernicium + Cn + [285] + + + 113 + ununtrium + Uut + [284] + + + 114 + ununquadium + Uuq + [289] + + + 115 + ununpentium + Uup + [288] + + + 116 + ununhexium + Uuh + [293] + + + 118 + ununoctium + Uuo + [294] + + diff --git a/PSI-MOD.obo b/PSI-MOD.obo new file mode 100644 index 0000000..79815ea --- /dev/null +++ b/PSI-MOD.obo @@ -0,0 +1,38525 @@ +format-version: 1.2 +date: 30:05:2014 00:48 +saved-by: John S. Garavelli +auto-generated-by: FormulaOBO.PL +subsetdef: PSI-MOD-slim "subset of protein modifications" +synonymtypedef: DeltaMass-label "Label from MS DeltaMass" EXACT +synonymtypedef: OMSSA-label "Short label from OMSSA" EXACT +synonymtypedef: PSI-MOD-alternate "Alternate name curated by PSI-MOD" EXACT +synonymtypedef: PSI-MOD-label "Short label curated by PSI-MOD" EXACT +synonymtypedef: PSI-MS-label "Agreed label from MS community" RELATED +synonymtypedef: RESID-alternate "Alternate name from RESID" EXACT +synonymtypedef: RESID-misnomer "Misnomer tagged alternate name from RESID" RELATED +synonymtypedef: RESID-name "Name from RESID" EXACT +synonymtypedef: RESID-systematic "Systematic name from RESID" EXACT +synonymtypedef: UniMod-alternate "Alternate name from UniMod" RELATED +synonymtypedef: UniMod-description "Description (full_name) from UniMod" RELATED +synonymtypedef: UniMod-interim "Interim label from UniMod" RELATED +synonymtypedef: UniProt-feature "Protein feature description from UniProtKB" EXACT +default-namespace: PSI-MOD +remark: PSI-MOD version: 1.013.0 +remark: RESID release: 75.00 +remark: ISO-8601 date: 2014-01-28 14:22Z +remark: Annotation note 1 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. +remark: Annotation note 2 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". +remark: Annotation note 3 - When an entry in the UniMod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the UniMod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". +remark: Annotation note 4 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. +remark: Annotation note 5 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. +remark: Annotation note 6 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. +remark: Annotation note 7 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". +remark: Annotation note 8 - The DeltaMass listings for free amino acids have been removed. Most UniMod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. +remark: Annotation note 9 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references. + +[Term] +id: MOD:00000 +name: protein modification +def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModRes" EXACT PSI-MOD-label [] + +[Term] +id: MOD:00001 +name: alkylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an alkyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "AlkylRes" EXACT PSI-MOD-label [] +xref: Source: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00002 +name: O-glycosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-glycosylserine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OGlycoSer" EXACT PSI-MOD-label [] +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00396 ! O-glycosylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00003 +name: UniMod +def: "Entry from UniMod." [PubMed:18688235] +comment: This term is for organizational use only and should not be assigned. [JSG] +xref: Source: "none" +is_a: MOD:00032 ! uncategorized protein modification + +[Term] +id: MOD:00004 +name: artifact +def: "Artifact entry from UniMod - OBSOLETE because organizational use is no longer required." [PubMed:18688235] +is_obsolete: true + +[Term] +id: MOD:00005 +name: O-glycosyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OGlycoThr" EXACT PSI-MOD-label [] +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00396 ! O-glycosylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00006 +name: N-glycosylated residue +def: "A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NGlycoRes" EXACT PSI-MOD-label [] +xref: Source: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00007 +name: selenium substitution for sulfur +def: "A protein modification that effectively substitutes a selenium atom for a sulfur atom." [PubMed:12148805, UniMod:162] +synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] +synonym: "Se(S)Res" EXACT PSI-MOD-label [] +synonym: "Selenium replaces sulphur" RELATED UniMod-description [] +xref: DiffAvg: "46.91" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S -1 Se 1" +xref: DiffMono: "47.944450" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00745 ! selenium containing residue + +[Term] +id: MOD:00008 +name: common +def: "Entry from UniMod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required." [PubMed:18688235] +is_obsolete: true + +[Term] +id: MOD:00009 +name: natural residue +def: "A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue." [PubMed:6692818, RESID:AA0000] +subset: PSI-MOD-slim +synonym: "alpha-amino acid" EXACT RESID-name [] +synonym: "Res" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "natural" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00010 +name: L-alanine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-alanine." [ChEBI:29948, DeltaMass:0, PubMed:6692818, RESID:AA0001] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "2-aminopropionic acid" EXACT RESID-alternate [] +synonym: "2-azanylpropanoic acid" EXACT RESID-alternate [] +synonym: "Ala" EXACT PSI-MOD-label [] +synonym: "alpha-alanine" EXACT RESID-alternate [] +synonym: "alpha-aminopropionic acid" EXACT RESID-alternate [] +synonym: "L-alanine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00570 ! residues isobaric at 71.037114 Da +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00011 +name: L-arginine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-arginine." [ChEBI:29952, DeltaMass:0, PubMed:518876, PubMed:6692818, RESID:AA0002] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-5-(carbamimidamido)pentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-5-guanidinopentanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-5-guanidinovaleric acid" EXACT RESID-alternate [] +synonym: "2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-delta-guanidinovaleric acid" EXACT RESID-alternate [] +synonym: "Arg" EXACT PSI-MOD-label [] +synonym: "L-arginine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 12 N 4 O 1" +xref: MassAvg: "156.19" +xref: MassMono: "156.101111" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00012 +name: L-asparagine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-asparagine." [ChEBI:29956, DeltaMass:0, PubMed:15736973, PubMed:5681232, PubMed:6692818, PubMed:9789001, RESID:AA0003] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-butanediamic acid" EXACT RESID-systematic [] +synonym: "2,4-bis(azanyl)-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "2,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-carbamoylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-4-butanediamic acid" EXACT RESID-alternate [] +synonym: "2-aminosuccinamic acid" EXACT RESID-alternate [] +synonym: "2-aminosuccinic acid 4-amide" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-carbamylpropionic acid" EXACT RESID-alternate [] +synonym: "alpha-aminosuccinamic acid" EXACT RESID-alternate [] +synonym: "Asn" EXACT PSI-MOD-label [] +synonym: "aspartic acid 4-amide" EXACT RESID-alternate [] +synonym: "aspartic acid beta-amide" EXACT RESID-alternate [] +synonym: "beta-asparagine" EXACT RESID-alternate [] +synonym: "L-asparagine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 4 H 6 N 2 O 2" +xref: MassAvg: "114.10" +xref: MassMono: "114.042927" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00013 +name: L-aspartic acid residue +def: "A protein modification that effectively converts a source amino acid residue to an L-aspartic acid." [ChEBI:29958, DeltaMass:0, PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, RESID:AA0004] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminobutanedioic acid" EXACT RESID-systematic [] +synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] +synonym: "aminosuccinic acid" EXACT RESID-alternate [] +synonym: "Asp" EXACT PSI-MOD-label [] +synonym: "L-aspartic acid" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00014 +name: L-cysteine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-cysteine." [ChEBI:29950, DeltaMass:0, PubMed:1310545, PubMed:15790858, PubMed:3447159, PubMed:6692818, PubMed:7338899, RESID:AA0005] +comment: From DeltaMass: Average Mass: 121. +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "(R)-cysteine" EXACT RESID-alternate [] +synonym: "2-amino-3-mercaptopropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-mercaptopropionic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "3-mercapto-L-alanine" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-mercaptopropanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-mercaptopropionic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-thiolpropionic acid" EXACT RESID-alternate [] +synonym: "beta-mercaptoalanine" EXACT RESID-alternate [] +synonym: "Cys" EXACT PSI-MOD-label [] +synonym: "Cysteine (C, Cys)" EXACT DeltaMass-label [] +synonym: "half-cystine" EXACT RESID-alternate [] +synonym: "L-(+)-cysteine" EXACT RESID-alternate [] +synonym: "L-cysteine" EXACT RESID-name [] +synonym: "thioserine" EXACT RESID-alternate [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 3 H 5 N 1 O 1 S 1" +xref: MassAvg: "103.14" +xref: MassMono: "103.009185" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00015 +name: L-glutamic acid residue +def: "A protein modification that effectively converts a source amino acid residue to an L-glutamic acid." [ChEBI:29972, DeltaMass:0, PubMed:1881881, PubMed:4565668, PubMed:4922541, PubMed:6692818, PubMed:9326660, PubMed:957425, RESID:AA0006] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminopentanedioic acid" EXACT RESID-systematic [] +synonym: "1-aminopropane-1,3-dicarboxylic acid" EXACT RESID-alternate [] +synonym: "2-aminoglutaric acid" EXACT RESID-alternate [] +synonym: "2-azanylpentanedioic acid" EXACT RESID-alternate [] +synonym: "alpha-aminoglutaric acid" EXACT RESID-alternate [] +synonym: "Glu" EXACT PSI-MOD-label [] +synonym: "glutaminic acid" EXACT RESID-alternate [] +synonym: "L-glutamic acid" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00016 +name: L-glutamine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-glutamine." [ChEBI:30011, DeltaMass:0, PubMed:3340166, PubMed:6692818, PubMed:9342308, RESID:AA0007] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-pentanediamic acid" EXACT RESID-systematic [] +synonym: "2,5-bis(azanyl)-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "2,5-diamino-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-4-carbamoylbutanoic acid" EXACT RESID-alternate [] +synonym: "2-aminoglutaramic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-gamma-carbamylbutyric acid" EXACT RESID-alternate [] +synonym: "Gln" EXACT PSI-MOD-label [] +synonym: "glutamic acid 5-amide" EXACT RESID-alternate [] +synonym: "glutamic acid gamma-amide" EXACT RESID-alternate [] +synonym: "glutamide" EXACT RESID-alternate [] +synonym: "L-glutamine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 8 N 2 O 2" +xref: MassAvg: "128.13" +xref: MassMono: "128.058578" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00894 ! residues isobaric at 128.058578 Da +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00017 +name: glycine residue +def: "A protein modification that effectively converts a source amino acid residue to a glycine." [ChEBI:29947, DeltaMass:0, PubMed:1310545, PubMed:6692818, RESID:AA0008] +subset: PSI-MOD-slim +synonym: "aminoacetic acid" EXACT RESID-alternate [] +synonym: "aminoethanoic acid" EXACT RESID-systematic [] +synonym: "azanylethanoic acid" EXACT RESID-alternate [] +synonym: "Gly" EXACT PSI-MOD-label [] +synonym: "glycine" EXACT RESID-name [] +synonym: "glycocoll" EXACT RESID-alternate [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 2 H 3 N 1 O 1" +xref: MassAvg: "57.05" +xref: MassMono: "57.021464" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00018 +name: L-histidine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-histidine." [ChEBI:29979, DeltaMass:0, PubMed:14342316, PubMed:2722967, PubMed:512, PubMed:5460889, PubMed:6129252, PubMed:6692818, PubMed:6876174, RESID:AA0009] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "4-(2-amino-2-carboxyethyl)imidazole" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-(4-imidazole)propionic acid" EXACT RESID-alternate [] +synonym: "glyoxaline-5-alanine" EXACT RESID-alternate [] +synonym: "His" EXACT PSI-MOD-label [] +synonym: "L-histidine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 7 N 3 O 1" +xref: MassAvg: "137.14" +xref: MassMono: "137.058912" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00019 +name: L-isoleucine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-isoleucine." [ChEBI:30009, DeltaMass:0, PubMed:6692818, RESID:AA0010] +subset: PSI-MOD-slim +synonym: "(2S,3S)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "3-methyl-norvaline" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate [] +synonym: "Ile" EXACT PSI-MOD-label [] +synonym: "Isoleucyl" EXACT DeltaMass-label [] +synonym: "L-erythro-isoleucine" EXACT RESID-alternate [] +synonym: "L-isoleucine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00306 ! residues isobaric at 113.084064 Da +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00020 +name: L-leucine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-leucine." [ChEBI:30006, DeltaMass:0, PubMed:11478885, PubMed:6692818, RESID:AA0011] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-4-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "4-methyl-norvaline" EXACT RESID-alternate [] +synonym: "alpha-amino-gamma-methylvaleric acid" EXACT RESID-alternate [] +synonym: "alpha-aminoisocaproic acid" EXACT RESID-alternate [] +synonym: "L-leucine" EXACT RESID-name [] +synonym: "Leu" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00306 ! residues isobaric at 113.084064 Da +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00021 +name: L-lysine residue +def: "A protein modification that effectively converts a source amino acid residue to L-lysine." [ChEBI:29967, DeltaMass:0, PubMed:3106962, PubMed:6120171, PubMed:6692818, RESID:AA0012] +subset: PSI-MOD-slim +synonym: "(2S)-2,6-diaminohexanoic acid" EXACT RESID-systematic [] +synonym: "2,6-bis(azanyl)hexanoic acid" EXACT RESID-alternate [] +synonym: "6-amino-L-norleucine" EXACT RESID-alternate [] +synonym: "ACT_SITE Schiff-base intermediate with substrate" EXACT UniProt-feature [] +synonym: "alpha,epsilon-diaminocaproic acid" EXACT RESID-alternate [] +synonym: "L-lysine" EXACT RESID-name [] +synonym: "Lys" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 12 N 2 O 1" +xref: MassAvg: "128.18" +xref: MassMono: "128.094963" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00893 ! residues isobaric at 128.0-128.1 +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00022 +name: L-methionine residue +def: "A protein modification that effectively converts a source amino acid residue to L-methionine." [ChEBI:29983, DeltaMass:0, PubMed:6411710, PubMed:6692818, RESID:AA0013] +comment: From DeltaMass: Average Mass: 149 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-4-(methylthio)butyric acid" EXACT RESID-alternate [] +synonym: "2-azanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-gamma-methylmercaptobutyric acid" EXACT RESID-alternate [] +synonym: "alpha-amino-gamma-methylthiobutyric acid" EXACT RESID-alternate [] +synonym: "gamma-methylthio-alpha-aminobutyric acid" EXACT RESID-alternate [] +synonym: "L-(-)-methionine" EXACT RESID-alternate [] +synonym: "L-methionine" EXACT RESID-name [] +synonym: "Met" EXACT PSI-MOD-label [] +synonym: "S-methyl-L-homocysteine" EXACT RESID-alternate [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "131.19" +xref: MassMono: "131.040485" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00023 +name: L-phenylalanine residue +def: "A protein modification that effectively converts a source amino acid residue to L-phenylalanine." [ChEBI:29997, DeltaMass:0, PubMed:6692818, RESID:AA0014] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-phenylpropanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-phenylpropionic acid" EXACT RESID-alternate [] +synonym: "L-phenylalanine" EXACT RESID-name [] +synonym: "Phe" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 9 H 9 N 1 O 1" +xref: MassAvg: "147.18" +xref: MassMono: "147.068414" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00024 +name: L-proline residue +def: "A protein modification that effectively converts a source amino acid residue to L-proline." [ChEBI:30017, DeltaMass:0, PubMed:6692818, PubMed:8547259, RESID:AA0015] +subset: PSI-MOD-slim +synonym: "(2S)-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] +synonym: "L-proline" EXACT RESID-name [] +synonym: "Pro" EXACT PSI-MOD-label [] +synonym: "pyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 7 N 1 O 1" +xref: MassAvg: "97.12" +xref: MassMono: "97.052764" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00025 +name: L-serine residue +def: "A protein modification that effectively converts a source amino acid residue to L-serine." [ChEBI:29999, DeltaMass:0, PubMed:4399050, PubMed:6692818, RESID:AA0016] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-hydroxypropanoic acid" EXACT RESID-alternate [] +synonym: "3-hydroxy-L-alanine" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-hydroxypropionic acid" EXACT RESID-alternate [] +synonym: "beta-hydroxyalanine" EXACT RESID-alternate [] +synonym: "L-serine" EXACT RESID-name [] +synonym: "Ser" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 3 H 5 N 1 O 2" +xref: MassAvg: "87.08" +xref: MassMono: "87.032028" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00026 +name: L-threonine residue +def: "A protein modification that effectively converts a source amino acid residue to L-threonine." [ChEBI:30013, DeltaMass:0, PubMed:2989287, PubMed:6692818, RESID:AA0017] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-hydroxybutanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-hydroxybutanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-hydroxybutyric acid" EXACT RESID-alternate [] +synonym: "beta-methylserine" EXACT RESID-alternate [] +synonym: "L-threo-threonine" EXACT RESID-alternate [] +synonym: "L-threonine" EXACT RESID-name [] +synonym: "Thr" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 4 H 7 N 1 O 2" +xref: MassAvg: "101.10" +xref: MassMono: "101.047678" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00027 +name: L-tryptophan residue +def: "A protein modification that effectively converts a source amino acid residue to L-tryptophan." [ChEBI:29954, DeltaMass:0, PubMed:2059637, PubMed:6692818, PubMed:9324768, RESID:AA0018] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-(3-indolyl)propionoic acid" EXACT RESID-alternate [] +synonym: "beta(3-indolyl)alanine" EXACT RESID-alternate [] +synonym: "L-tryptophan" EXACT RESID-name [] +synonym: "Trp" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 11 H 10 N 2 O 1" +xref: MassAvg: "186.21" +xref: MassMono: "186.079313" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00028 +name: L-tyrosine residue +def: "A protein modification that effectively converts a source amino acid residue to L-tyrosine." [ChEBI:29975, DeltaMass:0, PubMed:2190093, PubMed:2542938, PubMed:5550972, PubMed:6061414, PubMed:6120171, PubMed:6692818, RESID:AA0019] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-(para-hydroxyphenyl)propionic acid" EXACT RESID-alternate [] +synonym: "L-tyrosine" EXACT RESID-name [] +synonym: "p-tyrosine" EXACT RESID-alternate [] +synonym: "para-hydroxyphenylalanine" EXACT RESID-alternate [] +synonym: "Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 9 H 9 N 1 O 2" +xref: MassAvg: "163.18" +xref: MassMono: "163.063329" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00029 +name: L-valine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-valine." [ChEBI:30015, DeltaMass:0, PubMed:6692818, RESID:AA0020] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-methylbutanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-methylbutyric acid" EXACT RESID-alternate [] +synonym: "alpha-aminoisovaleric acid" EXACT RESID-alternate [] +synonym: "L-valine" EXACT RESID-name [] +synonym: "Val" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 9 N 1 O 1" +xref: MassAvg: "99.13" +xref: MassMono: "99.068414" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01441 ! natural, standard, encoded residue + +[Term] +id: MOD:00030 +name: N-formyl-L-methionine residue +def: "A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification." [ChEBI:33718, OMSSA:22, PubMed:10825024, PubMed:11152118, PubMed:2165784, PubMed:3042771, PubMed:8758896, RESID:AA0021#FMET, UniMod:107#N-term] +subset: PSI-MOD-slim +synonym: "(2S)-2-formylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-formamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "2-formylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "2-formylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "Addition of N-formyl met" RELATED UniMod-description [] +synonym: "fMet" EXACT PSI-MOD-label [] +synonym: "FormylMet" RELATED PSI-MS-label [] +synonym: "MOD_RES N-formylmethionine" EXACT UniProt-feature [] +synonym: "N-formyl-L-methionine" EXACT RESID-name [] +synonym: "N-formylated L-methionine" EXACT PSI-MOD-alternate [] +synonym: "nformylmet" EXACT OMSSA-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 10 N 1 O 2 S 1" +xref: MassAvg: "160.21" +xref: MassMono: "160.043225" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:00868 ! natural, non-standard encoded residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00031 +name: L-selenocysteine residue +def: "A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification." [ChEBI:30000, PubMed:10523135, PubMed:1066676, PubMed:2037562, PubMed:2963330, PubMed:4734725, PubMed:6076213, PubMed:6217842, PubMed:6714945, RESID:AA0022] +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-selanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-selanylpropanoic acid" EXACT RESID-alternate [] +synonym: "3-selenylalanine" EXACT RESID-alternate [] +synonym: "L-selenocysteine" EXACT RESID-name [] +synonym: "NON_STD Selenocysteine" EXACT UniProt-feature [] +synonym: "Sec" EXACT PSI-MOD-label [] +synonym: "SeCys" EXACT RESID-alternate [] +synonym: "selenium cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0 Se 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 3 H 5 N 1 O 1 Se 1" +xref: MassAvg: "150.05" +xref: MassMono: "150.953635" +xref: Origin: "U" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00745 ! selenium containing residue +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00868 ! natural, non-standard encoded residue + +[Term] +id: MOD:00032 +name: uncategorized protein modification +def: "A protein modification that is not chemically categorized." [PubMed:18688235] +comment: This term is for organizational use only and should not be assigned. [JSG] +xref: Source: "none" +is_a: MOD:00000 ! protein modification + +[Term] +id: MOD:00033 +name: crosslinked residues +def: "A protein modification that crosslinks two or more amino acid residues with covalent bonds." [PubMed:18688235] +comment: The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. +subset: PSI-MOD-slim +synonym: "XLNK-Res-Res" EXACT PSI-MOD-label [] +xref: Source: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00034 +name: L-cystine (cross-link) +def: "A protein modification that effectively cross-links two L-cysteine residues to form L-cystine." [ChEBI:16283, DeltaMass:0, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025#CYS2] +comment: Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. +subset: PSI-MOD-slim +synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer [] +synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate [] +synonym: "3,3'-dithiodialanine" EXACT RESID-alternate [] +synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate [] +synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate [] +synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate [] +synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate [] +synonym: "Cys2" EXACT PSI-MOD-label [] +synonym: "Cystine ((Cys)2)" EXACT DeltaMass-label [] +synonym: "dicysteine" EXACT RESID-alternate [] +synonym: "DISULFID" EXACT UniProt-feature [] +synonym: "DISULFID Interchain" EXACT UniProt-feature [] +synonym: "L-cystine" EXACT RESID-name [] +synonym: "XLNK-SCys-SCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 2 S 2" +xref: MassAvg: "204.26" +xref: MassMono: "204.002720" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00689 ! disulfide crosslinked residues + +[Term] +id: MOD:00035 +name: (2S,3R)-3-hydroxyasparagine +def: "A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine." [PubMed:11823643, PubMed:2820791, RESID:AA0026] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "(2S,3R)-2-amino-3-hydroxy-4-butanediamic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-3-hydroxyasparagine" EXACT RESID-name [] +synonym: "(3R)3HyAsn" EXACT PSI-MOD-label [] +synonym: "2-azanyl-3-hydroxy-4-butanediamic acid" EXACT RESID-alternate [] +synonym: "erythro-beta-hydroxylated L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "L-erythro-beta-hydroxyasparagine" EXACT RESID-alternate [] +synonym: "MOD_RES (3R)-3-hydroxyasparagine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 4 H 6 N 2 O 3" +xref: MassAvg: "130.10" +xref: MassMono: "130.037842" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01688 ! 3-hydroxy-L-asparagine + +[Term] +id: MOD:00036 +name: (2S,3R)-3-hydroxyaspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid." [OMSSA:59, PubMed:6572939, PubMed:6871167, PubMed:8355279, RESID:AA0027, UniMod:35#D] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-hydroxybutanedioic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-3-hydroxyaspartic acid" EXACT RESID-name [] +synonym: "(3R)3HyAsp" EXACT PSI-MOD-label [] +synonym: "2-amino-3-hydroxysuccinic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-hydroxybutanedioic acid" EXACT RESID-alternate [] +synonym: "3-hydroxyaspartic acid" EXACT RESID-alternate [] +synonym: "erythro-beta-hydroxylated L-aspartic acid" EXACT PSI-MOD-alternate [] +synonym: "hydroxylationd" EXACT OMSSA-label [] +synonym: "L-erythro-beta-hydroxyaspartic acid" EXACT RESID-alternate [] +synonym: "MOD_RES (3R)-3-hydroxyaspartate" EXACT UniProt-feature [] +synonym: "Oxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 4 H 5 N 1 O 4" +xref: MassAvg: "131.09" +xref: MassMono: "131.021858" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01926 ! 3-hydroxy-L-aspartic acid + +[Term] +id: MOD:00037 +name: 5-hydroxy-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues." [ChEBI:60175, PubMed:18688235] +subset: PSI-MOD-slim +synonym: "5-hydroxylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "5HyLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 2 O 2" +xref: MassAvg: "144.17" +xref: MassMono: "144.089878" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01047 ! monohydroxylated lysine + +[Term] +id: MOD:00038 +name: 3-hydroxy-L-proline +def: "A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline." [ChEBI:16889, PubMed:2400108, PubMed:3734192, PubMed:4343807, RESID:AA0029] +subset: PSI-MOD-slim +synonym: "(2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "3-hydroxy-L-proline" EXACT RESID-name [] +synonym: "3-hydroxylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "3-trans-hydroxy-L-proline" EXACT RESID-alternate [] +synonym: "3HyPro" EXACT PSI-MOD-label [] +synonym: "beta-hydroxypyrrolidine-alpha-carboxylic acid" EXACT RESID-alternate [] +synonym: "L-threo-3-hydroxyproline" EXACT RESID-alternate [] +synonym: "MOD_RES 3-hydroxyproline" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01024 ! monohydroxylated proline + +[Term] +id: MOD:00039 +name: 4-hydroxy-L-proline +def: "A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline" [ChEBI:18095, PubMed:11292863, PubMed:2400108, PubMed:3734192, RESID:AA0030] +subset: PSI-MOD-slim +synonym: "(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "4-hydroxy-L-proline" EXACT RESID-name [] +synonym: "4-hydroxylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "4-hydroxyproline" EXACT RESID-alternate [] +synonym: "4-trans-hydroxy-L-proline" EXACT RESID-alternate [] +synonym: "4HyPro" EXACT PSI-MOD-label [] +synonym: "gamma-hydroxypyrrolidine-alpha-carboxylic acid" EXACT RESID-alternate [] +synonym: "L-threo-4-hydroxyproline" EXACT RESID-alternate [] +synonym: "MOD_RES 4-hydroxyproline" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01024 ! monohydroxylated proline + +[Term] +id: MOD:00040 +name: 2-pyrrolidone-5-carboxylic acid (Gln) +def: "A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid." [ChEBI:30652, DeltaMass:123, OMSSA:110, PubMed:10214721, PubMed:1836357, PubMed:26343, PubMed:3473473, RESID:AA0031#GLN, UniMod:28#Q] +comment: DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 +subset: PSI-MOD-slim +synonym: "(2S)-5-oxo-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] +synonym: "2-oxopyrrolidine-5-carboxylic acid" EXACT RESID-alternate [] +synonym: "2-pyrrolidone-5-carboxylic acid" EXACT RESID-name [] +synonym: "5-oxoproline" EXACT RESID-alternate [] +synonym: "5-oxopyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] +synonym: "5-pyrrolidone-2-carboxylic acid" EXACT RESID-alternate [] +synonym: "Gln->pyro-Glu" RELATED PSI-MS-label [] +synonym: "MOD_RES Pyrrolidone carboxylic acid" EXACT UniProt-feature [] +synonym: "N-pyrrolidone carboxyl (N terminus)" EXACT DeltaMass-label [] +synonym: "ntermpeppyroq" EXACT OMSSA-label [] +synonym: "PCA" EXACT RESID-alternate [] +synonym: "PyrGlu(Gln)" EXACT PSI-MOD-label [] +synonym: "Pyro-glu from Q" RELATED UniMod-description [] +synonym: "pyroglutamic acid" EXACT RESID-alternate [] +synonym: "Pyroglutamic Acid formed from Gln" EXACT DeltaMass-label [] +synonym: "Pyroglutamyl" EXACT DeltaMass-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 5 H 6 N 1 O 2" +xref: MassAvg: "112.11" +xref: MassMono: "112.039853" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid +is_a: MOD:01160 ! deaminated residue + +[Term] +id: MOD:00041 +name: L-gamma-carboxyglutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid." [DeltaMass:217, OMSSA:48, PubMed:10517147, PubMed:1807167, PubMed:3263814, PubMed:4528109, PubMed:7457858, PubMed:8135347, PubMed:8868490, PubMed:9188685, RESID:AA0032, UniMod:299#E] +comment: DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173. +subset: PSI-MOD-slim +synonym: "(3S)-3-aminopropane-1,1,3-tricarboxylic acid" EXACT RESID-systematic [] +synonym: "(3S)-3-azanylpropane-1,1,3-tricarboxylic acid" EXACT RESID-alternate [] +synonym: "1-carboxyglutamic acid" RELATED RESID-misnomer [] +synonym: "3-amino-1,1,3-propanetricarboxylic acid" EXACT RESID-alternate [] +synonym: "3-azanylpropane-1,1,3-tricarboxylic acid" EXACT RESID-alternate [] +synonym: "4-carboxyglutamic acid" EXACT RESID-alternate [] +synonym: "4CbxGlu" EXACT PSI-MOD-label [] +synonym: "Carboxy" RELATED PSI-MS-label [] +synonym: "Carboxy" RELATED UniMod-interim [] +synonym: "Carboxy Glutamyl" EXACT DeltaMass-label [] +synonym: "Carboxylation" RELATED UniMod-description [] +synonym: "gamma-carboxylated L-glutamic acid" EXACT PSI-MOD-alternate [] +synonym: "gammacarboxyle" EXACT OMSSA-label [] +synonym: "L-gamma-carboxyglutamic acid" EXACT RESID-name [] +synonym: "MOD_RES 4-carboxyglutamate" EXACT UniProt-feature [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "C 6 H 7 N 1 O 5" +xref: MassAvg: "173.12" +xref: MassMono: "173.032422" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:00042 +name: L-aspartic 4-phosphoric anhydride +def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride." [ChEBI:15836, PubMed:4357737, RESID:AA0033, UniMod:21#D] +synonym: "(2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid" EXACT RESID-systematic [] +synonym: "2-aminobutanedioic 4-phosphoric anhydride" EXACT RESID-alternate [] +synonym: "2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid" EXACT RESID-alternate [] +synonym: "4-oxo-O-phosphono-L-homoserine" EXACT RESID-alternate [] +synonym: "4-phosphoaspartic acid" EXACT RESID-alternate [] +synonym: "4-phosphorylated L-aspartatic acid" EXACT PSI-MOD-alternate [] +synonym: "ACT_SITE 4-aspartylphosphate intermediate" EXACT UniProt-feature [] +synonym: "beta-aspartyl phosphate" EXACT RESID-alternate [] +synonym: "L-aspartic 4-phosphoric anhydride" EXACT RESID-name [] +synonym: "MOD_RES 4-aspartylphosphate" EXACT UniProt-feature [] +synonym: "PAsp" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 4 H 6 N 1 O 6 P 1" +xref: MassAvg: "195.07" +xref: MassMono: "194.993274" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01455 ! O-phosphorylated residue + +[Term] +id: MOD:00043 +name: S-phospho-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine." [PubMed:3142516, PubMed:7961745, PubMed:8128219, RESID:AA0034, UniMod:21#C] +synonym: "(2R)-2-amino-3-(phosphonosulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-(phosphonosulfanyl)propanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE Phosphocysteine intermediate" EXACT UniProt-feature [] +synonym: "cysteine phosphate thioester" EXACT RESID-alternate [] +synonym: "MOD_RES Phosphocysteine" EXACT UniProt-feature [] +synonym: "PCys" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "S-phospho-L-cysteine" EXACT RESID-name [] +synonym: "S-phosphonocysteine" EXACT RESID-alternate [] +synonym: "S-phosphorylated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S3-phosphocysteine" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1 S 0" +xref: DiffMono: "79.966331" +xref: Formula: "C 3 H 6 N 1 O 4 P 1 S 1" +xref: MassAvg: "183.12" +xref: MassMono: "182.975515" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00696 ! phosphorylated residue +is_a: MOD:00777 ! residues isobaric at 182.96-182.98 Da +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00044 +name: 1'-phospho-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine)." [PubMed:11038361, PubMed:5642389, PubMed:6692818, RESID:AA0035] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1'-phospho-L-histidine" EXACT RESID-name [] +synonym: "2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE Tele-phosphohistidine intermediate" EXACT UniProt-feature [] +synonym: "histidine-3-phosphate" RELATED RESID-misnomer [] +synonym: "histidine-N(epsilon)-phosphate" EXACT RESID-alternate [] +synonym: "histidine-N1'-phosphate" EXACT RESID-alternate [] +synonym: "MOD_RES Tele-phosphohistidine" EXACT UniProt-feature [] +synonym: "N(tau)-phosphohistidine" EXACT RESID-alternate [] +synonym: "N1-phosphonohistidine" EXACT RESID-alternate [] +synonym: "NE2-phosphonohistidine" EXACT RESID-alternate [] +synonym: "Ntau-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] +synonym: "NtPHis" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "tele-phosphohistidine" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 6 H 8 N 3 O 4 P 1" +xref: MassAvg: "217.12" +xref: MassMono: "217.025242" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00890 ! phosphorylated L-histidine + +[Term] +id: MOD:00045 +name: 3'-phospho-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine)." [PubMed:1549615, PubMed:5642389, PubMed:6692818, PubMed:7669763, PubMed:7803390, RESID:AA0036] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate [] +synonym: "3'-phospho-L-histidine" EXACT RESID-name [] +synonym: "ACT_SITE Pros-phosphohistidine intermediate" EXACT UniProt-feature [] +synonym: "histidine-1-phosphate" RELATED RESID-misnomer [] +synonym: "histidine-N(delta)-phosphate" EXACT RESID-alternate [] +synonym: "histidine-N3'-phosphate" EXACT RESID-alternate [] +synonym: "MOD_RES Pros-phosphohistidine" EXACT UniProt-feature [] +synonym: "N(pi)-phosphohistidine" EXACT RESID-alternate [] +synonym: "N3-phosphonohistidine" EXACT RESID-alternate [] +synonym: "ND1-phosphonohistidine" EXACT RESID-alternate [] +synonym: "Npi-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] +synonym: "NpPHis" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "pros-phosphohistidine" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 6 H 8 N 3 O 4 P 1" +xref: MassAvg: "217.12" +xref: MassMono: "217.025242" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00890 ! phosphorylated L-histidine + +[Term] +id: MOD:00046 +name: O-phospho-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-phospho-L-serine." [ChEBI:15811, DeltaMass:0, OMSSA:6, PubMed:12923550, PubMed:4065410, PubMed:8061611, RESID:AA0037, UniMod:21#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(phosphonooxy)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-hydroxypropanoic acid 3-phosphate" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(phosphonooxy)propanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE Phosphoserine intermediate" EXACT UniProt-feature [] +synonym: "MOD_RES Phosphoserine" EXACT UniProt-feature [] +synonym: "O-phospho-L-serine" EXACT RESID-name [] +synonym: "O-phosphonoserine" EXACT RESID-alternate [] +synonym: "O-phosphorylated L-serine" EXACT PSI-MOD-alternate [] +synonym: "O3-phosphoserine" EXACT RESID-alternate [] +synonym: "OPSer" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phospho Seryl" EXACT DeltaMass-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "phosphorylations" EXACT OMSSA-label [] +synonym: "serine phosphate ester" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 3 H 6 N 1 O 5 P 1" +xref: MassAvg: "167.06" +xref: MassMono: "166.998359" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00771 ! residues isobaric at 166.98-167.00 Da +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01455 ! O-phosphorylated residue + +[Term] +id: MOD:00047 +name: O-phospho-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine." [ChEBI:21967, DeltaMass:0, OMSSA:7, PubMed:12923550, PubMed:7678926, RESID:AA0038, UniMod:21#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(phosphonooxy)butanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-hydroxybutanoic acid 3-phosphate" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(phosphonooxy)butanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES Phosphothreonine" EXACT UniProt-feature [] +synonym: "O-phospho-L-threonine" EXACT RESID-name [] +synonym: "O-phosphorylated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "O3-phosphothreonine" EXACT RESID-alternate [] +synonym: "OPThr" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phospho Threonyl" EXACT DeltaMass-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "phosphorylationt" EXACT OMSSA-label [] +synonym: "threonine phosphate ester" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 4 H 8 N 1 O 5 P 1" +xref: MassAvg: "181.08" +xref: MassMono: "181.014009" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00773 ! residues isobaric at 181.00-181.02 Da +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01455 ! O-phosphorylated residue + +[Term] +id: MOD:00048 +name: O4'-phospho-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine." [DeltaMass:0, OMSSA:8, PubMed:10226369, PubMed:1725475, RESID:AA0039, UniMod:21#Y] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES Phosphotyrosine" EXACT UniProt-feature [] +synonym: "O4'-phospho-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-phosphorylated L-tyrosine" EXACT PSI-MOD-alternate [] +synonym: "O4-phosphotyrosine" EXACT RESID-alternate [] +synonym: "OPTyr" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phospho Tyrosinyl" EXACT DeltaMass-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "phosphorylationy" EXACT OMSSA-label [] +synonym: "tyrosine phosphate" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 9 H 10 N 1 O 5 P 1" +xref: MassAvg: "243.15" +xref: MassMono: "243.029659" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00774 ! residues isobaric at 243.02-243.03 Da +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01455 ! O-phosphorylated residue + +[Term] +id: MOD:00049 +name: 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to diphthamide." [ChEBI:16692, DeltaMass:122, PubMed:15316019, PubMed:7430147, RESID:AA0040, UniMod:375#H] +synonym: "(2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium" EXACT RESID-systematic [] +synonym: "(3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium" EXACT RESID-alternate [] +synonym: "1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium" EXACT RESID-alternate [] +synonym: "2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine" EXACT RESID-name [] +synonym: "2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole" EXACT RESID-alternate [] +synonym: "2-[3-carboxamido-3-(trimethylammonio)propyl]histidine" EXACT RESID-alternate [] +synonym: "2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide" EXACT RESID-alternate [] +synonym: "alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium" EXACT RESID-alternate [] +synonym: "Diphth" EXACT PSI-MOD-label [] +synonym: "Diphthamide" RELATED PSI-MS-label [] +synonym: "Diphthamide" RELATED UniMod-description [] +synonym: "diphthamide" EXACT RESID-alternate [] +synonym: "diphthamide (from histidine)" EXACT DeltaMass-label [] +synonym: "MOD_RES Diphthamide" EXACT UniProt-feature [] +xref: DiffAvg: "143.21" +xref: DiffFormula: "C 7 H 15 N 2 O 1" +xref: DiffMono: "143.117890" +xref: FormalCharge: "1+" +xref: Formula: "C 13 H 22 N 5 O 2" +xref: MassAvg: "280.35" +xref: MassMono: "280.176801" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00050 +name: N-acetyl-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine." [PubMed:363452, PubMed:4700463, RESID:AA0041] +subset: PSI-MOD-slim +synonym: "(2S)-2-(acetamido)propanoic acid" EXACT RESID-systematic [] +synonym: "2-(acetylamino)propanoic acid" EXACT RESID-alternate [] +synonym: "2-(acetylazanyl)propanoic acid" EXACT RESID-alternate [] +synonym: "AcAla" EXACT PSI-MOD-label [] +synonym: "acetylalanine" EXACT RESID-alternate [] +synonym: "MOD_RES N-acetylalanine" EXACT UniProt-feature [] +synonym: "N-acetyl-L-alanine" EXACT RESID-name [] +synonym: "N-acetylated L-alanine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 5 H 8 N 1 O 2" +xref: MassAvg: "114.12" +xref: MassMono: "114.055504" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00051 +name: N-acetyl-L-aspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid." [ChEBI:21547, PubMed:1560020, PubMed:2395459, RESID:AA0042] +subset: PSI-MOD-slim +synonym: "(2S)-2-(acetamido)butanedioic acid" EXACT RESID-systematic [] +synonym: "2-(acetylamino)butanedioic acid" EXACT RESID-alternate [] +synonym: "2-(acetylazanyl)butanedioic acid" EXACT RESID-alternate [] +synonym: "AcAsp" EXACT PSI-MOD-label [] +synonym: "acetylaspartic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N-acetylaspartate" EXACT UniProt-feature [] +synonym: "N-acetyl-L-aspartic acid" EXACT RESID-name [] +synonym: "N-acetylated L-aspartic acid" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 6 H 8 N 1 O 4" +xref: MassAvg: "158.13" +xref: MassMono: "158.045333" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00052 +name: N-acetyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine." [ChEBI:28939, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:1500421, PubMed:15350136, PubMed:6725286, RESID:AA0043] +comment: incidental to RESID:AA0223 +subset: PSI-MOD-slim +synonym: "(2R)-2-acetamido-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-3-mercaptopropanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylamino-3-sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-3-sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "MOD_RES N-acetylcysteine" EXACT UniProt-feature [] +synonym: "N-acetyl-L-cysteine" EXACT RESID-name [] +synonym: "N-acetylated cysteine" EXACT PSI-MOD-alternate [] +synonym: "N-acetylcysteine" EXACT RESID-alternate [] +synonym: "NAcCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" +xref: DiffMono: "42.010565" +xref: Formula: "C 5 H 8 N 1 O 2 S 1" +xref: MassAvg: "146.18" +xref: MassMono: "146.027574" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00646 ! acetylated L-cysteine +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00053 +name: N-acetyl-L-glutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid." [ChEBI:17533, PubMed:6725286, RESID:AA0044] +subset: PSI-MOD-slim +synonym: "(2S)-2-(acetamido)pentanedioic acid" EXACT RESID-systematic [] +synonym: "2-(acetylamino)pentanedioic acid" EXACT RESID-alternate [] +synonym: "2-(acetylazanyl)pentanedioic acid" EXACT RESID-alternate [] +synonym: "acetylglutamic acid" EXACT RESID-alternate [] +synonym: "AcGlu" EXACT PSI-MOD-label [] +synonym: "MOD_RES N-acetylglutamate" EXACT UniProt-feature [] +synonym: "N-acetyl-L-glutamic acid" EXACT RESID-name [] +synonym: "N-acetylated L-glutamic acid" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 7 H 10 N 1 O 4" +xref: MassAvg: "172.16" +xref: MassMono: "172.060983" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00054 +name: N-acetyl-L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine." [RESID:AA0045] +comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2S)-2-acetamido-5-pentanediamic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-5-amino-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylamino-5-pentanediamic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-5-azanyl-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "acetylglutamine" EXACT RESID-alternate [] +synonym: "AcGln" EXACT PSI-MOD-label [] +synonym: "N-acetyl-L-glutamine" EXACT RESID-name [] +synonym: "N-acetylated L-glutamine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 7 H 11 N 2 O 3" +xref: MassAvg: "171.18" +xref: MassMono: "171.076967" +xref: Origin: "Q" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00055 +name: N-acetylglycine +def: "A protein modification that effectively converts a glycine residue to N-acetylglycine." [PubMed:272676, PubMed:5545094, PubMed:6754709, RESID:AA0046] +subset: PSI-MOD-slim +synonym: "(acetylamino)acetic acid" EXACT RESID-alternate [] +synonym: "(acetylazanyl)ethanoic acid" EXACT RESID-alternate [] +synonym: "2-(acetamido)ethanoic acid" EXACT RESID-systematic [] +synonym: "2-(acetylamino)ethanoic acid" EXACT RESID-alternate [] +synonym: "aceturic acid" EXACT RESID-alternate [] +synonym: "AcGly" EXACT PSI-MOD-label [] +synonym: "MOD_RES N-acetylglycine" EXACT UniProt-feature [] +synonym: "N-acetylated glycine" EXACT PSI-MOD-alternate [] +synonym: "N-acetylglycine" EXACT RESID-name [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 4 H 6 N 1 O 2" +xref: MassAvg: "100.10" +xref: MassMono: "100.039853" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00056 +name: N-acetyl-L-isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine." [PubMed:8034631, RESID:AA0047] +comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2S,3S)-2-acetamido-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-3-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-3-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "acetylisoleucine" EXACT RESID-alternate [] +synonym: "AcIle" EXACT PSI-MOD-label [] +synonym: "N-acetyl-L-isoleucine" EXACT RESID-name [] +synonym: "N-acetylated L-isoleucine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 14 N 1 O 2" +xref: MassAvg: "156.20" +xref: MassMono: "156.102454" +xref: Origin: "I" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00057 +name: N2-acetyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, RESID:AA0048] +comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2S)-2-acetamido-6-aminohexanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-6-aminohexanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-6-azanylhexanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "N2-acetyl-L-lysine" EXACT RESID-name [] +synonym: "N2-acetylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N2-acetyllysine" EXACT RESID-alternate [] +synonym: "N2AcLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 15 N 2 O 2" +xref: MassAvg: "171.22" +xref: MassMono: "171.113353" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00723 ! N-acetylated L-lysine +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00058 +name: N-acetyl-L-methionine +def: "A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine." [PubMed:7944406, RESID:AA0049] +subset: PSI-MOD-slim +synonym: "(2S)-2-acetamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "acetylmethionine" EXACT RESID-alternate [] +synonym: "AcMet" EXACT PSI-MOD-label [] +synonym: "methionamine" EXACT RESID-alternate [] +synonym: "MOD_RES N-acetylmethionine" EXACT UniProt-feature [] +synonym: "N-acetyl-L-methionine" EXACT RESID-name [] +synonym: "N-acetylated L-methionine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" +xref: DiffMono: "42.010565" +xref: Formula: "C 7 H 12 N 1 O 2 S 1" +xref: MassAvg: "174.24" +xref: MassMono: "174.058875" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00059 +name: N-acetyl-L-proline +def: "A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline." [PubMed:2928307, RESID:AA0050] +subset: PSI-MOD-slim +synonym: "(2S)-1-acetyl-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] +synonym: "1-acetylproline" EXACT RESID-alternate [] +synonym: "acetylproline" EXACT RESID-alternate [] +synonym: "MOD_RES N-acetylproline" EXACT UniProt-feature [] +synonym: "N-acetyl-L-proline" EXACT RESID-name [] +synonym: "N-acetylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "N-acetylproline" EXACT RESID-alternate [] +synonym: "NAcPro" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 7 H 10 N 1 O 2" +xref: MassAvg: "140.16" +xref: MassMono: "140.071154" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00060 +name: N-acetyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:1880797, PubMed:2106685, PubMed:6997045, RESID:AA0051] +subset: PSI-MOD-slim +synonym: "(2S)-2-acetamido-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-3-hydroxypropanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-3-hydroxypropanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "MOD_RES N-acetylserine" EXACT UniProt-feature [] +synonym: "N-acetyl-L-serine" EXACT RESID-name [] +synonym: "N-acetylated L-serine" EXACT PSI-MOD-alternate [] +synonym: "N-acetylserine" EXACT RESID-alternate [] +synonym: "NAcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 5 H 8 N 1 O 3" +xref: MassAvg: "130.12" +xref: MassMono: "130.050418" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00647 ! acetylated L-serine +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00061 +name: N-acetyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:2106685, PubMed:6997045, RESID:AA0052] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-acetamido-3-hydroxybutanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-3-hydroxybutanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-3-hydroxybutanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "Acetylation" RELATED UniMod-description [] +synonym: "MOD_RES N-acetylthreonine" EXACT UniProt-feature [] +synonym: "N-acetyl-L-threonine" EXACT RESID-name [] +synonym: "N-acetylated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "N-acetylthreonine" EXACT RESID-alternate [] +synonym: "N-methylcarbonylthreonine" EXACT RESID-alternate [] +synonym: "NAcThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 6 H 10 N 1 O 3" +xref: MassAvg: "144.15" +xref: MassMono: "144.066068" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01186 ! acetylated L-threonine +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00062 +name: N-acetyl-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:2506074, PubMed:475783, RESID:AA0053] +synonym: "(2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "AcTyr" EXACT PSI-MOD-label [] +synonym: "MOD_RES N-acetyltyrosine" EXACT UniProt-feature [] +synonym: "N-acetyl-L-tyrosine" EXACT RESID-name [] +synonym: "N-acetylated L-tyrosine" EXACT PSI-MOD-alternate [] +synonym: "N-acetyltyrosine" EXACT RESID-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 11 H 12 N 1 O 3" +xref: MassAvg: "206.22" +xref: MassMono: "206.081718" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00063 +name: N-acetyl-L-valine +def: "A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine." [PubMed:1735421, RESID:AA0054] +subset: PSI-MOD-slim +synonym: "(2S)-2-acetamido-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "2-acetylamino-3-methylbutanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylazanyl-3-methylbutanoic acid" EXACT RESID-alternate [] +synonym: "AcVal" EXACT PSI-MOD-label [] +synonym: "MOD_RES N-acetylvaline" EXACT UniProt-feature [] +synonym: "N-acetyl-L-valine" EXACT RESID-name [] +synonym: "N-acetylated L-valine" EXACT PSI-MOD-alternate [] +synonym: "N-acetylvaline" EXACT RESID-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 7 H 12 N 1 O 2" +xref: MassAvg: "142.18" +xref: MassMono: "142.086804" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00064 +name: N6-acetyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine." [ChEBI:17752, DeltaMass:214, OMSSA:24, PubMed:11369851, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:1680872, PubMed:670159, RESID:AA0055, UniMod:1#K] +subset: PSI-MOD-slim +synonym: "(2S)-6-acetamido-2-aminohexanoic acid" EXACT RESID-systematic [] +synonym: "6-acetylamino-2-aminohexanoic acid" EXACT RESID-alternate [] +synonym: "6-acetylazanyl-2-aminohexanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "Acetylation" RELATED UniMod-description [] +synonym: "acetylk" EXACT OMSSA-label [] +synonym: "epsilon-acetyllysine" EXACT RESID-alternate [] +synonym: "MOD_RES N6-acetyllysine" EXACT UniProt-feature [] +synonym: "N(zeta)-acetyllysine" EXACT RESID-alternate [] +synonym: "N6-acetyl-L-lysine" EXACT RESID-name [] +synonym: "N6-acetylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6AcLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 14 N 2 O 2" +xref: MassAvg: "170.21" +xref: MassMono: "170.105528" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00723 ! N-acetylated L-lysine +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00065 +name: S-acetyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:1310545, PubMed:14730666, PubMed:15350136, RESID:AA0056, UniMod:1#C] +subset: PSI-MOD-slim +synonym: "(2R)-3-acetylsulfanyl-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(acetylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(acetylsulfanyl)propanoic acid" EXACT RESID-alternate [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "Acetylation" RELATED UniMod-description [] +synonym: "ACT_SITE S-acetylcysteine intermediate" EXACT UniProt-feature [] +synonym: "cysteine acetate thioester" EXACT RESID-alternate [] +synonym: "S-acetyl-L-cysteine" EXACT RESID-name [] +synonym: "S-acetylcysteine" EXACT RESID-alternate [] +synonym: "SAcCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" +xref: DiffMono: "42.010565" +xref: Formula: "C 5 H 7 N 1 O 2 S 1" +xref: MassAvg: "145.18" +xref: MassMono: "145.019749" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00645 ! S-acetylated residue +is_a: MOD:00646 ! acetylated L-cysteine + +[Term] +id: MOD:00066 +name: N-formylglycine +def: "A protein modification that effectively converts a glycine residue to N-formylglycine." [PubMed:5139483, RESID:AA0057] +synonym: "(formylamino)acetic acid" EXACT RESID-alternate [] +synonym: "(formylamino)ethanoic acid" EXACT RESID-systematic [] +synonym: "(formylazanyl)ethanoic acid" EXACT RESID-alternate [] +synonym: "2-formamidoacetic acid" EXACT RESID-alternate [] +synonym: "2-formamidoethanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N-formylglycine" EXACT UniProt-feature [] +synonym: "N(alpha)-formylglycine" EXACT RESID-alternate [] +synonym: "N-formylated glycine" EXACT PSI-MOD-alternate [] +synonym: "N-formylglycine" EXACT RESID-name [] +synonym: "NFoGly" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 3 H 4 N 1 O 2" +xref: MassAvg: "86.07" +xref: MassMono: "86.024203" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00067 +name: N-D-glucuronoylglycine +def: "A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine." [OMSSA:50, PubMed:10858503, PubMed:12716131, PubMed:6493057, PubMed:7398618, RESID:AA0058] +synonym: "2-(glucuronoylamino)ethanoic acid" EXACT RESID-systematic [] +synonym: "Glucuronyl" RELATED PSI-MS-label [] +synonym: "MOD_RES N-D-glucuronoyl glycine" EXACT UniProt-feature [] +synonym: "N-D-glucuronoyl-glycine" EXACT RESID-name [] +synonym: "N-D-glucuronyl-glycine" EXACT RESID-alternate [] +synonym: "NGlcAGly" EXACT PSI-MOD-label [] +synonym: "ntermpepglucuronylg" EXACT OMSSA-label [] +xref: DiffAvg: "176.12" +xref: DiffFormula: "C 6 H 8 N 0 O 6" +xref: DiffMono: "176.032088" +xref: Formula: "C 8 H 12 N 1 O 7" +xref: MassAvg: "234.18" +xref: MassMono: "234.061377" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00447 ! N-glucuronylated residue +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:00068 +name: N-myristoylglycine +def: "A protein modification that effectively converts a glycine residue to N-myristoylglycine." [OMSSA:80, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059, UniMod:45#G] +subset: PSI-MOD-slim +synonym: "(tetradecanoylamino)ethanoic acid" EXACT RESID-systematic [] +synonym: "LIPID N-myristoyl glycine" EXACT UniProt-feature [] +synonym: "Myristoyl" RELATED PSI-MS-label [] +synonym: "Myristoylation" RELATED UniMod-description [] +synonym: "N-(1-oxotetradecyl)glycine" EXACT RESID-alternate [] +synonym: "N-(C14:0 aliphatic acyl)glycine" EXACT PSI-MOD-alternate [] +synonym: "N-myristoyl-glycine" EXACT RESID-name [] +synonym: "N-myristoylated glycine" EXACT PSI-MOD-alternate [] +synonym: "N-myristylglycine" EXACT RESID-alternate [] +synonym: "N-tetradecanoylglycine" EXACT RESID-alternate [] +synonym: "NMyrGly" EXACT PSI-MOD-label [] +synonym: "ntermpepmyristoylationg" EXACT OMSSA-label [] +xref: DiffAvg: "210.36" +xref: DiffFormula: "C 14 H 26 N 0 O 1" +xref: DiffMono: "210.198365" +xref: Formula: "C 16 H 30 N 1 O 2" +xref: MassAvg: "268.42" +xref: MassMono: "268.227654" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00650 ! N-myristoylated residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00069 +name: N-palmitoyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, PubMed:9593755, RESID:AA0060] +comment: incidental to RESID:AA0107 incidental to RESID:AA0309 +subset: PSI-MOD-slim +synonym: "(2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-hexadecanamido-3-sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-hexadecanoylamino-3-mercaptopropanoic acid" EXACT RESID-alternate [] +synonym: "LIPID N-palmitoyl cysteine" EXACT UniProt-feature [] +synonym: "N-(1-oxahexadecyl)-L-cysteine" EXACT RESID-alternate [] +synonym: "N-palmitoyl-L-cysteine" EXACT RESID-name [] +synonym: "N-palmitoylated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "NPamCys" EXACT PSI-MOD-label [] +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "C 19 H 36 N 1 O 2 S 1" +xref: MassAvg: "342.56" +xref: MassMono: "342.246675" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01684 ! palmitoylated-L-cysteine +is_a: MOD:01685 ! alpha-amino palmitoylated residue + +[Term] +id: MOD:00070 +name: N-methyl-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine." [ChEBI:17519, PubMed:323502, PubMed:337304, PubMed:7007074, RESID:AA0061] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-methylaminopropanoic acid" EXACT RESID-systematic [] +synonym: "2-methylazanylpropanoic acid" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N-methylalanine" EXACT UniProt-feature [] +synonym: "N-methyl-L-alanine" EXACT RESID-name [] +synonym: "N-methylalanine" EXACT RESID-alternate [] +synonym: "N-methylated L-alanine" EXACT PSI-MOD-alternate [] +synonym: "NMe1Ala" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 4 H 7 N 1 O 1" +xref: MassAvg: "85.11" +xref: MassMono: "85.052764" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01461 ! N-methylated alanine +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00071 +name: N,N,N-trimethyl-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine." [PubMed:12590383, PubMed:332162, PubMed:3979397, PubMed:6778808, PubMed:7715456, RESID:AA0062] +subset: PSI-MOD-slim +synonym: "(1S)-1-carboxy-N,N,N-trimethylethanaminium" EXACT RESID-systematic [] +synonym: "(1S)-1-carboxy-N,N,N-trimethylethanazanium" EXACT RESID-alternate [] +synonym: "(2S)-2-(trimethylammonio)propanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N,N,N-trimethylalanine" EXACT UniProt-feature [] +synonym: "N,N,N-trimethyl-L-alanine" EXACT RESID-name [] +synonym: "N,N,N-trimethylalanine cation" EXACT RESID-alternate [] +synonym: "N,N,N-trimethylalaninium" EXACT RESID-alternate [] +synonym: "N,N,N-trimethylated L-alanine" EXACT PSI-MOD-alternate [] +synonym: "N2Me3+Ala" EXACT PSI-MOD-label [] +synonym: "NMe3Ala" EXACT PSI-MOD-label [] +synonym: "tri-Methylation" RELATED UniMod-description [] +synonym: "Trimethyl" RELATED PSI-MS-label [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0" +xref: DiffMono: "43.054227" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 13 N 1 O 1" +xref: MassAvg: "115.18" +xref: MassMono: "115.099165" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01461 ! N-methylated alanine +is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue + +[Term] +id: MOD:00072 +name: N-methylglycine +def: "A protein modification that effectively converts a glycine residue to N-methylglycine." [ChEBI:15611, DeltaMass:0, PubMed:1593629, RESID:AA0063] +comment: DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +synonym: "L-sarcosine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methylaminoacetic acid" EXACT RESID-alternate [] +synonym: "methylaminoethanoic acid" EXACT RESID-systematic [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "N-methylated glycine" EXACT PSI-MOD-alternate [] +synonym: "N-methylglycine" EXACT RESID-name [] +synonym: "NMe1Gly" EXACT PSI-MOD-label [] +synonym: "Sar" EXACT DeltaMass-label [] +synonym: "Sarcosine" EXACT DeltaMass-label [] +synonym: "Sarcosyl" EXACT DeltaMass-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00570 ! residues isobaric at 71.037114 Da +is_a: MOD:00714 ! methylated glycine +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00073 +name: N-methyl-L-methionine +def: "A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine." [DeltaMass:169, PubMed:323502, PubMed:3298225, RESID:AA0064] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-methylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-methylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methyl Methionyl" EXACT DeltaMass-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N-methylmethionine" EXACT UniProt-feature [] +synonym: "N-methyl-L-methionine" EXACT RESID-name [] +synonym: "N-methylated L-methionine" EXACT PSI-MOD-alternate [] +synonym: "N-methylmethionine" EXACT RESID-alternate [] +synonym: "NMe1Met" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 11 N 1 O 1 S 1" +xref: MassAvg: "145.22" +xref: MassMono: "145.056135" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01463 ! N-methylated methionine +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00074 +name: N-methyl-L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine." [PubMed:2577730, PubMed:413571, RESID:AA0065] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-methylamino-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N-methylphenylalanine" EXACT UniProt-feature [] +synonym: "N-methyl-L-phenylalanine" EXACT RESID-name [] +synonym: "N-methylated L-phenylalanine" EXACT PSI-MOD-alternate [] +synonym: "N-methylphenylalanine" EXACT RESID-alternate [] +synonym: "NMe1Phe" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 10 H 11 N 1 O 1" +xref: MassAvg: "161.20" +xref: MassMono: "161.084064" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01063 ! monomethylated phenylalanine +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00075 +name: N,N-dimethyl-L-proline +def: "A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline." [ChEBI:21451, PubMed:12964758, PubMed:14570711, PubMed:193025, PubMed:3882426, PubMed:6254758, RESID:AA0066, UniMod:529] +comment: UniMod terminal specification corrected [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-carboxy-1,1-dimethylpyrrolidinium" EXACT RESID-systematic [] +synonym: "1,1-dimethyl-L-prolinium" EXACT RESID-alternate [] +synonym: "Delta:H(5)C(2)" RELATED UniMod-interim [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "Dimethylation of proline residue" RELATED UniMod-description [] +synonym: "MOD_RES N,N-dimethylproline" EXACT UniProt-feature [] +synonym: "N,N-dimethyl-L-proline" EXACT RESID-name [] +synonym: "N,N-dimethyl-L-prolinium" EXACT RESID-alternate [] +synonym: "N,N-dimethylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "NMe2Pro" EXACT PSI-MOD-label [] +synonym: "stachydrin" EXACT RESID-alternate [] +xref: DiffAvg: "29.06" +xref: DiffFormula: "C 2 H 5 N 0 O 0" +xref: DiffMono: "29.038577" +xref: FormalCharge: "1+" +xref: Formula: "C 7 H 13 N 1 O 1" +xref: MassAvg: "127.19" +xref: MassMono: "127.099165" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00710 ! protonated-dimethylated residue +is_a: MOD:01462 ! N-methylated proline + +[Term] +id: MOD:00076 +name: symmetric dimethyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine." [PubMed:12964758, PubMed:14570711, PubMed:15835918, PubMed:2426402, PubMed:5128665, RESID:AA0067, UniMod:36#R] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid" EXACT RESID-systematic [] +synonym: "di-Methylation" RELATED UniMod-description [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature [] +synonym: "MOD_RES Symmetric dimethylarginine" EXACT UniProt-feature [] +synonym: "N3,N4-dimethylarginine" EXACT RESID-alternate [] +synonym: "N5-[(methylamino)(methylimino)methyl]ornithine" EXACT RESID-alternate [] +synonym: "NG,N'G-dimethylarginine" EXACT RESID-alternate [] +synonym: "NoNo'Me2Arg" EXACT PSI-MOD-label [] +synonym: "omega-N,omega-N'-dimethyl-L-arginine" EXACT RESID-name [] +synonym: "omega-N,omega-N'-dimethylated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "symmetric dimethylarginine" EXACT RESID-alternate [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 4 O 1" +xref: MassAvg: "184.24" +xref: MassMono: "184.132411" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00783 ! dimethylated L-arginine + +[Term] +id: MOD:00077 +name: asymmetric dimethyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine." [ChEBI:17929, PubMed:11152131, PubMed:12964758, PubMed:14570711, PubMed:15835918, PubMed:3032834, RESID:AA0068, UniMod:36#R] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] +synonym: "asymmetric dimethylarginine" EXACT RESID-alternate [] +synonym: "di-Methylation" RELATED UniMod-description [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "MOD_RES Asymmetric dimethylarginine" EXACT UniProt-feature [] +synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature [] +synonym: "N5-[(dimethylamino)(imino)methyl]ornithine" EXACT RESID-alternate [] +synonym: "NG,NG-dimethylarginine" EXACT RESID-alternate [] +synonym: "NoNoMe2Arg" EXACT PSI-MOD-label [] +synonym: "omega-N,omega-N-dimethlyated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "omega-N,omega-N-dimethyl-L-arginine" EXACT RESID-name [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 4 O 1" +xref: MassAvg: "184.24" +xref: MassMono: "184.132411" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00783 ! dimethylated L-arginine + +[Term] +id: MOD:00078 +name: omega-N-methyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine." [PubMed:11875433, PubMed:15835918, PubMed:2426402, PubMed:5128665, RESID:AA0069] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid" EXACT RESID-systematic [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES Omega-N-methylarginine" EXACT UniProt-feature [] +synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature [] +synonym: "NG-methylarginine" EXACT RESID-alternate [] +synonym: "NoMeArg" EXACT PSI-MOD-label [] +synonym: "omega-N-methyl-L-arginine" EXACT RESID-name [] +synonym: "omega-N-methylated L-arginine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 14 N 4 O 1" +xref: MassAvg: "170.22" +xref: MassMono: "170.116761" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00414 ! monomethylated L-arginine +is_a: MOD:00602 ! N-methylated residue + +[Term] +id: MOD:00079 +name: N4-methyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine." [OMSSA:75, PubMed:11875433, PubMed:2356973, PubMed:3782095, RESID:AA0070, UniMod:34#N] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-N4-methylbutanediamic acid" EXACT RESID-systematic [] +synonym: "beta-aspartyl methylamide" EXACT RESID-alternate [] +synonym: "beta-methylasparagine" RELATED RESID-misnomer [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "methyln" EXACT OMSSA-label [] +synonym: "MOD_RES N4-methylasparagine" EXACT UniProt-feature [] +synonym: "N(gamma)-methylasparagine" EXACT RESID-alternate [] +synonym: "N-methylasparagine" EXACT RESID-alternate [] +synonym: "N4-methyl-L-asparagine" EXACT RESID-name [] +synonym: "N4-methylated L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "N4Me1Asn" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 5 H 8 N 2 O 2" +xref: MassAvg: "128.13" +xref: MassMono: "128.058578" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00673 ! methylated asparagine +is_a: MOD:00894 ! residues isobaric at 128.058578 Da + +[Term] +id: MOD:00080 +name: N5-methyl-L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine." [ChEBI:17592, DeltaMass:166, PubMed:11118225, PubMed:11875433, PubMed:365579, RESID:AA0071] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-methylamino-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N5-methylpentanediamic acid" EXACT RESID-alternate [] +synonym: "gamma-methylglutamine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N5-methylglutamine" EXACT UniProt-feature [] +synonym: "N(delta)-methylglutamine" EXACT RESID-alternate [] +synonym: "N-methylglutamine" EXACT RESID-alternate [] +synonym: "N5-methyl-L-glutamine" EXACT RESID-name [] +synonym: "N5-methylated L-glutamine" EXACT PSI-MOD-alternate [] +synonym: "N5Me1Gln" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 10 N 2 O 2" +xref: MassAvg: "142.16" +xref: MassMono: "142.074228" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00722 ! monomethylated L-glutamine + +[Term] +id: MOD:00081 +name: L-glutamic acid 5-methyl ester (Glu) +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester." [DeltaMass:167, OMSSA:17, OMSSA:70, PubMed:16888, PubMed:6300110, RESID:AA0072#GLU, UniMod:34#E] +comment: DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate [] +synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate [] +synonym: "5-methyl esterified L-glutamic acid" EXACT PSI-MOD-alternate [] +synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate [] +synonym: "5-methyl L-glutamate" EXACT RESID-alternate [] +synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate [] +synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate [] +synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name [] +synonym: "meestere" EXACT OMSSA-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methyl ester" RELATED UniMod-alternate [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "methyle" EXACT OMSSA-label [] +synonym: "MOD_RES Glutamate methyl ester (Glu)" EXACT UniProt-feature [] +synonym: "O-methyl Glutamyl" EXACT DeltaMass-label [] +synonym: "O5MeGlu" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 9 N 1 O 3" +xref: MassAvg: "143.14" +xref: MassMono: "143.058243" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01453 ! L-glutamic acid 5-methyl ester + +[Term] +id: MOD:00082 +name: 3'-methyl-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine)." [PubMed:10660523, PubMed:11875433, PubMed:3467365, PubMed:6692818, PubMed:8076, PubMed:8645219, RESID:AA0073] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1-methylhistidine" RELATED RESID-misnomer [] +synonym: "3'-methyl-L-histidine" EXACT RESID-name [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES Pros-methylhistidine" EXACT UniProt-feature [] +synonym: "N(delta)-methylhistidine" EXACT RESID-alternate [] +synonym: "N(pi)-methylhistidine" EXACT RESID-alternate [] +synonym: "NpMeHis" EXACT PSI-MOD-label [] +synonym: "pros-methylated L-histidine" EXACT PSI-MOD-alternate [] +synonym: "pros-methylhistidine" EXACT RESID-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 9 N 3 O 1" +xref: MassAvg: "151.17" +xref: MassMono: "151.074562" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00724 ! N-methylated L-histidine + +[Term] +id: MOD:00083 +name: N6,N6,N6-trimethyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine." [ChEBI:17311, PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, RESID:AA0074] +comment: DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855 +subset: PSI-MOD-slim +synonym: "(5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium" EXACT RESID-systematic [] +synonym: "2-amino-6-(trimethylammonio)hexanoic acid" EXACT RESID-alternate [] +synonym: "5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium" EXACT RESID-alternate [] +synonym: "epsilon-trimethyllysine" EXACT RESID-alternate [] +synonym: "MOD_RES N6,N6,N6-trimethyllysine" EXACT UniProt-feature [] +synonym: "N(zeta)-trimethyllysine" EXACT RESID-alternate [] +synonym: "N-trimethylation (of lysine)" EXACT DeltaMass-label [] +synonym: "N6,N6,N6-trimethyl-L-lysine" EXACT RESID-name [] +synonym: "N6,N6,N6-trimethylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6,N6,N6-trimethyllysin-N6-ium" EXACT RESID-alternate [] +synonym: "N6,N6,N6-trimethyllysine cation" EXACT RESID-alternate [] +synonym: "N6Me3+Lys" EXACT PSI-MOD-label [] +synonym: "tri-Methylation" RELATED UniMod-description [] +synonym: "Trimethyl" RELATED PSI-MS-label [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0" +xref: DiffMono: "43.054227" +xref: FormalCharge: "1+" +xref: Formula: "C 9 H 19 N 2 O 1" +xref: MassAvg: "171.26" +xref: MassMono: "171.149190" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00663 ! methylated lysine +is_a: MOD:00711 ! trimethylated protonated-residue + +[Term] +id: MOD:00084 +name: N6,N6-dimethyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine." [OMSSA:36, PubMed:10550045, PubMed:12964758, PubMed:14570711, PubMed:3100523, PubMed:8453381, RESID:AA0075, UniMod:36#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(dimethylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "di-Methylation" RELATED UniMod-description [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "dimethylk" EXACT OMSSA-label [] +synonym: "epsilon-dimethyllysine" EXACT RESID-alternate [] +synonym: "lysine derivative Lys(y)" EXACT RESID-alternate [] +synonym: "MOD_RES N6,N6-dimethyllysine" EXACT UniProt-feature [] +synonym: "N(zeta)-dimethyllysine" EXACT RESID-alternate [] +synonym: "N6,N6-dimethyl-L-lysine" EXACT RESID-name [] +synonym: "N6,N6-dimethylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6Me2Lys" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 2 O 1" +xref: MassAvg: "156.23" +xref: MassMono: "156.126263" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00429 ! dimethylated residue +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00663 ! methylated lysine + +[Term] +id: MOD:00085 +name: N6-methyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine." [ChEBI:17604, DeltaMass:165, PubMed:11875433, PubMed:3926756, RESID:AA0076, UniMod:34#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-methylaminohexanoic acid" EXACT RESID-systematic [] +synonym: "epsilon-methyllysine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N6-methyllysine" EXACT UniProt-feature [] +synonym: "N(zeta)-methyllysine" EXACT RESID-alternate [] +synonym: "N-methyl Lysyl" EXACT DeltaMass-label [] +synonym: "N6-methyl-L-lysine" EXACT RESID-name [] +synonym: "N6-methylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6Me1Lys" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 14 N 2 O 1" +xref: MassAvg: "142.20" +xref: MassMono: "142.110613" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:01683 ! monomethylated L-lysine + +[Term] +id: MOD:00086 +name: N6-palmitoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine." [OMSSA:93, PubMed:2498336, PubMed:7801126, PubMed:7939682, RESID:AA0077, UniMod:47#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(hexadecanoylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-6-(hexadecanamido)hexanoic acid" EXACT RESID-alternate [] +synonym: "epsilon-palmitoyllysine" EXACT RESID-alternate [] +synonym: "LIPID N6-palmitoyl lysine" EXACT UniProt-feature [] +synonym: "N(zeta)-palmitoyllysine" EXACT RESID-alternate [] +synonym: "N6-(1-oxohexadecyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-palmitoyl-L-lysine" EXACT RESID-name [] +synonym: "N6-palmitoylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6PamLys" EXACT PSI-MOD-label [] +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +synonym: "palmitoylationk" EXACT OMSSA-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1" +xref: DiffMono: "238.229666" +xref: Formula: "C 22 H 42 N 2 O 2" +xref: MassAvg: "366.59" +xref: MassMono: "366.324629" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00651 ! N-palmitoylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00087 +name: N6-myristoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine." [OMSSA:81, PubMed:1402651, PubMed:8346241, RESID:AA0078, UniMod:45#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(tetradecanoylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-6-(tetradecanamido)hexanoic acid" EXACT RESID-alternate [] +synonym: "epsilon-myristoyllysine" EXACT RESID-alternate [] +synonym: "LIPID N6-myristoyl lysine" EXACT UniProt-feature [] +synonym: "Myristoyl" RELATED PSI-MS-label [] +synonym: "Myristoylation" RELATED UniMod-description [] +synonym: "myristoylationk" EXACT OMSSA-label [] +synonym: "N(zeta)-myristoyllysine" EXACT RESID-alternate [] +synonym: "N6-(1-oxotetradecyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-(C14:0 aliphatic acyl)lysine" EXACT PSI-MOD-alternate [] +synonym: "N6-myristoyl-L-lysine" EXACT RESID-name [] +synonym: "N6-myristoylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6MyrLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "210.36" +xref: DiffFormula: "C 14 H 26 N 0 O 1" +xref: DiffMono: "210.198365" +xref: Formula: "C 20 H 38 N 2 O 2" +xref: MassAvg: "338.54" +xref: MassMono: "338.293328" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00650 ! N-myristoylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00088 +name: O-palmitoyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine." [OMSSA:95, PubMed:6642431, PubMed:8413602, RESID:AA0079, UniMod:47#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "L-threonine hexadecanoate ester" EXACT RESID-alternate [] +synonym: "LIPID O-palmitoyl threonine" EXACT UniProt-feature [] +synonym: "O-palmitoyl-L-threonine" EXACT RESID-name [] +synonym: "O-palmitoylated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "O3-palmitoyl-threonine" EXACT RESID-alternate [] +synonym: "OPamThr" EXACT PSI-MOD-label [] +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +synonym: "palmitoylationt" EXACT OMSSA-label [] +synonym: "threonine palmitate ester" EXACT RESID-alternate [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1" +xref: DiffMono: "238.229666" +xref: Formula: "C 20 H 37 N 1 O 3" +xref: MassAvg: "339.52" +xref: MassMono: "339.277344" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00652 ! O-palmitoylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00089 +name: O-palmitoyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine." [OMSSA:94, PubMed:3467339, RESID:AA0080, UniMod:47#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(hexadecanoyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE O-palmitoyl serine intermediate" EXACT UniProt-feature [] +synonym: "L-serine hexadecanoate ester" EXACT RESID-alternate [] +synonym: "LIPID O-palmitoyl serine" EXACT UniProt-feature [] +synonym: "O-palmitoyl-L-serine" EXACT RESID-name [] +synonym: "O-palmitoylated L-serine" EXACT PSI-MOD-alternate [] +synonym: "O3-palmitoyl-serine" EXACT RESID-alternate [] +synonym: "OPamSer" EXACT PSI-MOD-label [] +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +synonym: "palmitoylations" EXACT OMSSA-label [] +synonym: "serine palmitate ester" EXACT RESID-alternate [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1" +xref: DiffMono: "238.229666" +xref: Formula: "C 19 H 35 N 1 O 3" +xref: MassAvg: "325.49" +xref: MassMono: "325.261694" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00652 ! O-palmitoylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00090 +name: L-alanine amide +def: "A protein modification that effectively converts an L-alanine residue to L-alanine amide." [PubMed:1377792, PubMed:2069951, PubMed:8472537, PubMed:952951, RESID:AA0081] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminopropanamide" EXACT RESID-systematic [] +synonym: "AlaN" EXACT PSI-MOD-label [] +synonym: "alaninamide" EXACT RESID-alternate [] +synonym: "amidated L-alanine" EXACT PSI-MOD-alternate [] +synonym: "L-alanine amide" EXACT RESID-name [] +synonym: "MOD_RES Alanine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 3 H 7 N 2 O 1" +xref: MassAvg: "87.10" +xref: MassMono: "87.055838" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00901 ! modified L-alanine residue + +[Term] +id: MOD:00091 +name: L-arginine amide +def: "A protein modification that effectively converts an L-arginine residue to L-arginine amide." [PubMed:2229025, PubMed:2753890, PubMed:743209, RESID:AA0082] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide" EXACT RESID-systematic [] +synonym: "2-amino-5-carbamimidamidopentanamide" EXACT RESID-alternate [] +synonym: "2-amino-5-guanidinopentanamide" EXACT RESID-alternate [] +synonym: "amidated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "argininamide" EXACT RESID-alternate [] +synonym: "ArgN" EXACT PSI-MOD-label [] +synonym: "L-arginine amide" EXACT RESID-name [] +synonym: "MOD_RES Arginine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 6 H 14 N 5 O 1" +xref: MassAvg: "172.21" +xref: MassMono: "172.119835" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00092 +name: L-asparagine amide +def: "A protein modification that effectively converts an L-asparagine residue to L-asparagine amide." [PubMed:2753132, PubMed:279902, PubMed:3415690, RESID:AA0083] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminobutanediamide" EXACT RESID-systematic [] +synonym: "amidated L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "AsnN" EXACT PSI-MOD-label [] +synonym: "asparaginamide" EXACT RESID-alternate [] +synonym: "L-asparagine amide" EXACT RESID-name [] +synonym: "MOD_RES Asparagine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 4 H 8 N 3 O 2" +xref: MassAvg: "130.13" +xref: MassMono: "130.061652" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00093 +name: L-aspartic acid 1-amide +def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide." [PubMed:2542051, RESID:AA0084] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-1-butanediamic acid" EXACT RESID-systematic [] +synonym: "1-amidated L-aspartic acid" EXACT PSI-MOD-alternate [] +synonym: "3,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "3-amino-succinamic acid" EXACT RESID-alternate [] +synonym: "alpha-asparagine" EXACT RESID-alternate [] +synonym: "AspN" EXACT PSI-MOD-label [] +synonym: "isoasparagine" EXACT RESID-alternate [] +synonym: "L-aspartic acid 1-amide" EXACT RESID-name [] +synonym: "MOD_RES Aspartic acid 1-amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 4 H 7 N 2 O 3" +xref: MassAvg: "131.11" +xref: MassMono: "131.045667" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:00094 +name: L-cysteine amide +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine amide." [PubMed:1892838, PubMed:7149738, RESID:AA0085] +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-sulfanylpropanamide" EXACT RESID-systematic [] +synonym: "2-amino-3-mercaptopropanamide" EXACT RESID-alternate [] +synonym: "amidated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "CysN" EXACT PSI-MOD-label [] +synonym: "cysteinamide" EXACT RESID-alternate [] +synonym: "L-cysteine amide" EXACT RESID-name [] +synonym: "MOD_RES Cysteine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1 S 0" +xref: DiffMono: "-0.984016" +xref: Formula: "C 3 H 7 N 2 O 1 S 1" +xref: MassAvg: "119.16" +xref: MassMono: "119.027909" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00095 +name: L-glutamine amide +def: "A protein modification that effectively converts an L-glutamine residue to L-glutamine amide." [PubMed:7673220, PubMed:9048550, RESID:AA0086] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminopentanediamide" EXACT RESID-systematic [] +synonym: "amidated L-glutamine" EXACT PSI-MOD-alternate [] +synonym: "GlnN" EXACT PSI-MOD-label [] +synonym: "glutaminamide" EXACT RESID-alternate [] +synonym: "L-glutamine amide" EXACT RESID-name [] +synonym: "MOD_RES Glutamine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 5 H 10 N 3 O 2" +xref: MassAvg: "144.15" +xref: MassMono: "144.077302" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:00096 +name: L-glutamic acid 1-amide +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide." [PubMed:1093875, PubMed:14550575, RESID:AA0087] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-1-pentanediamic acid" EXACT RESID-systematic [] +synonym: "1-amidated L-glutamic acid" EXACT PSI-MOD-alternate [] +synonym: "4,5-diamino-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "GluN" EXACT PSI-MOD-label [] +synonym: "isoglutamine" EXACT RESID-alternate [] +synonym: "L-glutamic acid 1-amide" EXACT RESID-name [] +synonym: "MOD_RES Glutamic acid 1-amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 5 H 9 N 2 O 3" +xref: MassAvg: "145.14" +xref: MassMono: "145.061317" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00097 +name: glycine amide +def: "A protein modification that effectively converts a glycine residue to glycine amide." [PubMed:13591312, RESID:AA0088] +subset: PSI-MOD-slim +synonym: "2-aminoacetamide" EXACT RESID-alternate [] +synonym: "2-aminoethanamide" EXACT RESID-systematic [] +synonym: "2-azanylethanamide" EXACT RESID-alternate [] +synonym: "amidated glycine" EXACT PSI-MOD-alternate [] +synonym: "glycinamide" EXACT RESID-alternate [] +synonym: "glycine amide" EXACT RESID-name [] +synonym: "GlyN" EXACT PSI-MOD-label [] +synonym: "MOD_RES Glycine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 2 H 5 N 2 O 1" +xref: MassAvg: "73.07" +xref: MassMono: "73.040188" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:00098 +name: L-histidine amide +def: "A protein modification that effectively converts an L-histidine residue to L-histidine amide." [PubMed:2153586, PubMed:2307683, PubMed:2839478, RESID:AA0089] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanamide" EXACT RESID-systematic [] +synonym: "amidated L-histidine" EXACT PSI-MOD-alternate [] +synonym: "HisN" EXACT PSI-MOD-label [] +synonym: "histidinamide" EXACT RESID-alternate [] +synonym: "L-histidine amide" EXACT RESID-name [] +synonym: "MOD_RES Histidine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 6 H 9 N 4 O 1" +xref: MassAvg: "153.16" +xref: MassMono: "153.077636" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00099 +name: L-isoleucine amide +def: "A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide." [RESID:AA0090] +subset: PSI-MOD-slim +synonym: "(2S,3S)-2-amino-3-methylpentanamide" EXACT RESID-systematic [] +synonym: "amidated L-isoleucine" EXACT PSI-MOD-alternate [] +synonym: "IleN" EXACT PSI-MOD-label [] +synonym: "isoleucinamide" EXACT RESID-alternate [] +synonym: "L-isoleucine amide" EXACT RESID-name [] +synonym: "MOD_RES Isoleucine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 6 H 13 N 2 O 1" +xref: MassAvg: "129.18" +xref: MassMono: "129.102788" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00910 ! modified L-isoleucine residue + +[Term] +id: MOD:00100 +name: L-leucine amide +def: "A protein modification that effectively converts an L-leucine residue to L-leucine amide." [PubMed:2578459, RESID:AA0091] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-methylpentanamide" EXACT RESID-systematic [] +synonym: "2-amino-4-methylvaleramide" EXACT RESID-alternate [] +synonym: "2-azanyl-4-methylpentanamide" EXACT RESID-alternate [] +synonym: "alpha-aminoisocaproamide" EXACT RESID-alternate [] +synonym: "amidated L-leucine" EXACT PSI-MOD-alternate [] +synonym: "L-leucine amide" EXACT RESID-name [] +synonym: "leucinamide" EXACT RESID-alternate [] +synonym: "LeuN" EXACT PSI-MOD-label [] +synonym: "MOD_RES Leucine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 6 H 13 N 2 O 1" +xref: MassAvg: "129.18" +xref: MassMono: "129.102788" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00911 ! modified L-leucine residue + +[Term] +id: MOD:00101 +name: L-lysine amide +def: "A protein modification that effectively converts an L-lysine residue to L-lysine amide." [PubMed:6579533, RESID:AA0092] +subset: PSI-MOD-slim +synonym: "(2S)-2,6-diaminohexanamide" EXACT RESID-systematic [] +synonym: "amidated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "L-lysine amide" EXACT RESID-name [] +synonym: "lysinamide" EXACT RESID-alternate [] +synonym: "LysN" EXACT PSI-MOD-label [] +synonym: "MOD_RES Lysine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 6 H 14 N 3 O 1" +xref: MassAvg: "144.20" +xref: MassMono: "144.113687" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00102 +name: L-methionine amide +def: "A protein modification that effectively converts an L-methionine residue to L-methionine amide." [PubMed:4375977, RESID:AA0093] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-(methylsulfanyl)butanamide" EXACT RESID-systematic [] +synonym: "2-amino-4-(methylthio)butanamide" EXACT RESID-alternate [] +synonym: "amidated L-methionine" EXACT PSI-MOD-alternate [] +synonym: "L-methionine amide" EXACT RESID-name [] +synonym: "methioninamide" EXACT RESID-alternate [] +synonym: "MetN" EXACT PSI-MOD-label [] +synonym: "MOD_RES Methionine amide" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1 S 0" +xref: DiffMono: "-0.984016" +xref: Formula: "C 5 H 11 N 2 O 1 S 1" +xref: MassAvg: "147.22" +xref: MassMono: "147.059209" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00103 +name: L-phenylalanine amide +def: "A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide." [PubMed:2905621, PubMed:8868490, RESID:AA0094] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-phenylpropanamide" EXACT RESID-systematic [] +synonym: "amidated L-phenylalanine" EXACT PSI-MOD-alternate [] +synonym: "L-phenylalanine amide" EXACT RESID-name [] +synonym: "MOD_RES Phenylalanine amide" EXACT UniProt-feature [] +synonym: "PheN" EXACT PSI-MOD-label [] +synonym: "phenylalaninamide" EXACT RESID-alternate [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 9 H 11 N 2 O 1" +xref: MassAvg: "163.20" +xref: MassMono: "163.087138" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:00104 +name: L-proline amide +def: "A protein modification that effectively converts an L-proline residue to L-proline amide." [PubMed:4982117, PubMed:5760861, RESID:AA0095] +subset: PSI-MOD-slim +synonym: "(2S)-pyrrolidine-2-carboxamide" EXACT RESID-systematic [] +synonym: "amidated L-proline" EXACT PSI-MOD-alternate [] +synonym: "L-proline amide" EXACT RESID-name [] +synonym: "MOD_RES Proline amide" EXACT UniProt-feature [] +synonym: "prolinamide" EXACT RESID-alternate [] +synonym: "ProN" EXACT PSI-MOD-label [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 5 H 9 N 2 O 1" +xref: MassAvg: "113.14" +xref: MassMono: "113.071488" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00105 +name: L-serine amide +def: "A protein modification that effectively converts an L-serine residue to L-serine amide." [PubMed:743209, RESID:AA0096] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-hydroxypropanamide" EXACT RESID-systematic [] +synonym: "amidated L-serine" EXACT PSI-MOD-alternate [] +synonym: "L-serine amide" EXACT RESID-name [] +synonym: "MOD_RES Serine amide" EXACT UniProt-feature [] +synonym: "serinamide" EXACT RESID-alternate [] +synonym: "SerN" EXACT PSI-MOD-label [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 3 H 7 N 2 O 2" +xref: MassAvg: "103.10" +xref: MassMono: "103.050752" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00106 +name: L-threonine amide +def: "A protein modification that effectively converts an L-threonine residue to L-threonine amide." [PubMed:1390774, RESID:AA0097] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-hydroxybutanamide" EXACT RESID-systematic [] +synonym: "amidated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "L-threonine amide" EXACT RESID-name [] +synonym: "MOD_RES Threonine amide" EXACT UniProt-feature [] +synonym: "threoninamide" EXACT RESID-alternate [] +synonym: "ThrN" EXACT PSI-MOD-label [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 4 H 9 N 2 O 2" +xref: MassAvg: "117.13" +xref: MassMono: "117.066403" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00107 +name: L-tryptophan amide +def: "A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide." [PubMed:3947348, RESID:AA0098] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanamide" EXACT RESID-systematic [] +synonym: "amidated L-tryptophan" EXACT PSI-MOD-alternate [] +synonym: "L-tryptophan amide" EXACT RESID-name [] +synonym: "MOD_RES Tryptophan amide" EXACT UniProt-feature [] +synonym: "TrpN" EXACT PSI-MOD-label [] +synonym: "tryptophanamide" EXACT RESID-alternate [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 11 H 12 N 3 O 1" +xref: MassAvg: "202.24" +xref: MassMono: "202.098037" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00108 +name: L-tyrosine amide +def: "A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide." [PubMed:1377792, PubMed:3562898, PubMed:6509012, RESID:AA0099] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-hydoxyphenyl)propanamide" EXACT RESID-systematic [] +synonym: "amidated L-tyrosine" EXACT PSI-MOD-alternate [] +synonym: "L-tyrosine amide" EXACT RESID-name [] +synonym: "MOD_RES Tyrosine amide" EXACT UniProt-feature [] +synonym: "TyrN" EXACT PSI-MOD-label [] +synonym: "tyrosinamide" EXACT RESID-alternate [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 9 H 11 N 2 O 2" +xref: MassAvg: "179.20" +xref: MassMono: "179.082053" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00109 +name: L-valine amide +def: "A protein modification that effectively converts an L-valine residue to L-valine amide." [PubMed:2578459, PubMed:5465996, RESID:AA0100] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-methylbutanamide" EXACT RESID-systematic [] +synonym: "L-valine amide" EXACT RESID-name [] +synonym: "MOD_RES Valine amide" EXACT UniProt-feature [] +synonym: "valinamide" EXACT RESID-alternate [] +synonym: "ValN" EXACT PSI-MOD-label [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 5 H 11 N 2 O 1" +xref: MassAvg: "115.16" +xref: MassMono: "115.087138" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00883 ! C1-amidated residue +is_a: MOD:00920 ! modified L-valine residue + +[Term] +id: MOD:00110 +name: L-cysteine methyl disulfide +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide." [OMSSA:179, PubMed:10555576, PubMed:163643, PubMed:2056535, PubMed:6381494, RESID:AA0101, UniMod:39#C] +comment: Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG]. +synonym: "(2R)-2-amino-3-(methyldisulfanediyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(methyldisulfanediyl)propanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-(methyldithio)propanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-methyldisulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-(methyldisulfanediyl)-propanoic acid" EXACT RESID-alternate [] +synonym: "Beta-methylthiolation" RELATED UniMod-description [] +synonym: "L-3-(methyldithio)alanine" EXACT RESID-alternate [] +synonym: "L-cysteine methyl disulfide" EXACT RESID-name [] +synonym: "methyl methanethiolsulfonate derivatized cysteine" EXACT PSI-MOD-alternate [] +synonym: "methyl methanethiosulfonate derivatized cysteine" EXACT PSI-MOD-alternate [] +synonym: "Methylthio" RELATED PSI-MS-label [] +synonym: "Methylthio" RELATED UniMod-interim [] +synonym: "mmts" EXACT OMSSA-label [] +synonym: "MOD_RES Cysteine methyl disulfide" EXACT UniProt-feature [] +synonym: "S-methylthio-L-cysteine" EXACT RESID-alternate [] +synonym: "S-methylthiocysteine" EXACT RESID-alternate [] +xref: DiffAvg: "46.09" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" +xref: DiffMono: "45.987721" +xref: Formula: "C 4 H 7 N 1 O 1 S 2" +xref: MassAvg: "149.23" +xref: MassMono: "148.996906" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01153 ! methylthiolated residue +is_a: MOD:01862 ! disulfide conjugated residue + +[Term] +id: MOD:00111 +name: S-farnesyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine." [DeltaMass:293, OMSSA:42, PubMed:1409665, PubMed:15609361, PubMed:1872463, PubMed:2684976, RESID:AA0102, UniMod:44#C] +comment: From DeltaMass: (name misspelled "S-farnesyl cystenyl") +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "Farnesyl" RELATED PSI-MS-label [] +synonym: "Farnesylation" RELATED UniMod-description [] +synonym: "farnesylationc" EXACT OMSSA-label [] +synonym: "LIPID S-farnesyl cysteine" EXACT UniProt-feature [] +synonym: "S-farnesyl Cystenyl" EXACT DeltaMass-label [] +synonym: "S-farnesyl-L-cysteine" EXACT RESID-name [] +synonym: "SFarnCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "204.36" +xref: DiffFormula: "C 15 H 24 N 0 O 0 S 0" +xref: DiffMono: "204.187801" +xref: Formula: "C 18 H 29 N 1 O 1 S 1" +xref: MassAvg: "307.50" +xref: MassMono: "307.196986" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00437 ! farnesylated residue +is_a: MOD:01110 ! isoprenylated cysteine + +[Term] +id: MOD:00112 +name: S-12-hydroxyfarnesyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine." [PubMed:17790543, RESID:AA0103, UniMod:376] +synonym: "(2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "Hydroxyfarnesyl" RELATED PSI-MS-label [] +synonym: "hydroxyfarnesyl" RELATED UniMod-description [] +synonym: "LIPID S-12-hydroxyfarnesyl cysteine" EXACT UniProt-feature [] +synonym: "S-12-hydroxyfarnesyl-L-cysteine" EXACT RESID-name [] +synonym: "S12HyFarnCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "220.36" +xref: DiffFormula: "C 15 H 24 N 0 O 1 S 0" +xref: DiffMono: "220.182715" +xref: Formula: "C 18 H 29 N 1 O 2 S 1" +xref: MassAvg: "323.50" +xref: MassMono: "323.191900" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01110 ! isoprenylated cysteine + +[Term] +id: MOD:00113 +name: S-geranylgeranyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine." [DeltaMass:0, OMSSA:49, PubMed:1483450, PubMed:15609361, RESID:AA0104, UniMod:48#C] +comment: DeltaMass calculates the mass with two double bonds rather than four +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "Geranyl-geranyl" RELATED UniMod-description [] +synonym: "GeranylGeranyl" RELATED PSI-MS-label [] +synonym: "geranylgeranylc" EXACT OMSSA-label [] +synonym: "LIPID S-geranylgeranyl cysteine" EXACT UniProt-feature [] +synonym: "S-geranylgeranyl" EXACT DeltaMass-label [] +synonym: "S-geranylgeranyl-L-cysteine" EXACT RESID-name [] +synonym: "SGergerCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "272.48" +xref: DiffFormula: "C 20 H 32 N 0 O 0 S 0" +xref: DiffMono: "272.250401" +xref: Formula: "C 23 H 37 N 1 O 1 S 1" +xref: MassAvg: "375.62" +xref: MassMono: "375.259586" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00441 ! geranylgeranylated residue +is_a: MOD:01110 ! isoprenylated cysteine + +[Term] +id: MOD:00114 +name: L-cysteine methyl ester +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester." [PubMed:11875433, PubMed:1872463, RESID:AA0105, UniMod:34#C-term] +comment: Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. +subset: PSI-MOD-slim +synonym: "2-amino-3-mercaptopropanoic methyl ester" EXACT RESID-alternate [] +synonym: "2-amino-3-sulfanylpropanoic methyl ester" EXACT RESID-alternate [] +synonym: "L-cysteine methyl ester" EXACT RESID-name [] +synonym: "mecysteine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] +synonym: "methyl esterified L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "methyl L-cysteinate" EXACT RESID-alternate [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES Cysteine methyl ester" EXACT UniProt-feature [] +synonym: "OMeCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 4 H 8 N 1 O 2 S 1" +xref: MassAvg: "134.17" +xref: MassMono: "134.027574" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01682 ! monomethylated L-cysteine +is_a: MOD:01689 ! alpha-carboxyl methylated residue + +[Term] +id: MOD:00115 +name: S-palmitoyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine." [DeltaMass:303, PubMed:1872406, PubMed:3166978, PubMed:8180229, PubMed:8824274, RESID:AA0106, UniMod:47#C] +comment: From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556 +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(hexadecanoylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE S-palmitoyl cysteine intermediate" EXACT UniProt-feature [] +synonym: "cysteine hexadecanoate thioester" EXACT RESID-alternate [] +synonym: "cysteine palmitate thioester" EXACT RESID-alternate [] +synonym: "LIPID S-palmitoyl cysteine" EXACT UniProt-feature [] +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +synonym: "S-palmitoyl-L-cysteine" EXACT RESID-name [] +synonym: "S-palmitoylated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-palmityl Cystenyl" EXACT DeltaMass-label [] +synonym: "SPamCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "C 19 H 35 N 1 O 2 S 1" +xref: MassAvg: "341.55" +xref: MassMono: "341.238850" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00653 ! S-palmitoylated residue +is_a: MOD:01684 ! palmitoylated-L-cysteine + +[Term] +id: MOD:00116 +name: S-diacylglycerol-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107, UniMod:377#C] +comment: Incidental to RESID:AA0060. +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid" EXACT RESID-alternate [] +synonym: "Diacylglycerol" RELATED PSI-MS-label [] +synonym: "diacylglycerol" RELATED UniMod-description [] +synonym: "LIPID S-diacylglycerol cysteine" EXACT UniProt-feature [] +synonym: "S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine" EXACT RESID-alternate [] +synonym: "S-(2',3'-diacylglycerol)-L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-diacylglycerol-L-cysteine" EXACT RESID-name [] +synonym: "SAcyl2GlyceroCys" EXACT PSI-MOD-label [] +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00117 +name: S-(L-isoglutamyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia." [ChEBI:22021, DeltaMass:0, PubMed:6838833, RESID:AA0108] +comment: Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln)" EXACT UniProt-feature [] +synonym: "gamma-(S-cysteinyl)glutamic acid" EXACT RESID-alternate [] +synonym: "S-(L-isoglutamyl)-L-cysteine" EXACT RESID-name [] +synonym: "S-gamma-glutamyl (crosslinked to cysteine)" EXACT DeltaMass-label [] +synonym: "XLNK-SCys-5Glu(Gln)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 8 H 10 N 2 O 3 S 1" +xref: MassAvg: "214.24" +xref: MassMono: "214.041213" +xref: Origin: "C, Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia + +[Term] +id: MOD:00118 +name: 2'-(S-L-cysteinyl)-L-histidine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine." [DeltaMass:0, PubMed:6210696, RESID:AA0109] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-alternate [] +synonym: "2'-(L-cystein-S-yl)-L-histidine" EXACT RESID-name [] +synonym: "CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His)" EXACT UniProt-feature [] +synonym: "S-(2'-histidyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(2-histidyl)- (crosslinked to cysteine)" EXACT DeltaMass-label [] +synonym: "XLNK-SCys-2'His" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 9 H 10 N 4 O 2 S 1" +xref: MassAvg: "238.26" +xref: MassMono: "238.052447" +xref: Origin: "C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00119 +name: L-lanthionine (Cys-Ser) +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine." [ChEBI:21347, DeltaMass:7, RESID:AA0110#CSX] +comment: Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG]. +synonym: "(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "(R)-S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT RESID-alternate [] +synonym: "(R,R)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "(R,R)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "(R,R)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate [] +synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "3,3'-thiobis-L-alanine" EXACT RESID-alternate [] +synonym: "L-lanthionine" EXACT RESID-name [] +synonym: "XLNK-SCys-(L)3Dha" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "C, S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01839 ! L-lanthionine + +[Term] +id: MOD:00120 +name: meso-lanthionine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine." [PubMed:15023056, PubMed:3769923, RESID:AA0111] +comment: Cross-link 2. +synonym: "(2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "(2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "(2R,6S)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "(2R,6S)-meso-lanthionine" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid" EXACT RESID-alternate [] +synonym: "(2S,6R)-meso-lanthionine" RELATED RESID-misnomer [] +synonym: "(R)-S-(2-amino-2-carboxyethyl)-D-cysteine" EXACT RESID-alternate [] +synonym: "(R,S)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate [] +synonym: "3,3'-thiobis-meso-alanine" EXACT RESID-alternate [] +synonym: "CROSSLNK Lanthionine (Cys-Ser)" EXACT UniProt-feature [] +synonym: "CROSSLNK Lanthionine (Ser-Cys)" EXACT UniProt-feature [] +synonym: "cysteine-3-D-alanine thioether" EXACT RESID-alternate [] +synonym: "meso-lanthionine" EXACT RESID-name [] +synonym: "XLNK-SCys-(D)3Dha" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01841 ! lanthionine + +[Term] +id: MOD:00121 +name: (2S,3S,2'R)-3-methyllanthionine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine." [PubMed:3769923, RESID:AA0112] +comment: Cross-link 2. +synonym: "(2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate [] +synonym: "(2S,3S,2'R)-3-methyllanthionine" EXACT RESID-name [] +synonym: "(2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "(2S,3S,6R)-3-methyllanthionine" EXACT RESID-alternate [] +synonym: "(2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate [] +synonym: "3-methyl-D,L-lanthionine" EXACT RESID-alternate [] +synonym: "CROSSLNK Beta-methyllanthionine (Cys-Thr)" EXACT UniProt-feature [] +synonym: "CROSSLNK Beta-methyllanthionine (Thr-Cys)" EXACT UniProt-feature [] +synonym: "cysteine-3-D-butyrine thioether" EXACT RESID-alternate [] +synonym: "XLNK-SCys-3Dhb" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 10 N 2 O 2 S 1" +xref: MassAvg: "186.23" +xref: MassMono: "186.046299" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01981 ! 3-methyllanthionine + +[Term] +id: MOD:00122 +name: 3'-(S-L-cysteinyl)-L-tyrosine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine." [DeltaMass:0, PubMed:15917234, PubMed:2002850, RESID:AA0113] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid" EXACT RESID-alternate [] +synonym: "3'-(cystein-S-yl)tyrosine" EXACT RESID-alternate [] +synonym: "3'-(L-cystein-S-yl)-L-tyrosine" EXACT RESID-name [] +synonym: "CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" EXACT UniProt-feature [] +synonym: "CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys)" EXACT UniProt-feature [] +synonym: "S-(3-Tyr) (Crosslinked to Cysteine)" EXACT DeltaMass-label [] +synonym: "S-(tyros-3'-yl)cysteine" EXACT RESID-alternate [] +synonym: "XLNK-SCys-3'Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 12 H 12 N 2 O 3 S 1" +xref: MassAvg: "264.30" +xref: MassMono: "264.056863" +xref: Origin: "C, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00123 +name: N6-carboxy-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine." [PubMed:11369851, PubMed:4436319, PubMed:637859, PubMed:7754395, RESID:AA0114, UniMod:299#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(carboxyamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-6-carbamic hexanoic acid" EXACT RESID-alternate [] +synonym: "Carboxy" RELATED UniMod-interim [] +synonym: "Carboxylation" RELATED UniMod-description [] +synonym: "lysine NZ-carboxylic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N6-carboxylysine" EXACT UniProt-feature [] +synonym: "N6-carbamyllysine" RELATED RESID-misnomer [] +synonym: "N6-carboxy-L-lysine" EXACT RESID-name [] +synonym: "N6-carboxylysine" EXACT RESID-alternate [] +synonym: "N6CbxLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "C 7 H 12 N 2 O 3" +xref: MassAvg: "172.18" +xref: MassMono: "172.084792" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:00124 +name: N6-1-carboxyethyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine." [PubMed:3123486, PubMed:8253186, PubMed:8421682, RESID:AA0115, UniMod:378#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "Carboxyethyl" RELATED PSI-MS-label [] +synonym: "carboxyethyl" RELATED UniMod-description [] +synonym: "MOD_RES N6-1-carboxyethyl lysine" EXACT UniProt-feature [] +synonym: "N6-(1-carboxyethyl)-L-lysine" EXACT RESID-name [] +synonym: "N6-(1-carboxyethyl)lysine" EXACT RESID-alternate [] +synonym: "N6CbzEtLys" EXACT PSI-MOD-label [] +synonym: "NZ-(1-carboxyethyl)lysine" EXACT RESID-alternate [] +xref: DiffAvg: "72.06" +xref: DiffFormula: "C 3 H 4 N 0 O 2" +xref: DiffMono: "72.021129" +xref: Formula: "C 9 H 16 N 2 O 3" +xref: MassAvg: "200.24" +xref: MassMono: "200.116092" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00125 +name: hypusine +def: "A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [DeltaMass:0, PubMed:6806267, PubMed:8108861, RESID:AA0116, UniMod:379#K] +comment: This modification occurs uniquely in translation initiation factor eIF-5A [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "(2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid" EXACT RESID-alternate [] +synonym: "(2S,9R)-hypusine" EXACT RESID-alternate [] +synonym: "2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid" EXACT RESID-alternate [] +synonym: "Hypu" EXACT PSI-MOD-label [] +synonym: "Hypusine" RELATED PSI-MS-label [] +synonym: "hypusine" RELATED UniMod-description [] +synonym: "L-hypusine" EXACT RESID-name [] +synonym: "MOD_RES Hypusine" EXACT UniProt-feature [] +synonym: "N-(4-NH2-2-OH-butyl)- (of Lysine)" EXACT DeltaMass-label [] +synonym: "N6-(4-amino-2-hydroxybutyl)-L-lysine" EXACT RESID-alternate [] +xref: DiffAvg: "87.12" +xref: DiffFormula: "C 4 H 9 N 1 O 1" +xref: DiffMono: "87.068414" +xref: Formula: "C 10 H 21 N 3 O 2" +xref: MassAvg: "215.30" +xref: MassMono: "215.163377" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01884 ! 4-aminobutylated residue +relationship: derives_from MOD:01880 ! L-deoxyhypusine + +[Term] +id: MOD:00126 +name: N6-biotinyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine." [DeltaMass:305, PubMed:16109483, PubMed:3178228, PubMed:7948875, PubMed:8747466, RESID:AA0117, UniMod:3#K] +comment: From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "(3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine" EXACT RESID-alternate [] +synonym: "biocytin" EXACT RESID-alternate [] +synonym: "Biotin" RELATED PSI-MS-label [] +synonym: "biotinyl lysyl" EXACT DeltaMass-label [] +synonym: "Biotinylation" RELATED UniMod-description [] +synonym: "epsilon-N-biotinyllysine" EXACT RESID-alternate [] +synonym: "MOD_RES N6-biotinyllysine" EXACT UniProt-feature [] +synonym: "N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine" EXACT RESID-alternate [] +synonym: "N6-biotinyl-L-lysine" EXACT RESID-name [] +synonym: "N6-biotinyllysine" EXACT RESID-alternate [] +synonym: "N6BtnLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "226.29" +xref: DiffFormula: "C 10 H 14 N 2 O 2 S 1" +xref: DiffMono: "226.077599" +xref: Formula: "C 16 H 26 N 4 O 3 S 1" +xref: MassAvg: "354.47" +xref: MassMono: "354.172562" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine +is_a: MOD:01885 ! biotinylated residue + +[Term] +id: MOD:00127 +name: N6-lipoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine." [DeltaMass:0, OMSSA:67, PubMed:3421911, PubMed:3522581, PubMed:7719855, RESID:AA0118, UniMod:42#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid" EXACT RESID-systematic [] +synonym: "(2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid" EXACT RESID-alternate [] +synonym: "Lipoyl" RELATED PSI-MS-label [] +synonym: "Lipoyl" RELATED UniMod-description [] +synonym: "lipoylk" EXACT OMSSA-label [] +synonym: "MOD_RES N6-lipoyllysine" EXACT UniProt-feature [] +synonym: "N-Lipoyl- (on Lysine)" EXACT DeltaMass-label [] +synonym: "N6-6,8-dithiooctanoyllysine" EXACT RESID-alternate [] +synonym: "N6-lipoyl-L-lysine" EXACT RESID-name [] +synonym: "N6-lipoyllysine" EXACT RESID-alternate [] +synonym: "N6LipLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "188.30" +xref: DiffFormula: "C 8 H 12 N 0 O 1 S 2" +xref: DiffMono: "188.032957" +xref: Formula: "C 14 H 24 N 2 O 2 S 2" +xref: MassAvg: "316.48" +xref: MassMono: "316.127920" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00128 +name: N6-pyridoxal phosphate-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine." [DeltaMass:0, PubMed:1544460, RESID:AA0119, UniMod:46#K] +comment: From DeltaMass: Average Mass: 231 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N6-(pyridoxal phosphate)lysine" EXACT UniProt-feature [] +synonym: "N6-pyridoxal phosphate-L-lysine" EXACT RESID-name [] +synonym: "N6PydoxLys" EXACT PSI-MOD-label [] +synonym: "Pyridoxal phosphate" RELATED UniMod-description [] +synonym: "Pyridoxal phosphate (Schiff Base formed to lysine)" EXACT DeltaMass-label [] +synonym: "PyridoxalPhosphate" RELATED PSI-MS-label [] +xref: DiffAvg: "229.13" +xref: DiffFormula: "C 8 H 8 N 1 O 5 P 1" +xref: DiffMono: "229.014009" +xref: Formula: "C 14 H 20 N 3 O 6 P 1" +xref: MassAvg: "357.30" +xref: MassMono: "357.108972" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00129 +name: N6-retinylidene-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal." [PubMed:6794028, PubMed:6870827, RESID:AA0120, UniMod:380#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N6-(retinylidene)lysine" EXACT UniProt-feature [] +synonym: "N6-retinal-L-lysine" EXACT RESID-alternate [] +synonym: "N6-retinyl-lysine" EXACT RESID-alternate [] +synonym: "N6-retinylidene-L-lysine" EXACT RESID-name [] +synonym: "N6RetalLys" EXACT PSI-MOD-label [] +synonym: "retinal" RELATED UniMod-description [] +synonym: "Retinylidene" RELATED PSI-MS-label [] +xref: DiffAvg: "266.43" +xref: DiffFormula: "C 20 H 26 N 0 O 0" +xref: DiffMono: "266.203451" +xref: Formula: "C 26 H 38 N 2 O 1" +xref: MassAvg: "394.60" +xref: MassMono: "394.298414" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00130 +name: L-allysine +def: "A protein modification that effectively converts an L-lysine residue to L-allysine." [ChEBI:17917, DeltaMass:0, PubMed:11120890, PubMed:11332453, PubMed:358196, PubMed:5337886, PubMed:5529814, RESID:AA0121, UniMod:352#K] +comment: From DeltaMass: Average Mass: -1 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-oxohexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-5-formylvaleric acid" EXACT RESID-alternate [] +synonym: "2-amino-adipic acid semialdahyde" EXACT RESID-alternate [] +synonym: "2-aminoadipate 6-semialdehyde" EXACT RESID-alternate [] +synonym: "5-formyl-norvaline" EXACT RESID-alternate [] +synonym: "6-oxonorleucine" EXACT RESID-alternate [] +synonym: "AASA" EXACT RESID-alternate [] +synonym: "Allysine (from Lysine)" EXACT DeltaMass-label [] +synonym: "alpha-amino-adipic acid delta-semialdahyde" EXACT RESID-alternate [] +synonym: "L-allysine" EXACT RESID-name [] +synonym: "Lys->Allysine" RELATED PSI-MS-label [] +synonym: "Lysal" EXACT PSI-MOD-label [] +synonym: "Lysine oxidation to aminoadipic semialdehyde" RELATED UniMod-description [] +synonym: "MOD_RES Allysine" EXACT UniProt-feature [] +synonym: "Oxidation of lysine (to aminoadipic semialdehyde)" EXACT DeltaMass-label [] +xref: DiffAvg: "-1.03" +xref: DiffFormula: "C 0 H -3 N -1 O 1" +xref: DiffMono: "-1.031634" +xref: Formula: "C 6 H 9 N 1 O 2" +xref: MassAvg: "127.14" +xref: MassMono: "127.063329" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00131 +name: L-2-aminoadipic acid +def: "A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid." [DeltaMass:353, PubMed:336041, PubMed:358196, PubMed:7419498, RESID:AA0122, UniMod:381#K] +comment: From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminohexanedioic acid" EXACT RESID-systematic [] +synonym: "2-amino-1,4-butanedicarboxylic acid" EXACT RESID-alternate [] +synonym: "alpha-amino adipic acid" RELATED UniMod-description [] +synonym: "L-2-aminoadipic acid" EXACT RESID-name [] +synonym: "L-alpha-aminoadipic acid" EXACT RESID-alternate [] +synonym: "Lys->AminoadipicAcid" RELATED PSI-MS-label [] +synonym: "Lysoic" EXACT PSI-MOD-label [] +synonym: "Oxidation of lysine (to aminoadipic acid)" EXACT DeltaMass-label [] +xref: DiffAvg: "14.97" +xref: DiffFormula: "C 0 H -3 N -1 O 2" +xref: DiffMono: "14.963280" +xref: Formula: "C 6 H 9 N 1 O 3" +xref: MassAvg: "143.14" +xref: MassMono: "143.058243" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00132 +name: L-lysinoalanine (Lys-Ser) +def: "A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid." [DeltaMass:0, PubMed:2544544, RESID:AA0123#KSX] +comment: Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34. +synonym: "(2R,9S)-lysinoalanine" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "alaninolysine" EXACT RESID-alternate [] +synonym: "CROSSLNK Lysinoalanine (Ser-Lys)" EXACT UniProt-feature [] +synonym: "L-lysinoalanine" EXACT RESID-name [] +synonym: "LAL" EXACT RESID-alternate [] +synonym: "Lysinoalanine (from Cysteine)" EXACT DeltaMass-label [] +synonym: "N-epsilon-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] +synonym: "XLNK-N6Lys-3Dha(Ser)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 9 H 15 N 3 O 2" +xref: MassAvg: "197.24" +xref: MassMono: "197.116427" +xref: Origin: "K, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01853 ! L-lysinoalanine + +[Term] +id: MOD:00133 +name: N6-(L-isoglutamyl)-L-lysine (Gln) +def: "A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia." [ChEBI:21863, DeltaMass:0, PubMed:2461365, PubMed:5637041, PubMed:5656070, PubMed:8598899, RESID:AA0124#GLN] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate [] +synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln)" EXACT UniProt-feature [] +synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label [] +synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate [] +synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] +synonym: "XLNK-N6Lys-5Glu(Gln)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 11 H 17 N 3 O 3" +xref: MassAvg: "239.27" +xref: MassMono: "239.126991" +xref: Origin: "K, Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia +is_a: MOD:01630 ! N6-(L-isoglutamyl)-L-lysine + +[Term] +id: MOD:00134 +name: N6-glycyl-L-lysine +def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine." [ChEBI:21885, RESID:AA0125] +comment: Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid" EXACT RESID-systematic [] +synonym: "N6-(glycyl)-L-lysine" EXACT RESID-name [] +synonym: "N6-glycyllysine" EXACT RESID-alternate [] +synonym: "XLNK-N6Lys-1Gly" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 8 H 14 N 3 O 2" +xref: MassAvg: "184.22" +xref: MassMono: "184.108602" +xref: Origin: "G, K" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00135 +name: N-(L-isoaspartyl)-glycine (Asn) +def: "A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia." [ChEBI:21479, PubMed:1826288, RESID:AA0126] +comment: Cross-link 2. +synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly)" EXACT UniProt-feature [] +synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn)" EXACT UniProt-feature [] +synonym: "isoaspartyl glycine" EXACT RESID-alternate [] +synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name [] +synonym: "N-beta-aspartylglycine" EXACT RESID-alternate [] +synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate [] +synonym: "XLNK-4Asp-NGly(Asn)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 6 H 7 N 2 O 3" +xref: MassAvg: "155.13" +xref: MassMono: "155.045667" +xref: Origin: "G, N" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia +is_a: MOD:01928 ! N-(L-isoaspartyl)-glycine + +[Term] +id: MOD:00136 +name: pyruvic acid (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127#CYS, UniMod:382] +subset: PSI-MOD-slim +synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES Pyruvic acid (Cys)" EXACT UniProt-feature [] +synonym: "Pyruv(Cys)" EXACT PSI-MOD-label [] +synonym: "pyruvic acid" EXACT RESID-name [] +xref: DiffAvg: "-33.09" +xref: DiffFormula: "C 0 H -3 N -1 O 1 S -1" +xref: DiffMono: "-33.003705" +xref: Formula: "C 3 H 3 O 2" +xref: MassAvg: "71.06" +xref: MassMono: "71.013304" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01154 ! pyruvic acid + +[Term] +id: MOD:00137 +name: L-3-phenyllactic acid +def: "A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid." [PubMed:1973541, RESID:AA0128, UniMod:7#F] +comment: This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group. +synonym: "(2S)-2-hydroxy-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "Deamidated" RELATED UniMod-interim [] +synonym: "Deamidation" RELATED UniMod-description [] +synonym: "L-3-phenyllactic acid" EXACT RESID-name [] +synonym: "MOD_RES 3-phenyllactic acid" EXACT UniProt-feature [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "C 0 H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "C 9 H 9 O 2" +xref: MassAvg: "149.17" +xref: MassMono: "149.060255" +xref: Origin: "F" +xref: TermSpec: "N-term" +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:00138 +name: 2-oxobutanoic acid +def: "A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid." [PubMed:15023056, PubMed:1680314, PubMed:2253617, PubMed:2764678, RESID:AA0129, UniMod:385#T] +synonym: "2-ketobutyric acid" EXACT RESID-alternate [] +synonym: "2-oxobutanoic acid" EXACT RESID-name [] +synonym: "2-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-oxobutyric acid" EXACT RESID-alternate [] +synonym: "Ammonia-loss" RELATED UniMod-interim [] +synonym: "Loss of ammonia" RELATED UniMod-description [] +synonym: "MOD_RES 2-oxobutanoic acid" EXACT UniProt-feature [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 4 H 5 O 2" +xref: MassAvg: "85.08" +xref: MassMono: "85.028954" +xref: Origin: "T" +xref: TermSpec: "N-term" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01160 ! deaminated residue + +[Term] +id: MOD:00139 +name: N2-succinyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan." [PubMed:11857757, PubMed:12175151, PubMed:8471040, RESID:AA0130, UniMod:64#N-term] +synonym: "(2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N2-succinyltryptophan" EXACT UniProt-feature [] +synonym: "N2-succinyl-L-tryptophan" EXACT RESID-name [] +synonym: "Succinic anhydride labeling reagent light form (N-term)" RELATED UniMod-description [] +synonym: "Succinyl" RELATED PSI-MS-label [] +xref: DiffAvg: "100.07" +xref: DiffFormula: "C 4 H 4 N 0 O 3" +xref: DiffMono: "100.016044" +xref: Formula: "C 15 H 15 N 2 O 4" +xref: MassAvg: "287.29" +xref: MassMono: "287.103182" +xref: Origin: "W" +xref: TermSpec: "N-term" +is_a: MOD:00457 ! alpha-amino succinylated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00140 +name: S-phycocyanobilin-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin." [ChEBI:15617, DeltaMass:0, PubMed:16644722, PubMed:3208761, PubMed:3838747, PubMed:7918400, RESID:AA0131, UniMod:387#C] +comment: From DeltaMass: Average Mass: 587. +synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate [] +synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] +synonym: "BINDING Phycocyanobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "PCB" EXACT RESID-alternate [] +synonym: "phycobilin cysteine" EXACT RESID-alternate [] +synonym: "Phycocyanobilin" RELATED PSI-MS-label [] +synonym: "phycocyanobilin" RELATED UniMod-description [] +synonym: "phycocyanobilin cysteine adduct" EXACT RESID-alternate [] +synonym: "S-Phycocyanobilin (on Cysteine)" EXACT DeltaMass-label [] +synonym: "S-phycocyanobilin-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "586.69" +xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" +xref: DiffMono: "586.279135" +xref: Formula: "C 36 H 43 N 5 O 7 S 1" +xref: MassAvg: "689.83" +xref: MassMono: "689.288320" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00141 +name: S-phycoerythrobilin-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin." [ChEBI:15618, PubMed:14588022, PubMed:3208761, PubMed:3838747, PubMed:8876649, RESID:AA0132, UniMod:388#C] +synonym: "(2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] +synonym: "18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate [] +synonym: "BINDING Phycoerythrobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "PEB" EXACT RESID-alternate [] +synonym: "Phycoerythrobilin" RELATED PSI-MS-label [] +synonym: "phycoerythrobilin" RELATED UniMod-description [] +synonym: "phycoerythrobilin cysteine adduct" EXACT RESID-alternate [] +synonym: "S-phycoerythrobilin-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "588.70" +xref: DiffFormula: "C 33 H 40 N 4 O 6 S 0" +xref: DiffMono: "588.294785" +xref: Formula: "C 36 H 45 N 5 O 7 S 1" +xref: MassAvg: "691.84" +xref: MassMono: "691.303970" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00142 +name: S-phytochromobilin-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin." [ChEBI:15619, PubMed:1634523, PubMed:16593380, PubMed:3208761, PubMed:7918400, RESID:AA0133, UniMod:389#C] +synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] +synonym: "18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" EXACT RESID-alternate [] +synonym: "BINDING Phytochromobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "phytochrome chromophore" EXACT RESID-alternate [] +synonym: "Phytochromobilin" RELATED PSI-MS-label [] +synonym: "phytochromobilin" RELATED UniMod-description [] +synonym: "phytochromobilin cysteine adduct" EXACT RESID-alternate [] +synonym: "S-phytochromobilin-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "584.67" +xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0" +xref: DiffMono: "584.263485" +xref: Formula: "C 36 H 41 N 5 O 7 S 1" +xref: MassAvg: "687.81" +xref: MassMono: "687.272670" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00143 +name: heme-bis-L-cysteine +def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [ChEBI:17627, PubMed:5545094, PubMed:8827449, RESID:AA0134] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "(7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate" EXACT RESID-systematic [] +synonym: "2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] +synonym: "BINDING Heme (covalent)" EXACT UniProt-feature [] +synonym: "biscysteinyl heme" EXACT RESID-alternate [] +synonym: "heme-bis-L-cysteine" EXACT RESID-name [] +synonym: "HemeCys2" EXACT PSI-MOD-label [] +xref: DiffAvg: "616.50" +xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4 S 0" +xref: DiffMono: "616.177293" +xref: Formula: "C 40 Fe 1 H 42 N 6 O 6 S 2" +xref: MassAvg: "822.78" +xref: MassMono: "822.195663" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00144 +name: heme-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [ChEBI:17627, DeltaMass:0, PubMed:170910, PubMed:192772, PubMed:2536325, PubMed:9535866, RESID:AA0135, UniMod:390#C] +comment: From DeltaMass: Average Mass: 617. +subset: PSI-MOD-slim +synonym: "(12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate" EXACT RESID-systematic [] +synonym: "4-[1-(S-cysteinyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] +synonym: "BINDING Heme (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "cysteinyl heme" EXACT RESID-alternate [] +synonym: "Heme" RELATED PSI-MS-label [] +synonym: "heme" RELATED UniMod-description [] +synonym: "heme-L-cysteine" EXACT RESID-name [] +synonym: "HemeCys1" EXACT PSI-MOD-label [] +synonym: "S-Heme (on Cysteine)" EXACT DeltaMass-label [] +xref: DiffAvg: "616.50" +xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4 S 0" +xref: DiffMono: "616.177293" +xref: Formula: "C 37 Fe 1 H 37 N 5 O 5 S 1" +xref: MassAvg: "719.64" +xref: MassMono: "719.186478" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00145 +name: tetrakis-L-cysteinyl iron +def: "A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron." [PubMed:1303768, PubMed:2244884, RESID:AA0136] +comment: Cross-link 4. +synonym: "METAL Iron" EXACT UniProt-feature [] +synonym: "tetrakis(cysteinato-kappaS)-iron" EXACT RESID-systematic [] +synonym: "tetrakis-L-cysteinyl iron" EXACT RESID-name [] +xref: DiffAvg: "51.81" +xref: DiffFormula: "C 0 Fe 1 H -4 N 0 O 0 S 0" +xref: DiffMono: "51.904735" +xref: FormalCharge: "2-" +xref: Formula: "C 12 Fe 1 H 16 N 4 O 4 S 4" +xref: MassAvg: "464.37" +xref: MassMono: "463.941474" +xref: Origin: "C, C, C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00738 ! iron containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00146 +name: tetrakis-L-cysteinyl diiron disulfide +def: "A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide." [PubMed:2123937, PubMed:6801028, PubMed:7763242, PubMed:8688437, RESID:AA0137] +comment: Cross-link 4. +synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (2Fe-2S); shared with dimeric partner" EXACT UniProt-feature [] +synonym: "tetrakis-L-cysteinyl diiron disulfide" EXACT RESID-name [] +synonym: "tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron" EXACT RESID-systematic [] +xref: DiffAvg: "171.78" +xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" +xref: DiffMono: "171.783814" +xref: FormalCharge: "2-" +xref: Formula: "C 12 Fe 2 H 16 N 4 O 4 S 6" +xref: MassAvg: "584.34" +xref: MassMono: "583.820553" +xref: Origin: "C, C, C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00147 +name: hexakis-L-cysteinyl triiron trisulfide +def: "A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide." [PubMed:3379067, PubMed:3932661, PubMed:7354058, RESID:AA0138] +comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "hexakis-L-cysteinyl triiron trisulfide" EXACT RESID-name [] +synonym: "tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron" EXACT RESID-systematic [] +synonym: "tri-mu-sulfidotris(biscysteinato-kappaS-iron)" EXACT RESID-alternate [] +xref: DiffAvg: "257.67" +xref: DiffFormula: "C 0 Fe 3 H -6 N 0 O 0 S 3" +xref: DiffMono: "257.675721" +xref: FormalCharge: "3-" +xref: Formula: "C 18 Fe 3 H 24 N 6 O 6 S 9" +xref: MassAvg: "876.50" +xref: MassMono: "875.730830" +xref: Origin: "C, C, C, C, C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00148 +name: tris-L-cysteinyl triiron tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide." [PubMed:10555576, PubMed:2056535, PubMed:3422475, PubMed:6848518, PubMed:7819255, PubMed:9063899, RESID:AA0139] +comment: Cross-link 3. +synonym: "METAL Iron-sulfur (3Fe-4S)" EXACT UniProt-feature [] +synonym: "mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron" EXACT RESID-alternate [] +synonym: "mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron" EXACT RESID-systematic [] +synonym: "tris-L-cysteinyl triiron tetrasulfide" EXACT RESID-name [] +synonym: "tris-L-cysteinyl triiron tetrasulfide C3 cluster" EXACT RESID-alternate [] +synonym: "tris-L-cysteinyl triiron tetrasulfide cubane form" EXACT RESID-alternate [] +synonym: "tris-L-cysteinyl triiron tetrasulfide cuboid cluster" EXACT RESID-alternate [] +synonym: "tris-L-cysteinyl triiron tetrasulfide trigonal cluster" EXACT RESID-alternate [] +xref: DiffAvg: "292.75" +xref: DiffFormula: "C 0 Fe 3 H -3 N 0 O 0 S 4" +xref: DiffMono: "292.671267" +xref: FormalCharge: "3-" +xref: Formula: "C 9 Fe 3 H 12 N 3 O 3 S 7" +xref: MassAvg: "602.17" +xref: MassMono: "601.698821" +xref: Origin: "C, C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00149 +name: tetrakis-L-cysteinyl tetrairon tetrasulfide +def: "A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide." [PubMed:3351918, PubMed:7803404, PubMed:7819196, PubMed:932007, RESID:AA0140] +comment: Cross-link 4. +synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (4Fe-4S); shared with dimeric partner" EXACT UniProt-feature [] +synonym: "tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon" EXACT RESID-systematic [] +synonym: "tetra-mu3-sulfidotetrakis(S-cysteinyliron)" EXACT RESID-alternate [] +synonym: "tetrakis-L-cysteinyl tetrairon tetrasulfide" EXACT RESID-name [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.597831" +xref: FormalCharge: "2-" +xref: Formula: "C 12 Fe 4 H 16 N 4 O 4 S 8" +xref: MassAvg: "760.15" +xref: MassMono: "759.634570" +xref: Origin: "C, C, C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00150 +name: L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide +def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide." [PubMed:10525412, PubMed:12215645, PubMed:12733878, PubMed:1529354, PubMed:8027059, RESID:AA0141] +comment: Cross-link 2; incidental to RESID:AA0300. +synonym: "cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon" EXACT RESID-systematic [] +synonym: "L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide" EXACT RESID-name [] +synonym: "nitrogenase iron-molybdenum cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "991.53" +xref: DiffFormula: "C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9" +xref: DiffMono: "993.213036" +xref: Formula: "C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10" +xref: MassAvg: "1231.81" +xref: MassMono: "1233.281133" +xref: Origin: "C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00743 ! molybdenum containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00151 +name: L-cysteinyl molybdopterin +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin." [PubMed:14527393, PubMed:7878465, PubMed:9428520, RESID:AA0142, UniMod:391#C] +subset: PSI-MOD-slim +synonym: "(4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene" EXACT RESID-systematic [] +synonym: "cysteinyl Mo-molybdopterin" EXACT RESID-alternate [] +synonym: "cysteinyl Mo-pterin" EXACT RESID-alternate [] +synonym: "L-cysteinyl molybdopterin" EXACT RESID-name [] +synonym: "METAL Molybdenum-pterin" EXACT UniProt-feature [] +synonym: "molybdoenzyme molybdenum cofactor" EXACT RESID-alternate [] +synonym: "Molybdopterin" RELATED PSI-MS-label [] +synonym: "molybdopterin" RELATED UniMod-description [] +synonym: "MoPterCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "520.27" +xref: DiffFormula: "C 10 H 11 Mo 1 N 5 O 8 P 1 S 2" +xref: DiffMono: "521.884074" +xref: Formula: "C 13 H 16 Mo 1 N 6 O 9 P 1 S 3" +xref: MassAvg: "623.41" +xref: MassMono: "624.893259" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00744 ! molybdenum pterin containing modification +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00152 +name: S-(8alpha-FAD)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine." [PubMed:10220347, RESID:AA0143, UniMod:50#C] +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "8alpha-(S-cysteinyl)FAD" EXACT RESID-alternate [] +synonym: "FAD" RELATED PSI-MS-label [] +synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] +synonym: "MOD_RES S-8alpha-FAD cysteine" EXACT UniProt-feature [] +synonym: "S-(8alpha-FAD)-L-cysteine" EXACT RESID-name [] +synonym: "S8aFADCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0" +xref: DiffMono: "783.141485" +xref: Formula: "C 30 H 36 N 10 O 16 P 2 S 1" +xref: MassAvg: "886.68" +xref: MassMono: "886.150669" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00153 +name: 3'-(8alpha-FAD)-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine." [PubMed:241294, PubMed:8076, RESID:AA0144, UniMod:50#H] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "3'-(8alpha-FAD)-L-histidine" EXACT RESID-name [] +synonym: "8alpha-(N(delta)-histidyl)FAD" EXACT RESID-alternate [] +synonym: "8alpha-(N3'-histidyl)FAD" EXACT RESID-alternate [] +synonym: "8alpha-N1-histidyl FAD" RELATED RESID-misnomer [] +synonym: "FAD" RELATED PSI-MS-label [] +synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] +synonym: "MOD_RES Pros-8alpha-FAD histidine" EXACT UniProt-feature [] +synonym: "N(pi)-(8alpha-FAD)-histidine" EXACT RESID-alternate [] +synonym: "Np8aFADHis" EXACT PSI-MOD-label [] +synonym: "pros-(8alpha-FAD)-histidine" EXACT RESID-alternate [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" +xref: DiffMono: "783.141485" +xref: Formula: "C 33 H 38 N 12 O 16 P 2" +xref: MassAvg: "920.68" +xref: MassMono: "920.200396" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00154 +name: O4'-(8alpha-FAD)-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine." [DeltaMass:0, PubMed:7391034, RESID:AA0145, UniMod:50#Y] +comment: From DeltaMass: Average Mass: 783 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "8alpha-(O4'-tyrosyl)FAD" EXACT RESID-alternate [] +synonym: "FAD" RELATED PSI-MS-label [] +synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] +synonym: "MOD_RES O-8alpha-FAD tyrosine" EXACT UniProt-feature [] +synonym: "O-8 alpha-Flavin [FAD])- (of Tyrosine)" EXACT DeltaMass-label [] +synonym: "O4'-(8alpha-FAD)-L-tyrosine" EXACT RESID-name [] +synonym: "O8aFADTyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" +xref: DiffMono: "783.141485" +xref: Formula: "C 36 H 40 N 10 O 17 P 2" +xref: MassAvg: "946.72" +xref: MassMono: "946.204813" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00155 +name: 3'-hydroxylation of L-tyrosine to L-3',4'-dihydroxyphenylalanine +def: "A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine." [DeltaMass:0, OMSSA:194, OMSSA:64, PubMed:1610822, PubMed:1903612, PubMed:3734192, RESID:AA0146, UniMod:35#Y] +comment: incidental to RESID:AA0368 From DeltaMass: Average Mass: 16 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA)" EXACT DeltaMass-label [] +synonym: "3HyTyr" EXACT PSI-MOD-label [] +synonym: "hydroxylationy" EXACT OMSSA-label [] +synonym: "L-3',4'-dihydroxyphenylalanine" EXACT RESID-name [] +synonym: "L-3'-hydroxytyrosine" EXACT RESID-alternate [] +synonym: "L-DOPA" EXACT RESID-alternate [] +synonym: "levodopa" EXACT RESID-alternate [] +synonym: "mod194" EXACT OMSSA-label [] +synonym: "MOD_RES 3',4'-dihydroxyphenylalanine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 9 H 9 N 1 O 3" +xref: MassAvg: "179.18" +xref: MassMono: "179.058243" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00707 ! hydroxylated tyrosine + +[Term] +id: MOD:00156 +name: oxidation of tyrosine to L-2',4',5'-topaquinone +def: "A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone." [ChEBI:21187, PubMed:10387067, PubMed:1457410, PubMed:1569055, PubMed:2111581, RESID:AA0147, UniMod:392#Y] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "2,4,5-trihydroxyphenylalanine quinone" EXACT RESID-alternate [] +synonym: "5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone" EXACT RESID-alternate [] +synonym: "L-2',4',5'-topaquinone" EXACT RESID-name [] +synonym: "L-2,4,5-TOPAquinone" EXACT RESID-alternate [] +synonym: "MOD_RES 2',4',5'-topaquinone" EXACT UniProt-feature [] +synonym: "Quinone" RELATED PSI-MS-label [] +synonym: "quinone" RELATED UniMod-description [] +synonym: "TopaQ" EXACT PSI-MOD-label [] +synonym: "TPQ" EXACT RESID-alternate [] +xref: DiffAvg: "29.98" +xref: DiffFormula: "C 0 H -2 N 0 O 2" +xref: DiffMono: "29.974179" +xref: Formula: "C 9 H 7 N 1 O 4" +xref: MassAvg: "193.16" +xref: MassMono: "193.037508" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00157 +name: oxidation of tryptophan to L-tryptophyl quinone +def: "A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone." [DeltaMass:0, PubMed:2028257, RESID:AA0148, UniMod:392#W] +comment: incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid" EXACT RESID-alternate [] +synonym: "3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione" EXACT RESID-alternate [] +synonym: "6,7 Dione (from Tryptophan)" EXACT DeltaMass-label [] +synonym: "L-tryptophyl quinone" EXACT RESID-name [] +synonym: "MOD_RES Tryptophylquinone" EXACT UniProt-feature [] +synonym: "N-(3-carboxy-1-oxopropyl)-L-tryptophan" EXACT RESID-alternate [] +synonym: "Quinone" RELATED PSI-MS-label [] +synonym: "quinone" RELATED UniMod-description [] +synonym: "TrpQ" EXACT PSI-MOD-label [] +xref: DiffAvg: "29.98" +xref: DiffFormula: "C 0 H -2 N 0 O 2" +xref: DiffMono: "29.974179" +xref: Formula: "C 11 H 8 N 2 O 3" +xref: MassAvg: "216.20" +xref: MassMono: "216.053492" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00158 +name: 4'-(L-tryptophan)-L-tryptophyl quinone +def: "A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone." [ChEBI:20251, DeltaMass:0, PubMed:2028257, RESID:AA0149] +comment: Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28. +subset: PSI-MOD-slim +synonym: "2,4-BisTrp-6,7-dione (from Tryptophan)" EXACT DeltaMass-label [] +synonym: "2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate [] +synonym: "3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione" EXACT RESID-systematic [] +synonym: "4'-tryptophan-tryptophylquinone" EXACT RESID-alternate [] +synonym: "4-(2'-tryptophyl)tryptophan-6,7-dione" EXACT RESID-alternate [] +synonym: "4-(L-tryptophan-2-yl)-L-tryptophyl quinone" EXACT RESID-name [] +synonym: "alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Tryptophan tryptophylquinone (Trp-Trp)" EXACT UniProt-feature [] +synonym: "TTQ" EXACT RESID-alternate [] +synonym: "XLNK-4'Trp-TrpQ" EXACT PSI-MOD-label [] +xref: DiffAvg: "27.97" +xref: DiffFormula: "C 0 H -4 N 0 O 2" +xref: DiffMono: "27.958529" +xref: Formula: "C 22 H 16 N 4 O 4" +xref: MassAvg: "400.39" +xref: MassMono: "400.117155" +xref: Origin: "W, W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00159 +name: O-phosphopantetheine-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine." [DeltaMass:0, PubMed:10320345, PubMed:10997907, PubMed:12057197, PubMed:12869567, PubMed:4568609, RESID:AA0150, UniMod:49#S] +comment: UniMod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339 +subset: PSI-MOD-slim +synonym: "(2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide" EXACT RESID-systematic [] +synonym: "4'-Phosphopantetheine" EXACT DeltaMass-label [] +synonym: "MOD_RES O-(pantetheine 4'-phosphoryl)serine" EXACT UniProt-feature [] +synonym: "O-phosphopantetheine-L-serine" EXACT RESID-name [] +synonym: "OPpantSer" EXACT PSI-MOD-label [] +synonym: "Phosphopantetheine" RELATED PSI-MS-label [] +synonym: "Phosphopantetheine" RELATED UniMod-description [] +xref: DiffAvg: "340.33" +xref: DiffFormula: "C 11 H 21 N 2 O 6 P 1 S 1" +xref: DiffMono: "340.085794" +xref: Formula: "C 14 H 26 N 3 O 8 P 1 S 1" +xref: MassAvg: "427.41" +xref: MassMono: "427.117822" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00160 +name: N4-glycosyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine." [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var] +subset: PSI-MOD-slim +synonym: "N4GlycoAsn" EXACT PSI-MOD-label [] +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00006 ! N-glycosylated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00161 +name: S-glucosyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine." [PubMed:1145128, PubMed:15279557, PubMed:5286858, RESID:AA0152, UniMod:41#C] +synonym: "(2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD S-linked (Glc)" EXACT UniProt-feature [] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +synonym: "S-(beta-D-glucopyranosyl)cysteine" EXACT RESID-alternate [] +synonym: "S-glucosyl-L-cysteine" EXACT RESID-name [] +synonym: "S-glycosyl-cysteine" EXACT RESID-alternate [] +synonym: "SGlcCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5 S 0" +xref: DiffMono: "162.052823" +xref: Formula: "C 9 H 15 N 1 O 6 S 1" +xref: MassAvg: "265.28" +xref: MassMono: "265.062008" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00426 ! S-glycosylated residue +is_a: MOD:00433 ! glucosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00162 +name: O5-glucosylgalactosyl-L-hydroxylysine +def: "A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine." [PubMed:15149698, PubMed:4288358, PubMed:4319110, RESID:AA0153, UniMod:393] +comment: Secondary to RESID:AA0028. +subset: PSI-MOD-slim +synonym: "(2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid" EXACT RESID-systematic [] +synonym: "5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine" EXACT RESID-alternate [] +synonym: "Glucosylgalactosyl" RELATED PSI-MS-label [] +synonym: "glucosylgalactosyl hydroxylysine" RELATED UniMod-description [] +synonym: "O5-glucosylgalactosyl-L-hydroxylysine" EXACT RESID-name [] +synonym: "OGlcGal5HyLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "340.28" +xref: DiffFormula: "C 12 H 20 N 0 O 11" +xref: DiffMono: "340.100561" +xref: Formula: "C 18 H 32 N 2 O 12" +xref: MassAvg: "468.46" +xref: MassMono: "468.195524" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00037 ! 5-hydroxy-L-lysine +is_a: MOD:00396 ! O-glycosylated residue +is_a: MOD:00476 ! galactosylated residue +is_a: MOD:00726 ! glucosylated + +[Term] +id: MOD:00163 +name: O-(N-acetylamino)galactosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine." [PubMed:115869, PubMed:16005634, PubMed:3086323, PubMed:8948436, PubMed:9092502, RESID:AA0154] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (GalNAc)" EXACT UniProt-feature [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "mucin type O-glycosylserine" EXACT RESID-alternate [] +synonym: "O-(N-acetylamino)galactosyl-L-serine" EXACT RESID-name [] +synonym: "O3-(N-acetylgalactosaminyl)serine" EXACT RESID-alternate [] +synonym: "OGalNAcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 11 H 18 N 2 O 7" +xref: MassAvg: "290.27" +xref: MassMono: "290.111401" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00563 ! N-acetylaminogalactosylated residue +is_a: MOD:01675 ! O-(N-acetylamino)hexosyl-L-serine + +[Term] +id: MOD:00164 +name: O-(N-acetylamino)galactosyl-L-threonine +def: "A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine." [PubMed:16005634, PubMed:1997327, PubMed:3086323, PubMed:8948436, PubMed:9092502, RESID:AA0155] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (GalNAc)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "mucin type O-glycosylthreonine" EXACT RESID-alternate [] +synonym: "O-(N-acetylamino)galactosyl-L-threonine" EXACT RESID-name [] +synonym: "O3-(N-acetylgalactosaminyl)threonine" EXACT RESID-alternate [] +synonym: "OGalNAcThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 12 H 20 N 2 O 7" +xref: MassAvg: "304.30" +xref: MassMono: "304.127051" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00563 ! N-acetylaminogalactosylated residue +is_a: MOD:01676 ! O-(N-acetylamino)hexosyl-L-threonine + +[Term] +id: MOD:00165 +name: 1'-mannosyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan." [PubMed:1482345, PubMed:16150691, RESID:AA0156] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1'-glycosyl-L-tryptophan" EXACT RESID-alternate [] +synonym: "1'-mannosyl-L-tryptophan" EXACT RESID-name [] +synonym: "CARBOHYD N-linked (Man)" EXACT UniProt-feature [] +synonym: "N-mannosyl-tryptophan" EXACT RESID-alternate [] +synonym: "N1'ManTrp" EXACT PSI-MOD-label [] +synonym: "N1-mannosyl-tryptophan" EXACT RESID-alternate [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 17 H 20 N 2 O 6" +xref: MassAvg: "348.36" +xref: MassMono: "348.132136" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00006 ! N-glycosylated residue +is_a: MOD:00595 ! mannosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00166 +name: O4'-glucosyl-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine." [PubMed:15279557, PubMed:3181138, RESID:AA0157, UniMod:41#Y] +synonym: "(2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +synonym: "O4'-glucosyl-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-glycosyl-L-tyrosine" EXACT RESID-alternate [] +synonym: "O4GlcTyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 15 H 19 N 1 O 7" +xref: MassAvg: "325.32" +xref: MassMono: "325.116152" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00433 ! glucosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:01927 ! O-glycosyl-L-tyrosine + +[Term] +id: MOD:00167 +name: N-asparaginyl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine." [PubMed:1824714, PubMed:8276756, RESID:AA0158] +synonym: "GPIAsn" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated asparagine" EXACT UniProt-feature [] +synonym: "N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 6 H 13 N 3 O 6 P 1" +xref: MassAvg: "254.16" +xref: MassMono: "254.054197" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00168 +name: N-aspartyl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine." [PubMed:7120400, RESID:AA0159] +synonym: "GPIAsp" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated aspartate" EXACT UniProt-feature [] +synonym: "N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 6 H 12 N 2 O 7 P 1" +xref: MassAvg: "255.14" +xref: MassMono: "255.038212" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:00169 +name: N-cysteinyl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine." [PubMed:2897081, RESID:AA0160] +synonym: "GPICys" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated cysteine" EXACT UniProt-feature [] +synonym: "N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1 S 0" +xref: DiffMono: "123.008530" +xref: Formula: "C 5 H 12 N 2 O 5 P 1 S 1" +xref: MassAvg: "243.19" +xref: MassMono: "243.020454" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00170 +name: N-glycyl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine." [PubMed:2341397, RESID:AA0161] +synonym: "GPIGly" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated glycine" EXACT UniProt-feature [] +synonym: "N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 4 H 10 N 2 O 5 P 1" +xref: MassAvg: "197.11" +xref: MassMono: "197.032733" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:00171 +name: N-seryl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine." [PubMed:2111324, PubMed:8448158, RESID:AA0162] +synonym: "GPISer" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated serine" EXACT UniProt-feature [] +synonym: "N-seryl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 5 H 12 N 2 O 6 P 1" +xref: MassAvg: "227.13" +xref: MassMono: "227.043298" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00172 +name: N-alanyl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine." [PubMed:7682556, PubMed:7744038, RESID:AA0163] +synonym: "GPIAla" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated alanine" EXACT UniProt-feature [] +synonym: "N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 5 H 12 N 2 O 5 P 1" +xref: MassAvg: "211.13" +xref: MassMono: "211.048383" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00901 ! modified L-alanine residue + +[Term] +id: MOD:00173 +name: N-threonyl-glycosylphosphatidylinositolethanolamine +def: "A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine." [RESID:AA0164] +synonym: "GPIThr" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-anchor amidated threonine" EXACT UniProt-feature [] +synonym: "N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 6 H 14 N 2 O 6 P 1" +xref: MassAvg: "241.16" +xref: MassMono: "241.058948" +xref: Origin: "T" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00818 ! glycosylphosphatidylinositolated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00174 +name: N-glycyl-glycosylsphingolipidinositolethanolamine +def: "A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, PubMed:8404891, RESID:AA0165] +synonym: "GSIGly" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-like-anchor amidated glycine" EXACT UniProt-feature [] +synonym: "N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 4 H 10 N 2 O 5 P 1" +xref: MassAvg: "197.11" +xref: MassMono: "197.032733" +xref: Origin: "G" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00466 ! glycosylsphingolipidinositolated residue +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:00175 +name: N-seryl-glycosylsphingolipidinositolethanolamine +def: "A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, PubMed:2721485, PubMed:8269952, RESID:AA0166] +synonym: "GSISer" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-like-anchor amidated serine" EXACT UniProt-feature [] +synonym: "N-seryl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 5 H 12 N 2 O 6 P 1" +xref: MassAvg: "227.13" +xref: MassMono: "227.043298" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00466 ! glycosylsphingolipidinositolated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00176 +name: O-(phosphoribosyl dephospho-coenzyme A)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [PubMed:10924139, PubMed:11052675, PubMed:179809, PubMed:180526, PubMed:368065, RESID:AA0167, UniMod:395#S] +comment: pRibodePcoA +subset: PSI-MOD-slim +synonym: "MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine" EXACT UniProt-feature [] +synonym: "O-(phosphoribosyl dephospho-coenzyme A)-L-serine" EXACT RESID-name [] +synonym: "O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine" EXACT RESID-alternate [] +synonym: "O3-(phosphoribosyl dephospho-coenzyme A)-L-serine" EXACT RESID-alternate [] +synonym: "O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine" EXACT RESID-alternate [] +synonym: "OPRibdPCoASer" EXACT PSI-MOD-label [] +synonym: "phosphoribosyl dephospho-coenzyme A" RELATED UniMod-description [] +synonym: "PhosphoribosyldephosphoCoA" RELATED PSI-MS-label [] +xref: DiffAvg: "881.63" +xref: DiffFormula: "C 26 H 42 N 7 O 19 P 3 S 1" +xref: DiffMono: "881.146903" +xref: Formula: "C 29 H 47 N 8 O 21 P 3 S 1" +xref: MassAvg: "968.71" +xref: MassMono: "968.178931" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00177 +name: omega-N-(ADP-ribosyl)-L-arginine +def: "A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine." [DeltaMass:0, PubMed:15842200, PubMed:209022, PubMed:3090031, PubMed:3923473, PubMed:6582062, RESID:AA0168, UniMod:213#R] +comment: From DeltaMass: Average Mass: 541. +subset: PSI-MOD-slim +synonym: "(S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] +synonym: "ADP Ribose addition" RELATED UniMod-description [] +synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] +synonym: "ADPRibArg" EXACT PSI-MOD-label [] +synonym: "MOD_RES ADP-ribosylarginine" EXACT UniProt-feature [] +synonym: "N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine" EXACT RESID-alternate [] +synonym: "N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +synonym: "N-(ADP-ribosyl)- (on Arginine)" EXACT DeltaMass-label [] +synonym: "omega-N-(ADP-ribosyl)-L-arginine" EXACT RESID-name [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 21 H 33 N 9 O 14 P 2" +xref: MassAvg: "697.49" +xref: MassMono: "697.162220" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00178 +name: S-(ADP-ribosyl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine." [DeltaMass:0, PubMed:15842200, PubMed:3863818, RESID:AA0169, UniMod:213#C] +comment: From DeltaMass: Average Mass: 541. +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "ADP Ribose addition" RELATED UniMod-description [] +synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] +synonym: "ADPRibCys" EXACT PSI-MOD-label [] +synonym: "MOD_RES ADP-ribosylcysteine" EXACT UniProt-feature [] +synonym: "S-(ADP-ribosyl)- (on Cysteine)" EXACT DeltaMass-label [] +synonym: "S-(ADP-ribosyl)-L-cysteine" EXACT RESID-name [] +synonym: "S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +synonym: "S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2 S 0" +xref: DiffMono: "541.061109" +xref: Formula: "C 18 H 26 N 6 O 14 P 2 S 1" +xref: MassAvg: "644.44" +xref: MassMono: "644.070294" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00179 +name: L-glutamyl 5-glycerylphosphorylethanolamine +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine." [PubMed:2511205, PubMed:2569467, PubMed:9662537, RESID:AA0170, UniMod:396#E] +comment: glycerylPE +subset: PSI-MOD-slim +synonym: "(S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "5-L-glutamyl glycerylphosphorylethanolamine" EXACT RESID-name [] +synonym: "5GlyceroPEtAGlu" EXACT PSI-MOD-label [] +synonym: "GlycerylPE" RELATED PSI-MS-label [] +synonym: "glycerylphosphorylethanolamine" RELATED UniMod-description [] +synonym: "L-glutamyl 5-glycerophosphoethanolamine" EXACT RESID-alternate [] +synonym: "L-glutamyl 5-glycerophosphorylethanolamine" EXACT RESID-alternate [] +synonym: "L-glutamyl 5-glycerylphosphorylethanolamine" EXACT RESID-alternate [] +synonym: "MOD_RES 5-glutamyl glycerylphosphorylethanolamine" EXACT UniProt-feature [] +xref: DiffAvg: "197.13" +xref: DiffFormula: "C 5 H 12 N 1 O 5 P 1" +xref: DiffMono: "197.045309" +xref: Formula: "C 10 H 19 N 2 O 8 P 1" +xref: MassAvg: "326.24" +xref: MassMono: "326.087902" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00180 +name: S-sulfo-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine." [PubMed:12876326, PubMed:14752058, PubMed:643076, RESID:AA0171, UniMod:40#C] +synonym: "(2R)-2-amino-3-(sulfosulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(sulfothio)propanoic acid" EXACT RESID-alternate [] +synonym: "3-(sulfosulfanyl)-L-alanine" EXACT RESID-alternate [] +synonym: "cysteine sulfate thioester" EXACT RESID-alternate [] +synonym: "cysteine-S-sulfonic acid" EXACT RESID-alternate [] +synonym: "O-Sulfonation" RELATED UniMod-description [] +synonym: "S-sulfo-L-cysteine" EXACT RESID-name [] +synonym: "S-sulfocysteine" EXACT PSI-MOD-alternate [] +synonym: "S-sulfocysteine" EXACT RESID-alternate [] +synonym: "SSulfCys" EXACT PSI-MOD-label [] +synonym: "Sulfo" RELATED PSI-MS-label [] +xref: DiffAvg: "80.06" +xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" +xref: DiffMono: "79.956815" +xref: Formula: "C 3 H 5 N 1 O 4 S 2" +xref: MassAvg: "183.20" +xref: MassMono: "182.966000" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00695 ! sulfated residue +is_a: MOD:00777 ! residues isobaric at 182.96-182.98 Da +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00181 +name: O4'-sulfo-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine." [DeltaMass:88, OMSSA:114, PubMed:10226369, PubMed:14752058, PubMed:2303439, PubMed:3778455, PubMed:3801003, RESID:AA0172, UniMod:40#Y] +comment: From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161. +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate" EXACT RESID-alternate [] +synonym: "MOD_RES Sulfotyrosine" EXACT UniProt-feature [] +synonym: "O-Sulfonation" RELATED UniMod-description [] +synonym: "O4'-sulfo-L-tyrosine" EXACT RESID-name [] +synonym: "O4-sulfotyrosine" EXACT RESID-alternate [] +synonym: "OSulfTyr" EXACT PSI-MOD-label [] +synonym: "sulfationy" EXACT OMSSA-label [] +synonym: "Sulfo" RELATED PSI-MS-label [] +synonym: "Sulphation (of O of Tyrosine)" EXACT DeltaMass-label [] +synonym: "tyrosine sulfate" EXACT RESID-alternate [] +synonym: "tyrosine-O-sulfonic acid" EXACT RESID-alternate [] +synonym: "tyrosine-O-sulphonic acid" EXACT RESID-alternate [] +synonym: "Tyrosinyl Sulphate" EXACT DeltaMass-label [] +xref: DiffAvg: "80.06" +xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" +xref: DiffMono: "79.956815" +xref: Formula: "C 9 H 9 N 1 O 5 S 1" +xref: MassAvg: "243.23" +xref: MassMono: "243.020143" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00695 ! sulfated residue +is_a: MOD:00774 ! residues isobaric at 243.02-243.03 Da +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00182 +name: L-bromohistidine +def: "A protein modification that effectively converts an L-histidine residue to L-bromohistidine." [PubMed:2076468, PubMed:9033387, RESID:AA0173, UniMod:340#H] +synonym: "Br1His" EXACT PSI-MOD-label [] +synonym: "bromination" RELATED UniMod-description [] +synonym: "Bromo" RELATED PSI-MS-label [] +synonym: "L-bromohistidine" EXACT RESID-name [] +synonym: "MOD_RES Bromohistidine" EXACT UniProt-feature [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 6 H 6 N 3 O 1" +xref: MassAvg: "216.04" +xref: MassMono: "214.969424" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01049 ! halogenated histidine +is_a: MOD:01912 ! monobrominated residue + +[Term] +id: MOD:00183 +name: L-2'-bromophenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine." [DeltaMass:83, PubMed:2059627, PubMed:2076468, PubMed:9033387, RESID:AA0174] +comment: From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa. +synonym: "(S)-2-amino-3-(2-bromophenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2'BrPhe" EXACT PSI-MOD-label [] +synonym: "bromination" RELATED UniMod-description [] +synonym: "Bromo" RELATED PSI-MS-label [] +synonym: "L-2'-bromophenylalanine" EXACT RESID-name [] +synonym: "L-o-bromination of Phe with 79Br" EXACT DeltaMass-label [] +synonym: "o-bromophenylalanine" EXACT RESID-alternate [] +synonym: "ortho-bromophenylalanine" EXACT RESID-alternate [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 9 H 8 N 1 O 1" +xref: MassAvg: "226.07" +xref: MassMono: "224.978926" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00972 ! monobrominated L-phenylalanine + +[Term] +id: MOD:00184 +name: L-3'-bromophenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine." [PubMed:2076468, PubMed:9033387, RESID:AA0175] +synonym: "(S)-2-amino-3-(3-bromophenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3'BrPhe" EXACT PSI-MOD-label [] +synonym: "bromination" RELATED UniMod-description [] +synonym: "Bromo" RELATED PSI-MS-label [] +synonym: "L-3'-bromophenylalanine" EXACT RESID-name [] +synonym: "m-bromophenylalanine" EXACT RESID-alternate [] +synonym: "meta-bromophenylalanine" EXACT RESID-alternate [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 9 H 8 N 1 O 1" +xref: MassAvg: "226.07" +xref: MassMono: "224.978926" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00972 ! monobrominated L-phenylalanine + +[Term] +id: MOD:00185 +name: L-4'-bromophenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine." [PubMed:2076468, PubMed:9033387, RESID:AA0176] +synonym: "(2S)-2-amino-3-(4-bromophenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "4'BrPhe" EXACT PSI-MOD-label [] +synonym: "bromination" RELATED UniMod-description [] +synonym: "Bromo" RELATED PSI-MS-label [] +synonym: "L-4'-bromophenylalanine" EXACT RESID-name [] +synonym: "p-bromophenylalanine" EXACT RESID-alternate [] +synonym: "para-bromophenylalanine" EXACT RESID-alternate [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 9 H 8 N 1 O 1" +xref: MassAvg: "226.07" +xref: MassMono: "224.978926" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00972 ! monobrominated L-phenylalanine + +[Term] +id: MOD:00186 +name: 3',3'',5'-triiodo-L-thyronine +def: "A protein modification that effectively substitutes an L-tyrosine residue with 3',3'',5'-triiodo-L-thyronine." [ChEBI:18258, DeltaMass:0, RESID:AA0177, UniMod:397] +comment: From DeltaMass: Average Mass: 470. +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "3',3'',5'-triiodo-L-thyronine" EXACT RESID-name [] +synonym: "3,3',5-triiodo-L-thyronine" EXACT RESID-alternate [] +synonym: "3,5,3'-triiodo-L-thyronine" EXACT RESID-alternate [] +synonym: "3,5,3'-Triiodothyronine (from Tyrosine)" EXACT DeltaMass-label [] +synonym: "4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine" EXACT RESID-alternate [] +synonym: "I3Thy" EXACT PSI-MOD-label [] +synonym: "liothyronine" EXACT RESID-alternate [] +synonym: "MOD_RES Triiodothyronine" EXACT UniProt-feature [] +synonym: "O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine" EXACT RESID-alternate [] +synonym: "T3" EXACT RESID-alternate [] +synonym: "triiodo" RELATED UniMod-description [] +synonym: "Triiodothyronine" RELATED PSI-MS-label [] +xref: DiffAvg: "469.79" +xref: DiffFormula: "C 6 H 1 I 3 N 0 O 1" +xref: DiffMono: "469.716158" +xref: Formula: "C 15 H 10 I 3 N 1 O 3" +xref: MassAvg: "632.96" +xref: MassMono: "632.779486" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00502 ! triiodinated residue +is_a: MOD:00998 ! iodinated tyrosine + +[Term] +id: MOD:00187 +name: L-thyroxine +def: "A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine." [ChEBI:18332, PubMed:6704086, RESID:AA0178, UniMod:398] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "3',3'',5',5''-tetraiodo-L-thyronine" EXACT RESID-alternate [] +synonym: "3,3',5,5'-tetraiodo-L-thyronine" EXACT RESID-alternate [] +synonym: "3,5,3',5'-tetraiodo-L-thyronine" EXACT RESID-alternate [] +synonym: "4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine" EXACT RESID-alternate [] +synonym: "I4Thy" EXACT PSI-MOD-label [] +synonym: "L-thyroxine" EXACT RESID-name [] +synonym: "MOD_RES Thyroxine" EXACT UniProt-feature [] +synonym: "O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine" EXACT RESID-alternate [] +synonym: "T4" EXACT RESID-alternate [] +synonym: "tetraiodo" RELATED UniMod-description [] +synonym: "Thyroxine" RELATED PSI-MS-label [] +xref: DiffAvg: "595.68" +xref: DiffFormula: "C 6 H 0 I 4 N 0 O 1" +xref: DiffMono: "595.612805" +xref: Formula: "C 15 H 9 I 4 N 1 O 3" +xref: MassAvg: "758.86" +xref: MassMono: "758.676134" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00998 ! iodinated tyrosine + +[Term] +id: MOD:00188 +name: 6'-bromo-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan." [PubMed:12118011, PubMed:9030520, PubMed:9033387, PubMed:9434739, RESID:AA0179, UniMod:340#W] +synonym: "(2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "6'-bromo-L-tryptophan" EXACT RESID-name [] +synonym: "6'-BrTrp" EXACT PSI-MOD-label [] +synonym: "bromination" RELATED UniMod-description [] +synonym: "Bromo" RELATED PSI-MS-label [] +synonym: "MOD_RES 6'-bromotryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 11 H 9 N 2 O 1" +xref: MassAvg: "265.11" +xref: MassMono: "263.989825" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01068 ! halogenated tryptophan +is_a: MOD:01912 ! monobrominated residue + +[Term] +id: MOD:00189 +name: dehydroalanine (Ser) +def: "A protein modification that effectively converts an L-serine residue to dehydroalanine." [DeltaMass:0, OMSSA:140, OMSSA:164, OMSSA:96, PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181#SER, UniMod:23#S] +subset: PSI-MOD-slim +synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] +synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] +synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "anhydroserine" EXACT RESID-alternate [] +synonym: "beta-elim-s" EXACT OMSSA-label [] +synonym: "Dehydrated" RELATED PSI-MS-label [] +synonym: "dehydro" EXACT OMSSA-label [] +synonym: "dehydroalanine" EXACT RESID-name [] +synonym: "Dha" EXACT RESID-alternate [] +synonym: "Dha(Ser)" EXACT PSI-MOD-label [] +synonym: "MOD_RES 2,3-didehydroalanine (Ser)" EXACT UniProt-feature [] +synonym: "phospholosss" EXACT OMSSA-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 3 H 3 N 1 O 1" +xref: MassAvg: "69.06" +xref: MassMono: "69.021464" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00416 ! phosphorylation of an hydroxyl amino acid with prompt loss of phosphate +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01168 ! dehydroalanine + +[Term] +id: MOD:00190 +name: dehydrobutyrine (Thr) +def: "A protein modification that effectively converts an L-threonine residue to dehydrobutyrine." [DeltaMass:0, OMSSA:141, OMSSA:164, OMSSA:97, PubMed:1547888, PubMed:3769923, RESID:AA0182, UniMod:23#T] +subset: PSI-MOD-slim +synonym: "(2Z)-2-aminobut-2-enoic acid" EXACT RESID-systematic [] +synonym: "(Z)-2-amino-2-butenoic acid" EXACT RESID-alternate [] +synonym: "(Z)-2-aminobutenoic acid" EXACT RESID-alternate [] +synonym: "(Z)-dehydrobutyrine" EXACT RESID-name [] +synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate [] +synonym: "3-methyldehydroalanine" EXACT RESID-alternate [] +synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate [] +synonym: "anhydrothreonine" EXACT RESID-alternate [] +synonym: "beta-elim-t" EXACT OMSSA-label [] +synonym: "Dehydrated" RELATED PSI-MS-label [] +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +synonym: "dehydro" EXACT OMSSA-label [] +synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] +synonym: "Dhb" EXACT RESID-alternate [] +synonym: "Dhb(Thr)" EXACT PSI-MOD-label [] +synonym: "methyl-dehydroalanine" EXACT RESID-alternate [] +synonym: "MOD_RES (Z)-2,3-didehydrobutyrine" EXACT UniProt-feature [] +synonym: "phospholosst" EXACT OMSSA-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00416 ! phosphorylation of an hydroxyl amino acid with prompt loss of phosphate +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01703 ! dehydrobutyrine + +[Term] +id: MOD:00191 +name: (Z)-2,3-didehydrotyrosine +def: "A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine." [PubMed:1347277, PubMed:9631087, RESID:AA0183] +comment: incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 +subset: PSI-MOD-slim +synonym: "(2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid" EXACT RESID-systematic [] +synonym: "(Z)-2,3-didehydrogenated tyrosine" EXACT PSI-MOD-alternate [] +synonym: "(Z)-2,3-didehydrotyrosine" EXACT RESID-name [] +synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] +synonym: "amino-(para-hydroxybenzylidenyl)acetic acid" EXACT RESID-alternate [] +synonym: "cis-dehydrotyrosine" EXACT RESID-alternate [] +synonym: "Didehydro" RELATED PSI-MS-label [] +synonym: "green fluorescent protein chromophore" EXACT RESID-alternate [] +synonym: "MOD_RES (Z)-2,3-didehydrotyrosine" EXACT UniProt-feature [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "red fluorescent protein chromophore" EXACT RESID-alternate [] +synonym: "Z-dHTyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 9 H 7 N 1 O 2" +xref: MassAvg: "161.16" +xref: MassMono: "161.047678" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00706 ! dehydrogenated tyrosine + +[Term] +id: MOD:00192 +name: L-serine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine." [ChEBI:21393, PubMed:1347277, PubMed:9631087, RESID:AA0184] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "(2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-imidazolinone (Ser-Gly)" EXACT UniProt-feature [] +synonym: "green fluorescent protein chromophore" EXACT RESID-alternate [] +synonym: "L-serine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "seryl-5-imidazolinone glycine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 6 N 2 O 2" +xref: MassAvg: "126.11" +xref: MassMono: "126.042927" +xref: Origin: "G, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00193 +name: L-3-oxoalanine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to L-oxoalanine." [DeltaMass:350, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9478923, RESID:AA0185#CYS, UniMod:402#C] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate [] +synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer [] +synonym: "L-3-oxoalanine" EXACT RESID-name [] +synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate [] +synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate [] +synonym: "L-serinesemialdehyde" RELATED RESID-misnomer [] +synonym: "MOD_RES 3-oxoalanine (Cys)" EXACT UniProt-feature [] +synonym: "Oxala(Cys)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.08" +xref: DiffFormula: "C 0 H -2 N 0 O 1 S -1" +xref: DiffMono: "-17.992806" +xref: Formula: "C 3 H 3 N 1 O 2" +xref: MassAvg: "85.06" +xref: MassMono: "85.016378" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01169 ! L-3-oxoalanine + +[Term] +id: MOD:00194 +name: lactic acid +def: "A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid." [PubMed:7607233, RESID:AA0186, UniMod:403#S] +synonym: "(2R)-2-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-hydroxypropionic acid" EXACT RESID-alternate [] +synonym: "alpha-hydroxypropionic acid" EXACT RESID-alternate [] +synonym: "Lac(Ser)" EXACT PSI-MOD-label [] +synonym: "lactic acid" EXACT RESID-name [] +synonym: "lactic acid from N-term Ser" RELATED UniMod-description [] +synonym: "MOD_RES Lactic acid" EXACT UniProt-feature [] +synonym: "Ser->LacticAcid" RELATED PSI-MS-label [] +xref: DiffAvg: "-15.02" +xref: DiffFormula: "C 0 H -1 N -1 O 0" +xref: DiffMono: "-15.010899" +xref: Formula: "C 3 H 5 O 2" +xref: MassAvg: "73.07" +xref: MassMono: "73.028954" +xref: Origin: "S" +xref: TermSpec: "N-term" +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00195 +name: L-alanine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine." [PubMed:10220322, RESID:AA0187] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "(2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "4-methylidene-imidazole-5-one active site" EXACT RESID-alternate [] +synonym: "alanyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-imidazolinone (Ala-Gly)" EXACT UniProt-feature [] +synonym: "L-alanine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "XLNK-1Ala-NGly(Imidazole)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 6 N 2 O 1" +xref: MassAvg: "110.12" +xref: MassMono: "110.048013" +xref: Origin: "A, G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00196 +name: L-cysteine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine." [PubMed:1537807, RESID:AA0188] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "(2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-imidazolinone (Cys-Gly)" EXACT UniProt-feature [] +synonym: "cysteinyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "L-cysteine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "XLNK-1Cys-NGly(Imidazole)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 6 N 2 O 1 S 1" +xref: MassAvg: "142.18" +xref: MassMono: "142.020084" +xref: Origin: "C, G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00197 +name: 2-imino-glutamine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine." [PubMed:11050230, PubMed:11209050, RESID:AA0189] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "2,N-didehydroglutaminyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "2-imino-glutamine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "[2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] +synonym: "[2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly)" EXACT UniProt-feature [] +synonym: "fluorescent protein FP583 chromophore" EXACT RESID-alternate [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "red fluorescent protein chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 7 N 3 O 2" +xref: MassAvg: "165.15" +xref: MassMono: "165.053826" +xref: Origin: "G, Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00198 +name: D-alanine (Ala) +def: "A protein modification that effectively converts an L-alanine residue to D-alanine." [PubMed:15023056, PubMed:7287302, PubMed:7961627, RESID:AA0191#ALA] +synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "D-Ala(Ala)" EXACT PSI-MOD-label [] +synonym: "D-alanine" EXACT RESID-name [] +synonym: "MOD_RES D-alanine (Ala)" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00570 ! residues isobaric at 71.037114 Da +is_a: MOD:00862 ! D-alanine +is_a: MOD:00901 ! modified L-alanine residue + +[Term] +id: MOD:00199 +name: D-allo-isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine." [ChEBI:30007, PubMed:8223491, RESID:AA0192] +synonym: "(2R,3S)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "3-methyl-norvaline" EXACT RESID-alternate [] +synonym: "allo-D-isoleucine" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate [] +synonym: "D-allo-isoleucine" EXACT RESID-name [] +synonym: "D-Ile" EXACT PSI-MOD-label [] +synonym: "D-threo-isoleucine" EXACT RESID-alternate [] +synonym: "MOD_RES D-allo-isoleucine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00306 ! residues isobaric at 113.084064 Da +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00910 ! modified L-isoleucine residue + +[Term] +id: MOD:00200 +name: D-methionine +def: "A protein modification that effectively converts an L-methionine residue to D-methionine." [ChEBI:29984, PubMed:16033333, PubMed:2542051, RESID:AA0193] +synonym: "(2R)-2-amino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-4-(methylthio)butyric acid" EXACT RESID-alternate [] +synonym: "D-Met" EXACT PSI-MOD-label [] +synonym: "D-methionine" EXACT RESID-name [] +synonym: "MOD_RES D-methionine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "131.19" +xref: MassMono: "131.040485" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00201 +name: D-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine." [ChEBI:29996, PubMed:1548227, PubMed:1644179, PubMed:2597281, RESID:AA0194] +synonym: "(R)-2-amino-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "D-Phe" EXACT PSI-MOD-label [] +synonym: "D-phenylalanine" EXACT RESID-name [] +synonym: "MOD_RES D-phenylalanine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 9 H 9 N 1 O 1" +xref: MassAvg: "147.18" +xref: MassMono: "147.068414" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:00202 +name: D-serine (Ser) +def: "A protein modification that effectively converts an L-serine residue to D-serine." [PubMed:7973665, RESID:AA0195#SER] +synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "D-Ser(Ser)" EXACT PSI-MOD-label [] +synonym: "D-serine" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 3 H 5 N 1 O 2" +xref: MassAvg: "87.08" +xref: MassMono: "87.032028" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00891 ! D-serine +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00203 +name: D-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to D-asparagine." [ChEBI:29957, PubMed:1859408, RESID:AA0196] +synonym: "(R)-2-amino-4-butanediamic acid" EXACT RESID-systematic [] +synonym: "D-alpha-aminosuccinamic acid" EXACT RESID-alternate [] +synonym: "D-Asn" EXACT PSI-MOD-label [] +synonym: "D-asparagine" EXACT RESID-name [] +synonym: "D-aspartic acid beta-amide" EXACT RESID-alternate [] +synonym: "MOD_RES D-asparagine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 4 H 6 N 2 O 2" +xref: MassAvg: "114.10" +xref: MassMono: "114.042927" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00204 +name: D-leucine +def: "A protein modification that effectively converts an L-leucine residue to D-leucine." [ChEBI:30005, PubMed:10461743, PubMed:12135762, PubMed:1358533, PubMed:1548227, RESID:AA0197] +synonym: "(2R)-2-amino-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "alpha-aminoisocaproic acid" EXACT RESID-alternate [] +synonym: "D-Leu" EXACT PSI-MOD-label [] +synonym: "D-leucine" EXACT RESID-name [] +synonym: "MOD_RES D-leucine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00306 ! residues isobaric at 113.084064 Da +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00911 ! modified L-leucine residue + +[Term] +id: MOD:00205 +name: D-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to D-tryptophan." [ChEBI:29955, PubMed:8910408, RESID:AA0198] +synonym: "(R)-2-amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "alpha-amino-beta-(3-indolyl)propionoic acid" EXACT RESID-alternate [] +synonym: "D-Trp" EXACT PSI-MOD-label [] +synonym: "D-tryptophan" EXACT RESID-name [] +synonym: "MOD_RES D-tryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 11 H 10 N 2 O 1" +xref: MassAvg: "186.21" +xref: MassMono: "186.079313" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00206 +name: L-isoglutamyl-polyglycine +def: "A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine." [ChEBI:21343, PubMed:10074368, PubMed:16368691, PubMed:7992051, RESID:AA0201] +synonym: "gamma-glutamylpolyglycine" EXACT RESID-alternate [] +synonym: "L-isoglutamyl-polyglycine" EXACT RESID-name [] +synonym: "MOD_RES 5-glutamyl polyglycine" EXACT UniProt-feature [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "C 7 H 10 N 2 O 4" +xref: MassAvg: "186.17" +xref: MassMono: "186.064057" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00207 +name: L-isoglutamyl-polyglutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid." [PubMed:10747868, PubMed:1680872, RESID:AA0202] +synonym: "gamma-glutamylpolyglutamic acid" EXACT RESID-alternate [] +synonym: "L-isoglutamyl-polyglutamic acid" EXACT RESID-name [] +xref: DiffAvg: "129.12" +xref: DiffFormula: "C 5 H 7 N 1 O 3" +xref: DiffMono: "129.042593" +xref: Formula: "C 10 H 14 N 2 O 6" +xref: MassAvg: "258.23" +xref: MassMono: "258.085186" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00674 ! amidated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00208 +name: O4'-(phospho-5'-adenosine)-L-tyrosine +def: "A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine." [DeltaMass:0, PubMed:5543675, RESID:AA0203, UniMod:405#Y] +comment: From DeltaMass: Average Mass: 329. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "5'-adenylic-O-tyrosine" EXACT RESID-alternate [] +synonym: "AMP binding site" RELATED UniMod-description [] +synonym: "hydrogen 5'-adenylate tyrosine ester" EXACT RESID-alternate [] +synonym: "MOD_RES O-AMP-tyrosine" EXACT UniProt-feature [] +synonym: "O-5'-Adenosylation ( of Tyrosine)" EXACT DeltaMass-label [] +synonym: "O4'-(phospho-5'-adenosine)-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-L-tyrosine 5'-adenosine phosphodiester" EXACT RESID-alternate [] +synonym: "OAMPTyr" EXACT PSI-MOD-label [] +synonym: "Phosphoadenosine" RELATED PSI-MS-label [] +xref: DiffAvg: "329.21" +xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" +xref: DiffMono: "329.052520" +xref: Formula: "C 19 H 21 N 6 O 8 P 1" +xref: MassAvg: "492.38" +xref: MassMono: "492.115848" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01165 ! adenylated residue + +[Term] +id: MOD:00209 +name: S-(2-aminovinyl)-D-cysteine (Cys-Ser) +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [PubMed:3181159, PubMed:3769923, RESID:AA0204#SER] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] +synonym: "CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys)" EXACT UniProt-feature [] +synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name [] +synonym: "XLNK-(D)SCys-VinAm" EXACT PSI-MOD-label [] +xref: DiffAvg: "-64.04" +xref: DiffFormula: "C -1 H -4 N 0 O -3 S 0" +xref: DiffMono: "-64.016044" +xref: Formula: "C 5 H 7 N 2 O 1 S 1" +xref: MassAvg: "143.18" +xref: MassMono: "143.027909" +xref: Origin: "C, S" +xref: TermSpec: "C-term" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01850 ! S-(2-aminovinyl)-D-cysteine + +[Term] +id: MOD:00210 +name: L-cysteine sulfenic acid +def: "A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid." [DeltaMass:41, OMSSA:193, PubMed:10964927, PubMed:2501303, PubMed:8756456, PubMed:9214307, PubMed:9586994, PubMed:9587003, RESID:AA0205, UniMod:35#C] +comment: From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH). +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-(hydroxysulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "(2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-2-carboxyethanesulfenic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-sulfinylpropanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "3-sulfenoalanine" EXACT RESID-alternate [] +synonym: "ACT_SITE Cysteine sulfenic acid (-SOH) intermediate" EXACT UniProt-feature [] +synonym: "CysOH" EXACT PSI-MOD-label [] +synonym: "cysteine S-oxide [tautomer]" EXACT RESID-alternate [] +synonym: "cysteine sulfoxide [tautomer]" EXACT RESID-alternate [] +synonym: "cysteine sulphenic acid" EXACT RESID-alternate [] +synonym: "L-cysteine sulfenic acid" EXACT RESID-name [] +synonym: "mod193" EXACT OMSSA-label [] +synonym: "MOD_RES Cysteine sulfenic acid (-SOH)" EXACT UniProt-feature [] +synonym: "Oxidation" RELATED PSI-MS-label [] +synonym: "S-hydroxycysteine" EXACT RESID-alternate [] +synonym: "S-oxocysteine [tautomer]" EXACT RESID-alternate [] +synonym: "S-oxycysteine [tautomer]" EXACT RESID-alternate [] +synonym: "Sulfenic Acid (from Cysteine)" EXACT DeltaMass-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" +xref: DiffMono: "15.994915" +xref: Formula: "C 3 H 5 N 1 O 2 S 1" +xref: MassAvg: "119.14" +xref: MassMono: "119.004099" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:01854 ! sulfur monooxygenated residue + +[Term] +id: MOD:00211 +name: S-(glycyl)-L-cysteine (Cys-Gly) +def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine." [ChEBI:22050, PubMed:3306404, RESID:AA0206] +comment: Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cycteine see MOD:01777 [JSG]. +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid" EXACT RESID-systematic [] +synonym: "1-(cystein-S-yl)-glycinate" EXACT RESID-alternate [] +synonym: "ACT_SITE Glycyl thioester intermediate" EXACT UniProt-feature [] +synonym: "glycine cysteine thioester" EXACT RESID-alternate [] +synonym: "S-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(glycyl)-L-cysteine" EXACT RESID-name [] +synonym: "XLNK-SCys-1Gly" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 7 N 2 O 2 S 1" +xref: MassAvg: "159.18" +xref: MassMono: "159.022823" +xref: Origin: "C, G" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00212 +name: S-4-hydroxycinnamyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine." [PubMed:7947803, PubMed:7981196, RESID:AA0207, UniMod:407] +synonym: "(2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "cinnamate cysteine thioester" EXACT RESID-alternate [] +synonym: "Hydroxycinnamyl" RELATED PSI-MS-label [] +synonym: "hydroxycinnamyl" RELATED UniMod-description [] +synonym: "MOD_RES S-(4-hydroxycinnamyl)cysteine" EXACT UniProt-feature [] +synonym: "S-4-hydroxycinnamyl-L-cysteine" EXACT RESID-name [] +synonym: "S-para-coumaryl-L-cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "146.14" +xref: DiffFormula: "C 9 H 6 N 0 O 2 S 0" +xref: DiffMono: "146.036779" +xref: Formula: "C 12 H 11 N 1 O 3 S 1" +xref: MassAvg: "249.28" +xref: MassMono: "249.045964" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00213 +name: chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +def: "A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:1794445, PubMed:1898736, PubMed:3472204, RESID:AA0208] +synonym: "chondroitin 4-sulfate (chondroitin sulfate A)" EXACT RESID-alternate [] +synonym: "chondroitin 6-sulfate (chondroitin sulfate C)" EXACT RESID-alternate [] +synonym: "chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name [] +synonym: "poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007825" +xref: Formula: "C 3 H 4 N 1 O 2" +xref: MassAvg: "86.07" +xref: MassMono: "86.024203" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:00214 +name: dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +def: "A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:2914936, PubMed:3472204, RESID:AA0209] +synonym: "beta-heparin" EXACT RESID-alternate [] +synonym: "chondroitin sulfate B" EXACT RESID-alternate [] +synonym: "dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name [] +synonym: "poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007825" +xref: Formula: "C 3 H 4 N 1 O 2" +xref: MassAvg: "86.07" +xref: MassMono: "86.024203" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:00215 +name: heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +def: "A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:3472204, RESID:AA0210] +synonym: "heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name [] +synonym: "heparin" EXACT RESID-alternate [] +synonym: "heparitin sulfate" EXACT RESID-alternate [] +synonym: "poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007825" +xref: Formula: "C 3 H 4 N 1 O 2" +xref: MassAvg: "86.07" +xref: MassMono: "86.024203" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:00216 +name: N6-formyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine." [OMSSA:43, PubMed:15799070, RESID:AA0211, UniMod:122#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(formylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "epsilon-formyllysine" EXACT RESID-alternate [] +synonym: "Formyl" RELATED PSI-MS-label [] +synonym: "Formylation" RELATED UniMod-description [] +synonym: "formylk" EXACT OMSSA-label [] +synonym: "MOD_RES N6-formyllysine" EXACT UniProt-feature [] +synonym: "N(zeta)-formyllysine" EXACT RESID-alternate [] +synonym: "N6-formyl-L-lysine" EXACT RESID-name [] +synonym: "N6-formylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6FoLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 7 H 12 N 2 O 2" +xref: MassAvg: "156.19" +xref: MassMono: "156.089878" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00217 +name: O4-arabinosyl-L-hydroxyproline +def: "A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline." [DeltaMass:0, PubMed:666730, PubMed:7852316, RESID:AA0212, UniMod:408] +comment: secondary to RESID:AA0030; From DeltaMass: Average Mass: 147. +subset: PSI-MOD-slim +synonym: "(2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "4-(beta-L-arabinofuranosyloxy)proline" EXACT RESID-alternate [] +synonym: "4-Glycosyloxy- (pentosyl,C5) (of Proline)" EXACT DeltaMass-label [] +synonym: "beta-arabinofuranosyl-4-hydroxyproline" EXACT RESID-alternate [] +synonym: "Glycosyl" RELATED PSI-MS-label [] +synonym: "glycosyl-L-hydroxyproline" RELATED UniMod-description [] +synonym: "O4-arabinosyl-L-hydroxyproline" EXACT RESID-name [] +synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate [] +synonym: "OAra4HyPro" EXACT PSI-MOD-label [] +xref: DiffAvg: "148.11" +xref: DiffFormula: "C 5 H 8 N 0 O 5" +xref: DiffMono: "148.037173" +xref: Formula: "C 10 H 15 N 1 O 6" +xref: MassAvg: "245.23" +xref: MassMono: "245.089937" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00396 ! O-glycosylated residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00218 +name: O-(phospho-5'-RNA)-L-serine +def: "A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine." [PubMed:1705009, RESID:AA0213] +synonym: "(S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES O-(5'-phospho-RNA)-serine" EXACT UniProt-feature [] +synonym: "O-(phospho-5'-RNA)-L-serine" EXACT RESID-name [] +synonym: "O3-(phospho-5'-RNA)-L-serine" EXACT RESID-alternate [] +synonym: "O3-L-serine 5'-RNA phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "78.97" +xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1" +xref: DiffMono: "78.958505" +xref: Formula: "C 3 H 5 N 1 O 5 P 1" +xref: MassAvg: "166.05" +xref: MassMono: "165.990534" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00751 ! ribonucleic acid linked residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00219 +name: L-citrulline +def: "A protein modification that effectively converts an L-arginine residue to L-citrulline." [DeltaMass:0, OMSSA:33, PubMed:2466844, RESID:AA0214, UniMod:7#R] +comment: This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group. +subset: PSI-MOD-slim +synonym: "(S)-2-amino-5-(carbamoylamino)pentanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-5-(aminocarbonyl)aminopentanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-delta-ureidovaleric acid" EXACT RESID-alternate [] +synonym: "Cit" EXACT PSI-MOD-label [] +synonym: "citrullinationr" EXACT OMSSA-label [] +synonym: "Citrulline" EXACT DeltaMass-label [] +synonym: "Deamidated" RELATED PSI-MS-label [] +synonym: "Deamidated" RELATED UniMod-interim [] +synonym: "Deamidation" RELATED UniMod-description [] +synonym: "delta-ureidonorvaline" EXACT RESID-alternate [] +synonym: "L-citrulline" EXACT RESID-name [] +synonym: "MOD_RES Citrulline" EXACT UniProt-feature [] +synonym: "N5-(aminocarbonyl)ornithine" EXACT RESID-alternate [] +synonym: "N5-carbamoylornithine" EXACT RESID-alternate [] +synonym: "N5-carbamylornithine" EXACT RESID-alternate [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "C 0 H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "C 6 H 11 N 3 O 2" +xref: MassAvg: "157.17" +xref: MassMono: "157.085127" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00220 +name: 4-hydroxy-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine." [PubMed:10966817, PubMed:7650037, RESID:AA0215] +synonym: "(2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-5-guanidino-4-hydroxypentanoic acid" EXACT RESID-alternate [] +synonym: "4-hydroxy-L-arginine" EXACT RESID-name [] +synonym: "4-hydroxylated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "4HyArg" EXACT PSI-MOD-label [] +synonym: "C(gamma)-hydroxyarginine" EXACT RESID-alternate [] +synonym: "gamma-hydroxyarginine" EXACT RESID-alternate [] +synonym: "MOD_RES 4-hydroxyarginine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 4 O 2" +xref: MassAvg: "172.19" +xref: MassMono: "172.096026" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00682 ! hydroxylated arginine + +[Term] +id: MOD:00221 +name: N-(L-isoaspartyl)-L-cysteine +def: "A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine." [PubMed:8286361, RESID:AA0216] +comment: Cross-link 2. +synonym: "(S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn)" EXACT UniProt-feature [] +synonym: "N-(L-isoaspartyl)-L-cysteine" EXACT RESID-name [] +synonym: "N-beta-aspartylcysteine" EXACT RESID-alternate [] +synonym: "N-isoaspartyl cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 7 H 9 N 2 O 3 S 1" +xref: MassAvg: "201.22" +xref: MassMono: "201.033388" +xref: Origin: "C, N" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00222 +name: 2'-alpha-mannosyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan." [PubMed:15279557, PubMed:7547911, PubMed:7947762, RESID:AA0217, UniMod:41#W] +synonym: "(2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "2'-mannosyl-L-tryptophan" EXACT RESID-name [] +synonym: "2'-tryptophan C-mannoside" EXACT RESID-alternate [] +synonym: "C2'ManTrp" EXACT PSI-MOD-label [] +synonym: "CARBOHYD C-linked (Man)" EXACT UniProt-feature [] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 17 H 20 N 2 O 6" +xref: MassAvg: "348.36" +xref: MassMono: "348.132136" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00421 ! C-glycosylated residue +is_a: MOD:00595 ! mannosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00223 +name: N6-mureinyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine." [PubMed:4261992, RESID:AA0218] +synonym: "MOD_RES N6-murein peptidoglycan lysine" EXACT UniProt-feature [] +synonym: "N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine" EXACT RESID-alternate [] +synonym: "N6-mureinyl-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007825" +xref: Formula: "C 6 H 11 N 2 O 1" +xref: MassAvg: "127.17" +xref: MassMono: "127.087138" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01159 ! peptidoglycanated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00224 +name: 1-chondroitin sulfate-L-aspartic acid ester +def: "A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester" [PubMed:1898736, RESID:AA0219] +synonym: "1-aspartic acid ester with 6-chondroitin 4-sulfate" EXACT RESID-alternate [] +synonym: "1-chondroitin sulfate-L-aspartic acid ester" EXACT RESID-name [] +synonym: "MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester" EXACT UniProt-feature [] +synonym: "poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose)" EXACT RESID-alternate [] +synonym: "protein-glycosaminoglycan-protein cross-link" EXACT RESID-alternate [] +xref: DiffAvg: "441.36" +xref: DiffFormula: "C 14 H 19 N 1 O 13 S 1" +xref: DiffMono: "441.057711" +xref: Formula: "C 18 H 25 N 2 O 17 S 1" +xref: MassAvg: "573.45" +xref: MassMono: "573.087393" +xref: Origin: "D" +xref: TermSpec: "C-term" +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:00225 +name: S-(6-FMN)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine." [PubMed:10869173, PubMed:1551870, PubMed:620783, RESID:AA0220, UniMod:409#C] +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "6-[S-cysteinyl]flavin mononucleotide" EXACT RESID-alternate [] +synonym: "6-[S-cysteinyl]FMN" EXACT RESID-alternate [] +synonym: "flavin mononucleotide" RELATED UniMod-description [] +synonym: "FMNH" RELATED PSI-MS-label [] +synonym: "MOD_RES S-6-FMN cysteine" EXACT UniProt-feature [] +synonym: "S-(6-FMN)-L-cysteine" EXACT RESID-name [] +synonym: "S6FMNCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "454.33" +xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1 S 0" +xref: DiffMono: "454.088965" +xref: Formula: "C 20 H 24 N 5 O 10 P 1 S 1" +xref: MassAvg: "557.47" +xref: MassMono: "557.098150" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00896 ! FMN modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00226 +name: 1'-(8alpha-FAD)-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine." [DeltaMass:0, PubMed:10585424, PubMed:1396672, PubMed:4339951, PubMed:9261083, RESID:AA0221, UniMod:50#H] +comment: From DeltaMass: Average Mass: 784 +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1'-(8alpha-FAD)-L-histidine" EXACT RESID-name [] +synonym: "8alpha-(N(epsilon)-histidyl)FAD" EXACT RESID-alternate [] +synonym: "8alpha-(N1'-histidyl)FAD" EXACT RESID-alternate [] +synonym: "8alpha-N3-histidyl FAD" RELATED RESID-misnomer [] +synonym: "FAD" RELATED PSI-MS-label [] +synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] +synonym: "MOD_RES Tele-8alpha-FAD histidine" EXACT UniProt-feature [] +synonym: "N theta and N pi-(8alpha-Flavin) (on Histidine)" EXACT DeltaMass-label [] +synonym: "N(tau)-(8alpha-FAD)-histidine" EXACT RESID-alternate [] +synonym: "Nt8aFADHis" EXACT PSI-MOD-label [] +synonym: "tele-(8alpha-FAD)-histidine" EXACT RESID-alternate [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" +xref: DiffMono: "783.141485" +xref: Formula: "C 33 H 38 N 12 O 16 P 2" +xref: MassAvg: "920.68" +xref: MassMono: "920.200396" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00227 +name: omega-N-phospho-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine." [PubMed:8300603, RESID:AA0222, UniMod:21#R] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-delta-phosphonoguanidinovaleric acid" EXACT RESID-alternate [] +synonym: "MOD_RES Phosphoarginine" EXACT UniProt-feature [] +synonym: "N(gamma)-phosphoarginine" EXACT RESID-alternate [] +synonym: "N(omega)-phosphono-L-arginine" EXACT RESID-alternate [] +synonym: "N5-[imino(phosphonoamino)methyl]-L-ornithine" EXACT RESID-alternate [] +synonym: "omega-N-phospho-L-arginine" EXACT RESID-name [] +synonym: "PArg" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "phosphoarginine" EXACT RESID-alternate [] +synonym: "Phosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 6 H 13 N 4 O 4 P 1" +xref: MassAvg: "236.17" +xref: MassMono: "236.067442" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01456 ! N-phosphorylated residue + +[Term] +id: MOD:00228 +name: S-diphytanylglycerol diether-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine." [PubMed:7797461, PubMed:8195126, RESID:AA0223, UniMod:410] +comment: incidental to RESID:AA0043. +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "Archaeol" RELATED PSI-MS-label [] +synonym: "LIPID S-archaeol cysteine" EXACT UniProt-feature [] +synonym: "S-(diphytanylglyceryl)-L-cysteine" EXACT RESID-name [] +synonym: "S-[2',3'-bis(phytanyloxy)propyl]cysteine" EXACT RESID-alternate [] +synonym: "S-archaeol cysteine" EXACT RESID-alternate [] +synonym: "S-diphytanylglycerol diether" RELATED UniMod-description [] +synonym: "SPhyt2GlyceroCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "635.16" +xref: DiffFormula: "C 43 H 86 N 0 O 2 S 0" +xref: DiffMono: "634.662782" +xref: Formula: "C 46 H 91 N 1 O 3 S 1" +xref: MassAvg: "738.30" +xref: MassMono: "737.671967" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00229 +name: alpha-1-microglobulin-Ig alpha complex chromophore +def: "A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore." [PubMed:11058759, PubMed:11877257, PubMed:7506257, PubMed:7535251, RESID:AA0224] +comment: Cross-link 2. +synonym: "alpha-1-microglobulin-Ig alpha complex chromophore" EXACT RESID-name [] +synonym: "BINDING Multimeric 3-hydroxykynurenine chromophore (covalent)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 2 S 2" +xref: MassAvg: "204.26" +xref: MassMono: "204.002720" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00230 +name: bis-L-cysteinyl bis-L-histidino diiron disulfide +def: "A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide." [PubMed:2765515, PubMed:9651245, RESID:AA0225] +comment: Cross-link 4. +synonym: "bis-L-cysteinyl bis-L-histidino diiron disulfide" EXACT RESID-name [] +synonym: "di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron)" EXACT RESID-systematic [] +synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (2Fe-2S); via pros nitrogen" EXACT UniProt-feature [] +synonym: "Rieske iron-sulfur cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "171.78" +xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" +xref: DiffMono: "171.783814" +xref: FormalCharge: "2-" +xref: Formula: "C 18 Fe 2 H 20 N 8 O 4 S 4" +xref: MassAvg: "652.34" +xref: MassMono: "651.920007" +xref: Origin: "C, C, H, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00231 +name: hexakis-L-cysteinyl hexairon hexasulfide +def: "A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide." [PubMed:1311311, PubMed:1318833, RESID:AA0226] +comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon" EXACT RESID-systematic [] +synonym: "hexa-mu3-sulfido-hexakis(S-cysteinyliron)" EXACT RESID-alternate [] +synonym: "hexakis-L-cysteinyl hexairon hexasulfide" EXACT RESID-name [] +synonym: "prismane iron-sulfur cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "521.38" +xref: DiffFormula: "C 0 Fe 6 H -6 N 0 O 0 S 6" +xref: DiffMono: "521.395649" +xref: FormalCharge: "1-" +xref: Formula: "C 18 Fe 6 H 24 N 6 O 6 S 12" +xref: MassAvg: "1140.22" +xref: MassMono: "1139.450758" +xref: Origin: "C, C, C, C, C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00232 +name: N6-(phospho-5'-adenosine)-L-lysine +def: "A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine." [DeltaMass:316, PubMed:3882425, PubMed:4944632, RESID:AA0227, UniMod:405#K] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "5'-adenylic-N6-L-lysine" EXACT RESID-alternate [] +synonym: "ACT_SITE N6-AMP-lysine intermediate" EXACT UniProt-feature [] +synonym: "AMP binding site" RELATED UniMod-description [] +synonym: "AMP Lysyl" EXACT DeltaMass-label [] +synonym: "epsilon-5'-adenylic-L-lysine" EXACT RESID-alternate [] +synonym: "L-lysine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] +synonym: "N(zeta)-5'-adenylic-L-lysine" EXACT RESID-alternate [] +synonym: "N6-(phospho-5'-adenosine)-L-lysine" EXACT RESID-name [] +synonym: "N6-L-lysine 5'-adenosine phosphoramidester" EXACT RESID-alternate [] +synonym: "N6AMPLys" EXACT PSI-MOD-label [] +synonym: "Phosphoadenosine" RELATED PSI-MS-label [] +xref: DiffAvg: "329.21" +xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" +xref: DiffMono: "329.052520" +xref: Formula: "C 16 H 24 N 7 O 7 P 1" +xref: MassAvg: "457.38" +xref: MassMono: "457.147483" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01165 ! adenylated residue + +[Term] +id: MOD:00233 +name: N6-(phospho-5'-guanosine)-L-lysine +def: "A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine." [DeltaMass:304, PubMed:6092377, PubMed:6264433, RESID:AA0228, UniMod:413#K] +comment: From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "5'-guanylic-N6-L-lysine" EXACT RESID-alternate [] +synonym: "5'phos Guanosyl" EXACT DeltaMass-label [] +synonym: "ACT_SITE N6-GMP-lysine intermediate" EXACT UniProt-feature [] +synonym: "epsilon-5'-guanylic-L-lysine" EXACT RESID-alternate [] +synonym: "L-lysine monoanhydride with 5'-guanylic acid" EXACT RESID-alternate [] +synonym: "lysine guanosine-5'-monophosphate" EXACT RESID-alternate [] +synonym: "N(zeta)-5'-guanylic-lysine" EXACT RESID-alternate [] +synonym: "N6-(5'-guanylyl)-lysine" EXACT RESID-alternate [] +synonym: "N6-(phospho-5'-guanosine)-L-lysine" EXACT RESID-name [] +synonym: "N6-L-lysine 5'-guanosine phosphoramidester" EXACT RESID-alternate [] +synonym: "N6GMPLys" EXACT PSI-MOD-label [] +synonym: "phospho-guanosine" RELATED UniMod-description [] +synonym: "Phosphoguanosine" RELATED PSI-MS-label [] +xref: DiffAvg: "345.21" +xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1" +xref: DiffMono: "345.047434" +xref: Formula: "C 16 H 24 N 7 O 8 P 1" +xref: MassAvg: "473.38" +xref: MassMono: "473.142397" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01163 ! guanylated residue + +[Term] +id: MOD:00234 +name: L-cysteine glutathione disulfide +def: "A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine." [ChEBI:21264, DeltaMass:0, OMSSA:51, PubMed:3083866, PubMed:8344916, RESID:AA0229, UniMod:55] +comment: From DeltaMass: Average Mass: 305 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid" EXACT RESID-systematic [] +synonym: "cysteinyl glutathione" EXACT RESID-alternate [] +synonym: "Glutathionation" EXACT DeltaMass-label [] +synonym: "Glutathione" RELATED PSI-MS-label [] +synonym: "glutathione disulfide" RELATED UniMod-description [] +synonym: "glutathionec" EXACT OMSSA-label [] +synonym: "L-cysteine glutathione disulfide" EXACT RESID-name [] +synonym: "L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine" EXACT RESID-alternate [] +synonym: "MOD_RES S-glutathionyl cysteine" EXACT UniProt-feature [] +synonym: "N-(N-gamma-glutamyl-cystinyl)-glycine" EXACT RESID-alternate [] +synonym: "SGltCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "305.30" +xref: DiffFormula: "C 10 H 15 N 3 O 6 S 1" +xref: DiffMono: "305.068156" +xref: Formula: "C 13 H 20 N 4 O 7 S 2" +xref: MassAvg: "408.44" +xref: MassMono: "408.077341" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01862 ! disulfide conjugated residue + +[Term] +id: MOD:00235 +name: S-nitrosyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine." [PubMed:10442087, PubMed:11562475, PubMed:15688001, PubMed:8626764, PubMed:8637569, RESID:AA0230, UniMod:275] +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-nitrososulfanyl-propanoic acid" EXACT RESID-systematic [] +synonym: "L-cysteine nitrite ester" EXACT RESID-alternate [] +synonym: "MOD_RES S-nitrosocysteine" EXACT UniProt-feature [] +synonym: "Nitrosyl" RELATED PSI-MS-label [] +synonym: "S-nitrosocysteine" EXACT RESID-alternate [] +synonym: "S-nitrosyl-L-cysteine" EXACT RESID-name [] +synonym: "S-nitrosylation" RELATED UniMod-description [] +synonym: "SNOCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "29.00" +xref: DiffFormula: "C 0 H -1 N 1 O 1 S 0" +xref: DiffMono: "28.990164" +xref: Formula: "C 3 H 4 N 2 O 2 S 1" +xref: MassAvg: "132.14" +xref: MassMono: "131.999348" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00236 +name: N4-(ADP-ribosyl)-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine." [PubMed:15842200, PubMed:2498316, RESID:AA0231, UniMod:213#N] +synonym: "(S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "ADP Ribose addition" RELATED UniMod-description [] +synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] +synonym: "MOD_RES ADP-ribosylasparagine" EXACT UniProt-feature [] +synonym: "N4-(ADP-ribosyl)-L-asparagine" EXACT RESID-name [] +synonym: "N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 19 H 27 N 7 O 15 P 2" +xref: MassAvg: "655.41" +xref: MassMono: "655.104036" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00237 +name: L-beta-methylthioaspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid." [DeltaMass:61, OMSSA:13, OMSSA:26, PubMed:15473684, PubMed:8844851, RESID:AA0232, UniMod:39#D] +subset: PSI-MOD-slim +synonym: "(2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid" EXACT RESID-systematic [] +synonym: "3-(methylthio)-L-aspartic acid" EXACT RESID-name [] +synonym: "3-carboxy-S-methyl-cysteine" EXACT RESID-alternate [] +synonym: "3-methylthio-aspartic acid" EXACT RESID-alternate [] +synonym: "3MeSAsp" EXACT PSI-MOD-label [] +synonym: "beta-Methylthio-aspartic acid" EXACT DeltaMass-label [] +synonym: "beta-methylthio-aspartic acid" EXACT RESID-alternate [] +synonym: "Beta-methylthiolation" RELATED UniMod-description [] +synonym: "bmethylthiold" EXACT OMSSA-label [] +synonym: "Methylthio" RELATED UniMod-interim [] +synonym: "methythiold" EXACT OMSSA-label [] +synonym: "MOD_RES 3-methylthioaspartic acid" EXACT UniProt-feature [] +xref: DiffAvg: "46.09" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" +xref: DiffMono: "45.987721" +xref: Formula: "C 5 H 7 N 1 O 3 S 1" +xref: MassAvg: "161.18" +xref: MassMono: "161.014664" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01153 ! methylthiolated residue + +[Term] +id: MOD:00238 +name: 5'-(N6-L-lysine)-L-topaquinone +def: "A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone." [PubMed:8688089, RESID:AA0233] +comment: Cross-link 2; secondary to RESID:AA0147. +synonym: "1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione" EXACT RESID-systematic [] +synonym: "2'-(L-lys-N6-yl)-L-4',5'-topaquinone" EXACT RESID-name [] +synonym: "2'-(L-lysine)-L-tyrosyl-4',5'-quinone" EXACT RESID-alternate [] +synonym: "CROSSLNK Lysine tyrosylquinone (Lys-Tyr)" EXACT UniProt-feature [] +synonym: "CROSSLNK Lysine tyrosylquinone (Tyr-Lys)" EXACT UniProt-feature [] +synonym: "LTQ" EXACT RESID-alternate [] +synonym: "lysyl oxidase cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "11.97" +xref: DiffFormula: "C 0 H -4 N 0 O 1" +xref: DiffMono: "11.963614" +xref: Formula: "C 15 H 17 N 3 O 4" +xref: MassAvg: "303.32" +xref: MassMono: "303.121906" +xref: Origin: "K, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00239 +name: S-methyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine." [PubMed:10660523, PubMed:11875433, PubMed:1339288, RESID:AA0234, UniMod:34#C] +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-(methylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE S-methylcysteine intermediate" EXACT UniProt-feature [] +synonym: "L-3-(methylthio)alanine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES S-methylcysteine" EXACT UniProt-feature [] +synonym: "S-methyl-L-cysteine" EXACT RESID-name [] +synonym: "S-methylated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "SMeCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 4 H 7 N 1 O 1 S 1" +xref: MassAvg: "117.17" +xref: MassMono: "117.024835" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00654 ! S-methylated residue +is_a: MOD:01682 ! monomethylated L-cysteine + +[Term] +id: MOD:00240 +name: 4-hydroxy-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine." [PubMed:4005040, RESID:AA0235] +comment: This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2S,4R)-2,6-diamino-4-hydroxyhexanoic acid" EXACT RESID-systematic [] +synonym: "4-hydroxy-L-lysine" EXACT RESID-name [] +synonym: "4-hydroxylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "4HyLys" EXACT PSI-MOD-label [] +synonym: "alpha,epsilon-diamino-gamma-hydroxycaproic acid" EXACT RESID-alternate [] +synonym: "L-threo-gamma-hydroxylysine" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 2 O 2" +xref: MassAvg: "144.17" +xref: MassMono: "144.089878" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01047 ! monohydroxylated lysine + +[Term] +id: MOD:00241 +name: N4-hydroxymethyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine." [RESID:AA0236, UniMod:414] +comment: N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N4-hydroxymethylbutanediamic acid" EXACT RESID-alternate [] +synonym: "beta-hydroxymethylasparagine" EXACT RESID-alternate [] +synonym: "Hydroxymethyl" RELATED PSI-MS-label [] +synonym: "hydroxymethyl" RELATED UniMod-description [] +synonym: "N(gamma)-hydroxymethylasparagine" EXACT RESID-alternate [] +synonym: "N4-hydroxymethyl-L-asparagine" EXACT RESID-name [] +synonym: "N4-hydroxymethylasparagine" EXACT RESID-alternate [] +xref: DiffAvg: "30.03" +xref: DiffFormula: "C 1 H 2 N 0 O 1" +xref: DiffMono: "30.010565" +xref: Formula: "C 5 H 8 N 2 O 3" +xref: MassAvg: "144.13" +xref: MassMono: "144.053492" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00242 +name: O-(ADP-ribosyl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine." [PubMed:15842200, PubMed:3141412, RESID:AA0237, UniMod:213#S] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid" EXACT RESID-systematic [] +synonym: "ADP Ribose addition" RELATED UniMod-description [] +synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] +synonym: "MOD_RES ADP-ribosylserine" EXACT UniProt-feature [] +synonym: "O-(ADP-ribosyl)-L-serine" EXACT RESID-name [] +synonym: "O3-(ADP-ribosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine" EXACT RESID-alternate [] +synonym: "O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +synonym: "OADPRibSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 18 H 26 N 6 O 15 P 2" +xref: MassAvg: "628.38" +xref: MassMono: "628.093137" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00243 +name: L-cysteine oxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0238] +comment: Cross-link 2. +synonym: "2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid" EXACT RESID-alternate [] +synonym: "2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser)" EXACT UniProt-feature [] +synonym: "L-cysteine oxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 6 H 6 N 2 O 2 S 1" +xref: MassAvg: "170.19" +xref: MassMono: "170.014998" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00244 +name: L-cysteine oxazoline-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid." [PubMed:1880060, RESID:AA0239] +comment: Cross-link 2. +synonym: "(4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser)" EXACT UniProt-feature [] +synonym: "L-cysteine oxazoline-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) + +[Term] +id: MOD:00245 +name: glycine oxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0240] +comment: Cross-link 2. +synonym: "2-aminomethyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-azanylmethyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser)" EXACT UniProt-feature [] +synonym: "glycine oxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 5 H 4 N 2 O 2" +xref: MassAvg: "124.10" +xref: MassMono: "124.027277" +xref: Origin: "G, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00246 +name: glycine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid." [ChEBI:21276, PubMed:8183941, PubMed:8895467, RESID:AA0241] +comment: Cross-link 2. +synonym: "2-(aminomethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys)" EXACT UniProt-feature [] +synonym: "glycine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 5 H 4 N 2 O 1 S 1" +xref: MassAvg: "140.16" +xref: MassMono: "140.004434" +xref: Origin: "C, G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00247 +name: L-serine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0242] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys)" EXACT UniProt-feature [] +synonym: "L-serine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 6 H 6 N 2 O 2 S 1" +xref: MassAvg: "170.19" +xref: MassMono: "170.014998" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00248 +name: L-phenylalanine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0243] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys)" EXACT UniProt-feature [] +synonym: "L-phenylalanine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 12 H 10 N 2 O 1 S 1" +xref: MassAvg: "230.29" +xref: MassMono: "230.051384" +xref: Origin: "C, F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00249 +name: L-cysteine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0244] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys)" EXACT UniProt-feature [] +synonym: "L-cysteine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 6 H 6 N 2 O 1 S 2" +xref: MassAvg: "186.25" +xref: MassMono: "185.992155" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00250 +name: L-lysine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0245] +comment: Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "L-lysine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 9 H 13 N 3 O 1 S 1" +xref: MassAvg: "211.28" +xref: MassMono: "211.077933" +xref: Origin: "C, K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00251 +name: O-(phospho-5'-DNA)-L-serine +def: "A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine." [PubMed:7142163, PubMed:7265205, RESID:AA0246] +synonym: "(S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE O-(5'-phospho-DNA)-serine intermediate" EXACT UniProt-feature [] +synonym: "MOD_RES O-(5'-phospho-DNA)-serine" EXACT UniProt-feature [] +synonym: "O-(phospho-5'-DNA)-L-serine" EXACT RESID-name [] +synonym: "O3-(phospho-5'-DNA)-L-serine" EXACT RESID-alternate [] +synonym: "O3-L-serine 5'-DNA phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "78.97" +xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1" +xref: DiffMono: "78.958505" +xref: Formula: "C 3 H 5 N 1 O 5 P 1" +xref: MassAvg: "166.05" +xref: MassMono: "165.990534" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00750 ! deoxyribonucleic acid linked residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00252 +name: keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine +def: "A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:1417734, PubMed:3472204, RESID:AA0247] +synonym: "keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT RESID-name [] +synonym: "keratosulfate" EXACT RESID-alternate [] +synonym: "poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine" EXACT RESID-systematic [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007825" +xref: Formula: "C 4 H 6 N 1 O 2" +xref: MassAvg: "100.10" +xref: MassMono: "100.039853" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00005 ! O-glycosyl-L-threonine + +[Term] +id: MOD:00253 +name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec) +def: "A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:14235557, PubMed:2211698, PubMed:8052647, PubMed:9036855, RESID:AA0248#SEC, UniMod:415] +xref: DiffAvg: "1572.02" +xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0" +xref: DiffMono: "1572.985775" +xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1" +xref: MassAvg: "1722.07" +xref: MassMono: "1723.939410" +xref: Origin: "U" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00744 ! molybdenum pterin containing modification +is_a: MOD:01158 ! modified L-selenocysteine residue + +[Term] +id: MOD:00254 +name: O4'-(phospho-5'-RNA)-L-tyrosine +def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine." [PubMed:1702164, PubMed:209034, PubMed:217003, PubMed:6264310, RESID:AA0249] +synonym: "(S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES O-(5'-phospho-RNA)-tyrosine" EXACT UniProt-feature [] +synonym: "O4'-(phospho-5'-RNA)-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-L-tyrosine 5'-RNA phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 9 H 10 N 1 O 5 P 1" +xref: MassAvg: "243.15" +xref: MassMono: "243.029659" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00751 ! ribonucleic acid linked residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00255 +name: 3-(3'-L-histidyl)-L-tyrosine +def: "A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine." [PubMed:9144772, RESID:AA0250] +comment: Cross-link 2. +synonym: "(2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3-(3'-L-histidyl)-L-tyrosine" EXACT RESID-name [] +synonym: "3-(N3'-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "3-(pi-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "3-(pros-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "beta-(N(delta)-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "beta-(N3'-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 15 H 14 N 4 O 3" +xref: MassAvg: "298.30" +xref: MassMono: "298.106590" +xref: Origin: "H, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00256 +name: L-methionine sulfone +def: "A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone." [DeltaMass:205, OMSSA:115, PubMed:12686488, PubMed:7786407, PubMed:7791219, PubMed:9252331, RESID:AA0251, UniMod:425#M] +comment: DeltaMass gives the formula C 5 H 9 N 3 O 1 S 1 with mass 163 +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-(methylsulfonyl)butanoic acid" EXACT RESID-systematic [] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "L-methionine S,S-dioxide" EXACT RESID-alternate [] +synonym: "L-methionine sulfone" EXACT RESID-name [] +synonym: "MethionylSulphone" EXACT DeltaMass-label [] +synonym: "MetO2" EXACT PSI-MOD-label [] +synonym: "MOD_RES Methionine sulfone" EXACT UniProt-feature [] +synonym: "Oxidation of Methionine (to Sulphone)" EXACT DeltaMass-label [] +synonym: "S,S-dioxymethionine" EXACT RESID-alternate [] +synonym: "suphonem" EXACT OMSSA-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2 S 0" +xref: DiffMono: "31.989829" +xref: Formula: "C 5 H 9 N 1 O 3 S 1" +xref: MassAvg: "163.19" +xref: MassMono: "163.030314" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00709 ! sulfur oxygenated L-methionine +is_a: MOD:01855 ! sulfur dioxygenated residue + +[Term] +id: MOD:00257 +name: dipyrrolylmethanemethyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine." [PubMed:3042456, PubMed:3196304, PubMed:3421931, PubMed:8727319, RESID:AA0252, UniMod:416] +synonym: "(2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid" EXACT RESID-alternate [] +synonym: "dipyrrole cofactor" EXACT RESID-alternate [] +synonym: "Dipyrrolylmethanemethyl" RELATED PSI-MS-label [] +synonym: "dipyrrolylmethanemethyl" RELATED UniMod-description [] +synonym: "dipyrrolylmethanemethyl-L-cysteine" EXACT RESID-name [] +synonym: "dipyrrolylmethyl-L-cysteine" EXACT RESID-alternate [] +synonym: "dipyrromethane cofactor" EXACT RESID-alternate [] +synonym: "MOD_RES S-(dipyrrolylmethanemethyl)cysteine" EXACT UniProt-feature [] +synonym: "pyrromethane cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "418.40" +xref: DiffFormula: "C 20 H 22 N 2 O 8 S 0" +xref: DiffMono: "418.137616" +xref: Formula: "C 23 H 27 N 3 O 9 S 1" +xref: MassAvg: "521.54" +xref: MassMono: "521.146800" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00258 +name: S-(2-aminovinyl)-3-methyl-D-cysteine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine." [PubMed:9119018, RESID:AA0253] +comment: Cross-link 2. +synonym: "(2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys)" EXACT UniProt-feature [] +synonym: "decarboxylated methyllanthionine" EXACT RESID-alternate [] +synonym: "S-(2-aminovinyl)-3-methyl-D-cysteine" EXACT RESID-name [] +xref: DiffAvg: "-64.04" +xref: DiffFormula: "C -1 H -4 N 0 O -3 S 0" +xref: DiffMono: "-64.016044" +xref: Formula: "C 6 H 9 N 2 O 1 S 1" +xref: MassAvg: "157.21" +xref: MassMono: "157.043559" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00259 +name: O4'-(phospho-5'-DNA)-L-tyrosine +def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine." [PubMed:1861973, PubMed:2940511, PubMed:3684578, RESID:AA0254] +synonym: "(S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate" EXACT UniProt-feature [] +synonym: "MOD_RES O-(5'-phospho-DNA)-tyrosine" EXACT UniProt-feature [] +synonym: "O4'-(phospho-5'-DNA)-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-L-tyrosine 5'-DNA phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 9 H 10 N 1 O 5 P 1" +xref: MassAvg: "243.15" +xref: MassMono: "243.029659" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00750 ! deoxyribonucleic acid linked residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00260 +name: O-(phospho-5'-DNA)-L-threonine +def: "A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine." [PubMed:3081736, RESID:AA0255] +synonym: "(S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid" EXACT RESID-systematic [] +synonym: "O-(phospho-5'-DNA)-L-threonine" EXACT RESID-name [] +synonym: "O3-(phospho-5'-DNA)-L-threonine" EXACT RESID-alternate [] +synonym: "O3-L-threonine 5'-DNA phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "78.97" +xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1" +xref: DiffMono: "78.958505" +xref: Formula: "C 4 H 7 N 1 O 5 P 1" +xref: MassAvg: "180.08" +xref: MassMono: "180.006184" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00750 ! deoxyribonucleic acid linked residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00261 +name: O4'-(phospho-5'-uridine)-L-tyrosine +def: "A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine." [DeltaMass:0, PubMed:11467524, PubMed:2885322, RESID:AA0256, UniMod:417#Y] +comment: From DeltaMass: Average Mass: 306. +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "5'-uridylic-O-tyrosine" EXACT RESID-alternate [] +synonym: "hydrogen 5'-uridylate tyrosine ester" EXACT RESID-alternate [] +synonym: "MOD_RES O-UMP-tyrosine" EXACT UniProt-feature [] +synonym: "O-Uridinylylation (of Tyrosine)" EXACT DeltaMass-label [] +synonym: "O4'-(phospho-5'-uridine)-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-L-tyrosine 5'-uridine phosphodiester" EXACT RESID-alternate [] +synonym: "OUMPTyr" EXACT PSI-MOD-label [] +synonym: "PhosphoUridine" RELATED PSI-MS-label [] +synonym: "uridine phosphodiester" RELATED UniMod-description [] +xref: DiffAvg: "306.17" +xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1" +xref: DiffMono: "306.025302" +xref: Formula: "C 18 H 20 N 3 O 10 P 1" +xref: MassAvg: "469.34" +xref: MassMono: "469.088630" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01166 ! uridylated residue + +[Term] +id: MOD:00262 +name: N-(L-glutamyl)-L-tyrosine +def: "A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine." [ChEBI:21477, PubMed:6387372, PubMed:8093886, RESID:AA0257] +comment: Cross-link 2. +synonym: "(S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "L-glutamyl L-tyrosine" EXACT RESID-name [] +synonym: "N-(L-glutamyl)-L-tyrosine" EXACT RESID-alternate [] +synonym: "SITE Involved in polymerization" EXACT UniProt-feature [] +xref: DiffAvg: "-17.01" +xref: DiffFormula: "C 0 H -1 N 0 O -1" +xref: DiffMono: "-17.002740" +xref: Formula: "C 14 H 16 N 2 O 5" +xref: MassAvg: "292.29" +xref: MassMono: "292.105922" +xref: Origin: "E, Y" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00263 +name: S-phycoviolobilin-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin." [PubMed:2106585, PubMed:3208761, RESID:AA0258, UniMod:387] +synonym: "(4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione" EXACT RESID-systematic [] +synonym: "BINDING Phycoviolobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "cryptobiliviolin" EXACT RESID-alternate [] +synonym: "cryptoviolin" EXACT RESID-alternate [] +synonym: "cryptoviolobilin" EXACT RESID-alternate [] +synonym: "PBV" EXACT RESID-alternate [] +synonym: "Phycocyanobilin" RELATED PSI-MS-label [] +synonym: "phycocyanobilin" RELATED UniMod-description [] +synonym: "PVB" EXACT RESID-alternate [] +synonym: "PXB" EXACT RESID-alternate [] +synonym: "S-phycobiliviolin-L-cysteine" EXACT RESID-alternate [] +synonym: "S-phycoviolobilin-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "586.69" +xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" +xref: DiffMono: "586.279135" +xref: Formula: "C 36 H 43 N 5 O 7 S 1" +xref: MassAvg: "689.83" +xref: MassMono: "689.288320" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00264 +name: phycoerythrobilin-bis-L-cysteine +def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin." [PubMed:3208761, PubMed:3838747, RESID:AA0259] +comment: Cross-link 2. +synonym: "(2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] +synonym: "3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid" EXACT RESID-alternate [] +synonym: "BINDING Phycoerythrobilin chromophore (covalent; via 2 links)" EXACT UniProt-feature [] +synonym: "PEB" EXACT RESID-alternate [] +synonym: "phycoerythrobilin biscysteine adduct" EXACT RESID-alternate [] +synonym: "phycoerythrobilin-bis-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "586.69" +xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" +xref: DiffMono: "586.279135" +xref: Formula: "C 39 H 48 N 6 O 8 S 2" +xref: MassAvg: "792.97" +xref: MassMono: "792.297505" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00265 +name: phycourobilin-bis-L-cysteine +def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin." [PubMed:3208761, PubMed:3838665, PubMed:3838747, PubMed:8876649, RESID:AA0260] +comment: Cross-link 2. +synonym: "3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid" EXACT RESID-alternate [] +synonym: "3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione" EXACT RESID-systematic [] +synonym: "BINDING Phycourobilin chromophore (covalent; via 2 links)" EXACT UniProt-feature [] +synonym: "phycourobilin biscysteine adduct" EXACT RESID-alternate [] +synonym: "phycourobilin-bis-L-cysteine" EXACT RESID-name [] +synonym: "PUB" EXACT RESID-alternate [] +xref: DiffAvg: "586.69" +xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" +xref: DiffMono: "586.279135" +xref: Formula: "C 39 H 48 N 6 O 8 S 2" +xref: MassAvg: "792.97" +xref: MassMono: "792.297505" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00266 +name: N-L-glutamyl-poly-L-glutamic acid +def: "A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid." [PubMed:2570347, PubMed:328274, RESID:AA0261] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 10 H 15 N 2 O 7" +xref: MassAvg: "275.24" +xref: MassMono: "275.087926" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00267 +name: L-cysteine sulfinic acid +def: "A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid." [ChEBI:16345, OMSSA:162, PubMed:12686488, PubMed:9252331, PubMed:9586994, RESID:AA0262, UniMod:425#C] +comment: "Hyun Ae Woo, et. al., Science 300 (5619), 653-656" +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-sulfinopropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-2-carboxyethanesulfinic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-3-sulfonylpropanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "3-sulfinoalanine" EXACT RESID-alternate [] +synonym: "3-sulphinoalanine" EXACT RESID-alternate [] +synonym: "CysO2H" EXACT PSI-MOD-label [] +synonym: "cysteine sulphinic acid" EXACT RESID-alternate [] +synonym: "cysteine-S,S-dioxide [tautomer]" EXACT RESID-alternate [] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "L-cysteine sulfinic acid" EXACT RESID-name [] +synonym: "MOD_RES Cysteine sulfinic acid (-SO2H)" EXACT UniProt-feature [] +synonym: "S-cysteinesulfinic acid" EXACT RESID-alternate [] +synonym: "S-sulfinocysteine" EXACT RESID-alternate [] +synonym: "sulfinicacid" EXACT OMSSA-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2 S 0" +xref: DiffMono: "31.989829" +xref: Formula: "C 3 H 5 N 1 O 3 S 1" +xref: MassAvg: "135.14" +xref: MassMono: "134.999014" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:01855 ! sulfur dioxygenated residue + +[Term] +id: MOD:00268 +name: L-3',4',5'-trihydroxyphenylalanine +def: "A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine." [DeltaMass:0, PubMed:12686488, PubMed:12771378, PubMed:8554314, PubMed:9252331, PubMed:9434739, RESID:AA0263, UniMod:425#Y] +comment: From DeltaMass: Average Mass: 32 +synonym: "(S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA)" EXACT DeltaMass-label [] +synonym: "35Hy2Tyr" EXACT PSI-MOD-label [] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "L-3',4',5'-trihydroxyphenylalanine" EXACT RESID-name [] +synonym: "L-3,4,5-TOPA" EXACT RESID-alternate [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 9 H 9 N 1 O 4" +xref: MassAvg: "195.17" +xref: MassMono: "195.053158" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:00707 ! hydroxylated tyrosine + +[Term] +id: MOD:00269 +name: O-(sn-1-glycerophosphoryl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine." [PubMed:8645220, RESID:AA0264, UniMod:419#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid" EXACT RESID-systematic [] +synonym: "alpha-glycerophosphoryl serine" EXACT RESID-alternate [] +synonym: "Glycerophospho" RELATED PSI-MS-label [] +synonym: "glycerophospho" RELATED UniMod-description [] +synonym: "glycerophosphoserine" EXACT RESID-alternate [] +synonym: "MOD_RES O-(sn-1-glycerophosphoryl)serine" EXACT UniProt-feature [] +synonym: "O-(sn-1-glycerophosphoryl)-L-serine" EXACT RESID-name [] +synonym: "O3-(sn-1-glycerophosphoryl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester" EXACT RESID-alternate [] +synonym: "O3-L-serine glyceryl-1-phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "154.06" +xref: DiffFormula: "C 3 H 7 N 0 O 5 P 1" +xref: DiffMono: "154.003110" +xref: Formula: "C 6 H 12 N 1 O 7 P 1" +xref: MassAvg: "241.14" +xref: MassMono: "241.035138" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00270 +name: 1-thioglycine (internal) +def: "A protein modification that effectively converts a glycine residue to an internal 1-thioglycine." [PubMed:11463785, PubMed:9367957, RESID:AA0265#INT] +comment: This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid). +subset: PSI-MOD-slim +synonym: "1-thioglycine" EXACT RESID-name [] +synonym: "2-amino-1-sulfanylethanone" EXACT RESID-alternate [] +synonym: "aminoethanethioic acid" EXACT RESID-systematic [] +synonym: "aminoethanethioic O-acid" EXACT RESID-alternate [] +synonym: "aminoethanethionic acid" EXACT RESID-alternate [] +synonym: "aminothioacetic acid" EXACT RESID-alternate [] +synonym: "Carboxy->Thiocarboxy" RELATED PSI-MS-label [] +synonym: "MOD_RES 1-thioglycine" EXACT UniProt-feature [] +synonym: "S(O)Gly" EXACT PSI-MOD-label [] +synonym: "thiocarboxylic acid" RELATED UniMod-description [] +xref: DiffAvg: "16.06" +xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1" +xref: DiffMono: "15.977156" +xref: Formula: "C 2 H 3 N 1 S 1" +xref: MassAvg: "73.11" +xref: MassMono: "72.998620" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01625 ! 1-thioglycine + +[Term] +id: MOD:00271 +name: heme P460-bis-L-cysteine-L-tyrosine +def: "A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:8325841, PubMed:9095195, RESID:AA0266] +comment: Cross-link 3. +synonym: "(10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature [] +synonym: "bis(S-cysteinyl)-(tyros-3'-yl)-heme" EXACT RESID-alternate [] +synonym: "heme P460-bis-L-cysteine-L-tyrosine" EXACT RESID-name [] +xref: DiffAvg: "614.48" +xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4 S 0" +xref: DiffMono: "614.161643" +xref: Formula: "C 49 Fe 1 H 49 N 7 O 8 S 2" +xref: MassAvg: "983.94" +xref: MassMono: "983.243341" +xref: Origin: "C, C, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00272 +name: O-(phospho-5'-adenosine)-L-threonine +def: "A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine." [PubMed:2989287, PubMed:8917428, RESID:AA0267, UniMod:405#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid" EXACT RESID-systematic [] +synonym: "5'-adenylic-O3-L-threonine" EXACT RESID-alternate [] +synonym: "ACT_SITE O-AMP-threonine intermediate" EXACT UniProt-feature [] +synonym: "AMP binding site" RELATED UniMod-description [] +synonym: "beta-5'-adenylic-L-threonine" EXACT RESID-alternate [] +synonym: "L-threonine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] +synonym: "MOD_RES O-AMP-threonine" EXACT UniProt-feature [] +synonym: "O(gamma)-5'-adenylic-L-threonine" EXACT RESID-alternate [] +synonym: "O-(phospho-5'-adenosine)-L-threonine" EXACT RESID-name [] +synonym: "O3-(phospho-5'-adenosine)-L-threonine" EXACT RESID-alternate [] +synonym: "O3-L-threonine 5'-adenosine phosphodiester" EXACT RESID-alternate [] +synonym: "Phosphoadenosine" RELATED PSI-MS-label [] +xref: DiffAvg: "329.21" +xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" +xref: DiffMono: "329.052520" +xref: Formula: "C 14 H 19 N 6 O 8 P 1" +xref: MassAvg: "430.31" +xref: MassMono: "430.100198" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01165 ! adenylated residue + +[Term] +id: MOD:00273 +name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide +def: "A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide." [PubMed:12764602, RESID:AA0268] +comment: Cross-link 7; secondary to RESID:AA0269. +synonym: "4Fe-2S-3O cluster" EXACT RESID-alternate [] +synonym: "hybrid four iron cluster 2" EXACT RESID-alternate [] +synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S)" EXACT UniProt-feature [] +synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group" EXACT UniProt-feature [] +synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen" EXACT UniProt-feature [] +synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic [] +synonym: "prismane iron-sulfur cofactor" RELATED RESID-misnomer [] +synonym: "tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide" EXACT RESID-name [] +xref: DiffAvg: "360.50" +xref: DiffFormula: "C 0 Fe 4 H -7 N 0 O 3 S 3" +xref: DiffMono: "360.585932" +xref: Formula: "C 28 Fe 4 H 34 N 9 O 14 S 7" +xref: MassAvg: "1168.43" +xref: MassMono: "1167.766769" +xref: Origin: "C, C, C, C, E, E, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00274 +name: L-cysteine persulfide +def: "A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide." [ChEBI:28839, PubMed:15096637, PubMed:4276457, PubMed:8161529, RESID:AA0269, UniMod:421] +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-disulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-disulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-hydrodisulfidopropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-hydropersulfidopropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-persulfhydrylpropanoic acid" EXACT RESID-alternate [] +synonym: "3-(thiosulfeno)-alanine" EXACT RESID-alternate [] +synonym: "3-disulfanylalanine" EXACT RESID-alternate [] +synonym: "ACT_SITE Cysteine persulfide intermediate" EXACT UniProt-feature [] +synonym: "L-cysteine persulfide" EXACT RESID-name [] +synonym: "MOD_RES Cysteine persulfide" EXACT UniProt-feature [] +synonym: "persulfide" RELATED UniMod-description [] +synonym: "S-mercaptocysteine" EXACT RESID-alternate [] +synonym: "S-sulfanylcysteine" EXACT RESID-alternate [] +synonym: "Sulfide" RELATED PSI-MS-label [] +synonym: "thiocysteine" EXACT RESID-alternate [] +xref: DiffAvg: "32.06" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S 1" +xref: DiffMono: "31.972071" +xref: Formula: "C 3 H 5 N 1 O 1 S 2" +xref: MassAvg: "135.20" +xref: MassMono: "134.981256" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01886 ! thiolated residue + +[Term] +id: MOD:00275 +name: 3'-(1'-L-histidyl)-L-tyrosine +def: "A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine." [ChEBI:19837, PubMed:10338009, RESID:AA0270] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] +synonym: "3'-(1'-L-histidyl)-L-tyrosine" EXACT RESID-name [] +synonym: "3'-(N(epsilon)-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "3'-(N1'-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "3'-(tau-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "3'-(tele-histidyl)tyrosine" EXACT RESID-alternate [] +synonym: "CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 15 H 14 N 4 O 3" +xref: MassAvg: "298.30" +xref: MassMono: "298.106590" +xref: Origin: "H, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00276 +name: heme P460-bis-L-cysteine-L-lysine +def: "A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12709052, PubMed:9237682, RESID:AA0271] +comment: Cross-link 3. +synonym: "(19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature [] +synonym: "bis(S-cysteinyl)-N6-lysino-heme" EXACT RESID-alternate [] +synonym: "heme P460-bis-L-cysteine-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "614.48" +xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4 S 0" +xref: DiffMono: "614.161643" +xref: Formula: "C 46 Fe 1 H 52 N 8 O 7 S 2" +xref: MassAvg: "948.94" +xref: MassMono: "948.274976" +xref: Origin: "C, C, K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00277 +name: 5-methyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine." [PubMed:10660523, PubMed:11875433, PubMed:9367957, RESID:AA0272] +synonym: "(2S,5S)-2-amino-5-carbamimidamidohexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-5-guanidinohexanoic acid" EXACT RESID-alternate [] +synonym: "4-methylarginine" RELATED RESID-misnomer [] +synonym: "5-methyl-L-arginine" EXACT RESID-name [] +synonym: "5-methylated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "C5Me1Arg" EXACT PSI-MOD-label [] +synonym: "delta-methylarginine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES 5-methylarginine" EXACT UniProt-feature [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 14 N 4 O 1" +xref: MassAvg: "170.22" +xref: MassMono: "170.116761" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00414 ! monomethylated L-arginine +is_a: MOD:00656 ! C-methylated residue + +[Term] +id: MOD:00278 +name: 2-methyl-L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine." [PubMed:10660523, PubMed:11875433, PubMed:9367957, RESID:AA0273] +synonym: "(S)-2-amino-2-methylpentanediamic acid" EXACT RESID-systematic [] +synonym: "2-methyl-L-glutamine" EXACT RESID-name [] +synonym: "2-methylated L-glutamine" EXACT PSI-MOD-alternate [] +synonym: "2-methylglutamine" EXACT RESID-alternate [] +synonym: "alpha-methylglutamine" EXACT RESID-alternate [] +synonym: "C2MeGln" EXACT PSI-MOD-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES 2-methylglutamine" EXACT UniProt-feature [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 10 N 2 O 2" +xref: MassAvg: "142.16" +xref: MassMono: "142.074228" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00656 ! C-methylated residue +is_a: MOD:00722 ! monomethylated L-glutamine + +[Term] +id: MOD:00279 +name: N-pyruvic acid 2-iminyl-L-cysteine +def: "A protein modification that effectively converts an Lcysteline residue to N-pyruvic acid 2-iminyl-L-cysteine." [PubMed:1388164, RESID:AA0274, UniMod:422#C] +subset: PSI-MOD-slim +synonym: "(R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N-pyruvate 2-iminyl-cysteine" EXACT UniProt-feature [] +synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] +synonym: "N-pyruvic acid 2-iminyl-L-cysteine" EXACT RESID-name [] +synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] +xref: DiffAvg: "70.05" +xref: DiffFormula: "C 3 H 2 N 0 O 2 S 0" +xref: DiffMono: "70.005479" +xref: Formula: "C 6 H 8 N 1 O 3 S 1" +xref: MassAvg: "174.19" +xref: MassMono: "174.022489" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01170 ! pyruvic acid iminylated residue + +[Term] +id: MOD:00280 +name: N-pyruvic acid 2-iminyl-L-valine +def: "A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine." [PubMed:2071591, RESID:AA0275, UniMod:422#V] +subset: PSI-MOD-slim +synonym: "(S)-2-(1-carboxy-2-methylpropanimino)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N-pyruvate 2-iminyl-valine" EXACT UniProt-feature [] +synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] +synonym: "N-pyruvic acid 2-iminyl-L-valine" EXACT RESID-name [] +synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] +xref: DiffAvg: "70.05" +xref: DiffFormula: "C 3 H 2 N 0 O 2" +xref: DiffMono: "70.005479" +xref: Formula: "C 8 H 12 N 1 O 3" +xref: MassAvg: "170.19" +xref: MassMono: "170.081718" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01170 ! pyruvic acid iminylated residue + +[Term] +id: MOD:00281 +name: 3'-heme-L-histidine +def: "A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12119398, PubMed:12429096, PubMed:12486054, PubMed:9712585, RESID:AA0276] +synonym: "2-[1-(N3'-histidyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] +synonym: "3'-heme-L-histidine" EXACT RESID-name [] +synonym: "[7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "BINDING Heme (covalent; via pros nitrogen)" EXACT UniProt-feature [] +synonym: "N(delta)-histidyl heme" EXACT RESID-alternate [] +synonym: "N(pi)-histidyl heme" EXACT RESID-alternate [] +synonym: "N3'-histidyl heme" EXACT RESID-alternate [] +synonym: "pros-histidyl heme" EXACT RESID-alternate [] +xref: DiffAvg: "616.50" +xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4" +xref: DiffMono: "616.177293" +xref: Formula: "C 40 Fe 1 H 39 N 7 O 5" +xref: MassAvg: "753.64" +xref: MassMono: "753.236205" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00282 +name: S-selenyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine." [PubMed:10430865, PubMed:10966817, PubMed:11827487, PubMed:12716131, PubMed:14594807, RESID:AA0277, UniMod:423#C] +synonym: "(R)-2-amino-3-(selanylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-hydroselenosulfidopropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-hydroselenylsulfidopropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-hydroselenylthiopropanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE S-selanylcysteine intermediate" EXACT UniProt-feature [] +synonym: "cysteine perselenide" RELATED RESID-misnomer [] +synonym: "Delta:Se(1)" RELATED PSI-MS-label [] +synonym: "MOD_RES S-selanylcysteine" EXACT UniProt-feature [] +synonym: "S-selanyl-L-cysteine" EXACT RESID-name [] +synonym: "S-selanylcysteine" EXACT RESID-alternate [] +synonym: "S-selenylcysteine" EXACT RESID-alternate [] +synonym: "selenyl" RELATED UniMod-description [] +xref: DiffAvg: "78.97" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0 Se 1" +xref: DiffMono: "79.916521" +xref: Formula: "C 3 H 5 N 1 O 1 S 1 Se 1" +xref: MassAvg: "182.11" +xref: MassMono: "182.925706" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00745 ! selenium containing residue +is_a: MOD:00778 ! residues isobaric at 182.9-183.0 Da +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00283 +name: N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine." [PubMed:10550045, PubMed:11349130, RESID:AA0278] +synonym: "(alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)]" EXACT RESID-systematic [] +synonym: "lysine derivative Lys(x)" EXACT RESID-alternate [] +synonym: "MOD_RES N6-poly(methylaminopropyl)lysine" EXACT UniProt-feature [] +synonym: "N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine" EXACT RESID-alternate [] +synonym: "N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine" EXACT RESID-name [] +synonym: "silaffin polycationic lysine derivative" EXACT RESID-alternate [] +xref: DiffAvg: "426.74" +xref: DiffFormula: "C 24 H 54 N 6 O 0" +xref: DiffMono: "426.440996" +xref: Formula: "C 30 H 66 N 8 O 1" +xref: MassAvg: "554.91" +xref: MassMono: "554.535959" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00284 +name: dihydroxyheme-L-aspartate ester-L-glutamate ester +def: "A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:10447690, RESID:AA0279] +comment: Cross-link 2. +synonym: "1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester" EXACT RESID-alternate [] +synonym: "[13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "BINDING Heme (covalent; via 2 links)" EXACT UniProt-feature [] +synonym: "dihydroxyheme-L-aspartate ester-L-glutamate ester" EXACT RESID-name [] +synonym: "peroxidase heme cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "612.47" +xref: DiffFormula: "C 34 Fe 1 H 28 N 4 O 4" +xref: DiffMono: "612.145993" +xref: Formula: "C 43 Fe 1 H 40 N 6 O 10" +xref: MassAvg: "856.67" +xref: MassMono: "856.215529" +xref: Origin: "D, E" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00285 +name: dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium +def: "A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:10447690, PubMed:10480885, PubMed:1320128, PubMed:7840679, RESID:AA0280] +comment: Cross-link 3. +synonym: "1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium" EXACT RESID-alternate [] +synonym: "[13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature [] +synonym: "dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium" EXACT RESID-name [] +synonym: "myeloperoxidase heme cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "613.47" +xref: DiffFormula: "C 34 Fe 1 H 29 N 4 O 4 S 0" +xref: DiffMono: "613.153269" +xref: FormalCharge: "1+" +xref: Formula: "C 48 Fe 1 H 50 N 7 O 11 S 1" +xref: MassAvg: "988.87" +xref: MassMono: "988.263290" +xref: Origin: "D, E, M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00286 +name: L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0281, UniMod:424#C] +synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] +synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum" EXACT RESID-systematic [] +synonym: "L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] +synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] +synonym: "MolybdopterinGD" RELATED PSI-MS-label [] +xref: DiffAvg: "1572.02" +xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4" +xref: DiffMono: "1572.985775" +xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 5" +xref: MassAvg: "1675.15" +xref: MassMono: "1675.994960" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01167 ! molybdopterin guanine dinucleotide + +[Term] +id: MOD:00287 +name: (2S,3R,4S)-3,4-dihydroxyproline +def: "A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline." [DeltaMass:0, PubMed:12686488, RESID:AA0282, UniMod:425#P] +comment: From DeltaMass: Average Mass: 32. +synonym: "(2S,3R,4S)-3,4-dihydroxyproline" EXACT RESID-name [] +synonym: "(2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "2,3-trans-3,4-cis-3,4-dihydroxy-L-proline" EXACT RESID-alternate [] +synonym: "2-alpha-3-beta-4-beta-3,4-dihydroxyproline" EXACT RESID-alternate [] +synonym: "3,4-dihydroxylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "3,4-Dihydroxylation (of Proline)" EXACT DeltaMass-label [] +synonym: "34Hy2Pro" EXACT PSI-MOD-label [] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "MOD_RES (3R,4S)-3,4-dihydroxyproline" EXACT UniProt-feature [] +synonym: "trans-2,3-cis-3,4-dihydroxy-L-proline" EXACT RESID-alternate [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00866 ! dihydroxylated proline + +[Term] +id: MOD:00288 +name: pyrroloquinoline quinone +def: "A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone." [ChEBI:18315, PubMed:1310505, PubMed:7665488, RESID:AA0283] +comment: Cross-link 2. +synonym: "2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone" EXACT RESID-alternate [] +synonym: "2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione" EXACT RESID-alternate [] +synonym: "4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid" EXACT RESID-systematic [] +synonym: "coenzyme PQQ" EXACT RESID-alternate [] +synonym: "CROSSLNK Pyrroloquinoline quinone (Glu-Tyr)" EXACT UniProt-feature [] +synonym: "methoxatin" EXACT RESID-alternate [] +synonym: "pyrroloquinoline quinone" EXACT RESID-name [] +xref: DiffAvg: "37.92" +xref: DiffFormula: "C 0 H -10 N 0 O 3" +xref: DiffMono: "37.906494" +xref: Formula: "C 14 H 6 N 2 O 8" +xref: MassAvg: "330.21" +xref: MassMono: "330.012415" +xref: Origin: "E, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00289 +name: tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide." [PubMed:9836629, RESID:AA0284] +comment: Cross-link 4. +synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (4Fe-4S); via tele nitrogen" EXACT UniProt-feature [] +synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron)" EXACT RESID-systematic [] +synonym: "tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide" EXACT RESID-name [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.597831" +xref: FormalCharge: "2-" +xref: Formula: "C 15 Fe 4 H 18 N 6 O 4 S 7" +xref: MassAvg: "794.15" +xref: MassMono: "793.684297" +xref: Origin: "C, C, C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00290 +name: tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide." [PubMed:7854413, RESID:AA0285] +comment: Cross-link 4. +synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (4Fe-4S); via pros nitrogen" EXACT UniProt-feature [] +synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron)" EXACT RESID-systematic [] +synonym: "tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide" EXACT RESID-name [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.597831" +xref: FormalCharge: "2-" +xref: Formula: "C 15 Fe 4 H 18 N 6 O 4 S 7" +xref: MassAvg: "794.15" +xref: MassMono: "793.684297" +xref: Origin: "C, C, C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00291 +name: tris-L-cysteinyl L-aspartato tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide." [PubMed:7819255, PubMed:9283079, RESID:AA0286] +comment: Cross-link 4. +synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] +synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron)" EXACT RESID-systematic [] +synonym: "tris-L-cysteinyl L-aspartato tetrairon tetrasulfide" EXACT RESID-name [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.597831" +xref: FormalCharge: "2-" +xref: Formula: "C 13 Fe 4 H 16 N 4 O 6 S 7" +xref: MassAvg: "772.09" +xref: MassMono: "771.652328" +xref: Origin: "C, C, C, D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00292 +name: N6-pyruvic acid 2-iminyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine." [PubMed:1463470, PubMed:7853400, PubMed:9047371, RESID:AA0287, UniMod:422#K] +synonym: "(2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE Schiff-base intermediate with substrate" EXACT UniProt-feature [] +synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] +synonym: "N6-pyruvic acid 2-iminyl-L-lysine" EXACT RESID-name [] +synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] +xref: DiffAvg: "70.05" +xref: DiffFormula: "C 3 H 2 N 0 O 2" +xref: DiffMono: "70.005479" +xref: Formula: "C 9 H 14 N 2 O 3" +xref: MassAvg: "198.22" +xref: MassMono: "198.100442" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01170 ! pyruvic acid iminylated residue + +[Term] +id: MOD:00293 +name: tris-L-cysteinyl L-serinyl tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide." [RESID:AA0288] +comment: Cross-link 4. +synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron)" EXACT RESID-systematic [] +synonym: "tris-L-cysteinyl L-serinyl tetrairon tetrasulfide" EXACT RESID-name [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.597831" +xref: FormalCharge: "2-" +xref: Formula: "C 12 Fe 4 H 16 N 4 O 5 S 7" +xref: MassAvg: "744.08" +xref: MassMono: "743.657414" +xref: Origin: "C, C, C, S" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00294 +name: bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide +def: "A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide." [RESID:AA0289] +comment: Cross-link 4. +synonym: "bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide" EXACT RESID-name [] +synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (4Fe-4S); via pros nitrogen" EXACT UniProt-feature [] +synonym: "tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron)" EXACT RESID-systematic [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.597831" +xref: FormalCharge: "2-" +xref: Formula: "C 15 Fe 4 H 18 N 6 O 5 S 6" +xref: MassAvg: "778.09" +xref: MassMono: "777.707141" +xref: Origin: "C, C, H, S" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00295 +name: O-octanoyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine." [PubMed:10604470, PubMed:12716131, RESID:AA0290, UniMod:426#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(octanoyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "L-serine octanoate ester" EXACT RESID-alternate [] +synonym: "LIPID O-octanoyl serine" EXACT UniProt-feature [] +synonym: "O-octanoyl-L-serine" EXACT RESID-name [] +synonym: "O-octanoylated L-serine" EXACT PSI-MOD-alternate [] +synonym: "O3-octanoyl-L-serine" EXACT RESID-alternate [] +synonym: "Octanoyl" RELATED PSI-MS-label [] +synonym: "octanoyl" RELATED UniMod-description [] +synonym: "OOctSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "126.20" +xref: DiffFormula: "C 8 H 14 N 0 O 1" +xref: DiffMono: "126.104465" +xref: Formula: "C 11 H 19 N 1 O 3" +xref: MassAvg: "213.28" +xref: MassMono: "213.136493" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00669 ! O-octanoylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00296 +name: O-D-glucuronosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine." [PubMed:10858503, PubMed:12716131, PubMed:7398618, RESID:AA0291, UniMod:54#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (GlcA)" EXACT UniProt-feature [] +synonym: "Glucuronyl" RELATED PSI-MS-label [] +synonym: "N-glucuronylation" RELATED UniMod-description [] +synonym: "O-D-glucuronosyl-L-serine" EXACT RESID-name [] +synonym: "O3-D-glucuronosyl-L-serine" EXACT RESID-alternate [] +xref: DiffAvg: "176.12" +xref: DiffFormula: "C 6 H 8 N 0 O 6" +xref: DiffMono: "176.032088" +xref: Formula: "C 9 H 13 N 1 O 8" +xref: MassAvg: "263.20" +xref: MassMono: "263.064116" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00447 ! N-glucuronylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00297 +name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide +def: "A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] +comment: Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate [] +synonym: "hybrid nickel-triiron cluster" EXACT RESID-alternate [] +synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic [] +synonym: "Ni-3Fe-2S-3O cluster" EXACT RESID-alternate [] +synonym: "tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide" EXACT RESID-name [] +xref: DiffAvg: "363.35" +xref: DiffFormula: "C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3" +xref: DiffMono: "362.586337" +xref: Formula: "C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7" +xref: MassAvg: "1171.28" +xref: MassMono: "1169.767174" +xref: Origin: "C, C, C, C, E, E, H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00741 ! nickel containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00298 +name: tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide +def: "A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [PubMed:2550436, RESID:AA0293] +comment: Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate [] +synonym: "hybrid nickel-triiron cluster" EXACT RESID-alternate [] +synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic [] +synonym: "Ni-3Fe-2S-3O cluster" EXACT RESID-alternate [] +synonym: "tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide" EXACT RESID-name [] +xref: DiffAvg: "363.35" +xref: DiffFormula: "C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3" +xref: DiffMono: "362.586337" +xref: Formula: "C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7" +xref: MassAvg: "1129.24" +xref: MassMono: "1127.756609" +xref: Origin: "C, C, C, C, E, H, S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00741 ! nickel containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00299 +name: N6-(L-isoaspartyl)-L-lysine (Asn) +def: "A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia." [ChEBI:21862, DeltaMass:0, PubMed:11000116, PubMed:6503713, RESID:AA0294] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature [] +synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate [] +synonym: "N-(beta-Aspartyl)-Lysine (Crosslink)" EXACT DeltaMass-label [] +synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name [] +synonym: "XLNK-4Asp-N6Lys(Asn)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 10 H 15 N 3 O 3" +xref: MassAvg: "225.25" +xref: MassMono: "225.111341" +xref: Origin: "K, N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia +is_a: MOD:01929 ! N6-(L-isoaspartyl)-L-lysine + +[Term] +id: MOD:00300 +name: L-glutamyl-5-poly(ADP-ribose) +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose)." [DeltaMass:0, PubMed:11246023, PubMed:15842200, PubMed:8533153, RESID:AA0295, UniMod:213#E] +synonym: "(S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "ADP Ribose addition" RELATED UniMod-description [] +synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] +synonym: "L-glutamyl-5-poly(ADP-ribose)" EXACT RESID-name [] +synonym: "L-isoglutamyl-poly(ADP-ribose)" EXACT RESID-alternate [] +synonym: "MOD_RES PolyADP-ribosyl glutamic acid" EXACT UniProt-feature [] +synonym: "O-ADP-ribosylation (on Glutamate or C terminus)" EXACT DeltaMass-label [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 20 H 28 N 6 O 16 P 2" +xref: MassAvg: "670.42" +xref: MassMono: "670.103702" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00301 +name: O-(N-acetylglucosamine-1-phosphoryl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine." [DeltaMass:0, PubMed:6438439, PubMed:6993483, PubMed:8631906, RESID:AA0296, UniMod:428] +synonym: "(2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid" EXACT RESID-systematic [] +synonym: "N-acetylglucosamine-1-phosphoryl" RELATED UniMod-description [] +synonym: "O-(N-acetylglucosamine-1-phosphoryl)-L-serine" EXACT RESID-name [] +synonym: "O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine" EXACT RESID-alternate [] +synonym: "O-GlcNAc-1-phosphorylation (of Serine)" EXACT DeltaMass-label [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester" EXACT RESID-alternate [] +synonym: "PhosphoHexNAc" RELATED PSI-MS-label [] +xref: DiffAvg: "283.17" +xref: DiffFormula: "C 8 H 14 N 1 O 8 P 1" +xref: DiffMono: "283.045703" +xref: Formula: "C 11 H 19 N 2 O 10 P 1" +xref: MassAvg: "370.25" +xref: MassMono: "370.077731" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01804 ! glycosylphosphorylated residue + +[Term] +id: MOD:00302 +name: O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine." [PubMed:10037765, PubMed:15649890, RESID:AA0297, UniMod:429] +synonym: "O-(alpha-D-mannosyl-1-phosphoryl)-L-serine" EXACT RESID-alternate [] +synonym: "O-(D-mannose-1-phosphoryl)-L-serine" EXACT RESID-name [] +synonym: "O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine" EXACT RESID-systematic [] +synonym: "O3-(D-mannose-1-phosphoryl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-L-serine alpha-D-mannopyranose 1-phosphodiester" EXACT RESID-alternate [] +synonym: "phosphoglycosyl-D-mannose-1-phosphoryl" RELATED UniMod-description [] +synonym: "PhosphoHex" RELATED PSI-MS-label [] +xref: DiffAvg: "242.12" +xref: DiffFormula: "C 6 H 11 N 0 O 8 P 1" +xref: DiffMono: "242.019154" +xref: Formula: "C 9 H 16 N 1 O 10 P 1" +xref: MassAvg: "329.20" +xref: MassMono: "329.051182" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01804 ! glycosylphosphorylated residue + +[Term] +id: MOD:00303 +name: heptakis-L-histidino tetracopper mu4-sulfide hydroxide +def: "A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [PubMed:11024061, PubMed:11041839, RESID:AA0298] +comment: Cross-link 7. +synonym: "heptakis-L-histidino tetracopper mu4-sulfide hydroxide" EXACT RESID-name [] +synonym: "mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper)" EXACT RESID-systematic [] +synonym: "nitrous oxide reductase nosZ CuZ cluster" EXACT RESID-alternate [] +synonym: "pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide" EXACT RESID-alternate [] +xref: DiffAvg: "296.19" +xref: DiffFormula: "C 0 Cu 4 H -6 N 0 O 1 S 1" +xref: DiffMono: "293.638425" +xref: Formula: "C 42 Cu 4 H 43 N 21 O 8 S 1" +xref: MassAvg: "1256.19" +xref: MassMono: "1253.050808" +xref: Origin: "H, H, H, H, H, H, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00742 ! copper containing modified residue +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00304 +name: L-leucine methyl ester +def: "A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester." [PubMed:10191253, PubMed:11875433, PubMed:8206937, RESID:AA0299, UniMod:34#C-term] +comment: incidental to RESID:AA0039 +subset: PSI-MOD-slim +synonym: "2-amino-4-methylpentanoic methyl ester" EXACT RESID-alternate [] +synonym: "alpha-aminoisocaproic methyl ester" EXACT RESID-alternate [] +synonym: "L-leucine methyl ester" EXACT RESID-name [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methyl (2S)-2-amino-4-methylpentanoate" EXACT RESID-systematic [] +synonym: "methyl esterified L-leucine" EXACT PSI-MOD-alternate [] +synonym: "methyl L-leucinate" EXACT RESID-alternate [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES Leucine methyl ester" EXACT UniProt-feature [] +synonym: "OMeLeu" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 14 N 1 O 2" +xref: MassAvg: "144.19" +xref: MassMono: "144.102454" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00662 ! methylated leucine +is_a: MOD:01689 ! alpha-carboxyl methylated residue + +[Term] +id: MOD:00305 +name: hexakis-L-cysteinyl L-serinyl octairon heptasulfide +def: "A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide." [PubMed:10525412, PubMed:12215645, PubMed:9063865, RESID:AA0300] +comment: Cross-link 7; incidental to RESID:AA0141. +synonym: "Cys6Ser-[8Fe7S]" EXACT PSI-MOD-label [] +synonym: "hexakis-L-cysteinyl L-serinyl octairon heptasulfide" EXACT RESID-name [] +synonym: "METAL Iron-sulfur (8Fe-7S)" EXACT UniProt-feature [] +synonym: "nitrogenase P-cluster" EXACT RESID-alternate [] +xref: DiffAvg: "663.12" +xref: DiffFormula: "C 0 Fe 8 H -8 N 0 O 0 S 7" +xref: DiffMono: "663.223042" +xref: FormalCharge: "3-" +xref: Formula: "C 21 Fe 8 H 27 N 7 O 8 S 13" +xref: MassAvg: "1369.03" +xref: MassMono: "1368.310179" +xref: Origin: "C, C, C, C, C, C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00306 +name: residues isobaric at 113.084064 Da +def: "Natural or modified residues with a mass of 113.084064 Da." [PubMed:10523135, RESID:AA0301] +subset: PSI-MOD-slim +synonym: "L-isoleucine or L-leucine" EXACT RESID-name [] +synonym: "Xle" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da +is_a: MOD:00624 ! residues isobaric at 113.0-113.1 Da + +[Term] +id: MOD:00307 +name: L-aspartimide +def: "A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide." [DeltaMass:18, PubMed:12771378, PubMed:2378679, PubMed:7662664, PubMed:7988548, PubMed:9309583, RESID:AA0302, UniMod:23#N] +comment: From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956. +synonym: "(3S)-3-amino-2,5-pyrrolidinedione" EXACT RESID-systematic [] +synonym: "2-amino-butanimide" EXACT RESID-alternate [] +synonym: "alpha-aminosuccinimide" EXACT RESID-alternate [] +synonym: "ASI" EXACT RESID-alternate [] +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +synonym: "L-2-aminosuccinimide" EXACT RESID-alternate [] +synonym: "L-3-aminosuccinimide" RELATED RESID-misnomer [] +synonym: "L-asparaginimide" EXACT RESID-alternate [] +synonym: "L-aspartimide" EXACT RESID-name [] +synonym: "Succinimide formation from asparagine" EXACT DeltaMass-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 4 H 5 N 2 O 2" +xref: MassAvg: "113.10" +xref: MassMono: "113.035102" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00704 ! dehydrated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00308 +name: L-glutamimide +def: "A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide." [PubMed:12771378, PubMed:14593103, RESID:AA0303, UniMod:23#Q] +synonym: "(3S)-3-aminopiperidine-2,6-dione" EXACT RESID-systematic [] +synonym: "2-aminopentanimide" EXACT RESID-alternate [] +synonym: "3-amino-2,6-piperidinedione" EXACT RESID-alternate [] +synonym: "alpha-aminoglutarimide" EXACT RESID-alternate [] +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +synonym: "L-glutamimide" EXACT RESID-name [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 7 N 2 O 2" +xref: MassAvg: "127.12" +xref: MassMono: "127.050752" +xref: Origin: "Q" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00704 ! dehydrated residue +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:00309 +name: L-beta-carboxyaspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid." [OMSSA:47, PubMed:6390094, PubMed:7138832, PubMed:7457858, PubMed:8135347, RESID:AA0304, UniMod:299#D] +comment: References to this modification as a gamma-carboxylation are in error [JSG]. +synonym: "(2S)-2-aminoethane-1,1,2-tricarboxylic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-carboxybutanedioic acid" EXACT RESID-alternate [] +synonym: "3-carboxy-L-aspartic acid" EXACT RESID-name [] +synonym: "3-carboxyaspartic acid" EXACT RESID-alternate [] +synonym: "3CbxAsp" EXACT PSI-MOD-label [] +synonym: "beta-carboxyaspartic acid" EXACT RESID-alternate [] +synonym: "Carboxy" RELATED PSI-MS-label [] +synonym: "Carboxy" RELATED UniMod-interim [] +synonym: "Carboxylation" RELATED UniMod-description [] +synonym: "gammacarboxyld" EXACT OMSSA-label [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "C 5 H 5 N 1 O 5" +xref: MassAvg: "159.10" +xref: MassMono: "159.016772" +xref: Origin: "D" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:00310 +name: N5-methyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine." [PubMed:11875433, PubMed:9792625, PubMed:9873020, RESID:AA0305] +synonym: "(2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid" EXACT RESID-systematic [] +synonym: "delta-N-methylarginine" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N5-methylarginine" EXACT UniProt-feature [] +synonym: "N5-carbamimidoyl-N5-methyl-L-ornithine" EXACT RESID-alternate [] +synonym: "N5-methyl-L-arginine" EXACT RESID-name [] +synonym: "N5-methylated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "N5Me1Arg" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 14 N 4 O 1" +xref: MassAvg: "170.22" +xref: MassMono: "170.116761" +xref: Origin: "R" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00414 ! monomethylated L-arginine +is_a: MOD:00602 ! N-methylated residue + +[Term] +id: MOD:00311 +name: L-cysteine coenzyme A disulfide +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide." [DeltaMass:0, PubMed:1734967, RESID:AA0306, UniMod:281#C] +comment: DeltaMass gives no formula with mass as 454. +synonym: "(2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate)" EXACT RESID-systematic [] +synonym: "coenzyme A L-cysteine mixed disulfide" EXACT RESID-alternate [] +synonym: "CoenzymeA" RELATED PSI-MS-label [] +synonym: "Cysteine modified Coenzyme A" RELATED UniMod-description [] +synonym: "L-cysteine coenzyme A disulfide" EXACT RESID-name [] +synonym: "SCoACys" EXACT PSI-MOD-label [] +xref: DiffAvg: "765.52" +xref: DiffFormula: "C 21 H 34 N 7 O 16 P 3 S 1" +xref: DiffMono: "765.099559" +xref: Formula: "C 24 H 39 N 8 O 17 P 3 S 2" +xref: MassAvg: "868.66" +xref: MassMono: "868.108744" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01862 ! disulfide conjugated residue + +[Term] +id: MOD:00312 +name: S-myristoyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine." [PubMed:10026218, PubMed:10080938, PubMed:8824274, RESID:AA0307, UniMod:45#C] +synonym: "(R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "LIPID S-myristoyl cysteine" EXACT UniProt-feature [] +synonym: "Myristoyl" RELATED PSI-MS-label [] +synonym: "Myristoylation" RELATED UniMod-description [] +synonym: "S-(C14:1 aliphatic acyl)cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-myristoyl-L-cysteine" EXACT RESID-name [] +synonym: "S-myristoylated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "SMyrCys" EXACT PSI-MOD-label [] +synonym: "tetradecanoate cysteine thioester" EXACT RESID-alternate [] +xref: DiffAvg: "210.36" +xref: DiffFormula: "C 14 H 26 N 0 O 1 S 0" +xref: DiffMono: "210.198365" +xref: Formula: "C 17 H 31 N 1 O 2 S 1" +xref: MassAvg: "313.50" +xref: MassMono: "313.207550" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00655 ! S-myristoylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00313 +name: S-palmitoleyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine." [OMSSA:187, PubMed:8294460, RESID:AA0308, UniMod:431#C] +synonym: "(R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "cis-9-hexadecenoate cysteine thioester" EXACT RESID-alternate [] +synonym: "mod187" EXACT OMSSA-label [] +synonym: "Palmitoleyl" RELATED PSI-MS-label [] +synonym: "palmitoleyl" RELATED UniMod-description [] +synonym: "S-palmitoleyl-L-cysteine" EXACT RESID-name [] +synonym: "S-palmitoleylated L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "SPamD1Cys" EXACT PSI-MOD-label [] +xref: DiffAvg: "236.40" +xref: DiffFormula: "C 16 H 28 N 0 O 1 S 0" +xref: DiffMono: "236.214016" +xref: Formula: "C 19 H 33 N 1 O 2 S 1" +xref: MassAvg: "339.54" +xref: MassMono: "339.223200" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00672 ! S-acylated residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01423 ! palmitoleylated residue + +[Term] +id: MOD:00314 +name: glycine cholesterol ester +def: "A protein modification that effectively converts a glycine residue to glycine cholesterol ester." [PubMed:11111088, PubMed:8824192, RESID:AA0309, UniMod:432#C-term] +comment: Incidental to RESID:AA0060. UniMod origin corrected [JSG]. +subset: PSI-MOD-slim +synonym: "C-cholesterol" RELATED UniMod-interim [] +synonym: "cholesterol ester" RELATED UniMod-description [] +synonym: "cholesteryl glycinate" EXACT RESID-alternate [] +synonym: "glycine cholest-5-en-3beta-ol ester" EXACT RESID-systematic [] +synonym: "glycine cholesterol ester" EXACT RESID-name [] +synonym: "hedgehog lipophilic adduct" EXACT RESID-alternate [] +synonym: "LIPID Cholesterol glycine ester" EXACT UniProt-feature [] +xref: DiffAvg: "368.65" +xref: DiffFormula: "C 27 H 44 N 0 O 0" +xref: DiffMono: "368.344301" +xref: Formula: "C 29 H 48 N 1 O 2" +xref: MassAvg: "442.71" +xref: MassMono: "442.368505" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00315 +name: pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide +def: "A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide." [PubMed:11509720, PubMed:2550436, RESID:AA0310] +comment: Cross-link 6. +synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate [] +synonym: "METAL Nickel-iron-sulfur (Ni-4Fe-5S)" EXACT UniProt-feature [] +synonym: "METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen" EXACT UniProt-feature [] +synonym: "mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron)" EXACT RESID-systematic [] +synonym: "Ni-4Fe-5S cluster" EXACT RESID-alternate [] +synonym: "pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide" EXACT RESID-name [] +xref: DiffAvg: "436.33" +xref: DiffFormula: "C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5" +xref: DiffMono: "435.488498" +xref: Formula: "C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10" +xref: MassAvg: "1089.16" +xref: MassMono: "1087.593333" +xref: Origin: "C, C, C, C, C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00741 ! nickel containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00316 +name: N4,N4-dimethyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine." [PubMed:12964758, PubMed:14570711, PubMed:8783012, RESID:AA0311, UniMod:36#N] +synonym: "(2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N4,N4-dimethylbutanediamic acid" EXACT RESID-alternate [] +synonym: "beta-dimethylasparagine" RELATED RESID-misnomer [] +synonym: "di-Methylation" RELATED UniMod-description [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "MOD_RES N4,N4-dimethylasparagine" EXACT UniProt-feature [] +synonym: "N(gamma),N(gamma)-dimethylasparagine" EXACT RESID-alternate [] +synonym: "N4,N4-dimethyl-L-asparagine" EXACT RESID-name [] +synonym: "N4,N4-dimethylated L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "N4Me2Asn" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 6 H 10 N 2 O 2" +xref: MassAvg: "142.16" +xref: MassMono: "142.074228" +xref: Origin: "N" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00429 ! dimethylated residue +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00673 ! methylated asparagine + +[Term] +id: MOD:00317 +name: N6-3,4-didehydroretinylidene-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine." [PubMed:10717661, PubMed:3257009, PubMed:4056688, RESID:AA0312, UniMod:433#K] +synonym: "(S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT RESID-systematic [] +synonym: "3,4-didehydroretinylidene" RELATED UniMod-description [] +synonym: "Didehydroretinylidene" RELATED PSI-MS-label [] +synonym: "N6-(3,4-didehydroretinylidene)-L-lysine" EXACT RESID-name [] +synonym: "N6-3-dehydroretinal-L-lysine" EXACT RESID-alternate [] +synonym: "N6-3-dehydroretinyl-lysine" EXACT RESID-alternate [] +xref: DiffAvg: "264.41" +xref: DiffFormula: "C 20 H 24 N 0 O 0" +xref: DiffMono: "264.187801" +xref: Formula: "C 26 H 36 N 2 O 1" +xref: MassAvg: "392.59" +xref: MassMono: "392.282764" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00318 +name: 4'-(S-L-cysteinyl)-L-tryptophyl quinone +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone." [PubMed:11555656, PubMed:11717396, RESID:AA0313] +comment: Cross-link 2; secondary to RESID:AA0148. +synonym: "(2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid" EXACT RESID-systematic [] +synonym: "3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione" EXACT RESID-alternate [] +synonym: "4'-(L-cystein-S-yl)-L-tryptophyl quinone" EXACT RESID-name [] +synonym: "4-(S-cysteinyl)tryptophan-6,7-dione" EXACT RESID-alternate [] +synonym: "CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp)" EXACT UniProt-feature [] +synonym: "CTQ" EXACT RESID-alternate [] +synonym: "cysteine tryptophylquinone" EXACT RESID-alternate [] +xref: DiffAvg: "27.97" +xref: DiffFormula: "C 0 H -4 N 0 O 2 S 0" +xref: DiffMono: "27.958529" +xref: Formula: "C 14 H 11 N 3 O 4 S 1" +xref: MassAvg: "317.32" +xref: MassMono: "317.047027" +xref: Origin: "C, W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00319 +name: 3-(S-L-cysteinyl)-L-aspartic acid +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid." [PubMed:11555656, PubMed:11717396, RESID:AA0314] +comment: Cross-link 2. +synonym: "(2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid" EXACT RESID-systematic [] +synonym: "(2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "3-(L-cystein-S-yl)-L-aspartic acid" EXACT RESID-name [] +synonym: "3-carboxy-L-lanthionine" EXACT RESID-alternate [] +synonym: "CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 7 H 8 N 2 O 4 S 1" +xref: MassAvg: "216.21" +xref: MassMono: "216.020478" +xref: Origin: "C, D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01993 ! beta-carbon thioether crosslinked residues + +[Term] +id: MOD:00320 +name: 4-(S-L-cysteinyl)-L-glutamic acid +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid." [ChEBI:20293, PubMed:11555656, PubMed:11717396, RESID:AA0315] +comment: Cross-link 2. +synonym: "(2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid" EXACT RESID-alternate [] +synonym: "(2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid" EXACT RESID-systematic [] +synonym: "4-(L-cystein-S-yl)-L-glutamic acid" EXACT RESID-name [] +synonym: "CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 8 H 10 N 2 O 4 S 1" +xref: MassAvg: "230.24" +xref: MassMono: "230.036128" +xref: Origin: "C, E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00321 +name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester +def: "A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester." [PubMed:11435437, PubMed:7949339, RESID:AA0316, UniMod:434#D] +synonym: "(7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid" EXACT RESID-systematic [] +synonym: "barley lipid transfer protein modification" EXACT RESID-alternate [] +synonym: "CHDH" RELATED PSI-MS-label [] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester" EXACT RESID-name [] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester" RELATED UniMod-description [] +synonym: "LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester" EXACT UniProt-feature [] +xref: DiffAvg: "294.39" +xref: DiffFormula: "C 17 H 26 N 0 O 4" +xref: DiffMono: "294.183109" +xref: Formula: "C 21 H 31 N 1 O 7" +xref: MassAvg: "409.48" +xref: MassMono: "409.210052" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00322 +name: 1'-methyl-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine." [PubMed:10601317, PubMed:11474090, PubMed:11875433, PubMed:6692818, PubMed:8076, PubMed:8645219, RESID:AA0317] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1'-methyl-L-histidine" EXACT RESID-name [] +synonym: "3-methylhistidine" RELATED RESID-misnomer [] +synonym: "4-methyl-histidine" RELATED RESID-misnomer [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES Tele-methylhistidine" EXACT UniProt-feature [] +synonym: "N(epsilon)-methylhistidine" EXACT RESID-alternate [] +synonym: "N(tau)-methylhistidine" EXACT RESID-alternate [] +synonym: "NteleMeHis" EXACT PSI-MOD-label [] +synonym: "tele-methylated L-histidine" EXACT PSI-MOD-alternate [] +synonym: "tele-methylhistidine" EXACT RESID-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 9 N 3 O 1" +xref: MassAvg: "151.17" +xref: MassMono: "151.074562" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00724 ! N-methylated L-histidine + +[Term] +id: MOD:00323 +name: L-lysine methyl ester +def: "A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester." [PubMed:10973948, PubMed:11875433, RESID:AA0318, UniMod:34#C-term] +subset: PSI-MOD-slim +synonym: "2,6-diaminohexanoic methyl ester" EXACT RESID-alternate [] +synonym: "alpha,epsilon-diaminocaproic methyl ester" EXACT RESID-alternate [] +synonym: "L-lysine methyl ester" EXACT RESID-name [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methyl (S)-2,6-diaminohexanoate" EXACT RESID-systematic [] +synonym: "methyl esterified L-lysine" EXACT PSI-MOD-alternate [] +synonym: "methyl L-lysinate" EXACT RESID-alternate [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES Lysine methyl ester" EXACT UniProt-feature [] +synonym: "OMeLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 15 N 2 O 2" +xref: MassAvg: "159.21" +xref: MassMono: "159.113353" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01683 ! monomethylated L-lysine +is_a: MOD:01689 ! alpha-carboxyl methylated residue + +[Term] +id: MOD:00324 +name: L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) +def: "A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:8658132, PubMed:8658134, RESID:AA0319] +synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] +synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide" EXACT RESID-systematic [] +synonym: "L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] +xref: DiffAvg: "1588.01" +xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 27 P 4 S 4" +xref: DiffMono: "1588.980690" +xref: Formula: "C 43 H 52 Mo 1 N 21 O 29 P 4 S 4" +xref: MassAvg: "1675.09" +xref: MassMono: "1676.012718" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00744 ! molybdenum pterin containing modification +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00325 +name: L-beta-methylthioasparagine +def: "A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine." [RESID:AA0320, UniMod:39#N] +comment: This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid" EXACT RESID-systematic [] +synonym: "2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "3-(methylthio)-L-asparagine" EXACT RESID-name [] +synonym: "3-carboxamido-S-methyl-cysteine" EXACT RESID-alternate [] +synonym: "beta-(methylthio)asparagine" EXACT RESID-alternate [] +synonym: "Beta-methylthiolation" RELATED UniMod-description [] +synonym: "Methylthio" RELATED UniMod-interim [] +xref: DiffAvg: "46.09" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" +xref: DiffMono: "45.987721" +xref: Formula: "C 5 H 8 N 2 O 2 S 1" +xref: MassAvg: "160.19" +xref: MassMono: "160.030649" +xref: Origin: "N" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01153 ! methylthiolated residue + +[Term] +id: MOD:00326 +name: L-pyrrolysine (Lys) +def: "A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process)." [PubMed:11435424, PubMed:12029131, PubMed:12029132, PubMed:15314242, PubMed:16096277, RESID:AA0321#LYS, UniMod:435#K] +comment: This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG]. +synonym: "(2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid" EXACT RESID-alternate [] +synonym: "L-pyrrolysine" EXACT RESID-name [] +synonym: "monomethylamine methyltransferase cofactor lysine adduct" EXACT RESID-alternate [] +synonym: "N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine" EXACT RESID-alternate [] +synonym: "NON_STD Pyrrolysine" EXACT UniProt-feature [] +synonym: "Pyl(Lys)" EXACT PSI-MOD-label [] +xref: DiffAvg: "109.13" +xref: DiffFormula: "C 6 H 7 N 1 O 1" +xref: DiffMono: "109.052764" +xref: Formula: "C 12 H 19 N 3 O 2" +xref: MassAvg: "237.30" +xref: MassMono: "237.147727" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01187 ! L-pyrrolysine residue + +[Term] +id: MOD:00327 +name: 3-hydroxy-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan." [PubMed:10024453, PubMed:11457355, RESID:AA0322] +synonym: "(2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "3-hydroxy-L-tryptophan" EXACT RESID-name [] +synonym: "3-hydroxylated L-tryptophan" EXACT PSI-MOD-alternate [] +synonym: "3-hydroxytryptophan" EXACT RESID-alternate [] +synonym: "3HyTrp" EXACT PSI-MOD-label [] +synonym: "beta-hydroxytryptophan" EXACT RESID-alternate [] +synonym: "MOD_RES 3-hydroxytryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 11 H 10 N 2 O 2" +xref: MassAvg: "202.21" +xref: MassMono: "202.074228" +xref: Origin: "W" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01622 ! monohydroxylated tryptophan + +[Term] +id: MOD:00328 +name: O4'-(phospho-3'-DNA)-L-tyrosine +def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine." [PubMed:2211714, RESID:AA0323] +synonym: "(S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate" EXACT UniProt-feature [] +synonym: "O4'-(phospho-3'-DNA)-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-L-tyrosine 3'-DNA phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 9 H 10 N 1 O 5 P 1" +xref: MassAvg: "243.15" +xref: MassMono: "243.029659" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00750 ! deoxyribonucleic acid linked residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00329 +name: hydroxyheme-L-glutamate ester +def: "A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:11139583, PubMed:11821421, PubMed:11980497, RESID:AA0324, UniMod:436#E] +synonym: "5-hydroxymethyl protoporphyrin IX 5-glutamate ester" EXACT RESID-alternate [] +synonym: "[3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "BINDING Heme (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "cytochrome P450 CYP4A family heme cofactor" EXACT RESID-alternate [] +synonym: "Hydroxyheme" RELATED PSI-MS-label [] +synonym: "hydroxyheme" RELATED UniMod-description [] +synonym: "hydroxyheme-L-glutamate ester" EXACT RESID-name [] +xref: DiffAvg: "614.48" +xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4" +xref: DiffMono: "614.161643" +xref: Formula: "C 39 Fe 1 H 37 N 5 O 7" +xref: MassAvg: "743.60" +xref: MassMono: "743.204236" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00330 +name: (phospho-5'-guanosine)-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine." [PubMed:10529169, PubMed:10869342, PubMed:7559521, RESID:AA0325, UniMod:413#H] +synonym: "(2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1'-(phospho-5'-guanosine)-L-histidine" EXACT RESID-name [] +synonym: "ACT_SITE GMP-histidine intermediate" EXACT UniProt-feature [] +synonym: "L-histidine 5'-guanosine phosphoramidester" EXACT RESID-alternate [] +synonym: "L-histidine monoanhydride with 5'-guanylic acid" EXACT RESID-alternate [] +synonym: "N(tau)-5'-guanylic-L-histidine" EXACT RESID-alternate [] +synonym: "N1'-guanylylated histidine" EXACT RESID-alternate [] +synonym: "phospho-guanosine" RELATED UniMod-description [] +synonym: "Phosphoguanosine" RELATED PSI-MS-label [] +synonym: "tele-5'-guanylic-L-histidine" EXACT RESID-alternate [] +xref: DiffAvg: "345.21" +xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1" +xref: DiffMono: "345.047434" +xref: Formula: "C 16 H 19 N 8 O 8 P 1" +xref: MassAvg: "482.35" +xref: MassMono: "482.106346" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01163 ! guanylated residue + +[Term] +id: MOD:00331 +name: tetrakis-L-cysteinyl triiron tetrasulfide +def: "A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide." [PubMed:11592901, PubMed:11941493, PubMed:2511202, PubMed:6094558, RESID:AA0326] +comment: Cross-link 4. +synonym: "bis[bis-L-cysteinyl iron disulfido]iron" EXACT RESID-alternate [] +synonym: "di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron)" EXACT RESID-systematic [] +synonym: "tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron" EXACT RESID-alternate [] +synonym: "tetrakis-L-cysteinyl linear [3Fe-4S] cluster" EXACT RESID-alternate [] +synonym: "tetrakis-L-cysteinyl triiron tetrasulfide" EXACT RESID-name [] +synonym: "tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster" EXACT RESID-alternate [] +xref: DiffAvg: "291.74" +xref: DiffFormula: "C 0 Fe 3 H -4 N 0 O 0 S 4" +xref: DiffMono: "291.663442" +xref: FormalCharge: "3-" +xref: Formula: "C 12 Fe 3 H 16 N 4 O 4 S 8" +xref: MassAvg: "704.30" +xref: MassMono: "703.700181" +xref: Origin: "C, C, C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00332 +name: omega-N-glucosyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine." [PubMed:15279557, PubMed:8521968, PubMed:9536051, RESID:AA0327, UniMod:41#R] +synonym: "(2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +synonym: "NG-beta-D-glucosylarginine" EXACT RESID-alternate [] +synonym: "omega-N-(beta-D-glucosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "omega-N-glucosyl-L-arginine" EXACT RESID-name [] +synonym: "omega-N-glycosyl-L-arginine" EXACT RESID-alternate [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 12 H 22 N 4 O 6" +xref: MassAvg: "318.33" +xref: MassMono: "318.153934" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00433 ! glucosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:01980 ! omega-N-glycosyl-L-arginine + +[Term] +id: MOD:00333 +name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine +def: "A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine." [PubMed:7559516, PubMed:7835418, PubMed:8183363, RESID:AA0328, UniMod:437#C-term] +comment: UniMod origin shown as C-term [JSG]. +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine" EXACT RESID-name [] +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine" RELATED UniMod-description [] +synonym: "5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine" EXACT RESID-systematic [] +synonym: "9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine" EXACT RESID-alternate [] +synonym: "C-Asn-deriv" RELATED UniMod-interim [] +synonym: "microcin C7 asparagine modification" EXACT RESID-alternate [] +synonym: "MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide" EXACT UniProt-feature [] +synonym: "N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide" EXACT RESID-alternate [] +xref: DiffAvg: "386.30" +xref: DiffFormula: "C 13 H 19 N 6 O 6 P 1" +xref: DiffMono: "386.110369" +xref: Formula: "C 17 H 26 N 8 O 9 P 1" +xref: MassAvg: "517.42" +xref: MassMono: "517.156036" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00334 +name: 1'-heme-L-histidine +def: "A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12033922, PubMed:12121092, RESID:AA0329, UniMod:390#H] +synonym: "(S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] +synonym: "1'-heme-L-histidine" EXACT RESID-name [] +synonym: "2-[1-(N1'-histidyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] +synonym: "BINDING Heme (covalent; via tele nitrogen)" EXACT UniProt-feature [] +synonym: "Heme" RELATED PSI-MS-label [] +synonym: "heme" RELATED UniMod-description [] +synonym: "N(epsilon)-histidyl heme" EXACT RESID-alternate [] +synonym: "N(tau)-histidyl heme" EXACT RESID-alternate [] +synonym: "N1'-histidyl heme" EXACT RESID-alternate [] +synonym: "tele-histidyl heme" EXACT RESID-alternate [] +xref: DiffAvg: "616.50" +xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4" +xref: DiffMono: "616.177293" +xref: Formula: "C 40 Fe 1 H 39 N 7 O 5" +xref: MassAvg: "753.64" +xref: MassMono: "753.236205" +xref: Origin: "H" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00699 ! porphyrin modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00335 +name: (2S,3S,2'R)-3-methyllanthionine sulfoxide +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide." [PubMed:7737178, PubMed:9219543, RESID:AA0330] +comment: Cross-link 2. +synonym: "(2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "(2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid" EXACT RESID-systematic [] +synonym: "3-methyl-L-lanthionine S-oxide" EXACT RESID-alternate [] +synonym: "3-methyl-L-lanthionine sulfoxide" EXACT RESID-name [] +synonym: "CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys)" EXACT UniProt-feature [] +synonym: "S-oxy-3-methyllanthionine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 7 H 10 N 2 O 3 S 1" +xref: MassAvg: "202.23" +xref: MassMono: "202.041213" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01993 ! beta-carbon thioether crosslinked residues +relationship: has_functional_parent MOD:01981 ! 3-methyllanthionine + +[Term] +id: MOD:00336 +name: tris-L-cysteinyl L-aspartato diiron disulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide." [PubMed:10968624, PubMed:1312028, PubMed:7947772, RESID:AA0331] +comment: Cross-link 4. +synonym: "di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron)" EXACT RESID-systematic [] +synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] +synonym: "tris-L-cysteinyl L-aspartato diiron disulfide" EXACT RESID-name [] +xref: DiffAvg: "171.78" +xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" +xref: DiffMono: "171.783814" +xref: FormalCharge: "2-" +xref: Formula: "C 13 Fe 2 H 16 N 4 O 6 S 5" +xref: MassAvg: "596.28" +xref: MassMono: "595.838311" +xref: Origin: "C, C, C, D" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00337 +name: S-carbamoyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine." [PubMed:12586941, PubMed:240389, RESID:AA0332, UniMod:5#C] +synonym: "(R)-2-amino-3-(carbamoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(aminocarbonyl)sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-(aminocarbonyl)thiopropanoic acid" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-carbamylthiopropionic acid" EXACT RESID-alternate [] +synonym: "beta-carbamylthioalanine" EXACT RESID-alternate [] +synonym: "MOD_RES S-carbamoylcysteine" EXACT UniProt-feature [] +synonym: "S-(aminocarbonyl)cysteine" EXACT RESID-alternate [] +synonym: "S-carbamoyl-L-cysteine" EXACT RESID-name [] +synonym: "S-carbamoylcysteine" EXACT RESID-alternate [] +synonym: "S-carbamylcysteine" EXACT RESID-alternate [] +synonym: "S-cysteinyl carbamate ester" EXACT RESID-alternate [] +synonym: "SCbmCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "43.02" +xref: DiffFormula: "C 1 H 1 N 1 O 1 S 0" +xref: DiffMono: "43.005814" +xref: Formula: "C 4 H 6 N 2 O 2 S 1" +xref: MassAvg: "146.16" +xref: MassMono: "146.014998" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00398 ! carbamoylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00338 +name: S-cyano-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine." [PubMed:12586941, PubMed:4808702, RESID:AA0333, UniMod:438#C] +synonym: "(2R)-2-amino-3-thiocyanatopropanoic acid" EXACT RESID-systematic [] +synonym: "alpha-amino-beta-thiocyanatopropionic acid" EXACT RESID-alternate [] +synonym: "beta-thiocyanatoalanine" EXACT RESID-alternate [] +synonym: "Cyano" RELATED PSI-MS-label [] +synonym: "cyano" RELATED UniMod-description [] +synonym: "MOD_RES S-cyanocysteine" EXACT UniProt-feature [] +synonym: "S-cyano-L-cysteine" EXACT RESID-name [] +synonym: "S-cyanocysteine" EXACT RESID-alternate [] +synonym: "serine thiocyanic acid ester" EXACT RESID-alternate [] +xref: DiffAvg: "25.01" +xref: DiffFormula: "C 1 H -1 N 1 O 0 S 0" +xref: DiffMono: "24.995249" +xref: Formula: "C 4 H 4 N 2 O 1 S 1" +xref: MassAvg: "128.15" +xref: MassMono: "128.004434" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00893 ! residues isobaric at 128.0-128.1 +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00339 +name: L-cysteinyl hydrogenase diiron subcluster +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster." [PubMed:10694885, PubMed:9836629, RESID:AA0334, UniMod:439#C] +comment: incidental to RESID:AA0140. +synonym: "1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile" EXACT RESID-alternate [] +synonym: "Diironsubcluster" RELATED PSI-MS-label [] +synonym: "hydrogenase diiron subcluster" RELATED UniMod-description [] +synonym: "L-cysteinyl hydrogenase diiron subcluster" EXACT RESID-name [] +synonym: "METAL Diiron subcluster" EXACT UniProt-feature [] +synonym: "mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron" EXACT RESID-systematic [] +xref: DiffAvg: "342.87" +xref: DiffFormula: "C 5 Fe 2 H -1 N 2 O 5 S 2" +xref: DiffMono: "342.786913" +xref: Formula: "C 8 Fe 2 H 4 N 3 O 6 S 3" +xref: MassAvg: "446.01" +xref: MassMono: "445.796098" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00738 ! iron containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00340 +name: S-amidino-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine." [PubMed:9148748, RESID:AA0335, UniMod:440#C] +synonym: "(2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-amidinosulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-amidinothiopropanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE Amidino-cysteine intermediate" EXACT UniProt-feature [] +synonym: "alpha-amino-beta-amidinothiopropionic acid" EXACT RESID-alternate [] +synonym: "Amidino" RELATED PSI-MS-label [] +synonym: "amidino" RELATED UniMod-description [] +synonym: "beta-(S-isothiourea)alanine" EXACT RESID-alternate [] +synonym: "beta-amidinothioalanine" EXACT RESID-alternate [] +synonym: "S-amidino-L-cysteine" EXACT RESID-name [] +synonym: "S-amidinocysteine" EXACT RESID-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 1 H 2 N 2 O 0 S 0" +xref: DiffMono: "42.021798" +xref: Formula: "C 4 H 7 N 3 O 1 S 1" +xref: MassAvg: "145.18" +xref: MassMono: "145.030983" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00341 +name: N-methyl-L-isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine." [PubMed:11875433, RESID:AA0336] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +synonym: "(2S,3S)-2-methylamino-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N-methylisoleucine" EXACT UniProt-feature [] +synonym: "N-methyl-L-isoleucine" EXACT RESID-name [] +synonym: "N-methylated L-isoleucine" EXACT PSI-MOD-alternate [] +synonym: "N-methylisoleucine" EXACT RESID-alternate [] +synonym: "NMe1Ile" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 13 N 1 O 1" +xref: MassAvg: "127.19" +xref: MassMono: "127.099714" +xref: Origin: "I" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00715 ! methylated isoleucine +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00342 +name: N-methyl-L-leucine +def: "A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine." [PubMed:11875433, RESID:AA0337] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +synonym: "(S)-2-methylamino-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-(methylamino)-4-methyl-valeric acid" EXACT RESID-alternate [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "MOD_RES N-methylleucine" EXACT UniProt-feature [] +synonym: "N-methyl-L-leucine" EXACT RESID-name [] +synonym: "N-methylated L-leucine" EXACT PSI-MOD-alternate [] +synonym: "N-methylleucine" EXACT RESID-alternate [] +synonym: "NMe1Leu" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 13 N 1 O 1" +xref: MassAvg: "127.19" +xref: MassMono: "127.099714" +xref: Origin: "L" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01680 ! alpha-amino monomethylated residue +is_a: MOD:01808 ! N-methylated leucine + +[Term] +id: MOD:00343 +name: N-methyl-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine." [DeltaMass:0, RESID:AA0338] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +synonym: "(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid" EXACT RESID-systematic [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "MOD_RES N-methyltyrosine" EXACT UniProt-feature [] +synonym: "N-methyl Tyrosinyl" EXACT DeltaMass-label [] +synonym: "N-methyl-L-tyrosine" EXACT RESID-name [] +synonym: "N-methylated L-tyrosine" EXACT PSI-MOD-alternate [] +synonym: "N-methyltyrosine" EXACT RESID-alternate [] +synonym: "NMe1Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 10 H 11 N 1 O 2" +xref: MassAvg: "177.20" +xref: MassMono: "177.078979" +xref: Origin: "Y" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00718 ! methylated tyrosine +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00344 +name: N-palmitoylglycine +def: "A protein modification that effectively converts a glycine residue to N-palmitoylglycine." [PubMed:12574119, RESID:AA0339] +comment: incidental to RESID:AA0060 +subset: PSI-MOD-slim +synonym: "(hexadecanamido)acetic acid" EXACT RESID-alternate [] +synonym: "(hexadecanoylamino)acetic acid" EXACT RESID-alternate [] +synonym: "(hexadecanoylamino)ethanoic acid" EXACT RESID-systematic [] +synonym: "LIPID N-palmitoyl glycine" EXACT UniProt-feature [] +synonym: "N-(1-oxohexadecyl)glycine" EXACT RESID-alternate [] +synonym: "N-palmitoyl-glycine" EXACT RESID-name [] +synonym: "N-palmitoylated glycine" EXACT PSI-MOD-alternate [] +synonym: "NPamGly" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "C 18 H 34 N 1 O 2" +xref: MassAvg: "296.47" +xref: MassMono: "296.258954" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01685 ! alpha-amino palmitoylated residue + +[Term] +id: MOD:00345 +name: 2-(S-L-cysteinyl)-L-phenylalanine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine." [PubMed:12696888, PubMed:3936839, RESID:AA0340] +comment: Cross-link 2. +synonym: "(2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "(2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid" EXACT RESID-alternate [] +synonym: "2-(L-cystein-S-yl)-L-phenylalanine" EXACT RESID-name [] +synonym: "alpha-(L-cystein-S-yl)-L-phenylalanine" EXACT RESID-alternate [] +synonym: "CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 12 H 12 N 2 O 2 S 1" +xref: MassAvg: "248.30" +xref: MassMono: "248.061949" +xref: Origin: "C, F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:00346 +name: 2-(S-L-cysteinyl)-D-phenylalanine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine." [PubMed:12696888, PubMed:3936839, RESID:AA0341] +comment: Cross-link 2. +synonym: "(2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "(2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid" EXACT RESID-alternate [] +synonym: "2-(L-cystein-S-yl)-D-phenylalanine" EXACT RESID-name [] +synonym: "alpha-(L-cystein-S-yl)-D-phenylalanine" EXACT RESID-alternate [] +synonym: "CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 12 H 12 N 2 O 2 S 1" +xref: MassAvg: "248.30" +xref: MassMono: "248.061949" +xref: Origin: "C, F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:00347 +name: 2-(S-L-cysteinyl)-D-allo-threonine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine." [PubMed:12696888, PubMed:3936839, RESID:AA0342] +comment: Cross-link 2. +synonym: "(2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid" EXACT RESID-alternate [] +synonym: "(2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic [] +synonym: "2-(L-cystein-S-yl)-D-allo-threonine" EXACT RESID-name [] +synonym: "alpha-(L-cystein-S-yl)-D-allo-threonine" EXACT RESID-alternate [] +synonym: "CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 7 H 10 N 2 O 3 S 1" +xref: MassAvg: "202.23" +xref: MassMono: "202.041213" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:00348 +name: N-carbamoyl-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine." [PubMed:12203680, RESID:AA0343] +synonym: "(S)-2-(carbamoylamino)propanoic acid" EXACT RESID-systematic [] +synonym: "2-ureidopropanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N-carbamoylalanine" EXACT UniProt-feature [] +synonym: "N-carbamoyl-L-alanine" EXACT RESID-name [] +synonym: "N-carbamylalanine" EXACT RESID-alternate [] +synonym: "N2CbmAla" EXACT PSI-MOD-label [] +xref: DiffAvg: "43.02" +xref: DiffFormula: "C 1 H 1 N 1 O 1" +xref: DiffMono: "43.005814" +xref: Formula: "C 4 H 7 N 2 O 2" +xref: MassAvg: "115.11" +xref: MassMono: "115.050752" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01679 ! alpha-aminocarbamoylated residue + +[Term] +id: MOD:00349 +name: 4-amino-3-isothiazolidinone-L-serine +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine." [PubMed:12802338, PubMed:12802339, RESID:AA0344] +comment: Cross-link 2. +synonym: "(2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid" EXACT RESID-alternate [] +synonym: "4-amino-3-isothiazolidinone-L-serine" EXACT RESID-alternate [] +synonym: "CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser)" EXACT UniProt-feature [] +synonym: "N,N-(L-cysteine-1,S-diyl)-L-serine" EXACT RESID-name [] +synonym: "serine-cysteine sulfenyl amide cross-link" EXACT RESID-alternate [] +synonym: "serine-cysteine sulphenyl amide cross-link" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 3 S 1" +xref: MassAvg: "188.20" +xref: MassMono: "188.025563" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01861 ! isothiazolidinone ring crosslinked residues + +[Term] +id: MOD:00350 +name: L-threonyl-pentaglycyl-murein peptidoglycan +def: "A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide." [PubMed:10754567, PubMed:1638631, RESID:AA0345] +synonym: "(2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine" EXACT RESID-alternate [] +synonym: "L-threonyl-pentaglycyl-murein peptidoglycan" EXACT RESID-name [] +synonym: "MOD_RES Pentaglycyl murein peptidoglycan amidated threonine" EXACT UniProt-feature [] +xref: DiffAvg: "268.25" +xref: DiffFormula: "C 10 H 14 N 5 O 4" +xref: DiffMono: "268.104579" +xref: Formula: "C 14 H 22 N 6 O 7" +xref: MassAvg: "386.37" +xref: MassMono: "386.154997" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01159 ! peptidoglycanated residue + +[Term] +id: MOD:00351 +name: N-glycyl-1-(phosphatidyl)ethanolamine +def: "A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine." [PubMed:11100732, RESID:AA0346] +synonym: "(R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane" EXACT RESID-systematic [] +synonym: "LIPID Phosphatidylethanolamine amidated glycine" EXACT UniProt-feature [] +synonym: "N-glycyl-1-(phosphatidyl)ethanolamine" EXACT RESID-name [] +synonym: "N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine" EXACT RESID-alternate [] +xref: DiffAvg: "699.99" +xref: DiffFormula: "C 39 H 74 N 1 O 7 P 1" +xref: DiffMono: "699.520290" +xref: Formula: "C 41 H 78 N 2 O 9 P 1" +xref: MassAvg: "774.05" +xref: MassMono: "773.544494" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00352 +name: L-glutamyl 5-omega-hydroxyceramide ester +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester." [PubMed:10411887, PubMed:9651377, RESID:AA0347] +synonym: "(S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine" EXACT RESID-alternate [] +synonym: "L-glutamyl 5-omega-hydroxyceramide ester" EXACT RESID-name [] +synonym: "LIPID Omega-hydroxyceramide glutamate ester" EXACT UniProt-feature [] +xref: DiffAvg: "761.31" +xref: DiffFormula: "C 50 H 96 N 0 O 4" +xref: DiffMono: "760.730862" +xref: Formula: "C 55 H 104 N 2 O 6" +xref: MassAvg: "889.44" +xref: MassMono: "888.789439" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00353 +name: S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium +def: "A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [PubMed:12172540, PubMed:16285713, RESID:AA0348] +comment: Cross-link 3. +synonym: "5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium" EXACT RESID-alternate [] +synonym: "S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium" EXACT RESID-name [] +xref: DiffAvg: "-3.02" +xref: DiffFormula: "C 0 H -3 N 0 O 0 S 0" +xref: DiffMono: "-3.024024" +xref: FormalCharge: "1+" +xref: Formula: "C 25 H 25 N 4 O 4 S 1" +xref: MassAvg: "477.56" +xref: MassMono: "477.159103" +xref: Origin: "M, W, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:00918 ! modified L-tryptophan residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00354 +name: O-(riboflavin phosphoryl)-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine." [PubMed:10587447, PubMed:11163785, PubMed:11248234, RESID:AA0349, UniMod:442#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid" EXACT RESID-systematic [] +synonym: "FMN" RELATED PSI-MS-label [] +synonym: "MOD_RES FMN phosphoryl threonine" EXACT UniProt-feature [] +synonym: "O-(riboflavin phosphoryl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(riboflavin phosphoryl)" RELATED UniMod-description [] +synonym: "O3-threonyl flavin mononucleotide" EXACT RESID-alternate [] +synonym: "O3-threonyl FMN" EXACT RESID-alternate [] +synonym: "OFMNThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "438.33" +xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1" +xref: DiffMono: "438.094050" +xref: Formula: "C 21 H 26 N 5 O 10 P 1" +xref: MassAvg: "539.44" +xref: MassMono: "539.141729" +xref: Origin: "T" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01164 ! riboflavin-phosphoryl + +[Term] +id: MOD:00355 +name: O-(riboflavin phosphoryl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine." [RESID:AA0350, UniMod:442#S] +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid" EXACT RESID-systematic [] +synonym: "FMN" RELATED PSI-MS-label [] +synonym: "MOD_RES FMN phosphoryl serine" EXACT UniProt-feature [] +synonym: "O-(riboflavin phosphoryl)-L-serine" EXACT RESID-name [] +synonym: "O3-(riboflavin phosphoryl)" RELATED UniMod-description [] +synonym: "O3-seryl flavin mononucleotide" EXACT RESID-alternate [] +synonym: "O3-seryl FMN" EXACT RESID-alternate [] +synonym: "OFMNSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "438.33" +xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1" +xref: DiffMono: "438.094050" +xref: Formula: "C 20 H 24 N 5 O 10 P 1" +xref: MassAvg: "525.41" +xref: MassMono: "525.126079" +xref: Origin: "S" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01164 ! riboflavin-phosphoryl + +[Term] +id: MOD:00356 +name: S-(4a-FMN)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine." [PubMed:12668455, PubMed:12846567, PubMed:7692961, RESID:AA0351, UniMod:443#C] +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "4a-(S-cysteinyl)flavin mononucleotide" EXACT RESID-alternate [] +synonym: "4a-(S-cysteinyl)FMN" EXACT RESID-alternate [] +synonym: "FMNC" RELATED PSI-MS-label [] +synonym: "MOD_RES S-4a-FMN cysteine" EXACT UniProt-feature [] +synonym: "S-(4a-FMN)" RELATED UniMod-description [] +synonym: "S-(4a-FMN)-L-cysteine" EXACT RESID-name [] +synonym: "S4aFMNCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "456.35" +xref: DiffFormula: "C 17 H 21 N 4 O 9 P 1 S 0" +xref: DiffMono: "456.104615" +xref: Formula: "C 20 H 26 N 5 O 10 P 1 S 1" +xref: MassAvg: "559.49" +xref: MassMono: "559.113800" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00896 ! FMN modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00357 +name: 1'-(8alpha-FMN)-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine." [PubMed:11902668, PubMed:8611516, RESID:AA0352, UniMod:409#H] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "1'-(8alpha-FMN)-L-histidine" EXACT RESID-name [] +synonym: "8alpha-(N(epsilon)-histidyl)FMN" EXACT RESID-alternate [] +synonym: "8alpha-(N1'-histidyl)FMN" EXACT RESID-alternate [] +synonym: "flavin mononucleotide" RELATED UniMod-description [] +synonym: "FMNH" RELATED PSI-MS-label [] +synonym: "MOD_RES Tele-8alpha-FMN histidine" EXACT UniProt-feature [] +synonym: "N(tau)-(8alpha-FMN)-histidine" EXACT RESID-alternate [] +synonym: "Ntele8aFMNHis" EXACT PSI-MOD-label [] +synonym: "tele-(8alpha-FMN)-histidine" EXACT RESID-alternate [] +xref: DiffAvg: "454.33" +xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1" +xref: DiffMono: "454.088965" +xref: Formula: "C 23 H 26 N 7 O 10 P 1" +xref: MassAvg: "591.47" +xref: MassMono: "591.147877" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00896 ! FMN modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00358 +name: 3'-(8alpha-FMN)-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine." [PubMed:12417325, RESID:AA0353, UniMod:409#H] +comment: In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "3'-(8alpha-FMN)-L-histidine" EXACT RESID-name [] +synonym: "8alpha-(N(delta)-histidyl)FMN" EXACT RESID-alternate [] +synonym: "8alpha-(N3'-histidyl)FMN" EXACT RESID-alternate [] +synonym: "flavin mononucleotide" RELATED UniMod-description [] +synonym: "FMNH" RELATED PSI-MS-label [] +synonym: "N(pi)-(8alpha-FMN)-histidine" EXACT RESID-alternate [] +synonym: "Npros8aFMNHis" EXACT PSI-MOD-label [] +synonym: "pros-(8alpha-FMN)-histidine" EXACT RESID-alternate [] +xref: DiffAvg: "454.33" +xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1" +xref: DiffMono: "454.088965" +xref: Formula: "C 23 H 26 N 7 O 10 P 1" +xref: MassAvg: "591.47" +xref: MassMono: "591.147877" +xref: Origin: "H" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00896 ! FMN modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00359 +name: N2-acetyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine." [PubMed:12883043, PubMed:1894641, RESID:AA0354] +synonym: "(S)-2-acetamido-5-carbamimidamidopentanoic acid" EXACT RESID-systematic [] +synonym: "2-acetamido-5-guanidinopentanoic acid" EXACT RESID-alternate [] +synonym: "2-acetylamino-5-guanidinopentanoic acid" EXACT RESID-alternate [] +synonym: "AcArg" EXACT PSI-MOD-label [] +synonym: "acetylarginine" EXACT RESID-alternate [] +synonym: "alpha-acetylamino-delta-guanidinovaleric acid" EXACT RESID-alternate [] +synonym: "MOD_RES N2-acetylarginine" EXACT UniProt-feature [] +synonym: "N(alpha)-acetylarginine" EXACT RESID-alternate [] +synonym: "N2-acetyl-L-arginine" EXACT RESID-name [] +synonym: "N2-acetylated L-arginine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 15 N 4 O 2" +xref: MassAvg: "199.23" +xref: MassMono: "199.119501" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00360 +name: L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide." [PubMed:12475995, RESID:AA0355, UniMod:444#C] +synonym: "[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide" EXACT RESID-systematic [] +synonym: "copper sulfido molybdopterin cytosine dinuncleotide" RELATED UniMod-description [] +synonym: "CuSMo" RELATED PSI-MS-label [] +synonym: "cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide" EXACT RESID-alternate [] +synonym: "L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide" EXACT RESID-name [] +xref: DiffAvg: "922.07" +xref: DiffFormula: "C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3" +xref: DiffMono: "922.834854" +xref: Formula: "C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4" +xref: MassAvg: "1025.20" +xref: MassMono: "1025.844039" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00742 ! copper containing modified residue +is_a: MOD:00744 ! molybdenum pterin containing modification +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00361 +name: tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [PubMed:11222759, PubMed:14704425, RESID:AA0356] +comment: Cross-link 3. +synonym: "METAL Iron-sulfur (4Fe-4S-S-AdoMet)" EXACT UniProt-feature [] +synonym: "tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron)" EXACT RESID-systematic [] +synonym: "tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide" EXACT RESID-name [] +xref: DiffAvg: "747.03" +xref: DiffFormula: "C 15 Fe 4 H 19 N 6 O 5 S 5" +xref: DiffMono: "746.742346" +xref: FormalCharge: "1-" +xref: Formula: "C 24 Fe 4 H 34 N 9 O 8 S 8" +xref: MassAvg: "1056.45" +xref: MassMono: "1055.769901" +xref: Origin: "C, C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00362 +name: tris-L-cysteinyl L-arginyl diiron disulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide." [PubMed:14704425, RESID:AA0357] +comment: Cross-link 4. +synonym: "di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron)" EXACT RESID-systematic [] +synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] +synonym: "tris-L-cysteinyl L-arginyl diiron disulfide" EXACT RESID-name [] +xref: DiffAvg: "172.79" +xref: DiffFormula: "C 0 Fe 2 H -3 N 0 O 0 S 2" +xref: DiffMono: "172.791639" +xref: FormalCharge: "2-" +xref: Formula: "C 15 Fe 2 H 24 N 7 O 4 S 5" +xref: MassAvg: "638.39" +xref: MassMono: "637.920304" +xref: Origin: "C, C, C, R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00363 +name: L-cysteinyl-L-selenocysteine (Cys-Sec) +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine." [PubMed:12911312, RESID:AA0358#SEC] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "(R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Cysteinyl-selenocysteine (Cys-Sec)" EXACT UniProt-feature [] +synonym: "CROSSLNK Cysteinyl-selenocysteine (Sec-Cys)" EXACT UniProt-feature [] +synonym: "L-cysteinyl-L-selenocysteine" EXACT RESID-name [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0 Se 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1" +xref: MassAvg: "251.17" +xref: MassMono: "251.947170" +xref: Origin: "C, U" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01158 ! modified L-selenocysteine residue +is_a: MOD:01627 ! L-cysteinyl-L-selenocysteine + +[Term] +id: MOD:00364 +name: 5-hydroxy-N6,N6,N6-trimethyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine." [PubMed:11349130, PubMed:14661085, RESID:AA0359, UniMod:445#K] +comment: Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074. +synonym: "(2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium" EXACT RESID-systematic [] +synonym: "(2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium" EXACT RESID-alternate [] +synonym: "(2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium" EXACT RESID-alternate [] +synonym: "5-hydroxy-N(zeta)-trimethyllysine" EXACT RESID-alternate [] +synonym: "5-hydroxy-N6,N6,N6-trimethyl" RELATED UniMod-description [] +synonym: "5-hydroxy-N6,N6,N6-trimethyl-L-lysine" EXACT RESID-name [] +synonym: "5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium" EXACT RESID-alternate [] +synonym: "5-hydroxy-N6,N6,N6-trimethyllysine cation" EXACT RESID-alternate [] +synonym: "5-hydroxylated N6,N6,N6-trimethylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "5HyN6Me3Lys" EXACT PSI-MOD-label [] +synonym: "alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid" EXACT RESID-alternate [] +synonym: "delta-hydroxy-epsilon-N,N,N-trimethyllysine" EXACT RESID-alternate [] +synonym: "Hydroxytrimethyl" RELATED PSI-MS-label [] +synonym: "lysine derivative Lys(z)" EXACT RESID-alternate [] +synonym: "MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine" EXACT UniProt-feature [] +xref: DiffAvg: "59.09" +xref: DiffFormula: "C 3 H 7 N 0 O 1" +xref: DiffMono: "59.049141" +xref: FormalCharge: "1+" +xref: Formula: "C 9 H 19 N 2 O 2" +xref: MassAvg: "187.26" +xref: MassMono: "187.144104" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00912 ! modified L-lysine residue +relationship: has_functional_parent MOD:00037 ! 5-hydroxy-L-lysine +relationship: has_functional_parent MOD:00083 ! N6,N6,N6-trimethyl-L-lysine + +[Term] +id: MOD:00365 +name: N-(L-isoglutamyl)-glycine +def: "A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine." [PubMed:14531691, RESID:AA0360] +comment: Cross-link 2. +synonym: "(S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N5-(carboxymethyl)-pentanediamic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu)" EXACT UniProt-feature [] +synonym: "isoglutamyl glycine" EXACT RESID-alternate [] +synonym: "N-(L-isoglutamyl)-glycine" EXACT RESID-name [] +synonym: "N-gamma-glutamylglycine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 9 N 2 O 3" +xref: MassAvg: "169.16" +xref: MassMono: "169.061317" +xref: Origin: "E, G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00366 +name: O-sulfo-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine." [PubMed:14752058, RESID:AA0361, UniMod:40#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(sulfooxy)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-hydroxypropanoic acid 3-sulfate" EXACT RESID-alternate [] +synonym: "MOD_RES Sulfoserine" EXACT UniProt-feature [] +synonym: "O-sulfo-L-serine" EXACT RESID-name [] +synonym: "O-Sulfonation" RELATED UniMod-description [] +synonym: "O3-sulfonoserine" EXACT RESID-alternate [] +synonym: "O3-sulfoserine" EXACT RESID-alternate [] +synonym: "serine sulfate ester" EXACT RESID-alternate [] +synonym: "Sulfo" RELATED PSI-MS-label [] +xref: DiffAvg: "80.06" +xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" +xref: DiffMono: "79.956815" +xref: Formula: "C 3 H 5 N 1 O 5 S 1" +xref: MassAvg: "167.13" +xref: MassMono: "166.988843" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00695 ! sulfated residue +is_a: MOD:00771 ! residues isobaric at 166.98-167.00 Da +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00367 +name: O-sulfo-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine." [PubMed:14752058, RESID:AA0362, UniMod:40#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(sulfooxy)butanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-hydroxybutanoic acid 3-sulfate" EXACT RESID-alternate [] +synonym: "MOD_RES Sulfothreonine" EXACT UniProt-feature [] +synonym: "O-sulfo-L-threonine" EXACT RESID-name [] +synonym: "O-Sulfonation" RELATED UniMod-description [] +synonym: "O3-sulfonothreonine" EXACT RESID-alternate [] +synonym: "O3-sulfothreonine" EXACT RESID-alternate [] +synonym: "Sulfo" RELATED PSI-MS-label [] +synonym: "threonine sulfate ester" EXACT RESID-alternate [] +xref: DiffAvg: "80.06" +xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" +xref: DiffMono: "79.956815" +xref: Formula: "C 4 H 7 N 1 O 5 S 1" +xref: MassAvg: "181.16" +xref: MassMono: "181.004493" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00695 ! sulfated residue +is_a: MOD:00773 ! residues isobaric at 181.00-181.02 Da +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00368 +name: N-carboxy-L-methionine +def: "A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine." [PubMed:10368287, PubMed:11120890, PubMed:12595263, PubMed:8312270, RESID:AA0363, UniMod:299#M] +comment: At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG]. +synonym: "(S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-carbamic-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "2-carbamic-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "Carboxy" RELATED UniMod-interim [] +synonym: "Carboxylation" RELATED UniMod-description [] +synonym: "N-carboxy-L-methionine" EXACT RESID-name [] +synonym: "N-carboxymethionine" EXACT RESID-alternate [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2 S 0" +xref: DiffMono: "43.989829" +xref: Formula: "C 6 H 10 N 1 O 3 S 1" +xref: MassAvg: "176.21" +xref: MassMono: "176.038139" +xref: Origin: "M" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:00369 +name: O-acetyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine." [ChEBI:17981, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:16731519, PubMed:489587, PubMed:7309355, RESID:AA0364, UniMod:1#S] +comment: incidental to RESID:AA0051 +subset: PSI-MOD-slim +synonym: "(2S)-3-(acetyloxy)-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "Acetylation" RELATED UniMod-description [] +synonym: "MOD_RES O-acetylserine" EXACT UniProt-feature [] +synonym: "O-acetyl-L-serine" EXACT RESID-name [] +synonym: "O-acetylated L-serine" EXACT PSI-MOD-alternate [] +synonym: "O-acetylserine" EXACT RESID-alternate [] +synonym: "OAcSer" EXACT PSI-MOD-label [] +synonym: "serine acetate ester" EXACT RESID-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00644 ! O-acetylated residue +is_a: MOD:00647 ! acetylated L-serine + +[Term] +id: MOD:00370 +name: (E)-2,3-didehydrotyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine." [PubMed:12623015, RESID:AA0365] +comment: incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 +subset: PSI-MOD-slim +synonym: "(2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid" EXACT RESID-systematic [] +synonym: "(E)-2,3-didehydrogenated tyrosine" EXACT PSI-MOD-alternate [] +synonym: "(E)-2,3-didehydrotyrosine" EXACT RESID-name [] +synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] +synonym: "amino-(para-hydroxybenzylidenyl)acetic acid" EXACT RESID-alternate [] +synonym: "blue non-fluorescent pocilloporin chromophore" EXACT RESID-alternate [] +synonym: "Didehydro" RELATED PSI-MS-label [] +synonym: "E-dHTyr" EXACT PSI-MOD-label [] +synonym: "MOD_RES (E)-2,3-didehydrotyrosine" EXACT UniProt-feature [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "trans-dehydrotyrosine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 9 H 7 N 1 O 2" +xref: MassAvg: "161.16" +xref: MassMono: "161.047678" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00706 ! dehydrogenated tyrosine + +[Term] +id: MOD:00371 +name: bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide +def: "A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide." [PubMed:14764885, RESID:AA0366] +comment: Cross-link 6. +synonym: "4Mn-Ca-4O cluster" EXACT RESID-alternate [] +synonym: "bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide" EXACT RESID-name [] +synonym: "mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese" EXACT RESID-systematic [] +synonym: "photosystem II catalytic cluster" EXACT RESID-alternate [] +xref: DiffAvg: "317.78" +xref: DiffFormula: "C 0 Ca 1 H -6 Mn 4 N 0 O 4" +xref: DiffMono: "317.647480" +xref: Formula: "C 29 Ca 1 H 32 Mn 4 N 8 O 20" +xref: MassAvg: "1072.44" +xref: MassMono: "1071.888057" +xref: Origin: "D, D, E, E, E, H" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00740 ! manganese containing modified residue +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01482 ! calcium containing modified residue + +[Term] +id: MOD:00372 +name: 3'-(3'-L-tyrosinyl)-L-tyrosine +def: "A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine." [DeltaMass:0, PubMed:14249161, PubMed:637884, PubMed:8702710, PubMed:8937563, RESID:AA0367] +comment: Cross-link 2; From DeltaMass: Average Mass: -2. +synonym: "(2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "3'-(L-tyros-3'-yl)-L-tyrosine" EXACT RESID-name [] +synonym: "3,3'-BiTyr (Crosslink)" EXACT DeltaMass-label [] +synonym: "6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid" EXACT RESID-alternate [] +synonym: "bityrosine" EXACT RESID-alternate [] +synonym: "o,o-dityrosine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 18 H 16 N 2 O 4" +xref: MassAvg: "324.34" +xref: MassMono: "324.111007" +xref: Origin: "Y, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00373 +name: 3'-(O4'-L-tyrosinyl)-L-tyrosine +def: "A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine." [DeltaMass:0, PubMed:12719529, PubMed:7115340, PubMed:8702710, RESID:AA0368] +comment: Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2. +synonym: "(2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid" EXACT RESID-alternate [] +synonym: "3'-(L-tyros-O4'-yl)-L-tyrosine" EXACT RESID-name [] +synonym: "CROSSLNK Isodityrosine (Tyr-Tyr)" EXACT UniProt-feature [] +synonym: "IsodiTyr (Crosslink)" EXACT DeltaMass-label [] +synonym: "isodityrosine" EXACT RESID-alternate [] +synonym: "O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 18 H 16 N 2 O 4" +xref: MassAvg: "324.34" +xref: MassMono: "324.111007" +xref: Origin: "Y, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00374 +name: 3,4-dihydroxy-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine." [PubMed:10978343, PubMed:12686488, RESID:AA0369, UniMod:425#R] +synonym: "(2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-5-guanidino-3,4-dihydroxypentanoic acid" EXACT RESID-alternate [] +synonym: "3,4-dihydroxy-L-arginine" EXACT RESID-name [] +synonym: "3,4-dihydroxylated L-arginine" EXACT PSI-MOD-alternate [] +synonym: "34Hy2Arg" EXACT PSI-MOD-label [] +synonym: "beta,gamma-dihydroxyarginine" EXACT RESID-alternate [] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "MOD_RES 3,4-dihydroxyarginine" EXACT UniProt-feature [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 12 N 4 O 3" +xref: MassAvg: "188.19" +xref: MassMono: "188.090940" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:00682 ! hydroxylated arginine + +[Term] +id: MOD:00375 +name: 4,5-dihydroxy-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine." [PubMed:10978343, PubMed:12686488, RESID:AA0370, UniMod:425#K] +synonym: "(2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid" EXACT RESID-systematic [] +synonym: "4,5-dihydroxy-L-lysine" EXACT RESID-name [] +synonym: "4,5-dihydroxylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "45Hy2Lys" EXACT PSI-MOD-label [] +synonym: "alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid" EXACT RESID-alternate [] +synonym: "delta,gamma-dihydroxylysine" EXACT RESID-alternate [] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "MOD_RES 4,5-dihydroxylysine" EXACT UniProt-feature [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 12 N 2 O 3" +xref: MassAvg: "160.17" +xref: MassMono: "160.084792" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:00681 ! hydroxylated lysine + +[Term] +id: MOD:00376 +name: 1'-(phospho-5'-adenosine)-L-histidine +def: "A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine." [PubMed:15182206, PubMed:9323207, RESID:AA0371, UniMod:405#H] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] +synonym: "1'-(phospho-5'-adenosine)-L-histidine" EXACT RESID-name [] +synonym: "ACT_SITE Tele-AMP-histidine intermediate" EXACT UniProt-feature [] +synonym: "AMP binding site" RELATED UniMod-description [] +synonym: "L-histidine 5'-adenosine phosphoramidester" EXACT RESID-alternate [] +synonym: "L-histidine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] +synonym: "N(tau)-5'-adenylic-L-histidine" EXACT RESID-alternate [] +synonym: "N1'-adenylylated histidine" EXACT RESID-alternate [] +synonym: "Phosphoadenosine" RELATED PSI-MS-label [] +synonym: "tele-5'-adenylic-L-histidine" EXACT RESID-alternate [] +xref: DiffAvg: "329.21" +xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" +xref: DiffMono: "329.052520" +xref: Formula: "C 16 H 19 N 8 O 7 P 1" +xref: MassAvg: "466.35" +xref: MassMono: "466.111432" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01165 ! adenylated residue + +[Term] +id: MOD:00377 +name: 1'-(phospho-5'-uridine)-L-histidine +def: "A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine." [PubMed:11467524, PubMed:321007, PubMed:380639, PubMed:8794735, RESID:AA0372, UniMod:417#H] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] +synonym: "1'-(phospho-5'-uridine)-L-histidine" EXACT RESID-name [] +synonym: "ACT_SITE Tele-UMP-histidine intermediate" EXACT UniProt-feature [] +synonym: "L-histidine 5'-uridine phosphoramidester" EXACT RESID-alternate [] +synonym: "L-histidine monoanhydride with 5'-uridylic acid" EXACT RESID-alternate [] +synonym: "N(tau)-5'-uridylic-L-histidine" EXACT RESID-alternate [] +synonym: "N1'-uridylylated histidine" EXACT RESID-alternate [] +synonym: "PhosphoUridine" RELATED PSI-MS-label [] +synonym: "tele-5'-uridylic-L-histidine" EXACT RESID-alternate [] +synonym: "uridine phosphodiester" RELATED UniMod-description [] +xref: DiffAvg: "306.17" +xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1" +xref: DiffMono: "306.025302" +xref: Formula: "C 15 H 18 N 5 O 9 P 1" +xref: MassAvg: "443.31" +xref: MassMono: "443.084214" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01166 ! uridylated residue + +[Term] +id: MOD:00378 +name: L-aspartyl semialdehyde +def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde." [PubMed:1093385, PubMed:14235557, PubMed:15237995, RESID:AA0373, UniMod:447#D] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "aspartyl 4-semialdehyde" EXACT PSI-MOD-alternate [] +synonym: "aspartyl aldehyde" EXACT PSI-MOD-alternate [] +synonym: "Deoxy" RELATED PSI-MS-label [] +synonym: "L-aminosuccinaldehydic acid" EXACT RESID-alternate [] +synonym: "L-aminosuccinic acid semialdehyde" EXACT RESID-alternate [] +synonym: "L-aspartate-beta-semialdehyde" EXACT RESID-alternate [] +synonym: "L-aspartic beta-semialdehyde" EXACT RESID-alternate [] +synonym: "L-aspartyl aldehyde" EXACT RESID-name [] +synonym: "L-beta-formylalanine" EXACT RESID-alternate [] +synonym: "MOD_RES Aspartyl aldehyde" EXACT UniProt-feature [] +synonym: "reduction" RELATED UniMod-description [] +xref: DiffAvg: "-16.00" +xref: DiffFormula: "C 0 H 0 N 0 O -1" +xref: DiffMono: "-15.994915" +xref: Formula: "C 4 H 5 N 1 O 2" +xref: MassAvg: "99.09" +xref: MassMono: "99.032028" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01161 ! deoxygenated residue + +[Term] +id: MOD:00379 +name: L-serine microcin E492 siderophore ester +def: "A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester." [PubMed:15102848, RESID:AA0374, UniMod:448#C-term] +comment: UniMod origin corrected [JSG]. +synonym: "L-serine microcin E492 siderophore ester" EXACT RESID-name [] +synonym: "Microcin" RELATED PSI-MS-label [] +synonym: "microcin E492 siderophore ester from serine" RELATED UniMod-description [] +synonym: "MOD_RES Serine microcin E492 siderophore ester" EXACT UniProt-feature [] +synonym: "N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine" EXACT RESID-systematic [] +xref: DiffAvg: "831.69" +xref: DiffFormula: "C 36 H 37 N 3 O 20" +xref: DiffMono: "831.197041" +xref: Formula: "C 39 H 43 N 4 O 23" +xref: MassAvg: "935.78" +xref: MassMono: "935.231809" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00380 +name: L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) +def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:12910261, PubMed:14725769, RESID:AA0375, UniMod:424#D] +synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] +synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum" EXACT RESID-systematic [] +synonym: "L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] +synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] +synonym: "MolybdopterinGD" RELATED PSI-MS-label [] +synonym: "nitrate reductase A aspartyl Mo-bisMGD cofactor" EXACT RESID-alternate [] +synonym: "phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester" EXACT RESID-alternate [] +xref: DiffAvg: "1572.02" +xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4" +xref: DiffMono: "1572.985775" +xref: Formula: "C 44 H 52 Mo 1 N 21 O 29 P 4 S 4" +xref: MassAvg: "1687.10" +xref: MassMono: "1688.012718" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01167 ! molybdopterin guanine dinucleotide + +[Term] +id: MOD:00381 +name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec) +def: "A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PubMed:11372198, PubMed:12220497, RESID:AA0376#SEC] +xref: DiffAvg: "1691.97" +xref: DiffFormula: "C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1" +xref: DiffMono: "1691.003369" +xref: Formula: "C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1" +xref: MassAvg: "1842.02" +xref: MassMono: "1841.957004" +xref: Origin: "U" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00746 ! tungsten containing modified residue +is_a: MOD:00748 ! pterin modified residue +is_a: MOD:01158 ! modified L-selenocysteine residue + +[Term] +id: MOD:00382 +name: 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one +def: "A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one." [PubMed:10852900, PubMed:11259412, PubMed:15491166, RESID:AA0377] +comment: carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one" EXACT RESID-systematic [] +synonym: "3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol" EXACT RESID-alternate [] +synonym: "3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one" EXACT RESID-name [] +synonym: "GFP-like chromoprotein asFP595 chromophore" EXACT RESID-alternate [] +synonym: "L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT RESID-alternate [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 14 H 15 N 2 O 2 S 1" +xref: MassAvg: "275.35" +xref: MassMono: "275.085424" +xref: Origin: "M, Y" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00383 +name: 2-imino-glutamic acid 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine." [PubMed:11682051, RESID:AA0378] +comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "2,N-didehydroglutamyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "2-imino-glutamic acid 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "2-imino-glutamyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid" EXACT RESID-systematic [] +synonym: "[2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly)" EXACT UniProt-feature [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 6 N 2 O 3" +xref: MassAvg: "166.14" +xref: MassMono: "166.037842" +xref: Origin: "E, G" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00384 +name: 2-imino-methionine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine." [PubMed:10852900, PubMed:12185250, PubMed:12909624, PubMed:15542608, RESID:AA0379] +comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "(2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid" EXACT RESID-alternate [] +synonym: "(2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2,N-didehydromethionyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "2-imino-methionine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "2-imino-methionyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly)" EXACT UniProt-feature [] +synonym: "GFP-like chromoprotein asFP595 chromophore" EXACT RESID-alternate [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "red fluorescent protein eqFP611 chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 8 N 2 O 1 S 1" +xref: MassAvg: "168.21" +xref: MassMono: "168.035734" +xref: Origin: "G, M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00385 +name: L-asparagine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine." [PubMed:10504696, RESID:AA0380] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "(2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "[2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] +synonym: "asparaginyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-imidazolinone (Asn-Gly)" EXACT UniProt-feature [] +synonym: "L-asparagine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "Zoanthus sp. fluorescent protein FP506 chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 7 N 3 O 2" +xref: MassAvg: "153.14" +xref: MassMono: "153.053826" +xref: Origin: "G, N" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00386 +name: L-lysine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine." [PubMed:10504696, RESID:AA0381] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "(2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "[2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] +synonym: "Anemonia majano fluorescent protein FP486 chromophore" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-imidazolinone (Lys-Gly)" EXACT UniProt-feature [] +synonym: "L-lysine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "lysyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 8 H 13 N 3 O 1" +xref: MassAvg: "167.21" +xref: MassMono: "167.105862" +xref: Origin: "G, K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00387 +name: 2-tetrahydropyridinyl-5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine." [PubMed:10504696, PubMed:15628861, RESID:AA0382] +comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. +synonym: "2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT RESID-name [] +synonym: "[5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-alternate [] +synonym: "[5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly)" EXACT UniProt-feature [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "Zoanthus sp. fluorescent protein zFP538 chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-37.06" +xref: DiffFormula: "C 0 H -7 N -1 O -1" +xref: DiffMono: "-37.052764" +xref: Formula: "C 8 H 9 N 2 O 1" +xref: MassAvg: "149.17" +xref: MassMono: "149.071488" +xref: Origin: "G, K" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00388 +name: L-alanyl-pentaglycyl-murein peptidoglycan +def: "A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide." [PubMed:8163519, RESID:AA0383] +synonym: "(2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine" EXACT RESID-alternate [] +synonym: "L-alanyl-pentaglycyl-murein peptidoglycan" EXACT RESID-name [] +synonym: "MOD_RES Pentaglycyl murein peptidoglycan amidated alanine" EXACT UniProt-feature [] +xref: DiffAvg: "268.25" +xref: DiffFormula: "C 10 H 14 N 5 O 4" +xref: DiffMono: "268.104579" +xref: Formula: "C 13 H 20 N 6 O 6" +xref: MassAvg: "356.34" +xref: MassMono: "356.144432" +xref: Origin: "A" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01159 ! peptidoglycanated residue + +[Term] +id: MOD:00389 +name: N-formyl-L-proline +def: "A protein modification that effectively converts an L-proline residue to N-formyl-L-proline." [PubMed:12051774, PubMed:5464655, RESID:AA0384, UniMod:122#N-term] +comment: CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG]. +synonym: "(2S)-1-formylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "1-formyl-2-pyrrolidinecarboxylic acid" EXACT RESID-alternate [] +synonym: "1-formylproline" EXACT RESID-alternate [] +synonym: "N-formyl-L-proline" EXACT RESID-name [] +synonym: "N-formylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "NFoPro" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 6 H 8 N 1 O 2" +xref: MassAvg: "126.14" +xref: MassMono: "126.055504" +xref: Origin: "P" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00390 +name: O-decanoyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine." [PubMed:12630926, RESID:AA0385, UniMod:449#S] +synonym: "(2S)-2-amino-3-(decanoyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "Decanoyl" RELATED PSI-MS-label [] +synonym: "L-serine decanoate ester" EXACT RESID-alternate [] +synonym: "lipid" RELATED UniMod-description [] +synonym: "LIPID O-decanoyl serine" EXACT UniProt-feature [] +synonym: "O-decanoyl-L-serine" EXACT RESID-name [] +synonym: "O-decanoylated L-serine" EXACT PSI-MOD-alternate [] +synonym: "O3-decanoyl-L-serine" EXACT RESID-alternate [] +synonym: "ODecSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "154.25" +xref: DiffFormula: "C 10 H 18 N 0 O 1" +xref: DiffMono: "154.135765" +xref: Formula: "C 13 H 23 N 1 O 3" +xref: MassAvg: "241.33" +xref: MassMono: "241.167794" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00668 ! O-decanoylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00391 +name: O-octanoyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine." [PubMed:11546772, PubMed:12716131, RESID:AA0386, UniMod:426#T] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(octanoyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "L-threonine octanoate ester" EXACT RESID-alternate [] +synonym: "LIPID O-octanoyl threonine" EXACT UniProt-feature [] +synonym: "O-octanoyl-L-threonine" EXACT RESID-name [] +synonym: "O-octanoylated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "O3-octanoyl-L-threonine" EXACT RESID-alternate [] +synonym: "Octanoyl" RELATED PSI-MS-label [] +synonym: "octanoyl" RELATED UniMod-description [] +synonym: "OOctThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "126.20" +xref: DiffFormula: "C 8 H 14 N 0 O 1" +xref: DiffMono: "126.104465" +xref: Formula: "C 12 H 21 N 1 O 3" +xref: MassAvg: "227.30" +xref: MassMono: "227.152144" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00669 ! O-octanoylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00392 +name: O-decanoyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine." [PubMed:11546772, RESID:AA0387, UniMod:449#T] +synonym: "(2S)-2-amino-3-(decanoyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "Decanoyl" RELATED PSI-MS-label [] +synonym: "L-threonine decanoate ester" EXACT RESID-alternate [] +synonym: "lipid" RELATED UniMod-description [] +synonym: "LIPID O-decanoyl threonine" EXACT UniProt-feature [] +synonym: "O-decanoyl-L-threonine" EXACT RESID-name [] +synonym: "O-decanoylated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "O3-decanoyl-L-threonine" EXACT RESID-alternate [] +synonym: "ODecThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "154.25" +xref: DiffFormula: "C 10 H 18 N 0 O 1" +xref: DiffMono: "154.135765" +xref: Formula: "C 14 H 25 N 1 O 3" +xref: MassAvg: "255.36" +xref: MassMono: "255.183444" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00668 ! O-decanoylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00393 +name: O-methylated residue +def: "A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OMeRes" EXACT PSI-MOD-label [] +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00394 +name: acetylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an acetyl group." [DeltaMass:0, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, UniMod:1] +comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42 +subset: PSI-MOD-slim +synonym: "Acetyl" RELATED PSI-MS-label [] +synonym: "Acetylation" RELATED UniMod-description [] +synonym: "Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac)" EXACT DeltaMass-label [] +synonym: "AcRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:00395 +name: thioester crosslinked residues +def: "A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00396 +name: O-glycosylated residue +def: "A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OGlycoRes" EXACT PSI-MOD-label [] +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00397 +name: iodoacetamide derivatized residue +def: "A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group." [PubMed:11327326, PubMed:11510821, PubMed:12422359, UniMod:4] +subset: PSI-MOD-slim +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00398 +name: carbamoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group." [DeltaMass:56, PubMed:10978403, PubMed:12203680, UniMod:5] +comment: This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG]. +subset: PSI-MOD-slim +synonym: "Carbamyl" RELATED UniMod-interim [] +synonym: "Carbamylation" EXACT DeltaMass-label [] +synonym: "Carbamylation" RELATED UniMod-description [] +xref: DiffAvg: "43.02" +xref: DiffFormula: "C 1 H 1 N 1 O 1" +xref: DiffMono: "43.005814" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00399 +name: iodoacetic acid derivatized residue +def: "A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group." [DeltaMass:64, UniMod:6] +comment: From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine. +subset: PSI-MOD-slim +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Carboxymethyl (on Cysteine)" EXACT DeltaMass-label [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00400 +name: deamidated residue +def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen." [DeltaMass:32, OMSSA:4, UniMod:7] +comment: From DeltaMass: References:Vish Katta. +subset: PSI-MOD-slim +synonym: "Deamidated" RELATED PSI-MS-label [] +synonym: "Deamidation" RELATED UniMod-description [] +synonym: "Deamidation of Asparagine and Glutamine to Aspartate and Glutamate" EXACT DeltaMass-label [] +synonym: "deamidationkq" EXACT OMSSA-label [] +synonym: "dNRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00401 +name: Gygi ICAT(TM) d0 modified cysteine +def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent." [PubMed:10504701, UniMod:8#C] +synonym: "Gygi ICAT(TM) d0" RELATED UniMod-description [] +synonym: "ICAT-G" RELATED PSI-MS-label [] +xref: DiffAvg: "486.63" +xref: DiffFormula: "C 22 H 38 N 4 O 6 S 1" +xref: DiffMono: "486.251206" +xref: Formula: "C 25 H 43 N 5 O 7 S 2" +xref: MassAvg: "589.77" +xref: MassMono: "589.260391" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine + +[Term] +id: MOD:00402 +name: Gygi ICAT(TM) d8 modified cysteine +def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent." [PubMed:10504701, UniMod:9#C] +synonym: "Gygi ICAT(TM) d8" RELATED UniMod-description [] +synonym: "ICAT-G:2H(8)" RELATED PSI-MS-label [] +xref: DiffAvg: "494.30" +xref: DiffFormula: "C 22 (1)H 30 (2)H 8 N 4 O 6 S 1" +xref: DiffMono: "494.301420" +xref: Formula: "C 25 (1)H 35 (2)H 8 N 5 O 7 S 2" +xref: MassAvg: "597.31" +xref: MassMono: "597.310605" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01431 ! (2)H deuterium tagged reagent +is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine + +[Term] +id: MOD:00403 +name: homoserine +def: "A protein modification that effectively converts an L-methionine residue to homoserine." [DeltaMass:113, OMSSA:56, UniMod:10#M] +comment: Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group. +subset: PSI-MOD-slim +synonym: "ctermpephsem" EXACT OMSSA-label [] +synonym: "Homoserine" RELATED UniMod-description [] +synonym: "Homoserine formed from Met by CNBr treatment" EXACT DeltaMass-label [] +synonym: "Met->Hse" RELATED PSI-MS-label [] +xref: DiffAvg: "-30.09" +xref: DiffFormula: "C -1 H -2 O 1 S -1" +xref: DiffMono: "-29.992806" +xref: Formula: "C 4 H 7 N 1 O 2" +xref: MassAvg: "101.10" +xref: MassMono: "101.047678" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00404 +name: homoserine lactone +def: "A protein modification that effectively converts an L-methionine residue to homoserine lactone." [DeltaMass:90, OMSSA:57, UniMod:11#M] +comment: Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone. +subset: PSI-MOD-slim +synonym: "ctermpephselactm" EXACT OMSSA-label [] +synonym: "Homoserine lactone" RELATED UniMod-description [] +synonym: "Met->Hsl" RELATED UniMod-interim [] +xref: DiffAvg: "-48.10" +xref: DiffFormula: "C -1 H -4 S -1" +xref: DiffMono: "-48.003371" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00405 +name: Applied Biosystems original ICAT(TM) d8 modified cysteine +def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent." [UniMod:12#C] +subset: PSI-MOD-slim +synonym: "Applied Biosystems original ICAT(TM) d8" RELATED UniMod-description [] +synonym: "ICAT-D:2H(8)" RELATED PSI-MS-label [] +xref: DiffAvg: "450.28" +xref: DiffFormula: "C 20 (1)H 26 (2)H 8 N 4 O 5 S 1" +xref: DiffMono: "450.275205" +xref: Formula: "C 23 (1)H 31 (2)H 8 N 5 O 6 S 2" +xref: MassAvg: "553.28" +xref: MassMono: "553.284390" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01431 ! (2)H deuterium tagged reagent +is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine + +[Term] +id: MOD:00406 +name: Applied Biosystems original ICAT(TM) d0 modified cysteine +def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent." [UniMod:13#C] +subset: PSI-MOD-slim +synonym: "Applied Biosystems original ICAT(TM) d0" RELATED UniMod-description [] +synonym: "ICAT-D" RELATED PSI-MS-label [] +xref: DiffAvg: "442.22" +xref: DiffFormula: "C 20 (1)H 34 N 4 O 5 S 1" +xref: DiffMono: "442.224991" +xref: Formula: "C 23 (1)H 39 N 5 O 6 S 2" +xref: MassAvg: "545.23" +xref: MassMono: "545.234176" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine + +[Term] +id: MOD:00407 +name: residue methyl ester +def: "A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because UniMod:14 merged with entry 34, remap to MOD:00599." [PubMed:18688235] +synonym: "ResOMe" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2" +xref: DiffMono: "14.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00408 +name: N-acetylated residue +def: "A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "N-Acetyl" EXACT PSI-MOD-alternate [] +synonym: "N-Acetylation" EXACT PSI-MOD-alternate [] +synonym: "NAcRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00394 ! acetylated residue +is_a: MOD:00670 ! N-acylated residue + +[Term] +id: MOD:00409 +name: N-formylated residue +def: "A protein modification that effectively replaces a residue amino group with a formamido group." [OMSSA:44, OMSSA:82] +subset: PSI-MOD-slim +synonym: "Formyl" RELATED PSI-MS-label [] +synonym: "NFoRes" EXACT PSI-MOD-label [] +synonym: "ntermformyl" EXACT OMSSA-label [] +synonym: "ntermpepformyl" EXACT OMSSA-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00493 ! formylated residue +is_a: MOD:00670 ! N-acylated residue + +[Term] +id: MOD:00410 +name: S-(N-isopropylcarboxamidomethyl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine." [OMSSA:84, PubMed:11465505, PubMed:8465942, UniMod:17#C] +synonym: "N-isopropylcarboxamidomethyl" RELATED UniMod-description [] +synonym: "NIPCAM" RELATED PSI-MS-label [] +synonym: "nipcam" EXACT OMSSA-label [] +xref: DiffAvg: "99.13" +xref: DiffFormula: "C 5 H 9 N 1 O 1 S 0" +xref: DiffMono: "99.068414" +xref: Formula: "C 8 H 14 N 2 O 2 S 1" +xref: MassAvg: "202.27" +xref: MassMono: "202.077599" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00411 +name: O18 label +def: "modification from UniMod Isotopic label. OBSOLETE because UniMod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label'" [PubMed:18688235] +comment: A modification from UniMod:18 +xref: DiffAvg: "2.00" +xref: DiffFormula: "(16)O -1 (18)O 1" +xref: DiffMono: "2.004246" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00412 +name: oxidation +def: "modification from UniMod artifact. OBSOLETE because UniMod entry 19 is now merged with UniMod 35 remap to MOD:00425 'monohydroxylated residue'." [PubMed:18688235] +xref: DiffAvg: "16.00" +xref: DiffFormula: "O 1" +xref: DiffMono: "15.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00413 +name: biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine +def: "A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine." [UniMod:20#C] +synonym: "Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine" RELATED UniMod-description [] +synonym: "PEO-Iodoacetyl-LC-Biotin" RELATED UniMod-interim [] +xref: DiffAvg: "414.52" +xref: DiffFormula: "C 18 H 30 N 4 O 5 S 1" +xref: DiffMono: "414.193691" +xref: Formula: "C 21 H 35 N 5 O 6 S 2" +xref: MassAvg: "517.66" +xref: MassMono: "517.202876" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00414 +name: monomethylated L-arginine +def: "A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group." [DeltaMass:215, OMSSA:77, UniMod:34#R] +comment: From DeltaMass: formula incorrect, N and O reversed +subset: PSI-MOD-slim +synonym: "Me1Arg" EXACT PSI-MOD-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methylr" EXACT OMSSA-label [] +synonym: "N-methyl Arginyl" EXACT DeltaMass-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 14 N 4 O 1" +xref: MassAvg: "170.22" +xref: MassMono: "170.116761" +xref: Origin: "R" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00658 ! methylated arginine + +[Term] +id: MOD:00415 +name: phosphorylation without neutral loss +def: "modification from UniMod - OBSOLETE because UniMod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'." [PubMed:18688235] +xref: DiffAvg: "79.98" +xref: DiffFormula: "H 1 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00416 +name: phosphorylation of an hydroxyl amino acid with prompt loss of phosphate +def: "A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment." [UniMod:23] +comment: O4-phosphotyrosine does not lose phosphate by this mechanism. UniMod does not provide a citation for this particular modification [JSG]. +subset: PSI-MOD-slim +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "H -2 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00432 ! modified residue with neutral loss of phosphate +is_a: MOD:00704 ! dehydrated residue + +[Term] +id: MOD:00417 +name: S-carboxamidoethyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine." [DeltaMass:72, OMSSA:5, PubMed:1481983, UniMod:24#C] +comment: From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys) +synonym: "Acrylamide adduct" RELATED UniMod-description [] +synonym: "PAM-Cys" EXACT DeltaMass-label [] +synonym: "Propionamide" RELATED PSI-MS-label [] +synonym: "Propionamide or Acrylamide adduct" EXACT DeltaMass-label [] +synonym: "propionamidec" EXACT OMSSA-label [] +synonym: "S-(3-amino-3-oxopropyl)cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-carbamoylethyl-L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-propanamide-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "71.08" +xref: DiffFormula: "C 3 H 5 N 1 O 1 S 0" +xref: DiffMono: "71.037114" +xref: Formula: "C 6 H 10 N 2 O 2 S 1" +xref: MassAvg: "174.22" +xref: MassMono: "174.046299" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00418 +name: pyridylacetylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group." [PubMed:9276974, UniMod:25] +comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. +synonym: "Pyridylacetyl" RELATED PSI-MS-label [] +synonym: "pyridylacetyl" RELATED UniMod-description [] +xref: DiffAvg: "119.12" +xref: DiffFormula: "C 7 H 5 N 1 O 1" +xref: DiffMono: "119.037114" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00419 +name: (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid +def: "A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid." [DeltaMass:336, PubMed:12643538, UniMod:26#C] +comment: From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue. +synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label [] +synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate [] +synonym: "Otc" EXACT DeltaMass-label [] +synonym: "Pyro-carbamidomethyl" RELATED UniMod-interim [] +synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" EXACT DeltaMass-label [] +synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED UniMod-description [] +xref: DiffAvg: "40.02" +xref: DiffFormula: "C 2 H 0 N 0 O 1 S 0" +xref: DiffMono: "39.994915" +xref: Formula: "C 5 H 6 N 1 O 2 S 1" +xref: MassAvg: "144.17" +xref: MassMono: "144.011924" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00420 +name: 2-pyrrolidone-5-carboxylic acid (Glu) +def: "A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid." [DeltaMass:16, OMSSA:109, PubMed:10214721, PubMed:1836357, PubMed:3473473, PubMed:8382902, RESID:AA0031#GLU, UniMod:27#E] +comment: From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG]. +synonym: "(2S)-5-oxo-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] +synonym: "2-oxopyrrolidine-5-carboxylic acid" EXACT RESID-alternate [] +synonym: "2-pyrrolidone-5-carboxylic acid" EXACT RESID-name [] +synonym: "5-oxoproline" EXACT RESID-alternate [] +synonym: "5-oxopyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] +synonym: "5-pyrrolidone-2-carboxylic acid" EXACT RESID-alternate [] +synonym: "Glu->pyro-Glu" RELATED PSI-MS-label [] +synonym: "MOD_RES Pyrrolidone carboxylic acid (Glu)" EXACT UniProt-feature [] +synonym: "ntermpeppyroe" EXACT OMSSA-label [] +synonym: "PCA" EXACT RESID-alternate [] +synonym: "PyrGlu(Glu)" EXACT PSI-MOD-label [] +synonym: "Pyro-glu from E" RELATED UniMod-description [] +synonym: "pyroglutamic acid" EXACT RESID-alternate [] +synonym: "Pyroglutamic Acid formed from Glutamic Acid" EXACT DeltaMass-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 6 N 1 O 2" +xref: MassAvg: "112.11" +xref: MassMono: "112.039853" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid + +[Term] +id: MOD:00421 +name: C-glycosylated residue +def: "A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "CGlycoRes" EXACT PSI-MOD-label [] +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00422 +name: alpha-amino morpholine-2-acetylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group." [PubMed:10446193, UniMod:29#N-term] +comment: The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. +synonym: "N-Succinimidyl-2-morpholine acetate" RELATED UniMod-description [] +synonym: "N-succinimidylmorpholine-2-acetate alpha-amino derivative" EXACT PSI-MOD-alternate [] +synonym: "SMA" RELATED PSI-MS-label [] +xref: DiffAvg: "127.14" +xref: DiffFormula: "C 6 H 9 N 1 O 2" +xref: DiffMono: "127.063329" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01696 ! alpha-amino acylated residue +is_a: MOD:01813 ! morpholine-2-acetylated residue + +[Term] +id: MOD:00423 +name: monosodium salt +def: "A protein modification that effectively substitutes one sodium atom for one hydrogen atom." [DeltaMass:0, UniMod:30] +subset: PSI-MOD-slim +synonym: "Cation:Na" RELATED PSI-MS-label [] +synonym: "Na1Res" EXACT PSI-MOD-label [] +synonym: "Sodium" EXACT DeltaMass-label [] +synonym: "Sodium adduct" RELATED UniMod-description [] +xref: DiffAvg: "21.98" +xref: DiffFormula: "H -1 Na 1" +xref: DiffMono: "21.981944" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00747 ! sodium containing modified residue + +[Term] +id: MOD:00424 +name: S-pyridylethyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine." [DeltaMass:253, OMSSA:112, PubMed:11760118, PubMed:626389, PubMed:8297018, PubMed:8783016, UniMod:31#C] +comment: From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex +synonym: "PECys" EXACT DeltaMass-label [] +synonym: "Pyridylethyl" RELATED PSI-MS-label [] +synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label [] +synonym: "S-pyridinylethyl-L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-pyridylethylation" RELATED UniMod-description [] +synonym: "spyridylethylc" EXACT OMSSA-label [] +synonym: "vinylpyridine derivatized cysteine residue" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "105.14" +xref: DiffFormula: "C 7 H 7 N 1" +xref: DiffMono: "105.057849" +xref: Formula: "C 10 H 12 N 2 O 1 S 1" +xref: MassAvg: "208.28" +xref: MassMono: "208.067034" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00425 +name: monohydroxylated residue +def: "A protein modification that effectively replaces one hydrogen atom with a hydroxyl group." [UniMod:35] +subset: PSI-MOD-slim +synonym: "Hy1Res" EXACT PSI-MOD-label [] +synonym: "Oxidation" RELATED UniMod-interim [] +synonym: "Oxidation or Hydroxylation" RELATED UniMod-description [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "O 1" +xref: DiffMono: "15.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "C-term" +is_a: MOD:00677 ! hydroxylated residue + +[Term] +id: MOD:00426 +name: S-glycosylated residue +def: "A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] +synonym: "SGlycoRes" EXACT PSI-MOD-label [] +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00427 +name: methylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a methyl group." [DeltaMass:36] +comment: From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355 +subset: PSI-MOD-slim +synonym: "MeRes" EXACT PSI-MOD-label [] +synonym: "Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine)" EXACT DeltaMass-label [] +is_a: MOD:00001 ! alkylated residue + +[Term] +id: MOD:00428 +name: dihydroxylated residue +def: "A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups." [PubMed:12686488, UniMod:425] +subset: PSI-MOD-slim +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "Hy2Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue + +[Term] +id: MOD:00429 +name: dimethylated residue +def: "A protein modification that effectively replaces two hydrogen atoms with two methyl groups." [DeltaMass:0, PubMed:12964758, PubMed:14570711, UniMod:36] +comment: For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG]. +subset: PSI-MOD-slim +synonym: "di-Methylation" RELATED UniMod-description [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "Me2Res" EXACT PSI-MOD-label [] +synonym: "N,N dimethylation (of Arginine or Lysine)" EXACT DeltaMass-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00430 +name: trimethylated residue +def: "A protein modification that effectively replaces three hydrogen atoms with three methyl groups." [PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, UniMod:37] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "Me3Res" EXACT PSI-MOD-label [] +synonym: "tri-Methylation" RELATED UniMod-description [] +synonym: "Trimethyl" RELATED PSI-MS-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6" +xref: DiffMono: "42.046950" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00431 +name: modified residue with a secondary neutral loss +def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NLModRes" EXACT PSI-MOD-label [] +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00432 +name: modified residue with neutral loss of phosphate +def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "dPhosModRes" EXACT PSI-MOD-label [] +is_a: MOD:00431 ! modified residue with a secondary neutral loss + +[Term] +id: MOD:00433 +name: glucosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "GlcRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00434 ! hexosylated residue +is_a: MOD:00726 ! glucosylated + +[Term] +id: MOD:00434 +name: hexosylated residue +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond." [DeltaMass:203, PubMed:15279557, UniMod:41] +comment: From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex. +subset: PSI-MOD-slim +synonym: "Hex" EXACT PSI-MOD-label [] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +synonym: "Hexoses (Fru, Gal, Glc, Man)" EXACT DeltaMass-label [] +synonym: "O-Glycosyl-" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00435 +name: O-phospho-L-serine with neutral loss of phosphate +def: "Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "dPhosOPhosSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "-97.99" +xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1" +xref: DiffMono: "-97.976895" +xref: Formula: "C 3 H 3 N 1 O 1" +xref: MassAvg: "69.06" +xref: MassMono: "69.021464" +xref: Origin: "MOD:00046" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01151 ! phosphorylated residue with neutral loss of phosphate +relationship: derives_from MOD:00046 ! O-phospho-L-serine + +[Term] +id: MOD:00436 +name: N-acetylhexosaminylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "HexNAc" EXACT PSI-MOD-label [] +synonym: "N-Acetylhexosamine" RELATED UniMod-description [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00437 +name: farnesylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a farnesyl group." [DeltaMass:0, PubMed:15609361, UniMod:44] +comment: From DeltaMass: Average Mass: 204 +subset: PSI-MOD-slim +synonym: "Farnesyl" RELATED PSI-MS-label [] +synonym: "Farnesylation" EXACT DeltaMass-label [] +synonym: "Farnesylation" RELATED UniMod-description [] +synonym: "FarnRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "204.36" +xref: DiffFormula: "C 15 H 24" +xref: DiffMono: "204.187801" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00703 ! isoprenylated residue + +[Term] +id: MOD:00438 +name: myristoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a myristoyl group." [DeltaMass:0, UniMod:45] +comment: From DeltaMass: Average Mass: 210 +subset: PSI-MOD-slim +synonym: "C14:0 aliphatic acylated residue" EXACT PSI-MOD-alternate [] +synonym: "Myristoyl" RELATED PSI-MS-label [] +synonym: "Myristoylation" EXACT DeltaMass-label [] +synonym: "Myristoylation" RELATED UniMod-description [] +synonym: "MyrRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "210.36" +xref: DiffFormula: "C 14 H 26 O 1" +xref: DiffMono: "210.198365" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00439 +name: O-phospho-L-threonine with neutral loss of phosphate +def: "Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "dPhosOPhosThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "-97.99" +xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1" +xref: DiffMono: "-97.976895" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "MOD:00047" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01151 ! phosphorylated residue with neutral loss of phosphate +relationship: derives_from MOD:00047 ! O-phospho-L-threonine + +[Term] +id: MOD:00440 +name: palmitoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a palmitoyl group." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 238 +subset: PSI-MOD-slim +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" EXACT DeltaMass-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +synonym: "PamRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 O 1" +xref: DiffMono: "238.229666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00441 +name: geranylgeranylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group." [DeltaMass:0, PubMed:15609361, UniMod:48] +comment: From DeltaMass: Average Mass: 272 +subset: PSI-MOD-slim +synonym: "Geranyl-geranyl" RELATED UniMod-description [] +synonym: "GeranylGeranyl" RELATED PSI-MS-label [] +synonym: "Geranylgeranylation" EXACT DeltaMass-label [] +synonym: "GergerRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "272.48" +xref: DiffFormula: "C 20 H 32" +xref: DiffMono: "272.250401" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00703 ! isoprenylated residue + +[Term] +id: MOD:00442 +name: protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide +def: "Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment." [PubMed:15835918, PubMed:18688235] +synonym: "dCDI-NNMe2+Arg" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 1 H 2 N 2 O 0" +xref: DiffMono: "42.021798" +xref: Formula: "C 7 H 14 N 2 O 1" +xref: MassAvg: "142.20" +xref: MassMono: "142.110613" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00431 ! modified residue with a secondary neutral loss +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00443 +name: protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine +def: "Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment." [PubMed:15835918, PubMed:18688235] +synonym: "dDMA-NoMe2+Arg" EXACT PSI-MOD-label [] +xref: DiffAvg: "59.09" +xref: DiffFormula: "C 2 H 7 N 2" +xref: DiffMono: "59.060923" +xref: Formula: "C 6 H 10 N 3 O 1" +xref: MassAvg: "140.17" +xref: MassMono: "140.082387" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00431 ! modified residue with a secondary neutral loss +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00444 +name: N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine." [OMSSA:118, PubMed:10356335, UniMod:51] +synonym: "N-acyl diglyceride cysteine" RELATED UniMod-description [] +synonym: "ntermpeptripalmitatec" EXACT OMSSA-label [] +synonym: "Tripalmitate" RELATED PSI-MS-label [] +xref: DiffAvg: "789.32" +xref: DiffFormula: "C 51 H 96 O 5" +xref: DiffMono: "788.725776" +xref: Formula: "C 54 H 101 N 1 O 6 S 1" +xref: MassAvg: "892.46" +xref: MassMono: "891.734961" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00899 ! N-palmitoyl-S-diacylglycerol-L-cysteine +relationship: has_functional_parent MOD:01144 ! S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine + +[Term] +id: MOD:00445 +name: L-homoarginine +def: "A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea." [OMSSA:53, PubMed:11078590, PubMed:11085420, PubMed:11821862, UniMod:52] +subset: PSI-MOD-slim +synonym: "Guanidination" RELATED UniMod-description [] +synonym: "guanidinationk" EXACT OMSSA-label [] +synonym: "Guanidinyl" RELATED PSI-MS-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 1 H 2 N 2" +xref: DiffMono: "42.021798" +xref: Formula: "C 7 H 14 N 4 O 1" +xref: MassAvg: "170.22" +xref: MassMono: "170.116761" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00446 +name: 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, UniMod:53] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] +synonym: "HNE" RELATED PSI-MS-label [] +xref: DiffAvg: "156.22" +xref: DiffFormula: "C 9 H 16 O 2" +xref: DiffMono: "156.115030" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00447 +name: N-glucuronylated residue +def: "A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation." [DeltaMass:0, PubMed:7398618, UniMod:54#N-term] +subset: PSI-MOD-slim +synonym: "Glucuronyl" RELATED PSI-MS-label [] +synonym: "N-Glucuronyl (N terminus)" EXACT DeltaMass-label [] +synonym: "N-glucuronylation" RELATED UniMod-description [] +xref: DiffAvg: "176.12" +xref: DiffFormula: "C 6 H 8 O 6" +xref: DiffMono: "176.032088" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00764 ! glycoconjugated residue + +[Term] +id: MOD:00448 +name: N-acetylaminoglucosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "GlcNAcRes" EXACT PSI-MOD-label [] +synonym: "HexNAc" RELATED PSI-MS-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00733 ! N-acetylaminoglucosylated +is_a: MOD:01673 ! N-acetylaminohexosylated residue + +[Term] +id: MOD:00449 +name: acetate labeling reagent (N-term) (heavy form, +3amu) +def: "modification from UniMod Isotopic label" [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:56] +synonym: "Acetate labeling reagent (N-term & K) (heavy form, +3amu)" RELATED UniMod-description [] +synonym: "Acetyl:2H(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "45.03" +xref: DiffFormula: "C 2 (1)H -1 (2)H 3 O 1" +xref: DiffMono: "45.029395" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00450 +name: acetate labeling reagent light form (K) +def: "OBSOLETE because this isotopic label from UniMod entry 57 is deprecated" [PubMed:11857757] +xref: DiffAvg: "42.01" +xref: DiffFormula: "C 2 (1)H 2 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00451 +name: alpha-amino propanoylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58#N-term] +synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] +synonym: "Propionyl" RELATED PSI-MS-label [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01894 ! propanoylated residue + +[Term] +id: MOD:00452 +name: alpha-amino 3x(13)C-labeled propanoylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:59#N-term] +synonym: "Propionate labeling reagent heavy form (+3amu), N-term & K" RELATED UniMod-description [] +synonym: "Propionyl:13C(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "59.04" +xref: DiffFormula: "(13)C 3 H 4 O 1" +xref: DiffMono: "59.036279" +xref: Formula: "(12)C 6 (13)C 3 H 16 N 2 O 2" +xref: MassAvg: "187.13" +xref: MassMono: "187.131242" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00451 ! alpha-amino propanoylated residue + +[Term] +id: MOD:00453 +name: quaternary amine labeling reagent light form (N-term & K) +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group." [PubMed:11857757, UniMod:60] +synonym: "GIST-Quat" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent light form (N-term & K)" RELATED UniMod-description [] +xref: DiffAvg: "127.19" +xref: DiffFormula: "C 7 H 13 N 1 O 1" +xref: DiffMono: "127.099714" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00454 +name: quaternary amine labeling reagent heavy form (+3amu) (N-term & K) +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group." [PubMed:11857757, UniMod:61] +synonym: "GIST-Quat:2H(3)" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent heavy (+3amu) form, N-term & K" RELATED UniMod-description [] +xref: DiffAvg: "130.12" +xref: DiffFormula: "C 7 (1)H 10 (2)H 3 N 1 O 1" +xref: DiffMono: "130.118544" +xref: Formula: "C 13 (1)H 22 (2)H 3 N 3 O 2" +xref: MassAvg: "258.21" +xref: MassMono: "258.213507" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00455 +name: quaternary amine labeling reagent heavy form (+6amu) (N-term & K) +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group." [PubMed:11857757, UniMod:62] +synonym: "GIST-Quat:2H(6)" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent heavy form (+6amu), N-term & K" RELATED UniMod-description [] +xref: DiffAvg: "133.14" +xref: DiffFormula: "C 7 H 7 (2)H 6 N 1 O 1" +xref: DiffMono: "133.137375" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00456 +name: quaternary amine labeling reagent heavy form (+9amu) (N-term & K) +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group." [PubMed:11857757, UniMod:63] +synonym: "GIST-Quat:2H(9)" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent heavy form (+9amu), N-term & K" RELATED UniMod-description [] +xref: DiffAvg: "136.16" +xref: DiffFormula: "C 7 (1)H 4 (2)H 9 N 1 O 1" +xref: DiffMono: "136.156205" +xref: Formula: "C 13 (1)H 16 (2)H 9 N 3 O 2" +xref: MassAvg: "264.25" +xref: MassMono: "264.251168" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00457 +name: alpha-amino succinylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group." [PubMed:11857757, PubMed:12175151, UniMod:64#N-term] +synonym: "Succinic anhydride labeling reagent light form (N-term)" RELATED UniMod-description [] +synonym: "Succinyl" RELATED PSI-MS-label [] +xref: DiffAvg: "100.02" +xref: DiffFormula: "(12)C 4 (1)H 4 O 3" +xref: DiffMono: "100.016044" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:01029 ! succinylated residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00458 +name: 4x(2)H labeled alpha-amino succinylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group." [PubMed:11857757, PubMed:12175151, UniMod:65#N-term] +synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term" RELATED UniMod-description [] +synonym: "Succinyl:2H(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "104.04" +xref: DiffFormula: "C 4 (2)H 4 O 3" +xref: DiffMono: "104.041151" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00457 ! alpha-amino succinylated residue + +[Term] +id: MOD:00459 +name: 4x(13)C labeled alpha-amino succinylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group." [PubMed:11857757, PubMed:12175151, UniMod:66#N-term] +synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K" RELATED UniMod-description [] +synonym: "Succinyl:13C(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "104.03" +xref: DiffFormula: "(13)C 4 H 4 O 3" +xref: DiffMono: "104.029463" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00457 ! alpha-amino succinylated residue + +[Term] +id: MOD:00460 +name: L-cysteic acid (L-cysteine sulfonic acid) +def: "A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid." [ChEBI:17285, DeltaMass:334, OMSSA:34, PubMed:14678012, PubMed:18306178, PubMed:19522542, PubMed:9252331, RESID:AA0556, UniMod:345#C] +comment: From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. +subset: PSI-MOD-slim +synonym: "(2R)-2-amino-3-sulfopropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-2-carboxyethanesulfonic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-sulfopropanoic acid" EXACT RESID-alternate [] +synonym: "3-sulfoalanine" EXACT RESID-alternate [] +synonym: "Cya" EXACT DeltaMass-label [] +synonym: "CysO3H" EXACT PSI-MOD-label [] +synonym: "cysteic acid" EXACT RESID-alternate [] +synonym: "Cysteic acid, oxidation of cysteine" EXACT DeltaMass-label [] +synonym: "cysteicacidc" EXACT OMSSA-label [] +synonym: "cysteine oxidation to cysteic acid" RELATED UniMod-description [] +synonym: "cysteine sulphonic acid" EXACT RESID-alternate [] +synonym: "L-cysteine sulfonic acid" EXACT RESID-name [] +synonym: "Trioxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "48.00" +xref: DiffFormula: "C 0 H 0 N 0 O 3 S 0" +xref: DiffMono: "47.984744" +xref: Formula: "C 3 H 5 N 1 O 4 S 1" +xref: MassAvg: "151.14" +xref: MassMono: "150.993929" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00708 ! sulfur oxygenated L-cysteine + +[Term] +id: MOD:00461 +name: nitrosylation +def: "A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom." [DeltaMass:0, PubMed:8839040, PubMed:9252331, UniMod:354] +comment: Note, this is often misrepresented as the introduction of a nitrate (NO3) group [JSG]. +subset: PSI-MOD-slim +synonym: "Nitro" RELATED PSI-MS-label [] +synonym: "Nitro (NO2)" EXACT DeltaMass-label [] +synonym: "Oxidation to nitro" RELATED UniMod-description [] +xref: DiffAvg: "45.00" +xref: DiffFormula: "H -1 N 1 O 2" +xref: DiffMono: "44.985078" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00462 +name: L-kynurenine +def: "A protein modification that effectively converts an L-tryptophan residue to L-kynurenine." [DeltaMass:357, OMSSA:66, PubMed:11029593, PubMed:9252331, UniMod:351#W] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid" EXACT PSI-MOD-alternate [] +synonym: "kynureninw" EXACT OMSSA-label [] +synonym: "Trp->Kynurenin" RELATED PSI-MS-label [] +synonym: "tryptophan oxidation to kynurenin" RELATED UniMod-description [] +xref: DiffAvg: "3.99" +xref: DiffFormula: "C -1 O 1" +xref: DiffMono: "3.994915" +xref: Formula: "C 10 H 10 N 2 O 2" +xref: MassAvg: "190.20" +xref: MassMono: "190.074228" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00463 +name: 3'-hydroxy-L-kynurenine +def: "A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine." [OMSSA:58, PubMed:9252331, UniMod:350#W] +subset: PSI-MOD-slim +synonym: "hydroxykynureninw" EXACT OMSSA-label [] +synonym: "Trp->Hydroxykynurenin" RELATED PSI-MS-label [] +synonym: "tryptophan oxidation to hydroxykynurenin" RELATED UniMod-description [] +xref: DiffAvg: "19.99" +xref: DiffFormula: "C -1 O 2" +xref: DiffMono: "19.989829" +xref: Formula: "C 10 H 10 N 2 O 3" +xref: MassAvg: "206.20" +xref: MassMono: "206.069142" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00464 +name: N'-formyl-L-kynurenine +def: "A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine." [DeltaMass:356, OMSSA:45, PubMed:12124932, PubMed:12686488, PubMed:9252331, UniMod:425#W] +comment: From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg. +subset: PSI-MOD-slim +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +synonym: "Double oxidation of Trp" EXACT DeltaMass-label [] +synonym: "formylkynureninw" EXACT OMSSA-label [] +synonym: "tryptophan oxidation to formylkynurenin" RELATED UniMod-alternate [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 11 H 10 N 2 O 3" +xref: MassAvg: "218.21" +xref: MassMono: "218.069142" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00465 +name: dihydroxyphenylalanine (Phe) +def: "A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine." [OMSSA:39, PubMed:1610822, PubMed:1903612, PubMed:3734192, PubMed:9252331, RESID:AA0146#var, UniMod:425#F] +comment: Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG]. +subset: PSI-MOD-slim +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "dihydroxyf" EXACT OMSSA-label [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 9 H 9 N 1 O 3" +xref: MassAvg: "179.17" +xref: MassMono: "179.058243" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:00466 +name: glycosylsphingolipidinositolated residue +def: "A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated." [PubMed:12626404, PubMed:18688235, PubMed:8404891] +synonym: "GSIRes" EXACT PSI-MOD-label [] +is_a: MOD:00764 ! glycoconjugated residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00467 +name: iminobiotinyl modified residue +def: "A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom." [PubMed:9750125, UniMod:89] +synonym: "Iminobiotin" RELATED PSI-MS-label [] +synonym: "Iminobiotinylation" RELATED UniMod-description [] +xref: DiffAvg: "225.31" +xref: DiffFormula: "C 10 H 15 N 3 O 1 S 1" +xref: DiffMono: "225.093583" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00468 +name: ESP-Tag light d0 +def: "modification from UniMod Isotopic label" [UniMod:90] +synonym: "ESP" RELATED PSI-MS-label [] +synonym: "ESP-Tag light d0" RELATED UniMod-description [] +xref: DiffAvg: "338.47" +xref: DiffFormula: "C 16 H 26 N 4 O 2 S 1" +xref: DiffMono: "338.177647" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00469 +name: ESP-Tag heavy d10 +def: "modification from UniMod Isotopic label" [UniMod:91] +synonym: "ESP-Tag heavy d10" RELATED UniMod-description [] +synonym: "ESP:2H(10)" RELATED PSI-MS-label [] +xref: DiffAvg: "348.24" +xref: DiffFormula: "C 16 (1)H 16 (2)H 10 N 4 O 2 S 1" +xref: DiffMono: "348.240415" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00470 +name: NHS-LC-Biotin +def: "modification from UniMod Chemical derivative" [UniMod:92] +synonym: "NHS-LC-Biotin" RELATED UniMod-interim [] +synonym: "NHS-LC-Biotin" RELATED UniMod-description [] +xref: DiffAvg: "339.45" +xref: DiffFormula: "C 16 H 25 N 3 O 3 S 1" +xref: DiffMono: "339.161663" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00471 +name: EDT-maleimide-PEO-biotin +def: "modification from UniMod Chemical derivative" [UniMod:93] +synonym: "EDT-maleimide-PEO-biotin" RELATED UniMod-interim [] +synonym: "EDT-maleimide-PEO-biotin" RELATED UniMod-description [] +xref: DiffAvg: "601.80" +xref: DiffFormula: "C 25 H 39 N 5 O 6 S 3" +xref: DiffMono: "601.206247" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00472 +name: IMID d0 +def: "modification from UniMod Isotopic label" [PubMed:11746907, UniMod:94, URL:http\://dx.doi.org/10.1002/rcm.517] +synonym: "IMID" RELATED PSI-MS-label [] +synonym: "IMID d0" RELATED UniMod-description [] +xref: DiffAvg: "68.04" +xref: DiffFormula: "C 3 (1)H 4 N 2" +xref: DiffMono: "68.037448" +xref: Formula: "C 9 H 16 N 4 O 1" +xref: MassAvg: "196.13" +xref: MassMono: "196.132411" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00473 +name: IMID d4 +def: "modification from UniMod Isotopic label" [PubMed:11746907, UniMod:95, URL:http\://dx.doi.org/10.1002/rcm.517] +synonym: "IMID d4" RELATED UniMod-description [] +synonym: "IMID:2H(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "72.06" +xref: DiffFormula: "C 3 (2)H 4 N 2" +xref: DiffMono: "72.062555" +xref: Formula: "C 9 (1)H 12 (2)H 4 N 4 O 1" +xref: MassAvg: "200.16" +xref: MassMono: "200.157518" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00474 +name: S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine." [UniMod:97#C] +synonym: "Acrylamide d3" RELATED UniMod-description [] +synonym: "Propionamide:2H(3)" RELATED PSI-MS-label [] +synonym: "S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-([1,1,2-(2)H3]-propanamide)-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "74.06" +xref: DiffFormula: "C 3 (1)H 2 (2)H 3 N 1 O 1" +xref: DiffMono: "74.055944" +xref: Formula: "C 6 (1)H 7 (2)H 3 N 2 O 2 S 1" +xref: MassAvg: "177.07" +xref: MassMono: "177.065129" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00417 ! S-carboxamidoethyl-L-cysteine +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00475 +name: tyrosine oxidation to 2-aminotyrosine +def: "modification from UniMod Chemical derivative" [PubMed:8839040, PubMed:9252331, UniMod:342#Y] +comment: May be misdescribed. Name (if not misdescribed) should be 2'-aminotyrosine [JSG]. +synonym: "Amino" RELATED PSI-MS-label [] +synonym: "Tyrosine oxidation to 2-aminotyrosine" RELATED UniMod-description [] +xref: DiffAvg: "15.02" +xref: DiffFormula: "H 1 N 1" +xref: DiffMono: "15.010899" +xref: Formula: "C 9 H 10 N 2 O 2" +xref: MassAvg: "178.19" +xref: MassMono: "178.074228" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00476 +name: galactosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "GalRes" EXACT PSI-MOD-label [] +is_a: MOD:00434 ! hexosylated residue +is_a: MOD:00728 ! galactosylated + +[Term] +id: MOD:00477 +name: 2-pyrrolidone +def: "A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain." [PubMed:2161657, PubMed:9252331, UniMod:360#P] +comment: The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the UniMod entry. +synonym: "Pro->Pyrrolidinone" RELATED PSI-MS-label [] +synonym: "Proline oxidation to pyrrolidinone" RELATED UniMod-description [] +xref: DiffAvg: "-13.02" +xref: DiffFormula: "C -1 H -1 N 0 O 0" +xref: DiffMono: "-13.007825" +xref: Formula: "C 4 H 6 N 1 O 1" +xref: MassAvg: "84.10" +xref: MassMono: "84.044939" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00683 ! dehydrogenated residue +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:00960 ! decarboxylated residue + +[Term] +id: MOD:00478 +name: glutamyl semialdehyde (Pro) +def: "A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde." [DeltaMass:354, PubMed:11120890, PubMed:2563380, PubMed:9252331, UniMod:35#P] +synonym: "gamma-glutamyl semialdehyde" EXACT PSI-MOD-alternate [] +synonym: "glutamyl 5-semialdehyde" EXACT PSI-MOD-alternate [] +synonym: "glutamyl aldehyde" EXACT PSI-MOD-alternate [] +synonym: "Oxidation" RELATED UniMod-interim [] +synonym: "Oxidation of proline to gamma-glutamyl semialdehyde" EXACT DeltaMass-label [] +synonym: "Oxidation or Hydroxylation" RELATED UniMod-description [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01440 ! glutamyl semialdehyde + +[Term] +id: MOD:00479 +name: glutamyl semialdehyde (Arg) +def: "A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde." [DeltaMass:351, PubMed:11120890, PubMed:1680314, PubMed:9252331, UniMod:344#R] +comment: From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. +synonym: "Arg->GluSA" RELATED PSI-MS-label [] +synonym: "Arginine oxidation to glutamic semialdehyde" RELATED UniMod-description [] +synonym: "Oxidation of arginine (to glutamic acid)" EXACT DeltaMass-label [] +xref: DiffAvg: "-43.07" +xref: DiffFormula: "C -1 H -5 N -3 O 1" +xref: DiffMono: "-43.053433" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01440 ! glutamyl semialdehyde + +[Term] +id: MOD:00480 +name: Applied Biosystems cleavable ICAT(TM) light +def: "modification from UniMod Isotopic label" [OMSSA:129, UniMod:105#C, URL:http\://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153] +subset: PSI-MOD-slim +synonym: "Applied Biosystems cleavable ICAT(TM) light" RELATED UniMod-description [] +synonym: "ICAT-C" RELATED PSI-MS-label [] +synonym: "icatlight" EXACT OMSSA-label [] +xref: DiffAvg: "227.26" +xref: DiffFormula: "C 10 H 17 N 3 O 3" +xref: DiffMono: "227.126991" +xref: Formula: "C 13 H 22 N 4 O 4 S 1" +xref: MassAvg: "330.40" +xref: MassMono: "330.136176" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00481 +name: Applied Biosystems cleavable ICAT(TM) heavy +def: "modification from UniMod Isotopic label" [OMSSA:130, UniMod:106#C, URL:http\://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153] +subset: PSI-MOD-slim +synonym: "Applied Biosystems cleavable ICAT(TM) heavy" RELATED UniMod-description [] +synonym: "ICAT-C:13C(9)" RELATED PSI-MS-label [] +synonym: "icatheavy" EXACT OMSSA-label [] +xref: DiffAvg: "236.16" +xref: DiffFormula: "(12)C 1 (13)C 9 H 17 N 3 O 3" +xref: DiffMono: "236.157185" +xref: Formula: "(12)C 4 (13)C 9 H 22 N 4 O 4 S 1" +xref: MassAvg: "339.17" +xref: MassMono: "339.166370" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent + +[Term] +id: MOD:00482 +name: N-formyl-L-methionine (Met) +def: "A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process)." [PubMed:11152118, PubMed:2165784, PubMed:3042771, RESID:AA0021#MET] +comment: This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG]. +synonym: "(2S)-2-formylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-formamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "2-formylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "2-formylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N-formylmethionine" EXACT UniProt-feature [] +synonym: "N-formyl-L-methionine" EXACT RESID-name [] +synonym: "N-formylated L-methionine" EXACT PSI-MOD-alternate [] +synonym: "NFoMet" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1 S 0" +xref: DiffMono: "27.994915" +xref: Formula: "C 6 H 10 N 1 O 2 S 1" +xref: MassAvg: "160.21" +xref: MassMono: "160.043225" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00030 ! N-formyl-L-methionine residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00483 +name: N-ethylmaleimide derivatized cysteine +def: "A protein modification that is produced by reaction with N-ethylmaleimide." [OMSSA:83, PubMed:11813307, PubMed:12777388, UniMod:108#C] +synonym: "N-ethylmaleimide on cysteines" RELATED UniMod-description [] +synonym: "nemc" EXACT OMSSA-label [] +synonym: "Nethylmaleimide" RELATED PSI-MS-label [] +xref: DiffAvg: "125.13" +xref: DiffFormula: "C 6 H 7 N 1 O 2" +xref: DiffMono: "125.047678" +xref: Formula: "C 9 H 12 N 2 O 3 S 1" +xref: MassAvg: "228.27" +xref: MassMono: "228.056863" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00484 +name: oxidized lysine biotinylated with biotin-LC-hydrazide, reduced +def: "modification from UniMod Chemical derivative" [UniMod:112#K] +synonym: "Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced" RELATED UniMod-description [] +synonym: "OxLysBiotinRed" RELATED UniMod-interim [] +xref: DiffAvg: "354.47" +xref: DiffFormula: "C 16 H 26 N 4 O 3 S 1" +xref: DiffMono: "354.172562" +xref: Formula: "C 22 H 38 N 6 O 4 S 1" +xref: MassAvg: "482.64" +xref: MassMono: "482.267525" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00485 +name: oxidized lysine biotinylated with biotin-LC-hydrazide +def: "modification from UniMod Chemical derivative" [UniMod:113#K] +synonym: "Oxidized lysine biotinylated with biotin-LC-hydrazide" RELATED UniMod-description [] +synonym: "OxLysBiotin" RELATED UniMod-interim [] +xref: DiffAvg: "352.45" +xref: DiffFormula: "C 16 H 24 N 4 O 3 S 1" +xref: DiffMono: "352.156912" +xref: Formula: "C 22 H 36 N 6 O 4 S 1" +xref: MassAvg: "480.63" +xref: MassMono: "480.251875" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00486 +name: oxidized proline biotinylated with biotin-LC-hydrazide, reduced +def: "modification from UniMod Chemical derivative" [UniMod:114#C] +synonym: "Oxidized proline biotinylated with biotin-LC-hydrazide, reduced" RELATED UniMod-description [] +synonym: "OxProBiotinRed" RELATED UniMod-interim [] +xref: DiffAvg: "371.50" +xref: DiffFormula: "C 16 H 29 N 5 O 3 S 1" +xref: DiffMono: "371.199111" +xref: Formula: "C 21 H 36 N 6 O 4 S 1" +xref: MassAvg: "468.62" +xref: MassMono: "468.251875" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00487 +name: oxidized proline biotinylated with biotin-LC-hydrazide +def: "modification from UniMod Chemical derivative" [UniMod:115#C] +synonym: "Oxidized Proline biotinylated with biotin-LC-hydrazide" RELATED UniMod-description [] +synonym: "OxProBiotin" RELATED UniMod-interim [] +xref: DiffAvg: "369.48" +xref: DiffFormula: "C 16 H 27 N 5 O 3 S 1" +xref: DiffMono: "369.183461" +xref: Formula: "C 21 H 34 N 6 O 4 S 1" +xref: MassAvg: "466.60" +xref: MassMono: "466.236225" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00488 +name: oxidized arginine biotinylated with biotin-LC-hydrazide +def: "modification from UniMod Chemical derivative" [UniMod:116#C] +synonym: "OxArgBiotin" RELATED UniMod-interim [] +synonym: "Oxidized arginine biotinylated with biotin-LC-hydrazide" RELATED UniMod-description [] +xref: DiffAvg: "310.41" +xref: DiffFormula: "C 15 H 22 N 2 O 3 S 1" +xref: DiffMono: "310.135114" +xref: Formula: "C 21 H 34 N 6 O 4 S 1" +xref: MassAvg: "466.60" +xref: MassMono: "466.236225" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00489 +name: oxidized arginine biotinylated with biotin-LC-hydrazide, reduced +def: "modification from UniMod Chemical derivative" [UniMod:117#C] +synonym: "OxArgBiotinRed" RELATED UniMod-interim [] +synonym: "Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced" RELATED UniMod-description [] +xref: DiffAvg: "312.43" +xref: DiffFormula: "C 15 H 24 N 2 O 3 S 1" +xref: DiffMono: "312.150764" +xref: Formula: "C 21 H 36 N 6 O 4 S 1" +xref: MassAvg: "468.62" +xref: MassMono: "468.251875" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00490 +name: EDT-iodo-PEO-biotin +def: "modification from UniMod Chemical derivative" [UniMod:118] +synonym: "EDT-iodo-PEO-biotin" RELATED UniMod-description [] +synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label [] +xref: DiffAvg: "490.70" +xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3" +xref: DiffMono: "490.174219" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00491 +name: thio ether formation - BTP Adduct +def: "modification from UniMod Chemical derivative" [PubMed:11861642, UniMod:119#C] +synonym: "IBTP" RELATED PSI-MS-label [] +synonym: "Thio Ether Formation - BTP Adduct" RELATED UniMod-description [] +xref: DiffAvg: "316.38" +xref: DiffFormula: "C 22 H 21 P 1" +xref: DiffMono: "316.138087" +xref: Formula: "C 25 H 26 N 1 O 1 P 1 S 1" +xref: MassAvg: "419.52" +xref: MassMono: "419.147272" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00492 +name: ubiquitination signature dipeptidyl lysine +def: "A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin." [OMSSA:52, PubMed:11125103, PubMed:12612601, PubMed:12872131, RESID:AA0125#var, UniMod:121#K] +synonym: "GlyGly" RELATED PSI-MS-label [] +synonym: "glyglyk" EXACT OMSSA-label [] +synonym: "N6-(glycylglycyl)lysine" EXACT PSI-MOD-alternate [] +synonym: "N6-glycylglycyl-L-lysine" EXACT PSI-MOD-alternate [] +synonym: "ubiquitinylation residue" RELATED UniMod-description [] +xref: DiffAvg: "114.10" +xref: DiffFormula: "C 4 H 6 N 2 O 2" +xref: DiffMono: "114.042927" +xref: Formula: "C 10 H 18 N 4 O 3" +xref: MassAvg: "242.28" +xref: MassMono: "242.137890" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01875 ! N6-acylated L-lysine +relationship: derives_from MOD:01148 ! ubiquitinylated lysine + +[Term] +id: MOD:00493 +name: formylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a formyl group." [DeltaMass:0, PubMed:15799070, UniMod:122] +comment: From DeltaMass: Average Mass: 28 +subset: PSI-MOD-slim +synonym: "FoRes" EXACT PSI-MOD-label [] +synonym: "Formyl" RELATED PSI-MS-label [] +synonym: "Formylation" RELATED UniMod-description [] +synonym: "Formylation (CHO)" EXACT DeltaMass-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:00494 +name: N-iodoacetyl, p-chlorobenzyl-12C6-glucamine +def: "modification from UniMod Isotopic label" [PubMed:12185208, UniMod:123#C] +synonym: "ICAT-H" RELATED PSI-MS-label [] +synonym: "N-iodoacetyl, p-chlorobenzyl-12C6-glucamine" RELATED UniMod-description [] +xref: DiffAvg: "345.78" +xref: DiffFormula: "C 15 Cl 1 H 20 N 1 O 6 S 0" +xref: DiffMono: "345.097915" +xref: Formula: "C 18 Cl 1 H 25 N 2 O 7 S 1" +xref: MassAvg: "448.91" +xref: MassMono: "448.107100" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00495 +name: N-iodoacetyl, p-chlorobenzyl-13C6-glucamine +def: "modification from UniMod Isotopic label" [PubMed:12185208, UniMod:124#C] +synonym: "ICAT-H:13C(6)" RELATED PSI-MS-label [] +synonym: "N-iodoacetyl, p-chlorobenzyl-13C6-glucamine" RELATED UniMod-description [] +xref: DiffAvg: "351.12" +xref: DiffFormula: "(12)C 9 (13)C 6 Cl 1 H 20 N 1 O 6 S 0" +xref: DiffMono: "351.118044" +xref: Formula: "(12)C 12 (13)C 6 Cl 1 H 25 N 2 O 7 S 1" +xref: MassAvg: "454.13" +xref: MassMono: "454.127229" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00496 +name: reductive amination-D +def: "OBSOLETE because UniMod entry 125 is merged with entry 199, remap to id: MOD:00552" [UniMod:125] +xref: DiffAvg: "32.06" +xref: DiffFormula: "C 2 (2)H 4" +xref: DiffMono: "32.056407" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00497 +name: 3-sulfanylpropanoyl (N-term and Lys) +def: "modification from UniMod [(35)S]dithiobis(succinimidyl propionate) crosslinking" [PubMed:957432, UniMod:126] +comment: The name "thioacylation of primary amines" in UniMod was a misdescription [JSG]. +synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED UniMod-alternate [] +synonym: "3-sulfanylpropanoyl" RELATED UniMod-description [] +synonym: "Thioacyl" RELATED PSI-MS-label [] +xref: DiffAvg: "88.12" +xref: DiffFormula: "C 3 H 4 O 1 S 1" +xref: DiffMono: "87.998286" +xref: Formula: "C 9 H 16 N 2 O 2 S 1" +xref: MassAvg: "216.30" +xref: MassMono: "216.093249" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00498 +name: fluorinated residue +def: "A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom." [PubMed:18688235] +synonym: "Fluoro" RELATED PSI-MS-label [] +synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] +synonym: "Fluorophenylalanyl" EXACT DeltaMass-label [] +synonym: "FRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue + +[Term] +id: MOD:00499 +name: 5-iodoacetamidofluorescein +def: "modification from UniMod Chemical derivative" [PubMed:3311742, PubMed:3578767, UniMod:128#C] +synonym: "5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR)" RELATED UniMod-description [] +synonym: "Fluorescein" RELATED PSI-MS-label [] +xref: DiffAvg: "388.35" +xref: DiffFormula: "C 22 H 14 N 1 O 6" +xref: DiffMono: "388.082112" +xref: Formula: "C 25 H 19 N 2 O 7 S 1" +xref: MassAvg: "491.49" +xref: MassMono: "491.091297" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00500 +name: monoiodinated residue +def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom." [DeltaMass:0, PubMed:15627961, PubMed:2026710, UniMod:129] +comment: From DeltaMass: Average Mass: 126 +subset: PSI-MOD-slim +synonym: "I1Res" EXACT PSI-MOD-label [] +synonym: "Iodination" RELATED UniMod-description [] +synonym: "Iodination (of Histidine[C4] or Tyrosine[C3])" EXACT DeltaMass-label [] +synonym: "Iodo" RELATED PSI-MS-label [] +xref: DiffAvg: "125.90" +xref: DiffFormula: "H -1 I 1" +xref: DiffMono: "125.896648" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00755 ! iodinated residue + +[Term] +id: MOD:00501 +name: diiodinated residue +def: "A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms." [UniMod:130] +comment: From DeltaMass: Average Mass: 252 +subset: PSI-MOD-slim +synonym: "di-Iodination" RELATED UniMod-description [] +synonym: "Diiodo" RELATED PSI-MS-label [] +synonym: "I2Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "251.79" +xref: DiffFormula: "H -2 I 2" +xref: DiffMono: "251.793295" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00755 ! iodinated residue + +[Term] +id: MOD:00502 +name: triiodinated residue +def: "A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms." [OMSSA:116, PubMed:15627961, PubMed:2026710, UniMod:131] +comment: From UniMod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG]. +subset: PSI-MOD-slim +synonym: "I3Res" EXACT PSI-MOD-label [] +synonym: "tri-Iodination" RELATED UniMod-description [] +synonym: "triiodinationy" EXACT OMSSA-label [] +synonym: "Triiodo" RELATED PSI-MS-label [] +xref: DiffAvg: "377.69" +xref: DiffFormula: "H -3 I 3" +xref: DiffMono: "377.689943" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00755 ! iodinated residue + +[Term] +id: MOD:00503 +name: N-(cis-delta 5)-tetradecaenoylglycine +def: "A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine." [OMSSA:78, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059#var, UniMod:134#G] +synonym: "(cis-delta 5)-tetradecaenoyl" RELATED UniMod-description [] +synonym: "Myristoleyl" RELATED PSI-MS-label [] +synonym: "myristoleylation (one double bond)" EXACT DeltaMass-label [] +synonym: "N-(C14:1 aliphatic acyl)glycine" EXACT PSI-MOD-alternate [] +synonym: "ntermpepmyristoyeylationg" EXACT OMSSA-label [] +xref: DiffAvg: "208.35" +xref: DiffFormula: "C 14 H 24 N 0 O 1" +xref: DiffMono: "208.182715" +xref: Formula: "C 16 H 27 N 1 O 2" +xref: MassAvg: "265.40" +xref: MassMono: "265.204179" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00504 +name: N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine +def: "A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine." [OMSSA:79, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059#var, UniMod:135#G] +synonym: "(cis,cis-delta 5, delta 8)-tetradecadienoyl" RELATED UniMod-description [] +synonym: "Myristoyl+Delta:H(-4)" RELATED PSI-MS-label [] +synonym: "myristoylation-4H (two double bonds)" EXACT DeltaMass-label [] +synonym: "N-(C14:2 aliphatic acyl)glycine" EXACT PSI-MOD-alternate [] +synonym: "ntermpepmyristoyl4hg" EXACT OMSSA-label [] +xref: DiffAvg: "206.33" +xref: DiffFormula: "C 14 H 22 O 1" +xref: DiffMono: "206.167065" +xref: Formula: "C 16 H 25 N 1 O 2" +xref: MassAvg: "263.38" +xref: MassMono: "263.188529" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:00505 +name: benzoyl labeling reagent light form (N-term and K) +def: "modification from UniMod Isotopic label" [DeltaMass:0, PubMed:15456300, UniMod:136] +comment: From DeltaMass: Average Mass: 104 +synonym: "Benzoyl" RELATED PSI-MS-label [] +synonym: "Benzoyl (Bz)" EXACT DeltaMass-label [] +synonym: "labeling reagent light form (N-term & K)" RELATED UniMod-description [] +xref: DiffAvg: "104.11" +xref: DiffFormula: "C 7 H 4 O 1" +xref: DiffMono: "104.026215" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00506 +name: N-linked glycan core +def: "modification from UniMod N-linked glycosylation, Hex(5) HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:137#N] +synonym: "Hex(5)HexNAc(2)" RELATED PSI-MS-label [] +synonym: "N-linked glycan core" RELATED UniMod-description [] +xref: DiffAvg: "1217.09" +xref: DiffFormula: "C 46 H 76 N 2 O 35" +xref: DiffMono: "1216.422862" +xref: Formula: "C 50 H 82 N 4 O 37" +xref: MassAvg: "1331.20" +xref: MassMono: "1330.465790" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00507 +name: 5-dimethylaminonaphthalene-1-sulfonyl +def: "OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653." [DeltaMass:0, UniMod:139] +comment: From DeltaMass: Average Mass: 233 +synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] +synonym: "Dansyl" RELATED PSI-MS-label [] +synonym: "Dansyl (Dns)" EXACT DeltaMass-label [] +xref: DiffAvg: "233.29" +xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" +xref: DiffMono: "233.051050" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00508 +name: ISD a-series (C-Term) +def: "modification from UniMod Other" [PubMed:14588022, UniMod:140] +comment: Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer. +synonym: "a-type-ion" RELATED PSI-MS-label [] +synonym: "ISD a-series (C-Term)" RELATED UniMod-description [] +xref: DiffAvg: "-29.02" +xref: DiffFormula: "C -1 H -1 O -1" +xref: DiffMono: "-29.002740" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00509 +name: amidination of lysines or N-terminal amines with methyl acetimidate +def: "modification from UniMod Chemical derivative" [PubMed:12643539, PubMed:6273432, UniMod:141] +synonym: "amidination of lysines or N-terminal amines with methyl acetimidate" RELATED UniMod-description [] +synonym: "Amidine" RELATED PSI-MS-label [] +xref: DiffAvg: "41.05" +xref: DiffFormula: "C 2 H 3 N 1" +xref: DiffMono: "41.026549" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00510 +name: HexNAc1dHex1 +def: "modification from UniMod N-linked glycosylation, dHex HexNAc" [OMSSA:183, PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:142] +synonym: "dHexHexNAcN" EXACT OMSSA-label [] +synonym: "HexNAc(1)dHex(1)" RELATED PSI-MS-label [] +synonym: "HexNAc1dHex1" RELATED UniMod-description [] +xref: DiffAvg: "349.34" +xref: DiffFormula: "C 14 H 23 N 1 O 9" +xref: DiffMono: "349.137281" +xref: Formula: "C 18 H 29 N 3 O 11" +xref: MassAvg: "463.44" +xref: MassMono: "463.180209" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00511 +name: HexNAc2 +def: "modification from UniMod N-linked glycosylation, HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:143] +synonym: "HexNAc(2)" RELATED PSI-MS-label [] +synonym: "HexNAc2" RELATED UniMod-description [] +xref: DiffAvg: "406.39" +xref: DiffFormula: "C 16 H 26 N 2 O 10" +xref: DiffMono: "406.158745" +xref: Formula: "C 20 H 32 N 4 O 12" +xref: MassAvg: "520.49" +xref: MassMono: "520.201672" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00512 +name: Hex3 +def: "modification from UniMod N-linked glycosylation, Hex3" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:144] +synonym: "Hex(3)" RELATED PSI-MS-label [] +synonym: "Hex3" RELATED UniMod-description [] +xref: DiffAvg: "486.42" +xref: DiffFormula: "C 18 H 30 O 15" +xref: DiffMono: "486.158470" +xref: Formula: "C 22 H 36 N 2 O 17" +xref: MassAvg: "600.53" +xref: MassMono: "600.201398" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00513 +name: HexNAc1dHex2 +def: "modification from UniMod N-linked glycosylation, dHex(2) HexNAc" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:145] +synonym: "HexNAc(1)dHex(2)" RELATED PSI-MS-label [] +synonym: "HexNAc1dHex2" RELATED UniMod-description [] +xref: DiffAvg: "495.48" +xref: DiffFormula: "C 20 H 33 N 1 O 13" +xref: DiffMono: "495.195190" +xref: Formula: "C 24 H 39 N 3 O 15" +xref: MassAvg: "609.58" +xref: MassMono: "609.238118" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00514 +name: Hex1HexNAc1dHex1 +def: "modification from UniMod N-linked glycosylation, dHex Hex HexNAc" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:146] +synonym: "Hex(1)HexNAc(1)dHex(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1dHex1" RELATED UniMod-description [] +xref: DiffAvg: "511.48" +xref: DiffFormula: "C 20 H 33 N 1 O 14" +xref: DiffMono: "511.190105" +xref: Formula: "C 24 H 39 N 3 O 16" +xref: MassAvg: "625.58" +xref: MassMono: "625.233032" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00515 +name: HexNAc2dHex1 +def: "modification from UniMod N-linked glycosylation, dHex HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:147] +synonym: "HexNAc(2)dHex(1)" RELATED PSI-MS-label [] +synonym: "HexNAc2dHex1" RELATED UniMod-description [] +xref: DiffAvg: "552.53" +xref: DiffFormula: "C 22 H 36 N 2 O 14" +xref: DiffMono: "552.216654" +xref: Formula: "C 26 H 42 N 4 O 16" +xref: MassAvg: "666.63" +xref: MassMono: "666.259581" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00516 +name: Hex1HexNAc2 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:148] +synonym: "Hex(1)HexNAc(2)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc2" RELATED UniMod-description [] +xref: DiffAvg: "568.53" +xref: DiffFormula: "C 22 H 36 N 2 O 15" +xref: DiffMono: "568.211568" +xref: Formula: "C 26 H 42 N 4 O 17" +xref: MassAvg: "682.63" +xref: MassMono: "682.254496" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00517 +name: Hex1HexNAc1NeuAc1 glycosylated residue +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [DeltaMass:0, UniMod:149] +comment: From DeltaMass: Average Mass: 657 +synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] +synonym: "NeuAc-Hex-HexNAc" EXACT DeltaMass-label [] +xref: DiffAvg: "657.60" +xref: DiffFormula: "C 25 H 41 N 2 O 18" +xref: DiffMono: "657.235437" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00518 +name: HexNAc2dHex2 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:150] +synonym: "HexNAc(2)dHex(2)" RELATED PSI-MS-label [] +synonym: "HexNAc2dHex2" RELATED UniMod-description [] +xref: DiffAvg: "698.67" +xref: DiffFormula: "C 28 H 46 N 2 O 18" +xref: DiffMono: "698.274563" +xref: Formula: "C 32 H 52 N 4 O 20" +xref: MassAvg: "812.78" +xref: MassMono: "812.317490" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00519 +name: Hex1HexNAc2Pent1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:151] +synonym: "Hex(1)HexNAc(2)Pent(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc2Pent1" RELATED UniMod-description [] +xref: DiffAvg: "700.64" +xref: DiffFormula: "C 27 H 44 N 2 O 19" +xref: DiffMono: "700.253827" +xref: Formula: "C 31 H 50 N 4 O 21" +xref: MassAvg: "814.75" +xref: MassMono: "814.296755" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00520 +name: Hex1HexNAc2dHex1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:152] +synonym: "Hex(1)HexNAc(2)dHex(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc2dHex1" RELATED UniMod-description [] +xref: DiffAvg: "714.67" +xref: DiffFormula: "C 28 H 46 N 2 O 19" +xref: DiffMono: "714.269477" +xref: Formula: "C 32 H 52 N 4 O 21" +xref: MassAvg: "828.77" +xref: MassMono: "828.312405" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00521 +name: Hex2HexNAc2 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:153] +synonym: "Hex(2)HexNAc(2)" RELATED PSI-MS-label [] +synonym: "Hex2HexNAc2" RELATED UniMod-description [] +xref: DiffAvg: "730.67" +xref: DiffFormula: "C 28 H 46 N 2 O 20" +xref: DiffMono: "730.264392" +xref: Formula: "C 32 H 52 N 4 O 22" +xref: MassAvg: "844.77" +xref: MassMono: "844.307319" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00522 +name: Hex3HexNAc1Pent1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:154] +synonym: "Hex(3)HexNAc(1)Pent(1)" RELATED PSI-MS-label [] +synonym: "Hex3HexNAc1Pent1" RELATED UniMod-description [] +xref: DiffAvg: "821.73" +xref: DiffFormula: "C 31 H 51 N 1 O 24" +xref: DiffMono: "821.280102" +xref: Formula: "C 35 H 57 N 3 O 26" +xref: MassAvg: "935.84" +xref: MassMono: "935.323029" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00523 +name: Hex1HexNAc2dHex1Pent1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:155] +synonym: "Hex(1)HexNAc(2)dHex(1)Pent(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc2dHex1Pent1" RELATED UniMod-description [] +xref: DiffAvg: "846.79" +xref: DiffFormula: "C 33 H 54 N 2 O 23" +xref: DiffMono: "846.311736" +xref: Formula: "C 35 H 57 N 3 O 26" +xref: MassAvg: "935.84" +xref: MassMono: "935.323029" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00524 +name: Hex1HexNAc2dHex2 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:156] +synonym: "Hex(1)HexNAc(2)dHex(2)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc2dHex2" RELATED UniMod-description [] +xref: DiffAvg: "860.81" +xref: DiffFormula: "C 34 H 56 N 2 O 23" +xref: DiffMono: "860.327386" +xref: Formula: "C 38 H 62 N 4 O 25" +xref: MassAvg: "974.92" +xref: MassMono: "974.370313" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00525 +name: Hex2HexNAc2Pent1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:157] +synonym: "Hex(2)HexNAc(2)Pent(1)" RELATED PSI-MS-label [] +synonym: "Hex2HexNAc2Pent1" RELATED UniMod-description [] +xref: DiffAvg: "862.79" +xref: DiffFormula: "C 33 H 54 N 2 O 24" +xref: DiffMono: "862.306651" +xref: Formula: "C 37 H 60 N 4 O 26" +xref: MassAvg: "976.89" +xref: MassMono: "976.349578" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00526 +name: Hex2HexNAc2dHex1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:158] +synonym: "Hex(2)HexNAc(2)dHex(1)" RELATED PSI-MS-label [] +synonym: "Hex2HexNAc2dHex1" RELATED UniMod-description [] +xref: DiffAvg: "876.81" +xref: DiffFormula: "C 34 H 56 N 2 O 24" +xref: DiffMono: "876.322301" +xref: Formula: "C 38 H 62 N 4 O 26" +xref: MassAvg: "990.92" +xref: MassMono: "990.365228" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00527 +name: Hex3HexNAc2 +def: "modification from UniMod N-linked glycosylation" [DeltaMass:0, RESID:AA0151#var, UniMod:159] +comment: From DeltaMass: Average Mass: 893 +synonym: "(Hex)3-HexNAc-HexNAc" EXACT DeltaMass-label [] +synonym: "Hex(3)HexNAc(2)" RELATED PSI-MS-label [] +synonym: "Hex3HexNAc2" RELATED UniMod-description [] +xref: DiffAvg: "892.81" +xref: DiffFormula: "C 34 H 56 N 2 O 25" +xref: DiffMono: "892.317215" +xref: Formula: "C 38 H 62 N 4 O 27" +xref: MassAvg: "1006.92" +xref: MassMono: "1006.360143" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00528 +name: Hex1HexNAc1NeuAc2 glycosylated residue +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [UniMod:160] +synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] +xref: DiffAvg: "947.85" +xref: DiffFormula: "C 36 H 57 N 3 O 26" +xref: DiffMono: "947.323029" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00529 +name: Hex3HexNAc2P1 +def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:161] +synonym: "Hex(3)HexNAc(2)P(1)" RELATED PSI-MS-label [] +synonym: "Hex3HexNAc2P1" RELATED UniMod-description [] +xref: DiffAvg: "972.79" +xref: DiffFormula: "C 34 H 57 N 2 O 28 P 1" +xref: DiffMono: "972.283546" +xref: Formula: "C 38 H 63 N 4 O 30 P 1" +xref: MassAvg: "1086.89" +xref: MassMono: "1086.326473" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00530 +name: L-selenomethionine +def: "A protein modification that effectively converts an L-methionine residue to L-selenomethionine." [OMSSA:113, PubMed:12148805, UniMod:162#M] +synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] +synonym: "Se(S)Met" EXACT PSI-MOD-label [] +synonym: "Selenium replaces sulphur" RELATED UniMod-description [] +synonym: "semetm" EXACT OMSSA-label [] +xref: DiffAvg: "46.91" +xref: DiffFormula: "C 0 H 0 N 0 S -1 Se 1" +xref: DiffMono: "47.944450" +xref: Formula: "C 5 H 9 N 1 O 1 Se 1" +xref: MassAvg: "178.10" +xref: MassMono: "178.984935" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00007 ! selenium substitution for sulfur +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00531 +name: (18)O labeled deglycosylated asparagine +def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water." [PubMed:14435542, UniMod:170] +subset: PSI-MOD-slim +synonym: "Delta:H(1)O(-1)18O(1)" RELATED PSI-MS-label [] +synonym: "glycosylated asparagine 18O labeling" RELATED UniMod-description [] +xref: DiffAvg: "2.99" +xref: DiffFormula: "H -1 N -1 (18)O 1" +xref: DiffMono: "2.988262" +xref: Formula: "C 4 H 5 N 1 (16)O 2 (18)O 1" +xref: MassAvg: "117.03" +xref: MassMono: "117.031189" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01293 ! 1x(18)O labeled deamidated L-asparagine + +[Term] +id: MOD:00532 +name: Shimadzu 13CNBS +def: "modification from UniMod Chemical derivative" [PubMed:12845591, UniMod:171] +synonym: "NBS:13C(6)" RELATED UniMod-interim [] +synonym: "Shimadzu NBS-13C" RELATED UniMod-description [] +xref: DiffAvg: "159.01" +xref: DiffFormula: "(13)C 6 H 3 N 1 O 2 S 1" +xref: DiffMono: "159.008578" +xref: Formula: "(12)C 11 (13)C 6 H 13 N 3 O 3 S 1" +xref: MassAvg: "345.09" +xref: MassMono: "345.087891" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00533 +name: Shimadzu 12CNBS +def: "modification from UniMod Chemical derivative" [PubMed:12845591, UniMod:172] +synonym: "NBS" RELATED UniMod-interim [] +synonym: "Shimadzu NBS-12C" RELATED UniMod-description [] +xref: DiffAvg: "152.99" +xref: DiffFormula: "(12)C 6 H 3 N 1 O 2 S 1" +xref: DiffMono: "152.988449" +xref: Formula: "(12)C 17 H 13 N 3 O 3 S 1" +xref: MassAvg: "339.07" +xref: MassMono: "339.067762" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00534 +name: Michael addition of BHT quinone methide to cysteine and lysine +def: "modification from UniMod Post-translational" [PubMed:9448752, UniMod:176] +comment: Butylated Hydroxytoluene adduct. +synonym: "BHT" RELATED PSI-MS-label [] +synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] +xref: DiffAvg: "218.34" +xref: DiffFormula: "C 15 H 22 O 1" +xref: DiffMono: "218.167065" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00535 +name: phosphorylation to amine thiol +def: "modification from UniMod Chemical derivative" [PubMed:12216740, UniMod:178] +comment: DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site. +synonym: "DAET" RELATED PSI-MS-label [] +synonym: "phosphorylation to amine thiol" RELATED UniMod-description [] +xref: DiffAvg: "87.18" +xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1" +xref: DiffMono: "87.050656" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00536 +name: L-serine to L-alanine replacement +def: "OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue" [UniMod:179] +synonym: "Ser_Ala" EXACT PSI-MOD-label [] +xref: DiffAvg: "-16.00" +xref: DiffFormula: "O -1" +xref: DiffMono: "-15.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00537 +name: L-alanine residue (Thr) +def: "A protein modification that effectively converts an L-threonine residue to L-alanine." [UniMod:659] +comment: This could represent either an engineered replacement or a chemical modification. +synonym: "Thr(Ala)" EXACT PSI-MOD-label [] +synonym: "Thr->Ala" RELATED UniMod-interim [] +synonym: "Thr->Ala substitution" RELATED UniMod-description [] +xref: DiffAvg: "-30.03" +xref: DiffFormula: "C -1 H -2 O -1" +xref: DiffMono: "-30.010565" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "T" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00010 ! L-alanine residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00538 +name: protein modification categorized by isobaric sets +def: "Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00000 ! protein modification + +[Term] +id: MOD:00539 +name: threonine reduced to aminobutynate +def: "OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? modification from UniMod O-linked glycosylation" [UniMod:182] +xref: DiffAvg: "-17.01" +xref: DiffFormula: "H -1 O -1" +xref: DiffMono: "-17.002740" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00540 +name: 9x(13)C labeled residue +def: "A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue." [PubMed:12716131, UniMod:184] +synonym: "13C(9) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(9)" RELATED PSI-MS-label [] +xref: DiffAvg: "9.03" +xref: DiffFormula: "(12)C -9 (13)C 9" +xref: DiffMono: "9.030194" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue + +[Term] +id: MOD:00541 +name: 9x(13)C labeled L-phosphotyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine." [PubMed:12716131, UniMod:185] +synonym: "C13 label (Phosphotyrosine)" RELATED UniMod-description [] +synonym: "Label:13C(9)+Phospho" RELATED PSI-MS-label [] +xref: DiffAvg: "89.00" +xref: DiffFormula: "(12)C -9 (13)C 9 H 1 O 3 P 1" +xref: DiffMono: "88.996524" +xref: Formula: "(13)C 9 H 10 N 1 O 5 P 1" +xref: MassAvg: "252.06" +xref: MassMono: "252.059853" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00540 ! 9x(13)C labeled residue +is_a: MOD:00919 ! modified L-tyrosine residue +relationship: derives_from MOD:00048 ! O4'-phospho-L-tyrosine + +[Term] +id: MOD:00542 +name: hydroxyphenylglyoxal arginine +def: "modification from UniMod Chemical derivative" [PubMed:11698400, PubMed:11914093, UniMod:186] +synonym: "HPG" RELATED PSI-MS-label [] +synonym: "Hydroxyphenylglyoxal arginine" RELATED UniMod-description [] +xref: DiffAvg: "132.12" +xref: DiffFormula: "C 8 H 4 O 2" +xref: DiffMono: "132.021129" +xref: Formula: "C 14 H 16 N 4 O 3" +xref: MassAvg: "288.31" +xref: MassMono: "288.122240" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00543 +name: bis(hydroxyphenylglyoxal) arginine +def: "modification from UniMod Chemical derivative" [PubMed:11698400, UniMod:187] +comment: OH-PGO and PGO react with arginine at a stoichiometry of 2:1 [UniMod]. +synonym: "2HPG" RELATED PSI-MS-label [] +synonym: "bis(hydroxphenylglyoxal) arginine" RELATED UniMod-description [] +xref: DiffAvg: "282.25" +xref: DiffFormula: "C 16 H 10 O 5" +xref: DiffMono: "282.052823" +xref: Formula: "C 22 H 22 N 4 O 6" +xref: MassAvg: "438.44" +xref: MassMono: "438.153934" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00544 +name: 6x(13)C labeled residue +def: "A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue." [PubMed:12716131, UniMod:188] +subset: PSI-MOD-slim +synonym: "13C(6) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.02" +xref: DiffFormula: "(12)C -6 (13)C 6" +xref: DiffMono: "6.020129" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue + +[Term] +id: MOD:00545 +name: deuterated dimethyl labeling (D) +def: "OBSOLETE because redundant with MOD:00927. Remap to MOD:00927." [PubMed:14670044] +xref: DiffAvg: "34.07" +xref: DiffFormula: "C 2 (1)H -2 (2)H 6" +xref: DiffMono: "34.068961" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_obsolete: true + +[Term] +id: MOD:00546 +name: (18)O label at both C-terminal oxygens +def: "A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group." [OMSSA:88, PubMed:11467524, UniMod:193] +subset: PSI-MOD-slim +synonym: "ctermpepdio18" EXACT OMSSA-label [] +synonym: "Label:18O(2)" RELATED PSI-MS-label [] +synonym: "O18 label at both C-terminal oxygens" RELATED UniMod-description [] +xref: DiffAvg: "4.01" +xref: DiffFormula: "(16)O -2 (18)O 2" +xref: DiffMono: "4.008493" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00847 ! (18)O disubstituted residue + +[Term] +id: MOD:00547 +name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate +def: "modification from UniMod Chemical derivative" [PubMed:14997490, UniMod:194] +synonym: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate" RELATED UniMod-description [] +synonym: "AccQTag" RELATED PSI-MS-label [] +xref: DiffAvg: "170.17" +xref: DiffFormula: "C 10 H 6 N 2 O 1" +xref: DiffMono: "170.048013" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00548 +name: APTA-d0 +def: "modification from UniMod Chemical derivative" [PubMed:15283597, UniMod:195] +comment: Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride [JSG]. +synonym: "APTA-d0" RELATED UniMod-description [] +synonym: "QAT" RELATED PSI-MS-label [] +xref: DiffAvg: "171.26" +xref: DiffFormula: "C 9 H 19 N 2 O 1" +xref: DiffMono: "171.149738" +xref: Formula: "C 12 H 24 N 3 O 2 S 1" +xref: MassAvg: "274.40" +xref: MassMono: "274.158923" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00549 +name: APTA d3 +def: "modification from UniMod Isotopic label" [PubMed:15283597, UniMod:196] +comment: Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG]. +synonym: "(3-acrylamidopropyl)trimethylammonium" RELATED UniMod-description [] +synonym: "APTA d3" RELATED UniMod-description [] +synonym: "QAT:2H(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "174.17" +xref: DiffFormula: "C 9 (1)H 16 (2)H 3 N 2 O 1" +xref: DiffMono: "174.168568" +xref: Formula: "C 12 (1)H 21 (2)H 3 N 3 O 2 S 1" +xref: MassAvg: "277.18" +xref: MassMono: "277.177753" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00550 +name: EAPTA d0 +def: "modification from UniMod Chemical derivative" [UniMod:197] +synonym: "EAPTA d0" RELATED UniMod-description [] +synonym: "EQAT" RELATED PSI-MS-label [] +xref: DiffAvg: "184.28" +xref: DiffFormula: "C 10 H 20 N 2 O 1" +xref: DiffMono: "184.157563" +xref: Formula: "C 13 H 25 N 3 O 2 S 1" +xref: MassAvg: "287.42" +xref: MassMono: "287.166748" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00551 +name: EAPTA d5 +def: "modification from UniMod Isotopic label" [UniMod:198] +synonym: "EAPTA d5" RELATED UniMod-description [] +synonym: "EQAT:2H(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "189.19" +xref: DiffFormula: "C 10 (1)H 15 (2)H 5 N 2 O 1" +xref: DiffMono: "189.188947" +xref: Formula: "C 13 (1)H 20 (2)H 5 N 3 O 2 S 1" +xref: MassAvg: "292.20" +xref: MassMono: "292.198132" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00552 +name: 4x(2)H labeled dimethylated residue +def: "A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue." [PubMed:14670044, UniMod:199] +comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. +subset: PSI-MOD-slim +synonym: "DiMethyl-CHD2" RELATED UniMod-description [] +synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "32.06" +xref: DiffFormula: "C 2 (2)H 4" +xref: DiffMono: "32.056407" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue + +[Term] +id: MOD:00553 +name: 1,2-ethanedithiol modified residue +def: "A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group." [DeltaMass:0, PubMed:11507762, UniMod:200] +comment: From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine. +synonym: "1,2-ethanedithiol (EDT)" EXACT DeltaMass-label [] +synonym: "EDT" RELATED UniMod-description [] +synonym: "Ethanedithiol" RELATED PSI-MS-label [] +xref: DiffAvg: "76.18" +xref: DiffFormula: "C 2 H 4 O -1 S 2" +xref: DiffMono: "75.980528" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00554 +name: APTA-d0 with no neutral loss +def: "OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative" [UniMod:202] +xref: DiffAvg: "170.26" +xref: DiffFormula: "C 9 H 18 N 2 O 1" +xref: DiffMono: "170.141913" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00555 +name: APTA-d0 with quaternary amine loss +def: "OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative" [UniMod:203] +xref: DiffAvg: "170.26" +xref: DiffFormula: "C 9 H 18 N 2 O 1" +xref: DiffMono: "170.141913" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00556 +name: acrolein addition +94 +def: "modification from UniMod Other" [UniMod:205] +synonym: "Acrolein addition +94" RELATED UniMod-description [] +synonym: "Delta:H(6)C(6)O(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "94.11" +xref: DiffFormula: "C 6 H 6 O 1" +xref: DiffMono: "94.041865" +xref: Formula: "C 12 H 18 N 2 O 2" +xref: MassAvg: "222.29" +xref: MassMono: "222.136828" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00557 +name: acrolein addition +56 +def: "modification from UniMod Other" [PubMed:10825247, PubMed:15541752, UniMod:206] +synonym: "Acrolein addition +56" RELATED UniMod-description [] +synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00558 +name: acrolein addition +38 +def: "modification from UniMod Other" [UniMod:207] +synonym: "Acrolein addition +38" RELATED UniMod-description [] +synonym: "Delta:H(2)C(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "38.05" +xref: DiffFormula: "C 3 H 2" +xref: DiffMono: "38.015650" +xref: Formula: "C 9 H 14 N 2 O 1" +xref: MassAvg: "166.22" +xref: MassMono: "166.110613" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00559 +name: acrolein addition +76 +def: "modification from UniMod Other" [UniMod:208] +synonym: "Acrolein addition +76" RELATED UniMod-description [] +synonym: "Delta:H(4)C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "76.10" +xref: DiffFormula: "C 6 H 4" +xref: DiffMono: "76.031300" +xref: Formula: "C 12 H 16 N 2 O 1" +xref: MassAvg: "204.27" +xref: MassMono: "204.126263" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00560 +name: acrolein addition +112 +def: "modification from UniMod Other" [UniMod:209] +synonym: "Acrolein addition +112" RELATED UniMod-description [] +synonym: "Delta:H(8)C(6)O(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "112.13" +xref: DiffFormula: "C 6 H 8 O 2" +xref: DiffMono: "112.052429" +xref: Formula: "C 12 H 20 N 2 O 3" +xref: MassAvg: "240.30" +xref: MassMono: "240.147393" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00561 +name: N-ethyl iodoacetamide-d0 +def: "modification from UniMod Isotopic label" [PubMed:12766232, UniMod:211] +synonym: "N-ethyl iodoacetamide-d0" RELATED UniMod-description [] +synonym: "NEIAA" RELATED PSI-MS-label [] +xref: DiffAvg: "85.11" +xref: DiffFormula: "C 4 H 7 N 1 O 1" +xref: DiffMono: "85.052764" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00562 +name: N-ethyl iodoacetamide-d5 +def: "modification from UniMod Isotopic label" [PubMed:12766232, UniMod:212] +synonym: "N-ethyl iodoacetamide-d5" RELATED UniMod-description [] +synonym: "NEIAA:2H(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "90.08" +xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1" +xref: DiffMono: "90.084148" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00563 +name: N-acetylaminogalactosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "GalNAcRes" EXACT PSI-MOD-label [] +synonym: "HexNAc" RELATED PSI-MS-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00734 ! N-acetylaminogalactosylated +is_a: MOD:01673 ! N-acetylaminohexosylated residue + +[Term] +id: MOD:00564 +name: Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry +def: "Modification from UniMod Isotopic label. The UniMod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497." [UniMod:214, URL:http\://docs.appliedbiosystems.com/pebiodocs/04351918.pdf] +synonym: "iTRAQ4plex" RELATED UniMod-interim [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 O 1" +xref: DiffMono: "144.102062" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00565 +name: deglycosylated asparagine +def: "modification from UniMod N-linked glycosylation" [UniMod:7#N] +comment: Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG]. +synonym: "Deamidated" RELATED UniMod-interim [] +synonym: "Deamidation" RELATED UniMod-description [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00566 +name: label cysteine with IGBP reagent +def: "modification from UniMod Chemical derivative" [UniMod:243] +comment: "IDBEST tag for quantitation, http://www.targetdiscovery.com/index.php?topic=prod.idbe" +synonym: "IGBP" RELATED PSI-MS-label [] +synonym: "Light IDBEST tag for quantitation" RELATED UniMod-description [] +xref: DiffAvg: "297.15" +xref: DiffFormula: "Br 1 C 12 H 13 N 2 O 2" +xref: DiffMono: "296.016040" +xref: Formula: "Br 1 C 15 H 18 N 3 O 3 S 1" +xref: MassAvg: "400.29" +xref: MassMono: "399.025225" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00567 +name: histidine oxidation to asparagine +def: "OBSOLETE because UniMod entry 244 is redundant with UniMod 348. Remap to MOD:00775." [ChEBI:29956, PubMed:15736973, PubMed:5681232, PubMed:6692818, PubMed:9789001, RESID:AA0003, UniMod:244] +xref: DiffAvg: "-23.04" +xref: DiffFormula: "C -2 H -1 N -1 O 1" +xref: DiffMono: "-23.015984" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00568 +name: histidine oxidation to aspartic acid +def: "OBSOLETE because UniMod entry 245 is redundant with UniMod 349. Remap to MOD:00776" [PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, UniMod:245] +xref: DiffAvg: "-22.05" +xref: DiffFormula: "C -2 H -2 N -2 O 2" +xref: DiffMono: "-22.031969" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00569 +name: residues isobaric at a resolution below 0.000001 Da +def: "Natural or modified residues that are isobaric at a resolution below 0.000001 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da + +[Term] +id: MOD:00570 +name: residues isobaric at 71.037114 Da +def: "Natural or modified residues with a mass of 71.037114 Da." [PubMed:18688235] +is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da +is_a: MOD:00769 ! residues isobaric at 71.0-71.1 Da + +[Term] +id: MOD:00571 +name: 2-pyrrolidone-5-carboxylic acid (Pro) +def: "A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid." [OMSSA:111, PubMed:9252331, UniMod:359] +comment: The review article PubMed:9252331 does not provide an original citation for this modification [JSG]. +synonym: "Pro->pyro-Glu" RELATED PSI-MS-label [] +synonym: "PyrGlu(Pro)" EXACT PSI-MOD-label [] +synonym: "Pyroglutamic" RELATED UniMod-interim [] +synonym: "pyroglutamicp" EXACT OMSSA-label [] +xref: DiffAvg: "13.98" +xref: DiffFormula: "H -2 O 1" +xref: DiffMono: "13.979265" +xref: Formula: "C 5 H 6 N 1 O 2" +xref: MassAvg: "112.11" +xref: MassMono: "112.039853" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid + +[Term] +id: MOD:00572 +name: oxidized arginine biotinylated with biotin hydrazide +def: "modification from UniMod Chemical derivative" [PubMed:15174056, PubMed:15828771, UniMod:343] +synonym: "Argbiotinhydrazide" RELATED UniMod-interim [] +synonym: "oxidized Arginine biotinylated with biotin hydrazide" RELATED UniMod-description [] +xref: DiffAvg: "199.27" +xref: DiffFormula: "C 9 H 13 N 1 O 2 S 1" +xref: DiffMono: "199.066700" +xref: Formula: "C 15 H 25 N 5 O 3 S 1" +xref: MassAvg: "355.46" +xref: MassMono: "355.167811" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00573 +name: oxidized lysine biotinylated with biotin hydrazide +def: "modification from UniMod Chemical derivative" [PubMed:15174056, UniMod:353] +comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" +synonym: "Lysbiotinhydrazide" RELATED UniMod-interim [] +synonym: "oxidized Lysine biotinylated with biotin hydrazide" RELATED UniMod-description [] +xref: DiffAvg: "241.31" +xref: DiffFormula: "C 10 H 15 N 3 O 2 S 1" +xref: DiffMono: "241.088498" +xref: Formula: "C 16 H 27 N 5 O 3 S 1" +xref: MassAvg: "369.48" +xref: MassMono: "369.183461" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00574 +name: oxidized proline biotinylated with biotin hydrazide +def: "modification from UniMod Chemical derivative" [PubMed:15174056, UniMod:357] +comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" +synonym: "oxidized proline biotinylated with biotin hydrazide" RELATED UniMod-description [] +synonym: "probiotinhydrazide" RELATED UniMod-interim [] +xref: DiffAvg: "258.34" +xref: DiffFormula: "C 10 H 18 N 4 O 2 S 1" +xref: DiffMono: "258.115047" +xref: Formula: "C 15 H 25 N 5 O 3 S 1" +xref: MassAvg: "355.46" +xref: MassMono: "355.167811" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00575 +name: oxidized threonine biotinylated with biotin hydrazide +def: "modification from UniMod Chemical derivative" [PubMed:15174056, UniMod:361] +comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" +synonym: "oxidized Threonine biotinylated with biotin hydrazide" RELATED UniMod-description [] +synonym: "Thrbiotinhydrazide" RELATED UniMod-interim [] +xref: DiffAvg: "240.32" +xref: DiffFormula: "C 10 H 16 N 4 O 1 S 1" +xref: DiffMono: "240.104482" +xref: Formula: "C 14 H 23 N 5 O 3 S 1" +xref: MassAvg: "341.43" +xref: MassMono: "341.152161" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00576 +name: crotonaldehyde +def: "modification from UniMod Other" [PubMed:11283024, UniMod:253] +synonym: "Crotonaldehyde" RELATED PSI-MS-label [] +synonym: "Crotonaldehyde" RELATED UniMod-description [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00577 +name: acetaldehyde +26 +def: "modification from UniMod Other" [PubMed:7744761, UniMod:254] +synonym: "Acetaldehyde +26" RELATED UniMod-description [] +synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "26.04" +xref: DiffFormula: "C 2 H 2" +xref: DiffMono: "26.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00578 +name: acetaldehyde +28 +def: "modification from UniMod Other" [UniMod:255] +synonym: "Acetaldehyde +28" RELATED UniMod-description [] +synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00579 +name: propionaldehyde +40 +def: "modification from UniMod Other" [UniMod:256] +synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label [] +synonym: "Propionaldehyde +40" RELATED UniMod-description [] +xref: DiffAvg: "40.06" +xref: DiffFormula: "C 3 H 4" +xref: DiffMono: "40.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00580 +name: propionaldehyde +42 +def: "OBSOLETE because entry removed from UniMod. Remap potentially to MOD:00579 propionaldehyde +40" [UniMod:257] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6" +xref: DiffMono: "42.046950" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00581 +name: (18)O monosubstituted residue +def: "A protein modification that effectively substitutes one (18)O atom for one (16)O atom." [OMSSA:87, PubMed:11467524, UniMod:258] +subset: PSI-MOD-slim +synonym: "ctermpepo18" EXACT OMSSA-label [] +synonym: "Label:18O(1)" RELATED PSI-MS-label [] +synonym: "O18 Labeling" RELATED UniMod-description [] +xref: DiffAvg: "2.00" +xref: DiffFormula: "(16)O -1 (18)O 1" +xref: DiffMono: "2.004246" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00845 ! (18)O substituted residue + +[Term] +id: MOD:00582 +name: 6x(13)C,2x(15)N labeled L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine." [OMSSA:181, PubMed:12716131, UniMod:259] +synonym: "13C(6) 15N(2) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)15N(2)" RELATED PSI-MS-label [] +synonym: "lys-13C615N2" EXACT OMSSA-label [] +xref: DiffAvg: "8.01" +xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -2 (15)N 2" +xref: DiffMono: "8.014199" +xref: Formula: "(13)C 6 H 12 (15)N 2 O 1" +xref: MassAvg: "136.11" +xref: MassMono: "136.109162" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00843 ! (15)N labeled residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00583 +name: thiophosphorylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate')." [PubMed:12110917, UniMod:260] +synonym: "Thiophospho" RELATED PSI-MS-label [] +synonym: "Thiophosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "96.04" +xref: DiffFormula: "H 1 O 2 P 1 S 1" +xref: DiffMono: "95.943487" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:00584 +name: 4-sulfophenyl isothiocyanate derivatized residue +def: "A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate." [PubMed:14689565, PubMed:14745769, PubMed:16526082, UniMod:261] +synonym: "4-sulfophenyl isothiocyanate" RELATED UniMod-description [] +synonym: "SPITC" RELATED PSI-MS-label [] +xref: DiffAvg: "215.24" +xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" +xref: DiffMono: "214.971085" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00841 ! isothiocyanate reagent derivatized residue + +[Term] +id: MOD:00585 +name: deuterium trisubstituted residue +def: "A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms." [UniMod:262] +synonym: "D(H)3Res" EXACT PSI-MOD-label [] +synonym: "Label:2H(3)" RELATED PSI-MS-label [] +synonym: "Trideuteration" RELATED UniMod-description [] +xref: DiffAvg: "3.02" +xref: DiffFormula: "(1)H -3 (2)H 3" +xref: DiffMono: "3.018830" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00786 ! deuterium substituted residue + +[Term] +id: MOD:00586 +name: phosphorylation to pyridyl thiol +def: "modification from UniMod Chemical derivative" [UniMod:264] +synonym: "PET" RELATED PSI-MS-label [] +synonym: "phosphorylation to pyridyl thiol" RELATED UniMod-description [] +xref: DiffAvg: "121.20" +xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1" +xref: DiffMono: "121.035006" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00587 +name: 6x(13)C,4x(15)N labeled L-arginine +def: "A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine." [OMSSA:137, PubMed:12716131, UniMod:267] +subset: PSI-MOD-slim +synonym: "13C(6) 15N(4) Silac label" RELATED UniMod-description [] +synonym: "arg-13c6-15n4" EXACT OMSSA-label [] +synonym: "Label:13C(6)15N(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "10.01" +xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -4 (15)N 4" +xref: DiffMono: "10.008269" +xref: Formula: "(13)C 6 H 12 (15)N 4 O 1" +xref: MassAvg: "166.11" +xref: MassMono: "166.109380" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00843 ! (15)N labeled residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00588 +name: 5x(13)C,1x(15)N labeled L-valine +def: "A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine." [PubMed:12771378, UniMod:268#V] +synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.01" +xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" +xref: DiffMono: "6.013809" +xref: Formula: "(13)C 5 H 9 (15)N 1 O 1" +xref: MassAvg: "105.08" +xref: MassMono: "105.082223" +xref: Origin: "V" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue + +[Term] +id: MOD:00589 +name: 1x(13)C,1x(15)N labeled L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine." [PubMed:12771378, UniMod:269] +synonym: "13C(9) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(9)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "10.03" +xref: DiffFormula: "(12)C -9 (13)C 9 (14)N -1 (15)N 1" +xref: DiffMono: "10.027228" +xref: Formula: "(13)C 9 H 9 (15)N 1 O 1" +xref: MassAvg: "157.10" +xref: MassMono: "157.095642" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00843 ! (15)N labeled residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:00590 +name: nucleophilic addtion to cytopiloyne +def: "modification from UniMod Chemical derivative" [PubMed:15549660, UniMod:270] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00591 +name: nucleophilic addition to cytopiloyne+H2O +def: "modification from UniMod Chemical derivative" [PubMed:15549660, UniMod:271] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00592 +name: sulfonation of N-terminal +def: "modification from UniMod Chemical derivative" [PubMed:12705581, PubMed:15732931, PubMed:16046801, UniMod:272] +synonym: "CAF" RELATED PSI-MS-label [] +synonym: "sulfonation of N-terminus" RELATED UniMod-description [] +xref: DiffAvg: "136.12" +xref: DiffFormula: "C 3 H 4 O 4 S 1" +xref: DiffMono: "135.983030" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00593 +name: covalent modification of lysine by omega-maleimido alkanoyl N-hydroxysuccinimido esters +def: "modification from UniMod Chemical derivative" [UniMod:273] +comment: J. Prot. Chem. 2, 263-277, 1983 +synonym: "covalent modification of lysine by cross-linking reagent" RELATED UniMod-description [] +synonym: "Xlink:SSD" RELATED PSI-MS-label [] +xref: DiffAvg: "253.25" +xref: DiffFormula: "C 12 H 15 N 1 O 5" +xref: DiffMono: "253.095023" +xref: Formula: "C 18 H 27 N 3 O 6" +xref: MassAvg: "381.43" +xref: MassMono: "381.189986" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00594 +name: residues isobaric at 113.047678 Da +def: "Natural or modified resiues with a mass of 113.047678 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da +is_a: MOD:00624 ! residues isobaric at 113.0-113.1 Da + +[Term] +id: MOD:00595 +name: mannosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond" [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ManRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00434 ! hexosylated residue +is_a: MOD:00727 ! mannosylated + +[Term] +id: MOD:00596 +name: 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue +def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS." [DeltaMass:235, PubMed:8597590, UniMod:276] +comment: From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution. +synonym: "AEBS" RELATED PSI-MS-label [] +synonym: "AEBSF" EXACT DeltaMass-label [] +synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] +xref: DiffAvg: "183.23" +xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" +xref: DiffMono: "183.035400" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue + +[Term] +id: MOD:00597 +name: methyl methanethiosulfonate +def: "OBSOLETE because UniMod entry 277 redundant with UniMod 39. Remap to MOD:00110." [UniMod:277] +xref: DiffAvg: "46.09" +xref: DiffFormula: "C 1 H 2 S 1" +xref: DiffMono: "45.987721" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00598 +name: S-(2-hydroxyethyl)cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine" [PubMed:15351294, UniMod:278] +comment: This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG]. +subset: PSI-MOD-slim +synonym: "Ethanolation of Cys" RELATED UniMod-description [] +synonym: "Ethanolyl" RELATED PSI-MS-label [] +xref: DiffAvg: "44.05" +xref: DiffFormula: "C 2 H 4 O 1" +xref: DiffMono: "44.026215" +xref: Formula: "C 5 H 9 N 1 O 2 S 1" +xref: MassAvg: "147.19" +xref: MassMono: "147.035400" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00599 +name: monomethylated residue +def: "A protein modification that effectively replaces one hydrogen atom with one methyl group." [PubMed:11875433, UniMod:34] +subset: PSI-MOD-slim +synonym: "Me1Res" EXACT PSI-MOD-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2" +xref: DiffMono: "14.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00600 +name: L-glutamic acid 5-ethyl ester +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester." [DeltaMass:0, PubMed:9629898, UniMod:280#E] +comment: From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG]. +synonym: "Ethyl" EXACT DeltaMass-label [] +synonym: "Ethyl" RELATED PSI-MS-label [] +synonym: "Ethylation" RELATED UniMod-description [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "C 7 H 11 N 1 O 3" +xref: MassAvg: "157.17" +xref: MassMono: "157.073893" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01339 ! ethylated residue + +[Term] +id: MOD:00601 +name: cyclized residue +def: "A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "CycRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00602 +name: N-methylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NMeRes" EXACT PSI-MOD-label [] +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00603 +name: N-ethylation +def: "OBSOLETE because UniMod entry 283 is redundant with UniMod 280. Remap to MOD:00600" [UniMod:283] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_obsolete: true + +[Term] +id: MOD:00604 +name: 2x(2)H monomethylated L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine." [PubMed:15525938, UniMod:284] +synonym: "Deuterium Methylation of Lysine" RELATED UniMod-description [] +synonym: "Methyl:2H(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "16.03" +xref: DiffFormula: "C 1 (2)H 2" +xref: DiffMono: "16.028204" +xref: Formula: "C 7 (1)H 12 (2)H 2 N 2 O 1" +xref: MassAvg: "144.12" +xref: MassMono: "144.123167" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00912 ! modified L-lysine residue +relationship: derives_from MOD:00085 ! N6-methyl-L-lysine + +[Term] +id: MOD:00605 +name: Sulfanilic Acid (SA), light C12 +def: "modification from UniMod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation" [UniMod:285] +synonym: "Light Sulfanilic Acid (SA) C12" RELATED UniMod-description [] +synonym: "SulfanilicAcid" RELATED PSI-MS-label [] +xref: DiffAvg: "155.17" +xref: DiffFormula: "C 6 H 5 N 1 O 2 S 1" +xref: DiffMono: "155.004099" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00606 +name: Sulfanilic Acid (SA), heavy C13 +def: "modification from UniMod Chemical derivative" [PubMed:9254591, UniMod:286] +synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED UniMod-description [] +synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "161.02" +xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1" +xref: DiffMono: "161.024228" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00607 +name: dioxoindolealanine lactone +def: "modification from UniMod Chemical derivative" [PubMed:7949339, UniMod:288] +comment: UniMod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG]. +synonym: "Trp->Oxolactone" RELATED PSI-MS-label [] +synonym: "Tryptophan oxidation to oxolactone" RELATED UniMod-description [] +xref: DiffAvg: "30.99" +xref: DiffFormula: "H -1 O 2" +xref: DiffMono: "30.982004" +xref: Formula: "C 11 H 9 N 2 O 3" +xref: MassAvg: "217.20" +xref: MassMono: "217.061317" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00608 +name: biotin polyethyleneoxide amine +def: "modification from UniMod Chemical derivative" [UniMod:289] +synonym: "Biotin polyethyleneoxide amine" RELATED UniMod-description [] +synonym: "Biotin-PEO-Amine" RELATED UniMod-interim [] +xref: DiffAvg: "356.49" +xref: DiffFormula: "C 16 H 28 N 4 O 3 S 1" +xref: DiffMono: "356.188212" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00609 +name: Pierce EZ-Link Biotin-HPDP +def: "modification from UniMod Chemical derivative" [UniMod:290] +synonym: "Biotin-HPDP" RELATED UniMod-interim [] +synonym: "Pierce EZ-Link Biotin-HPDP" RELATED UniMod-description [] +xref: DiffAvg: "428.61" +xref: DiffFormula: "C 19 H 32 N 4 O 3 S 2" +xref: DiffMono: "428.191583" +xref: Formula: "C 22 H 37 N 5 O 4 S 3" +xref: MassAvg: "531.75" +xref: MassMono: "531.200768" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00610 +name: cysteinyl mercury +def: "modification from UniMod Chemical derivative" [PubMed:10695144, UniMod:291] +synonym: "Delta:Hg(1)" RELATED PSI-MS-label [] +synonym: "Mercury Mercaptan" RELATED UniMod-description [] +xref: DiffAvg: "200.59" +xref: DiffFormula: "Hg 1" +xref: DiffMono: "201.970643" +xref: Formula: "C 3 H 5 Hg 1 N 1 O 1 S 1" +xref: MassAvg: "303.73" +xref: MassMono: "304.979828" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01075 ! mercury containing modified residue + +[Term] +id: MOD:00611 +name: iodouridine monophosphate derivatized residue +def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with a residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292] +synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] +synonym: "IodoU-AMP" RELATED PSI-MS-label [] +xref: DiffAvg: "322.17" +xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" +xref: DiffMono: "322.020217" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00612 +name: 3-(carboxamidomethylthio)propanoylated residue +def: "A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide." [PubMed:15121203, UniMod:293] +synonym: "3-(carbamidomethylthio)propanoyl" RELATED UniMod-description [] +synonym: "CAMthiopropanoyl" RELATED PSI-MS-label [] +xref: DiffAvg: "145.18" +xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1" +xref: DiffMono: "145.019749" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00613 +name: biotinoyl-iodoacetyl-ethylenediamine +def: "modification from UniMod Chemical derivative" [PubMed:10906242, UniMod:294] +synonym: "biotinoyl-iodoacetyl-ethylenediamine" RELATED UniMod-description [] +synonym: "IED-Biotin" RELATED PSI-MS-label [] +xref: DiffAvg: "326.42" +xref: DiffFormula: "C 14 H 22 N 4 O 3 S 1" +xref: DiffMono: "326.141262" +xref: Formula: "C 17 H 27 N 5 O 4 S 2" +xref: MassAvg: "429.55" +xref: MassMono: "429.150446" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00614 +name: fucosylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond." [PubMed:11344537, PubMed:15189151, UniMod:295] +subset: PSI-MOD-slim +synonym: "dHex" RELATED PSI-MS-label [] +synonym: "Fuc" EXACT PSI-MOD-label [] +synonym: "Fucose" RELATED UniMod-description [] +xref: DiffAvg: "146.14" +xref: DiffFormula: "C 6 H 10 O 4" +xref: DiffMono: "146.057909" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00736 ! deoxyhexosylated + +[Term] +id: MOD:00615 +name: 4-sulfophenyl isothiocyante modification to N-term R +def: "OBSOLETE because entry UniMod:261 site N-term R was abandoned. Remap to MOD:00584" [PubMed:14689565, UniMod:261] +xref: DiffAvg: "215.24" +xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" +xref: DiffMono: "214.971085" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_obsolete: true + +[Term] +id: MOD:00616 +name: residues isobaric at a resolution below 0.1 Da +def: "Natural or modified residues that are isobaric at a resolution below 0.1 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00538 ! protein modification categorized by isobaric sets + +[Term] +id: MOD:00617 +name: 3x(2)H residue methyl ester +def: "A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester." [OMSSA:21, UniMod:298] +synonym: "ctermpeptrideuteromethyl" EXACT OMSSA-label [] +synonym: "deuterated methyl ester" RELATED UniMod-description [] +synonym: "Methyl:2H(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "17.03" +xref: DiffFormula: "C 1 (1)H -1 (2)H 3" +xref: DiffMono: "17.034480" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "C-term" +is_a: MOD:00839 ! (2)H deuterium labeled residue + +[Term] +id: MOD:00618 +name: tryptophan carboxylation +def: "modification from UniMod Chemical derivative" [UniMod:299#W] +comment: There is no literature citation for this UniMod entry [JSG]. +synonym: "Carboxy" RELATED UniMod-interim [] +synonym: "Carboxylation" RELATED UniMod-description [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "C 12 H 10 N 2 O 3" +xref: MassAvg: "230.22" +xref: MassMono: "230.069142" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:00619 +name: hydroxylethanone +def: "OBSOLETE because entry 300 is redundant with UniMod 6 remap to MOD:01328" [UniMod:300] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00620 +name: cysteine monobromobimane derivative +def: "modification from UniMod Chemical derivative" [PubMed:7856876, UniMod:301] +comment: 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione, C 10 H 11 Br 1 N 2 O 2. +synonym: "Bromobimane" RELATED PSI-MS-label [] +synonym: "Monobromobimane derivative" RELATED UniMod-description [] +xref: DiffAvg: "190.20" +xref: DiffFormula: "C 10 H 10 N 2 O 2" +xref: DiffMono: "190.074228" +xref: Formula: "C 13 H 15 N 3 O 3 S 1" +xref: MassAvg: "293.34" +xref: MassMono: "293.083412" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00621 +name: menadione quinone derivative +def: "modification from UniMod Chemical derivative" [PubMed:15939799, UniMod:302] +synonym: "Menadione" RELATED UniMod-interim [] +synonym: "Menadione quinone derivative" RELATED UniMod-description [] +xref: DiffAvg: "170.17" +xref: DiffFormula: "C 11 H 6 O 2" +xref: DiffMono: "170.036779" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00622 +name: cysteine mercaptoethanol +def: "modification from UniMod Chemical derivative" [DeltaMass:80, PubMed:12442261, UniMod:303] +comment: From DeltaMass: Average Mass: 76 Average Mass Change:76 PubMed:8019414. +synonym: "Beta mercaptoethanol adduct" EXACT DeltaMass-label [] +synonym: "Cysteine mercaptoethanol" RELATED UniMod-description [] +synonym: "DeStreak" RELATED PSI-MS-label [] +xref: DiffAvg: "76.11" +xref: DiffFormula: "C 2 H 4 O 1 S 1" +xref: DiffMono: "75.998286" +xref: Formula: "C 5 H 9 N 1 O 2 S 2" +xref: MassAvg: "179.25" +xref: MassMono: "179.007471" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00623 +name: fucosylated biantennary (-2 galactose) +def: "modification from UniMod N-linked glycosylation" [UniMod:305] +synonym: "dHex(1)Hex(3)HexNAc(4)" RELATED PSI-MS-label [] +synonym: "Fucosylated biantennary (-2 galactose)" RELATED UniMod-description [] +xref: DiffAvg: "1443.33" +xref: DiffFormula: "C 56 H 90 N 4 O 39" +xref: DiffMono: "1442.518219" +xref: Formula: "C 60 H 96 N 6 O 41" +xref: MassAvg: "1557.43" +xref: MassMono: "1556.561147" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00624 +name: residues isobaric at 113.0-113.1 Da +def: "Natural or modified residues with a mass of 113.0-113.1 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da + +[Term] +id: MOD:00625 +name: N-methylmaleimide derivatized residue +def: "modification from UniMod Chemical derivative" [UniMod:314] +synonym: "Nmethylmaleimide" RELATED PSI-MS-label [] +synonym: "Nmethylmaleimide" RELATED UniMod-description [] +xref: DiffAvg: "111.10" +xref: DiffFormula: "C 5 H 5 N 1 O 2" +xref: DiffMono: "111.032028" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00626 +name: fluorescein-5-thiosemicarbazide +def: "modification from UniMod Chemical derivative" [PubMed:2883911, UniMod:478] +synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] +synonym: "FTC" RELATED PSI-MS-label [] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00627 +name: 2,5-dimethylpyrrole lysine from 2,5-hexanedione adduct +def: "modification from UniMod Chemical derivative" [UniMod:316] +comment: There is no citation for this UniMod entry. Add PubMed:7981420, correct spelling [JSG]. +synonym: "(2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2,5-dimethypyrrole" RELATED UniMod-description [] +synonym: "6-(2,5-dimethylpyrrolidin-1-yl)norleucine" EXACT PSI-MOD-alternate [] +synonym: "DimethylpyrroleAdduct" RELATED PSI-MS-label [] +xref: DiffAvg: "78.11" +xref: DiffFormula: "C 6 H 6" +xref: DiffMono: "78.046950" +xref: Formula: "C 12 H 18 N 2 O 1" +xref: MassAvg: "206.29" +xref: MassMono: "206.141913" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00628 +name: Hex2 +def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds" [PubMed:18688235] +xref: DiffAvg: "324.28" +xref: DiffFormula: "C 12 H 20 O 10" +xref: DiffMono: "324.105647" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:00629 +name: MDA adduct +62 +def: "modification from UniMod Chemical derivative" [UniMod:318] +comment: Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt]. +synonym: "Delta:H(2)C(5)" RELATED PSI-MS-label [] +synonym: "MDA adduct +62" RELATED UniMod-description [] +xref: DiffAvg: "62.07" +xref: DiffFormula: "C 5 H 2" +xref: DiffMono: "62.015650" +xref: Formula: "C 11 H 14 N 2 O 1" +xref: MassAvg: "190.25" +xref: MassMono: "190.110613" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00630 +name: C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. +def: "modification from UniMod Chemical derivative" [PubMed:9328283, UniMod:319] +comment: This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG] +synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] +synonym: "MDA adduct +54" RELATED UniMod-description [] +xref: DiffAvg: "54.05" +xref: DiffFormula: "C 3 H 2 O 1" +xref: DiffMono: "54.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00631 +name: hydrolyzed N-ethylmaleimide adduct +def: "modification from UniMod Chemical derivative" [UniMod:320] +comment: N-ethylmaeimide adduct + H20 (a mixture of isobaric products) [JSG]. +synonym: "Nethylmaleimide+water" RELATED PSI-MS-label [] +synonym: "Nethylmaleimidehydrolysis" RELATED UniMod-description [] +xref: DiffAvg: "143.14" +xref: DiffFormula: "C 6 H 9 N 1 O 3" +xref: DiffMono: "143.058243" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00632 +name: N-succinimide +def: "OBSOLETE because this chemical derivative modification from UniMod 321 is deprecated." [UniMod:321] +xref: DiffAvg: "-17.01" +xref: DiffFormula: "H -1 O -1" +xref: DiffMono: "-17.002740" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00633 +name: bis-N-I-sulfonerahodamine +def: "modification from UniMod Chemical derivative" [UniMod:323] +comment: Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [UniMod]. +synonym: "bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine" EXACT PSI-MOD-alternate [] +synonym: "bis-N-I-sulfonerahodamine" RELATED UniMod-description [] +synonym: "Xlink:B10621" RELATED PSI-MS-label [] +xref: DiffAvg: "713.57" +xref: DiffFormula: "C 31 H 30 I 1 N 4 O 6 S 1" +xref: DiffMono: "713.093078" +xref: Formula: "C 34 H 35 I 1 N 5 O 7 S 2" +xref: MassAvg: "816.71" +xref: MassMono: "816.102263" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00634 +name: dimethyl 3,3'-dithiobispropionimidate +def: "modification from UniMod Chemical derivative" [PubMed:770170, UniMod:324] +comment: Pierce reagent, needs sites for N, Q, R, K, and N-term [JSG]. +synonym: "dimethyl 3,3'-dithiobispropionimidate" RELATED UniMod-description [] +synonym: "DTBP" RELATED UniMod-interim [] +xref: DiffAvg: "123.60" +xref: DiffFormula: "C 3 Cl 1 H 6 N 1 S 1" +xref: DiffMono: "122.990948" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00635 +name: 10-fluoroethoxyphosphinyl-N-(biotinamidopentyl)decanamide +def: "modification from UniMod Chemical derivative" [PubMed:10611275, UniMod:325] +synonym: "10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide" RELATED UniMod-description [] +synonym: "FP-Biotin" RELATED UniMod-interim [] +xref: DiffAvg: "572.75" +xref: DiffFormula: "C 27 H 49 N 4 O 5 P 1 S 1" +xref: DiffMono: "572.316128" +xref: Formula: "C 30 H 54 N 5 O 7 P 1 S 1" +xref: MassAvg: "659.82" +xref: MassMono: "659.348157" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00636 +name: S-ethylcysteine (Ser) +def: "A protein modification that effectively converts an L-serine residue to S-ethylcysteine." [UniMod:327] +comment: Modification from UniMod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine. +synonym: "Delta:H(4)C(2)O(-1)S(1)" RELATED PSI-MS-label [] +synonym: "S-Ethylcystine from Serine" RELATED UniMod-description [] +xref: DiffAvg: "44.11" +xref: DiffFormula: "C 2 H 4 O -1 S 1" +xref: DiffMono: "44.008457" +xref: Formula: "C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "131.19" +xref: MassMono: "131.040485" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00637 +name: 1x(13)C,3x(2)H labeled monomethylated L-arginine +def: "A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine." [UniMod:329] +synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label [] +synonym: "monomethylated arginine" RELATED UniMod-description [] +xref: DiffAvg: "18.04" +xref: DiffFormula: "(13)C 1 (1)H -1 (2)H 3" +xref: DiffMono: "18.037835" +xref: Formula: "(12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1" +xref: MassAvg: "174.14" +xref: MassMono: "174.138946" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00902 ! modified L-arginine residue +relationship: derives_from MOD:00414 ! monomethylated L-arginine + +[Term] +id: MOD:00638 +name: 2x(13)C,6x(2)H labeled dimethylated L-arginine +def: "A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine." [PubMed:15782174, UniMod:330] +synonym: "Dimethyl:2H(6)13C(2)" RELATED PSI-MS-label [] +synonym: "dimethylated arginine" RELATED UniMod-description [] +xref: DiffAvg: "36.08" +xref: DiffFormula: "(13)C 2 (1)H -2 (2)H 6" +xref: DiffMono: "36.075670" +xref: Formula: "(12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1" +xref: MassAvg: "192.18" +xref: MassMono: "192.176781" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00902 ! modified L-arginine residue +relationship: derives_from MOD:00783 ! dimethylated L-arginine + +[Term] +id: MOD:00639 +name: thiophosphate labeled with biotin-HPDP +def: "modification from UniMod Chemical derivative" [UniMod:332] +synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] +synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] +xref: DiffAvg: "525.66" +xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" +xref: DiffMono: "525.142895" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:00640 +name: 6-N-biotinylaminohexyl isopropyl phosphorofluoridate +def: "modification from UniMod Chemical derivative" [UniMod:333] +synonym: "6-N-biotinylaminohexyl isopropyl phosphate" RELATED UniMod-description [] +synonym: "Can-FP-biotin" RELATED UniMod-interim [] +xref: DiffAvg: "467.54" +xref: DiffFormula: "C 19 F 1 H 35 N 3 O 5 P 1 S 1" +xref: DiffMono: "467.201907" +xref: Formula: "C 22 F 1 H 40 N 4 O 7 P 1 S 1" +xref: MassAvg: "554.62" +xref: MassMono: "554.233935" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00641 +name: CAMthiopropanoyl of Lys +def: "OBSOLETE because UniMod entry 334 is merged with UniMod 293. Remap to MOD:00612" [UniMod:334] +xref: DiffAvg: "146.18" +xref: DiffFormula: "C 5 H 8 N 1 O 2 S 1" +xref: DiffMono: "146.027574" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00642 +name: reduced 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:15133838, UniMod:335] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] +synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] +xref: DiffAvg: "158.24" +xref: DiffFormula: "C 9 H 18 O 2" +xref: DiffMono: "158.130680" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:01155 ! lipoconjugated residue +relationship: derives_from MOD:00446 ! 4-hydroxynonenal adduct + +[Term] +id: MOD:00643 +name: methylamine Michael addition derivatized residue +def: "modification from UniMod Artifact" [PubMed:11968134, UniMod:337] +synonym: "Methylamine" RELATED PSI-MS-label [] +synonym: "Michael addition with methylamine" RELATED UniMod-description [] +xref: DiffAvg: "13.04" +xref: DiffFormula: "C 1 H 3 N 1 O -1" +xref: DiffMono: "13.031634" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00644 +name: O-acetylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OAcRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00394 ! acetylated residue +is_a: MOD:00671 ! O-acylated residue + +[Term] +id: MOD:00645 +name: S-acetylated residue +def: "A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SAcRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 O 1 S 0" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00394 ! acetylated residue +is_a: MOD:00672 ! S-acylated residue + +[Term] +id: MOD:00646 +name: acetylated L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "AcCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" +xref: DiffMono: "42.010565" +xref: Formula: "C 5 H 7 N 1 O 2 S 1" +xref: MassAvg: "145.18" +xref: MassMono: "145.019749" +xref: Origin: "C" +xref: Source: "natural" +is_a: MOD:00394 ! acetylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00647 +name: acetylated L-serine +def: "A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "AcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "S" +xref: Source: "natural" +is_a: MOD:00394 ! acetylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00648 +name: N,O-diacetylated L-serine +def: "A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine." [PubMed:16731519, PubMed:489587, PubMed:7309355, RESID:AA0051#var, RESID:AA0364#var] +comment: The samples were prepared using glacial acetic acid, and were probably artifactual [JSG]. +synonym: "(S)-2-acetamido-3-acetyloxypropanoic acid" EXACT PSI-MOD-alternate [] +synonym: "N,O-diacetyl-L-serine" EXACT PSI-MOD-alternate [] +synonym: "N,O-diacetylserine" EXACT PSI-MOD-alternate [] +synonym: "NOAc2Ser" EXACT PSI-MOD-label [] +xref: DiffAvg: "84.07" +xref: DiffFormula: "C 4 H 4 N 0 O 2" +xref: DiffMono: "84.021129" +xref: Formula: "C 7 H 10 N 1 O 4" +xref: MassAvg: "172.16" +xref: MassMono: "172.060983" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00408 ! N-acetylated residue +is_a: MOD:00644 ! O-acetylated residue +is_a: MOD:00647 ! acetylated L-serine +relationship: has_functional_parent MOD:00060 ! N-acetyl-L-serine +relationship: has_functional_parent MOD:00369 ! O-acetyl-L-serine + +[Term] +id: MOD:00649 +name: acylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "AcylRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00650 +name: N-myristoylated residue +def: "A protein modification that effectively replaces a residue amino group with a myristoylamino group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NMyrRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "210.36" +xref: DiffFormula: "C 14 H 26 O 1" +xref: DiffMono: "210.198365" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00438 ! myristoylated residue +is_a: MOD:00670 ! N-acylated residue + +[Term] +id: MOD:00651 +name: N-palmitoylated residue +def: "A protein modification that effectively replaces a residue amino group with a palmitoylamino group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NPamRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 O 1" +xref: DiffMono: "238.229666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00440 ! palmitoylated residue +is_a: MOD:00670 ! N-acylated residue + +[Term] +id: MOD:00652 +name: O-palmitoylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OPamRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 O 1" +xref: DiffMono: "238.229666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00440 ! palmitoylated residue +is_a: MOD:00671 ! O-acylated residue + +[Term] +id: MOD:00653 +name: S-palmitoylated residue +def: "A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SPamRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00440 ! palmitoylated residue +is_a: MOD:00672 ! S-acylated residue + +[Term] +id: MOD:00654 +name: S-methylated residue +def: "a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group" [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SMeRes" EXACT PSI-MOD-label [] +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00655 +name: S-myristoylated residue +def: "A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group." [PubMed:18688235] +synonym: "SMyrRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "210.36" +xref: DiffFormula: "C 14 H 26 O 1 S 0" +xref: DiffMono: "210.198365" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00438 ! myristoylated residue +is_a: MOD:00672 ! S-acylated residue + +[Term] +id: MOD:00656 +name: C-methylated residue +def: "A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group." [PubMed:18688235] +synonym: "CMeRes" EXACT PSI-MOD-label [] +is_a: MOD:00427 ! methylated residue + +[Term] +id: MOD:00657 +name: L-glutamic acid 5-methyl ester (Gln) +def: "A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester." [PubMed:16888, PubMed:6300110, RESID:AA0072#GLN, UniMod:528] +comment: This is known to be a natural modification of glutamine in prokaryotes. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate [] +synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate [] +synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate [] +synonym: "5-methyl L-glutamate" EXACT RESID-alternate [] +synonym: "deamidated 5-methyl esterified glutamine" EXACT PSI-MOD-alternate [] +synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] +synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate [] +synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate [] +synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name [] +synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] +synonym: "MOD_RES Glutamate methyl ester (Gln)" EXACT UniProt-feature [] +synonym: "O5MeGlu(Gln)" EXACT PSI-MOD-label [] +xref: DiffAvg: "15.01" +xref: DiffFormula: "C 1 H 1 N -1 O 1" +xref: DiffMono: "14.999666" +xref: Formula: "C 6 H 9 N 1 O 3" +xref: MassAvg: "143.14" +xref: MassMono: "143.058243" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01369 ! deamidated and methyl esterified residue +is_a: MOD:01453 ! L-glutamic acid 5-methyl ester +relationship: has_functional_parent MOD:00659 ! methylated glutamine + +[Term] +id: MOD:00658 +name: methylated arginine +def: "A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeArg" EXACT PSI-MOD-label [] +xref: Origin: "R" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00659 +name: methylated glutamine +def: "A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeGln" EXACT PSI-MOD-label [] +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:00660 +name: methylated cysteine +def: "A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeCys" EXACT PSI-MOD-label [] +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00661 +name: methylated histidine +def: "A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeHis" EXACT PSI-MOD-label [] +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00662 +name: methylated leucine +def: "A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeLeu" EXACT PSI-MOD-label [] +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00911 ! modified L-leucine residue + +[Term] +id: MOD:00663 +name: methylated lysine +def: "A protein modification that effectively converts an L-lysine residue to a methylated lysine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeLys" EXACT PSI-MOD-label [] +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00664 +name: stereoisomerized residue +def: "A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer." [PubMed:18688235] +synonym: "D-Res" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00665 +name: methylated alanine +def: "A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeAla" EXACT PSI-MOD-label [] +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00901 ! modified L-alanine residue + +[Term] +id: MOD:00666 +name: octanoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an octanoyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OctRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "126.20" +xref: DiffFormula: "C 8 H 14 N 0 O 1" +xref: DiffMono: "126.104465" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00667 +name: decanoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a decanoyl group." [PubMed:18688235] +synonym: "DecRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "154.25" +xref: DiffFormula: "C 10 H 18 N 0 O 1" +xref: DiffMono: "154.135765" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00668 +name: O-decanoylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group." [UniMod:449] +synonym: "Decanoyl" RELATED PSI-MS-label [] +synonym: "lipid" RELATED UniMod-description [] +synonym: "ODecRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "154.25" +xref: DiffFormula: "C 10 H 18 N 0 O 1" +xref: DiffMono: "154.135765" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00667 ! decanoylated residue +is_a: MOD:00671 ! O-acylated residue + +[Term] +id: MOD:00669 +name: O-octanoylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group." [UniMod:426] +subset: PSI-MOD-slim +synonym: "Octanoyl" RELATED PSI-MS-label [] +synonym: "octanoyl" RELATED UniMod-description [] +synonym: "OOctRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "126.20" +xref: DiffFormula: "C 8 H 14 N 0 O 1" +xref: DiffMono: "126.104465" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00666 ! octanoylated residue +is_a: MOD:00671 ! O-acylated residue + +[Term] +id: MOD:00670 +name: N-acylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NAcylRes" EXACT PSI-MOD-label [] +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:00671 +name: O-acylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OAcylRes" EXACT PSI-MOD-label [] +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:00672 +name: S-acylated residue +def: "A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SAcylRes" EXACT PSI-MOD-label [] +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:00673 +name: methylated asparagine +def: "A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeAsn" EXACT PSI-MOD-label [] +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00674 +name: amidated residue +def: "A protein modification that effectively replaces a carboxyl group with a carboxamido group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00675 +name: oxidized residue +def: "A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OxRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00676 +name: oxygenated residue +def: "A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OxyRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00675 ! oxidized residue + +[Term] +id: MOD:00677 +name: hydroxylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an hydroxyl group." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 16 +subset: PSI-MOD-slim +synonym: "Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate)" EXACT DeltaMass-label [] +synonym: "HyRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue + +[Term] +id: MOD:00678 +name: hydroxylated proline +def: "A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "HyPro" EXACT PSI-MOD-label [] +xref: Origin: "P" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00679 +name: carbon oxygenated residue +def: "A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "COxyRes" EXACT PSI-MOD-label [] +is_a: MOD:00676 ! oxygenated residue + +[Term] +id: MOD:00680 +name: sulfur oxygenated residue +def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SOxyRes" EXACT PSI-MOD-label [] +is_a: MOD:00676 ! oxygenated residue + +[Term] +id: MOD:00681 +name: hydroxylated lysine +def: "A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "HyLys" EXACT PSI-MOD-label [] +xref: Origin: "K" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00682 +name: hydroxylated arginine +def: "A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine." [PubMed:18688235] +synonym: "HyArg" EXACT PSI-MOD-label [] +xref: Origin: "R" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00683 +name: dehydrogenated residue +def: "A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "dHRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +is_a: MOD:00675 ! oxidized residue + +[Term] +id: MOD:00684 +name: deamidated L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid." [PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, RESID:AA0004#ASN, UniMod:7#N] +comment: incidental to RESID:AA0059 +subset: PSI-MOD-slim +synonym: "(2S)-2-aminobutanedioic acid" EXACT RESID-systematic [] +synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] +synonym: "aminosuccinic acid" EXACT RESID-alternate [] +synonym: "dNAsn" EXACT PSI-MOD-label [] +synonym: "L-aspartic acid" EXACT RESID-name [] +synonym: "MOD_RES Deamidated asparagine" EXACT UniProt-feature [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "C 0 H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00013 ! L-aspartic acid residue +is_a: MOD:00400 ! deamidated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00685 +name: deamidated L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to L-glutamic acid." [PubMed:1881881, PubMed:4565668, PubMed:4922541, PubMed:6692818, PubMed:9192900, PubMed:957425, RESID:AA0006#GLN, UniMod:7#Q] +subset: PSI-MOD-slim +synonym: "(2S)-2-aminopentanedioic acid" EXACT RESID-systematic [] +synonym: "1-aminopropane-1,3-dicarboxylic acid" EXACT RESID-alternate [] +synonym: "2-aminoglutaric acid" EXACT RESID-alternate [] +synonym: "2-azanylpentanedioic acid" EXACT RESID-alternate [] +synonym: "alpha-aminoglutaric acid" EXACT RESID-alternate [] +synonym: "dNGln" EXACT PSI-MOD-label [] +synonym: "glutaminic acid" EXACT RESID-alternate [] +synonym: "L-glutamic acid" EXACT RESID-name [] +synonym: "MOD_RES Deamidated glutamine" EXACT UniProt-feature [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "C 0 H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00015 ! L-glutamic acid residue +is_a: MOD:00400 ! deamidated residue + +[Term] +id: MOD:00686 +name: L-selenocysteine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process)." [PubMed:10523135, PubMed:2037562, PubMed:2963330, PubMed:6217842, PubMed:6714945, RESID:AA0022#CYS, UniMod:162#C] +comment: This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG]. +synonym: "(2R)-2-amino-3-selanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-selanylpropanoic acid" EXACT RESID-alternate [] +synonym: "3-selenylalanine" EXACT RESID-alternate [] +synonym: "L-selenocysteine" EXACT RESID-name [] +synonym: "NON_STD Selenocysteine" EXACT UniProt-feature [] +synonym: "Sec(Cys)" EXACT PSI-MOD-label [] +synonym: "SeCys" EXACT RESID-alternate [] +synonym: "selenium cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "46.91" +xref: DiffFormula: "C 0 H 0 N 0 O 0 S -1 Se 1" +xref: DiffMono: "47.944450" +xref: Formula: "C 3 H 5 N 1 O 1 Se 1" +xref: MassAvg: "150.05" +xref: MassMono: "150.953635" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00007 ! selenium substitution for sulfur +is_a: MOD:00031 ! L-selenocysteine residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00687 +name: thioether crosslinked residues +def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine." [PubMed:18688235] +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00688 +name: isopeptide crosslinked residues +def: "A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00689 +name: disulfide crosslinked residues +def: "A protein modification that crosslinks two cysteine residues by formation of a disulfide bond." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01619 ! multisulfide crosslinked residues + +[Term] +id: MOD:00690 +name: oxazole/thiazole ring crosslinked residues +def: "A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring." [PubMed:18688235] +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00691 +name: 5-imidazolinone ring crosslinked residues +def: "A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring." [PubMed:18688235] +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00692 +name: uncategorized crosslinked residues +def: "A protein crosslink modification that is not chemically categorized." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00693 +name: glycosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "GlycoRes" EXACT PSI-MOD-label [] +xref: Source: "natural" +is_a: MOD:00764 ! glycoconjugated residue + +[Term] +id: MOD:00694 +name: halogen containing residue +def: "A protein modification that effectively substitutes a halogen atom for a hydrogen atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "halogenated residue" EXACT PSI-MOD-alternate [] +synonym: "HalRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00695 +name: sulfated residue +def: "A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group." [DeltaMass:0, PubMed:14752058, UniMod:40] +comment: From DeltaMass: Average Mass: 80. +subset: PSI-MOD-slim +synonym: "O-Sulfonation" RELATED UniMod-description [] +synonym: "Sulfo" RELATED PSI-MS-label [] +synonym: "SulfRes" EXACT PSI-MOD-label [] +synonym: "Sulphonation (SO3H) (of PMC group)" EXACT DeltaMass-label [] +xref: DiffAvg: "80.06" +xref: DiffFormula: "O 3 S 1" +xref: DiffMono: "79.956815" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00860 ! sulfur containing modified residue + +[Term] +id: MOD:00696 +name: phosphorylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate')." [DeltaMass:0, UniMod:21] +comment: From DeltaMass: Average Mass: 80. +subset: PSI-MOD-slim +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "Phosphorylation" RELATED UniMod-description [] +synonym: "Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine)" EXACT DeltaMass-label [] +synonym: "PhosRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "H 1 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:00697 +name: flavin modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a flavin group." [UniMod:50] +subset: PSI-MOD-slim +synonym: "FAD" RELATED PSI-MS-label [] +synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] +synonym: "FlavRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0" +xref: DiffMono: "783.141485" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00698 +name: metal or metal cluster containing modified residue +def: "A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MetalRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00699 +name: porphyrin modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "PorphRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00700 +name: tetrapyrrole modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group." [PubMed:18688235] +synonym: "TetrapyrRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00701 +name: nucleotide or nucleic acid modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NucRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00702 +name: isotope labeled residue +def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common." [PubMed:18688235] +comment: In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426. +subset: PSI-MOD-slim +synonym: "IsoTagRes" EXACT PSI-MOD-label [] +synonym: "SILAC" EXACT PSI-MOD-alternate [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00703 +name: isoprenylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "IpRes" EXACT PSI-MOD-label [] +is_a: MOD:00001 ! alkylated residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00704 +name: dehydrated residue +def: "A protein modification that effectively forms a double bond by removing a molecule of water from a residue." [DeltaMass:0, UniMod:23] +subset: PSI-MOD-slim +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00705 +name: D-valine +def: "A protein modification that effectively converts an L-valine residue to D-valine." [ChEBI:30016, PubMed:15853325, RESID:AA0200] +synonym: "(R)-2-amino-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "alpha-amino-beta-methylbutyric acid" EXACT RESID-alternate [] +synonym: "alpha-aminoisovaleric acid" EXACT RESID-alternate [] +synonym: "D-Val" EXACT PSI-MOD-label [] +synonym: "D-valine" EXACT RESID-name [] +synonym: "MOD_RES D-valine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 5 H 9 N 1 O 1" +xref: MassAvg: "99.13" +xref: MassMono: "99.068414" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue + +[Term] +id: MOD:00706 +name: dehydrogenated tyrosine +def: "A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine." [UniMod:401#Y] +subset: PSI-MOD-slim +synonym: "dHTyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 9 H 7 N 1 O 2" +xref: MassAvg: "161.16" +xref: MassMono: "161.047678" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00707 +name: hydroxylated tyrosine +def: "a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine" [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "HyTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00708 +name: sulfur oxygenated L-cysteine +def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SOxyCys" EXACT PSI-MOD-label [] +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00680 ! sulfur oxygenated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00709 +name: sulfur oxygenated L-methionine +def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SOxyMet" EXACT PSI-MOD-label [] +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00680 ! sulfur oxygenated residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00710 +name: protonated-dimethylated residue +def: "A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups." [PubMed:18688235] +comment: For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation. +subset: PSI-MOD-slim +synonym: "Me2+Res" EXACT PSI-MOD-label [] +is_a: MOD:00429 ! dimethylated residue + +[Term] +id: MOD:00711 +name: trimethylated protonated-residue +def: "A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group." [PubMed:18688235] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation. +subset: PSI-MOD-slim +synonym: "Me3+Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0" +xref: DiffMono: "43.054227" +xref: FormalCharge: "1+" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00430 ! trimethylated residue + +[Term] +id: MOD:00712 +name: methylated proline +def: "A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MePro" EXACT PSI-MOD-label [] +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00713 +name: methylated glutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeGlu" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00714 +name: methylated glycine +def: "A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine." [PubMed:18688235] +synonym: "MeGly" EXACT PSI-MOD-label [] +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:00715 +name: methylated isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine." [PubMed:18688235] +synonym: "MeIle" EXACT PSI-MOD-label [] +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00910 ! modified L-isoleucine residue + +[Term] +id: MOD:00716 +name: methylated methionine +def: "A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeMet" EXACT PSI-MOD-label [] +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00717 +name: methylated phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MePhe" EXACT PSI-MOD-label [] +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:00718 +name: methylated tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine." [PubMed:18688235] +synonym: "MeTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00719 +name: L-methionine sulfoxide +def: "A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues." [DeltaMass:177, OMSSA:1, PubMed:21406390, PubMed:22116028, RESID:AA0581, UniMod:35#M] +comment: From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic [] +synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate [] +synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name [] +synonym: "L-methionine S-oxide" EXACT PSI-MOD-alternate [] +synonym: "L-methionine sulfoxide" EXACT PSI-MOD-alternate [] +synonym: "Methionyl Sulfoxide" EXACT DeltaMass-label [] +synonym: "MetO" EXACT PSI-MOD-label [] +synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature [] +synonym: "Oxidation" RELATED PSI-MS-label [] +synonym: "oxym" EXACT OMSSA-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 9 N 1 O 2 S 1" +xref: MassAvg: "147.19" +xref: MassMono: "147.035400" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00709 ! sulfur oxygenated L-methionine +is_a: MOD:01854 ! sulfur monooxygenated residue + +[Term] +id: MOD:00720 +name: L-methionine (R)-sulfoxide +def: "A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer." [ChEBI:45764, PubMed:21406390, PubMed:22116028, PubMed:23911929, RESID:AA0581] +synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic [] +synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate [] +synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name [] +synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature [] +synonym: "R-MetO" EXACT PSI-MOD-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 9 N 1 O 2 S 1" +xref: MassAvg: "147.19" +xref: MassMono: "147.035400" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00719 ! L-methionine sulfoxide + +[Term] +id: MOD:00721 +name: L-methionine (S)-sulfoxide +def: "A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer." [PubMed:18688235] +synonym: "S-MetO" EXACT PSI-MOD-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 9 N 1 O 2 S 1" +xref: MassAvg: "147.19" +xref: MassMono: "147.035400" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00719 ! L-methionine sulfoxide + +[Term] +id: MOD:00722 +name: monomethylated L-glutamine +def: "A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group." [OMSSA:14, UniMod:34#Q] +subset: PSI-MOD-slim +synonym: "Me1Gln" EXACT PSI-MOD-label [] +synonym: "methylq" EXACT OMSSA-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 10 N 2 O 2" +xref: MassAvg: "142.16" +xref: MassMono: "142.074228" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00659 ! methylated glutamine + +[Term] +id: MOD:00723 +name: N-acetylated L-lysine +def: "A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NAcLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 15 N 2 O 2" +xref: MassAvg: "171.22" +xref: MassMono: "171.113353" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00408 ! N-acetylated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00724 +name: N-methylated L-histidine +def: "A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group." [OMSSA:74, UniMod:34#H] +subset: PSI-MOD-slim +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "methylh" EXACT OMSSA-label [] +synonym: "NMeHis" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 9 N 3 O 1" +xref: MassAvg: "151.17" +xref: MassMono: "151.074562" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00661 ! methylated histidine + +[Term] +id: MOD:00725 +name: complex glycosylation +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond." [PubMed:18688235] +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00726 +name: glucosylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond." [PubMed:18688235] +synonym: "Glc" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00727 +name: mannosylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond," [PubMed:18688235] +synonym: "Man" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00728 +name: galactosylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond." [PubMed:18688235] +synonym: "Gal" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00729 +name: pentosylated residue +def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond" [DeltaMass:172] +comment: for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146 +synonym: "Pent" EXACT PSI-MOD-label [] +synonym: "Pentoses (Ara, Rib, Xyl)" EXACT DeltaMass-label [] +synonym: "Pentosyl" EXACT DeltaMass-label [] +xref: DiffAvg: "132.12" +xref: DiffFormula: "C 5 H 8 O 4" +xref: DiffMono: "132.042259" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00730 +name: arabinosylated +def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond" [PubMed:18688235] +synonym: "Ara" EXACT PSI-MOD-label [] +xref: DiffAvg: "132.12" +xref: DiffFormula: "C 5 H 8 O 4" +xref: DiffMono: "132.042259" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00729 ! pentosylated residue + +[Term] +id: MOD:00731 +name: ribosylated +def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond" [PubMed:18688235] +synonym: "Rib" EXACT PSI-MOD-label [] +xref: DiffAvg: "132.12" +xref: DiffFormula: "C 5 H 8 O 4" +xref: DiffMono: "132.042259" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00729 ! pentosylated residue + +[Term] +id: MOD:00732 +name: xylosylated +def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond" [PubMed:18688235] +synonym: "Xyl" EXACT PSI-MOD-label [] +xref: DiffAvg: "132.12" +xref: DiffFormula: "C 5 H 8 O 4" +xref: DiffMono: "132.042259" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00729 ! pentosylated residue + +[Term] +id: MOD:00733 +name: N-acetylaminoglucosylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond." [PubMed:18688235] +synonym: "GlcNAc" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00436 ! N-acetylhexosaminylated + +[Term] +id: MOD:00734 +name: N-acetylaminogalactosylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond." [DeltaMass:247] +comment: From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex +synonym: "GalNAc" EXACT PSI-MOD-label [] +synonym: "N-acetylhexosamines (GalNAc, GlcNAc)" EXACT DeltaMass-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00436 ! N-acetylhexosaminylated + +[Term] +id: MOD:00735 +name: hexosuronylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond." [PubMed:18688235] +synonym: "HexA" EXACT PSI-MOD-label [] +xref: DiffAvg: "176.12" +xref: DiffFormula: "C 6 H 8 O 6" +xref: DiffMono: "176.032088" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00736 +name: deoxyhexosylated +def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 146 +subset: PSI-MOD-slim +synonym: "Deoxyhexoses (Fuc, Rha)" EXACT DeltaMass-label [] +synonym: "dHex" EXACT PSI-MOD-label [] +xref: DiffAvg: "146.14" +xref: DiffFormula: "C 6 H 10 O 4" +xref: DiffMono: "146.057909" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00737 +name: N-acetylneuraminylated +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 291 +synonym: "N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA)" EXACT DeltaMass-label [] +synonym: "NeuNAc" EXACT PSI-MOD-label [] +xref: DiffAvg: "291.26" +xref: DiffFormula: "C 11 H 17 N 1 O 8" +xref: DiffMono: "291.095417" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00738 +name: iron containing modified residue +def: "A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion." [PubMed:18688235] +synonym: "FeRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00739 +name: iron-sulfur cluster containing modification +def: "A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms." [PubMed:18688235] +synonym: "FeSRes" EXACT PSI-MOD-label [] +is_a: MOD:00738 ! iron containing modified residue +is_a: MOD:00860 ! sulfur containing modified residue + +[Term] +id: MOD:00740 +name: manganese containing modified residue +def: "A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion." [PubMed:18688235] +synonym: "MnRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00741 +name: nickel containing modified residue +def: "A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion." [PubMed:18688235] +synonym: "NiRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00742 +name: copper containing modified residue +def: "A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion." [PubMed:18688235] +synonym: "CuRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00743 +name: molybdenum containing modified residue +def: "A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MoRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00744 +name: molybdenum pterin containing modification +def: "A protein modification containing a molybdenum atom in a pterin ring system." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MoPterRes" EXACT PSI-MOD-label [] +is_a: MOD:00743 ! molybdenum containing modified residue +is_a: MOD:00748 ! pterin modified residue + +[Term] +id: MOD:00745 +name: selenium containing residue +def: "A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "SeRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00746 +name: tungsten containing modified residue +def: "A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion." [PubMed:18688235] +synonym: "WRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00747 +name: sodium containing modified residue +def: "A protein modification that effectively substitutes a sodium atom for a hydrogen atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "NaRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00748 +name: pterin modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a pterin group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "PterRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00749 +name: sulfur substitution for oxygen +def: "A protein modification that effectively substitutes a sulfur atom for an oxygen atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "S(O)Res" EXACT PSI-MOD-label [] +is_a: MOD:00860 ! sulfur containing modified residue + +[Term] +id: MOD:00750 +name: deoxyribonucleic acid linked residue +def: "A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond." [PubMed:18688235] +synonym: "DNARes" EXACT PSI-MOD-label [] +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue + +[Term] +id: MOD:00751 +name: ribonucleic acid linked residue +def: "a protein modification" [PubMed:18688235] +synonym: "RNARes" EXACT PSI-MOD-label [] +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue + +[Term] +id: MOD:00752 +name: adenosine diphosphoribosyl (ADP-ribosyl) modified residue +def: "A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 541. +subset: PSI-MOD-slim +synonym: "ADP-rybosylation (from NAD)" EXACT DeltaMass-label [] +synonym: "ADPRibRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue + +[Term] +id: MOD:00753 +name: chlorinated residue +def: "A protein modification that effectively substitutes a chlorine atom for a hydrogen atom." [PubMed:18688235] +synonym: "ClRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue + +[Term] +id: MOD:00754 +name: brominated residue +def: "A protein modification that effectively substitutes a bromine atom for a hydrogen atom." [PubMed:18688235] +synonym: "BrRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue + +[Term] +id: MOD:00755 +name: iodinated residue +def: "A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "IRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue + +[Term] +id: MOD:00756 +name: 4-hydroxy-D-valine +def: "A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine." [PubMed:15853325, RESID:AA0388] +synonym: "(2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "4-hydroxy-D-valine" EXACT RESID-name [] +synonym: "D-4HyVal" EXACT PSI-MOD-label [] +synonym: "D-gamma-hydroxyvaline" EXACT RESID-alternate [] +synonym: "MOD_RES D-4-hydroxyvaline" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 9 N 1 O 2" +xref: MassAvg: "115.13" +xref: MassMono: "115.063329" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00664 ! stereoisomerized residue + +[Term] +id: MOD:00757 +name: O4-galactosyl-L-hydroxyproline +def: "A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline." [RESID:AA0389] +comment: secondary to RESID:AA0030 +synonym: "(2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "4-(beta-D-galactopyranosyloxy)proline" EXACT RESID-alternate [] +synonym: "4-(galactosyloxy)proline" EXACT RESID-alternate [] +synonym: "beta-galactopyranosyl-4-hydroxyproline" EXACT RESID-alternate [] +synonym: "O4-galactosyl-L-hydroxyproline" EXACT RESID-name [] +synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate [] +xref: DiffAvg: "178.14" +xref: DiffFormula: "C 6 H 10 N 0 O 6" +xref: DiffMono: "178.047738" +xref: Formula: "C 11 H 17 N 1 O 7" +xref: MassAvg: "275.26" +xref: MassMono: "275.100502" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:00758 +name: O4-(N-acetylamino)glucosyl-L-hydroxyproline +def: "A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline." [PubMed:15238247, PubMed:9660787, RESID:AA0390] +comment: secondary to RESID:AA0030 +synonym: "(2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "4-(N-acetylglucosaminyloxy)proline" EXACT RESID-alternate [] +synonym: "4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline" EXACT RESID-alternate [] +synonym: "alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline" EXACT RESID-alternate [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "O4-(N-acetylamino)glucosyl-L-hydroxyproline" EXACT RESID-name [] +synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate [] +synonym: "O4GlcNAcHyPro" EXACT PSI-MOD-label [] +xref: DiffAvg: "219.19" +xref: DiffFormula: "C 8 H 13 N 1 O 6" +xref: DiffMono: "219.074287" +xref: Formula: "C 13 H 20 N 2 O 7" +xref: MassAvg: "316.31" +xref: MassMono: "316.127051" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00448 ! N-acetylaminoglucosylated residue +is_a: MOD:01677 ! O4-(N-acetylamino)hexosyl-L-hydroxyproline + +[Term] +id: MOD:00759 +name: fucosylated biantennary (-1 galactose) +def: "modification from UniMod N-linked glycosylation" [UniMod:307] +synonym: "dHex(1)Hex(4)HexNAc(4)" RELATED PSI-MS-label [] +synonym: "Fucosylated biantennary (-1 galactose)" RELATED UniMod-description [] +xref: DiffAvg: "1607.48" +xref: DiffFormula: "C 62 H 102 N 4 O 44" +xref: DiffMono: "1606.586693" +xref: Formula: "C 66 H 108 N 6 O 46" +xref: MassAvg: "1721.59" +xref: MassMono: "1720.629620" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00760 +name: biantennary +def: "modification from UniMod N-linked glycosylation - missing ref" [UniMod:311] +synonym: "Biantennary" RELATED UniMod-description [] +synonym: "Hex(5)HexNAc(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "1623.48" +xref: DiffFormula: "C 62 H 102 N 4 O 45" +xref: DiffMono: "1622.581607" +xref: Formula: "C 66 H 108 N 6 O 47" +xref: MassAvg: "1737.59" +xref: MassMono: "1736.624535" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00761 +name: monohexosylated (Hex1) +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond." [PubMed:18688235] +synonym: "Hex1" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00434 ! hexosylated residue + +[Term] +id: MOD:00762 +name: biantennary (-2 galactose) +def: "modification from UniMod N-linked glycosylation - missing ref" [UniMod:309] +synonym: "Biantennary (-2 galactose)" RELATED UniMod-description [] +synonym: "Hex(3)HexNAc(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "1299.20" +xref: DiffFormula: "C 50 H 82 N 4 O 35" +xref: DiffMono: "1298.475960" +xref: Formula: "C 54 H 88 N 6 O 37" +xref: MassAvg: "1413.30" +xref: MassMono: "1412.518888" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00763 +name: biantennary (-1 galactose) +def: "modification from UniMod N-linked glycosylation - missing ref" [UniMod:310] +synonym: "Biantennary (-1 galactose)" RELATED UniMod-description [] +synonym: "Hex(4)HexNAc(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "1461.34" +xref: DiffFormula: "C 56 H 92 N 4 O 40" +xref: DiffMono: "1460.528784" +xref: Formula: "C 60 H 98 N 6 O 42" +xref: MassAvg: "1575.44" +xref: MassMono: "1574.571711" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:00764 +name: glycoconjugated residue +def: "A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct." [PubMed:18688235, PubMed:3743566] +subset: PSI-MOD-slim +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00765 +name: cysteinylation (disulfide with free L-cysteine) +def: "A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine." [DeltaMass:260, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025#CYS1, UniMod:312] +comment: This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283 +subset: PSI-MOD-slim +synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer [] +synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate [] +synonym: "3,3'-dithiodialanine" EXACT RESID-alternate [] +synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate [] +synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate [] +synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate [] +synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate [] +synonym: "Cysteinylation" EXACT DeltaMass-label [] +synonym: "dicysteine" EXACT RESID-alternate [] +synonym: "L-cystine" EXACT RESID-name [] +synonym: "MOD_RES S-cysteinyl cysteine" EXACT UniProt-feature [] +synonym: "S-cystenyl cystenyl" EXACT DeltaMass-label [] +synonym: "SCysCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "119.14" +xref: DiffFormula: "C 3 H 5 N 1 O 2 S 1" +xref: DiffMono: "119.004099" +xref: Formula: "C 6 H 10 N 2 O 3 S 2" +xref: MassAvg: "222.28" +xref: MassMono: "222.013284" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01862 ! disulfide conjugated residue + +[Term] +id: MOD:00766 +name: C terminal -K from HC of MAb +def: "modification from UniMod Post-translational - C-terminal loss of lysine" [PubMed:16078144, UniMod:313] +synonym: "Loss of C-terminal K from Heavy Chain of MAb" RELATED UniMod-description [] +synonym: "Lys-loss" RELATED PSI-MS-label [] +xref: DiffAvg: "-128.18" +xref: DiffFormula: "C -6 H -12 N -2 O -1" +xref: DiffMono: "-128.094963" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: TermSpec: "C-term" +is_a: MOD:00003 ! UniMod + +[Term] +id: MOD:00767 +name: glycated residue +def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct." [PubMed:18688235] +xref: Source: "artifact" +is_a: MOD:00764 ! glycoconjugated residue + +[Term] +id: MOD:00768 +name: methionine oxidation with neutral loss of 80 Da +def: "Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H." [PubMed:18688235, PubMed:9004526] +comment: Originally created from UniMod:508 that was later deleted. +xref: DiffAvg: "-80.10" +xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1" +xref: DiffMono: "-79.993200" +xref: Formula: "C 4 H 5 N 1 O 1 S 0" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00431 ! modified residue with a secondary neutral loss + +[Term] +id: MOD:00769 +name: residues isobaric at 71.0-71.1 Da +def: "Natural or modified residues with a mass of 71.0-71.1 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da + +[Term] +id: MOD:00770 +name: residues isobaric at a resolution below 0.01 Da +def: "Natural or modified residues that are isobaric at a resolution below 0.01 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da + +[Term] +id: MOD:00771 +name: residues isobaric at 166.98-167.00 Da +def: "Natural or modified residues with a mass of 166.98-167.00 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da + +[Term] +id: MOD:00772 +name: vanadium containing modified residue +def: "A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion." [PubMed:18688235] +synonym: "VRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00773 +name: residues isobaric at 181.00-181.02 Da +def: "Natural or modified residues with a mass of 181.00-181.02 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da + +[Term] +id: MOD:00774 +name: residues isobaric at 243.02-243.03 Da +def: "Natural or modified residues with a mass of 243.02-243.03 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da + +[Term] +id: MOD:00775 +name: L-asparagine (His) +def: "An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation." [OMSSA:54, PubMed:9252331, UniMod:348] +synonym: "His->Asn" RELATED PSI-MS-label [] +synonym: "his2asnh" EXACT OMSSA-label [] +synonym: "histidine oxidation to aspargine" RELATED UniMod-description [] +xref: DiffAvg: "-23.04" +xref: DiffFormula: "C -2 H -1 N -1 O 1" +xref: DiffMono: "-23.015984" +xref: Formula: "C 4 H 6 N 2 O 2" +xref: MassAvg: "114.10" +xref: MassMono: "114.042927" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00012 ! L-asparagine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00776 +name: L-aspartic acid (His) +def: "An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation." [OMSSA:55, PubMed:9252331, UniMod:349] +comment: From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG]. +synonym: "His->Asp" RELATED PSI-MS-label [] +synonym: "his2asph" EXACT OMSSA-label [] +synonym: "histidine oxidation to aspartic acid" RELATED UniMod-description [] +xref: DiffAvg: "-22.05" +xref: DiffFormula: "C -2 H -2 N -2 O 2" +xref: DiffMono: "-22.031969" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00013 ! L-aspartic acid residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00777 +name: residues isobaric at 182.96-182.98 Da +def: "Natural or modified residues with a mass of 182.96-182.98 Da." [PubMed:18688235] +is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da +is_a: MOD:00778 ! residues isobaric at 182.9-183.0 Da + +[Term] +id: MOD:00778 +name: residues isobaric at 182.9-183.0 Da +def: "Natural or modified residues with a mass of 182.9-183.0 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da + +[Term] +id: MOD:00779 +name: lysine oxidation to aminoadipic semialdehyde +def: "OBSOLETE because redundant with MOD:00130. Remap to MOD:00130." [DeltaMass:352, PubMed:11332453, PubMed:358196, PubMed:5337886, PubMed:5529814, UniMod:352] +comment: From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. +synonym: "Oxidation of lysine (to aminoadipic semialdehyde)" EXACT DeltaMass-label [] +xref: DiffAvg: "-1.03" +xref: DiffFormula: "H -3 N -1 O 1" +xref: DiffMono: "-1.031634" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00780 +name: N-acetyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine." [PubMed:18688235] +comment: This modification has not been observed to occur naturally. +synonym: "AcAsn" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 6 H 8 N 2 O 3" +xref: MassAvg: "156.14" +xref: MassMono: "156.053492" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00781 +name: N2-acetyl-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine." [PubMed:18688235] +comment: This modification has not been observed to occur naturally. +synonym: "AcHis" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 9 N 3 O 2" +xref: MassAvg: "179.18" +xref: MassMono: "179.069477" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00782 +name: N-acetyl-L-leucine +def: "A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine." [PubMed:18688235] +comment: This modification has not been observed to occur naturally. +synonym: "AcLeu" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 8 H 14 N 1 O 2" +xref: MassAvg: "156.20" +xref: MassMono: "156.102454" +xref: Origin: "L" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00911 ! modified L-leucine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00783 +name: dimethylated L-arginine +def: "A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups." [OMSSA:37, UniMod:36#R] +subset: PSI-MOD-slim +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "dimethylr" EXACT OMSSA-label [] +synonym: "NNMe2Arg" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 4 O 1" +xref: MassAvg: "184.24" +xref: MassMono: "184.132411" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00429 ! dimethylated residue +is_a: MOD:00658 ! methylated arginine + +[Term] +id: MOD:00784 +name: N-acetyl-L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine." [PubMed:18688235] +comment: This modification has not been observed to occur naturally. +synonym: "AcPhe" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 11 H 11 N 1 O 2" +xref: MassAvg: "189.21" +xref: MassMono: "189.078979" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00785 +name: N2-acetyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan." [PubMed:18688235] +comment: This modification has not been observed to occur naturally. +synonym: "AcTrp" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 13 H 12 N 2 O 2" +xref: MassAvg: "228.25" +xref: MassMono: "228.089878" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00918 ! modified L-tryptophan residue +is_a: MOD:01458 ! alpha-amino acetylated residue + +[Term] +id: MOD:00786 +name: deuterium substituted residue +def: "A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "D(H)Res" EXACT PSI-MOD-label [] +is_a: MOD:00839 ! (2)H deuterium labeled residue + +[Term] +id: MOD:00787 +name: diisopropylphosphoserine +def: "modification from UniMod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin" [UniMod:362] +synonym: "Diisopropylphosphate" RELATED UniMod-interim [] +synonym: "O-Diisopropylphosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "164.14" +xref: DiffFormula: "C 6 H 13 O 3 P 1" +xref: DiffMono: "164.060231" +xref: Formula: "C 9 H 18 N 1 O 5 P 1" +xref: MassAvg: "251.22" +xref: MassMono: "251.092259" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00788 +name: isopropylphosphotyrosine +def: "modification from UniMod" [UniMod:363] +synonym: "Isopropylphospho" RELATED UniMod-interim [] +synonym: "O-Isopropylphosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "122.06" +xref: DiffFormula: "C 3 H 7 O 3 P 1" +xref: DiffMono: "122.013281" +xref: Formula: "C 12 H 16 N 1 O 5 P 1" +xref: MassAvg: "285.24" +xref: MassMono: "285.076609" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00789 +name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form +def: "modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied." [PubMed:15602776, UniMod:364, URL:http\://www.serva.de/products/sheets/39230-E.pdf] +synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form" RELATED UniMod-description [] +synonym: "ICPL:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "111.04" +xref: DiffFormula: "(13)C 6 H 3 N 1 O 1" +xref: DiffMono: "111.041593" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00790 +name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form +def: "modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied." [PubMed:15602776, UniMod:365, URL:http\://www.serva.de/products/sheets/39230-E.pdf] +synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form" RELATED UniMod-description [] +synonym: "ICPL" RELATED PSI-MS-label [] +xref: DiffAvg: "105.02" +xref: DiffFormula: "(12)C 6 H 3 N 1 O 1" +xref: DiffMono: "105.021464" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00791 +name: 1x(18)O labeled deamidated L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O." [PubMed:8382902, UniMod:366#Q] +subset: PSI-MOD-slim +synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] +synonym: "Deamidation in presence of O18" RELATED UniMod-description [] +xref: DiffAvg: "2.99" +xref: DiffFormula: "H -1 N -1 (18)O 1" +xref: DiffMono: "2.988262" +xref: Formula: "C 5 H 7 N 1 (16)O 2 (18)O 1" +xref: MassAvg: "131.05" +xref: MassMono: "131.046839" +xref: Origin: "Q" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00685 ! deamidated L-glutamine +is_a: MOD:00852 ! 1x(18)O labeled deamidated residue + +[Term] +id: MOD:00792 +name: deuterium monosubstituted residue +def: "A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "D(H)1Res" EXACT PSI-MOD-label [] +is_a: MOD:00786 ! deuterium substituted residue + +[Term] +id: MOD:00793 +name: dehydroalanine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to dehydroalanine." [ChEBI:17123, DeltaMass:8, PubMed:10220322, PubMed:11212008, PubMed:1547888, PubMed:15799070, PubMed:1815586, PubMed:20805503, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181#CYS, UniMod:368] +comment: From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG]. +subset: PSI-MOD-slim +synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] +synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] +synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "anhydroserine" EXACT RESID-alternate [] +synonym: "Cys->Dha" RELATED PSI-MS-label [] +synonym: "dehydroalanine" EXACT RESID-name [] +synonym: "Dehydroalanine (from Cysteine)" EXACT DeltaMass-label [] +synonym: "Dehydroalanine (from Cysteine)" RELATED UniMod-description [] +synonym: "Dha" EXACT RESID-alternate [] +synonym: "dHAla(Cys)" EXACT PSI-MOD-label [] +synonym: "MOD_RES 2,3-didehydroalanine (Cys)" EXACT UniProt-feature [] +xref: DiffAvg: "-34.08" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1" +xref: DiffMono: "-33.987721" +xref: Formula: "C 3 H 3 N 1 O 1" +xref: MassAvg: "69.06" +xref: MassMono: "69.021464" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01168 ! dehydroalanine + +[Term] +id: MOD:00794 +name: pyrrolidone from proline +def: "OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477." [PubMed:9252331, UniMod:369] +comment: This UniMod entry appears to have come from the same description in PubMed:9252331 as UniMod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657. +synonym: "Pro->Pyrrolidone" RELATED UniMod-interim [] +synonym: "Pyrrolidone from Proline" RELATED UniMod-description [] +xref: DiffAvg: "-28.01" +xref: DiffFormula: "C -1 O -1" +xref: DiffMono: "-27.994915" +xref: Formula: "C 4 H 7 N 1 O 0" +xref: MassAvg: "69.11" +xref: MassMono: "69.057849" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00795 +name: Michael addition of hydroxymethylvinyl ketone to cysteine +def: "modification from UniMod" [PubMed:11743741, UniMod:371] +synonym: "HMVK" RELATED PSI-MS-label [] +synonym: "Michael addition of hydroxymethylvinyl ketone to cysteine" RELATED UniMod-description [] +xref: DiffAvg: "86.09" +xref: DiffFormula: "C 4 H 6 O 2" +xref: DiffMono: "86.036779" +xref: Formula: "C 7 H 11 N 1 O 3 S 1" +xref: MassAvg: "189.23" +xref: MassMono: "189.045964" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00796 +name: L-ornithine (Arg) +def: "A protein modification that effectively converts an L-arginine residue to L-ornithine." [DeltaMass:129, OMSSA:163, PubMed:15489230, UniMod:372] +subset: PSI-MOD-slim +synonym: "Arg->Orn" RELATED PSI-MS-label [] +synonym: "arg2orn" EXACT OMSSA-label [] +synonym: "Ornithine (from Arginine)" EXACT DeltaMass-label [] +synonym: "Ornithine from Arginine" RELATED UniMod-description [] +synonym: "Ornithyl" EXACT DeltaMass-label [] +xref: DiffAvg: "-42.04" +xref: DiffFormula: "C -1 H -2 N -2" +xref: DiffMono: "-42.021798" +xref: Formula: "C 5 H 10 N 2 O 1" +xref: MassAvg: "114.15" +xref: MassMono: "114.079313" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00797 +name: 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal +def: "a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal" [PubMed:4696757, PubMed:7999765, PubMed:8664284, RESID:AA0391] +synonym: "(2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid" EXACT RESID-alternate [] +synonym: "2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid" EXACT RESID-alternate [] +synonym: "2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal" EXACT RESID-name [] +synonym: "cysteinyl pyruvate O-phosphothioketal" EXACT RESID-alternate [] +synonym: "MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal" EXACT UniProt-feature [] +synonym: "phosphoenolpyruvate cysteine adduct" EXACT RESID-alternate [] +synonym: "phospholactoyl cysteine adduct" EXACT RESID-alternate [] +synonym: "S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine" EXACT RESID-alternate [] +synonym: "SPEPCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "168.04" +xref: DiffFormula: "C 3 H 5 N 0 O 6 P 1 S 0" +xref: DiffMono: "167.982375" +xref: Formula: "C 6 H 10 N 1 O 7 P 1 S 1" +xref: MassAvg: "271.18" +xref: MassMono: "270.991559" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00798 +name: half cystine +def: "A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed." [PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, UniMod:374] +synonym: "Dehydro" RELATED PSI-MS-label [] +synonym: "Half of a disulfide bridge" RELATED UniMod-description [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0 S 0" +xref: DiffMono: "-1.007825" +xref: Formula: "C 3 H 4 N 1 O 1 S 1" +xref: MassAvg: "102.13" +xref: MassMono: "102.001360" +xref: Origin: "C" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00799 +name: S-galactosyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine." [PubMed:11945907, RESID:AA0392] +comment: The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "S-(beta-D-galactopyranosyl)cysteine" EXACT RESID-alternate [] +synonym: "S-galactosyl-L-cysteine" EXACT RESID-name [] +synonym: "S-glycosyl-cysteine" EXACT RESID-alternate [] +synonym: "SGalCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5 S 0" +xref: DiffMono: "162.052823" +xref: Formula: "C 9 H 15 N 1 O 6 S 1" +xref: MassAvg: "265.28" +xref: MassMono: "265.062008" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00426 ! S-glycosylated residue +is_a: MOD:00476 ! galactosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00800 +name: L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide +def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide." [PubMed:2345152, RESID:AA0393] +comment: Cross-link 2; incidental to RESID:AA0300. +synonym: "CysHis-[V7Fe9S]" EXACT PSI-MOD-label [] +synonym: "L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide" EXACT RESID-name [] +synonym: "nitrogenase iron-vanadium cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "932.51" +xref: DiffFormula: "C 7 Fe 7 H 6 N 0 O 7 S 9 V 1" +xref: DiffMono: "932.248513" +xref: Formula: "C 16 Fe 7 H 18 N 4 O 9 S 10 V 1" +xref: MassAvg: "1172.80" +xref: MassMono: "1172.316610" +xref: Origin: "C, H" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00772 ! vanadium containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00801 +name: L-cysteinyl-L-histidino-homocitryl octairon nonasulfide +def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide." [PubMed:8392330, RESID:AA0394] +comment: Cross-link 2; incidental to RESID:AA0300. +synonym: "CysHis-[8Fe9S]" EXACT PSI-MOD-label [] +synonym: "L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide" EXACT RESID-name [] +synonym: "nitrogenase iron-iron cofactor" EXACT RESID-alternate [] +xref: DiffAvg: "937.42" +xref: DiffFormula: "C 7 Fe 8 H 6 N 0 O 7 S 9" +xref: DiffMono: "937.240588" +xref: FormalCharge: "2-" +xref: Formula: "C 16 Fe 8 H 18 N 4 O 9 S 10" +xref: MassAvg: "1177.70" +xref: MassMono: "1177.308685" +xref: Origin: "C, H" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00802 +name: L-histidino vanadium tetraoxide +def: "a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide" [PubMed:10543953, PubMed:16494433, PubMed:8552646, RESID:AA0395] +synonym: "(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium" EXACT RESID-alternate [] +synonym: "1'-vanadato-L-histidine" EXACT RESID-alternate [] +synonym: "bromoperoxidase vanadium cofactor" EXACT RESID-alternate [] +synonym: "chloroperoxidase vanadium cofactor" EXACT RESID-alternate [] +synonym: "dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate" EXACT RESID-systematic [] +synonym: "haloperoxidase vanadium cofactor" EXACT RESID-alternate [] +synonym: "histidine-1-vanadate" EXACT RESID-alternate [] +synonym: "histidine-N(epsilon)-vanadate" EXACT RESID-alternate [] +synonym: "histidine-N1'-vanadate" EXACT RESID-alternate [] +synonym: "L-histidino vanadium tetraoxide" EXACT RESID-name [] +synonym: "N(tau)-vanadatohistidine" EXACT RESID-alternate [] +synonym: "NtauH2VO4His" EXACT PSI-MOD-label [] +synonym: "tele-vanadatohistidine" EXACT RESID-alternate [] +xref: DiffAvg: "116.95" +xref: DiffFormula: "C 0 H 2 N 0 O 4 V 1" +xref: DiffMono: "116.939268" +xref: Formula: "C 6 H 9 N 3 O 5 V 1" +xref: MassAvg: "254.10" +xref: MassMono: "253.998180" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00772 ! vanadium containing modified residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00803 +name: 3-(S-L-cysteinyl)-L-tyrosine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine." [PubMed:15342250, RESID:AA0396] +comment: Cross-link 2. +synonym: "(2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-alternate [] +synonym: "3-(L-cystein-S-yl)-L-tyrosine" EXACT RESID-name [] +synonym: "CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr)" EXACT UniProt-feature [] +synonym: "S-(tyros-3'-yl)cysteine" EXACT RESID-alternate [] +synonym: "XLNKSCys3Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 12 H 12 N 2 O 3 S 1" +xref: MassAvg: "264.30" +xref: MassMono: "264.056863" +xref: Origin: "C, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01993 ! beta-carbon thioether crosslinked residues + +[Term] +id: MOD:00804 +name: O-glucosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine." [PubMed:10734111, PubMed:2105311, PubMed:2511201, RESID:AA0397] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (Glc)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] +synonym: "O-glucosyl-L-serine" EXACT RESID-name [] +synonym: "O-glycosylserine" EXACT RESID-alternate [] +synonym: "O3-glucosylserine" EXACT RESID-alternate [] +synonym: "OGlcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 9 H 15 N 1 O 7" +xref: MassAvg: "249.22" +xref: MassMono: "249.084852" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine +is_a: MOD:00433 ! glucosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) + +[Term] +id: MOD:00805 +name: O-(N-acetylamino)glucosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine." [PubMed:3086323, PubMed:8404891, RESID:AA0398] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (GlcNAc)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O-(N-acetylamino)glucosyl-L-serine" EXACT RESID-name [] +synonym: "O-(N-acetylglucosaminyl)serine" EXACT RESID-alternate [] +synonym: "O-glycosylserine" EXACT RESID-alternate [] +synonym: "O-seryl-beta-N-acetylglucosaminide" EXACT RESID-alternate [] +synonym: "O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-(N-acetylglucosaminyl)serine" EXACT RESID-alternate [] +synonym: "OGlcNAcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 11 H 18 N 2 O 7" +xref: MassAvg: "290.27" +xref: MassMono: "290.111401" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00448 ! N-acetylaminoglucosylated residue +is_a: MOD:01675 ! O-(N-acetylamino)hexosyl-L-serine + +[Term] +id: MOD:00806 +name: O-(N-acetylamino)glucosyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine." [PubMed:3086323, PubMed:8404891, RESID:AA0399] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (GlcNAc)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine" EXACT RESID-alternate [] +synonym: "O-(N-acetylamino)glucosyl-L-threonine" EXACT RESID-name [] +synonym: "O-(N-acetylglucosaminyl)-L-threonine" EXACT RESID-alternate [] +synonym: "O-glycosylthreonine" EXACT RESID-alternate [] +synonym: "O-threonyl-beta-N-acetylglucosaminide" EXACT RESID-alternate [] +synonym: "O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine" EXACT RESID-alternate [] +synonym: "O3-(N-acetylglucosaminyl)threonine" EXACT RESID-alternate [] +synonym: "OGlcNAcThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 12 H 20 N 2 O 7" +xref: MassAvg: "304.30" +xref: MassMono: "304.127051" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00448 ! N-acetylaminoglucosylated residue +is_a: MOD:01676 ! O-(N-acetylamino)hexosyl-L-threonine + +[Term] +id: MOD:00807 +name: pyruvic acid (Ser) +def: "A protein modification that effectively converts an L-serine residue to pyruvic acid." [DeltaMass:23, PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127#SER, UniMod:385#S] +comment: DeltaMass gives mass 70 and difference mass -16 with no formula +subset: PSI-MOD-slim +synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES Pyruvic acid (Ser)" EXACT UniProt-feature [] +synonym: "Pyruvate" EXACT DeltaMass-label [] +synonym: "pyruvic acid" EXACT RESID-name [] +synonym: "Pyruvoyl- (Serine)" EXACT DeltaMass-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 3 H 3 O 2" +xref: MassAvg: "71.06" +xref: MassMono: "71.013304" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01154 ! pyruvic acid +is_a: MOD:01160 ! deaminated residue + +[Term] +id: MOD:00808 +name: O-galactosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-galactosylserine." [PubMed:666730, RESID:AA0400] +synonym: "(2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (Gal)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] +synonym: "O-galactosyl-L-serine" EXACT RESID-name [] +synonym: "O-glycosylserine" EXACT RESID-alternate [] +synonym: "O3-galactosylserine" EXACT RESID-alternate [] +synonym: "OGalSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 9 H 15 N 1 O 7" +xref: MassAvg: "249.22" +xref: MassMono: "249.084852" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine +is_a: MOD:00476 ! galactosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) + +[Term] +id: MOD:00809 +name: O-galactosyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine." [PubMed:2673008, RESID:AA0401] +synonym: "(2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (Gal)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] +synonym: "O-galactosyl-L-threonine" EXACT RESID-name [] +synonym: "O-glycosylthreonine" EXACT RESID-alternate [] +synonym: "O3-galactosylthreonine" EXACT RESID-alternate [] +synonym: "OGalThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 10 H 17 N 1 O 7" +xref: MassAvg: "263.25" +xref: MassMono: "263.100502" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00476 ! galactosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:01348 ! O-hexosylated threonine + +[Term] +id: MOD:00810 +name: O-mannosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-mannosylserine." [PubMed:391559, RESID:AA0402] +synonym: "(2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Man)" EXACT UniProt-feature [] +synonym: "O-glycosylserine" EXACT RESID-alternate [] +synonym: "O-mannopyranosylserine" EXACT RESID-alternate [] +synonym: "O-mannosyl-L-serine" EXACT RESID-name [] +synonym: "O3-mannosylserine" EXACT RESID-alternate [] +synonym: "OManSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 9 H 15 N 1 O 7" +xref: MassAvg: "249.22" +xref: MassMono: "249.084852" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine +is_a: MOD:00595 ! mannosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) + +[Term] +id: MOD:00811 +name: O-mannosyl-L-threonine +def: "a protein modification that effectively forms a O3-mannosylthreonine" [PubMed:391559, RESID:AA0403] +synonym: "(2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Man)" EXACT UniProt-feature [] +synonym: "O-glycosylthreonine" EXACT RESID-alternate [] +synonym: "O-mannosyl-L-threonine" EXACT RESID-name [] +synonym: "O3-mannosylthreonine" EXACT RESID-alternate [] +synonym: "OManThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 10 H 17 N 1 O 7" +xref: MassAvg: "263.25" +xref: MassMono: "263.100502" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00595 ! mannosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:01348 ! O-hexosylated threonine + +[Term] +id: MOD:00812 +name: O-fucosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to an O-fucosylserine." [PubMed:10734111, PubMed:11067851, PubMed:11344537, PubMed:12096136, PubMed:1517205, PubMed:15189151, PubMed:1904059, PubMed:3311742, PubMed:3578767, RESID:AA0404, UniMod:295#S] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (dHex)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Fuc)" EXACT UniProt-feature [] +synonym: "dHex" RELATED PSI-MS-label [] +synonym: "Fucose" RELATED UniMod-description [] +synonym: "O-fucosyl-L-serine" EXACT RESID-name [] +synonym: "O-glycosylserine" EXACT RESID-alternate [] +synonym: "O3-fucosylserine" EXACT RESID-alternate [] +synonym: "OFucSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "146.14" +xref: DiffFormula: "C 6 H 10 N 0 O 4" +xref: DiffMono: "146.057909" +xref: Formula: "C 9 H 15 N 1 O 6" +xref: MassAvg: "233.22" +xref: MassMono: "233.089937" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine +is_a: MOD:00614 ! fucosylated + +[Term] +id: MOD:00813 +name: O-fucosyl-L-threonine +def: "A protein modification that effectively converts an threonine residue to an O-fucosylthreonine." [PubMed:11344537, PubMed:11857757, PubMed:15189151, PubMed:1740125, PubMed:1900431, RESID:AA0405, UniMod:295#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (dHex)" EXACT UniProt-feature [] +synonym: "CARBOHYD O-linked (Fuc)" EXACT UniProt-feature [] +synonym: "dHex" RELATED PSI-MS-label [] +synonym: "Fucose" RELATED UniMod-description [] +synonym: "O-fucosyl-L-threonine" EXACT RESID-name [] +synonym: "O-glycosylthreonine" EXACT RESID-alternate [] +synonym: "O3-fucosylthreonine" EXACT RESID-alternate [] +synonym: "OFucThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "146.14" +xref: DiffFormula: "C 6 H 10 N 0 O 4" +xref: DiffMono: "146.057909" +xref: Formula: "C 10 H 17 N 1 O 6" +xref: MassAvg: "247.25" +xref: MassMono: "247.105587" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00005 ! O-glycosyl-L-threonine +is_a: MOD:00614 ! fucosylated + +[Term] +id: MOD:00814 +name: O-xylosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-xylosylserine." [PubMed:8747463, RESID:AA0406] +comment: One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG]. +synonym: "(2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "O-(beta-D-xylopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O-glycosylserine" EXACT RESID-alternate [] +synonym: "O-xylosyl-L-serine" EXACT RESID-name [] +synonym: "O3-xylosylserine" EXACT RESID-alternate [] +synonym: "OXylSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "132.12" +xref: DiffFormula: "C 5 H 8 N 0 O 4" +xref: DiffMono: "132.042259" +xref: Formula: "C 8 H 13 N 1 O 6" +xref: MassAvg: "219.19" +xref: MassMono: "219.074287" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:00815 +name: molybdopterin +def: "OBSOLETE because redundant with MOD:00151. Remap to MOD:00151." [PubMed:14527393, PubMed:7878465, PubMed:9428520] +xref: DiffAvg: "520.27" +xref: DiffFormula: "C 10 H 11 Mo 1 N 5 O 8 P 1 S 2" +xref: DiffMono: "521.884074" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00816 +name: S-stearoyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine." [DeltaMass:0, PubMed:2371783, PubMed:3143715, PubMed:8761467, RESID:AA0407] +comment: From DeltaMass: Average Mass: 266 +subset: PSI-MOD-slim +synonym: "(R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(octadecanoylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "cysteine octadecanoate thioester" EXACT RESID-alternate [] +synonym: "cysteine stearate thioester" EXACT RESID-alternate [] +synonym: "LIPID S-stearoyl cysteine" EXACT UniProt-feature [] +synonym: "S-stearoyl-L-cysteine" EXACT RESID-name [] +synonym: "SSteCys" EXACT PSI-MOD-label [] +synonym: "Stearoylation" EXACT DeltaMass-label [] +xref: DiffAvg: "266.47" +xref: DiffFormula: "C 18 H 34 N 0 O 1 S 0" +xref: DiffMono: "266.260966" +xref: Formula: "C 21 H 39 N 1 O 2 S 1" +xref: MassAvg: "369.61" +xref: MassMono: "369.270150" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00672 ! S-acylated residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00817 +name: 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan." [ChEBI:35304, PubMed:16407988, PubMed:8168130, RESID:AA0408] +synonym: "(2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan" EXACT RESID-alternate [] +synonym: "3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan" EXACT RESID-name [] +synonym: "3'Ger2'N2cycTrp" EXACT PSI-MOD-label [] +synonym: "LIPID 3'-geranyl-2',N2-cyclotryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "136.24" +xref: DiffFormula: "C 10 H 16 N 0 O 0" +xref: DiffMono: "136.125201" +xref: Formula: "C 21 H 26 N 2 O 1" +xref: MassAvg: "322.45" +xref: MassMono: "322.204513" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:01115 ! isoprenylated tryptophan + +[Term] +id: MOD:00818 +name: glycosylphosphatidylinositolated residue +def: "A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated." [PubMed:12643538, UniMod:394#C-term] +synonym: "glycosylphosphatidylinositol" RELATED UniMod-description [] +synonym: "GPIanchor" RELATED UniMod-interim [] +synonym: "GPIRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00764 ! glycoconjugated residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:00819 +name: L-2-aminobutanoic acid (Glu) +def: "A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid." [ChEBI:35619, DeltaMass:0, PubMed:11740505, RESID:AA0409] +synonym: "(S)-2-aminobutanoic acid" EXACT RESID-systematic [] +synonym: "Abu" EXACT DeltaMass-label [] +synonym: "Abu" EXACT PSI-MOD-label [] +synonym: "alpha-amino-n-butyric acid" EXACT PSI-MOD-alternate [] +synonym: "alpha-aminobutyric acid" EXACT PSI-MOD-alternate [] +synonym: "butyrine" EXACT PSI-MOD-alternate [] +synonym: "dCbxGlu" EXACT PSI-MOD-alternate [] +synonym: "L-2-amino-n-butyric acid" EXACT RESID-alternate [] +synonym: "L-2-aminobutanoic acid" EXACT RESID-name [] +synonym: "L-2-aminobutyric acid" EXACT RESID-alternate [] +synonym: "L-alpha-amino-n-butyric acid" EXACT RESID-alternate [] +synonym: "L-alpha-aminobutyric acid" EXACT RESID-alternate [] +synonym: "L-butyrine" EXACT RESID-alternate [] +xref: DiffAvg: "-44.01" +xref: DiffFormula: "C -1 H 0 N 0 O -2" +xref: DiffMono: "-43.989829" +xref: Formula: "C 4 H 7 N 1 O 1" +xref: MassAvg: "85.11" +xref: MassMono: "85.052764" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00820 +name: 2-imino-alanine 5-imidazolinone glycine +def: "A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine." [PubMed:16627946, RESID:AA0410] +comment: Cross-link 2; carboxamidine. +synonym: "(2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] +synonym: "2,N-didehydroalanyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] +synonym: "2-imino-alanine 5-imidazolinone glycine" EXACT RESID-name [] +synonym: "2-imino-alanyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "[2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] +synonym: "alanyl-5-imidazolinone glycine" EXACT RESID-alternate [] +synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] +synonym: "red fluorescent protein zRFP574 chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "-64.04" +xref: DiffFormula: "C -1 H -4 N 0 O -3" +xref: DiffMono: "-64.016044" +xref: Formula: "C 5 H 4 N 2 O 1" +xref: MassAvg: "108.10" +xref: MassMono: "108.032363" +xref: Origin: "D, G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) + +[Term] +id: MOD:00821 +name: S-(L-alanyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine." [PubMed:11807079, RESID:AA0411] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "alanine cysteine thioester" EXACT RESID-alternate [] +synonym: "CROSSLNK Alanyl cysteine thioester (Cys-Ala)" EXACT UniProt-feature [] +synonym: "S-(2-aminopropanoyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(L-alanyl)-L-cysteine" EXACT RESID-name [] +synonym: "XLNK1AlaSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 9 N 2 O 2 S 1" +xref: MassAvg: "173.21" +xref: MassMono: "173.038474" +xref: Origin: "A, C" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00822 +name: S-(L-leucyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine." [PubMed:12591958, RESID:AA0412] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Leucyl cysteine thioester (Cys-Leu)" EXACT UniProt-feature [] +synonym: "leucine cysteine thioester" EXACT RESID-alternate [] +synonym: "S-(2-amino-4-methylpentanoyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(L-leucyl)-L-cysteine" EXACT RESID-name [] +synonym: "XLNK1LeuSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 9 H 15 N 2 O 2 S 1" +xref: MassAvg: "215.29" +xref: MassMono: "215.085424" +xref: Origin: "C, L" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00911 ! modified L-leucine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00823 +name: S-(L-methionyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine." [PubMed:12146974, RESID:AA0413] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Methionyl cysteine thioester (Cys-Met)" EXACT UniProt-feature [] +synonym: "methionine cysteine thioester" EXACT RESID-alternate [] +synonym: "S-(2-amino-4-methylthiobutanoyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(L-methionyl)-L-cysteine" EXACT RESID-name [] +synonym: "XLNK1MetSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 8 H 13 N 2 O 2 S 2" +xref: MassAvg: "233.32" +xref: MassMono: "233.041845" +xref: Origin: "C, M" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00824 +name: dehydroalanine (Tyr) +def: "A protein modification that effectively converts an L-tyrosine residue to dehydroalanine." [PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:6838602, PubMed:7947813, PubMed:8239649, RESID:AA0181#TYR, UniMod:400] +comment: incidental to RESID:AA0178 +synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] +synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] +synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "anhydroserine" EXACT RESID-alternate [] +synonym: "dehydroalanine" EXACT RESID-name [] +synonym: "Dha" EXACT RESID-alternate [] +synonym: "dHAla(Tyr)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-94.11" +xref: DiffFormula: "C -6 H -6 N 0 O -1" +xref: DiffMono: "-94.041865" +xref: Formula: "C 3 H 3 N 1 O 1" +xref: MassAvg: "69.06" +xref: MassMono: "69.021464" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01168 ! dehydroalanine + +[Term] +id: MOD:00825 +name: S-(L-phenylalanyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine." [PubMed:12591958, RESID:AA0414] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe)" EXACT UniProt-feature [] +synonym: "phenylalanine cysteine thioester" EXACT RESID-alternate [] +synonym: "S-(2-amino-3-phenylpropanoyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(L-phenylalanyl)-L-cysteine" EXACT RESID-name [] +synonym: "XLNK1PheSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 12 H 13 N 2 O 2 S 1" +xref: MassAvg: "249.31" +xref: MassMono: "249.069774" +xref: Origin: "C, F" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00826 +name: S-(L-threonyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine." [PubMed:15268951, RESID:AA0415] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Threonyl cysteine thioester (Cys-Thr)" EXACT UniProt-feature [] +synonym: "S-(2-amino-3-hydroxybutanoyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(L-threonyl)-L-cysteine" EXACT RESID-name [] +synonym: "threonine cysteine thioester" EXACT RESID-alternate [] +synonym: "XLNK1ThrSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 11 N 2 O 3 S 1" +xref: MassAvg: "203.24" +xref: MassMono: "203.049038" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00827 +name: S-(L-tyrosyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine." [PubMed:11807079, RESID:AA0416] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr)" EXACT UniProt-feature [] +synonym: "S-(L-tyrosyl)-L-cysteine" EXACT RESID-name [] +synonym: "S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine" EXACT RESID-alternate [] +synonym: "tyrosine cysteine thioester" EXACT RESID-alternate [] +synonym: "XLNK1TyrSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 12 H 13 N 2 O 3 S 1" +xref: MassAvg: "265.31" +xref: MassMono: "265.064688" +xref: Origin: "C, Y" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00828 +name: S-(L-tryptophanyl)-L-cysteine +def: "A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine." [PubMed:16030216, RESID:AA0417] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp)" EXACT UniProt-feature [] +synonym: "S-(L-tryptophanyl)-L-cysteine" EXACT RESID-name [] +synonym: "S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine" EXACT RESID-alternate [] +synonym: "tryptophan cysteine thioester" EXACT RESID-alternate [] +synonym: "XLNK1TrpSCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 14 H 14 N 3 O 2 S 1" +xref: MassAvg: "288.35" +xref: MassMono: "288.080673" +xref: Origin: "C, W" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00918 ! modified L-tryptophan residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00829 +name: O-(L-phenylalanyl)-L-serine +def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine." [PubMed:12591958, RESID:AA0418] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Phenylalanyl serine ester (Ser-Phe)" EXACT UniProt-feature [] +synonym: "O-(2-amino-3-phenylpropanoyl)serine" EXACT RESID-alternate [] +synonym: "O-(L-phenylalanyl)-L-serine" EXACT RESID-name [] +synonym: "phenylalanine serine ester" EXACT RESID-alternate [] +synonym: "XLNK1PheOSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 12 H 13 N 2 O 3" +xref: MassAvg: "233.25" +xref: MassMono: "233.092617" +xref: Origin: "F, S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00885 ! ester crosslinked residues +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00830 +name: N-methyl-L-proline +def: "A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline." [PubMed:3127388, RESID:AA0419] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +subset: PSI-MOD-slim +synonym: "(S)-1-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "1-methylpyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] +synonym: "hygric acid" EXACT RESID-alternate [] +synonym: "MOD_RES N-methylproline" EXACT UniProt-feature [] +synonym: "N-methyl-L-proline" EXACT RESID-name [] +synonym: "N-methylated L-proline" EXACT PSI-MOD-alternate [] +synonym: "NMePro" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 10 N 1 O 1" +xref: MassAvg: "112.15" +xref: MassMono: "112.076239" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01417 ! monomethylated proline +is_a: MOD:01462 ! N-methylated proline +is_a: MOD:01680 ! alpha-amino monomethylated residue + +[Term] +id: MOD:00831 +name: N4-(N-acetylamino)glucosyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine." [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var] +subset: PSI-MOD-slim +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "N4GlcNAcAsn" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 12 H 19 N 3 O 7" +xref: MassAvg: "317.30" +xref: MassMono: "317.122300" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00448 ! N-acetylaminoglucosylated residue +is_a: MOD:01674 ! N4-(N-acetylamino)hexosyl-L-asparagine + +[Term] +id: MOD:00832 +name: N4-(N-acetylamino)galactosyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine." [PubMed:8262914, RESID:AA0420] +synonym: "(2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-(N-acetylamino)galactosyl-L-asparagine" EXACT RESID-name [] +synonym: "N4-(N-acetylgalactosaminyl)asparagine" EXACT RESID-alternate [] +synonym: "N4-asparagine-beta-N-acetylgalactosaminide" EXACT RESID-alternate [] +synonym: "N4-glycosyl-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-glycosylasparagine" EXACT RESID-alternate [] +synonym: "N4GalNAcAsn" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 12 H 19 N 3 O 7" +xref: MassAvg: "317.30" +xref: MassMono: "317.122300" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00563 ! N-acetylaminogalactosylated residue +is_a: MOD:01674 ! N4-(N-acetylamino)hexosyl-L-asparagine + +[Term] +id: MOD:00833 +name: N4-glucosyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine." [PubMed:1569073, PubMed:3410849, RESID:AA0421] +synonym: "(2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD N-linked (Glc)" EXACT UniProt-feature [] +synonym: "N4-(D-glucopyranosyl)-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-asparagine-glucoside" EXACT RESID-alternate [] +synonym: "N4-glucosyl-L-asparagine" EXACT RESID-name [] +synonym: "N4-glucosylasparagine" EXACT RESID-alternate [] +synonym: "N4-glycosyl-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-glycosylasparagine" EXACT RESID-alternate [] +synonym: "N4GlcAsn" EXACT PSI-MOD-label [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 10 H 16 N 2 O 7" +xref: MassAvg: "276.25" +xref: MassMono: "276.095751" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00433 ! glucosylated residue +is_a: MOD:00761 ! monohexosylated (Hex1) +is_a: MOD:01346 ! N4-hexosylated asparagine + +[Term] +id: MOD:00834 +name: O-(N-acetylamino)fucosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine." [PubMed:11342554, PubMed:12010970, RESID:AA0422] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O-(N-acetylamino)fucosyl-L-serine" EXACT RESID-name [] +synonym: "O-(N-acetylfucosaminyl)serine" EXACT RESID-alternate [] +synonym: "O-seryl-beta-N-acetylfucosaminide" EXACT RESID-alternate [] +synonym: "O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-(N-acetylfucosaminyl)serine" EXACT RESID-alternate [] +synonym: "OFucNAcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "187.19" +xref: DiffFormula: "C 8 H 13 N 1 O 4" +xref: DiffMono: "187.084458" +xref: Formula: "C 11 H 18 N 2 O 6" +xref: MassAvg: "274.27" +xref: MassMono: "274.116486" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:00835 +name: L-3-oxoalanine (Ser) +def: "A protein modification that effectively converts an L-serine residue to L-oxoalanine." [DeltaMass:349, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9276974, PubMed:9478923, RESID:AA0185#SER, UniMod:401#S] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate [] +synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer [] +synonym: "dehydrogenated serine residue" RELATED UniMod-description [] +synonym: "Didehydro" RELATED PSI-MS-label [] +synonym: "formylglycine" RELATED UniMod-alternate [] +synonym: "formylglycine (from serine)" EXACT DeltaMass-label [] +synonym: "L-3-oxoalanine" EXACT RESID-name [] +synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate [] +synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate [] +synonym: "L-serinesemialdehyde" RELATED RESID-misnomer [] +synonym: "MOD_RES 3-oxoalanine (Ser)" EXACT UniProt-feature [] +synonym: "oxoalanine" RELATED UniMod-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 3 H 3 N 1 O 2" +xref: MassAvg: "85.06" +xref: MassMono: "85.016378" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01169 ! L-3-oxoalanine +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:00836 +name: deuterium disubstituted residue +def: "A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "D(H)2Res" EXACT PSI-MOD-label [] +is_a: MOD:00786 ! deuterium substituted residue + +[Term] +id: MOD:00837 +name: deuterium tetrasubstituted residue +def: "A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms." [PubMed:18688235] +synonym: "D(H)4Res" EXACT PSI-MOD-label [] +is_a: MOD:00786 ! deuterium substituted residue + +[Term] +id: MOD:00838 +name: 3x(2)H labeled L-leucine +def: "A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine." [UniMod:262#L] +synonym: "D(H)3Leu" EXACT PSI-MOD-label [] +synonym: "Label:2H(3)" RELATED PSI-MS-label [] +synonym: "Trideuteration" RELATED UniMod-description [] +xref: DiffAvg: "3.02" +xref: DiffFormula: "(1)H -3 (2)H 3" +xref: DiffMono: "3.018830" +xref: Formula: "C 6 (1)H 8 (2)H 3 N 1 O 1" +xref: MassAvg: "116.10" +xref: MassMono: "116.102894" +xref: Origin: "L" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00585 ! deuterium trisubstituted residue +is_a: MOD:00911 ! modified L-leucine residue + +[Term] +id: MOD:00839 +name: (2)H deuterium labeled residue +def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00702 ! isotope labeled residue + +[Term] +id: MOD:00840 +name: isocyanate reagent derivatized residue +def: "A protein modification produced by formation of an adduct with an isocyanate compound." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00841 +name: isothiocyanate reagent derivatized residue +def: "A protein modification produced by formation of an adduct with an isothiocyanate compound." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00842 +name: (13)C labeled residue +def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00702 ! isotope labeled residue + +[Term] +id: MOD:00843 +name: (15)N labeled residue +def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00702 ! isotope labeled residue + +[Term] +id: MOD:00844 +name: (18)O labeled residue +def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00702 ! isotope labeled residue + +[Term] +id: MOD:00845 +name: (18)O substituted residue +def: "A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00844 ! (18)O labeled residue + +[Term] +id: MOD:00846 +name: levuglandinyl (prostaglandin H2) adduct +def: "stub" [PubMed:18688235] +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00847 +name: (18)O disubstituted residue +def: "A protein modification that effectively substitutes two (18)O atom for two (16)O atoms." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00845 ! (18)O substituted residue + +[Term] +id: MOD:00848 +name: reagent derivatized residue +def: "A protein modification that is produced by formation of an adduct with a particular compound used as a reagent." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00849 +name: potassium containing modified residue +def: "A protein modification that effectively substitutes a potassium atom for a hydrogen atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "KRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:00850 +name: unnatural residue +def: "A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00851 +name: (18)O labeled deamidated residue +def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00400 ! deamidated residue +is_a: MOD:00844 ! (18)O labeled residue + +[Term] +id: MOD:00852 +name: 1x(18)O labeled deamidated residue +def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O." [PubMed:8382902, UniMod:366] +subset: PSI-MOD-slim +xref: DiffAvg: "2.99" +xref: DiffFormula: "H -1 N -1 (18)O 1" +xref: DiffMono: "2.988262" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00851 ! (18)O labeled deamidated residue + +[Term] +id: MOD:00853 +name: 2x(18)O labeled deamidated residue +def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "4.99" +xref: DiffFormula: "H -1 N -1 (16)O -1 (18)O 2" +xref: DiffMono: "4.992508" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00851 ! (18)O labeled deamidated residue + +[Term] +id: MOD:00854 +name: protonated L-lysine (L-lysinium) residue +def: "A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine)." [PubMed:18688235] +comment: Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative. +subset: PSI-MOD-slim +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 13 N 2 O 1" +xref: MassAvg: "129.18" +xref: MassMono: "129.102239" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01699 ! protonated residue + +[Term] +id: MOD:00855 +name: N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue) +def: "A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine." [DeltaMass:0, OMSSA:15, PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, UniMod:37#K] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "N6Me3Lys" EXACT PSI-MOD-label [] +synonym: "trimethylk" EXACT OMSSA-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0" +xref: DiffMono: "42.046402" +xref: FormalCharge: "1+" +xref: Formula: "C 9 H 19 N 2 O 1" +xref: MassAvg: "171.26" +xref: MassMono: "171.149190" +xref: Origin: "MOD:00854" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00430 ! trimethylated residue +relationship: derives_from MOD:00854 ! protonated L-lysine (L-lysinium) residue + +[Term] +id: MOD:00856 +name: protonated L-alanine (L-alaninium) residue +def: "A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine)." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "C 3 H 7 N 1 O 1" +xref: MassAvg: "73.09" +xref: MassMono: "73.052215" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01700 ! alpha-amino protonated residue + +[Term] +id: MOD:00857 +name: N,N,N-trimethyl-L-alanine (from L-alaninium) +def: "A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine." [PubMed:12590383, PubMed:332162, PubMed:3979397, PubMed:6778808, PubMed:7715456, UniMod:37#A] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "N2Me3Ala" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0" +xref: DiffMono: "42.046402" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 13 N 1 O 1" +xref: MassAvg: "115.18" +xref: MassMono: "115.099165" +xref: Origin: "MOD:00856" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01687 ! alpha-amino trimethylated residue +relationship: derives_from MOD:00856 ! protonated L-alanine (L-alaninium) residue + +[Term] +id: MOD:00858 +name: D-alanine (Ser) +def: "A protein modification that effectively converts an L-serine residue to D-alanine." [PubMed:7961627, RESID:AA0191#SER] +synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "D-Ala(Ser)" EXACT PSI-MOD-label [] +synonym: "D-alanine" EXACT RESID-name [] +synonym: "MOD_RES D-alanine (Ser)" EXACT UniProt-feature [] +xref: DiffAvg: "-16.00" +xref: DiffFormula: "C 0 H 0 N 0 O -1" +xref: DiffMono: "-15.994915" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00862 ! D-alanine +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01161 ! deoxygenated residue + +[Term] +id: MOD:00859 +name: modified residue that can arise from different natural residues +def: "A protein modification that can be derived from different natural residues by different chemical processes." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00860 +name: sulfur containing modified residue +def: "A protein modification that produces an amino acid residue containing an exogenous sulfur atom." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00861 +name: phosphorus containing modified residue +def: "A protein modification that produces an amino acid residue containing a phosphorus atom." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00862 +name: D-alanine +def: "A protein modification that effectively converts a source amino acid residue to D-alanine." [ChEBI:29949, PubMed:7287302, PubMed:7961627, RESID:AA0191] +synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "D-alanine" EXACT RESID-name [] +synonym: "MOD_RES D-alanine (Ala)" EXACT UniProt-feature [] +synonym: "MOD_RES D-alanine (Ser)" EXACT UniProt-feature [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:00863 +name: D-allo-threonine +def: "A protein modification that effectively converts an L-threonine residue to D-allo-threonine." [ChEBI:32826, PubMed:18025465, PubMed:6893271, RESID:AA0199] +synonym: "(2R,3R)-2-amino-3-hydroxybutanoic acid" EXACT RESID-systematic [] +synonym: "D-Thr" EXACT PSI-MOD-label [] +synonym: "D-threonine" EXACT RESID-name [] +synonym: "MOD_RES D-threonine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 4 H 7 N 1 O 2" +xref: MassAvg: "101.10" +xref: MassMono: "101.047678" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:00864 +name: tris-L-cysteinyl L-histidino diiron disulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide." [PubMed:17766439, PubMed:17766440, RESID:AA0438] +comment: Cross-link 4. +synonym: "CDGSH domain iron-sulfur cluster" EXACT RESID-alternate [] +synonym: "di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron)" EXACT RESID-systematic [] +synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] +synonym: "METAL Iron-sulfur (2Fe-2S); via pros nitrogen" EXACT UniProt-feature [] +synonym: "tris-L-cysteinyl L-histidino diiron disulfide" EXACT RESID-name [] +xref: DiffAvg: "171.78" +xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" +xref: DiffMono: "171.783814" +xref: FormalCharge: "2-" +xref: Formula: "C 15 Fe 2 H 18 N 6 O 4 S 5" +xref: MassAvg: "618.34" +xref: MassMono: "617.870280" +xref: Origin: "C, C, C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:00865 +name: N-aspartyl-glycosylsphingolipidinositolethanolamine +def: "A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine." [RESID:AA0439] +synonym: "GSIAsp" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-like-anchor amidated aspartate" EXACT UniProt-feature [] +synonym: "N-aspartyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 6 H 12 N 2 O 7 P 1" +xref: MassAvg: "255.14" +xref: MassMono: "255.038212" +xref: Origin: "D" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00466 ! glycosylsphingolipidinositolated residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:00866 +name: dihydroxylated proline +def: "A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline." [PubMed:18688235] +synonym: "Hy2Pro" EXACT PSI-MOD-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:00678 ! hydroxylated proline + +[Term] +id: MOD:00867 +name: L-cysteinyl-L-selenocysteine (Cys-Cys) +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine." [PubMed:10801974, PubMed:12911312, PubMed:17177418, RESID:AA0358#CYS] +comment: Cross-link 2. +synonym: "(R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Cysteinyl-selenocysteine (Cys-Sec)" EXACT UniProt-feature [] +synonym: "CROSSLNK Cysteinyl-selenocysteine (Sec-Cys)" EXACT UniProt-feature [] +synonym: "L-cysteinyl-L-selenocysteine" EXACT RESID-name [] +xref: DiffAvg: "44.90" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1 Se 1" +xref: DiffMono: "45.928800" +xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1" +xref: MassAvg: "251.17" +xref: MassMono: "251.947170" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00007 ! selenium substitution for sulfur +is_a: MOD:01627 ! L-cysteinyl-L-selenocysteine + +[Term] +id: MOD:00868 +name: natural, non-standard encoded residue +def: "A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine." [PubMed:18688235] +comment: These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications. +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "natural" +is_a: MOD:00009 ! natural residue + +[Term] +id: MOD:00869 +name: L-alanine residue (Asp) +def: "A protein modification that effectively converts an L-aspartic acid residue to L-alanine." [PubMed:17138938, RESID:AA0001#ASP] +comment: This has been reported to occur by a natural process of beta-decarboxylation. +synonym: "(2S)-2-aminopropanoic acid" EXACT RESID-systematic [] +synonym: "2-aminopropionic acid" EXACT RESID-alternate [] +synonym: "2-azanylpropanoic acid" EXACT RESID-alternate [] +synonym: "alpha-alanine" EXACT RESID-alternate [] +synonym: "alpha-aminopropionic acid" EXACT RESID-alternate [] +synonym: "Asp(Ala)" EXACT PSI-MOD-label [] +synonym: "L-alanine" EXACT RESID-name [] +synonym: "MOD_RES Beta-decarboxylated aspartate" EXACT UniProt-feature [] +xref: DiffAvg: "-44.01" +xref: DiffFormula: "C -1 H 0 N 0 O -2" +xref: DiffMono: "-43.989829" +xref: Formula: "C 3 H 5 N 1 O 1" +xref: MassAvg: "71.08" +xref: MassMono: "71.037114" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00010 ! L-alanine residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:00870 +name: phenyl isocyanate derivatized residue +def: "A protein modification produced by formation of an adduct with phenyl isocyanate." [UniMod:411] +comment: From UniMod with no citation. +subset: PSI-MOD-slim +synonym: "phenyl isocyanate" RELATED UniMod-description [] +synonym: "Phenylisocyanate" RELATED PSI-MS-label [] +xref: DiffAvg: "119.12" +xref: DiffFormula: "C 7 H 5 N 1 O 1" +xref: DiffMono: "119.037114" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00840 ! isocyanate reagent derivatized residue + +[Term] +id: MOD:00871 +name: (2)H5-phenyl isocyanate derivatized residue +def: "A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate." [UniMod:412] +comment: From UniMod with no citation. +subset: PSI-MOD-slim +synonym: "d5-phenyl isocyanate" RELATED UniMod-description [] +synonym: "Phenylisocyanate:2H(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "124.07" +xref: DiffFormula: "C 7 (2)H 5 N 1 O 1" +xref: DiffMono: "124.068498" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00870 ! phenyl isocyanate derivatized residue +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00872 +name: L-isoglutamyl monoglutamic acid +def: "OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970." [PubMed:10747868, PubMed:15525938, PubMed:1680872, RESID:AA0202#var, UniMod:450] +synonym: "Glu" RELATED UniMod-interim [] +synonym: "monoglutamyl" RELATED UniMod-description [] +synonym: "N alpha -(gamma-Glutamyl)-Glu" EXACT DeltaMass-label [] +xref: DiffAvg: "129.12" +xref: DiffFormula: "C 5 H 7 N 1 O 3" +xref: DiffMono: "129.042593" +xref: Formula: "C 10 H 14 N 2 O 6" +xref: MassAvg: "258.23" +xref: MassMono: "258.085186" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00873 +name: L-isoglutamyl diglutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid." [DeltaMass:0, PubMed:10747868, PubMed:1680872, RESID:AA0202#var, UniMod:451] +synonym: "diglutamyl" RELATED UniMod-description [] +synonym: "GluGlu" RELATED UniMod-interim [] +xref: DiffAvg: "258.23" +xref: DiffFormula: "C 10 H 14 N 2 O 6" +xref: DiffMono: "258.085186" +xref: Formula: "C 15 H 21 N 3 O 9" +xref: MassAvg: "387.35" +xref: MassMono: "387.127779" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid + +[Term] +id: MOD:00874 +name: L-isoglutamyl triglutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid." [DeltaMass:0, PubMed:10747868, PubMed:1680872, RESID:AA0202#var, UniMod:452] +comment: From DeltaMass: Average Mass: 388. +synonym: "GluGluGlu" RELATED UniMod-interim [] +synonym: "N alpha -(gamma-Glutamyl)-Glu3" EXACT DeltaMass-label [] +synonym: "triglutamyl" RELATED UniMod-description [] +xref: DiffAvg: "387.35" +xref: DiffFormula: "C 15 H 21 N 3 O 9" +xref: DiffMono: "387.127779" +xref: Formula: "C 20 H 28 N 4 O 12" +xref: MassAvg: "516.46" +xref: MassMono: "516.170372" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid + +[Term] +id: MOD:00875 +name: L-isoglutamyl tetraglutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid." [PubMed:10747868, PubMed:1680872, RESID:AA0202#var, UniMod:453] +synonym: "GluGluGluGlu" RELATED UniMod-interim [] +synonym: "tetraglutamyl" RELATED UniMod-description [] +xref: DiffAvg: "516.46" +xref: DiffFormula: "C 20 H 28 N 4 O 12" +xref: DiffMono: "516.170372" +xref: Formula: "C 25 H 35 N 5 O 15" +xref: MassAvg: "645.57" +xref: MassMono: "645.212965" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid + +[Term] +id: MOD:00876 +name: hexosaminylated residue +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond." [UniMod:454] +synonym: "HexN" RELATED PSI-MS-label [] +synonym: "Hexosamine" RELATED UniMod-description [] +synonym: "Hexosamines (GalN, GlcN)" EXACT DeltaMass-label [] +xref: DiffAvg: "161.16" +xref: DiffFormula: "C 6 H 11 N 1 O 4" +xref: DiffMono: "161.068808" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00877 +name: imidoester crosslink dimethyl pimelimidate singly attached +def: "dimethyl pimelimidate modification from UniMod" [UniMod:455, URL:http\://www.piercenet.com/files/0668ss5.pdf] +synonym: "One end of crosslink attached, one end free" RELATED UniMod-description [] +synonym: "Xlink:DMP-s" RELATED UniMod-interim [] +xref: DiffAvg: "154.21" +xref: DiffFormula: "C 8 H 14 N 2 O 1" +xref: DiffMono: "154.110613" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00878 +name: imidoester crosslink dimethyl pimelimidate doubly attached +def: "dimethyl pimelimidate modification from UniMod - Mechanism of the reaction of imidoesters with amines" [PubMed:7171546, UniMod:456, URL:http\://dx.doi.org/10.1021/ja00877a017] +synonym: "Both ends of crosslink attached to same peptide" RELATED UniMod-description [] +synonym: "Xlink:DMP" RELATED UniMod-interim [] +xref: DiffAvg: "122.17" +xref: DiffFormula: "C 7 H 10 N 2" +xref: DiffMono: "122.084398" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00879 +name: naphthalene-2,3-dicarboxaldehyde +def: "modification from UniMod" [PubMed:2081203, UniMod:457] +synonym: "naphthalene-2,3-dicarboxaldehyde" RELATED UniMod-description [] +synonym: "NDA" RELATED UniMod-interim [] +xref: DiffAvg: "175.19" +xref: DiffFormula: "C 13 H 5 N 1" +xref: DiffMono: "175.042199" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00880 +name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue +def: "A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate." [PubMed:15536630, PubMed:16526082, UniMod:464] +synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED UniMod-description [] +synonym: "SPITC:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "220.99" +xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2" +xref: DiffMono: "220.991214" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue +is_a: MOD:01428 ! (13)C isotope tagged reagent + +[Term] +id: MOD:00881 +name: N-reductive amination-D +def: "OBSOLETE because UniMod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D." [PubMed:9252331, UniMod:465] +xref: DiffAvg: "32.06" +xref: DiffFormula: "C 2 (2)H 4" +xref: DiffMono: "32.056407" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00882 +name: S-(2-aminoethyl)cysteine (Ser) +def: "A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine." [DeltaMass:171, PubMed:12923550, UniMod:472#S] +comment: From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. +synonym: "AEC-MAEC" RELATED UniMod-interim [] +synonym: "Aminoethyl Cysteinyl (AECys)" EXACT DeltaMass-label [] +synonym: "aminoethylcysteine" RELATED UniMod-description [] +xref: DiffAvg: "59.13" +xref: DiffFormula: "C 2 H 5 N 1 O -1 S 1" +xref: DiffMono: "59.019356" +xref: Formula: "C 5 H 10 N 2 O 1 S 1" +xref: MassAvg: "146.21" +xref: MassMono: "146.051384" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00883 +name: C1-amidated residue +def: "A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group." [DeltaMass:0, OMSSA:25, UniMod:2] +comment: The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG]. +subset: PSI-MOD-slim +synonym: "alpha-amidated residue" EXACT PSI-MOD-alternate [] +synonym: "Amidated" RELATED PSI-MS-label [] +synonym: "Amidation" RELATED UniMod-description [] +synonym: "Amide formation (C terminus)" EXACT DeltaMass-label [] +synonym: "ctermamide" EXACT OMSSA-label [] +synonym: "ResN" EXACT PSI-MOD-label [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00674 ! amidated residue + +[Term] +id: MOD:00884 +name: S-aminoethylcysteine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine." [PubMed:1175632, PubMed:18688235] +comment: This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine. +subset: PSI-MOD-slim +synonym: "4-thialysine" EXACT PSI-MOD-alternate [] +synonym: "L-cysteine aziridine adduct" EXACT PSI-MOD-alternate [] +synonym: "S-(2-aminoethyl)-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "43.07" +xref: DiffFormula: "C 2 H 5 N 1 O 0 S 0" +xref: DiffMono: "43.042199" +xref: Formula: "C 5 H 10 N 2 O 1 S 1" +xref: MassAvg: "146.21" +xref: MassMono: "146.051384" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00885 +name: ester crosslinked residues +def: "A protein modification that crosslinks two residues by formation of an ester bond." [PubMed:18688235] +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00886 +name: 6'-chloro-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan." [PubMed:9033387, RESID:AA0180, UniMod:936#W] +comment: The UniMod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by UniMod:936 [JSG]. +synonym: "(2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "6'-chloro-L-tryptophan" EXACT RESID-name [] +synonym: "6'-ClTrp" EXACT PSI-MOD-label [] +synonym: "MOD_RES 6'-chlorotryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 11 Cl 1 H 9 N 2 O 1" +xref: MassAvg: "220.66" +xref: MassMono: "220.040341" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01913 ! monochlorinated L-tryptophan + +[Term] +id: MOD:00887 +name: methylated aspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester." [PubMed:18688235] +is_a: MOD:00427 ! methylated residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:00888 +name: protonated L-proline (L-prolinium) residue +def: "A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline)." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 9 N 1 O 1" +xref: MassAvg: "99.13" +xref: MassMono: "99.067865" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01700 ! alpha-amino protonated residue + +[Term] +id: MOD:00889 +name: N,N-dimethyl-L-proline (from L-prolinium) +def: "A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline." [UniMod:36#P] +subset: PSI-MOD-slim +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.030752" +xref: FormalCharge: "1+" +xref: Formula: "C 7 H 13 N 1 O 1" +xref: MassAvg: "127.19" +xref: MassMono: "127.099165" +xref: Origin: "MOD:00888" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00075 ! N,N-dimethyl-L-proline +relationship: derives_from MOD:00888 ! protonated L-proline (L-prolinium) residue + +[Term] +id: MOD:00890 +name: phosphorylated L-histidine +def: "A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine." [OMSSA:192, UniMod:21#H] +subset: PSI-MOD-slim +synonym: "mod192" EXACT OMSSA-label [] +synonym: "NPhosHis" EXACT PSI-MOD-label [] +synonym: "Phospho" RELATED PSI-MS-label [] +synonym: "phosphohistidine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 6 H 8 N 3 O 4 P 1" +xref: MassAvg: "217.12" +xref: MassMono: "217.025242" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01456 ! N-phosphorylated residue + +[Term] +id: MOD:00891 +name: D-serine +def: "A protein modification that effectively converts a source amino acid residue to D-serine." [ChEBI:29998, PubMed:6893271, PubMed:7973665, RESID:AA0195] +synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "D-Ser" EXACT PSI-MOD-label [] +synonym: "D-serine" EXACT RESID-name [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 3 H 5 N 1 O 2" +xref: MassAvg: "87.08" +xref: MassMono: "87.032028" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:00892 +name: D-serine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to D-serine." [PubMed:18025465, PubMed:6893271, RESID:AA0195#CYS] +synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "D-serine" EXACT RESID-name [] +xref: DiffAvg: "-16.06" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S -1" +xref: DiffMono: "-15.977156" +xref: Formula: "C 3 H 5 N 1 O 2" +xref: MassAvg: "87.08" +xref: MassMono: "87.032028" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00891 ! D-serine +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00893 +name: residues isobaric at 128.0-128.1 +def: "Natural or modified residues with a mass of 128.0-128.1 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da + +[Term] +id: MOD:00894 +name: residues isobaric at 128.058578 Da +def: "Natural or modified resiues with a mass of 128.058578 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da +is_a: MOD:00893 ! residues isobaric at 128.0-128.1 + +[Term] +id: MOD:00895 +name: FAD modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00697 ! flavin modified residue +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:00896 +name: FMN modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00697 ! flavin modified residue +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:00897 +name: N-acetyl-S-archeol-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine." [RESID:AA0043#var, RESID:AA0223#var] +xref: DiffAvg: "677.20" +xref: DiffFormula: "C 45 H 88 N 0 O 3 S 0" +xref: DiffMono: "676.673347" +xref: Formula: "C 48 H 93 N 1 O 4 S 1" +xref: MassAvg: "780.34" +xref: MassMono: "779.682531" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +relationship: has_functional_parent MOD:00052 ! N-acetyl-L-cysteine +relationship: has_functional_parent MOD:00228 ! S-diphytanylglycerol diether-L-cysteine + +[Term] +id: MOD:00898 +name: S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107#var, UniMod:377] +comment: Incidental to RESID:AA0060. +synonym: "Diacylglycerol" RELATED PSI-MS-label [] +synonym: "diacylglycerol" RELATED UniMod-description [] +xref: DiffAvg: "576.95" +xref: DiffFormula: "C 37 H 68 N 0 O 4 S 0" +xref: DiffMono: "576.511761" +xref: Formula: "C 40 H 73 N 1 O 5 S 1" +xref: MassAvg: "680.09" +xref: MassMono: "679.520945" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00116 ! S-diacylglycerol-L-cysteine + +[Term] +id: MOD:00899 +name: N-palmitoyl-S-diacylglycerol-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine." [RESID:AA0069#var, RESID:AA0107#var] +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +relationship: has_functional_parent MOD:00069 ! N-palmitoyl-L-cysteine +relationship: has_functional_parent MOD:00116 ! S-diacylglycerol-L-cysteine + +[Term] +id: MOD:00900 +name: N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine." [PubMed:18688235] +synonym: "(R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "815.36" +xref: DiffFormula: "C 53 H 98 N 0 O 5 S 0" +xref: DiffMono: "814.741426" +xref: Formula: "C 56 H 103 N 1 O 6 S 1" +xref: MassAvg: "918.50" +xref: MassMono: "917.750611" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00899 ! N-palmitoyl-S-diacylglycerol-L-cysteine +relationship: has_functional_parent MOD:00069 ! N-palmitoyl-L-cysteine +relationship: has_functional_parent MOD:00898 ! S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine + +[Term] +id: MOD:00901 +name: modified L-alanine residue +def: "A protein modification that modifies an L-alanine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModAla" EXACT PSI-MOD-label [] +xref: Origin: "A" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00902 +name: modified L-arginine residue +def: "A protein modification that modifies an L-arginine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModArg" EXACT PSI-MOD-label [] +xref: Origin: "R" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00903 +name: modified L-asparagine residue +def: "A protein modification that modifies an L-asparagine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModAsn" EXACT PSI-MOD-label [] +xref: Origin: "N" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00904 +name: modified L-aspartic acid residue +def: "A protein modification that modifies an L-aspartic acid residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModAsp" EXACT PSI-MOD-label [] +xref: Origin: "D" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00905 +name: modified L-cysteine residue +def: "A protein modification that modifies an L-cysteine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModCys" EXACT PSI-MOD-label [] +xref: Origin: "C" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00906 +name: modified L-glutamic acid residue +def: "A protein modification that modifies an L-glutamic acid residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModGlu" EXACT PSI-MOD-label [] +xref: Origin: "E" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00907 +name: modified L-glutamine residue +def: "A protein modification that modifies an L-glutamine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModGln" EXACT PSI-MOD-label [] +xref: Origin: "Q" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00908 +name: modified glycine residue +def: "A protein modification that modifies a glycine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModGly" EXACT PSI-MOD-label [] +xref: Origin: "G" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00909 +name: modified L-histidine residue +def: "A protein modification that modifies an L-histidine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModHis" EXACT PSI-MOD-label [] +xref: Origin: "H" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00910 +name: modified L-isoleucine residue +def: "A protein modification that modifies an L-isoleucine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModIle" EXACT PSI-MOD-label [] +xref: Origin: "I" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00911 +name: modified L-leucine residue +def: "A protein modification that modifies an L-leucine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModLeu" EXACT PSI-MOD-label [] +xref: Origin: "L" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00912 +name: modified L-lysine residue +def: "A protein modification that modifies an L-lysine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModLys" EXACT PSI-MOD-label [] +xref: Origin: "K" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00913 +name: modified L-methionine residue +def: "A protein modification that modifies an L-methionine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModMet" EXACT PSI-MOD-label [] +xref: Origin: "M" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00914 +name: modified L-phenylalanine residue +def: "A protein modification that modifies an L-phenylalanine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModPhe" EXACT PSI-MOD-label [] +xref: Origin: "F" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00915 +name: modified L-proline residue +def: "A protein modification that modifies an L-proline residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModPro" EXACT PSI-MOD-label [] +xref: Origin: "P" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00916 +name: modified L-serine residue +def: "A protein modification that modifies an L-serine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModSer" EXACT PSI-MOD-label [] +xref: Origin: "S" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00917 +name: modified L-threonine residue +def: "A protein modification that modifies an L-threonine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModThr" EXACT PSI-MOD-label [] +xref: Origin: "T" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00918 +name: modified L-tryptophan residue +def: "A protein modification that modifies an L-tryptophan residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModTrp" EXACT PSI-MOD-label [] +xref: Origin: "W" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00919 +name: modified L-tyrosine residue +def: "A protein modification that modifies an L-tyrosine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00920 +name: modified L-valine residue +def: "A protein modification that modifies an L-valine residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ModVal" EXACT PSI-MOD-label [] +xref: Origin: "V" +is_a: MOD:01157 ! protein modification categorized by amino acid modified + +[Term] +id: MOD:00921 +name: new uncategorized UniMod entries +def: "New uncategorized UniMod. OBSOLETE because organizational use is no longer required." [PubMed:18688235] +is_obsolete: true + +[Term] +id: MOD:00922 +name: Cy3 CyDye DIGE Fluor saturation dye +def: "modification from UniMod Chemical derivative" [UniMod:494] +synonym: "Cy3 CyDye DIGE Fluor saturation dye" RELATED UniMod-description [] +synonym: "CyDye-Cy3" RELATED UniMod-interim [] +xref: DiffAvg: "672.84" +xref: DiffFormula: "C 37 H 44 N 4 O 6 S 1" +xref: DiffMono: "672.298156" +xref: Formula: "C 40 H 49 N 5 O 7 S 2" +xref: MassAvg: "775.98" +xref: MassMono: "775.307341" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00923 +name: Cy5 CyDye DIGE Fluor saturation dye +def: "modification from UniMod Chemical derivative" [UniMod:495] +synonym: "Cy5 CyDye DIGE Fluor saturation dye" RELATED UniMod-description [] +synonym: "CyDye-Cy5" RELATED UniMod-interim [] +xref: DiffAvg: "684.85" +xref: DiffFormula: "C 38 H 44 N 4 O 6 S 1" +xref: DiffMono: "684.298156" +xref: Formula: "C 41 H 49 N 5 O 7 S 2" +xref: MassAvg: "787.99" +xref: MassMono: "787.307341" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00924 +name: N6-(L-threonyl)-L-lysine +def: "A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine." [PubMed:18063774, RESID:AA0440] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "N6-(L-threonyl)-L-lysine" EXACT RESID-name [] +synonym: "N6-threonyl-lysine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 10 H 18 N 3 O 3" +xref: MassAvg: "228.27" +xref: MassMono: "228.134816" +xref: Origin: "K, T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:00925 +name: heptosylated residue +def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond." [UniMod:490] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00693 ! glycosylated residue + +[Term] +id: MOD:00926 +name: Bisphenol A diglycidyl ether derivative +def: "Modification from UniMod Non-standard residue. OBSOLETE because not an amino acid modification. From UniMod not an approved entry." [PubMed:11225353, UniMod:493] +synonym: "BADGE" RELATED UniMod-interim [] +synonym: "Bisphenol A diglycidyl ether derivative" RELATED UniMod-description [] +xref: DiffAvg: "340.42" +xref: DiffFormula: "C 21 H 24 O 4" +xref: DiffMono: "340.167459" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00927 +name: 2x(13)C,4x(2)H labeled dimethylated residue +def: "A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue." [PubMed:16335955, PubMed:3802193, UniMod:510] +synonym: "DiMethyl-C13HD2" RELATED UniMod-description [] +synonym: "Dimethyl:2H(4)13C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "34.06" +xref: DiffFormula: "(13)C 2 (2)H 4" +xref: DiffMono: "34.063117" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00842 ! (13)C labeled residue + +[Term] +id: MOD:00928 +name: [3-(2,5)-dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium +def: "modification from UniMod Chemical derivative" [PubMed:16771548, UniMod:513] +comment: Should have children for K and X-N-term [JSG]. +synonym: "[3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium" RELATED UniMod-description [] +synonym: "C8-QAT" RELATED UniMod-interim [] +xref: DiffAvg: "227.39" +xref: DiffFormula: "C 14 H 29 N 1 O 1" +xref: DiffMono: "227.224915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00929 +name: lactose glycated lysine +def: "A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct." [PubMed:9606156, UniMod:512] +comment: The term lactosylation used with this meaning is a misnomer [JSG]. +synonym: "Hex(2)" RELATED UniMod-interim [] +synonym: "Lactosylation" RELATED UniMod-description [] +xref: DiffAvg: "342.30" +xref: DiffFormula: "C 12 H 22 O 11" +xref: DiffMono: "342.116212" +xref: Formula: "C 18 H 34 N 2 O 12" +xref: MassAvg: "470.47" +xref: MassMono: "470.211175" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00767 ! glycated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00930 +name: propyl-NAG tyrosine adduct +def: "tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline." [PubMed:15795231, UniMod:514] +xref: DiffAvg: "232.27" +xref: DiffFormula: "C 9 H 14 N 1 O 4 S 1" +xref: DiffMono: "232.064354" +xref: Formula: "C 18 H 23 N 2 O 6 S 1" +xref: MassAvg: "395.45" +xref: MassMono: "395.127682" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00931 +name: Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K +def: "modification from UniMod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups" [PubMed:11085420, UniMod:498] +synonym: "BHTOH" RELATED UniMod-interim [] +synonym: "Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K" RELATED UniMod-description [] +xref: DiffAvg: "234.34" +xref: DiffFormula: "C 15 H 22 O 2" +xref: DiffMono: "234.161980" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00932 +name: IDBEST tag for quantitation +def: "modification from UniMod Isotopic label" [PubMed:11821862, UniMod:499] +synonym: "Heavy IDBEST tag for quantitation" RELATED UniMod-description [] +synonym: "IGBP:13C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "298.02" +xref: DiffFormula: "Br 1 (12)C 10 (13)C 2 H 13 N 2 O 2" +xref: DiffMono: "298.022749" +xref: Formula: "Br 1 (12)C 13 (13)C 2 H 18 N 3 O 3 S 1" +xref: MassAvg: "401.03" +xref: MassMono: "401.031934" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:00933 +name: methylglyoxal arginine adduct (+54 amu) +def: "modification from UniMod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu)" [UniMod:319#R] +comment: Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52. +synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] +synonym: "MDA adduct +54" RELATED UniMod-description [] +xref: DiffAvg: "54.05" +xref: DiffFormula: "C 3 H 2 O 1" +xref: DiffMono: "54.010565" +xref: Formula: "C 9 H 14 N 4 O 2" +xref: MassAvg: "210.24" +xref: MassMono: "210.111676" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00630 ! C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00934 +name: Levuglandinyl - arginine hydroxylactam adduct +def: "modification from UniMod Post-translational" [UniMod:506] +synonym: "Levuglandinyl - arginine hydroxylactam adduct" RELATED UniMod-description [] +synonym: "LG-Hlactam-R" RELATED UniMod-interim [] +xref: DiffAvg: "306.40" +xref: DiffFormula: "C 19 H 26 N -2 O 5" +xref: DiffMono: "306.171876" +xref: Formula: "C 25 H 38 N 2 O 6" +xref: MassAvg: "462.59" +xref: MassMono: "462.272987" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00935 +name: methionine oxidation with neutral loss of 64 Da +def: "Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH." [PubMed:18688235, PubMed:9004526] +comment: Originally created from UniMod:507 that was later deleted. +xref: DiffAvg: "-64.10" +xref: DiffFormula: "C -1 H -4 N 0 O -1 S -1" +xref: DiffMono: "-63.998286" +xref: Formula: "C 4 H 5 N 1 O 1 S 0" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00431 ! modified residue with a secondary neutral loss +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:00936 +name: Levuglandinyl - hydroxylactam adduct, K and N-term +def: "modification from UniMod Post-translational" [UniMod:504] +synonym: "Levuglandinyl - lysine hydroxylactam adduct" RELATED UniMod-description [] +synonym: "LG-Hlactam-K" RELATED UniMod-interim [] +xref: DiffAvg: "348.44" +xref: DiffFormula: "C 20 H 28 O 5" +xref: DiffMono: "348.193674" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct + +[Term] +id: MOD:00937 +name: Levuglandinyl - arginine lactam adduct +def: "modification from UniMod Post-translational" [UniMod:505] +synonym: "Levuglandinyl - arginine lactam adduct" RELATED UniMod-description [] +synonym: "LG-lactam-R" RELATED UniMod-interim [] +xref: DiffAvg: "290.40" +xref: DiffFormula: "C 19 H 26 N -2 O 4" +xref: DiffMono: "290.176961" +xref: Formula: "C 25 H 38 N 2 O 5" +xref: MassAvg: "446.59" +xref: MassMono: "446.278072" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:00938 +name: Levuglandinyl - lactam adduct, K and N-term +def: "modification from UniMod Post-translational" [PubMed:12590383, UniMod:503] +synonym: "Levuglandinyl - lysine lactam adduct" RELATED UniMod-description [] +synonym: "LG-lactam-K" RELATED UniMod-interim [] +xref: DiffAvg: "332.44" +xref: DiffFormula: "C 20 H 28 O 4" +xref: DiffMono: "332.198759" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct + +[Term] +id: MOD:00939 +name: hydrolyzed N-methylmaleimide cysteine adduct +def: "modification from UniMod Chemical derivative" [UniMod:500] +synonym: "Nmethylmaleimide+water" RELATED UniMod-interim [] +synonym: "Nmethylmaleimidehydrolysis" RELATED UniMod-description [] +xref: DiffAvg: "129.12" +xref: DiffFormula: "C 5 H 7 N 1 O 3" +xref: DiffMono: "129.042593" +xref: Formula: "C 8 H 12 N 2 O 4 S 1" +xref: MassAvg: "232.25" +xref: MassMono: "232.051778" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00940 +name: 3-methyl-2-pyridyl isocyanate derivatized residue +def: "A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate." [PubMed:11078590, UniMod:501] +synonym: "3-methyl-2-pyridyl isocyanate" RELATED UniMod-description [] +synonym: "PyMIC" RELATED UniMod-interim [] +xref: DiffAvg: "134.14" +xref: DiffFormula: "C 7 H 6 N 2 O 1" +xref: DiffMono: "134.048013" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00840 ! isocyanate reagent derivatized residue + +[Term] +id: MOD:00941 +name: dehydropyrrolizidine alkaloid (dehydroretronecine) derivatized cysteine +def: "modification from UniMod Chemical derivative" [PubMed:12175151, UniMod:488] +synonym: "Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines" RELATED UniMod-description [] +synonym: "DHP" RELATED UniMod-interim [] +xref: DiffAvg: "118.16" +xref: DiffFormula: "C 8 H 8 N 1" +xref: DiffMono: "118.065674" +xref: Formula: "C 11 H 13 N 2 S 1" +xref: MassAvg: "205.30" +xref: MassMono: "205.079944" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00942 +name: (4,4,5,5-(2)H4)-L-lysine +def: "A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine." [OMSSA:180, UniMod:481] +comment: For SILAC experiments. +synonym: "4,4,5,5-D4 Lysine" RELATED UniMod-description [] +synonym: "4,4,5,5-tetradeuterolysine" EXACT PSI-MOD-alternate [] +synonym: "Label:2H(4)" RELATED UniMod-interim [] +synonym: "lys-2H4" EXACT OMSSA-label [] +xref: DiffAvg: "4.03" +xref: DiffFormula: "(1)H -4 (2)H 4" +xref: DiffMono: "4.025107" +xref: Formula: "C 6 (1)H 8 (2)H 4 N 2 O 1" +xref: MassAvg: "132.12" +xref: MassMono: "132.120070" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00837 ! deuterium tetrasubstituted residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:00943 +name: 4-trimethylammoniumbutanoyl derivatized residue +def: "modification from UniMod Isotopic label" [PubMed:12643539, UniMod:476] +synonym: "4-trimethyllammoniumbutyryl-" RELATED UniMod-description [] +synonym: "TMAB" RELATED UniMod-interim [] +xref: DiffAvg: "128.19" +xref: DiffFormula: "C 7 H 14 N 1 O 1" +xref: DiffMono: "128.107539" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00944 +name: d9-4-trimethylammoniumbutanoyl derivatized residue +def: "modification from UniMod Isotopic label" [UniMod:477] +synonym: "d9-4-trimethyllammoniumbutyryl-" RELATED UniMod-description [] +synonym: "TMAB:2H(9)" RELATED UniMod-interim [] +xref: DiffAvg: "137.16" +xref: DiffFormula: "C 7 (1)H 5 (2)H 9 N 1 O 1" +xref: DiffMono: "137.164030" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00943 ! 4-trimethylammoniumbutanoyl derivatized residue +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:00945 +name: fluorescein-5-thiosemicarbazide adduct +def: "OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626." [PubMed:18688235] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00946 +name: crosslinked residues with loss of ammonia +def: "A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00947 +name: DeltaMass +def: "Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all." [PubMed:18688235] +is_a: MOD:00032 ! uncategorized protein modification + +[Term] +id: MOD:00948 +name: 5'-dephospho +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: -79 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00949 +name: desmosine +def: "OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933." [DeltaMass:0] +comment: From DeltaMass: Average Mass: -58 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00950 +name: decomposed carboxymethylated methionine +def: "modification from DeltaMass" [DeltaMass:3] +comment: From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "M" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00951 +name: L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide +def: "Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment." [DeltaMass:58] +comment: From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI. +synonym: "d4CbxGlu" EXACT PSI-MOD-label [] +xref: DiffAvg: "-44.01" +xref: DiffFormula: "C -1 H 0 N 0 O -2" +xref: DiffMono: "-43.989829" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00015 ! L-glutamic acid residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00957 ! modified residue with neutral loss of carbon dioxide +is_a: MOD:00960 ! decarboxylated residue + +[Term] +id: MOD:00952 +name: (2-aminosuccinimidyl)acetic acid (Asp) +def: "A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule." [PubMed:10801322, RESID:AA0441#ASP] +comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue. +subset: PSI-MOD-slim +synonym: "(2-aminosuccinimidyl)acetic acid" EXACT RESID-name [] +synonym: "(3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid" EXACT RESID-alternate [] +synonym: "[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid" EXACT RESID-systematic [] +synonym: "anhydroaspartyl glycine" EXACT RESID-alternate [] +synonym: "aspartimide glycine" EXACT RESID-alternate [] +synonym: "CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly)" EXACT UniProt-feature [] +synonym: "N-(2-aminosuccinyl)glycine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 6 N 2 O 3" +xref: MassAvg: "154.13" +xref: MassMono: "154.037842" +xref: Origin: "D, G" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01628 ! (2-aminosuccinimidyl)acetic acid + +[Term] +id: MOD:00953 +name: O-(L-isoglutamyl)-L-serine (Glu-Ser) +def: "A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine." [DeltaMass:0, PubMed:19035375, RESID:AA0597#ESX] +comment: Cross-link 2; From DeltaMass: with no citation. +synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK isoglutamyl serine ester (Ser-Glu)" EXACT UniProt-feature [] +synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name [] +synonym: "O-gamma-Glutamyl- (Crosslink to Serine)" EXACT DeltaMass-label [] +synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 8 H 10 N 2 O 4" +xref: MassAvg: "198.18" +xref: MassMono: "198.064057" +xref: Origin: "E, S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01977 ! O-(L-isoglutamyl)-L-serine + +[Term] +id: MOD:00954 +name: crosslinked residues with loss of water +def: "A protein modification that crosslinks two residues with a covalent bond and the loss of water." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:00955 +name: alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine) +def: "A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine." [DeltaMass:0] +comment: Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG]. +synonym: "beta-alaninohistidine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 9 H 10 N 4 O 2" +xref: MassAvg: "206.20" +xref: MassMono: "206.080376" +xref: Origin: "H, S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:00956 +name: misincorporation of norleucine for methionine +def: "modification from DeltaMass" [DeltaMass:10] +comment: From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration. +xref: DiffAvg: "-18.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S -1" +xref: DiffMono: "-17.956421" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "M" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01026 ! norleucine residue (Nle) + +[Term] +id: MOD:00957 +name: modified residue with neutral loss of carbon dioxide +def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment." [PubMed:18688235] +synonym: "dCO2ModRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "-44.01" +xref: DiffFormula: "C -1 H 0 N 0 O -2" +xref: DiffMono: "-43.989829" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00431 ! modified residue with a secondary neutral loss + +[Term] +id: MOD:00958 +name: crosslink between Arg and His sidechains +def: "modification from DeltaMass" [DeltaMass:0] +comment: Cross-link 2; From DeltaMass: Average Mass: -5 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "H, R" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00959 +name: 3,3',5,5'-TerTyr (Crosslink) +def: "modification from DeltaMass" [DeltaMass:0] +comment: Cross-link 4; From DeltaMass: Average Mass: -4 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Y, Y, Y, Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues + +[Term] +id: MOD:00960 +name: decarboxylated residue +def: "A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom." [PubMed:18688235] +xref: DiffAvg: "-44.01" +xref: DiffFormula: "C -1 H 0 N 0 O -2" +xref: DiffMono: "-43.989829" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:00961 +name: reduction of disulfide crosslink in cystine to two cysteines +def: "A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues." [DeltaMass:333] +comment: Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine. +subset: PSI-MOD-slim +xref: DiffAvg: "2.02" +xref: DiffFormula: "C 0 H 2 N 0 O 0 S 0" +xref: DiffMono: "2.015650" +xref: Formula: "C 6 H 10 N 2 O 2 S 2" +xref: MassAvg: "206.28" +xref: MassMono: "206.018370" +xref: Origin: "MOD:00034" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01473 ! hydrogenated residue +relationship: derives_from MOD:00034 ! L-cystine (cross-link) + +[Term] +id: MOD:00962 +name: 2',3'-dihydrotryptophan +def: "A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan." [DeltaMass:343, URL:http\://dx.doi.org/10.1016/S0040-4039(00)99113-5] +comment: From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG]. +xref: DiffAvg: "2.02" +xref: DiffFormula: "C 0 H 2 N 0 O 0 S 0" +xref: DiffMono: "2.015650" +xref: Formula: "C 11 H 12 N 2 O 1" +xref: MassAvg: "188.23" +xref: MassMono: "188.094963" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue +is_a: MOD:01473 ! hydrogenated residue + +[Term] +id: MOD:00963 +name: Oxidation of Trp to kynurenine +def: "Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462." [DeltaMass:357] +comment: From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00964 +name: lysine epsilon amino to imine + 12 amu +def: "modification from DeltaMass" [DeltaMass:34] +comment: From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt. +synonym: "N6-(methylidene)-lysine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "12.01" +xref: DiffFormula: "C 1 H 0 N 0 O 0" +xref: DiffMono: "12.000000" +xref: Formula: "C 7 H 12 N 2 O 1" +xref: MassAvg: "140.19" +xref: MassMono: "140.094963" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00965 +name: 4-thiazolidinecarboxylic acid +def: "A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid." [DeltaMass:342] +comment: From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501. +synonym: "thioproline" EXACT DeltaMass-label [] +xref: DiffAvg: "12.01" +xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0" +xref: DiffMono: "12.000000" +xref: Formula: "C 4 H 6 N 1 O 1 S 1" +xref: MassAvg: "116.16" +xref: MassMono: "116.017010" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:00966 +name: 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid +def: "A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid." [DeltaMass:339] +comment: From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red. +xref: DiffAvg: "12.01" +xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0" +xref: DiffMono: "12.000000" +xref: Formula: "C 12 H 10 N 2 O 1" +xref: MassAvg: "198.22" +xref: MassMono: "198.079313" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:00967 +name: syndesine +def: "A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine." [DeltaMass:35, PubMed:75151974] +comment: Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG]. +synonym: "hydroxylysinohydroxynorleucine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "16.96" +xref: DiffFormula: "C 0 H -3 N -2 O 3" +xref: DiffMono: "16.955121" +xref: Formula: "C 12 H 21 N 2 O 5" +xref: MassAvg: "273.31" +xref: MassMono: "273.145047" +xref: Origin: "K, K" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00968 +name: CM-Cys vs PAM-Cys +def: "modification from DeltaMass" [DeltaMass:347] +comment: From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00969 +name: CAM-Cys vs PAM-Cys +def: "modification from DeltaMass" [DeltaMass:346] +comment: From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00970 +name: delta-hydroxy-allysine (Lys) +def: "modification from DeltaMass" [DeltaMass:37] +comment: From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00971 +name: Oxohistidine (from histidine) +def: "modification from DeltaMass" [DeltaMass:38] +comment: From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "H" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00972 +name: monobrominated L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine." [UniMod:340#F] +comment: From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa +synonym: "Br1Phe" EXACT PSI-MOD-label [] +synonym: "bromination" RELATED UniMod-description [] +synonym: "Bromo" RELATED PSI-MS-label [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 9 H 8 N 1 O 1" +xref: MassAvg: "226.07" +xref: MassMono: "224.978926" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01066 ! halogenated phenylalanine +is_a: MOD:01912 ! monobrominated residue + +[Term] +id: MOD:00973 +name: Oxidation of proline (to glutamic acid) +def: "modification from DeltaMass" [DeltaMass:355] +comment: From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished) +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00974 +name: (35)Cl labeled 3'-chlorotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 34 +xref: DiffAvg: "33.96" +xref: DiffFormula: "(35)Cl 1 H -1" +xref: DiffMono: "33.961028" +xref: Formula: "C 9 (35)Cl 1 H 8 N 1 O 2" +xref: MassAvg: "197.02" +xref: MassMono: "197.024356" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01046 ! 3'-chloro-L-tyrosine + +[Term] +id: MOD:00975 +name: (37)Cl labeled 3'-chlorotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 36 +xref: DiffAvg: "35.96" +xref: DiffFormula: "(37)Cl 1 H -1" +xref: DiffMono: "35.958078" +xref: Formula: "C 9 (37)Cl 1 H 8 N 1 O 2" +xref: MassAvg: "199.02" +xref: MassMono: "199.021406" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01046 ! 3'-chloro-L-tyrosine + +[Term] +id: MOD:00976 +name: potassium salt +def: "modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 38 +xref: DiffAvg: "38.09" +xref: DiffFormula: "H -1 K 1" +xref: DiffMono: "37.955882" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00977 +name: disodium salt +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 44 +subset: PSI-MOD-slim +xref: DiffAvg: "43.96" +xref: DiffFormula: "H -2 Na 2" +xref: DiffMono: "43.963888" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00747 ! sodium containing modified residue + +[Term] +id: MOD:00978 +name: piperidine adduct to C-terminal Cys +def: "modification from DeltaMass" [DeltaMass:345] +comment: From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00979 +name: t-butyl ester (OtBu) and t-butyl (tBu) +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 56 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00980 +name: Carboxamidomethyl (on Cysteine) +def: "modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060." [DeltaMass:337] +comment: From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00981 +name: sodium and potassium salt +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 60 +subset: PSI-MOD-slim +xref: DiffAvg: "60.07" +xref: DiffFormula: "H -2 K 1 Na 1" +xref: DiffMono: "59.937826" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00747 ! sodium containing modified residue +is_a: MOD:00849 ! potassium containing modified residue + +[Term] +id: MOD:00982 +name: L-selenocysteine (Ser) +def: "A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process)." [DeltaMass:0] +comment: [From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG]. +synonym: "Sec(Ser)" EXACT PSI-MOD-label [] +synonym: "Selenocysteine (from Serine)" EXACT DeltaMass-label [] +xref: DiffAvg: "62.97" +xref: DiffFormula: "C 0 H 0 N 0 O -1 Se 1" +xref: DiffMono: "63.921607" +xref: Formula: "C 3 H 5 N 1 O 1 Se 1" +xref: MassAvg: "150.05" +xref: MassMono: "150.953635" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00031 ! L-selenocysteine residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:00983 +name: Asp transamidation with piperidine +def: "modification from DeltaMass" [DeltaMass:67] +comment: From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00984 +name: (35)Cl labeled 3',5'-dichlorotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 68 +xref: DiffAvg: "67.92" +xref: DiffFormula: "(35)Cl 2 H -2" +xref: DiffMono: "67.922055" +xref: Formula: "C 9 (35)Cl 2 H 7 N 1 O 2" +xref: MassAvg: "230.99" +xref: MassMono: "230.985384" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01045 ! 3',5'-dichloro-L-tyrosine + +[Term] +id: MOD:00985 +name: halogenated tyrosine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "HalTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:00986 +name: (35)Cl and (37)Cl labeled 3',5'-dichlorotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 70. +xref: DiffAvg: "69.92" +xref: DiffFormula: "(35)Cl 1 (37)Cl 1 H -2" +xref: DiffMono: "69.919105" +xref: Formula: "C 9 (35)Cl 1 (37)Cl 1 H 7 N 1 O 2" +xref: MassAvg: "232.98" +xref: MassMono: "232.982434" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01045 ! 3',5'-dichloro-L-tyrosine + +[Term] +id: MOD:00987 +name: chlorinated tyrosine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom." [PubMed:18688235] +synonym: "ClTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00753 ! chlorinated residue +is_a: MOD:00985 ! halogenated tyrosine + +[Term] +id: MOD:00988 +name: brominated tyrosine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom." [PubMed:18688235] +synonym: "BrTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00754 ! brominated residue +is_a: MOD:00985 ! halogenated tyrosine + +[Term] +id: MOD:00989 +name: acetamidomethyl (Acm) +def: "OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079." [DeltaMass:0] +comment: From DeltaMass with no citation or formula. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:00990 +name: (37)Cl labeled 3',5'-dichlorotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 72 +xref: DiffAvg: "71.92" +xref: DiffFormula: "(37)Cl 2 H -2" +xref: DiffMono: "71.916155" +xref: Formula: "C 9 (37)Cl 2 H 7 N 1 O 2" +xref: MassAvg: "234.98" +xref: MassMono: "234.979484" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01045 ! 3',5'-dichloro-L-tyrosine + +[Term] +id: MOD:00991 +name: S-(sn-1-glyceryl)-L-cysteine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 74 with no citation. +xref: DiffAvg: "74.08" +xref: DiffFormula: "C 3 H 6 O 2" +xref: DiffMono: "74.036779" +xref: Formula: "C 6 H 11 N 1 O 3 S 1" +xref: MassAvg: "177.22" +xref: MassMono: "177.045964" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:00992 +name: glutamate 5-glycerol ester +def: "modification from DeltaMass" [DeltaMass:78, PubMed:18767873] +comment: From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG]. +xref: DiffAvg: "74.08" +xref: DiffFormula: "C 3 H 6 O 2" +xref: DiffMono: "74.036779" +xref: Formula: "C 8 H 13 N 1 O 5" +xref: MassAvg: "203.19" +xref: MassMono: "203.079373" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:00993 +name: phenyl ester +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 76, on acidic amino acids +synonym: "OPh" EXACT DeltaMass-label [] +xref: DiffAvg: "76.10" +xref: DiffFormula: "C 6 H 4" +xref: DiffMono: "76.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00994 +name: (79)Br labeled 3'-bromotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 78 +xref: DiffAvg: "77.91" +xref: DiffFormula: "(79)Br 1 H -1" +xref: DiffMono: "77.910512" +xref: Formula: "(79)Br 1 C 9 H 8 N 1 O 2" +xref: MassAvg: "240.97" +xref: MassMono: "240.973841" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01025 ! 3'-bromo-L-tyrosine + +[Term] +id: MOD:00995 +name: (81)Br labeled 2'-bromophenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 80 +xref: DiffAvg: "79.91" +xref: DiffFormula: "(81)Br 1 H -1" +xref: DiffMono: "79.908466" +xref: Formula: "(81)Br 1 C 9 H 8 N 1 O 1" +xref: MassAvg: "226.98" +xref: MassMono: "226.976879" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00183 ! L-2'-bromophenylalanine + +[Term] +id: MOD:00996 +name: (81)Br labeled 3'-bromotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 80 +xref: DiffAvg: "79.91" +xref: DiffFormula: "(81)Br 1 H -1" +xref: DiffMono: "79.908466" +xref: Formula: "(81)Br 1 C 9 H 8 N 1 O 2" +xref: MassAvg: "242.97" +xref: MassMono: "242.971794" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01025 ! 3'-bromo-L-tyrosine + +[Term] +id: MOD:00997 +name: cyclohexyl ester +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 82 +synonym: "OcHex" EXACT DeltaMass-label [] +xref: DiffAvg: "82.15" +xref: DiffFormula: "C 6 H 10" +xref: DiffMono: "82.078250" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:00998 +name: iodinated tyrosine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "ITyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00755 ! iodinated residue +is_a: MOD:00985 ! halogenated tyrosine + +[Term] +id: MOD:00999 +name: homoseryl lactone +def: "OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404." [DeltaMass:90] +comment: From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01000 +name: monobrominated tyrosine +def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom." [PubMed:18688235] +synonym: "Br1Tyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00988 ! brominated tyrosine + +[Term] +id: MOD:01001 +name: 2-aminoisobutyric acid residue (Aib) +def: "A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid." [DeltaMass:0] +comment: Modification from DeltaMass: Average Mass: 85. +synonym: "2-amino-2-methylpropanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-amino-2-methylpropionic acid" EXACT PSI-MOD-alternate [] +synonym: "2-methylalanine" EXACT PSI-MOD-alternate [] +synonym: "Aib" EXACT PSI-MOD-alternate [] +synonym: "alpha,alpha-dimethylglycine" EXACT PSI-MOD-alternate [] +synonym: "alpha-aminoisobutyric acid" EXACT PSI-MOD-alternate [] +synonym: "alpha-methylalanine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 4 H 7 N 1 O 1" +xref: MassAvg: "85.11" +xref: MassMono: "85.052764" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00850 ! unnatural residue + +[Term] +id: MOD:01002 +name: gamma-aminobutyryl +def: "modification from DeltaMass" [DeltaMass:92] +comment: From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106 +xref: DiffAvg: "85.11" +xref: DiffFormula: "C 4 H 7 N 1 O 1" +xref: DiffMono: "85.052764" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01003 +name: t-butyloxymethyl (Bum) +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 86 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01004 +name: diaminopropionyl +def: "modification from DeltaMass" [DeltaMass:95] +comment: From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094 +xref: DiffAvg: "86.09" +xref: DiffFormula: "C 3 H 6 N 2 O 1" +xref: DiffMono: "86.048013" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01005 +name: t-butylsulfenyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 88 +synonym: "StBu" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01006 +name: dibrominated tyrosine +def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms." [UniMod:534] +synonym: "Br2Tyr" EXACT PSI-MOD-label [] +synonym: "Dibromo" RELATED PSI-MS-label [] +synonym: "Dibromo" RELATED UniMod-description [] +xref: DiffAvg: "157.79" +xref: DiffFormula: "Br 2 C 0 H -2 N 0 O 0" +xref: DiffMono: "155.821024" +xref: Formula: "Br 2 C 9 H 7 N 1 O 2" +xref: MassAvg: "320.97" +xref: MassMono: "318.884353" +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00988 ! brominated tyrosine + +[Term] +id: MOD:01007 +name: anisyl modified residue +def: "A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position." [DeltaMass:0] +comment: From DeltaMass with no citation or formula: Average Mass: 90. +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01008 +name: benzyl (Bzl) and benzyl ester (OBzl) modified residue +def: "A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom." [DeltaMass:0] +comment: From DeltaMass with no citation or formula: Average Mass: 90 +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01009 +name: dehydrogenated proline +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass with no citation. +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 5 H 5 N 1 O 1" +xref: MassAvg: "95.10" +xref: MassMono: "95.037114" +xref: Origin: "P" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01010 +name: trifluoroacetylated residue +def: "A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom." [DeltaMass:0] +synonym: "TFA" EXACT DeltaMass-label [] +xref: DiffAvg: "96.01" +xref: DiffFormula: "C 2 F 3 H -1 O 1" +xref: DiffMono: "95.982299" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00498 ! fluorinated residue +is_a: MOD:00649 ! acylated residue +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01011 +name: N-hydroxysuccinimide (ONSu, OSu) +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 97 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01012 +name: oxidation of disulfide crosslink in cystine to two cysteic acids +def: "A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues." [DeltaMass:335] +comment: Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. +xref: DiffAvg: "98.01" +xref: DiffFormula: "C 0 H 2 N 0 O 6 S 0" +xref: DiffMono: "97.985138" +xref: Formula: "C 6 H 10 N 2 O 8 S 2" +xref: MassAvg: "302.27" +xref: MassMono: "301.987857" +xref: Origin: "MOD:00034" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00460 ! L-cysteic acid (L-cysteine sulfonic acid) +relationship: derives_from MOD:00034 ! L-cystine (cross-link) + +[Term] +id: MOD:01013 +name: tetramethylguanidinium termination by-product on amine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 98 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01014 +name: phosphate/sulphate adduct of proteins +def: "modification from DeltaMass" [DeltaMass:358] +comment: From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01015 +name: isovaline residue (Iva) +def: "A protein modification that inserts or replaces a residue with an isovaline." [DeltaMass:110] +synonym: "2-amino-2-methylbutanoic acid" EXACT PSI-MOD-alternate [] +synonym: "Isovalyl (-I-,-Iva-)" EXACT DeltaMass-label [] +synonym: "Iva" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 9 N 1 O 1" +xref: MassAvg: "99.13" +xref: MassMono: "99.068414" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00850 ! unnatural residue + +[Term] +id: MOD:01016 +name: t-butyloxycarbonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 100 +synonym: "tBoc" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01017 +name: homoseryl (-Hse-) +def: "OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403." [DeltaMass:113] +comment: From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01018 +name: 4-methylbenzyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 104 +synonym: "Meb" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01019 +name: hydroxymethylphenyl linker +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 106 +synonym: "HMP" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01020 +name: thioanisyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 106 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01021 +name: thiocresyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 106 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01022 +name: 2-piperidinecarboxylic acid +def: "A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid." [DeltaMass:0] +synonym: "Pip" EXACT DeltaMass-label [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 6 H 9 N 1 O 1" +xref: MassAvg: "111.14" +xref: MassMono: "111.068414" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01160 ! deaminated residue + +[Term] +id: MOD:01023 +name: 3',5'-dibromo-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine." [DeltaMass:156] +synonym: "3',5'-Br2Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "157.79" +xref: DiffFormula: "Br 2 C 0 H -2 N 0 O 0" +xref: DiffMono: "155.821024" +xref: Formula: "Br 2 C 9 H 7 N 1 O 2" +xref: MassAvg: "320.97" +xref: MassMono: "318.884353" +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01006 ! dibrominated tyrosine + +[Term] +id: MOD:01024 +name: monohydroxylated proline +def: "A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline." [DeltaMass:0, OMSSA:62, UniMod:35#P] +comment: From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG]. +subset: PSI-MOD-slim +synonym: "Hy1Pro" EXACT PSI-MOD-label [] +synonym: "hydroxylationp" EXACT OMSSA-label [] +synonym: "Hydroxyproline" EXACT DeltaMass-label [] +synonym: "Hyp" EXACT DeltaMass-label [] +synonym: "Oxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00594 ! residues isobaric at 113.047678 Da +is_a: MOD:00678 ! hydroxylated proline + +[Term] +id: MOD:01025 +name: 3'-bromo-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine." [PubMed:18688235] +synonym: "3'-BrTyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 H -1" +xref: DiffMono: "77.910512" +xref: Formula: "Br 1 C 9 H 8 N 1 O 2" +xref: MassAvg: "242.07" +xref: MassMono: "240.973841" +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01000 ! monobrominated tyrosine + +[Term] +id: MOD:01026 +name: norleucine residue (Nle) +def: "A protein modification that inserts or replaces a residue with a norleucine." [DeltaMass:126] +synonym: "Nle" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00850 ! unnatural residue + +[Term] +id: MOD:01027 +name: t-amyloxycarbonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 114 +synonym: "Aoc" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01028 +name: monochlorinated L-tyrosine +def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom." [PubMed:18688235] +synonym: "Cl1Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 9 Cl 1 H 8 N 1 O 2" +xref: MassAvg: "197.62" +xref: MassMono: "197.024356" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00987 ! chlorinated tyrosine +is_a: MOD:01911 ! monochlorinated residue + +[Term] +id: MOD:01029 +name: succinylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon." [DeltaMass:0, UniMod:64] +comment: From DeltaMass with no citation or formula, Average Mass: 117 [JSG]. +subset: PSI-MOD-slim +synonym: "Succinic anhydride labeling reagent light form (N-term & K)" RELATED UniMod-description [] +xref: DiffAvg: "100.07" +xref: DiffFormula: "C 4 H 4 O 3" +xref: DiffMono: "100.016044" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:01030 +name: hydroxybenzotriazole ester +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 117 +synonym: "HOBt" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01031 +name: dimethylbenzyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 118 +synonym: "diMeBzl" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01032 +name: benzyloxymethyl modified residue +def: "A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Bom" EXACT DeltaMass-label [] +xref: DiffAvg: "120.15" +xref: DiffFormula: "C 8 H 8 O 1" +xref: DiffMono: "120.057515" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01033 +name: p-methoxybenzyl modified residue +def: "A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Mbzl" EXACT DeltaMass-label [] +synonym: "Mob" EXACT DeltaMass-label [] +xref: DiffAvg: "120.15" +xref: DiffFormula: "C 8 H 8 O 1" +xref: DiffMono: "120.057515" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01034 +name: 4-nitrophenyl modified residue +def: "A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom." [DeltaMass:0] +synonym: "ONp" EXACT DeltaMass-label [] +synonym: "p-nitrophenyl" EXACT DeltaMass-label [] +xref: DiffAvg: "121.10" +xref: DiffFormula: "C 6 H 3 N 1 O 2" +xref: DiffMono: "121.016378" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01035 +name: chlorobenzyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 125 +synonym: "ClBzl" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01036 +name: O-methyl aspartyl +def: "OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181." [PubMed:18688235] +comment: From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "D" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01037 +name: dichlorinated tyrosine +def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms." [PubMed:18688235] +synonym: "Cl2Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "68.88" +xref: DiffFormula: "C 0 Cl 2 H -2 N 0 O 0" +xref: DiffMono: "67.922055" +xref: Formula: "C 9 Cl 2 H 7 N 1 O 2" +xref: MassAvg: "232.06" +xref: MassMono: "230.985384" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00987 ! chlorinated tyrosine + +[Term] +id: MOD:01038 +name: norleucine (Nle) +def: "OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 131. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01039 +name: hydroxy aspartyl +def: "OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036." [PubMed:18688235] +comment: From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 4 H 5 N 1 O 4" +xref: MassAvg: "131.09" +xref: MassMono: "131.021858" +xref: Origin: "D" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01040 +name: penicillamine residue +def: "A protein modification that inserts or replaces a residue with a penicillamine." [DeltaMass:154] +comment: From DeltaMass: Name misspelled 'bb-dimethyl cystenyl'. No citation provided. +synonym: "2-amino-3-mercapto-3-methylbutanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-amino-3-methyl-3-sulfanylbutanoic acid" EXACT PSI-MOD-alternate [] +synonym: "3,3-dimethylcysteine" EXACT PSI-MOD-alternate [] +synonym: "3-mercapto-L-valine" EXACT PSI-MOD-alternate [] +synonym: "beta,beta-dimethylcysteine" EXACT DeltaMass-label [] +synonym: "Pen" EXACT DeltaMass-label [] +synonym: "Pen" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "131.19" +xref: MassMono: "131.040485" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00850 ! unnatural residue + +[Term] +id: MOD:01041 +name: benzyloxycarbonyl modified residue +def: "A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Z" EXACT DeltaMass-label [] +xref: DiffAvg: "134.13" +xref: DiffFormula: "C 8 H 6 O 2" +xref: DiffMono: "134.036779" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01042 +name: adamantyl modified residue +def: "A protein modification that effectively substitutes a adamantyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Ada" EXACT DeltaMass-label [] +xref: DiffAvg: "134.22" +xref: DiffFormula: "C 10 H 14" +xref: DiffMono: "134.109550" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01043 +name: p-nitrobenzyl ester modified residue +def: "A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group." [DeltaMass:0] +synonym: "ONb" EXACT DeltaMass-label [] +xref: DiffAvg: "135.12" +xref: DiffFormula: "C 7 H 5 N 1 O 2" +xref: DiffMono: "135.032028" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01044 +name: N-methyl glutamyl +def: "OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080." [DeltaMass:166] +comment: From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl) +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Q" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01045 +name: 3',5'-dichloro-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine." [PubMed:18688235] +synonym: "3',5'-Cl2Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "68.88" +xref: DiffFormula: "C 0 Cl 2 H -2 N 0 O 0" +xref: DiffMono: "67.922055" +xref: Formula: "C 9 Cl 2 H 7 N 1 O 2" +xref: MassAvg: "232.06" +xref: MassMono: "230.985384" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01037 ! dichlorinated tyrosine + +[Term] +id: MOD:01046 +name: 3'-chloro-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine." [PubMed:18688235] +synonym: "3'-ClTyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 9 Cl 1 H 8 N 1 O 2" +xref: MassAvg: "197.62" +xref: MassMono: "197.024356" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01028 ! monochlorinated L-tyrosine + +[Term] +id: MOD:01047 +name: monohydroxylated lysine +def: "A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine." [DeltaMass:168, OMSSA:60, UniMod:35#K] +comment: From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174. +subset: PSI-MOD-slim +synonym: "Hy1Lys" EXACT PSI-MOD-label [] +synonym: "Hydroxy Lysyl (-Hyl-)" EXACT DeltaMass-label [] +synonym: "hydroxylationk" EXACT OMSSA-label [] +synonym: "Oxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 2 O 2" +xref: MassAvg: "144.17" +xref: MassMono: "144.089878" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00681 ! hydroxylated lysine + +[Term] +id: MOD:01048 +name: 2-pyrrolidone-5-carboxylic acid +def: "A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid." [PubMed:18688235] +comment: From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52. +subset: PSI-MOD-slim +synonym: "PyrGlu" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 6 N 1 O 2" +xref: MassAvg: "112.11" +xref: MassMono: "112.039853" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "N-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01049 +name: halogenated histidine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom." [PubMed:18688235] +synonym: "HalHis" EXACT PSI-MOD-label [] +xref: Origin: "H" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01050 +name: pyridyl alanyl +def: "modification from DeltaMass" [DeltaMass:180] +comment: From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "A" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01051 +name: 2-nitrobenzoyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 149 +synonym: "NBz" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01052 +name: dimethoxybenzyl Trp +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 150 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01053 +name: 2-nitrophenylsulphenyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 153 +synonym: "Nps" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01054 +name: 4-toluenesulfonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 154 +synonym: "4-toluenesulphonyl" EXACT DeltaMass-label [] +synonym: "Tos" EXACT DeltaMass-label [] +synonym: "Tosyl" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01055 +name: 3-nitro-2-pyridinesulfenyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 154 +synonym: "Npys" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01056 +name: (79)Br labeled 3',5'-dibromotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 156 +xref: DiffAvg: "155.82" +xref: DiffFormula: "(79)Br 2 C 0 H -2 N 0 O 0" +xref: DiffMono: "155.821024" +xref: Formula: "(79)Br 2 C 9 H 7 N 1 O 2" +xref: MassAvg: "318.88" +xref: MassMono: "318.884353" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01023 ! 3',5'-dibromo-L-tyrosine + +[Term] +id: MOD:01057 +name: (79)Br and (81)Br labeled 3',5'-dibromotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 158 +xref: DiffAvg: "157.82" +xref: DiffFormula: "(79)Br 1 (81)Br 1 C 0 H -2 N 0 O 0" +xref: DiffMono: "157.818978" +xref: Formula: "(79)Br 1 (81)Br 1 C 9 H 7 N 1 O 2" +xref: MassAvg: "320.88" +xref: MassMono: "320.882306" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01023 ! 3',5'-dibromo-L-tyrosine + +[Term] +id: MOD:01058 +name: dichlorobenzyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 159 +synonym: "Dcb" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01059 +name: (81)Br labeled 3',5'-dibromotyrosine +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 160 +xref: DiffAvg: "159.82" +xref: DiffFormula: "(81)Br 2 C 0 H -2 N 0 O 0" +xref: DiffMono: "159.816931" +xref: Formula: "(81)Br 2 C 9 H 7 N 1 O 2" +xref: MassAvg: "322.88" +xref: MassMono: "322.880260" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01023 ! 3',5'-dibromo-L-tyrosine + +[Term] +id: MOD:01060 +name: S-carboxamidomethyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine." [DeltaMass:196, DeltaMass:337, OMSSA:3, PubMed:10504701, PubMed:11510821, PubMed:12422359, PubMed:18306178, UniMod:4#C] +comment: From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG]. +subset: PSI-MOD-slim +synonym: "amidocarboxymethylcysteine" EXACT DeltaMass-label [] +synonym: "CamC" EXACT PSI-MOD-alternate [] +synonym: "CamCys" EXACT DeltaMass-label [] +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "carbamidomethylc" EXACT OMSSA-label [] +synonym: "carbamoylmethylcysteine" EXACT DeltaMass-label [] +synonym: "Carboxamidomethyl (on Cysteine)" EXACT DeltaMass-label [] +synonym: "Carboxyamidomethyl Cystenyl" EXACT DeltaMass-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +synonym: "S-carbamoylmethyl-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1 S 0" +xref: DiffMono: "57.021464" +xref: Formula: "C 5 H 8 N 2 O 2 S 1" +xref: MassAvg: "160.19" +xref: MassMono: "160.030649" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01061 +name: S-carboxymethyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine." [DeltaMass:0, DeltaMass:197, OMSSA:2, UniMod:6#C] +comment: From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG]. +subset: PSI-MOD-slim +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Carboxymethyl cysteine" EXACT DeltaMass-label [] +synonym: "Carboxymethyl Cystenyl" EXACT DeltaMass-label [] +synonym: "carboxymethylc" EXACT OMSSA-label [] +synonym: "CmC" EXACT PSI-MOD-alternate [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 N 0 O 2 S 0" +xref: DiffMono: "58.005479" +xref: Formula: "C 5 H 7 N 1 O 3 S 1" +xref: MassAvg: "161.18" +xref: MassMono: "161.014664" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00399 ! iodoacetic acid derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01062 +name: carboxymethyl cysteinyl +def: "OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061" [DeltaMass:197] +comment: From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179 +synonym: "Carboxymethyl Cystenyl" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 7 N 3 O 1 S 1" +xref: MassAvg: "157.19" +xref: MassMono: "157.030983" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01063 +name: monomethylated phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine." [DeltaMass:198] +comment: From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG]. +subset: PSI-MOD-slim +synonym: "NMePhe" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 10 H 11 N 1 O 1" +xref: MassAvg: "161.20" +xref: MassMono: "161.084064" +xref: Origin: "F" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00717 ! methylated phenylalanine + +[Term] +id: MOD:01064 +name: inositol +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 162 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01065 +name: hexose glycated N-terminal +def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine (or aminoketose) residue adduct." [DeltaMass:0, UniMod:41#N-term] +comment: From DeltaMass: Average Mass: 162 +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "N-term" +is_a: MOD:00767 ! glycated residue + +[Term] +id: MOD:01066 +name: halogenated phenylalanine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom." [PubMed:18688235] +synonym: "HalPhe" EXACT PSI-MOD-label [] +xref: Origin: "F" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:01067 +name: linker attached to peptide in Fmoc peptide synthesis +def: "modification from DeltaMass" [DeltaMass:341] +comment: From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01068 +name: halogenated tryptophan +def: "A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom." [PubMed:18688235] +synonym: "HalTrp" EXACT PSI-MOD-label [] +xref: Origin: "W" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01069 +name: 2,4-dinitrophenyl modified residue +def: "A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Dnp" EXACT DeltaMass-label [] +xref: DiffAvg: "166.09" +xref: DiffFormula: "C 6 H 2 N 2 O 4" +xref: DiffMono: "166.001457" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01070 +name: pentafluorophenyl modified residue +def: "A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom." [DeltaMass:0] +comment: From DeltaMass: name mispelled "pentaflourophenyl" +synonym: "Pfp" EXACT DeltaMass-label [] +xref: DiffAvg: "166.05" +xref: DiffFormula: "C 6 F 5 H -1" +xref: DiffMono: "165.984191" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01071 +name: diphenylmethyl modified residue +def: "A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Dpm" EXACT DeltaMass-label [] +xref: DiffAvg: "166.22" +xref: DiffFormula: "C 13 H 10" +xref: DiffMono: "166.078250" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01072 +name: monopotassium salt +def: "A protein modification that effectively substitutes one potassium atom for one hydrogen atom." [DeltaMass:0] +subset: PSI-MOD-slim +synonym: "K1Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "38.09" +xref: DiffFormula: "H -1 K 1" +xref: DiffMono: "37.955882" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00849 ! potassium containing modified residue + +[Term] +id: MOD:01073 +name: 2-chlorobenzyloxycarbonyl modified residue +def: "A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Clz" EXACT DeltaMass-label [] +xref: DiffAvg: "169.58" +xref: DiffFormula: "C 8 Cl 1 H 6 O 2" +xref: DiffMono: "169.005632" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01074 +name: napthylacetyl modified residue +def: "A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom." [DeltaMass:0] +xref: DiffAvg: "169.20" +xref: DiffFormula: "C 12 H 9 O 1" +xref: DiffMono: "169.065340" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01075 +name: mercury containing modified residue +def: "A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion." [PubMed:18688235] +synonym: "HgRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:01076 +name: N-methyl arginyl +def: "modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414." [DeltaMass:215] +comment: From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 7 H 14 N 4 O 1" +xref: MassAvg: "170.22" +xref: MassMono: "170.116761" +xref: Origin: "R" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01077 +name: ethanedithiol/TFA cyclic adduct +def: "modification from DeltaMass" [DeltaMass:216] +comment: From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997) +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01078 +name: S-(2-aminoethyl)-3-methylcysteine (Thr) +def: "A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine." [PubMed:12923550, UniMod:472#T] +comment: From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. +synonym: "2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid" EXACT PSI-MOD-alternate [] +synonym: "AEC-MAEC" RELATED UniMod-interim [] +synonym: "beta-methylaminoethylcysteine" RELATED UniMod-description [] +synonym: "S-aminoethyl-3-methylcysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "59.13" +xref: DiffFormula: "C 2 H 5 N 1 O -1 S 1" +xref: DiffMono: "59.019356" +xref: Formula: "C 6 H 12 N 2 O 1 S 1" +xref: MassAvg: "160.24" +xref: MassMono: "160.067034" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01079 +name: S-(acetylamino)methyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine." [DeltaMass:218, PubMed:8572278] +comment: From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG]. +synonym: "Acetamidomethyl Cystenyl" EXACT DeltaMass-label [] +synonym: "Acm-Cys" EXACT PSI-MOD-alternate [] +synonym: "N-(hydroxymethyl)acetamide derivatized L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-(acetamido)methyl-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "71.08" +xref: DiffFormula: "C 3 H 5 N 1 O 1 S 0" +xref: DiffMono: "71.037114" +xref: Formula: "C 6 H 10 N 2 O 2 S 1" +xref: MassAvg: "174.22" +xref: MassMono: "174.046299" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01080 +name: acrylamidyl cysteinyl +def: "modification from DeltaMass" [DeltaMass:219] +comment: From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221 +synonym: "Acrylamidyl Cystenyl" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 10 N 2 O 2 S 1" +xref: MassAvg: "174.22" +xref: MassMono: "174.046299" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01081 +name: delta-glycosyloxy- (of lysine) or beta-glycosyloxy- (of phenylalanine or tyrosine) +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 177. CAUTION - mass does not match formula. +xref: DiffAvg: "178.14" +xref: DiffFormula: "C 6 H 10 O 6" +xref: DiffMono: "178.047738" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01082 +name: 4-glycosyloxy- (hexosyl, C6) (of proline) +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose. +xref: DiffAvg: "178.14" +xref: DiffFormula: "C 6 H 10 O 6" +xref: DiffMono: "178.047738" +xref: Formula: "C 11 H 17 N 1 O 6" +xref: MassAvg: "259.26" +xref: MassMono: "259.105587" +xref: Origin: "P" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01083 +name: O-benzyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine." [DeltaMass:0] +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "C 10 H 11 N 1 O 2" +xref: MassAvg: "177.20" +xref: MassMono: "177.078979" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue + +[Term] +id: MOD:01084 +name: iodoacetic acid derivatized amino-terminal residue +def: "A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group." [UniMod:6#N-term] +subset: PSI-MOD-slim +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Carboxymethyl (on Cysteine)" EXACT DeltaMass-label [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00399 ! iodoacetic acid derivatized residue + +[Term] +id: MOD:01085 +name: alpha-N-gluconoylation (His Tagged proteins) +def: "modification from DeltaMass" [DeltaMass:226] +comment: From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01086 +name: p-nitrobenzyloxycarbonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 179 +synonym: "4Nz" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01087 +name: 2,4,5-trichlorophenyl modified residue +def: "A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom." [DeltaMass:0] +xref: DiffAvg: "179.42" +xref: DiffFormula: "C 6 Cl 3 H 1" +xref: DiffMono: "177.914383" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01088 +name: 2,4,6-trimethyloxybenzyl modified residue +def: "A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom." [DeltaMass:0] +synonym: "Tmob" EXACT DeltaMass-label [] +xref: DiffAvg: "180.20" +xref: DiffFormula: "C 10 H 12 O 3" +xref: DiffMono: "180.078644" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01089 +name: xanthyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 180 +synonym: "Xan" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01090 +name: iodoacetamide derivatized amino-terminal residue +def: "A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group." [PubMed:11327326, PubMed:11510821, PubMed:12422359, UniMod:4#N-term] +subset: PSI-MOD-slim +synonym: "(carbamoylmethyl)amino" EXACT PSI-MOD-alternate [] +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00397 ! iodoacetamide derivatized residue + +[Term] +id: MOD:01091 +name: monochlorinated L-phenylalanine +def: "A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom." [DeltaMass:233] +comment: From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623 +synonym: "Cl1Phe" EXACT PSI-MOD-label [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 9 Cl 1 H 8 N 1 O 1" +xref: MassAvg: "181.62" +xref: MassMono: "181.029442" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01066 ! halogenated phenylalanine +is_a: MOD:01911 ! monochlorinated residue + +[Term] +id: MOD:01092 +name: mesitylene-2-sulfonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 182 +synonym: "Mts" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01093 +name: isopropyl lysyl +def: "modification from DeltaMass" [DeltaMass:236] +comment: From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 9 H 16 N 2 O 2" +xref: MassAvg: "184.24" +xref: MassMono: "184.121178" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01094 +name: N6-carboxymethyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine." [DeltaMass:237, UniMod:6#K] +comment: From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG]. +subset: PSI-MOD-slim +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Carboxymethyl Lysyl" EXACT DeltaMass-label [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "C 8 H 14 N 2 O 3" +xref: MassAvg: "186.21" +xref: MassMono: "186.100442" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00399 ! iodoacetic acid derivatized residue + +[Term] +id: MOD:01095 +name: Matrix alpha cyano MH+ +def: "Modification from DeltaMass. OBSOLETE because not an amino acid modification." [DeltaMass:240] +comment: From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 10 H 8 N 1 O 3" +xref: MassAvg: "190.18" +xref: MassMono: "190.050418" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01096 +name: O-benzyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine." [DeltaMass:0] +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "C 11 H 13 N 1 O 2" +xref: MassAvg: "191.23" +xref: MassMono: "191.094629" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue + +[Term] +id: MOD:01097 +name: S-benzyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine." [DeltaMass:242] +comment: From DeltaMass: misspelled "Benzyl Cystenyl". +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "C 10 H 11 N 1 O 1 S 1" +xref: MassAvg: "193.26" +xref: MassMono: "193.056135" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue + +[Term] +id: MOD:01098 +name: naphthylalanine residue +def: "A protein modification that inserts or replaces a residue with a naphthylalanine." [DeltaMass:243] +comment: From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG]. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 13 H 11 N 1 O 1" +xref: MassAvg: "197.24" +xref: MassMono: "197.084064" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00850 ! unnatural residue + +[Term] +id: MOD:01099 +name: succinyl beta-aspartyl anhydride +def: "A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride." [DeltaMass:244] +comment: From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG]. +synonym: "succinyl aspartamyl" EXACT DeltaMass-label [] +xref: DiffAvg: "82.06" +xref: DiffFormula: "C 4 H 2 N 0 O 2" +xref: DiffMono: "82.005479" +xref: Formula: "C 8 H 8 N 1 O 5" +xref: MassAvg: "198.15" +xref: MassMono: "198.040247" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01029 ! succinylated residue + +[Term] +id: MOD:01100 +name: HMP (hydroxymethylphenyl)/TFA adduct +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 201 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01101 +name: S-Farnesyl- +def: "OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111." [DeltaMass:0] +comment: Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01102 +name: myristoylation-4H (two double bonds) +def: "OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504." [DeltaMass:348] +comment: From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds) +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01103 +name: myristoleylation (one double bond) +def: "OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503." [DeltaMass:0] +comment: From DeltaMass with no citation or formula: Average Mass: 208. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01104 +name: 4-methoxy-2,3,6-trimethylbenzenesulfonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 212 with no citation. +synonym: "Mtr" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01105 +name: 2-bromobenzyloxycarbonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 213 with no citation. +synonym: "BrZ" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01106 +name: N-formyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan." [DeltaMass:0] +comment: From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG] +synonym: "formyl tryptophanyl" EXACT DeltaMass-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 12 H 10 N 2 O 2" +xref: MassAvg: "214.22" +xref: MassMono: "214.074228" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01107 +name: O5-benzyl-L-glutamate +def: "A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate." [DeltaMass:258] +comment: From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "C 12 H 13 N 1 O 3" +xref: MassAvg: "219.24" +xref: MassMono: "219.089543" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue + +[Term] +id: MOD:01108 +name: 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu) +def: "A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct." [DeltaMass:259] +comment: From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. +synonym: "anisole adducted glutamyl" EXACT DeltaMass-label [] +xref: DiffAvg: "90.13" +xref: DiffFormula: "C 7 H 6" +xref: DiffMono: "90.046950" +xref: Formula: "C 12 H 13 N 1 O 3" +xref: MassAvg: "219.24" +xref: MassMono: "219.089543" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01007 ! anisyl modified residue + +[Term] +id: MOD:01109 +name: 9-fluorenylmethyloxycarbonyl (Fmoc) +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 222 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01110 +name: isoprenylated cysteine +def: "A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20)." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "IpCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00703 ! isoprenylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01111 +name: dimethoxybenzhydryl modified residue +def: "A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG]. +synonym: "4,4'-dimethoxybenzhydryl" EXACT PSI-MOD-alternate [] +synonym: "bis(4-methoxyphenyl)methyl" EXACT PSI-MOD-alternate [] +synonym: "Mbh" EXACT DeltaMass-label [] +xref: DiffAvg: "226.27" +xref: DiffFormula: "C 15 H 14 O 2" +xref: DiffMono: "226.099380" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01112 +name: nicotinoyl lysine +def: "modification from DeltaMass" [DeltaMass:266] +comment: From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271 +synonym: "nicotinyl lysyl" EXACT DeltaMass-label [] +xref: DiffAvg: "105.10" +xref: DiffFormula: "C 6 H 3 N 1 O 1" +xref: DiffMono: "105.021464" +xref: Formula: "C 12 H 15 N 3 O 2" +xref: MassAvg: "233.27" +xref: MassMono: "233.116427" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01113 +name: 2-(p-biphenyl)isopropyl-oxycarbonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 238 with no citation. +synonym: "Bpoc" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01114 +name: triphenylmethyl +def: "modification from DeltaMass" [DeltaMass:270] +comment: From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N +synonym: "Trityl" EXACT DeltaMass-label [] +synonym: "Trt" EXACT DeltaMass-label [] +xref: DiffAvg: "242.32" +xref: DiffFormula: "C 19 H 14" +xref: DiffMono: "242.109550" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01115 +name: isoprenylated tryptophan +def: "A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20)." [PubMed:18688235] +synonym: "IpTrp" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "W" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00703 ! isoprenylated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01116 +name: S-farnesyl-L-cysteine methyl ester +def: "A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester." [PubMed:15609361, RESID:AA0102#var, RESID:AA0105#var] +subset: PSI-MOD-slim +synonym: "SFarnOMeCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "218.38" +xref: DiffFormula: "C 16 H 26 N 0 O 0 S 0" +xref: DiffMono: "218.203451" +xref: Formula: "C 19 H 32 N 1 O 2 S 1" +xref: MassAvg: "338.53" +xref: MassMono: "338.215375" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00905 ! modified L-cysteine residue +relationship: has_functional_parent MOD:00111 ! S-farnesyl-L-cysteine +relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester + +[Term] +id: MOD:01117 +name: pentamethyldihydrobenzofuransulfonyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 252 with no citation. +synonym: "Pbf" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01118 +name: alpha-N-6-phosphogluconoylation (His Tagged proteins) +def: "modification from DeltaMass" [DeltaMass:275] +comment: From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01119 +name: S-geranylgeranyl-L-cysteine methyl ester +def: "A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester." [PubMed:1483450, PubMed:15609361, RESID:AA0104#var, RESID:AA0105#var] +subset: PSI-MOD-slim +synonym: "SGergerOMeCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "286.50" +xref: DiffFormula: "C 21 H 34 N 0 O 0 S 0" +xref: DiffMono: "286.266051" +xref: Formula: "C 24 H 40 N 1 O 2 S 1" +xref: MassAvg: "406.65" +xref: MassMono: "406.277976" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00905 ! modified L-cysteine residue +relationship: has_functional_parent MOD:00113 ! S-geranylgeranyl-L-cysteine +relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester + +[Term] +id: MOD:01120 +name: 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue +def: "A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG]. +synonym: "2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl" EXACT PSI-MOD-alternate [] +synonym: "2,2,5,7,8-pentamethyl-6-chromansulfonyl" EXACT PSI-MOD-alternate [] +synonym: "2,2,5,7,8-pentamethyl-chromane-6-sulfonyl" EXACT PSI-MOD-alternate [] +synonym: "2,2,5,7,8-pentamethylchroman-6-sulfonyl" EXACT PSI-MOD-alternate [] +synonym: "2,2,5,7,8-pentamethylchroman-6-sulphonyl" EXACT PSI-MOD-alternate [] +synonym: "3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl" EXACT PSI-MOD-alternate [] +synonym: "Pmc" EXACT DeltaMass-label [] +synonym: "PmcRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "266.36" +xref: DiffFormula: "C 14 H 18 O 3 S 1" +xref: DiffMono: "266.097665" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue + +[Term] +id: MOD:01121 +name: monomethoxytrityl +def: "modification from DeltaMass" [DeltaMass:280] +comment: From DeltaMass: Average Mass: 272 Average Mass Change: 272 +synonym: "Mmt" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01122 +name: 5'phos dCytidinyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 289 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01123 +name: monoiodated tyrosine +def: "OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 289 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01124 +name: aldohexosyl lysyl +def: "modification from DeltaMass" [DeltaMass:285] +comment: From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317 +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 N 0 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 12 H 22 N 2 O 6" +xref: MassAvg: "290.32" +xref: MassMono: "290.147786" +xref: Origin: "K" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01125 +name: 5'phos dThymidinyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 304 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01126 +name: 5'phos Cytidinyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 305 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01127 +name: 5'phos Uridinyl +def: "OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166." [DeltaMass:292] +comment: From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01128 +name: N-glycolneuraminic acid +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 307 with no citation. +synonym: "NeuGc" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01129 +name: 5'phos dAdenosyl +def: "modification from DeltaMass" [DeltaMass:295] +comment: From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01130 +name: SucPhencarb Lysyl +def: "modification from DeltaMass" [DeltaMass:297] +comment: From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01131 +name: 5'phos dGuanosyl +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 329 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01132 +name: 5'phos Adenosinyl +def: "OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 329 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01133 +name: S-12-hydroxyfarnesyl-L-cysteine methyl ester +def: "A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester." [PubMed:17790543, RESID:AA0103#var, RESID:AA0105#var] +synonym: "S12HyFarnOMeCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "234.38" +xref: DiffFormula: "C 16 H 26 N 0 O 1 S 0" +xref: DiffMono: "234.198365" +xref: Formula: "C 19 H 32 N 1 O 3 S 1" +xref: MassAvg: "354.53" +xref: MassMono: "354.210290" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00905 ! modified L-cysteine residue +relationship: has_functional_parent MOD:00112 ! S-12-hydroxyfarnesyl-L-cysteine +relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester + +[Term] +id: MOD:01134 +name: fluorescein labelling of peptide N-terminal using NHS ester +def: "modification from DeltaMass" [DeltaMass:306] +comment: From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01135 +name: Hex-HexNAc +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 365 with no citation. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01136 +name: dioctyl phthalate +def: "modification from DeltaMass" [DeltaMass:309] +comment: From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01137 +name: N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine +def: "A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine." [DeltaMass:310] +comment: From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534 +synonym: "PMC lysyl" EXACT DeltaMass-label [] +synonym: "PmcLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "266.36" +xref: DiffFormula: "C 14 H 18 O 3 S 1" +xref: DiffMono: "266.097665" +xref: Formula: "C 20 H 30 N 2 O 4 S 1" +xref: MassAvg: "394.53" +xref: MassMono: "394.192628" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01120 ! 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue + +[Term] +id: MOD:01138 +name: Aedans Cystenyl +def: "modification from DeltaMass" [DeltaMass:311] +comment: [probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01139 +name: dioctyl phthalate sodium adduct +def: "modification from DeltaMass" [DeltaMass:312] +comment: From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01140 +name: diiodinated tyrosine +def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms." [DeltaMass:0, OMSSA:35, PubMed:15627961, UniMod:130#Y] +subset: PSI-MOD-slim +synonym: "3,5-Diiodination (of Tyrosine)" EXACT DeltaMass-label [] +synonym: "di-Iodination" RELATED UniMod-description [] +synonym: "diiodinationy" EXACT OMSSA-label [] +synonym: "Diiodo" RELATED PSI-MS-label [] +synonym: "I2Tyr" EXACT PSI-MOD-label [] +xref: DiffAvg: "251.79" +xref: DiffFormula: "C 0 H -2 I 2 N 0 O 0" +xref: DiffMono: "251.793295" +xref: Formula: "C 9 H 7 I 2 N 1 O 2" +xref: MassAvg: "414.97" +xref: MassMono: "414.856624" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00501 ! diiodinated residue +is_a: MOD:00998 ! iodinated tyrosine + +[Term] +id: MOD:01141 +name: omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine +def: "A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine." [DeltaMass:314] +comment: From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547 +synonym: "PMC arginyl" EXACT DeltaMass-label [] +synonym: "PmcArg" EXACT PSI-MOD-label [] +xref: DiffAvg: "266.36" +xref: DiffFormula: "C 14 H 18 O 3 S 1" +xref: DiffMono: "266.097665" +xref: Formula: "C 20 H 30 N 4 O 4 S 1" +xref: MassAvg: "422.54" +xref: MassMono: "422.198776" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01120 ! 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue + +[Term] +id: MOD:01142 +name: S-15,16-dihydrobiliverdin-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin." [PubMed:10430868, PubMed:15504407, PubMed:1559975, PubMed:3208761, RESID:AA0428] +synonym: "(16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione" EXACT RESID-systematic [] +synonym: "15,16-Dhbv" EXACT RESID-alternate [] +synonym: "15,16-dihydrobiliverdin cysteine adduct" EXACT RESID-alternate [] +synonym: "15,16-dihydrobiliverdin IXalpha" EXACT RESID-alternate [] +synonym: "18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione" EXACT RESID-alternate [] +synonym: "3'-cysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] +synonym: "3alpha-cysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] +synonym: "BINDING 15,16-dihydrobiliverdin (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "DBV" EXACT RESID-alternate [] +synonym: "S-15,16-dihydrobiliverdin-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "584.67" +xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0" +xref: DiffMono: "584.263485" +xref: Formula: "C 36 H 41 N 5 O 7 S 1" +xref: MassAvg: "687.81" +xref: MassMono: "687.272670" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01143 +name: 15,16-dihydrobiliverdin-bis-L-cysteine +def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin." [PubMed:1559975, PubMed:2222853, PubMed:3208761, PubMed:8420941, RESID:AA0429] +comment: Cross-link 2. +synonym: "(16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione" EXACT RESID-systematic [] +synonym: "15,16-Dhbv" EXACT RESID-alternate [] +synonym: "15,16-dihydrobiliverdin cysteine adduct" EXACT RESID-alternate [] +synonym: "15,16-dihydrobiliverdin IXalpha" EXACT RESID-alternate [] +synonym: "15,16-dihydrobiliverdin-bis-L-cysteine" EXACT RESID-name [] +synonym: "3'',18'-biscysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] +synonym: "3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] +synonym: "8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione" EXACT RESID-alternate [] +synonym: "BINDING 15,16-dihydrobiliverdin (covalent; via 2 links)" EXACT UniProt-feature [] +synonym: "DBV" EXACT RESID-alternate [] +xref: DiffAvg: "584.67" +xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0" +xref: DiffMono: "584.263485" +xref: Formula: "C 39 H 46 N 6 O 8 S 2" +xref: MassAvg: "790.95" +xref: MassMono: "790.281854" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01144 +name: S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine." [DeltaMass:0, PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107#var] +comment: From DeltaMass: Average Mass: 524 +subset: PSI-MOD-slim +synonym: "S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine)" EXACT DeltaMass-label [] +xref: DiffAvg: "550.91" +xref: DiffFormula: "C 35 H 66 N 0 O 4 S 0" +xref: DiffMono: "550.496111" +xref: Formula: "C 38 H 71 N 1 O 5 S 1" +xref: MassAvg: "654.05" +xref: MassMono: "653.505295" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00116 ! S-diacylglycerol-L-cysteine + +[Term] +id: MOD:01145 +name: N-tau-(ADP-ribosyl)diphthamide +def: "A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide." [DeltaMass:0] +comment: From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648 +xref: DiffAvg: "684.51" +xref: DiffFormula: "C 22 H 36 N 7 O 14 P 2" +xref: DiffMono: "684.178999" +xref: FormalCharge: "1+" +xref: Formula: "C 28 H 43 N 10 O 15 P 2" +xref: MassAvg: "821.65" +xref: MassMono: "821.237910" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00909 ! modified L-histidine residue +relationship: derives_from MOD:00049 ! 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine + +[Term] +id: MOD:01146 +name: S-(6-FAD)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine." [DeltaMass:0] +comment: From DeltaMass: Average Mass: 784 with no citation. This modification has not been reported [JSG]. +subset: PSI-MOD-slim +synonym: "FAD" RELATED PSI-MS-label [] +synonym: "S6FADCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0" +xref: DiffMono: "783.141485" +xref: Formula: "C 30 H 36 N 10 O 16 P 2 S 1" +xref: MassAvg: "886.68" +xref: MassMono: "886.150669" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01147 +name: (Hex)3-HexNAc-(dHex)HexNAc +def: "modification from DeltaMass" [DeltaMass:0] +comment: From DeltaMass: Average Mass: 1,039 +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00947 ! DeltaMass + +[Term] +id: MOD:01148 +name: ubiquitinylated lysine +def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin." [PubMed:11125103, PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01875 ! N6-acylated L-lysine +relationship: contains MOD:00134 ! N6-glycyl-L-lysine + +[Term] +id: MOD:01149 +name: sumoylated lysine +def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein." [PubMed:12612601, PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01875 ! N6-acylated L-lysine +relationship: contains MOD:00134 ! N6-glycyl-L-lysine + +[Term] +id: MOD:01150 +name: neddylated lysine +def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein." [PubMed:11125103, PubMed:12612601, PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01875 ! N6-acylated L-lysine +relationship: contains MOD:00134 ! N6-glycyl-L-lysine + +[Term] +id: MOD:01151 +name: phosphorylated residue with neutral loss of phosphate +def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "-97.99" +xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1" +xref: DiffMono: "-97.976895" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00432 ! modified residue with neutral loss of phosphate + +[Term] +id: MOD:01152 +name: carboxylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group." [UniMod:299] +subset: PSI-MOD-slim +synonym: "Carboxy" RELATED UniMod-interim [] +synonym: "Carboxylation" RELATED UniMod-description [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01153 +name: methylthiolated residue +def: "A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group)." [UniMod:39] +subset: PSI-MOD-slim +synonym: "Beta-methylthiolation" RELATED UniMod-description [] +synonym: "Methylthio" RELATED UniMod-interim [] +xref: DiffAvg: "46.09" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" +xref: DiffMono: "45.987721" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01886 ! thiolated residue + +[Term] +id: MOD:01154 +name: pyruvic acid +def: "A protein modification that effectively converts a source amino acid to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127] +subset: PSI-MOD-slim +synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES Pyruvic acid (Cys)" EXACT UniProt-feature [] +synonym: "MOD_RES Pyruvic acid (Ser)" EXACT UniProt-feature [] +synonym: "pyruvic acid" EXACT RESID-name [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 3 H 3 O 2" +xref: MassAvg: "71.06" +xref: MassMono: "71.013304" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "N-term" +is_a: MOD:00769 ! residues isobaric at 71.0-71.1 Da +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01155 +name: lipoconjugated residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01156 +name: protein modification categorized by chemical process +def: "Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00000 ! protein modification + +[Term] +id: MOD:01157 +name: protein modification categorized by amino acid modified +def: "A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00000 ! protein modification + +[Term] +id: MOD:01158 +name: modified L-selenocysteine residue +def: "A protein modification that modifies an L-selenocysteine residue." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "U" +is_a: MOD:00745 ! selenium containing residue +is_a: MOD:01157 ! protein modification categorized by amino acid modified +relationship: derives_from MOD:00031 ! L-selenocysteine residue + +[Term] +id: MOD:01159 +name: peptidoglycanated residue +def: "A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage." [PubMed:18688235] +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00764 ! glycoconjugated residue + +[Term] +id: MOD:01160 +name: deaminated residue +def: "A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen." [UniMod:385] +subset: PSI-MOD-slim +synonym: "Ammonia-loss" RELATED UniMod-interim [] +synonym: "Loss of ammonia" RELATED UniMod-description [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01161 +name: deoxygenated residue +def: "A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms." [PubMed:14235557, UniMod:447] +subset: PSI-MOD-slim +synonym: "Deoxy" RELATED PSI-MS-label [] +synonym: "dOxyRes" EXACT PSI-MOD-label [] +synonym: "reduction" RELATED UniMod-description [] +xref: DiffAvg: "-16.00" +xref: DiffFormula: "C 0 H 0 N 0 O -1" +xref: DiffMono: "-15.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01472 ! reduced residue + +[Term] +id: MOD:01162 +name: fucosylated biantennary +def: "modification from UniMod N-linked glycosylation" [UniMod:308] +synonym: "dHex(1)Hex(5)HexNAc(4)" RELATED PSI-MS-label [] +synonym: "Fucosylated biantennary" RELATED UniMod-description [] +xref: DiffAvg: "1769.62" +xref: DiffFormula: "C 68 H 112 N 4 O 49" +xref: DiffMono: "1768.639516" +xref: Formula: "C 72 H 118 N 6 O 51" +xref: MassAvg: "1883.73" +xref: MassMono: "1882.682443" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00725 ! complex glycosylation + +[Term] +id: MOD:01163 +name: guanylated residue +def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond." [DeltaMass:304, UniMod:413] +comment: From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209. +synonym: "5'phos Guanosyl" EXACT DeltaMass-label [] +synonym: "phospho-guanosine" RELATED UniMod-description [] +synonym: "Phosphoguanosine" RELATED PSI-MS-label [] +xref: DiffAvg: "345.21" +xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1" +xref: DiffMono: "345.047434" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue + +[Term] +id: MOD:01164 +name: riboflavin-phosphoryl +def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond." [UniMod:442] +subset: PSI-MOD-slim +synonym: "FMN" RELATED PSI-MS-label [] +synonym: "O3-(riboflavin phosphoryl)" RELATED UniMod-description [] +xref: DiffAvg: "438.33" +xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1" +xref: DiffMono: "438.094050" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00896 ! FMN modified residue + +[Term] +id: MOD:01165 +name: adenylated residue +def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond." [DeltaMass:0, UniMod:405] +comment: From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329 +subset: PSI-MOD-slim +synonym: "5'phos Adenosinyl" EXACT DeltaMass-label [] +synonym: "AMP binding site" RELATED UniMod-description [] +synonym: "Phosphoadenosine" RELATED PSI-MS-label [] +xref: DiffAvg: "329.21" +xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" +xref: DiffMono: "329.052520" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue + +[Term] +id: MOD:01166 +name: uridylated residue +def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond." [DeltaMass:292, UniMod:417] +comment: From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 +synonym: "5'phos Uridinyl" EXACT DeltaMass-label [] +synonym: "PhosphoUridine" RELATED PSI-MS-label [] +synonym: "uridine phosphodiester" RELATED UniMod-description [] +xref: DiffAvg: "306.17" +xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1" +xref: DiffMono: "306.025302" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00701 ! nucleotide or nucleic acid modified residue + +[Term] +id: MOD:01167 +name: molybdopterin guanine dinucleotide +def: "modification from UniMod" [UniMod:424] +synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] +synonym: "MolybdopterinGD" RELATED PSI-MS-label [] +xref: DiffAvg: "1572.02" +xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4" +xref: DiffMono: "1572.985775" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00744 ! molybdenum pterin containing modification + +[Term] +id: MOD:01168 +name: dehydroalanine +def: "A protein modification that effectively converts a source amino acid residue to dehydroalanine." [PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:6838602, PubMed:7947813, PubMed:8239649, RESID:AA0181] +subset: PSI-MOD-slim +synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] +synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] +synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "anhydroserine" EXACT RESID-alternate [] +synonym: "dehydroalanine" EXACT RESID-name [] +synonym: "Dha" EXACT RESID-alternate [] +synonym: "dHAla" EXACT PSI-MOD-label [] +synonym: "MOD_RES 2,3-didehydroalanine (Cys)" EXACT UniProt-feature [] +synonym: "MOD_RES 2,3-didehydroalanine (Ser)" EXACT UniProt-feature [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 3 H 3 N 1 O 1" +xref: MassAvg: "69.06" +xref: MassMono: "69.021464" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01169 +name: L-3-oxoalanine +def: "A protein modification that effectively converts a source amino acid residue to L-oxoalanine." [DeltaMass:349, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9478923, RESID:AA0185] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate [] +synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer [] +synonym: "L-3-oxoalanine" EXACT RESID-name [] +synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate [] +synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate [] +synonym: "L-serinesemialdehyde" RELATED RESID-misnomer [] +synonym: "MOD_RES 3-oxoalanine (Cys)" EXACT UniProt-feature [] +synonym: "MOD_RES 3-oxoalanine (Ser)" EXACT UniProt-feature [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 3 H 3 N 1 O 2" +xref: MassAvg: "85.06" +xref: MassMono: "85.016378" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01170 +name: pyruvic acid iminylated residue +def: "A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group." [UniMod:422] +synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] +synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] +xref: DiffAvg: "70.05" +xref: DiffFormula: "C 3 H 2 N 0 O 2" +xref: DiffMono: "70.005479" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "N-term" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01171 +name: O-acetyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine." [PubMed:16728640, RESID:AA0423, UniMod:1#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-3-(acetyloxy)-2-aminobutanoic acid" EXACT RESID-systematic [] +synonym: "Acetylation" RELATED UniMod-description [] +synonym: "ACT_SITE O-acetylthreonine intermediate" EXACT UniProt-feature [] +synonym: "MOD_RES O-acetylthreonine" EXACT UniProt-feature [] +synonym: "O-acetyl-L-threonine" EXACT RESID-name [] +synonym: "O-acetylthreonine" EXACT RESID-alternate [] +synonym: "OAcThr" EXACT PSI-MOD-label [] +synonym: "threonine acetate ester" EXACT RESID-alternate [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "C 6 H 9 N 1 O 3" +xref: MassAvg: "143.14" +xref: MassMono: "143.058243" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00644 ! O-acetylated residue +is_a: MOD:01186 ! acetylated L-threonine + +[Term] +id: MOD:01172 +name: N-alanyl-glycosylsphingolipidinositolethanolamine +def: "A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, RESID:AA0424] +synonym: "GSIAla" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-like-anchor amidated alanine" EXACT UniProt-feature [] +synonym: "N-alanyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 5 H 12 N 2 O 5 P 1" +xref: MassAvg: "211.13" +xref: MassMono: "211.048383" +xref: Origin: "A" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00466 ! glycosylsphingolipidinositolated residue +is_a: MOD:00901 ! modified L-alanine residue + +[Term] +id: MOD:01173 +name: N-asparaginyl-glycosylsphingolipidinositolethanolamine +def: "A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, RESID:AA0425] +synonym: "GSIAsn" EXACT PSI-MOD-label [] +synonym: "LIPID GPI-like-anchor amidated asparagine" EXACT UniProt-feature [] +synonym: "N-asparaginyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 6 H 13 N 3 O 6 P 1" +xref: MassAvg: "254.16" +xref: MassMono: "254.054197" +xref: Origin: "N" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00466 ! glycosylsphingolipidinositolated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:01174 +name: S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine." [ChEBI:27485, PubMed:11466314, PubMed:12684535, RESID:AA0426] +synonym: "(2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid" EXACT RESID-alternate [] +synonym: "(5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid" EXACT RESID-systematic [] +synonym: "LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine" EXACT UniProt-feature [] +synonym: "PG-J2Cys" EXACT PSI-MOD-label [] +synonym: "S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "316.44" +xref: DiffFormula: "C 20 H 28 N 0 O 3 S 0" +xref: DiffMono: "316.203845" +xref: Formula: "C 23 H 33 N 1 O 4 S 1" +xref: MassAvg: "419.58" +xref: MassMono: "419.213030" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01155 ! lipoconjugated residue + +[Term] +id: MOD:01175 +name: S-phycourobilin-L-cysteine +def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin." [PubMed:1903388, PubMed:3208761, PubMed:3838747, RESID:AA0427] +synonym: "(2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] +synonym: "18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate [] +synonym: "BINDING Phycourobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] +synonym: "phycourobilin cysteine adduct" EXACT RESID-alternate [] +synonym: "PUB" EXACT RESID-alternate [] +synonym: "PUBCys" EXACT PSI-MOD-label [] +synonym: "S-phycourobilin-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "586.69" +xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" +xref: DiffMono: "586.279135" +xref: Formula: "C 36 H 43 N 5 O 7 S 1" +xref: MassAvg: "689.83" +xref: MassMono: "689.288320" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00700 ! tetrapyrrole modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01176 +name: L-dehydrolysinonorleucine +def: "A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine." [PubMed:16929109, RESID:AA0430] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "6-(N6-L-didehydrolysino)-L-norleucine" EXACT RESID-alternate [] +synonym: "CROSSLNK Dehydrolysinonorleucine (Lys-Lys)" EXACT UniProt-feature [] +synonym: "dehydrolysinorleucine [misspelling]" EXACT RESID-alternate [] +synonym: "dehydrolysylnorleucine" EXACT RESID-alternate [] +synonym: "didehydrolysinonorleucine" EXACT RESID-alternate [] +synonym: "L-dehydrolysinonorleucine" EXACT RESID-name [] +synonym: "N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine" EXACT RESID-alternate [] +synonym: "XLNK6NleN6Lys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-19.05" +xref: DiffFormula: "C 0 H -5 N -1 O 0" +xref: DiffMono: "-19.042199" +xref: Formula: "C 12 H 19 N 3 O 2" +xref: MassAvg: "237.30" +xref: MassMono: "237.147727" +xref: Origin: "K, K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01177 +name: 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine." [PubMed:16760471, RESID:AA0431] +synonym: "(S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] +synonym: "1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine" EXACT RESID-name [] +synonym: "1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine" EXACT RESID-alternate [] +synonym: "MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT UniProt-feature [] +synonym: "N(epsilon)-histidine dihydroxyacetone adduct" EXACT RESID-alternate [] +synonym: "N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT RESID-alternate [] +synonym: "NtauDHAHis" EXACT PSI-MOD-label [] +synonym: "tele-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT RESID-alternate [] +xref: DiffAvg: "90.08" +xref: DiffFormula: "C 3 H 6 N 0 O 3" +xref: DiffMono: "90.031694" +xref: Formula: "C 9 H 13 N 3 O 4" +xref: MassAvg: "227.22" +xref: MassMono: "227.090606" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01178 +name: S-(aspart-4-yloxy) thiocarbonate +def: "A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate." [PubMed:16627948, RESID:AA0432] +comment: This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. +synonym: "(2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "4-aspartyloxysulfanylcarbonate" EXACT RESID-alternate [] +synonym: "AspOSCO2H" EXACT PSI-MOD-label [] +synonym: "O-carboxysulfanyl-4-oxo-L-homoserine" EXACT RESID-alternate [] +synonym: "S-(aspart-4-yloxy) thiocarbonate" EXACT RESID-name [] +xref: DiffAvg: "76.07" +xref: DiffFormula: "C 1 H 0 N 0 O 2 S 1" +xref: DiffMono: "75.961900" +xref: Formula: "C 5 H 5 N 1 O 5 S 1" +xref: MassAvg: "191.16" +xref: MassMono: "190.988843" +xref: Origin: "D" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01179 +name: N,N-dimethyl-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine." [PubMed:17691833, PubMed:387091, RESID:AA0433] +synonym: "(S)-1-carboxy-N,N-dimethylaminoethane" EXACT RESID-alternate [] +synonym: "(S)-2-(dimethylamino)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N,N-dimethylalanine" EXACT UniProt-feature [] +synonym: "N,N-dimethyl-L-alanine" EXACT RESID-name [] +synonym: "N,N-dimethylalanine" EXACT RESID-alternate [] +synonym: "NMe2Ala" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 5 H 10 N 1 O 1" +xref: MassAvg: "100.14" +xref: MassMono: "100.076239" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01461 ! N-methylated alanine +is_a: MOD:01686 ! alpha-amino dimethylated residue + +[Term] +id: MOD:01180 +name: 2-hydroxyglycine observational artifact +def: "A protein modification that effectively converts a glycine residue to 2-hydroxyglycine." [ChEBI:38048, PubMed:16178056, PubMed:17431180, PubMed:17823333, RESID:AA0434] +comment: CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG]. +synonym: "2-hydroxyglycine" EXACT RESID-name [] +synonym: "2HyGly" EXACT PSI-MOD-label [] +synonym: "alpha-hydroxyglycine" EXACT RESID-alternate [] +synonym: "amino(hydroxy)acetic acid" EXACT RESID-systematic [] +synonym: "aminohydroxyacetic acid" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 2 H 3 N 1 O 2" +xref: MassAvg: "73.05" +xref: MassMono: "73.016378" +xref: Origin: "G" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:01181 +name: L-aspartic acid 4-methyl ester +def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester." [OMSSA:69, PubMed:1556110, PubMed:16888766, PubMed:9629898, RESID:AA0435, UniMod:34#D] +comment: CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG]. +synonym: "(2S)-2-amino-4-methoxy-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-aminobutanedioic acid 4-methyl ester" EXACT RESID-alternate [] +synonym: "4-methyl L-2-aminosuccinic acid" EXACT RESID-alternate [] +synonym: "4-methyl L-aspartate" EXACT RESID-alternate [] +synonym: "4-methyl L-hydrogen aspartate" EXACT RESID-alternate [] +synonym: "aspartic acid 4-methyl ester" EXACT RESID-alternate [] +synonym: "aspartic acid beta-methyl ester" EXACT RESID-alternate [] +synonym: "L-aspartic acid 4-methyl ester" EXACT RESID-name [] +synonym: "meesterd" EXACT OMSSA-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "O4MeAsp" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00393 ! O-methylated residue +is_a: MOD:01681 ! monomethylated L-aspartic acid + +[Term] +id: MOD:01182 +name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD +def: "A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD." [PubMed:, RESID:AA0436] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine" EXACT RESID-systematic [] +synonym: "6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD" EXACT RESID-alternate [] +synonym: "6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD" EXACT RESID-alternate [] +synonym: "6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD" EXACT RESID-alternate [] +synonym: "6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD" EXACT RESID-alternate [] +synonym: "6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD" EXACT RESID-name [] +synonym: "BINDING FAD (covalent; via 2 links)" EXACT UniProt-feature [] +synonym: "BINDING FAD (covalent; via 2 links, pros nitrogen)" EXACT UniProt-feature [] +synonym: "SCys6-NprosHis8a-FAD" EXACT PSI-MOD-label [] +xref: DiffAvg: "781.52" +xref: DiffFormula: "C 27 H 29 N 9 O 15 P 2 S 0" +xref: DiffMono: "781.125835" +xref: Formula: "C 36 H 41 N 13 O 17 P 2 S 1" +xref: MassAvg: "1021.81" +xref: MassMono: "1021.193931" +xref: Origin: "C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01621 ! flavin crosslinked residues + +[Term] +id: MOD:01183 +name: L-selenocystine (oxidized selenocysteine) (Sec-Sec) +def: "A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine," [ChEBI:28553, PubMed:17715293, PubMed:6076213, RESID:AA0437] +comment: Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184. +subset: PSI-MOD-slim +synonym: "(R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "3,3'-diselenobis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-diselenobisalanine" EXACT RESID-alternate [] +synonym: "3,3'-diselenodialanine" EXACT RESID-alternate [] +synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide" EXACT RESID-alternate [] +synonym: "beta,beta'-diselenodialanine" EXACT RESID-alternate [] +synonym: "bis(alpha-aminopropionic acid)-beta-diselenide" EXACT RESID-alternate [] +synonym: "bis(beta-amino-beta-carboxyethyl)diselenide" EXACT RESID-alternate [] +synonym: "CROSSLNK Selenocystine (Sec-Sec)" EXACT UniProt-feature [] +synonym: "diselenocysteine" EXACT RESID-alternate [] +synonym: "L-selenocystine" EXACT RESID-name [] +synonym: "Sec2" EXACT PSI-MOD-label [] +synonym: "selenium cystine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 Se 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 2 Se 2" +xref: MassAvg: "298.08" +xref: MassMono: "299.891620" +xref: Origin: "U, U" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:01158 ! modified L-selenocysteine residue + +[Term] +id: MOD:01184 +name: L-selenocystine (selenium disubstituted L-cystine) +def: "A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine." [PubMed:17715293, RESID:AA0437#CYS2] +comment: Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183. +synonym: "(R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "3,3'-diselenobis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-diselenobisalanine" EXACT RESID-alternate [] +synonym: "3,3'-diselenodialanine" EXACT RESID-alternate [] +synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide" EXACT RESID-alternate [] +synonym: "beta,beta'-diselenodialanine" EXACT RESID-alternate [] +synonym: "bis(alpha-aminopropionic acid)-beta-diselenide" EXACT RESID-alternate [] +synonym: "bis(beta-amino-beta-carboxyethyl)diselenide" EXACT RESID-alternate [] +synonym: "CROSSLNK Selenocystine (Sec-Sec)" EXACT UniProt-feature [] +synonym: "diselenocysteine" EXACT RESID-alternate [] +synonym: "L-selenocystine" EXACT RESID-name [] +synonym: "Se2(S2)Cys2" EXACT PSI-MOD-label [] +synonym: "selenium cystine" EXACT RESID-alternate [] +xref: DiffAvg: "91.81" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S -2 Se 2" +xref: DiffMono: "93.873250" +xref: Formula: "C 6 H 8 N 2 O 2 Se 2" +xref: MassAvg: "298.08" +xref: MassMono: "299.891620" +xref: Origin: "C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00007 ! selenium substitution for sulfur +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01185 +name: 4-amidated L-aspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to L-asparagine." [PubMed:17962566, RESID:AA0003#ASP] +synonym: "(2S)-2-amino-4-butanediamic acid" EXACT RESID-systematic [] +synonym: "2,4-bis(azanyl)-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "2,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-carbamoylpropanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-4-butanediamic acid" EXACT RESID-alternate [] +synonym: "2-aminosuccinamic acid" EXACT RESID-alternate [] +synonym: "2-aminosuccinic acid 4-amide" EXACT RESID-alternate [] +synonym: "4NAsp" EXACT PSI-MOD-label [] +synonym: "alpha-amino-beta-carbamylpropionic acid" EXACT RESID-alternate [] +synonym: "alpha-aminosuccinamic acid" EXACT RESID-alternate [] +synonym: "aspartic acid 4-amide" EXACT RESID-alternate [] +synonym: "aspartic acid beta-amide" EXACT RESID-alternate [] +synonym: "beta-asparagine" EXACT RESID-alternate [] +synonym: "L-asparagine" EXACT RESID-name [] +synonym: "MOD_RES Amidated aspartic acid" EXACT UniProt-feature [] +xref: DiffAvg: "-0.98" +xref: DiffFormula: "C 0 H 1 N 1 O -1" +xref: DiffMono: "-0.984016" +xref: Formula: "C 4 H 6 N 2 O 2" +xref: MassAvg: "114.10" +xref: MassMono: "114.042927" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00012 ! L-asparagine residue +is_a: MOD:00674 ! amidated residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01186 +name: acetylated L-threonine +def: "A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "AcThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "T" +xref: Source: "natural" +is_a: MOD:00394 ! acetylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01187 +name: L-pyrrolysine residue +def: "A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification." [ChEBI:21860, PubMed:11435424, PubMed:12029131, PubMed:12029132, PubMed:15314242, PubMed:16096277, RESID:AA0321, UniMod:435] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid" EXACT RESID-alternate [] +synonym: "L-pyrrolysine" EXACT RESID-name [] +synonym: "monomethylamine methyltransferase cofactor lysine adduct" EXACT RESID-alternate [] +synonym: "N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine" EXACT RESID-alternate [] +synonym: "NON_STD Pyrrolysine" EXACT UniProt-feature [] +synonym: "Pyl" EXACT PSI-MOD-label [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 12 H 19 N 3 O 2" +xref: MassAvg: "237.30" +xref: MassMono: "237.147727" +xref: Origin: "O" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00868 ! natural, non-standard encoded residue + +[Term] +id: MOD:01188 +name: N-ethyl iodoacetamide-d5 - site Y +def: "modification from UniMod Isotopic label -" [PubMed:11710128, PubMed:12766232, PubMed:3155470, PubMed:957432, UniMod:212#Y] +synonym: "N-ethyl iodoacetamide-d5" RELATED UniMod-description [] +synonym: "NEIAA:2H(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "90.08" +xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1" +xref: DiffMono: "90.084148" +xref: Formula: "C 13 (1)H 11 (2)H 5 N 2 O 3" +xref: MassAvg: "253.15" +xref: MassMono: "253.147476" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00562 ! N-ethyl iodoacetamide-d5 + +[Term] +id: MOD:01189 +name: N-ethyl iodoacetamide-d5 - site C +def: "modification from UniMod Isotopic label -" [PubMed:12766232, UniMod:212#C] +synonym: "N-ethyl iodoacetamide-d5" RELATED UniMod-description [] +synonym: "NEIAA:2H(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "90.08" +xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1" +xref: DiffMono: "90.084148" +xref: Formula: "C 7 (1)H 7 (2)H 5 N 2 O 2 S 1" +xref: MassAvg: "193.09" +xref: MassMono: "193.093332" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00562 ! N-ethyl iodoacetamide-d5 + +[Term] +id: MOD:01190 +name: dibromo +def: "Modification from UniMod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006." [UniMod:534] +synonym: "Dibromo" RELATED PSI-MS-label [] +synonym: "Dibromo" RELATED UniMod-description [] +xref: DiffAvg: "157.79" +xref: DiffFormula: "Br 2 H -2" +xref: DiffMono: "155.821024" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Y" +xref: Source: "none" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01191 +name: N-ethyl iodoacetamide-d0 - site C +def: "modification from UniMod Isotopic label -" [PubMed:12766232, UniMod:211#C] +synonym: "N-ethyl iodoacetamide-d0" RELATED UniMod-description [] +synonym: "NEIAA" RELATED PSI-MS-label [] +xref: DiffAvg: "85.11" +xref: DiffFormula: "C 4 H 7 N 1 O 1" +xref: DiffMono: "85.052764" +xref: Formula: "C 7 H 12 N 2 O 2 S 1" +xref: MassAvg: "188.25" +xref: MassMono: "188.061949" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00561 ! N-ethyl iodoacetamide-d0 + +[Term] +id: MOD:01192 +name: N-ethyl iodoacetamide-d0 - site Y +def: "modification from UniMod Isotopic label -" [PubMed:11760118, PubMed:12766232, UniMod:211#Y] +synonym: "N-ethyl iodoacetamide-d0" RELATED UniMod-description [] +synonym: "NEIAA" RELATED PSI-MS-label [] +xref: DiffAvg: "85.11" +xref: DiffFormula: "C 4 H 7 N 1 O 1" +xref: DiffMono: "85.052764" +xref: Formula: "C 13 H 16 N 2 O 3" +xref: MassAvg: "248.28" +xref: MassMono: "248.116092" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00561 ! N-ethyl iodoacetamide-d0 + +[Term] +id: MOD:01193 +name: phosphorylation to pyridyl thiol - site T +def: "modification from UniMod Chemical derivative -" [PubMed:1093385, UniMod:264#T] +synonym: "PET" RELATED PSI-MS-label [] +synonym: "phosphorylation to pyridyl thiol" RELATED UniMod-description [] +xref: DiffAvg: "121.20" +xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1" +xref: DiffMono: "121.035006" +xref: Formula: "C 11 H 14 N 2 O 1 S 1" +xref: MassAvg: "222.31" +xref: MassMono: "222.082684" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00586 ! phosphorylation to pyridyl thiol + +[Term] +id: MOD:01194 +name: phosphorylation to pyridyl thiol - site S +def: "modification from UniMod Chemical derivative -" [PubMed:15279557, UniMod:264#S] +synonym: "PET" RELATED PSI-MS-label [] +synonym: "phosphorylation to pyridyl thiol" RELATED UniMod-description [] +xref: DiffAvg: "121.20" +xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1" +xref: DiffMono: "121.035006" +xref: Formula: "C 10 H 12 N 2 O 1 S 1" +xref: MassAvg: "208.28" +xref: MassMono: "208.067034" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00586 ! phosphorylation to pyridyl thiol + +[Term] +id: MOD:01195 +name: benzoyl labeling reagent light form - site K +def: "modification from UniMod Isotopic label -" [PubMed:11813307, PubMed:12777388, PubMed:15456300, UniMod:136#K] +synonym: "Benzoyl" RELATED PSI-MS-label [] +synonym: "labeling reagent light form (N-term & K)" RELATED UniMod-description [] +xref: DiffAvg: "104.11" +xref: DiffFormula: "C 7 H 4 O 1" +xref: DiffMono: "104.026215" +xref: Formula: "C 13 H 16 N 2 O 2" +xref: MassAvg: "232.28" +xref: MassMono: "232.121178" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00505 ! benzoyl labeling reagent light form (N-term and K) + +[Term] +id: MOD:01196 +name: 5-dimethylaminonaphthalene-1-sulfonyl - site K +def: "OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654." [UniMod:139] +synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] +synonym: "Dansyl" RELATED PSI-MS-label [] +xref: DiffAvg: "233.29" +xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" +xref: DiffMono: "233.051050" +xref: Formula: "C 18 H 23 N 3 O 3 S 1" +xref: MassAvg: "361.46" +xref: MassMono: "361.146013" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01197 +name: N-heptosyl-L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine." [UniMod:490#Q] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "C 12 H 20 N 2 O 8" +xref: MassAvg: "320.30" +xref: MassMono: "320.121966" +xref: Origin: "Q" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00925 ! heptosylated residue + +[Term] +id: MOD:01198 +name: O-heptosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine." [UniMod:490#S] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "C 10 H 17 N 1 O 8" +xref: MassAvg: "279.25" +xref: MassMono: "279.095417" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00925 ! heptosylated residue + +[Term] +id: MOD:01199 +name: N-heptosyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine." [UniMod:490#R] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "C 13 H 24 N 4 O 7" +xref: MassAvg: "348.36" +xref: MassMono: "348.164499" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00925 ! heptosylated residue + +[Term] +id: MOD:01200 +name: O-heptosyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine." [UniMod:490#T] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "C 11 H 19 N 1 O 8" +xref: MassAvg: "293.27" +xref: MassMono: "293.111067" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00925 ! heptosylated residue + +[Term] +id: MOD:01201 +name: N6-heptosyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine." [UniMod:490#K] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "C 13 H 24 N 2 O 7" +xref: MassAvg: "320.34" +xref: MassMono: "320.158351" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00925 ! heptosylated residue + +[Term] +id: MOD:01202 +name: N-heptosyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine." [UniMod:490#N] +comment: From UniMod with no citation [JSG]. +synonym: "Hep" RELATED PSI-MS-label [] +synonym: "Heptose" RELATED UniMod-description [] +xref: DiffAvg: "192.17" +xref: DiffFormula: "C 7 H 12 O 6" +xref: DiffMono: "192.063388" +xref: Formula: "C 11 H 18 N 2 O 8" +xref: MassAvg: "306.27" +xref: MassMono: "306.106316" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00925 ! heptosylated residue + +[Term] +id: MOD:01203 +name: N6-(pyridylacetyl)lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine." [PubMed:9276974, UniMod:25#K] +comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. +synonym: "Pyridylacetyl" RELATED PSI-MS-label [] +synonym: "pyridylacetyl" RELATED UniMod-description [] +xref: DiffAvg: "119.12" +xref: DiffFormula: "C 7 H 5 N 1 O 1" +xref: DiffMono: "119.037114" +xref: Formula: "C 13 H 17 N 3 O 2" +xref: MassAvg: "247.30" +xref: MassMono: "247.132077" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00418 ! pyridylacetylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01204 +name: prompt loss of methanethiol from oxidixed methionine +def: "modification from UniMod Artifact -" [PubMed:9004526, UniMod:526] +synonym: "Dethiomethyl" RELATED PSI-MS-label [] +synonym: "Prompt loss of side chain from oxidised Met" RELATED UniMod-description [] +xref: DiffAvg: "-48.10" +xref: DiffFormula: "C -1 H -4 S -1" +xref: DiffMono: "-48.003371" +xref: Formula: "C 4 H 5 N 1 O 1 S 0" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:01205 +name: Hex1HexNAc1NeuAc2 O-glycosylated serine +def: "A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [PubMed:7949339, UniMod:160#S] +synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] +xref: DiffAvg: "947.85" +xref: DiffFormula: "C 36 H 57 N 3 O 26" +xref: DiffMono: "947.323029" +xref: Formula: "C 39 H 62 N 4 O 28" +xref: MassAvg: "1034.93" +xref: MassMono: "1034.355057" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01206 +name: Hex1HexNAc1NeuAc2 O-glycosylated threonine +def: "A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [UniMod:160#T] +synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] +xref: DiffAvg: "947.85" +xref: DiffFormula: "C 36 H 57 N 3 O 26" +xref: DiffMono: "947.323029" +xref: Formula: "C 40 H 64 N 4 O 28" +xref: MassAvg: "1048.95" +xref: MassMono: "1048.370707" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01207 +name: Hex1HexNAc1NeuAc2 N4-glycosylated asparagine +def: "A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [UniMod:160#N] +synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] +xref: DiffAvg: "947.85" +xref: DiffFormula: "C 36 H 57 N 3 O 26" +xref: DiffMono: "947.323029" +xref: Formula: "C 40 H 63 N 5 O 28" +xref: MassAvg: "1061.95" +xref: MassMono: "1061.365956" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:01208 +name: copper(1+) carboxylate C-terminal residue +def: "A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt." [UniMod:531#C-term] +synonym: "Cation:Cu[I]" RELATED PSI-MS-label [] +synonym: "cuprous salt" EXACT PSI-MOD-alternate [] +synonym: "Replacement of proton by copper" RELATED UniMod-description [] +xref: DiffAvg: "62.54" +xref: DiffFormula: "Cu 1 H -1" +xref: DiffMono: "61.921772" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "C-term" +is_a: MOD:00742 ! copper containing modified residue + +[Term] +id: MOD:01209 +name: copper(1+) L-aspartate +def: "A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt." [UniMod:531#D] +synonym: "Cation:Cu[I]" RELATED PSI-MS-label [] +synonym: "cuprous salt" EXACT PSI-MOD-alternate [] +synonym: "Replacement of proton by copper" RELATED UniMod-description [] +xref: DiffAvg: "62.54" +xref: DiffFormula: "Cu 1 H -1" +xref: DiffMono: "61.921772" +xref: Formula: "C 4 Cu 1 H 4 N 1 O 3" +xref: MassAvg: "177.63" +xref: MassMono: "176.948715" +xref: Origin: "D" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00742 ! copper containing modified residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01210 +name: copper(1+) L-glutamate +def: "A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt." [UniMod:531#E] +synonym: "Cation:Cu[I]" RELATED PSI-MS-label [] +synonym: "cuprous salt" EXACT PSI-MOD-alternate [] +synonym: "Replacement of proton by copper" RELATED UniMod-description [] +xref: DiffAvg: "62.54" +xref: DiffFormula: "Cu 1 H -1" +xref: DiffMono: "61.921772" +xref: Formula: "C 5 Cu 1 H 6 N 1 O 3" +xref: MassAvg: "191.65" +xref: MassMono: "190.964366" +xref: Origin: "E" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00742 ! copper containing modified residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01211 +name: N6-(morpholine-2-acetyl)-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine." [PubMed:10446193, UniMod:29#K] +comment: The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. +synonym: "N-Succinimidyl-2-morpholine acetate" RELATED UniMod-description [] +synonym: "N-succinimidylmorpholine-2-acetate N6-derivatized lysine" EXACT PSI-MOD-alternate [] +synonym: "SMA" RELATED PSI-MS-label [] +xref: DiffAvg: "127.14" +xref: DiffFormula: "C 6 H 9 N 1 O 2" +xref: DiffMono: "127.063329" +xref: Formula: "C 12 H 21 N 3 O 3" +xref: MassAvg: "255.32" +xref: MassMono: "255.158292" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01813 ! morpholine-2-acetylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01212 +name: iodoacetamide N6-derivatized lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine." [OMSSA:27, PubMed:11510821, PubMed:12422359, PubMed:12686488, UniMod:4#K] +subset: PSI-MOD-slim +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "carbamidomethylk" EXACT OMSSA-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +synonym: "N6-(2-amino-2-oxoethyl)lysine" EXACT PSI-MOD-alternate [] +synonym: "N6-(carbamoylmethyl)lysine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "C 8 H 15 N 3 O 2" +xref: MassAvg: "185.23" +xref: MassMono: "185.116427" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01213 +name: iodoacetamide derivatized histidine +def: "A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine." [OMSSA:28, PubMed:11510821, PubMed:12422359, PubMed:15627961, PubMed:2026710, UniMod:4#H] +subset: PSI-MOD-slim +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "carbamidometylh" EXACT OMSSA-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "C 8 H 10 N 4 O 2" +xref: MassAvg: "194.19" +xref: MassMono: "194.080376" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01214 +name: iodoacetamide - site C +def: "modification from UniMod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060." [PubMed:10504701, PubMed:11510821, PubMed:12422359, UniMod:4#C] +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01215 +name: iodoacetamide derivatized aspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate." [OMSSA:29, PubMed:11510821, PubMed:12422359, PubMed:16526082, UniMod:4#D] +subset: PSI-MOD-slim +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "carbamidomethyld" EXACT OMSSA-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "C 6 H 8 N 2 O 4" +xref: MassAvg: "172.14" +xref: MassMono: "172.048407" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01216 +name: iodoacetamide derivatized glutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate." [OMSSA:30, PubMed:11510821, PubMed:12422359, UniMod:4#E] +subset: PSI-MOD-slim +synonym: "Carbamidomethyl" RELATED PSI-MS-label [] +synonym: "carbamidomethyle" EXACT OMSSA-label [] +synonym: "Iodoacetamide derivative" RELATED UniMod-description [] +xref: DiffAvg: "57.05" +xref: DiffFormula: "C 2 H 3 N 1 O 1" +xref: DiffMono: "57.021464" +xref: Formula: "C 7 H 10 N 2 O 4" +xref: MassAvg: "186.17" +xref: MassMono: "186.064057" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01217 +name: Sulfanilic Acid (SA), light C12 - site D +def: "modification from UniMod Isotopic label -" [PubMed:12872131, UniMod:285#D] +synonym: "Light Sulfanilic Acid (SA) C12" RELATED UniMod-description [] +synonym: "SulfanilicAcid" RELATED PSI-MS-label [] +xref: DiffAvg: "155.00" +xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1" +xref: DiffMono: "155.004099" +xref: Formula: "(12)C 10 H 10 N 2 O 5 S 1" +xref: MassAvg: "270.03" +xref: MassMono: "270.031042" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00605 ! Sulfanilic Acid (SA), light C12 + +[Term] +id: MOD:01218 +name: Sulfanilic Acid (SA), light C12 - site E +def: "modification from UniMod Isotopic label -" [PubMed:15283597, UniMod:285#E] +synonym: "Light Sulfanilic Acid (SA) C12" RELATED UniMod-description [] +synonym: "SulfanilicAcid" RELATED PSI-MS-label [] +xref: DiffAvg: "155.00" +xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1" +xref: DiffMono: "155.004099" +xref: Formula: "(12)C 11 H 12 N 2 O 5 S 1" +xref: MassAvg: "284.05" +xref: MassMono: "284.046692" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00605 ! Sulfanilic Acid (SA), light C12 + +[Term] +id: MOD:01219 +name: Sulfanilic Acid (SA), heavy C13 - site D +def: "modification from UniMod Chemical derivative -" [PubMed:9254591, PubMed:9750125, UniMod:286#D] +synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED UniMod-description [] +synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "161.02" +xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1" +xref: DiffMono: "161.024228" +xref: Formula: "(12)C 4 (13)C 6 H 10 N 2 O 5 S 1" +xref: MassAvg: "276.05" +xref: MassMono: "276.051171" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00606 ! Sulfanilic Acid (SA), heavy C13 + +[Term] +id: MOD:01220 +name: Sulfanilic Acid (SA), heavy C13 - site E +def: "modification from UniMod Chemical derivative -" [PubMed:15121203, PubMed:9254591, UniMod:286#E] +synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED UniMod-description [] +synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "161.02" +xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1" +xref: DiffMono: "161.024228" +xref: Formula: "(12)C 5 (13)C 6 H 12 N 2 O 5 S 1" +xref: MassAvg: "290.07" +xref: MassMono: "290.066822" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00606 ! Sulfanilic Acid (SA), heavy C13 + +[Term] +id: MOD:01221 +name: O-formyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine." [PubMed:11861642, PubMed:15799070, UniMod:122#T] +comment: From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). +synonym: "Formyl" RELATED PSI-MS-label [] +synonym: "Formylation" RELATED UniMod-description [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01483 ! O-formylated residue + +[Term] +id: MOD:01222 +name: O-formyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-formyl-L-serine." [PubMed:15627961, PubMed:15799070, UniMod:122#S] +comment: From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). +synonym: "Formyl" RELATED PSI-MS-label [] +synonym: "Formylation" RELATED UniMod-description [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01483 ! O-formylated residue + +[Term] +id: MOD:01223 +name: thioacylation of primary amines - site N-term +def: "modification from UniMod Other -" [OMSSA:41, PubMed:11710128, PubMed:3155470, PubMed:957432, UniMod:126#N-term] +comment: This UniMod entry is misdescribed as "thioacylation" [JSG]. +synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED UniMod-alternate [] +synonym: "ntermpeptioacetyl" EXACT OMSSA-label [] +synonym: "Thioacyl" RELATED PSI-MS-label [] +synonym: "thioacylation of primary amines (N-term and Lys)" RELATED UniMod-description [] +xref: DiffAvg: "88.12" +xref: DiffFormula: "C 3 H 4 O 1 S 1" +xref: DiffMono: "87.998286" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00497 ! 3-sulfanylpropanoyl (N-term and Lys) + +[Term] +id: MOD:01224 +name: thioacylation of primary amines - site K +def: "modification from UniMod Other -" [OMSSA:40, PubMed:11710128, PubMed:3155470, PubMed:957432, UniMod:126#K] +comment: This UniMod entry is misdescribed as "thioacylation" [JSG]. +synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED UniMod-alternate [] +synonym: "thioacetylk" EXACT OMSSA-label [] +synonym: "Thioacyl" RELATED PSI-MS-label [] +synonym: "thioacylation of primary amines (N-term and Lys)" RELATED UniMod-description [] +xref: DiffAvg: "88.12" +xref: DiffFormula: "C 3 H 4 O 1 S 1" +xref: DiffMono: "87.998286" +xref: Formula: "C 9 H 16 N 2 O 2 S 1" +xref: MassAvg: "216.30" +xref: MassMono: "216.093249" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00497 ! 3-sulfanylpropanoyl (N-term and Lys) + +[Term] +id: MOD:01225 +name: monofluorinated L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine." [OMSSA:46, PubMed:8069568, UniMod:127#Y] +comment: From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. +synonym: "Fluoro" RELATED PSI-MS-label [] +synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] +synonym: "phef" EXACT OMSSA-label [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "F 1 H -1" +xref: DiffMono: "17.990578" +xref: Formula: "C 9 F 1 H 8 N 1 O 2" +xref: MassAvg: "181.17" +xref: MassMono: "181.053907" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00498 ! fluorinated residue +is_a: MOD:00985 ! halogenated tyrosine + +[Term] +id: MOD:01226 +name: monofluorinated L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan." [PubMed:8069568, UniMod:127#W] +comment: From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. +synonym: "Fluoro" RELATED PSI-MS-label [] +synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "F 1 H -1" +xref: DiffMono: "17.990578" +xref: Formula: "C 11 F 1 H 9 N 2 O 1" +xref: MassAvg: "204.20" +xref: MassMono: "204.069891" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00498 ! fluorinated residue +is_a: MOD:01068 ! halogenated tryptophan + +[Term] +id: MOD:01227 +name: monofluorinated L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine." [DeltaMass:181, OMSSA:46, PubMed:8069568, UniMod:127#F] +comment: From UniMod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG]. +synonym: "Fluoro" RELATED PSI-MS-label [] +synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] +synonym: "phef" EXACT OMSSA-label [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" +xref: DiffMono: "17.990578" +xref: Formula: "C 9 F 1 H 8 N 1 O 1" +xref: MassAvg: "165.17" +xref: MassMono: "165.058992" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00498 ! fluorinated residue +is_a: MOD:01066 ! halogenated phenylalanine + +[Term] +id: MOD:01228 +name: monoiodinated tyrosine +def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom." [DeltaMass:0, OMSSA:65, PubMed:1326520, PubMed:15627961, PubMed:2026710, UniMod:129#Y] +comment: From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG]. +subset: PSI-MOD-slim +synonym: "I1Tyr" EXACT PSI-MOD-label [] +synonym: "Iodination" RELATED UniMod-description [] +synonym: "iodinationy" EXACT OMSSA-label [] +synonym: "Iodo" RELATED PSI-MS-label [] +xref: DiffAvg: "125.90" +xref: DiffFormula: "H -1 I 1" +xref: DiffMono: "125.896648" +xref: Formula: "C 9 H 8 I 1 N 1 O 2" +xref: MassAvg: "289.07" +xref: MassMono: "288.959976" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00500 ! monoiodinated residue +is_a: MOD:00998 ! iodinated tyrosine + +[Term] +id: MOD:01229 +name: L-iodohistidine +def: "A protein modification that effectively converts an L-histidine residue to an L-iodohistidine." [PubMed:15627961, PubMed:2026710, UniMod:129#H] +synonym: "I1His" EXACT PSI-MOD-label [] +synonym: "Iodination" RELATED UniMod-description [] +synonym: "Iodo" RELATED PSI-MS-label [] +xref: DiffAvg: "125.90" +xref: DiffFormula: "C 0 H -1 I 1 N 0 O 0" +xref: DiffMono: "125.896648" +xref: Formula: "C 6 H 6 I 1 N 3 O 1" +xref: MassAvg: "263.04" +xref: MassMono: "262.955560" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00500 ! monoiodinated residue +is_a: MOD:01049 ! halogenated histidine + +[Term] +id: MOD:01230 +name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form - site K +def: "modification from UniMod Isotopic label -" [PubMed:15602776, UniMod:365#K] +synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form" RELATED UniMod-description [] +synonym: "ICPL" RELATED PSI-MS-label [] +xref: DiffAvg: "105.02" +xref: DiffFormula: "(12)C 6 H 3 N 1 O 1" +xref: DiffMono: "105.021464" +xref: Formula: "(12)C 12 H 15 N 3 O 2" +xref: MassAvg: "233.12" +xref: MassMono: "233.116427" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00790 ! Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form + +[Term] +id: MOD:01231 +name: 3x(13)C labeled N6-propanoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:12442261, UniMod:59#K] +subset: PSI-MOD-slim +synonym: "Propionate labeling reagent heavy form (+3amu), N-term & K" RELATED UniMod-description [] +synonym: "Propionyl:13C(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "59.04" +xref: DiffFormula: "(13)C 3 H 4 O 1" +xref: DiffMono: "59.036279" +xref: Formula: "(12)C 6 (13)C 3 H 16 N 2 O 2" +xref: MassAvg: "187.13" +xref: MassMono: "187.131242" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01398 ! N6-propanoyl-L-lysine + +[Term] +id: MOD:01232 +name: 3x(12)C labeled N6-propanoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58#K] +subset: PSI-MOD-slim +synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] +synonym: "Propionyl" RELATED PSI-MS-label [] +xref: DiffAvg: "56.03" +xref: DiffFormula: "(12)C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "(12)C 9 H 16 N 2 O 2" +xref: MassAvg: "184.12" +xref: MassMono: "184.121178" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01398 ! N6-propanoyl-L-lysine + +[Term] +id: MOD:01233 +name: 3x(2)H labeled N6-acetyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:56#K] +subset: PSI-MOD-slim +synonym: "Acetate labeling reagent (N-term & K) (heavy form, +3amu)" RELATED UniMod-description [] +synonym: "Acetyl:2H(3)" RELATED PSI-MS-label [] +xref: DiffAvg: "45.03" +xref: DiffFormula: "C 2 (1)H -1 (2)H 3 O 1" +xref: DiffMono: "45.029395" +xref: Formula: "C 8 (1)H 11 (2)H 3 N 2 O 2" +xref: MassAvg: "173.12" +xref: MassMono: "173.124358" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00064 ! N6-acetyl-L-lysine +is_a: MOD:00449 ! acetate labeling reagent (N-term) (heavy form, +3amu) + +[Term] +id: MOD:01234 +name: (18)O monosubstituted L-serine +def: "modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, UniMod:258#S] +subset: PSI-MOD-slim +synonym: "Label:18O(1)" RELATED PSI-MS-label [] +synonym: "O18 Labeling" RELATED UniMod-description [] +xref: DiffAvg: "2.00" +xref: DiffFormula: "(16)O -1 (18)O 1" +xref: DiffMono: "2.004246" +xref: Formula: "C 3 H 5 N 1 (16)O 1 (18)O 1" +xref: MassAvg: "89.04" +xref: MassMono: "89.036275" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00581 ! (18)O monosubstituted residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01235 +name: (18)O monosubstituted L-threonine +def: "modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, PubMed:15549660, UniMod:258#T] +subset: PSI-MOD-slim +synonym: "Label:18O(1)" RELATED PSI-MS-label [] +synonym: "O18 Labeling" RELATED UniMod-description [] +xref: DiffAvg: "2.00" +xref: DiffFormula: "(16)O -1 (18)O 1" +xref: DiffMono: "2.004246" +xref: Formula: "C 4 H 7 N 1 (16)O 1 (18)O 1" +xref: MassAvg: "103.05" +xref: MassMono: "103.051925" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00581 ! (18)O monosubstituted residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01236 +name: (18)O monosubstituted L-tyrosine +def: "modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, PubMed:15549660, UniMod:258#Y] +subset: PSI-MOD-slim +synonym: "Label:18O(1)" RELATED PSI-MS-label [] +synonym: "O18 Labeling" RELATED UniMod-description [] +xref: DiffAvg: "2.00" +xref: DiffFormula: "(16)O -1 (18)O 1" +xref: DiffMono: "2.004246" +xref: Formula: "C 9 H 9 N 1 (16)O 1 (18)O 1" +xref: MassAvg: "165.07" +xref: MassMono: "165.067575" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00581 ! (18)O monosubstituted residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01237 +name: cysteine 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, PubMed:9629898, UniMod:53#C] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] +synonym: "HNE" RELATED PSI-MS-label [] +xref: DiffAvg: "156.22" +xref: DiffFormula: "C 9 H 16 O 2" +xref: DiffMono: "156.115030" +xref: Formula: "C 12 H 21 N 1 O 3 S 1" +xref: MassAvg: "259.36" +xref: MassMono: "259.124215" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00446 ! 4-hydroxynonenal adduct + +[Term] +id: MOD:01238 +name: lysine 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, PubMed:9629898, UniMod:53#K] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] +synonym: "HNE" RELATED PSI-MS-label [] +xref: DiffAvg: "156.22" +xref: DiffFormula: "C 9 H 16 O 2" +xref: DiffMono: "156.115030" +xref: Formula: "C 15 H 28 N 2 O 3" +xref: MassAvg: "284.40" +xref: MassMono: "284.209993" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00446 ! 4-hydroxynonenal adduct + +[Term] +id: MOD:01239 +name: histidine 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal." [PubMed:10717661, PubMed:11327326, PubMed:15133838, UniMod:53#H] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] +synonym: "HNE" RELATED PSI-MS-label [] +xref: DiffAvg: "156.22" +xref: DiffFormula: "C 9 H 16 O 2" +xref: DiffMono: "156.115030" +xref: Formula: "C 15 H 23 N 3 O 3" +xref: MassAvg: "293.37" +xref: MassMono: "293.173942" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00446 ! 4-hydroxynonenal adduct + +[Term] +id: MOD:01240 +name: ubiquitination signature tetrapeptidyl lysine +def: "A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin." [PubMed:10504701, UniMod:535] +synonym: "LeuArgGlyGly" RELATED PSI-MS-label [] +synonym: "Ubiquitination" RELATED UniMod-description [] +xref: DiffAvg: "383.45" +xref: DiffFormula: "C 16 H 29 N 7 O 4" +xref: DiffMono: "383.228102" +xref: Formula: "C 22 H 41 N 9 O 5" +xref: MassAvg: "511.63" +xref: MassMono: "511.323065" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01875 ! N6-acylated L-lysine +relationship: derives_from MOD:01148 ! ubiquitinylated lysine + +[Term] +id: MOD:01241 +name: 3x(2)H labeled L-aspartic acid 4-methyl ester +def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester." [OMSSA:19, PubMed:12185208, UniMod:298#D] +synonym: "deuterated methyl ester" RELATED UniMod-description [] +synonym: "Methyl:2H(3)" RELATED PSI-MS-label [] +synonym: "trideuteromethyld" EXACT OMSSA-label [] +xref: DiffAvg: "17.03" +xref: DiffFormula: "C 1 (1)H -1 (2)H 3" +xref: DiffMono: "17.034480" +xref: Formula: "C 5 (1)H 4 (2)H 3 N 1 O 3" +xref: MassAvg: "132.06" +xref: MassMono: "132.061423" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00617 ! 3x(2)H residue methyl ester +is_a: MOD:00904 ! modified L-aspartic acid residue +relationship: derives_from MOD:01181 ! L-aspartic acid 4-methyl ester + +[Term] +id: MOD:01242 +name: 3x(2)H labeled L-glutamic acid 5-methyl ester +def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester." [OMSSA:20, PubMed:1326520, UniMod:298#E] +synonym: "deuterated methyl ester" RELATED UniMod-description [] +synonym: "Methyl:2H(3)" RELATED PSI-MS-label [] +synonym: "trideuteromethyle" EXACT OMSSA-label [] +xref: DiffAvg: "17.03" +xref: DiffFormula: "C 1 (1)H -1 (2)H 3" +xref: DiffMono: "17.034480" +xref: Formula: "C 6 (1)H 6 (2)H 3 N 1 O 3" +xref: MassAvg: "146.08" +xref: MassMono: "146.077073" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00617 ! 3x(2)H residue methyl ester +is_a: MOD:00906 ! modified L-glutamic acid residue +relationship: derives_from MOD:00081 ! L-glutamic acid 5-methyl ester (Glu) + +[Term] +id: MOD:01243 +name: potassium carboxylate C-terminal residue +def: "A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt." [UniMod:530#C-term] +synonym: "Cation:K" RELATED PSI-MS-label [] +synonym: "Replacement of proton by potassium" RELATED UniMod-description [] +xref: DiffAvg: "38.09" +xref: DiffFormula: "H -1 K 1" +xref: DiffMono: "37.955882" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "C-term" +is_a: MOD:01072 ! monopotassium salt + +[Term] +id: MOD:01244 +name: potassium L-glutamate +def: "A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt." [UniMod:530#E] +synonym: "Cation:K" RELATED PSI-MS-label [] +synonym: "Replacement of proton by potassium" RELATED UniMod-description [] +xref: DiffAvg: "38.09" +xref: DiffFormula: "H -1 K 1" +xref: DiffMono: "37.955882" +xref: Formula: "C 5 H 6 K 1 N 1 O 3" +xref: MassAvg: "167.21" +xref: MassMono: "166.998475" +xref: Origin: "E" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01072 ! monopotassium salt + +[Term] +id: MOD:01245 +name: potassium L-aspartate +def: "A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt." [UniMod:530#D] +synonym: "Cation:K" RELATED PSI-MS-label [] +synonym: "Replacement of proton by potassium" RELATED UniMod-description [] +xref: DiffAvg: "38.09" +xref: DiffFormula: "H -1 K 1" +xref: DiffMono: "37.955882" +xref: Formula: "C 4 H 4 K 1 N 1 O 3" +xref: MassAvg: "153.18" +xref: MassMono: "152.982825" +xref: Origin: "D" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01072 ! monopotassium salt + +[Term] +id: MOD:01246 +name: fucosylated -site S +def: "OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812." [PubMed:11344537, PubMed:15189151, PubMed:3311742, PubMed:3578767, UniMod:295#S] +synonym: "dHex" RELATED PSI-MS-label [] +synonym: "Fucose" RELATED UniMod-description [] +xref: DiffAvg: "147.15" +xref: DiffFormula: "C 6 H 11 O 4" +xref: DiffMono: "147.065734" +xref: Formula: "C 9 H 16 N 1 O 6" +xref: MassAvg: "234.23" +xref: MassMono: "234.097762" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01247 +name: fucosylated -site T +def: "OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813." [PubMed:11344537, PubMed:11857757, PubMed:15189151, UniMod:295#T] +synonym: "dHex" RELATED PSI-MS-label [] +synonym: "Fucose" RELATED UniMod-description [] +xref: DiffAvg: "147.15" +xref: DiffFormula: "C 6 H 11 O 4" +xref: DiffMono: "147.065734" +xref: Formula: "C 10 H 18 N 1 O 6" +xref: MassAvg: "248.26" +xref: MassMono: "248.113412" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01248 +name: iodouridine monophosphate derivatized tyrosine +def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tyrosine residue to form an ether linkage." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292#Y] +comment: This has an ether linkage and not a phosphodiester linkage with UMP. +synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] +synonym: "IodoU-AMP" RELATED PSI-MS-label [] +xref: DiffAvg: "322.17" +xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" +xref: DiffMono: "322.020217" +xref: Formula: "C 18 H 20 N 3 O 11 P 1" +xref: MassAvg: "485.34" +xref: MassMono: "485.083545" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00611 ! iodouridine monophosphate derivatized residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01249 +name: iodouridine monophosphate derivatized tryptophan +def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tryptophan residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292#W] +comment: This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP. +synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] +synonym: "IodoU-AMP" RELATED PSI-MS-label [] +xref: DiffAvg: "322.17" +xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" +xref: DiffMono: "322.020217" +xref: Formula: "C 20 H 21 N 4 O 10 P 1" +xref: MassAvg: "508.38" +xref: MassMono: "508.099530" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00611 ! iodouridine monophosphate derivatized residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01250 +name: iodouridine monophosphate derivatized phenylalanine +def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-phenylalanine residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292#F] +comment: This has a carbon-carbon linkage and not a phosphodiester linkage with UMP. +synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] +synonym: "IodoU-AMP" RELATED PSI-MS-label [] +xref: DiffAvg: "322.17" +xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" +xref: DiffMono: "322.020217" +xref: Formula: "C 18 H 20 N 3 O 10 P 1" +xref: MassAvg: "469.34" +xref: MassMono: "469.088630" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00611 ! iodouridine monophosphate derivatized residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:01251 +name: N6-[3-(carboxamidomethylthio)propanoyl]lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine." [PubMed:15121203, UniMod:293#K] +synonym: "3-(carbamidomethylthio)propanoyl" RELATED UniMod-description [] +synonym: "CAMthiopropanoyl" RELATED PSI-MS-label [] +xref: DiffAvg: "145.18" +xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1" +xref: DiffMono: "145.019749" +xref: Formula: "C 11 H 19 N 3 O 3 S 1" +xref: MassAvg: "273.35" +xref: MassMono: "273.114712" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00612 ! 3-(carboxamidomethylthio)propanoylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01252 +name: 5-hydro-5-methylimidazol-4-one, methylglyoxal arginine adduct (+54 amu) +def: "OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933." [PubMed:9448752, UniMod:319#R] +synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] +synonym: "MDA adduct +54" RELATED UniMod-description [] +xref: DiffAvg: "54.05" +xref: DiffFormula: "C 3 H 2 O 1" +xref: DiffMono: "54.010565" +xref: Formula: "C 9 H 14 N 4 O 2" +xref: MassAvg: "210.24" +xref: MassMono: "210.111676" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01253 +name: malondialdehyde lysine adduct (+54 amu) +def: "modification from UniMod Chemical derivative - Malondialdehyde (MDA) adduct" [UniMod:319#K] +synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] +synonym: "MDA adduct +54" RELATED UniMod-description [] +xref: DiffAvg: "54.05" +xref: DiffFormula: "C 3 H 2 O 1" +xref: DiffMono: "54.010565" +xref: Formula: "C 9 H 14 N 2 O 2" +xref: MassAvg: "182.22" +xref: MassMono: "182.105528" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00630 ! C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01254 +name: 4x(2)H labeled dimethylated L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine." [OMSSA:189, PubMed:14670044, UniMod:199#K] +subset: PSI-MOD-slim +synonym: "DiMethyl-CHD2" RELATED UniMod-description [] +synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label [] +synonym: "mod189" EXACT OMSSA-label [] +xref: DiffAvg: "32.06" +xref: DiffFormula: "C 2 (2)H 4" +xref: DiffMono: "32.056407" +xref: Formula: "C 8 H 12 (2)H 4 N 2 O 1" +xref: MassAvg: "160.15" +xref: MassMono: "160.151370" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00552 ! 4x(2)H labeled dimethylated residue +is_a: MOD:00912 ! modified L-lysine residue +relationship: derives_from MOD:00084 ! N6,N6-dimethyl-L-lysine + +[Term] +id: MOD:01255 +name: S-(2-sulfanylethyl)cysteine (Ser) +def: "A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine." [PubMed:11507762, UniMod:200#S] +synonym: "EDT" RELATED UniMod-description [] +synonym: "Ethanedithiol" RELATED PSI-MS-label [] +synonym: "S-(2-mercaptoethyl)cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "76.18" +xref: DiffFormula: "C 2 H 4 O -1 S 2" +xref: DiffMono: "75.980528" +xref: Formula: "C 5 H 9 N 1 O 1 S 2" +xref: MassAvg: "163.25" +xref: MassMono: "163.012556" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00553 ! 1,2-ethanedithiol modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01256 +name: 3-methyl-S-(2-sulfanylethyl)cysteine (Thr) +def: "A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine." [PubMed:11507762, UniMod:200#T] +synonym: "beta-methyl-S-(2-mercaptoethyl)cysteine" EXACT PSI-MOD-alternate [] +synonym: "EDT" RELATED UniMod-description [] +synonym: "Ethanedithiol" RELATED PSI-MS-label [] +xref: DiffAvg: "76.18" +xref: DiffFormula: "C 2 H 4 O -1 S 2" +xref: DiffMono: "75.980528" +xref: Formula: "C 6 H 11 N 1 O 1 S 2" +xref: MassAvg: "177.28" +xref: MassMono: "177.028206" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00553 ! 1,2-ethanedithiol modified residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01257 +name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate - site K +def: "modification from UniMod Chemical derivative -" [PubMed:12716131, PubMed:14997490, UniMod:194#K] +synonym: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate" RELATED UniMod-description [] +synonym: "AccQTag" RELATED PSI-MS-label [] +xref: DiffAvg: "170.17" +xref: DiffFormula: "C 10 H 6 N 2 O 1" +xref: DiffMono: "170.048013" +xref: Formula: "C 16 H 18 N 4 O 2" +xref: MassAvg: "298.35" +xref: MassMono: "298.142976" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00547 ! 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate + +[Term] +id: MOD:01258 +name: N-methylmaleimide - site C +def: "modification from UniMod Chemical derivative -" [PubMed:9448752, UniMod:314#C] +synonym: "Nmethylmaleimide" RELATED PSI-MS-label [] +synonym: "Nmethylmaleimide" RELATED UniMod-description [] +xref: DiffAvg: "111.10" +xref: DiffFormula: "C 5 H 5 N 1 O 2" +xref: DiffMono: "111.032028" +xref: Formula: "C 8 H 10 N 2 O 3 S 1" +xref: MassAvg: "214.24" +xref: MassMono: "214.041213" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00625 ! N-methylmaleimide derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01259 +name: N-methylmaleimide - site K +def: "modification from UniMod Chemical derivative -" [PubMed:9448752, UniMod:314#K] +synonym: "Nmethylmaleimide" RELATED PSI-MS-label [] +synonym: "Nmethylmaleimide" RELATED UniMod-description [] +xref: DiffAvg: "111.10" +xref: DiffFormula: "C 5 H 5 N 1 O 2" +xref: DiffMono: "111.032028" +xref: Formula: "C 11 H 17 N 3 O 3" +xref: MassAvg: "239.27" +xref: MassMono: "239.126991" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00625 ! N-methylmaleimide derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01260 +name: nucleophilic addtion to cytopiloyne - site Y +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#Y] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "C 28 H 31 N 1 O 9" +xref: MassAvg: "525.55" +xref: MassMono: "525.199882" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01261 +name: nucleophilic addtion to cytopiloyne - site S +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#C] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "C 22 H 27 N 1 O 9" +xref: MassAvg: "449.46" +xref: MassMono: "449.168581" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01262 +name: nucleophilic addtion to cytopiloyne - site R +def: "modification from UniMod Chemical derivative -" [PubMed:12590383, PubMed:15549660, UniMod:270#R] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "C 25 H 34 N 4 O 8" +xref: MassAvg: "518.57" +xref: MassMono: "518.237664" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:01263 +name: nucleophilic addtion to cytopiloyne - site K +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#K] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "C 25 H 34 N 2 O 8" +xref: MassAvg: "490.55" +xref: MassMono: "490.231516" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01264 +name: nucleophilic addtion to cytopiloyne - site C +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#C] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "C 22 H 27 N 1 O 8 S 1" +xref: MassAvg: "465.52" +xref: MassMono: "465.145738" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01265 +name: nucleophilic addtion to cytopiloyne - site P +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#P] +synonym: "Cytopiloyne" RELATED PSI-MS-label [] +synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] +xref: DiffAvg: "362.38" +xref: DiffFormula: "C 19 H 22 O 7" +xref: DiffMono: "362.136553" +xref: Formula: "C 24 H 29 N 1 O 8" +xref: MassAvg: "459.50" +xref: MassMono: "459.189317" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:01266 +name: nucleophilic addition to cytopiloyne+H2O - site C +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#C] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "C 22 H 29 N 1 O 9 S 1" +xref: MassAvg: "483.53" +xref: MassMono: "483.156303" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01267 +name: nucleophilic addition to cytopiloyne+H2O - site K +def: "modification from UniMod Chemical derivative -" [PubMed:11746907, PubMed:15549660, UniMod:271#K] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "C 25 H 36 N 2 O 9" +xref: MassAvg: "508.57" +xref: MassMono: "508.242081" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01268 +name: nucleophilic addition to cytopiloyne+H2O - site T +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#T] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "C 23 H 31 N 1 O 10" +xref: MassAvg: "481.50" +xref: MassMono: "481.194796" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01269 +name: nucleophilic addition to cytopiloyne+H2O - site R +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#R] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "C 25 H 36 N 4 O 9" +xref: MassAvg: "536.58" +xref: MassMono: "536.248229" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:01270 +name: nucleophilic addition to cytopiloyne+H2O - site S +def: "modification from UniMod Chemical derivative -" [PubMed:14670044, PubMed:15549660, UniMod:271#S] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "C 22 H 29 N 1 O 10" +xref: MassAvg: "467.47" +xref: MassMono: "467.179146" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01271 +name: nucleophilic addition to cytopiloyne+H2O - site Y +def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#Y] +synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] +synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] +xref: DiffAvg: "380.39" +xref: DiffFormula: "C 19 H 24 O 8" +xref: DiffMono: "380.147118" +xref: Formula: "C 28 H 33 N 1 O 10" +xref: MassAvg: "543.57" +xref: MassMono: "543.210446" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01272 +name: iminobiotinylation - site K +def: "modification from UniMod Chemical derivative -" [PubMed:9750125, UniMod:89#K] +synonym: "Iminobiotin" RELATED PSI-MS-label [] +synonym: "Iminobiotinylation" RELATED UniMod-description [] +xref: DiffAvg: "225.31" +xref: DiffFormula: "C 10 H 15 N 3 O 1 S 1" +xref: DiffMono: "225.093583" +xref: Formula: "C 16 H 27 N 5 O 2 S 1" +xref: MassAvg: "353.49" +xref: MassMono: "353.188546" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00467 ! iminobiotinyl modified residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01273 +name: O-[4-(2-aminoethyl)benzenesulfonyl] serine +def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue." [PubMed:15283597, PubMed:8597590, UniMod:276#S] +synonym: "AEBS" RELATED PSI-MS-label [] +synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] +xref: DiffAvg: "183.23" +xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" +xref: DiffMono: "183.035400" +xref: Formula: "C 11 H 14 N 2 O 4 S 1" +xref: MassAvg: "270.30" +xref: MassMono: "270.067428" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01274 +name: N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine +def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue." [PubMed:8597590, UniMod:276#H] +synonym: "AEBS" RELATED PSI-MS-label [] +synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] +xref: DiffAvg: "183.23" +xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" +xref: DiffMono: "183.035400" +xref: Formula: "C 14 H 16 N 4 O 3 S 1" +xref: MassAvg: "320.37" +xref: MassMono: "320.094311" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01275 +name: N6-[4-(2-aminoethyl)benzenesulfonyl]lysine +def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue." [PubMed:8597590, UniMod:276#K] +synonym: "AEBS" RELATED PSI-MS-label [] +synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] +xref: DiffAvg: "183.23" +xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" +xref: DiffMono: "183.035400" +xref: Formula: "C 14 H 21 N 3 O 3 S 1" +xref: MassAvg: "311.40" +xref: MassMono: "311.130363" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01276 +name: O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine +def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue." [PubMed:10906242, PubMed:8597590, UniMod:276#Y] +synonym: "AEBS" RELATED PSI-MS-label [] +synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] +xref: DiffAvg: "183.23" +xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" +xref: DiffMono: "183.035400" +xref: Formula: "C 17 H 18 N 2 O 4 S 1" +xref: MassAvg: "346.40" +xref: MassMono: "346.098728" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01277 +name: crotonaldehyde - site C +def: "modification from UniMod Other -" [PubMed:11283024, UniMod:253#C] +synonym: "Crotonaldehyde" RELATED PSI-MS-label [] +synonym: "Crotonaldehyde" RELATED UniMod-description [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "C 7 H 11 N 1 O 2 S 1" +xref: MassAvg: "173.23" +xref: MassMono: "173.051050" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00576 ! crotonaldehyde +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01278 +name: crotonaldehyde - site K +def: "modification from UniMod Other -" [PubMed:11283024, UniMod:253#K] +synonym: "Crotonaldehyde" RELATED PSI-MS-label [] +synonym: "Crotonaldehyde" RELATED UniMod-description [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "C 10 H 18 N 2 O 2" +xref: MassAvg: "198.27" +xref: MassMono: "198.136828" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00576 ! crotonaldehyde +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01279 +name: crotonaldehyde - site H +def: "modification from UniMod Other -" [PubMed:11283024, PubMed:1443554, UniMod:253#H] +synonym: "Crotonaldehyde" RELATED PSI-MS-label [] +synonym: "Crotonaldehyde" RELATED UniMod-description [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "C 10 H 13 N 3 O 2" +xref: MassAvg: "207.23" +xref: MassMono: "207.100777" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00576 ! crotonaldehyde +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01280 +name: EDT-iodo-PEO-biotin - site T +def: "modification from UniMod Chemical derivative -" [PubMed:11857757, PubMed:12175151, UniMod:118#T] +synonym: "EDT-iodo-PEO-biotin" RELATED UniMod-description [] +synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label [] +xref: DiffAvg: "490.70" +xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3" +xref: DiffMono: "490.174219" +xref: Formula: "C 24 H 41 N 5 O 6 S 3" +xref: MassAvg: "591.80" +xref: MassMono: "591.221897" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00490 ! EDT-iodo-PEO-biotin +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01281 +name: EDT-iodo-PEO-biotin - site S +def: "modification from UniMod Chemical derivative -" [PubMed:16335955, UniMod:118#S] +synonym: "EDT-iodo-PEO-biotin" RELATED UniMod-description [] +synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label [] +xref: DiffAvg: "490.70" +xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3" +xref: DiffMono: "490.174219" +xref: Formula: "C 23 H 39 N 5 O 6 S 3" +xref: MassAvg: "577.77" +xref: MassMono: "577.206247" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00490 ! EDT-iodo-PEO-biotin +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01282 +name: acrolein addition +56 - site H +def: "modification from UniMod Other -" [PubMed:10825247, PubMed:15541752, UniMod:206#H] +synonym: "Acrolein addition +56" RELATED UniMod-description [] +synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "C 9 H 11 N 3 O 2" +xref: MassAvg: "193.21" +xref: MassMono: "193.085127" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00557 ! acrolein addition +56 +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01283 +name: acrolein addition +56 - site K +def: "modification from UniMod Other -" [PubMed:10825247, PubMed:15541752, UniMod:206#K] +synonym: "Acrolein addition +56" RELATED UniMod-description [] +synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "C 9 H 16 N 2 O 2" +xref: MassAvg: "184.24" +xref: MassMono: "184.121178" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00557 ! acrolein addition +56 +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01284 +name: acrolein addition +56 - site C +def: "modification from UniMod Other -" [PubMed:10825247, PubMed:15541752, PubMed:9254591, UniMod:206#C] +synonym: "Acrolein addition +56" RELATED UniMod-description [] +synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "C 6 H 9 N 1 O 2 S 1" +xref: MassAvg: "159.20" +xref: MassMono: "159.035400" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00557 ! acrolein addition +56 +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01285 +name: 6x(13)C,1x(15)N labeled L-leucine +def: "A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:695#L] +synonym: "13C(6) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "7.02" +xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1" +xref: DiffMono: "7.017164" +xref: Formula: "(13)C 6 H 11 (15)N 1 O 1" +xref: MassAvg: "120.10" +xref: MassMono: "120.101228" +xref: Origin: "L" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00911 ! modified L-leucine residue +is_a: MOD:01370 ! 6x(13)C,1x(15)N labeled residue + +[Term] +id: MOD:01286 +name: 6x(13)C,1x(15)N labeled L-isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:695#I] +synonym: "13C(6) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "7.02" +xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1" +xref: DiffMono: "7.017164" +xref: Formula: "(13)C 6 H 11 (15)N 1 O 1" +xref: MassAvg: "120.10" +xref: MassMono: "120.101228" +xref: Origin: "I" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:01370 ! 6x(13)C,1x(15)N labeled residue + +[Term] +id: MOD:01287 +name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form - site K +def: "modification from UniMod Isotopic label -" [PubMed:11857757, PubMed:15602776, UniMod:364#K] +synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form" RELATED UniMod-description [] +synonym: "ICPL:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "111.04" +xref: DiffFormula: "(13)C 6 H 3 N 1 O 1" +xref: DiffMono: "111.041593" +xref: Formula: "C 6 (13)C 6 H 15 N 3 O 2" +xref: MassAvg: "239.14" +xref: MassMono: "239.136556" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00789 ! Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01288 +name: acetaldehyde +28 - site H +def: "modification from UniMod Other -" [UniMod:255#H] +synonym: "Acetaldehyde +28" RELATED UniMod-description [] +synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 11 N 3 O 1" +xref: MassAvg: "165.20" +xref: MassMono: "165.090212" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00578 ! acetaldehyde +28 +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01289 +name: acetaldehyde +28 - site K +def: "modification from UniMod Other -" [UniMod:255#K] +synonym: "Acetaldehyde +28" RELATED UniMod-description [] +synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 2 O 1" +xref: MassAvg: "156.23" +xref: MassMono: "156.126263" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00578 ! acetaldehyde +28 +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01290 +name: dihydroxylated residue - site F +def: "OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465." [PubMed:11857757, PubMed:12175151, PubMed:12686488, PubMed:9252331, UniMod:425] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 9 H 9 N 1 O 3" +xref: MassAvg: "179.17" +xref: MassMono: "179.058243" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01291 +name: dihydroxylated residue - site W +def: "OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464." [PubMed:12643539, PubMed:12686488, PubMed:6273432, PubMed:9252331, UniMod:425] +synonym: "dihydroxy" RELATED UniMod-description [] +synonym: "Dioxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 11 H 10 N 2 O 3" +xref: MassAvg: "218.21" +xref: MassMono: "218.069142" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01292 +name: dimethylation of proline residue +def: "OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075." [UniMod:529] +synonym: "Delta:H(5)C(2)" RELATED PSI-MS-label [] +synonym: "Dimethylation of proline residue" RELATED UniMod-description [] +xref: DiffAvg: "29.06" +xref: DiffFormula: "C 2 H 5" +xref: DiffMono: "29.039125" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01293 +name: 1x(18)O labeled deamidated L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O." [OMSSA:139, PubMed:8382902, UniMod:366#N] +subset: PSI-MOD-slim +synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] +synonym: "Deamidation in presence of O18" RELATED UniMod-description [] +synonym: "oxy18" EXACT OMSSA-label [] +xref: DiffAvg: "2.99" +xref: DiffFormula: "H -1 N -1 (18)O 1" +xref: DiffMono: "2.988262" +xref: Formula: "C 4 H 5 N 1 (16)O 2 (18)O 1" +xref: MassAvg: "117.03" +xref: MassMono: "117.031189" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00852 ! 1x(18)O labeled deamidated residue +relationship: derives_from MOD:00684 ! deamidated L-asparagine + +[Term] +id: MOD:01294 +name: deamidation in presence of O18 -site Q +def: "OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791." [PubMed:8382902] +synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] +synonym: "Deamidation in presence of O18" RELATED UniMod-description [] +xref: DiffAvg: "2.99" +xref: DiffFormula: "H -1 N -1 (18)O 1" +xref: DiffMono: "2.988262" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Q" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01295 +name: monosodium L-aspartate +def: "A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate." [PubMed:12216740, UniMod:30#D] +subset: PSI-MOD-slim +synonym: "Cation:Na" RELATED PSI-MS-label [] +synonym: "Na1Asp" EXACT PSI-MOD-label [] +synonym: "Sodium adduct" RELATED UniMod-description [] +xref: DiffAvg: "21.98" +xref: DiffFormula: "H -1 Na 1" +xref: DiffMono: "21.981944" +xref: Formula: "C 4 H 4 N 1 Na 1 O 3" +xref: MassAvg: "137.07" +xref: MassMono: "137.008887" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00423 ! monosodium salt +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01296 +name: monosodium L-glutamate +def: "A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate." [PubMed:12216740, UniMod:30#E] +subset: PSI-MOD-slim +synonym: "Cation:Na" RELATED PSI-MS-label [] +synonym: "MSG" EXACT PSI-MOD-alternate [] +synonym: "Na1Glu" EXACT PSI-MOD-label [] +synonym: "Sodium adduct" RELATED UniMod-description [] +xref: DiffAvg: "21.98" +xref: DiffFormula: "H -1 Na 1" +xref: DiffMono: "21.981944" +xref: Formula: "C 5 H 6 N 1 Na 1 O 3" +xref: MassAvg: "151.10" +xref: MassMono: "151.024537" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00423 ! monosodium salt +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01297 +name: 5x(13)C labeled L-proline +def: "A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline." [PubMed:12716131, UniMod:772#P] +comment: In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC. +synonym: "13C(5) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "5.02" +xref: DiffFormula: "(12)C -5 (13)C 5" +xref: DiffMono: "5.016774" +xref: Formula: "(13)C 5 H 7 N 1 O 1" +xref: MassAvg: "102.07" +xref: MassMono: "102.069538" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01832 ! 5x(13)C-labeled residue + +[Term] +id: MOD:01298 +name: reduced cysteine 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:15133838, UniMod:335#C] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] +synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] +xref: DiffAvg: "158.24" +xref: DiffFormula: "C 9 H 18 O 2" +xref: DiffMono: "158.130680" +xref: Formula: "C 12 H 23 N 1 O 3 S 1" +xref: MassAvg: "261.38" +xref: MassMono: "261.139865" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct +is_a: MOD:00905 ! modified L-cysteine residue +relationship: derives_from MOD:01237 ! cysteine 4-hydroxynonenal adduct + +[Term] +id: MOD:01299 +name: reduced lysine 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:12148805, PubMed:15133838, UniMod:335#K] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] +synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] +xref: DiffAvg: "158.24" +xref: DiffFormula: "C 9 H 18 O 2" +xref: DiffMono: "158.130680" +xref: Formula: "C 15 H 30 N 2 O 3" +xref: MassAvg: "286.42" +xref: MassMono: "286.225643" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct +is_a: MOD:00912 ! modified L-lysine residue +relationship: derives_from MOD:01238 ! lysine 4-hydroxynonenal adduct + +[Term] +id: MOD:01300 +name: reduced histidine 4-hydroxynonenal adduct +def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:12148805, PubMed:15133838, UniMod:335#H] +comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. +synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] +synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] +xref: DiffAvg: "158.24" +xref: DiffFormula: "C 9 H 18 O 2" +xref: DiffMono: "158.130680" +xref: Formula: "C 15 H 25 N 3 O 3" +xref: MassAvg: "295.38" +xref: MassMono: "295.189592" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct +is_a: MOD:00909 ! modified L-histidine residue +relationship: derives_from MOD:01239 ! histidine 4-hydroxynonenal adduct + +[Term] +id: MOD:01301 +name: methylamine Michael addition derivatized threonine +def: "A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid." [PubMed:11743741, UniMod:337#T] +comment: In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid. +synonym: "Methylamine" RELATED PSI-MS-label [] +synonym: "Michael addition with methylamine" RELATED UniMod-description [] +xref: DiffAvg: "13.04" +xref: DiffFormula: "C 1 H 3 N 1 O -1" +xref: DiffMono: "13.031634" +xref: Formula: "C 5 H 10 N 2 O 1" +xref: MassAvg: "114.15" +xref: MassMono: "114.079313" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00643 ! methylamine Michael addition derivatized residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01302 +name: methylamine Michael addition derivatized serine +def: "A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid." [PubMed:11743741, UniMod:337#S] +comment: In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid. +synonym: "Methylamine" RELATED PSI-MS-label [] +synonym: "Michael addition with methylamine" RELATED UniMod-description [] +xref: DiffAvg: "13.04" +xref: DiffFormula: "C 1 H 3 N 1 O -1" +xref: DiffMono: "13.031634" +xref: Formula: "C 4 H 8 N 2 O 1" +xref: MassAvg: "100.12" +xref: MassMono: "100.063663" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00643 ! methylamine Michael addition derivatized residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01303 +name: N4-hexosaminylated asparagine +def: "A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine." [PubMed:11467524, UniMod:454#N] +comment: The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG]. +synonym: "HexN" RELATED PSI-MS-label [] +synonym: "Hexosamine" RELATED UniMod-description [] +xref: DiffAvg: "161.16" +xref: DiffFormula: "C 6 H 11 N 1 O 4" +xref: DiffMono: "161.068808" +xref: Formula: "C 10 H 17 N 3 O 6" +xref: MassAvg: "275.26" +xref: MassMono: "275.111735" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00160 ! N4-glycosyl-L-asparagine +is_a: MOD:00876 ! hexosaminylated residue + +[Term] +id: MOD:01304 +name: N6-hexosaminylated lysine +def: "A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group." [UniMod:454#K] +synonym: "HexN" RELATED PSI-MS-label [] +synonym: "Hexosamine" RELATED UniMod-description [] +xref: DiffAvg: "161.16" +xref: DiffFormula: "C 6 H 11 N 1 O 4" +xref: DiffMono: "161.068808" +xref: Formula: "C 12 H 23 N 3 O 5" +xref: MassAvg: "289.33" +xref: MassMono: "289.163771" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00876 ! hexosaminylated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01305 +name: N1'-hexosaminylated tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan." [UniMod:454#W] +comment: The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG]. +synonym: "HexN" RELATED PSI-MS-label [] +synonym: "Hexosamine" RELATED UniMod-description [] +xref: DiffAvg: "161.16" +xref: DiffFormula: "C 6 H 11 N 1 O 4" +xref: DiffMono: "161.068808" +xref: Formula: "C 17 H 21 N 3 O 5" +xref: MassAvg: "347.37" +xref: MassMono: "347.148121" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00876 ! hexosaminylated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01306 +name: O-hexosaminylated threonine +def: "A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine." [UniMod:454#T] +comment: The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG]. +synonym: "HexN" RELATED PSI-MS-label [] +synonym: "Hexosamine" RELATED UniMod-description [] +xref: DiffAvg: "161.16" +xref: DiffFormula: "C 6 H 11 N 1 O 4" +xref: DiffMono: "161.068808" +xref: Formula: "C 10 H 18 N 2 O 6" +xref: MassAvg: "262.26" +xref: MassMono: "262.116486" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00005 ! O-glycosyl-L-threonine +is_a: MOD:00876 ! hexosaminylated residue + +[Term] +id: MOD:01307 +name: thiophosphate labeled with biotin-HPDP -site S +def: "modification from UniMod Chemical derivative -" [UniMod:332#S] +synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] +synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] +xref: DiffAvg: "525.66" +xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" +xref: DiffMono: "525.142895" +xref: Formula: "C 22 H 39 N 5 O 7 P 1 S 3" +xref: MassAvg: "612.74" +xref: MassMono: "612.174923" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01308 +name: thiophosphate labeled with biotin-HPDP -site T +def: "modification from UniMod Chemical derivative -" [UniMod:332#T] +synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] +synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] +xref: DiffAvg: "525.66" +xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" +xref: DiffMono: "525.142895" +xref: Formula: "C 23 H 41 N 5 O 7 P 1 S 3" +xref: MassAvg: "626.76" +xref: MassMono: "626.190573" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01309 +name: thiophosphate labeled with biotin-HPDP - site Y +def: "modification from UniMod Chemical derivative - " [UniMod:332#Y] +synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] +synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] +xref: DiffAvg: "525.66" +xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" +xref: DiffMono: "525.142895" +xref: Formula: "C 28 H 43 N 5 O 7 P 1 S 3" +xref: MassAvg: "688.83" +xref: MassMono: "688.206223" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01310 +name: quaternary amine labeling reagent light form N6-L-lysine +def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group." [PubMed:11857757, UniMod:60#K] +synonym: "GIST-Quat" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent light form (N-term & K)" RELATED UniMod-description [] +xref: DiffAvg: "59.07" +xref: DiffFormula: "C 3 (1)H 9 N 1" +xref: DiffMono: "59.073499" +xref: Formula: "C 9 (1)H 21 N 3 O 1" +xref: MassAvg: "187.17" +xref: MassMono: "187.168462" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01311 +name: quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine +def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group." [PubMed:11698400, PubMed:11857757, PubMed:11914093, UniMod:61#K] +synonym: "GIST-Quat:2H(3)" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent heavy (+3amu) form, N-term & K" RELATED UniMod-description [] +xref: DiffAvg: "62.09" +xref: DiffFormula: "C 3 (1)H 6 (2)H 3 N 1" +xref: DiffMono: "62.092330" +xref: Formula: "C 9 (1)H 18 (2)H 3 N 3 O 1" +xref: MassAvg: "190.19" +xref: MassMono: "190.187293" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01312 +name: quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine +def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group." [PubMed:11857757, UniMod:62#K] +comment: Apparently incorrect parent [JSG]. +synonym: "GIST-Quat:2H(6)" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent heavy form (+6amu), N-term & K" RELATED UniMod-description [] +xref: DiffAvg: "65.11" +xref: DiffFormula: "C 3 (1)H 3 (2)H 6 N 1" +xref: DiffMono: "65.111160" +xref: Formula: "C 9 (1)H 15 (2)H 6 N 3 O 1" +xref: MassAvg: "193.21" +xref: MassMono: "193.206123" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01313 +name: quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine +def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group." [PubMed:11857757, UniMod:63#K] +synonym: "GIST-Quat:2H(9)" RELATED PSI-MS-label [] +synonym: "Quaternary amine labeling reagent heavy form (+9amu), N-term & K" RELATED UniMod-description [] +xref: DiffAvg: "68.13" +xref: DiffFormula: "C 3 (2)H 9 N 1" +xref: DiffMono: "68.129990" +xref: Formula: "C 9 (1)H 12 (2)H 9 N 3 O 1" +xref: MassAvg: "196.22" +xref: MassMono: "196.224953" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01314 +name: 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine." [PubMed:11857757, PubMed:12175151, PubMed:12716131, UniMod:64#K] +synonym: "Succinic anhydride labeling reagent light form (K)" RELATED UniMod-description [] +synonym: "Succinyl" RELATED PSI-MS-label [] +xref: DiffAvg: "100.02" +xref: DiffFormula: "(12)C 4 (1)H 4 O 3" +xref: DiffMono: "100.016044" +xref: Formula: "(12)C 10 H 16 N 2 O 4" +xref: MassAvg: "228.11" +xref: MassMono: "228.111007" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01819 ! N6-succinyl-L-lysine + +[Term] +id: MOD:01315 +name: 4x(2)H labeled N6-succinyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine." [PubMed:11344537, PubMed:11857757, PubMed:12175151, PubMed:15189151, UniMod:65#K] +synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K" RELATED UniMod-description [] +synonym: "Succinyl:2H(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "104.04" +xref: DiffFormula: "C 4 (2)H 4 O 3" +xref: DiffMono: "104.041151" +xref: Formula: "C 10 (1)H 12 (2)H 4 N 2 O 4" +xref: MassAvg: "232.14" +xref: MassMono: "232.136114" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01819 ! N6-succinyl-L-lysine + +[Term] +id: MOD:01316 +name: 4x(13)C labeled N6-succinyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine." [PubMed:11344537, PubMed:11857757, PubMed:12175151, PubMed:15189151, UniMod:66#K] +synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), K" RELATED UniMod-description [] +synonym: "Succinyl:13C(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "104.03" +xref: DiffFormula: "(13)C 4 H 4 O 3" +xref: DiffMono: "104.029463" +xref: Formula: "(12)C 6 (13)C 4 H 16 N 2 O 4" +xref: MassAvg: "232.12" +xref: MassMono: "232.124426" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01819 ! N6-succinyl-L-lysine + +[Term] +id: MOD:01317 +name: phosphorylation to amine thiol - site T +def: "modification from UniMod Chemical derivative -" [PubMed:12216740, UniMod:178#T] +synonym: "DAET" RELATED PSI-MS-label [] +synonym: "phosphorylation to amine thiol" RELATED UniMod-description [] +xref: DiffAvg: "87.18" +xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1" +xref: DiffMono: "87.050656" +xref: Formula: "C 8 H 16 N 2 O 1 S 1" +xref: MassAvg: "188.29" +xref: MassMono: "188.098334" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00535 ! phosphorylation to amine thiol +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01318 +name: phosphorylation to amine thiol - site S +def: "modification from UniMod Chemical derivative -" [PubMed:11510821, PubMed:12216740, PubMed:12422359, UniMod:178#S] +synonym: "DAET" RELATED PSI-MS-label [] +synonym: "phosphorylation to amine thiol" RELATED UniMod-description [] +xref: DiffAvg: "87.18" +xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1" +xref: DiffMono: "87.050656" +xref: Formula: "C 7 H 14 N 2 O 1 S 1" +xref: MassAvg: "174.26" +xref: MassMono: "174.082684" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00535 ! phosphorylation to amine thiol +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01319 +name: Michael addition of BHT quinone methide to histidine +def: "modification from UniMod Other" [PubMed:11510821, PubMed:12422359, PubMed:9448752, UniMod:176#H] +comment: Secondary adduct, much less common than cysteine. [UniMod] +synonym: "BHT" RELATED PSI-MS-label [] +synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] +xref: DiffAvg: "218.34" +xref: DiffFormula: "C 15 H 22 O 1" +xref: DiffMono: "218.167065" +xref: Formula: "C 21 H 29 N 3 O 2" +xref: MassAvg: "355.48" +xref: MassMono: "355.225977" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01320 +name: Michael addition of BHT quinone methide to lysine +def: "modification from UniMod Other" [PubMed:16078144, PubMed:9448752, UniMod:176#K] +comment: Secondary adduct, much less common than cysteine. [UniMod] +synonym: "BHT" RELATED PSI-MS-label [] +synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] +xref: DiffAvg: "218.34" +xref: DiffFormula: "C 15 H 22 O 1" +xref: DiffMono: "218.167065" +xref: Formula: "C 21 H 34 N 2 O 2" +xref: MassAvg: "346.51" +xref: MassMono: "346.262028" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01321 +name: Michael addition of BHT quinone methide to cysteine +def: "modification from UniMod Other" [PubMed:11510821, PubMed:12422359, PubMed:9448752, UniMod:176#C] +comment: Primary adduct formed. [UniMod] +synonym: "BHT" RELATED PSI-MS-label [] +synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] +xref: DiffAvg: "218.34" +xref: DiffFormula: "C 15 H 22 O 1" +xref: DiffMono: "218.167065" +xref: Formula: "C 18 H 27 N 1 O 2 S 1" +xref: MassAvg: "321.48" +xref: MassMono: "321.176250" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01322 +name: propionaldehyde +40 - site K +def: "modification from UniMod Other -" [PubMed:15549660, UniMod:256#K] +synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label [] +synonym: "Propionaldehyde +40" RELATED UniMod-description [] +xref: DiffAvg: "40.06" +xref: DiffFormula: "C 3 H 4" +xref: DiffMono: "40.031300" +xref: Formula: "C 9 H 16 N 2 O 1" +xref: MassAvg: "168.24" +xref: MassMono: "168.126263" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00579 ! propionaldehyde +40 +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01323 +name: propionaldehyde +40 - site H +def: "modification from UniMod Other -" [UniMod:256#H] +synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label [] +synonym: "Propionaldehyde +40" RELATED UniMod-description [] +xref: DiffAvg: "40.06" +xref: DiffFormula: "C 3 H 4" +xref: DiffMono: "40.031300" +xref: Formula: "C 9 H 11 N 3 O 1" +xref: MassAvg: "177.21" +xref: MassMono: "177.090212" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00579 ! propionaldehyde +40 +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01324 +name: acetaldehyde +26 - site H +def: "modification from UniMod Other -" [PubMed:7744761, UniMod:254#H] +synonym: "Acetaldehyde +26" RELATED UniMod-description [] +synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "26.04" +xref: DiffFormula: "C 2 H 2" +xref: DiffMono: "26.015650" +xref: Formula: "C 8 H 9 N 3 O 1" +xref: MassAvg: "163.18" +xref: MassMono: "163.074562" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00577 ! acetaldehyde +26 +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01325 +name: acetaldehyde +26 - site K +def: "modification from UniMod Other -" [PubMed:7744761, UniMod:254#K] +synonym: "Acetaldehyde +26" RELATED UniMod-description [] +synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "26.04" +xref: DiffFormula: "C 2 H 2" +xref: DiffMono: "26.015650" +xref: Formula: "C 8 H 14 N 2 O 1" +xref: MassAvg: "154.21" +xref: MassMono: "154.110613" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00577 ! acetaldehyde +26 +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01326 +name: 9x(13)C labeled L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine." [PubMed:11510821, PubMed:12422359, PubMed:12716131, UniMod:184#Y] +synonym: "13C(9) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(9)" RELATED PSI-MS-label [] +xref: DiffAvg: "9.03" +xref: DiffFormula: "(12)C -9 (13)C 9" +xref: DiffMono: "9.030194" +xref: Formula: "(13)C 9 H 9 N 1 O 2" +xref: MassAvg: "172.09" +xref: MassMono: "172.093522" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00540 ! 9x(13)C labeled residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01327 +name: 9x(13)C labeled L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine." [PubMed:12716131, UniMod:184#F] +synonym: "13C(9) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(9)" RELATED PSI-MS-label [] +xref: DiffAvg: "9.03" +xref: DiffFormula: "(12)C -9 (13)C 9" +xref: DiffMono: "9.030194" +xref: Formula: "(13)C 9 H 9 N 1 O 1" +xref: MassAvg: "156.10" +xref: MassMono: "156.098607" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00540 ! 9x(13)C labeled residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:01328 +name: iodoacetic acid - site W +def: "modification from UniMod Chemical derivative - hydroxylethanone" [PubMed:17525468, UniMod:6#W] +comment: There is no citation for this UniMod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG]. +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "C 13 H 12 N 2 O 3" +xref: MassAvg: "244.25" +xref: MassMono: "244.084792" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00399 ! iodoacetic acid derivatized residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01329 +name: iodoacetic acid - site C +def: "OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061" [DeltaMass:197] +comment: Modification from UniMod Chemical derivative, UniMod:6 site C +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01330 +name: iodoacetic acid -site K +def: "OBSOLETE because identical with MOD:01094. Remap to MOD:01094" [PubMed:18688235] +comment: a modification from UniMod:6 +synonym: "Carboxymethyl" RELATED PSI-MS-label [] +synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 O 2" +xref: DiffMono: "58.005479" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01331 +name: 6x(13)C labeled L-arginine +def: "A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine." [OMSSA:136, PubMed:12716131, UniMod:188#R] +subset: PSI-MOD-slim +synonym: "13C(6) Silac label" RELATED UniMod-description [] +synonym: "arg-13c6" EXACT OMSSA-label [] +synonym: "Label:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.02" +xref: DiffFormula: "(12)C -6 (13)C 6" +xref: DiffMono: "6.020129" +xref: Formula: "(13)C 6 H 12 N 4 O 1" +xref: MassAvg: "162.12" +xref: MassMono: "162.121240" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00544 ! 6x(13)C labeled residue + +[Term] +id: MOD:01332 +name: 6x(13)C labeled L-leucine +def: "A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine." [PubMed:12716131, UniMod:188#L] +subset: PSI-MOD-slim +synonym: "13C(6) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.02" +xref: DiffFormula: "(12)C -6 (13)C 6" +xref: DiffMono: "6.020129" +xref: Formula: "(13)C 6 H 11 N 1 O 1" +xref: MassAvg: "119.10" +xref: MassMono: "119.104193" +xref: Origin: "L" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00544 ! 6x(13)C labeled residue + +[Term] +id: MOD:01333 +name: 6x(13)C labeled L-isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine." [PubMed:12716131, PubMed:12766232, UniMod:188#I] +subset: PSI-MOD-slim +synonym: "13C(6) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.02" +xref: DiffFormula: "(12)C -6 (13)C 6" +xref: DiffMono: "6.020129" +xref: Formula: "(13)C 6 H 11 N 1 O 1" +xref: MassAvg: "119.10" +xref: MassMono: "119.104193" +xref: Origin: "I" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00544 ! 6x(13)C labeled residue + +[Term] +id: MOD:01334 +name: 6x(13)C labeled L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine." [OMSSA:138, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:12716131, UniMod:188#K] +subset: PSI-MOD-slim +synonym: "13C(6) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)" RELATED PSI-MS-label [] +synonym: "lys-13c6" EXACT OMSSA-label [] +xref: DiffAvg: "6.02" +xref: DiffFormula: "(12)C -6 (13)C 6" +xref: DiffMono: "6.020129" +xref: Formula: "(13)C 6 H 12 N 2 O 1" +xref: MassAvg: "134.12" +xref: MassMono: "134.115092" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00544 ! 6x(13)C labeled residue + +[Term] +id: MOD:01335 +name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized lysine +def: "modification from UniMod Chemical derivative -" [PubMed:11467524, PubMed:16526082, UniMod:464#K] +synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED UniMod-description [] +synonym: "SPITC:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "220.99" +xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2" +xref: DiffMono: "220.991214" +xref: Formula: "(12)C 7 (13)C 6 H 17 N 3 O 4 S 2" +xref: MassAvg: "349.09" +xref: MassMono: "349.086177" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00880 ! 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01336 +name: deamidation followed by a methylation -site Q +def: "OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657." [PubMed:18688235] +comment: Modification from UniMod Post-translational - UniMod:528. +synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] +synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] +xref: DiffAvg: "15.01" +xref: DiffFormula: "C 1 H 1 N -1 O 1" +xref: DiffMono: "14.999666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01337 +name: deamidated 4-methyl esterified asparagine +def: "A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester." [UniMod:528#N] +comment: The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG]. +synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] +synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] +xref: DiffAvg: "15.01" +xref: DiffFormula: "C 1 H 1 N -1 O 1" +xref: DiffMono: "14.999666" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "N" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01181 ! L-aspartic acid 4-methyl ester +is_a: MOD:01369 ! deamidated and methyl esterified residue + +[Term] +id: MOD:01338 +name: N6-ethyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine." [PubMed:9629898, UniMod:280#K] +comment: The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. +synonym: "Ethyl" RELATED PSI-MS-label [] +synonym: "Ethylation" RELATED UniMod-description [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 2 O 1" +xref: MassAvg: "156.23" +xref: MassMono: "156.126263" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01339 ! ethylated residue + +[Term] +id: MOD:01339 +name: ethylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an ethyl group." [PubMed:9629898, UniMod:280] +comment: From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. +synonym: "Ethyl" RELATED PSI-MS-label [] +synonym: "Ethylation" RELATED UniMod-description [] +synonym: "EtRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00001 ! alkylated residue + +[Term] +id: MOD:01340 +name: ESP-Tag heavy d10 - site K +def: "modification from UniMod Isotopic label -" [PubMed:11078590, PubMed:11085420, PubMed:11821862, UniMod:91#K] +synonym: "ESP-Tag heavy d10" RELATED UniMod-description [] +synonym: "ESP:2H(10)" RELATED PSI-MS-label [] +xref: DiffAvg: "348.24" +xref: DiffFormula: "C 16 (1)H 16 (2)H 10 N 4 O 2 S 1" +xref: DiffMono: "348.240415" +xref: Formula: "C 22 (1)H 28 (2)H 10 N 6 O 3 S 1" +xref: MassAvg: "476.34" +xref: MassMono: "476.335378" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00469 ! ESP-Tag heavy d10 +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01341 +name: ESP-Tag light d0 - site K +def: "modification from UniMod Isotopic label -" [UniMod:90#K] +synonym: "ESP" RELATED PSI-MS-label [] +synonym: "ESP-Tag light d0" RELATED UniMod-description [] +xref: DiffAvg: "338.47" +xref: DiffFormula: "C 16 H 26 N 4 O 2 S 1" +xref: DiffMono: "338.177647" +xref: Formula: "C 22 H 38 N 6 O 3 S 1" +xref: MassAvg: "466.64" +xref: MassMono: "466.272610" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00468 ! ESP-Tag light d0 +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01342 +name: selenium substitution for sulfur - site M +def: "OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530." [PubMed:12148805, UniMod:162] +synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] +synonym: "Selenium replaces sulphur" RELATED UniMod-description [] +xref: DiffAvg: "46.91" +xref: DiffFormula: "S -1 Se 1" +xref: DiffMono: "47.944450" +xref: Formula: "C 5 H 9 N 1 O 1 S 0 Se 1" +xref: MassAvg: "178.10" +xref: MassMono: "178.984935" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01343 +name: selenium substitution for sulfur - site C +def: "OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686." [PubMed:12148805, UniMod:162] +synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] +synonym: "Selenium replaces sulphur" RELATED UniMod-description [] +xref: DiffAvg: "46.91" +xref: DiffFormula: "S -1 Se 1" +xref: DiffMono: "47.944450" +xref: Formula: "C 3 H 5 N 1 O 1 S 0 Se 1" +xref: MassAvg: "150.05" +xref: MassMono: "150.953635" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01344 +name: dehydrogenated residue - site S +def: "OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835." [PubMed:9252331, PubMed:9276974, UniMod:401] +synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] +synonym: "Didehydro" RELATED PSI-MS-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "H -2" +xref: DiffMono: "-2.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01345 +name: 2-amino-3-oxobutanoic acid +def: "A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid." [OMSSA:23, PubMed:12716131, PubMed:9252331, UniMod:401#T] +comment: There is no citation for this modification in the UniMod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG]. +synonym: "2-amino-3-ketobutyric acid" EXACT PSI-MOD-alternate [] +synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] +synonym: "3-ketobutyrine" EXACT PSI-MOD-alternate [] +synonym: "Didehydro" RELATED PSI-MS-label [] +synonym: "twoamino3oxobutanoicacid" EXACT OMSSA-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "H -2" +xref: DiffMono: "-2.015650" +xref: Formula: "C 4 H 5 N 1 O 2" +xref: MassAvg: "99.09" +xref: MassMono: "99.032028" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01346 +name: N4-hexosylated asparagine +def: "A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine." [PubMed:11112526, PubMed:11567090, PubMed:15279557, PubMed:6540775, UniMod:41#N] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 10 H 16 N 2 O 7" +xref: MassAvg: "276.25" +xref: MassMono: "276.095751" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00160 ! N4-glycosyl-L-asparagine +is_a: MOD:00434 ! hexosylated residue + +[Term] +id: MOD:01347 +name: hexose glycated L-lysine +def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct." [DeltaMass:0, PubMed:15279557, UniMod:41#K] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 12 H 22 N 2 O 6" +xref: MassAvg: "290.32" +xref: MassMono: "290.147786" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00767 ! glycated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01348 +name: O-hexosylated threonine +def: "A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine." [PubMed:15279557, PubMed:8597590, UniMod:41#T] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +xref: DiffAvg: "162.14" +xref: DiffFormula: "C 6 H 10 O 5" +xref: DiffMono: "162.052823" +xref: Formula: "C 10 H 17 N 1 O 7" +xref: MassAvg: "263.25" +xref: MassMono: "263.100502" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00005 ! O-glycosyl-L-threonine +is_a: MOD:00434 ! hexosylated residue + +[Term] +id: MOD:01349 +name: hydrolyzed N-ethylmaleimide cysteine adduct +def: "modification from UniMod Chemical derivative -" [UniMod:320#C] +comment: Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. +synonym: "Nethylmaleimide+water" RELATED PSI-MS-label [] +synonym: "Nethylmaleimidehydrolysis" RELATED UniMod-description [] +xref: DiffAvg: "143.14" +xref: DiffFormula: "C 6 H 9 N 1 O 3" +xref: DiffMono: "143.058243" +xref: Formula: "C 9 H 14 N 2 O 4 S 1" +xref: MassAvg: "246.28" +xref: MassMono: "246.067428" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00631 ! hydrolyzed N-ethylmaleimide adduct +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01350 +name: hydrolyzed N-ethylmaleimide lysine adduct +def: "modification from UniMod Chemical derivative -" [UniMod:320#K] +comment: Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. +synonym: "Nethylmaleimide+water" RELATED PSI-MS-label [] +synonym: "Nethylmaleimidehydrolysis" RELATED UniMod-description [] +xref: DiffAvg: "143.14" +xref: DiffFormula: "C 6 H 9 N 1 O 3" +xref: DiffMono: "143.058243" +xref: Formula: "C 12 H 21 N 3 O 4" +xref: MassAvg: "271.32" +xref: MassMono: "271.153206" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00631 ! hydrolyzed N-ethylmaleimide adduct + +[Term] +id: MOD:01351 +name: nitrated L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan." [OMSSA:85, PubMed:8839040, PubMed:9252331, UniMod:354#W] +comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. +synonym: "Nitro" RELATED PSI-MS-label [] +synonym: "nitrow" EXACT OMSSA-label [] +synonym: "Oxidation to nitro" RELATED UniMod-description [] +xref: DiffAvg: "45.00" +xref: DiffFormula: "H -1 N 1 O 2" +xref: DiffMono: "44.985078" +xref: Formula: "C 11 H 9 N 3 O 3" +xref: MassAvg: "231.21" +xref: MassMono: "231.064391" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00461 ! nitrosylation +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01352 +name: nitrated L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine." [OMSSA:86, PubMed:14678012, PubMed:8839040, PubMed:9252331, UniMod:354#Y] +comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. +subset: PSI-MOD-slim +synonym: "Nitro" RELATED PSI-MS-label [] +synonym: "nitroy" EXACT OMSSA-label [] +synonym: "Oxidation to nitro" RELATED UniMod-description [] +xref: DiffAvg: "45.00" +xref: DiffFormula: "H -1 N 1 O 2" +xref: DiffMono: "44.985078" +xref: Formula: "C 9 H 8 N 2 O 4" +xref: MassAvg: "208.17" +xref: MassMono: "208.048407" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00461 ! nitrosylation +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01353 +name: amidination of lysines or N-terminal amines with methyl acetimidate - site K +def: "modification from UniMod Chemical derivative -" [PubMed:12643539, PubMed:15602776, PubMed:6273432, UniMod:141#K] +synonym: "amidination of lysines or N-terminal amines with methyl acetimidate" RELATED UniMod-description [] +synonym: "Amidine" RELATED PSI-MS-label [] +xref: DiffAvg: "41.05" +xref: DiffFormula: "C 2 H 3 N 1" +xref: DiffMono: "41.026549" +xref: Formula: "C 8 H 15 N 3 O 1" +xref: MassAvg: "169.23" +xref: MassMono: "169.121512" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00509 ! amidination of lysines or N-terminal amines with methyl acetimidate +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01354 +name: Hex1HexNAc1NeuAc1 N4-glycosylated asparagine +def: "A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [PubMed:11698400, UniMod:149#N] +synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] +xref: DiffAvg: "657.60" +xref: DiffFormula: "C 25 H 41 N 2 O 18" +xref: DiffMono: "657.235437" +xref: Formula: "C 29 H 47 N 4 O 20" +xref: MassAvg: "771.70" +xref: MassMono: "771.278365" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:01355 +name: Hex1HexNAc1NeuAc1O-glycosylated threonine +def: "A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [UniMod:149#T] +synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] +xref: DiffAvg: "657.60" +xref: DiffFormula: "C 25 H 41 N 2 O 18" +xref: DiffMono: "657.235437" +xref: Formula: "C 29 H 48 N 3 O 20" +xref: MassAvg: "758.70" +xref: MassMono: "758.283116" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01356 +name: Hex1HexNAc1NeuAc1 O-glycosylated serine +def: "A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [PubMed:7856876, UniMod:149#S] +synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] +synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] +xref: DiffAvg: "657.60" +xref: DiffFormula: "C 25 H 41 N 2 O 18" +xref: DiffMono: "657.235437" +xref: Formula: "C 28 H 46 N 3 O 20" +xref: MassAvg: "744.68" +xref: MassMono: "744.267466" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01357 +name: 2x(13)C,4x(2)H labeled dimethylated L-lysine +def: "A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine." [PubMed:12686488, PubMed:16335955, UniMod:510#K] +synonym: "DiMethyl-C13HD2" RELATED UniMod-description [] +synonym: "Dimethyl:2H(4)13C(2)" RELATED PSI-MS-label [] +xref: DiffAvg: "34.06" +xref: DiffFormula: "(13)C 2 (2)H 4" +xref: DiffMono: "34.063117" +xref: Formula: "(12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1" +xref: MassAvg: "162.16" +xref: MassMono: "162.158080" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:00927 ! 2x(13)C,4x(2)H labeled dimethylated residue +relationship: derives_from MOD:00084 ! N6,N6-dimethyl-L-lysine + +[Term] +id: MOD:01358 +name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site N-term +def: "modification from UniMod Isotopic label - Use when labelling post-digest" [PubMed:15602776, UniMod:687#N-term] +synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form" RELATED UniMod-description [] +synonym: "ICPL:2H(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "109.05" +xref: DiffFormula: "C 6 (1)H -1 (2)H 4 N 1 O 1" +xref: DiffMono: "109.046571" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01359 +name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site K +def: "modification from UniMod Isotopic label - Use when labelling post-digest" [PubMed:15602776, UniMod:687#K] +synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form" RELATED UniMod-description [] +synonym: "ICPL:2H(4)" RELATED PSI-MS-label [] +xref: DiffAvg: "109.05" +xref: DiffFormula: "C 6 (1)H -1 (2)H 4 N 1 O 1" +xref: DiffMono: "109.046571" +xref: Formula: "C 12 (1)H 11 (2)H 4 N 3 O 2" +xref: MassAvg: "237.14" +xref: MassMono: "237.141534" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01360 +name: 4-sulfophenyl isothiocyanate N6-derivatized lysine +def: "A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine." [PubMed:14689565, PubMed:14745769, PubMed:15549660, PubMed:16526082, UniMod:261#K] +synonym: "4-sulfophenyl isothiocyanate" RELATED UniMod-description [] +synonym: "N6-[(4-sulfophenyl)carbamothioyl]lysine" EXACT PSI-MOD-alternate [] +synonym: "SPITC" RELATED PSI-MS-label [] +xref: DiffAvg: "215.24" +xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" +xref: DiffMono: "214.971085" +xref: Formula: "C 13 H 17 N 3 O 4 S 2" +xref: MassAvg: "343.42" +xref: MassMono: "343.066048" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01361 +name: O-thiophospho-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine." [PubMed:11507762, PubMed:12110917, UniMod:260#T] +synonym: "Thiophospho" RELATED PSI-MS-label [] +synonym: "Thiophosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "96.04" +xref: DiffFormula: "H 1 O 2 P 1 S 1" +xref: DiffMono: "95.943487" +xref: Formula: "C 4 H 8 N 1 O 4 P 1 S 1" +xref: MassAvg: "197.14" +xref: MassMono: "196.991165" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00583 ! thiophosphorylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01362 +name: O-thiophospho-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine." [PubMed:11507762, PubMed:12110917, UniMod:260#S] +synonym: "Thiophospho" RELATED PSI-MS-label [] +synonym: "Thiophosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "96.04" +xref: DiffFormula: "H 1 O 2 P 1 S 1" +xref: DiffMono: "95.943487" +xref: Formula: "C 3 H 6 N 1 O 4 P 1 S 1" +xref: MassAvg: "183.12" +xref: MassMono: "182.975515" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00583 ! thiophosphorylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01363 +name: O4'-thiophospho-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine." [PubMed:12110917, PubMed:15549660, UniMod:260#Y] +synonym: "Thiophospho" RELATED PSI-MS-label [] +synonym: "Thiophosphorylation" RELATED UniMod-description [] +xref: DiffAvg: "96.04" +xref: DiffFormula: "H 1 O 2 P 1 S 1" +xref: DiffMono: "95.943487" +xref: Formula: "C 9 H 10 N 1 O 4 P 1 S 1" +xref: MassAvg: "259.22" +xref: MassMono: "259.006815" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00583 ! thiophosphorylated residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01364 +name: fluorescein-5-thiosemicarbazide - site S +def: "modification from UniMod Chemical derivative -" [PubMed:11467524, UniMod:478#S] +synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] +synonym: "FTC" RELATED PSI-MS-label [] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "C 24 H 20 N 4 O 7 S 1" +xref: MassAvg: "508.51" +xref: MassMono: "508.105270" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01365 +name: fluorescein-5-thiosemicarbazide - site C +def: "modification from UniMod Chemical derivative -" [UniMod:478#C] +synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] +synonym: "FTC" RELATED PSI-MS-label [] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "C 24 H 20 N 4 O 6 S 2" +xref: MassAvg: "524.57" +xref: MassMono: "524.082426" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01366 +name: fluorescein-5-thiosemicarbazide - site K +def: "modification from UniMod Chemical derivative -" [UniMod:478#K] +synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] +synonym: "FTC" RELATED PSI-MS-label [] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "C 27 H 27 N 5 O 6 S 1" +xref: MassAvg: "549.60" +xref: MassMono: "549.168205" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01367 +name: fluorescein-5-thiosemicarbazide - site P +def: "modification from UniMod Chemical derivative -" [UniMod:478#P] +synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] +synonym: "FTC" RELATED PSI-MS-label [] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "C 26 H 22 N 4 O 6 S 1" +xref: MassAvg: "518.54" +xref: MassMono: "518.126005" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:01368 +name: fluorescein-5-thiosemicarbazide - site R +def: "modification from UniMod Chemical derivative -" [PubMed:15525938, UniMod:478#R] +synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] +synonym: "FTC" RELATED PSI-MS-label [] +xref: DiffAvg: "421.43" +xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" +xref: DiffMono: "421.073242" +xref: Formula: "C 27 H 27 N 7 O 6 S 1" +xref: MassAvg: "577.62" +xref: MassMono: "577.174353" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:01369 +name: deamidated and methyl esterified residue +def: "A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group." [UniMod:528] +subset: PSI-MOD-slim +synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] +synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] +xref: DiffAvg: "15.01" +xref: DiffFormula: "C 1 H 1 N -1 O 1" +xref: DiffMono: "14.999666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00393 ! O-methylated residue +is_a: MOD:00400 ! deamidated residue + +[Term] +id: MOD:01370 +name: 6x(13)C,1x(15)N labeled residue +def: "A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:695] +synonym: "13C(6) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "7.02" +xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1" +xref: DiffMono: "7.017164" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00843 ! (15)N labeled residue + +[Term] +id: MOD:01371 +name: deamidation in presence of O18 +def: "OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851." [PubMed:8382902] +synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] +synonym: "Deamidation in presence of O18" RELATED UniMod-description [] +xref: DiffAvg: "2.99" +xref: DiffFormula: "H -1 N -1 (18)O 1" +xref: DiffMono: "2.988262" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01372 +name: (2S)-4-hydroxyleucine +def: "A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine." [PubMed:363352, PubMed:9164839, RESID:AA0442] +synonym: "(2S)-2-amino-4-hydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-4-hydroxyleucine" EXACT RESID-name [] +synonym: "gamma-hydroxyleucine" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 11 N 1 O 2" +xref: MassAvg: "129.16" +xref: MassMono: "129.078979" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01411 ! monohydroxylated leucine + +[Term] +id: MOD:01373 +name: (2S,4R)-5-hydroxyleucine +def: "A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine." [PubMed:16858410, PubMed:7690768, PubMed:9164839, RESID:AA0443] +synonym: "(2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,4R)-5-hydroxyleucine" EXACT RESID-name [] +synonym: "(4R)-5-hydroxyleucine" EXACT RESID-alternate [] +synonym: "delta-hydroxyleucine" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 11 N 1 O 2" +xref: MassAvg: "129.16" +xref: MassMono: "129.078979" +xref: Origin: "L" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01411 ! monohydroxylated leucine + +[Term] +id: MOD:01374 +name: (2S,4R)-5-oxoleucine +def: "A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine." [ChEBI:43739, PubMed:16858410, RESID:AA0444] +synonym: "(2S,4R)-2-amino-4-methyl-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,4R)-5-oxoleucine" EXACT RESID-name [] +synonym: "(4R)-5-oxo-L-leucine" EXACT RESID-alternate [] +xref: DiffAvg: "13.98" +xref: DiffFormula: "C 0 H -2 N 0 O 1" +xref: DiffMono: "13.979265" +xref: Formula: "C 6 H 9 N 1 O 2" +xref: MassAvg: "127.14" +xref: MassMono: "127.063329" +xref: Origin: "L" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00911 ! modified L-leucine residue + +[Term] +id: MOD:01375 +name: (2S,4R)-4,5-dihydroxyleucine +def: "A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine." [PubMed:6010785, PubMed:6893271, RESID:AA0445] +synonym: "(2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,4R)-4,5-dihydroxyleucine" EXACT RESID-name [] +synonym: "(4R)-4,5-dihydroxyleucine" EXACT RESID-alternate [] +synonym: "gamma,delta-dihydroxyleucine" EXACT RESID-alternate [] +synonym: "MOD_RES (4R)-4,5-dihydroxyleucine" EXACT UniProt-feature [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 11 N 1 O 3" +xref: MassAvg: "145.16" +xref: MassMono: "145.073893" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01412 ! dihydroxylated leucine + +[Term] +id: MOD:01376 +name: (2S,3S,4R)-3,4-dihydroxyisoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine." [PubMed:11320328, RESID:AA0447] +synonym: "(2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3S,4R)-3,4-dihydroxyisoleucine" EXACT RESID-name [] +synonym: "(3S,4R)-3,4-dihydroxyisoleucine" EXACT RESID-alternate [] +synonym: "beta,gamma-dihydroxyisoleucine" EXACT RESID-alternate [] +synonym: "MOD_RES (3S,4R)-3,4-dihydroxyisoleucine" EXACT UniProt-feature [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 11 N 1 O 3" +xref: MassAvg: "145.16" +xref: MassMono: "145.073893" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01416 ! dihydroxylated isoleucine + +[Term] +id: MOD:01377 +name: (2S,3R,4S)-4-hydroxyisoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine." [PubMed:363352, RESID:AA0448] +synonym: "(2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid" EXACT RESID-alternate [] +synonym: "(2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R,4S)-4-hydroxyisoleucine" EXACT RESID-name [] +synonym: "(3R,4S)-4-hydroxyisoleucine" EXACT RESID-alternate [] +synonym: "gamma-hydroxyisoleucine" EXACT RESID-alternate [] +synonym: "MOD_RES (3R,4S)-4-hydroxyisoleucine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 11 N 1 O 2" +xref: MassAvg: "129.16" +xref: MassMono: "129.078979" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01415 ! monohydroxylated isoleucine + +[Term] +id: MOD:01378 +name: (2S,3R,4R)-4,5-dihydroxyisoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine." [PubMed:11805306, PubMed:18552824, PubMed:363352, RESID:AA0449] +synonym: "(2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R,4R)-4,5-dihydroxyisoleucine" EXACT RESID-name [] +synonym: "(3R,4R)-4,5-dihydroxyisoleucine" EXACT RESID-alternate [] +synonym: "gamma,delta-dihydroxyisoleucine" EXACT RESID-alternate [] +synonym: "MOD_RES (3R,4R)-4,5-dihydroxyisoleucine" EXACT UniProt-feature [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 11 N 1 O 3" +xref: MassAvg: "145.16" +xref: MassMono: "145.073893" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01416 ! dihydroxylated isoleucine + +[Term] +id: MOD:01379 +name: 2'-methylsulfonyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan." [PubMed:6893271, RESID:AA0450] +synonym: "2'-methylsulfonyl-L-tryptophan" EXACT RESID-name [] +synonym: "2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole" EXACT RESID-systematic [] +synonym: "MOD_RES 2'-methylsulfonyltryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "78.09" +xref: DiffFormula: "C 1 H 2 N 0 O 2 S 1" +xref: DiffMono: "77.977550" +xref: Formula: "C 12 H 12 N 2 O 3 S 1" +xref: MassAvg: "264.30" +xref: MassMono: "264.056863" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01380 +name: 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide." [PubMed:11805306, PubMed:18552824, PubMed:363352, PubMed:4865716, RESID:AA0451] +comment: Cross-link 2. +synonym: "2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide" EXACT RESID-name [] +synonym: "2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole" EXACT RESID-systematic [] +synonym: "6'-hydroxy-S-oxo-tryptathionine" EXACT RESID-alternate [] +synonym: "CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys)" EXACT UniProt-feature [] +xref: DiffAvg: "29.98" +xref: DiffFormula: "C 0 H -2 N 0 O 2 S 0" +xref: DiffMono: "29.974179" +xref: Formula: "C 14 H 13 N 3 O 4 S 1" +xref: MassAvg: "319.33" +xref: MassMono: "319.062677" +xref: Origin: "C, W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01381 +name: O-palmitoleyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine." [OMSSA:186, PubMed:17141155, RESID:AA0455] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid" EXACT RESID-systematic [] +synonym: "L-serine cis-9-hexadecenoate ester" EXACT RESID-alternate [] +synonym: "LIPID O-palmitoleyl serine" EXACT UniProt-feature [] +synonym: "mod186" EXACT OMSSA-label [] +synonym: "O-palmitoleyl-L-serine" EXACT RESID-name [] +synonym: "O3-palmitoleyl-serine" EXACT RESID-alternate [] +xref: DiffAvg: "236.40" +xref: DiffFormula: "C 16 H 28 N 0 O 1" +xref: DiffMono: "236.214016" +xref: Formula: "C 19 H 33 N 1 O 3" +xref: MassAvg: "323.48" +xref: MassMono: "323.246044" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01768 ! O-palmitoleylated residue + +[Term] +id: MOD:01382 +name: N,N,N-trimethyl-L-methionine +def: "A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine." [PubMed:18611379, RESID:AA0456] +subset: PSI-MOD-slim +synonym: "(1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium" EXACT RESID-systematic [] +synonym: "(1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium" EXACT RESID-alternate [] +synonym: "2-trimethylammonio-4-(methylthio)butanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N,N,N-trimethylmethionine" EXACT UniProt-feature [] +synonym: "N,N,N-trimethyl-L-methionine" EXACT RESID-name [] +synonym: "N,N,N-trimethylmethionine cation" EXACT RESID-alternate [] +synonym: "N,N,N-trimethylmethioninium" EXACT RESID-alternate [] +synonym: "N2Me3+Met" EXACT PSI-MOD-label [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0" +xref: DiffMono: "43.054227" +xref: FormalCharge: "1+" +xref: Formula: "C 8 H 17 N 1 O 1 S 1" +xref: MassAvg: "175.29" +xref: MassMono: "175.102537" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01463 ! N-methylated methionine +is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue + +[Term] +id: MOD:01383 +name: L-cystine S-oxide +def: "A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide." [RESID:AA0457] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys)" EXACT UniProt-feature [] +synonym: "cystine sulfoxide" EXACT RESID-alternate [] +synonym: "L-cystine S-oxide" EXACT RESID-name [] +synonym: "S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate" EXACT RESID-alternate [] +synonym: "S-cysteinyl 3-(oxidosulfanyl)alanine" EXACT RESID-alternate [] +xref: DiffAvg: "13.98" +xref: DiffFormula: "C 0 H -2 N 0 O 1 S 0" +xref: DiffMono: "13.979265" +xref: Formula: "C 6 H 8 N 2 O 3 S 2" +xref: MassAvg: "220.26" +xref: MassMono: "219.997634" +xref: Origin: "C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00689 ! disulfide crosslinked residues + +[Term] +id: MOD:01384 +name: aminomalonic acid (Ser) +def: "A protein modification that effectively converts an L-serine residue to an aminomalonic acid." [PubMed:1621954, PubMed:5415959, PubMed:6366787, PubMed:7457858, RESID:AA0458] +synonym: "2-carboxyglycine" EXACT RESID-alternate [] +synonym: "Ama" EXACT RESID-alternate [] +synonym: "aminomalonic acid" EXACT RESID-name [] +synonym: "aminopropanedioic acid" EXACT RESID-systematic [] +synonym: "MOD_RES Aminomalonic acid (Ser)" EXACT UniProt-feature [] +xref: DiffAvg: "13.98" +xref: DiffFormula: "C 0 H -2 N 0 O 1 S 0" +xref: DiffMono: "13.979265" +xref: Formula: "C 3 H 3 N 1 O 3" +xref: MassAvg: "101.06" +xref: MassMono: "101.011293" +xref: Origin: "S" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01385 +name: 3-hydroxy-L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine." [ChEBI:16795, OMSSA:63, PubMed:10625477, PubMed:15651011, PubMed:16734421, PubMed:1880060, PubMed:7398618, PubMed:7844053, RESID:AA0462] +synonym: "(2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "3-hydoxyphenylalanine" EXACT RESID-alternate [] +synonym: "3-hydroxy-L-phenylalanine" EXACT RESID-name [] +synonym: "3-phenyl-L-serine" EXACT RESID-alternate [] +synonym: "3HyPhe" EXACT PSI-MOD-label [] +synonym: "beta-hydroxyphenylalanine" EXACT RESID-alternate [] +synonym: "beta-phenylserine" EXACT RESID-alternate [] +synonym: "hydroxylationf" EXACT OMSSA-label [] +synonym: "L-threo-3-phenylserine" EXACT RESID-alternate [] +synonym: "MOD_RES 3-hydroxyphenylalanine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 9 H 9 N 1 O 2" +xref: MassAvg: "163.18" +xref: MassMono: "163.063329" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00914 ! modified L-phenylalanine residue + +[Term] +id: MOD:01386 +name: 3-hydroxy-L-valine +def: "A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine." [PubMed:7328054, RESID:AA0463] +synonym: "(2S)-2-amino-3-hydroxy-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "3-hydroxy-L-valine" EXACT RESID-name [] +synonym: "3-hydroxyvaline" EXACT RESID-alternate [] +synonym: "3HyVal" EXACT PSI-MOD-label [] +synonym: "MOD_RES 3-hydroxyvaline" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 9 N 1 O 2" +xref: MassAvg: "115.13" +xref: MassMono: "115.063329" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00920 ! modified L-valine residue + +[Term] +id: MOD:01387 +name: O-methyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine." [PubMed:7328054, RESID:AA0464] +synonym: "(2S,3R)-2-amino-3-methoxybutanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES O-methylthreonine" EXACT UniProt-feature [] +synonym: "O-methyl threonine" EXACT RESID-alternate [] +synonym: "O-methyl-L-threonine" EXACT RESID-name [] +synonym: "OMeThr" EXACT PSI-MOD-label [] +synonym: "threonine methyl ether" EXACT RESID-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 5 H 9 N 1 O 2" +xref: MassAvg: "115.13" +xref: MassMono: "115.063329" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01803 ! O-methylated threonine + +[Term] +id: MOD:01388 +name: 1-amino-2-propanol +def: "A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol." [ChEBI:15675, PubMed:7328054, RESID:AA0465] +synonym: "(2R)-1-aminopropan-2-ol" EXACT RESID-systematic [] +synonym: "1-amino-2-hydroxypropane" EXACT RESID-alternate [] +synonym: "1-amino-2-propanol" EXACT RESID-name [] +synonym: "1-methyl-2-aminoethanol" EXACT RESID-alternate [] +synonym: "2-amino-1-methylethanol" EXACT RESID-alternate [] +synonym: "2-hydroxy-1-propylamine" EXACT RESID-alternate [] +synonym: "2-hydroxypropanamine" EXACT RESID-alternate [] +synonym: "2-hydroxypropylamine" EXACT RESID-alternate [] +synonym: "alpha-aminoisopropyl alcohol" EXACT RESID-alternate [] +synonym: "dCbxThr" EXACT PSI-MOD-label [] +synonym: "decarboxylated threonine" EXACT RESID-alternate [] +synonym: "isopropanolamine" EXACT RESID-alternate [] +synonym: "MOD_RES Decarboxylated threonine" EXACT UniProt-feature [] +synonym: "threamine" EXACT RESID-alternate [] +xref: DiffAvg: "-44.01" +xref: DiffFormula: "C -1 H 0 N 0 O -2" +xref: DiffMono: "-43.989829" +xref: Formula: "C 3 H 8 N 1 O 1" +xref: MassAvg: "74.10" +xref: MassMono: "74.060589" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:00960 ! decarboxylated residue + +[Term] +id: MOD:01389 +name: L-isoleucine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid." [PubMed:11320328, RESID:AA0466] +comment: Cross-link 2. +synonym: "2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys)" EXACT UniProt-feature [] +synonym: "L-isoleucine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 9 H 12 N 2 O 1 S 1" +xref: MassAvg: "196.27" +xref: MassMono: "196.067034" +xref: Origin: "C, I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01390 +name: L-valine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid." [PubMed:7328054, RESID:AA0467] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Val-Cys)" EXACT UniProt-feature [] +synonym: "L-valine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 8 H 10 N 2 O 1 S 1" +xref: MassAvg: "182.24" +xref: MassMono: "182.051384" +xref: Origin: "C, V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01391 +name: L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0468] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys)" EXACT UniProt-feature [] +synonym: "L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "24.02" +xref: DiffFormula: "C 2 H 0 N 0 O 0 S 0" +xref: DiffMono: "24.000000" +xref: Formula: "C 10 H 14 N 2 O 2 S 1" +xref: MassAvg: "226.29" +xref: MassMono: "226.077599" +xref: Origin: "C, V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01392 +name: L-asparagine 5-methylthiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0469] +comment: Cross-link 2. +synonym: "2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys)" EXACT UniProt-feature [] +synonym: "L-asparagine 5-methylthiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-6.00" +xref: DiffFormula: "C 1 H -2 N 0 O -1 S 0" +xref: DiffMono: "-6.010565" +xref: Formula: "C 8 H 9 N 3 O 2 S 1" +xref: MassAvg: "211.24" +xref: MassMono: "211.041548" +xref: Origin: "C, N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue +relationship: derives_from MOD:00656 ! C-methylated residue + +[Term] +id: MOD:01393 +name: L-cysteine pyridine-2,5-dicarboxylic acid +def: "A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0470] +comment: Cross-link 3. +synonym: "6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid" EXACT RESID-systematic [] +synonym: "L-cysteine pyridine-2,5-dicarboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-70.07" +xref: DiffFormula: "C 0 H -8 N -1 O -3 S 0" +xref: DiffMono: "-70.050418" +xref: Formula: "C 9 H 7 N 2 O 2 S 1" +xref: MassAvg: "207.23" +xref: MassMono: "207.022823" +xref: Origin: "C, S, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01425 ! pyridinyl ring crosslinked residues + +[Term] +id: MOD:01394 +name: L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid +def: "A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid." [PubMed:11320328, RESID:AA0471] +comment: Cross-link 3. +synonym: "(5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid" EXACT RESID-systematic [] +synonym: "L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid" EXACT RESID-name [] +synonym: "L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid" EXACT RESID-alternate [] +xref: DiffAvg: "-53.04" +xref: DiffFormula: "C 0 H -5 N 0 O -3 S 0" +xref: DiffMono: "-53.023869" +xref: Formula: "C 9 H 11 N 3 O 2 S 1" +xref: MassAvg: "225.27" +xref: MassMono: "225.057198" +xref: Origin: "C, S, S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01425 ! pyridinyl ring crosslinked residues + +[Term] +id: MOD:01395 +name: 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol +def: "A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol." [PubMed:11320328, RESID:AA0472] +comment: Cross-link 2. +synonym: "(7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline" EXACT RESID-systematic [] +synonym: "4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol" EXACT RESID-name [] +synonym: "BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links)" EXACT UniProt-feature [] +xref: DiffAvg: "215.21" +xref: DiffFormula: "C 12 H 9 N 1 O 3" +xref: DiffMono: "215.058243" +xref: Formula: "C 22 H 28 N 3 O 6" +xref: MassAvg: "430.48" +xref: MassMono: "430.197811" +xref: Origin: "I, T" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01424 ! quinaldate modified residue + +[Term] +id: MOD:01396 +name: 5-hydroxy-3-methyl-L-proline (Pro) +def: "A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline." [PubMed:7592021, PubMed:8557573, RESID:AA0473] +comment: This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG]. +synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name [] +synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate [] +synonym: "5Hy3MePro" EXACT PSI-MOD-label [] +synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate [] +synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature [] +xref: DiffAvg: "30.03" +xref: DiffFormula: "C 1 H 2 N 0 O 1" +xref: DiffMono: "30.010565" +xref: Formula: "C 6 H 9 N 1 O 2" +xref: MassAvg: "127.14" +xref: MassMono: "127.063329" +xref: Origin: "P" +xref: Source: "artifactual" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +relationship: has_functional_parent MOD:01024 ! monohydroxylated proline +relationship: has_functional_parent MOD:01417 ! monomethylated proline + +[Term] +id: MOD:01397 +name: L-serine 5-methyloxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0474] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr)" EXACT UniProt-feature [] +synonym: "L-serine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 8 N 2 O 3" +xref: MassAvg: "168.15" +xref: MassMono: "168.053492" +xref: Origin: "S, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01398 +name: N6-propanoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine." [PubMed:17267393, PubMed:17684016, PubMed:20715035, RESID:AA0475, UniMod:58#K] +comment: The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(propanoylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-6-propionylaminocaproic acid" EXACT RESID-alternate [] +synonym: "epsilon-propanoyl-L-lysine" EXACT RESID-alternate [] +synonym: "epsilon-propionyl-L-lysine" EXACT RESID-alternate [] +synonym: "N(zeta)-propanoyllysine" EXACT RESID-alternate [] +synonym: "N6-(1-oxopropyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-propanoyl-L-lysine" EXACT RESID-name [] +synonym: "N6-propionyllysine" EXACT RESID-alternate [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 N 0 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "C 9 H 16 N 2 O 2" +xref: MassAvg: "184.24" +xref: MassMono: "184.121178" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01155 ! lipoconjugated residue +is_a: MOD:01875 ! N6-acylated L-lysine +is_a: MOD:01894 ! propanoylated residue + +[Term] +id: MOD:01399 +name: N6-(ADP-ribosyl)-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine." [PubMed:18436469, RESID:AA0476] +synonym: "(S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-6-(ADP-ribosyl)amino-hexanoic acid" EXACT RESID-alternate [] +synonym: "epsilon-ADP-ribosyllysine" EXACT RESID-alternate [] +synonym: "MOD_RES N6-(ADP-ribosyl)lysine" EXACT UniProt-feature [] +synonym: "N(zeta)-ADP-ribosyllysine" EXACT RESID-alternate [] +synonym: "N6-(ADP-ribosyl)-L-lysine" EXACT RESID-name [] +synonym: "N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine" EXACT RESID-alternate [] +synonym: "N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 21 H 33 N 7 O 14 P 2" +xref: MassAvg: "669.48" +xref: MassMono: "669.156072" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01400 +name: L-lysyl-poly(ADP-ribose) +def: "A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose)." [PubMed:6772638, RESID:AA0477] +synonym: "L-lysyl-poly(ADP-ribose)" EXACT RESID-name [] +synonym: "MOD_RES Lysyl poly(ADP-ribose)" EXACT UniProt-feature [] +synonym: "poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate" EXACT RESID-systematic [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 21 H 34 N 7 O 15 P 2" +xref: MassAvg: "686.48" +xref: MassMono: "686.158812" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01401 +name: (2S,3S)-3-hydroxyasparagine +def: "A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine." [ChEBI:50789, PubMed:11823643, PubMed:12042299, PubMed:12215170, PubMed:17573339, RESID:AA0478] +subset: PSI-MOD-slim +synonym: "(2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid" EXACT RESID-alternate [] +synonym: "(2S,3S)-2-amino-3-hydroxy-4-butanediamic acid" EXACT RESID-systematic [] +synonym: "(2S,3S)-3-hydroxyasparagine" EXACT RESID-name [] +synonym: "(3S)3HyAsn" EXACT PSI-MOD-label [] +synonym: "L-threo-beta-hydroxyasparagine" EXACT RESID-alternate [] +synonym: "MOD_RES (3S)-3-hydroxyasparagine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 4 H 6 N 2 O 3" +xref: MassAvg: "130.10" +xref: MassMono: "130.037842" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01688 ! 3-hydroxy-L-asparagine + +[Term] +id: MOD:01402 +name: (2S,3R,4R)-3,4-dihydroxyproline +def: "A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline." [PubMed:6893271, RESID:AA0479] +synonym: "(2S,3R,4R)-3,4-dihydroxyproline" EXACT RESID-name [] +synonym: "(2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "2,3-trans-3,4-trans-3,4-dihydroxy-L-proline" EXACT RESID-alternate [] +synonym: "2-alpha-3-beta-4-alpha-3,4-dihydroxyproline" EXACT RESID-alternate [] +synonym: "MOD_RES (3R,4R)-3,4-dihydroxyproline" EXACT UniProt-feature [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00866 ! dihydroxylated proline + +[Term] +id: MOD:01403 +name: (2S)-4,5,5'-trihydroxyleucine +def: "A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine." [PubMed:6893271, RESID:AA0480] +synonym: "(2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-4,5,5'-trihydroxyleucine" EXACT RESID-name [] +synonym: "4,5,5'-trihydroxyleucine" EXACT RESID-alternate [] +synonym: "gamma,delta,delta'-trihydroxyleucine" EXACT RESID-alternate [] +synonym: "MOD_RES 4,5,4'-trihydroxyleucine" EXACT UniProt-feature [] +xref: DiffAvg: "48.00" +xref: DiffFormula: "C 0 H 0 N 0 O 3" +xref: DiffMono: "47.984744" +xref: Formula: "C 6 H 11 N 1 O 4" +xref: MassAvg: "161.16" +xref: MassMono: "161.068808" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01413 ! trihydroxylated leucine + +[Term] +id: MOD:01404 +name: L-asparagine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0481] +comment: Cross-link 2. +synonym: "2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys)" EXACT UniProt-feature [] +synonym: "L-asparagine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 7 N 3 O 2 S 1" +xref: MassAvg: "197.21" +xref: MassMono: "197.025897" +xref: Origin: "C, N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01405 +name: L-proline thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0482] +comment: Cross-link 2. +synonym: "2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys)" EXACT UniProt-feature [] +synonym: "L-proline thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 8 H 8 N 2 O 1 S 1" +xref: MassAvg: "180.22" +xref: MassMono: "180.035734" +xref: Origin: "C, P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01406 +name: L-threonine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid." [PubMed:11320328, RESID:AA0483] +comment: Cross-link 2. +synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys)" EXACT UniProt-feature [] +synonym: "L-threonine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 8 N 2 O 2 S 1" +xref: MassAvg: "184.21" +xref: MassMono: "184.030649" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01407 +name: L-phenylalanine thiazoline-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0484] +comment: Cross-link 2. +synonym: "(4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys)" EXACT UniProt-feature [] +synonym: "L-phenylalanine thiazoline-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 12 H 12 N 2 O 1 S 1" +xref: MassAvg: "232.30" +xref: MassMono: "232.067034" +xref: Origin: "C, F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues + +[Term] +id: MOD:01408 +name: L-threonine thiazoline-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid." [PubMed:11320328, RESID:AA0485] +comment: Cross-link 2. +synonym: "(4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys)" EXACT UniProt-feature [] +synonym: "L-threonine (4S)-thiazoline-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 10 N 2 O 2 S 1" +xref: MassAvg: "186.23" +xref: MassMono: "186.046299" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues + +[Term] +id: MOD:01409 +name: trihydroxylated residue +def: "A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups." [PubMed:18688235] +synonym: "Hy3Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "48.00" +xref: DiffFormula: "C 0 H 0 N 0 O 3" +xref: DiffMono: "47.984744" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue + +[Term] +id: MOD:01410 +name: hydroxylated leucine +def: "A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine." [PubMed:18688235] +synonym: "HyLeu" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "L" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00911 ! modified L-leucine residue + +[Term] +id: MOD:01411 +name: monohydroxylated leucine +def: "A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine." [PubMed:18688235] +synonym: "Hy1Leu" EXACT PSI-MOD-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 11 N 1 O 2" +xref: MassAvg: "129.16" +xref: MassMono: "129.078979" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:01410 ! hydroxylated leucine + +[Term] +id: MOD:01412 +name: dihydroxylated leucine +def: "A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine." [PubMed:18688235] +synonym: "Hy2Leu" EXACT PSI-MOD-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 11 N 1 O 3" +xref: MassAvg: "145.16" +xref: MassMono: "145.073893" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:01410 ! hydroxylated leucine + +[Term] +id: MOD:01413 +name: trihydroxylated leucine +def: "A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine." [PubMed:18688235] +synonym: "Hy3Leu" EXACT PSI-MOD-label [] +xref: DiffAvg: "48.00" +xref: DiffFormula: "C 0 H 0 N 0 O 3" +xref: DiffMono: "47.984744" +xref: Formula: "C 6 H 11 N 1 O 4" +xref: MassAvg: "161.16" +xref: MassMono: "161.068808" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01409 ! trihydroxylated residue +is_a: MOD:01410 ! hydroxylated leucine + +[Term] +id: MOD:01414 +name: hydroxylated isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine." [PubMed:18688235] +synonym: "HyIle" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "I" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue +is_a: MOD:00910 ! modified L-isoleucine residue + +[Term] +id: MOD:01415 +name: monohydroxylated isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine." [PubMed:18688235] +synonym: "Hy1Ile" EXACT PSI-MOD-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 11 N 1 O 2" +xref: MassAvg: "129.16" +xref: MassMono: "129.078979" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:01414 ! hydroxylated isoleucine + +[Term] +id: MOD:01416 +name: dihydroxylated isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine." [PubMed:18688235] +synonym: "Hy2Ile" EXACT PSI-MOD-label [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 11 N 1 O 3" +xref: MassAvg: "145.16" +xref: MassMono: "145.073893" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00428 ! dihydroxylated residue +is_a: MOD:01414 ! hydroxylated isoleucine + +[Term] +id: MOD:01417 +name: monomethylated proline +def: "A protein modification that effectively converts an L-proline residue to a monomethylated proline." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "Me1Pro" EXACT PSI-MOD-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 6 H 10 N 1 O 1" +xref: MassAvg: "112.15" +xref: MassMono: "112.076239" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00712 ! methylated proline + +[Term] +id: MOD:01418 +name: methylated threonine +def: "A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine." [PubMed:18688235] +synonym: "MeThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01419 +name: oxazole/oxazoline ring crosslinked residues +def: "A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid." [PubMed:18688235] +is_a: MOD:00690 ! oxazole/thiazole ring crosslinked residues + +[Term] +id: MOD:01420 +name: thiazole/thiazoline ring croslinked residues +def: "A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring." [PubMed:18688235] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00690 ! oxazole/thiazole ring crosslinked residues + +[Term] +id: MOD:01421 +name: oxazole/oxazoline ring crosslinked residues (Ser) +def: "A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring." [PubMed:18688235] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues + +[Term] +id: MOD:01422 +name: oxazole/oxazoline ring crosslinked residues (Thr) +def: "A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring." [PubMed:18688235] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues + +[Term] +id: MOD:01423 +name: palmitoleylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group." [UniMod:431] +subset: PSI-MOD-slim +xref: DiffAvg: "236.40" +xref: DiffFormula: "C 16 H 28 N 0 O 1" +xref: DiffMono: "236.214016" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:01424 +name: quinaldate modified residue +def: "A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group." [PubMed:18688235] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01425 +name: pyridinyl ring crosslinked residues +def: "A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid." [PubMed:18688235] +comment: Cross-link 3. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C, S, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01426 +name: isotope tagged reagent derivatized residue +def: "A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01427 +name: 2-aminobutanoic acid (Abu) +def: "OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819." [PubMed:18688235] +synonym: "Abu" EXACT DeltaMass-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 4 H 7 N 1 O 1" +xref: MassAvg: "85.11" +xref: MassMono: "85.052764" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01428 +name: (13)C isotope tagged reagent +def: "A protein modification that forms an adduct with a (13)C labeled compound used as a reagent." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01429 +name: (15)N isotope tagged reagent +def: "A protein modification that forms an adduct with a (15)N labeled compound used as a reagent." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01430 +name: (18)O isotope tagged reagent +def: "A protein modification that forms an adduct with a (13)C labeled compound used as a reagent." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01431 +name: (2)H deuterium tagged reagent +def: "A protein modification that forms an adduct with a (2)H labeled compound used as a reagent." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01432 +name: (2S,4S)-4,5-dihydroxyleucine +def: "A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine." [PubMed:3718926, RESID:AA0446] +synonym: "(2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,4S)-4,5-dihydroxyleucine" EXACT RESID-name [] +synonym: "(4S)-4,5-dihydroxyleucine" EXACT RESID-alternate [] +synonym: "gamma,delta-dihydroxyleucine" EXACT RESID-alternate [] +xref: DiffAvg: "32.00" +xref: DiffFormula: "C 0 H 0 N 0 O 2" +xref: DiffMono: "31.989829" +xref: Formula: "C 6 H 11 N 1 O 3" +xref: MassAvg: "145.16" +xref: MassMono: "145.073893" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01412 ! dihydroxylated leucine + +[Term] +id: MOD:01433 +name: 1-amino-2-propanone +def: "A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone." [ChEBI:17906, PubMed:12715872, PubMed:19196969, RESID:AA0486] +synonym: "1-amino-2-propanone" EXACT RESID-name [] +synonym: "1-aminopropan-2-one" EXACT RESID-alternate [] +synonym: "1-aminopropanone" EXACT RESID-systematic [] +synonym: "aminoacetone" EXACT RESID-alternate [] +synonym: "MOD_RES 1-amino-2-propanone" EXACT UniProt-feature [] +xref: DiffAvg: "-46.03" +xref: DiffFormula: "C -1 H -2 N 0 O -2" +xref: DiffMono: "-46.005479" +xref: Formula: "C 3 H 6 N 1 O 1" +xref: MassAvg: "72.09" +xref: MassMono: "72.044939" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00683 ! dehydrogenated residue +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:00960 ! decarboxylated residue + +[Term] +id: MOD:01434 +name: 4-hydroxy-L-glutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid." [PubMed:893891, RESID:AA0487] +synonym: "(2S,4Xi)-2-amino-4-hydroxypentanedioic acid" EXACT RESID-systematic [] +synonym: "4-hydroxy-L-glutamic acid" EXACT RESID-name [] +synonym: "gamma-hydroxy glutaminic acid" EXACT RESID-alternate [] +synonym: "MOD_RES 4-hydroxyglutamate" EXACT UniProt-feature [] +synonym: "threo-4-hydroxy-L-glutamic acid" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 7 N 1 O 4" +xref: MassAvg: "145.11" +xref: MassMono: "145.037508" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01435 +name: 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole +def: "A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole." [PubMed:893891, RESID:AA0488] +comment: Cross-link 2. +synonym: "2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole" EXACT RESID-systematic [] +synonym: "2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole" EXACT RESID-name [] +synonym: "2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole" EXACT RESID-alternate [] +synonym: "BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links)" EXACT UniProt-feature [] +xref: DiffAvg: "169.18" +xref: DiffFormula: "C 11 H 7 N 1 O 1 S 0" +xref: DiffMono: "169.052764" +xref: Formula: "C 19 H 19 N 3 O 5 S 1" +xref: MassAvg: "401.44" +xref: MassMono: "401.104542" +xref: Origin: "C, E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00672 ! S-acylated residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01436 +name: cyclo[(prolylserin)-O-yl] cysteinate (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate." [PubMed:7961166, RESID:AA0489#CYS] +synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate [] +synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] +synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name [] +synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature [] +xref: DiffAvg: "166.18" +xref: DiffFormula: "C 8 H 10 N 2 O 2 S 0" +xref: DiffMono: "166.074228" +xref: Formula: "C 11 H 16 N 3 O 4 S 1" +xref: MassAvg: "286.33" +xref: MassMono: "286.086152" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01629 ! cyclo[(prolylserin)-O-yl] cysteinate + +[Term] +id: MOD:01437 +name: cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link) +def: "A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate." [PubMed:7961166, RESID:AA0489#TRI] +comment: Cross-link 3. +synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate [] +synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] +synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name [] +synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 11 H 16 N 3 O 4 S 1" +xref: MassAvg: "286.33" +xref: MassMono: "286.086152" +xref: Origin: "C, P, S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01629 ! cyclo[(prolylserin)-O-yl] cysteinate + +[Term] +id: MOD:01438 +name: S-[2-(pyridin-2-yl)ethyl]-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine." [PubMed:18369855, PubMed:18688235] +comment: From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286 +synonym: "2-PEC" EXACT PSI-MOD-alternate [] +synonym: "2-vinylpyridine derivatized cysteine residue" EXACT PSI-MOD-alternate [] +synonym: "Pyridylethyl" RELATED PSI-MS-label [] +synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label [] +synonym: "S-(pyridin-2-ylethyl)-L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-pyridylethylation" RELATED UniMod-description [] +xref: DiffAvg: "105.14" +xref: DiffFormula: "C 7 H 7 N 1" +xref: DiffMono: "105.057849" +xref: Formula: "C 10 H 12 N 2 O 1 S 1" +xref: MassAvg: "208.28" +xref: MassMono: "208.067034" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00424 ! S-pyridylethyl-L-cysteine + +[Term] +id: MOD:01439 +name: S-[2-(pyridin-4-yl)ethyl]-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine." [PubMed:18688235, PubMed:6528972] +synonym: "4-PEC" EXACT PSI-MOD-alternate [] +synonym: "Pyridylethyl" RELATED PSI-MS-label [] +synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label [] +synonym: "S-(pyridin-4-ylethyl)-L-cysteine" EXACT PSI-MOD-alternate [] +synonym: "S-pyridylethylation" RELATED UniMod-description [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00424 ! S-pyridylethyl-L-cysteine + +[Term] +id: MOD:01440 +name: glutamyl semialdehyde +def: "A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde." [PubMed:18688235] +synonym: "(S)-2-amino-5-oxopentanoic acid" EXACT PSI-MOD-alternate [] +synonym: "L-glutamic gamma-semialdehyde" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01441 +name: natural, standard, encoded residue +def: "A protein modification that inserts or replaces a residue with a natural, standard, encoded residue." [PubMed:18688235, PubMed:6692818] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00009 ! natural residue + +[Term] +id: MOD:01442 +name: 3-(O4'-L-tyrosyl)-L-valine +def: "A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine." [PubMed:19321420, RESID:AA0490] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "3-(O4'-L-tyrosyl)-L-valine" EXACT RESID-name [] +synonym: "CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 14 H 16 N 2 O 3" +xref: MassAvg: "260.29" +xref: MassMono: "260.116092" +xref: Origin: "V, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:00920 ! modified L-valine residue + +[Term] +id: MOD:01443 +name: tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide +def: "A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide." [PubMed:19321420, RESID:AA0491] +comment: Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG]. +xref: DiffAvg: "350.12" +xref: DiffFormula: "C 14 Fe 1 H 23 Mn 1 N 0 O 3" +xref: DiffMono: "350.038251" +xref: FormalCharge: "1-" +xref: Formula: "C 46 Fe 1 H 65 Mn 1 N 10 O 17" +xref: MassAvg: "1140.86" +xref: MassMono: "1140.326447" +xref: Origin: "E, E, E, E, H, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00438 ! myristoylated residue +is_a: MOD:00738 ! iron containing modified residue +is_a: MOD:00740 ! manganese containing modified residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00909 ! modified L-histidine residue + +[Term] +id: MOD:01444 +name: L-3,3-dihydroxyoalanine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492#CYS] +synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate [] +synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name [] +synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate [] +synonym: "3-hydroxy-L-serine" EXACT RESID-alternate [] +synonym: "3-oxoalanine hydrate" EXACT RESID-alternate [] +synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer [] +xref: DiffAvg: "-0.06" +xref: DiffFormula: "C 0 H 0 N 0 O 2 S -1" +xref: DiffMono: "0.017758" +xref: Formula: "C 3 H 5 N 1 O 3" +xref: MassAvg: "103.08" +xref: MassMono: "103.026943" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01448 ! L-3,3-dihydroxyoalanine + +[Term] +id: MOD:01445 +name: L-3,3-dihydroxyoalanine (Ser) +def: "A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492#SER] +synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate [] +synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name [] +synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate [] +synonym: "3-hydroxy-L-serine" EXACT RESID-alternate [] +synonym: "3-oxoalanine hydrate" EXACT RESID-alternate [] +synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 3 H 5 N 1 O 3" +xref: MassAvg: "103.08" +xref: MassMono: "103.026943" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01448 ! L-3,3-dihydroxyoalanine + +[Term] +id: MOD:01446 +name: N-(dihydroxymethyl)-L-methionine (fMet) +def: "A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine." [PubMed:12595263, PubMed:9159480, RESID:AA0493] +synonym: "(2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "N-(dihydroxymethyl)-L-methionine" EXACT RESID-name [] +synonym: "N-formyl-L-methionine hydrate" EXACT RESID-alternate [] +synonym: "N-orthoformylmethionine" EXACT RESID-alternate [] +xref: DiffAvg: "18.02" +xref: DiffFormula: "C 0 H 2 N 0 O 1 S 0" +xref: DiffMono: "18.010565" +xref: Formula: "C 6 H 12 N 1 O 3 S 1" +xref: MassAvg: "178.23" +xref: MassMono: "178.053789" +xref: Origin: "MOD:00030" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:01450 ! modified N-formyl-L-methionine residue +relationship: derives_from MOD:00030 ! N-formyl-L-methionine residue + +[Term] +id: MOD:01447 +name: N-(dihydroxymethyl)-L-methionine (Met) +def: "A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process)." [PubMed:12595263, PubMed:9159480, RESID:AA0493] +comment: This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446. +synonym: "(2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "N-(dihydroxymethyl)-L-methionine" EXACT RESID-name [] +synonym: "N-formyl-L-methionine hydrate" EXACT RESID-alternate [] +synonym: "N-orthoformylmethionine" EXACT RESID-alternate [] +xref: DiffAvg: "46.03" +xref: DiffFormula: "C 1 H 2 N 0 O 2 S 0" +xref: DiffMono: "46.005479" +xref: Formula: "C 6 H 12 N 1 O 3 S 1" +xref: MassAvg: "178.23" +xref: MassMono: "178.053789" +xref: Origin: "M" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:01448 +name: L-3,3-dihydroxyoalanine +def: "A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492] +synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate [] +synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name [] +synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate [] +synonym: "3-hydroxy-L-serine" EXACT RESID-alternate [] +synonym: "3-oxoalanine hydrate" EXACT RESID-alternate [] +synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 3 H 5 N 1 O 3" +xref: MassAvg: "103.08" +xref: MassMono: "103.026943" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01449 +name: L-3,3-dihydroxyoalanine (Oxoalanine) +def: "A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, PubMed:18688235] +xref: DiffAvg: "18.02" +xref: DiffFormula: "C 0 H 2 N 0 O 1" +xref: DiffMono: "18.010565" +xref: Formula: "C 3 H 5 N 1 O 3" +xref: MassAvg: "103.08" +xref: MassMono: "103.026943" +xref: Origin: "MOD:01169" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01448 ! L-3,3-dihydroxyoalanine +relationship: derives_from MOD:01169 ! L-3-oxoalanine + +[Term] +id: MOD:01450 +name: modified N-formyl-L-methionine residue +def: "A protein modification that modifies an N-formyl-L-methionine residue." [PubMed:18688235] +xref: Origin: "MOD:00030" +xref: TermSpec: "N-term" +is_a: MOD:01157 ! protein modification categorized by amino acid modified +relationship: derives_from MOD:00030 ! N-formyl-L-methionine residue + +[Term] +id: MOD:01451 +name: O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine +def: "A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine." [PubMed:17042494, PubMed:18688235] +comment: Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin. +subset: PSI-MOD-slim +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 3 H 6 N 1 O 5 P 1" +xref: MassAvg: "167.06" +xref: MassMono: "166.998359" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00046 ! O-phospho-L-serine +is_a: MOD:00431 ! modified residue with a secondary neutral loss +relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine + +[Term] +id: MOD:01452 +name: O-phosphopantetheine-L-serine with neutral loss of pantetheine +def: "Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine." [PubMed:17042494, PubMed:18688235] +comment: Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin. +subset: PSI-MOD-slim +xref: DiffAvg: "-260.35" +xref: DiffFormula: "C -11 H -20 N -2 O -3 P 0 S -1" +xref: DiffMono: "-260.119464" +xref: Formula: "C 3 H 6 N 1 O 5 P 1" +xref: MassAvg: "167.06" +xref: MassMono: "166.998359" +xref: Origin: "MOD:00159" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00046 ! O-phospho-L-serine +is_a: MOD:00431 ! modified residue with a secondary neutral loss +relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine + +[Term] +id: MOD:01453 +name: L-glutamic acid 5-methyl ester +def: "A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester." [RESID:AA0072] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate [] +synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate [] +synonym: "5-methyl esterified L-glutamic acid" EXACT PSI-MOD-alternate [] +synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate [] +synonym: "5-methyl L-glutamate" EXACT RESID-alternate [] +synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate [] +synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate [] +synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name [] +synonym: "O-methyl Glutamyl" EXACT DeltaMass-label [] +synonym: "O5MeGlu" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 9 N 1 O 3" +xref: MassAvg: "143.14" +xref: MassMono: "143.058243" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00393 ! O-methylated residue +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00713 ! methylated glutamic acid +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01454 +name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium +def: "A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium." [PubMed:10833024, PubMed:11847126, PubMed:9030608, RESID:AA0494] +comment: This linkage is not a Schiff-base [JSG]. +synonym: "(1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium" EXACT RESID-systematic [] +synonym: "DNA glycosylase proline Schiff base intermediate" RELATED RESID-misnomer [] +synonym: "N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium" EXACT RESID-name [] +xref: DiffAvg: "179.09" +xref: DiffFormula: "C 5 H 8 N 0 O 5 P 1" +xref: DiffMono: "179.010386" +xref: FormalCharge: "1+" +xref: Formula: "C 10 H 16 N 1 O 6 P 1" +xref: MassAvg: "277.21" +xref: MassMono: "277.070975" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00750 ! deoxyribonucleic acid linked residue +is_a: MOD:00915 ! modified L-proline residue + +[Term] +id: MOD:01455 +name: O-phosphorylated residue +def: "A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate')." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OPhosRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "H 1 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00696 ! phosphorylated residue + +[Term] +id: MOD:01456 +name: N-phosphorylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate')." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OPhosRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "H 1 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00696 ! phosphorylated residue + +[Term] +id: MOD:01457 +name: L-cysteine (Ser) +def: "A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process)." [PubMed:1849824, PubMed:18688235] +synonym: "Cys(Ser)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-16.06" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S -1" +xref: DiffMono: "-15.977156" +xref: Formula: "C 3 H 5 N 1 O 1 S 1" +xref: MassAvg: "103.14" +xref: MassMono: "103.009185" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00014 ! L-cysteine residue +is_a: MOD:00749 ! sulfur substitution for oxygen +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01458 +name: alpha-amino acetylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group." [OMSSA:10, UniMod:1#N-term] +subset: PSI-MOD-slim +synonym: "N2AcRes" EXACT PSI-MOD-label [] +synonym: "ntermacetyl" EXACT OMSSA-label [] +xref: DiffAvg: "42.04" +xref: DiffFormula: "C 2 H 2 N 0 O 1" +xref: DiffMono: "42.010565" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00408 ! N-acetylated residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:01459 +name: 4x(2)H labeled alpha-dimethylamino N-terminal residue +def: "A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue." [OMSSA:190, PubMed:14670044, UniMod:199#N-term] +comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. +subset: PSI-MOD-slim +synonym: "DiMethyl-CHD2" RELATED UniMod-description [] +synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label [] +synonym: "mod190" EXACT OMSSA-label [] +xref: DiffAvg: "32.06" +xref: DiffFormula: "C 2 (2)H 4" +xref: DiffMono: "32.056407" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00552 ! 4x(2)H labeled dimethylated residue + +[Term] +id: MOD:01460 +name: alpha-amino methylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "N2MeRes" EXACT PSI-MOD-label [] +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00602 ! N-methylated residue + +[Term] +id: MOD:01461 +name: N-methylated alanine +def: "A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00665 ! methylated alanine +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01462 +name: N-methylated proline +def: "A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00712 ! methylated proline +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01463 +name: N-methylated methionine +def: "A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00716 ! methylated methionine +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01464 +name: protonated L-methionine (L-methioninium) residue +def: "A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine)." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0 S 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 11 N 1 O 1 S 1" +xref: MassAvg: "133.21" +xref: MassMono: "133.055586" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01700 ! alpha-amino protonated residue + +[Term] +id: MOD:01465 +name: N,N,N-trimethyl-L-methionine (from L-methioninium) +def: "A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine." [PubMed:18688235] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "N2Me3Met" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0 S 0" +xref: DiffMono: "42.046402" +xref: FormalCharge: "1+" +xref: Formula: "C 8 H 17 N 1 O 1 S 1" +xref: MassAvg: "175.29" +xref: MassMono: "175.102537" +xref: Origin: "MOD:001464" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01687 ! alpha-amino trimethylated residue +relationship: derives_from MOD:01464 ! protonated L-methionine (L-methioninium) residue + +[Term] +id: MOD:01466 +name: menadione quinone derivative - site C +def: "modification from UniMod Chemical derivative" [PubMed:15939799, UniMod:302#K] +synonym: "Menadione" RELATED UniMod-interim [] +synonym: "Menadione quinone derivative" RELATED UniMod-description [] +xref: DiffAvg: "170.17" +xref: DiffFormula: "C 11 H 6 O 2" +xref: DiffMono: "170.036779" +xref: Formula: "C 14 H 11 N 1 O 3 S 1" +xref: MassAvg: "273.31" +xref: MassMono: "273.045964" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00621 ! menadione quinone derivative +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01467 +name: menadione quinone derivative - site K +def: "modification from UniMod Chemical derivative" [PubMed:15939799, UniMod:302#K] +synonym: "Menadione" RELATED UniMod-interim [] +synonym: "Menadione quinone derivative" RELATED UniMod-description [] +xref: DiffAvg: "170.17" +xref: DiffFormula: "C 11 H 6 O 2" +xref: DiffMono: "170.036779" +xref: Formula: "C 17 H 18 N 2 O 3" +xref: MassAvg: "298.34" +xref: MassMono: "298.131742" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00621 ! menadione quinone derivative +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01468 +name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process)." [PubMed:14235557, PubMed:2211698, PubMed:8052647, PubMed:9036855, RESID:AA0248#CYS, UniMod:415] +comment: This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253. +synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] +synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum" EXACT RESID-systematic [] +synonym: "formate dehydrogenase selenocysteine molybdenum cofactor" EXACT RESID-alternate [] +synonym: "L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] +synonym: "L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] +synonym: "molybdopterin-se" RELATED UniMod-interim [] +synonym: "MolybdopterinGD+Delta:S(-1)Se(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "1618.93" +xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1" +xref: DiffMono: "1620.930226" +xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1" +xref: MassAvg: "1722.07" +xref: MassMono: "1723.939410" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00744 ! molybdenum pterin containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01469 +name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process)." [PubMed:11372198, PubMed:12220497, RESID:AA0376#CYS] +comment: This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381. +xref: DiffAvg: "1738.88" +xref: DiffFormula: "C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1" +xref: DiffMono: "1738.947820" +xref: Formula: "C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1" +xref: MassAvg: "1842.02" +xref: MassMono: "1841.957004" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00746 ! tungsten containing modified residue +is_a: MOD:00748 ! pterin modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01470 +name: (E)-dehydrobutyrine (Thr) +def: "A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine." [DeltaMass:0, PubMed:1547888, PubMed:20805503, PubMed:3769923, RESID:AA0547] +subset: PSI-MOD-slim +synonym: "(2E)-2-aminobut-2-enoic acid" EXACT RESID-systematic [] +synonym: "(E)-2-amino-2-butenoic acid" EXACT RESID-alternate [] +synonym: "(E)-2-aminobutenoic acid" EXACT RESID-alternate [] +synonym: "(E)-dehydrobutyrine" EXACT RESID-name [] +synonym: "(E)dHAbu" EXACT PSI-MOD-label [] +synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate [] +synonym: "3-methyldehydroalanine" EXACT RESID-alternate [] +synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate [] +synonym: "anhydrothreonine" EXACT RESID-alternate [] +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] +synonym: "Dhb" EXACT RESID-alternate [] +synonym: "methyl-dehydroalanine" EXACT RESID-alternate [] +synonym: "MOD_RES (E)-2,3-didehydrobutyrine" EXACT UniProt-feature [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00190 ! dehydrobutyrine (Thr) + +[Term] +id: MOD:01471 +name: (Z)-dehydrobutyrine (Thr) +def: "A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine." [DeltaMass:0, PubMed:1547888, PubMed:3769923, RESID:AA0182] +subset: PSI-MOD-slim +synonym: "(2Z)-2-aminobut-2-enoic acid" EXACT RESID-systematic [] +synonym: "(Z)-2-amino-2-butenoic acid" EXACT RESID-alternate [] +synonym: "(Z)-2-aminobutenoic acid" EXACT RESID-alternate [] +synonym: "(Z)-dehydrobutyrine" EXACT RESID-name [] +synonym: "(Z)dHAbu" EXACT PSI-MOD-label [] +synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate [] +synonym: "3-methyldehydroalanine" EXACT RESID-alternate [] +synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate [] +synonym: "anhydrothreonine" EXACT RESID-alternate [] +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] +synonym: "Dhb" EXACT RESID-alternate [] +synonym: "methyl-dehydroalanine" EXACT RESID-alternate [] +synonym: "MOD_RES (Z)-2,3-didehydrobutyrine" EXACT UniProt-feature [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00190 ! dehydrobutyrine (Thr) + +[Term] +id: MOD:01472 +name: reduced residue +def: "A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "RedRes" EXACT PSI-MOD-label [] +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01473 +name: hydrogenated residue +def: "A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "HRes" EXACT PSI-MOD-label [] +is_a: MOD:01472 ! reduced residue + +[Term] +id: MOD:01474 +name: O-[S-(carboxymethyl)phosphopantetheine]-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine." [PubMed:18688235] +comment: This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG]. +xref: DiffAvg: "398.37" +xref: DiffFormula: "C 13 H 23 N 2 O 8 P 1 S 1" +xref: DiffMono: "398.091273" +xref: Formula: "C 16 H 28 N 3 O 10 P 1 S 1" +xref: MassAvg: "485.44" +xref: MassMono: "485.123302" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00399 ! iodoacetic acid derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue +relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine + +[Term] +id: MOD:01475 +name: O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine." [PubMed:18688235] +comment: This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG]. +xref: DiffAvg: "397.38" +xref: DiffFormula: "C 13 H 24 N 3 O 7 P 1 S 1" +xref: DiffMono: "397.107258" +xref: Formula: "C 16 H 29 N 4 O 9 P 1 S 1" +xref: MassAvg: "484.46" +xref: MassMono: "484.139286" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue +relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine + +[Term] +id: MOD:01476 +name: 2'-fluoro-L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898] +synonym: "2-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "o-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "ortho-fluorophenylalanine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" +xref: DiffMono: "17.990578" +xref: Formula: "C 9 F 1 H 8 N 1 O 1" +xref: MassAvg: "165.17" +xref: MassMono: "165.058992" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01227 ! monofluorinated L-phenylalanine + +[Term] +id: MOD:01477 +name: 3'-fluoro-L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898] +synonym: "3-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "m-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "meta-fluorophenylalanine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" +xref: DiffMono: "17.990578" +xref: Formula: "C 9 F 1 H 8 N 1 O 1" +xref: MassAvg: "165.17" +xref: MassMono: "165.058992" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01227 ! monofluorinated L-phenylalanine + +[Term] +id: MOD:01478 +name: 4'-fluoro-L-phenylalanine +def: "A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898] +synonym: "4-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "p-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "para-fluorophenylalanine" EXACT PSI-MOD-alternate [] +synonym: "rho-fluorophenylalanine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" +xref: DiffMono: "17.990578" +xref: Formula: "C 9 F 1 H 8 N 1 O 1" +xref: MassAvg: "165.17" +xref: MassMono: "165.058992" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01227 ! monofluorinated L-phenylalanine + +[Term] +id: MOD:01479 +name: 4'-fluoro-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898] +synonym: "4-fluorotryptophan" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "F 1 H -1" +xref: DiffMono: "17.990578" +xref: Formula: "C 11 F 1 H 9 N 2 O 1" +xref: MassAvg: "204.20" +xref: MassMono: "204.069891" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01226 ! monofluorinated L-tryptophan + +[Term] +id: MOD:01480 +name: 5'-fluoro-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898] +synonym: "5-fluorotryptophan" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "F 1 H -1" +xref: DiffMono: "17.990578" +xref: Formula: "C 11 F 1 H 9 N 2 O 1" +xref: MassAvg: "204.20" +xref: MassMono: "204.069891" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01226 ! monofluorinated L-tryptophan + +[Term] +id: MOD:01481 +name: 6'-fluoro-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898] +synonym: "6-fluorotryptophan" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "F 1 H -1" +xref: DiffMono: "17.990578" +xref: Formula: "C 11 F 1 H 9 N 2 O 1" +xref: MassAvg: "204.20" +xref: MassMono: "204.069891" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01226 ! monofluorinated L-tryptophan + +[Term] +id: MOD:01482 +name: calcium containing modified residue +def: "A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "CaRes" EXACT PSI-MOD-label [] +is_a: MOD:00698 ! metal or metal cluster containing modified residue + +[Term] +id: MOD:01483 +name: O-formylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group." [PubMed:18688235] +synonym: "OFoRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00493 ! formylated residue +is_a: MOD:00671 ! O-acylated residue + +[Term] +id: MOD:01484 +name: N6-(L-isoglutamyl)-L-lysine (Glu) +def: "A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water." [ChEBI:21863, PubMed:19015515, RESID:AA0124#GLU] +comment: Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP. +synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate [] +synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate [] +synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label [] +synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate [] +synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 11 H 17 N 3 O 3" +xref: MassAvg: "239.27" +xref: MassMono: "239.126991" +xref: Origin: "K, E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01630 ! N6-(L-isoglutamyl)-L-lysine + +[Term] +id: MOD:01485 +name: iTRAQ4plex-114 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [UniMod:532] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 114" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ114" RELATED UniMod-interim [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01430 ! (18)O isotope tagged reagent +is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. +is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01486 +name: iTRAQ4plex-114 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:167, UniMod:532#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 114" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ114" RELATED UniMod-interim [] +synonym: "iTRAQ114nterm" EXACT OMSSA-label [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue +is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01487 +name: iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:168, UniMod:532#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 114" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ114" RELATED UniMod-interim [] +synonym: "iTRAQ114K" EXACT OMSSA-label [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "(12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1" +xref: MassAvg: "272.20" +xref: MassMono: "272.200882" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01488 +name: iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:169, UniMod:532#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 114" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ114" RELATED UniMod-interim [] +synonym: "iTRAQ114Y" EXACT OMSSA-label [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "(12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1" +xref: MassAvg: "307.17" +xref: MassMono: "307.169248" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01489 +name: iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "(12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1" +xref: MassAvg: "281.16" +xref: MassMono: "281.164831" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01490 +name: iTRAQ4plex-114 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "(12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1" +xref: MassAvg: "231.14" +xref: MassMono: "231.137947" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01491 +name: iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] +xref: DiffAvg: "144.11" +xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" +xref: DiffMono: "144.105919" +xref: Formula: "(12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1" +xref: MassAvg: "245.15" +xref: MassMono: "245.153598" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01492 +name: iTRAQ4plex-115 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [UniMod:533] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ115" RELATED UniMod-interim [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01430 ! (18)O isotope tagged reagent +is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. +is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01493 +name: iTRAQ4plex-115 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:170, UniMod:533#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ115" RELATED UniMod-interim [] +synonym: "iTRAQ115nterm" EXACT OMSSA-label [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue +is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01494 +name: iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:171, UniMod:533#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ115" RELATED UniMod-interim [] +synonym: "iTRAQ115K" EXACT OMSSA-label [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "(12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1" +xref: MassAvg: "272.19" +xref: MassMono: "272.194562" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01495 +name: iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:172, UniMod:533#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ115" RELATED UniMod-interim [] +synonym: "iTRAQ115Y" EXACT OMSSA-label [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "(12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1" +xref: MassAvg: "307.16" +xref: MassMono: "307.162928" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01496 +name: iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "(12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1" +xref: MassAvg: "281.16" +xref: MassMono: "281.158511" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01497 +name: iTRAQ4plex-115 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "(12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1" +xref: MassAvg: "231.13" +xref: MassMono: "231.131628" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01498 +name: iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" +xref: DiffMono: "144.099599" +xref: Formula: "(12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1" +xref: MassAvg: "245.15" +xref: MassMono: "245.147278" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01499 +name: iTRAQ4plex-116 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [UniMod:214] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01517 ! modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da +is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01500 +name: iTRAQ4plex-116 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:173, UniMod:214#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ116nterm" EXACT OMSSA-label [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue +is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01501 +name: iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:174, UniMod:214#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ116K" EXACT OMSSA-label [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1" +xref: MassAvg: "272.20" +xref: MassMono: "272.197025" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01502 +name: iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:175, UniMod:214#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ116Y" EXACT OMSSA-label [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1" +xref: MassAvg: "307.17" +xref: MassMono: "307.165391" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01503 +name: iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2" +xref: MassAvg: "281.16" +xref: MassMono: "281.160974" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01504 +name: iTRAQ4plex-116 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3" +xref: MassAvg: "231.13" +xref: MassMono: "231.134091" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01505 +name: iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3" +xref: MassAvg: "245.15" +xref: MassMono: "245.149741" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01506 +name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [UniMod:214, UniMod:889] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "mTRAQ heavy" RELATED UniMod-description [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01517 ! modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da +is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue +is_a: MOD:01863 ! mTRAQ reporter+balance reagent acylated residue + +[Term] +id: MOD:01507 +name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:176, OMSSA:211, UniMod:214#N-term, UniMod:889N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ117nterm" EXACT OMSSA-label [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "mTRAQ heavy" RELATED UniMod-description [] +synonym: "mTRAQ heavy on nterm" EXACT OMSSA-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01508 +name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:177, OMSSA:212, UniMod:214#K, UniMod:889#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ117K" EXACT OMSSA-label [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "mTRAQ heavy" RELATED UniMod-description [] +synonym: "mTRAQ heavy on K" EXACT OMSSA-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1" +xref: MassAvg: "272.20" +xref: MassMono: "272.197025" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01509 +name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:178, OMSSA:213, UniMod:214#Y, UniMod:889#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "iTRAQ" RELATED UniMod-interim [] +synonym: "iTRAQ117Y" EXACT OMSSA-label [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +synonym: "mTRAQ heavy" RELATED UniMod-description [] +synonym: "mTRAQ heavy on Y" EXACT OMSSA-label [] +synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1" +xref: MassAvg: "307.17" +xref: MassMono: "307.165391" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01510 +name: iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2" +xref: MassAvg: "281.16" +xref: MassMono: "281.160974" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01511 +name: iTRAQ4plex-117 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3" +xref: MassAvg: "231.13" +xref: MassMono: "231.134091" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01512 +name: iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "iTRAQ4plex" RELATED PSI-MS-label [] +xref: DiffAvg: "144.10" +xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" +xref: DiffMono: "144.102062" +xref: Formula: "(12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3" +xref: MassAvg: "245.15" +xref: MassMono: "245.149741" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue +is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01513 +name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da +def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00538 ! protein modification categorized by isobaric sets + +[Term] +id: MOD:01514 +name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da +def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01513 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da + +[Term] +id: MOD:01515 +name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da +def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da + +[Term] +id: MOD:01516 +name: modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. +def: "Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da + +[Term] +id: MOD:01517 +name: modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da +def: "Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da +is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. + +[Term] +id: MOD:01518 +name: iTRAQ4plex reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [UniMod:214] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01705 ! isotope tagged reagent acylated residue + +[Term] +id: MOD:01519 +name: reporter fragment +def: "A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process." [PubMed:18688235] +comment: The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present. +subset: PSI-MOD-slim +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01520 +name: modification reporter fragment +def: "A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01519 ! reporter fragment + +[Term] +id: MOD:01521 +name: iTRAQ4plex reporter fragment +def: "A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01520 ! modification reporter fragment + +[Term] +id: MOD:01522 +name: iTRAQ4plex-114 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 2" +xref: MassAvg: "114.11" +xref: MassMono: "114.110680" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01521 ! iTRAQ4plex reporter fragment +relationship: derives_from MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue + +[Term] +id: MOD:01523 +name: iTRAQ4plex-115 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1" +xref: MassAvg: "115.11" +xref: MassMono: "115.107715" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01521 ! iTRAQ4plex reporter fragment +relationship: derives_from MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue + +[Term] +id: MOD:01524 +name: iTRAQ4plex-116 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1" +xref: MassAvg: "116.11" +xref: MassMono: "116.111069" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01521 ! iTRAQ4plex reporter fragment +relationship: derives_from MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue + +[Term] +id: MOD:01525 +name: iTRAQ4plex-117, mTRAQ heavy, reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1" +xref: MassAvg: "117.11" +xref: MassMono: "117.114424" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01521 ! iTRAQ4plex reporter fragment +is_a: MOD:01870 ! mTRAQ reporter fragment +relationship: derives_from MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue + +[Term] +id: MOD:01526 +name: iTRAQ8plex reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [UniMod:730] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01705 ! isotope tagged reagent acylated residue + +[Term] +id: MOD:01527 +name: residue reporter fragment +def: "A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01519 ! reporter fragment + +[Term] +id: MOD:01528 +name: iTRAQ8plex-113 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da + +[Term] +id: MOD:01529 +name: iTRAQ8plex-113 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01530 +name: iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" +xref: MassAvg: "432.30" +xref: MassMono: "432.300322" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01531 +name: iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "467.27" +xref: MassMono: "467.268688" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01532 +name: iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.264271" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01533 +name: iTRAQ8plex-113 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "391.24" +xref: MassMono: "391.237388" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01534 +name: iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.253038" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01535 +name: iTRAQ8plex-114 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da + +[Term] +id: MOD:01536 +name: iTRAQ8plex-114 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01537 +name: iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" +xref: MassAvg: "432.30" +xref: MassMono: "432.300322" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01538 +name: iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "467.27" +xref: MassMono: "467.268688" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01539 +name: iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.264271" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01540 +name: iTRAQ8plex-114 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "391.24" +xref: MassMono: "391.237388" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01541 +name: iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.253038" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01542 +name: iTRAQ8plex-115 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da + +[Term] +id: MOD:01543 +name: iTRAQ8plex-115 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01544 +name: iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" +xref: MassAvg: "432.29" +xref: MassMono: "432.294002" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01545 +name: iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "467.26" +xref: MassMono: "467.262368" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01546 +name: iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.257951" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01547 +name: iTRAQ8plex-115 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "391.23" +xref: MassMono: "391.231068" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01548 +name: iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.246718" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01549 +name: iTRAQ8plex-116 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da + +[Term] +id: MOD:01550 +name: iTRAQ8plex-116 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01551 +name: iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" +xref: MassAvg: "432.30" +xref: MassMono: "432.300322" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01552 +name: iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "467.27" +xref: MassMono: "467.268688" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01553 +name: iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.264271" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01554 +name: iTRAQ8plex-116 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "391.24" +xref: MassMono: "391.237388" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01555 +name: iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.253038" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01556 +name: iTRAQ8plex-117 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da + +[Term] +id: MOD:01557 +name: iTRAQ8plex-117 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01558 +name: iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" +xref: MassAvg: "432.30" +xref: MassMono: "432.300322" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01559 +name: iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex" RELATED UniMod-interim [] +synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] +synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "467.27" +xref: MassMono: "467.268688" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01560 +name: iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.264271" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01561 +name: iTRAQ8plex-117 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "391.24" +xref: MassMono: "391.237388" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01562 +name: iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.21" +xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" +xref: DiffMono: "304.205359" +xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.253038" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01563 +name: iTRAQ8plex-118 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da + +[Term] +id: MOD:01564 +name: iTRAQ8plex-118 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01565 +name: iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" +xref: MassAvg: "432.29" +xref: MassMono: "432.294002" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01566 +name: iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "467.26" +xref: MassMono: "467.262368" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01567 +name: iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.257951" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01568 +name: iTRAQ8plex-118 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "391.23" +xref: MassMono: "391.231068" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01569 +name: iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.246718" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01570 +name: iTRAQ8plex-119 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da + +[Term] +id: MOD:01571 +name: iTRAQ8plex-119 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01572 +name: iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" +xref: MassAvg: "432.29" +xref: MassMono: "432.294002" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01573 +name: iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "467.26" +xref: MassMono: "467.262368" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01574 +name: iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.257951" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01575 +name: iTRAQ8plex-119 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "391.23" +xref: MassMono: "391.231068" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01576 +name: iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.246718" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01577 +name: iTRAQ8plex-121 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue +is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da + +[Term] +id: MOD:01578 +name: iTRAQ8plex-121 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue +is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal + +[Term] +id: MOD:01579 +name: iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" +xref: MassAvg: "432.29" +xref: MassMono: "432.294002" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01580 +name: iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] +synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] +synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "467.26" +xref: MassMono: "467.262368" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01581 +name: iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" +xref: MassAvg: "441.26" +xref: MassMono: "441.257951" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01582 +name: iTRAQ8plex-121 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "391.23" +xref: MassMono: "391.231068" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01583 +name: iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.20" +xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" +xref: DiffMono: "304.199039" +xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" +xref: MassAvg: "405.25" +xref: MassMono: "405.246718" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue +is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue + +[Term] +id: MOD:01584 +name: modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da +def: "Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da +is_a: MOD:01592 ! modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da + +[Term] +id: MOD:01585 +name: O-glycyl-L-serine +def: "A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine." [PubMed:17502423, RESID:AA0495] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid" EXACT RESID-systematic [] +synonym: "O-(glycyl)-L-serine" EXACT RESID-name [] +synonym: "O3-(aminoacetyl)serine" EXACT RESID-alternate [] +synonym: "serine glycinate ester" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 7 N 2 O 3" +xref: MassAvg: "143.12" +xref: MassMono: "143.045667" +xref: Origin: "G, S" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00885 ! ester crosslinked residues +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:01586 +name: O-glycyl-L-threonine +def: "A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine." [PubMed:17502423, RESID:AA0496] +comment: Cross-link 2. +synonym: "(2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid" EXACT RESID-systematic [] +synonym: "O-(glycyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(2-aminoacetyl)threonine" EXACT RESID-alternate [] +synonym: "threonine glycinate ester" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 9 N 2 O 3" +xref: MassAvg: "157.15" +xref: MassMono: "157.061317" +xref: Origin: "G, T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00885 ! ester crosslinked residues +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:01587 +name: O-(2-aminoethylphosphoryl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine." [PubMed:15249686, PubMed:16825186, PubMed:16949362, RESID:AA0497] +synonym: "(2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES O-(2-aminoethylphosphoryl)serine" EXACT UniProt-feature [] +synonym: "O-(2-aminoethylphosphoryl)-L-serine" EXACT RESID-name [] +synonym: "O3-(2-aminoethylphosphoryl)-L-serine" EXACT RESID-alternate [] +synonym: "O3-(phosphoethanolamine)-L-serine" EXACT RESID-alternate [] +synonym: "serine ethanolamine phosphate" EXACT RESID-alternate [] +synonym: "serine ethanolamine phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "123.05" +xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" +xref: DiffMono: "123.008530" +xref: Formula: "C 5 H 11 N 2 O 5 P 1" +xref: MassAvg: "210.13" +xref: MassMono: "210.040558" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01588 +name: O-cholinephosphoryl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine." [PubMed:15249686, PubMed:16825186, PubMed:16949362, RESID:AA0498] +synonym: "2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium" EXACT RESID-systematic [] +synonym: "2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium" EXACT RESID-alternate [] +synonym: "MOD_RES O-(2-cholinephosphoryl)serine" EXACT UniProt-feature [] +synonym: "O-cholinephosphoryl-L-serine" EXACT RESID-name [] +synonym: "O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine" EXACT RESID-alternate [] +synonym: "O3-phosphocholine-L-serine" EXACT RESID-alternate [] +synonym: "serine choline phosphate" EXACT RESID-alternate [] +synonym: "serine choline phosphodiester" EXACT RESID-alternate [] +xref: DiffAvg: "166.14" +xref: DiffFormula: "C 5 H 13 N 1 O 3 P 1" +xref: DiffMono: "166.062756" +xref: FormalCharge: "1+" +xref: Formula: "C 8 H 18 N 2 O 5 P 1" +xref: MassAvg: "253.21" +xref: MassMono: "253.094785" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01589 +name: O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine." [PubMed:15249686, PubMed:16949362, RESID:AA0499] +synonym: "(2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic [] +synonym: "DADDGlc" EXACT RESID-alternate [] +synonym: "O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine" EXACT RESID-name [] +synonym: "O-[2,4-bis(acetylamino)]glucosyl-L-serine" EXACT RESID-alternate [] +synonym: "O-seryl-beta-2,4-bis(acetylamino)glucoside" EXACT RESID-alternate [] +synonym: "O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] +xref: DiffAvg: "244.25" +xref: DiffFormula: "C 10 H 16 N 2 O 5" +xref: DiffMono: "244.105922" +xref: Formula: "C 13 H 21 N 3 O 7" +xref: MassAvg: "331.33" +xref: MassMono: "331.137950" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:01590 +name: 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan." [ChEBI:52950, PubMed:18323630, RESID:AA0500] +synonym: "(2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan" EXACT RESID-name [] +synonym: "LIPID 3'-farnesyl-2',N2-cyclotryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "204.36" +xref: DiffFormula: "C 15 H 24 N 0 O 0" +xref: DiffMono: "204.187801" +xref: Formula: "C 26 H 34 N 2 O 1" +xref: MassAvg: "390.57" +xref: MassMono: "390.267114" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00437 ! farnesylated residue +is_a: MOD:00601 ! cyclized residue +is_a: MOD:01115 ! isoprenylated tryptophan + +[Term] +id: MOD:01591 +name: modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da +def: "Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da +is_a: MOD:01592 ! modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da + +[Term] +id: MOD:01592 +name: modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da +def: "Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da + +[Term] +id: MOD:01593 +name: iTRAQ8plex reporter fragment +def: "A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +is_a: MOD:01520 ! modification reporter fragment + +[Term] +id: MOD:01594 +name: iTRAQ8plex-113 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 6 H 13 (14)N 2" +xref: MassAvg: "113.11" +xref: MassMono: "113.107325" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue + +[Term] +id: MOD:01595 +name: iTRAQ8plex-114 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 2" +xref: MassAvg: "114.11" +xref: MassMono: "114.110680" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue + +[Term] +id: MOD:01596 +name: iTRAQ8plex-115 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1" +xref: MassAvg: "115.11" +xref: MassMono: "115.107715" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue + +[Term] +id: MOD:01597 +name: iTRAQ8plex-116 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1" +xref: MassAvg: "116.11" +xref: MassMono: "116.111069" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue + +[Term] +id: MOD:01598 +name: iTRAQ8plex-117 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1" +xref: MassAvg: "117.11" +xref: MassMono: "117.114424" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue + +[Term] +id: MOD:01599 +name: iTRAQ8plex-118 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 3 (13)C 3 H 13 (15)N 2" +xref: MassAvg: "118.11" +xref: MassMono: "118.111459" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue + +[Term] +id: MOD:01600 +name: iTRAQ8plex-119 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 2 (13)C 4 H 13 (15)N 2" +xref: MassAvg: "119.11" +xref: MassMono: "119.114814" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue + +[Term] +id: MOD:01601 +name: iTRAQ8plex-121 reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(13)C 6 H 13 (15)N 2" +xref: MassAvg: "121.12" +xref: MassMono: "121.121524" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01593 ! iTRAQ8plex reporter fragment +relationship: derives_from MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue + +[Term] +id: MOD:01602 +name: S-(L-lysyl)-L-methionine sulfilimine +def: "A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine." [PubMed:12011424, PubMed:15951440, PubMed:19729652, RESID:AA0501] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "(E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine" EXACT RESID-alternate [] +synonym: "S-(L-lysyl)-L-methionine sulfilimine" EXACT RESID-name [] +synonym: "S-lysyl-methionine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 11 H 19 N 3 O 2 S 1" +xref: MassAvg: "257.35" +xref: MassMono: "257.119798" +xref: Origin: "K, M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:01603 +name: 2x(15)N labeled L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine." [PubMed:18688235, URL:http\://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=609021|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000] +subset: PSI-MOD-slim +xref: DiffAvg: "1.99" +xref: DiffFormula: "(14)N -2 (15)N 2" +xref: DiffMono: "1.994070" +xref: Formula: "C 6 H 12 (15)N 2 O 1" +xref: MassAvg: "130.09" +xref: MassMono: "130.089033" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00843 ! (15)N labeled residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01604 +name: 4x(15)N labeled L-arginine +def: "A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine." [PubMed:18688235, URL:http\://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=600113|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000] +subset: PSI-MOD-slim +xref: DiffAvg: "3.99" +xref: DiffFormula: "(14)N -4 (15)N 4" +xref: DiffMono: "3.988140" +xref: Formula: "C 6 H 12 (15)N 4 O 1" +xref: MassAvg: "160.09" +xref: MassMono: "160.089251" +xref: Origin: "R" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00843 ! (15)N labeled residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:01605 +name: 5-glutamyl 2-aminoadipic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid." [PubMed:19620981, RESID:AA0502] +synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid" EXACT RESID-systematic [] +synonym: "5-glutamyl 2-aminoadipic acid" EXACT RESID-name [] +synonym: "MOD_RES 5-glutamyl 2-aminoadipic acid" EXACT UniProt-feature [] +synonym: "N2-(gamma-glutamyl)-2-aminoadipic acid" EXACT RESID-alternate [] +synonym: "N2-(isoglutamyl)-2-aminoadipic acid" EXACT RESID-alternate [] +xref: DiffAvg: "143.14" +xref: DiffFormula: "C 6 H 9 N 1 O 3" +xref: DiffMono: "143.058243" +xref: Formula: "C 11 H 16 N 2 O 6" +xref: MassAvg: "272.26" +xref: MassMono: "272.100836" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00674 ! amidated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01606 +name: 5-glutamyl 2-aminoadipic 6-phosphoric anhydride +def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride." [PubMed:19620981, RESID:AA0503] +synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid" EXACT RESID-systematic [] +synonym: "5-glutamyl 2-aminoadipic 6-phosphoric anhydride" EXACT RESID-name [] +xref: DiffAvg: "223.12" +xref: DiffFormula: "C 6 H 10 N 1 O 6 P 1" +xref: DiffMono: "223.024574" +xref: Formula: "C 11 H 17 N 2 O 9 P 1" +xref: MassAvg: "352.24" +xref: MassMono: "352.067167" +xref: Origin: "E" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00674 ! amidated residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01607 +name: 5-glutamyl allysine +def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine." [PubMed:19620981, RESID:AA0504] +synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid" EXACT RESID-systematic [] +synonym: "2-(5-glutamyl)amino-6-oxohexanoic acid" EXACT RESID-alternate [] +synonym: "5-glutamyl allysine" EXACT RESID-name [] +synonym: "alpha-(gamma-glutamyl)allysine" EXACT RESID-alternate [] +synonym: "N2-(gamma-glutamyl)allysine" EXACT RESID-alternate [] +synonym: "N2-(isoglutamyl)allysine" EXACT RESID-alternate [] +xref: DiffAvg: "127.14" +xref: DiffFormula: "C 6 H 9 N 1 O 2" +xref: DiffMono: "127.063329" +xref: Formula: "C 11 H 16 N 2 O 5" +xref: MassAvg: "256.26" +xref: MassMono: "256.105922" +xref: Origin: "E" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00674 ! amidated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01608 +name: N2-(L-isoglutamyl)-L-lysine +def: "A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link." [PubMed:19620981, RESID:AA0505] +synonym: "(2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "5-glutamyl N2-lysine" EXACT RESID-alternate [] +synonym: "alpha-(gamma-glutamyl)lysine" EXACT RESID-alternate [] +synonym: "gamma-glutamyl N2-lysine" EXACT RESID-alternate [] +synonym: "MOD_RES 5-glutamyl N2-lysine" EXACT UniProt-feature [] +synonym: "N2-(gamma-glutamyl)lysine" EXACT RESID-alternate [] +synonym: "N2-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "128.18" +xref: DiffFormula: "C 6 H 12 N 2 O 1" +xref: DiffMono: "128.094963" +xref: Formula: "C 11 H 19 N 3 O 4" +xref: MassAvg: "257.29" +xref: MassMono: "257.137556" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01609 +name: 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan." [PubMed:19584055, RESID:AA0506] +synonym: "(2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid" EXACT RESID-systematic [] +synonym: "7'-hydroxy-2'-alpha-mannosyl-L-tryptophan" EXACT RESID-name [] +synonym: "MOD_RES 7'-hydroxytryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "178.14" +xref: DiffFormula: "C 6 H 10 N 0 O 6" +xref: DiffMono: "178.047738" +xref: Formula: "C 17 H 20 N 2 O 7" +xref: MassAvg: "364.35" +xref: MassMono: "364.127051" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue +relationship: has_functional_parent MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan +relationship: has_functional_parent MOD:01664 ! 7'-hydroxy-L-tryptophan + +[Term] +id: MOD:01610 +name: L-threonine methyl ester +def: "A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester." [PubMed:19745839, RESID:AA0507] +synonym: "L-threonine methyl ester" EXACT RESID-name [] +synonym: "methyl (2S,3R)-2-amino-3-hydroxybutanoate" EXACT RESID-systematic [] +synonym: "methyl L-threoninate" EXACT RESID-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 5 H 10 N 1 O 3" +xref: MassAvg: "132.14" +xref: MassMono: "132.066068" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01689 ! alpha-carboxyl methylated residue +is_a: MOD:01803 ! O-methylated threonine + +[Term] +id: MOD:01611 +name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN +def: "A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN." [PubMed:17935335, RESID:AA0508] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate" EXACT RESID-systematic [] +synonym: "6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN" EXACT RESID-alternate [] +synonym: "6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN" EXACT RESID-alternate [] +synonym: "6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN" EXACT RESID-alternate [] +synonym: "6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN" EXACT RESID-alternate [] +synonym: "6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN" EXACT RESID-name [] +synonym: "BINDING FMN (covalent; via 2 links)" EXACT UniProt-feature [] +synonym: "BINDING FMN (covalent; via 2 links, pros nitrogen)" EXACT UniProt-feature [] +xref: DiffAvg: "452.32" +xref: DiffFormula: "C 17 H 17 N 4 O 9 P 1 S 0" +xref: DiffMono: "452.073315" +xref: Formula: "C 26 H 29 N 8 O 11 P 1 S 1" +xref: MassAvg: "692.60" +xref: MassMono: "692.141411" +xref: Origin: "C, H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00896 ! FMN modified residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01621 ! flavin crosslinked residues + +[Term] +id: MOD:01612 +name: 3'-iodo-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine." [ChEBI:27847, PubMed:8995307, RESID:AA0509] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3'-iodo-L-tyrosine" EXACT RESID-name [] +synonym: "3-iodo-L-tyrosine" EXACT RESID-alternate [] +synonym: "3-iodotyrosine" EXACT RESID-alternate [] +synonym: "4-hydroxy-3-iodo-phenylalanine" EXACT RESID-alternate [] +synonym: "MIT" EXACT RESID-alternate [] +synonym: "MOD_RES Iodotyrosine" EXACT UniProt-feature [] +xref: DiffAvg: "125.90" +xref: DiffFormula: "C 0 H -1 I 1 N 0 O 0" +xref: DiffMono: "125.896648" +xref: Formula: "C 9 H 8 I 1 N 1 O 2" +xref: MassAvg: "289.07" +xref: MassMono: "288.959976" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01228 ! monoiodinated tyrosine + +[Term] +id: MOD:01613 +name: 3',5'-diiodo-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine." [ChEBI:15768, PubMed:8995307, RESID:AA0510] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3',5'-diiodo-L-tyrosine" EXACT RESID-name [] +synonym: "3,5-diiodo-L-tyrosine" EXACT RESID-alternate [] +synonym: "3,5-diiodotyrosine" EXACT RESID-alternate [] +synonym: "DIT" EXACT RESID-alternate [] +synonym: "iodogorgoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES Diiodotyrosine" EXACT UniProt-feature [] +xref: DiffAvg: "251.79" +xref: DiffFormula: "C 0 H -2 I 2 N 0 O 0" +xref: DiffMono: "251.793295" +xref: Formula: "C 9 H 7 I 2 N 1 O 2" +xref: MassAvg: "414.97" +xref: MassMono: "414.856624" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01140 ! diiodinated tyrosine + +[Term] +id: MOD:01614 +name: glycyl phospho-5'-adenosine +def: "A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine." [PubMed:16388576, PubMed:9632726, RESID:AA0511] +synonym: "(2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid" EXACT RESID-alternate [] +synonym: "([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate" EXACT RESID-alternate [] +synonym: "5'-adenylic-glyinate" EXACT RESID-alternate [] +synonym: "aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate" EXACT RESID-systematic [] +synonym: "glycine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] +synonym: "glycyl 5'-adenylate" EXACT RESID-alternate [] +synonym: "glycyl adenosine-5'-phosphate" EXACT RESID-alternate [] +synonym: "glycyl phospho-5'-adenosine" EXACT RESID-name [] +synonym: "glycyladenylate" EXACT RESID-alternate [] +synonym: "MOD_RES Glycyl adenylate" EXACT UniProt-feature [] +xref: DiffAvg: "329.21" +xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" +xref: DiffMono: "329.052520" +xref: Formula: "C 12 H 16 N 6 O 8 P 1" +xref: MassAvg: "403.27" +xref: MassMono: "403.076723" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01165 ! adenylated residue + +[Term] +id: MOD:01615 +name: glycyl cysteine dithioester +def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester." [PubMed:11438688, PubMed:16388576, RESID:AA0512] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid" EXACT RESID-systematic [] +synonym: "2-(glycyldithio)alanine" EXACT RESID-alternate [] +synonym: "glycyl cysteine dithioester" EXACT RESID-name [] +synonym: "S-glycyl cysteine persulfide" EXACT RESID-alternate [] +synonym: "S-glycyl thiocysteine" EXACT RESID-alternate [] +synonym: "thioglycine cysteine disulfide" EXACT RESID-alternate [] +xref: DiffAvg: "14.05" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 1" +xref: DiffMono: "13.961506" +xref: Formula: "C 5 H 7 N 2 O 2 S 2" +xref: MassAvg: "191.24" +xref: MassMono: "190.994894" +xref: Origin: "C, G" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00395 ! thioester crosslinked residues +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:00954 ! crosslinked residues with loss of water + +[Term] +id: MOD:01616 +name: trithiocystine +def: "A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine." [PubMed:19438211, RESID:AA0513] +comment: Cross-link 2. +synonym: "(2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "3,3'-pentathiobisalanine" EXACT RESID-alternate [] +synonym: "bis(2-amino-2-carboxyethyl)pentasulfide" EXACT RESID-alternate [] +synonym: "trithiocystine" EXACT RESID-name [] +xref: DiffAvg: "94.16" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 3" +xref: DiffMono: "93.900563" +xref: Formula: "C 6 H 8 N 2 O 2 S 5" +xref: MassAvg: "300.44" +xref: MassMono: "299.918933" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01620 ! polysulfide crosslinked residues + +[Term] +id: MOD:01617 +name: O-(6-phosphomannosyl)-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine." [PubMed:20044576, RESID:AA0514] +synonym: "(2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid" EXACT RESID-systematic [] +synonym: "O-(6-phosphomannosyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(6-phosphomannosyl)threonine" EXACT RESID-alternate [] +xref: DiffAvg: "242.12" +xref: DiffFormula: "C 6 H 11 N 0 O 8 P 1" +xref: DiffMono: "242.019154" +xref: Formula: "C 10 H 18 N 1 O 10 P 1" +xref: MassAvg: "343.22" +xref: MassMono: "343.066832" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00005 ! O-glycosyl-L-threonine +is_a: MOD:00595 ! mannosylated residue + +[Term] +id: MOD:01618 +name: L-alanyl-L-isoaspartyl cyclopeptide +def: "A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide." [PubMed:19928958, PubMed:3207697, RESID:AA0515] +comment: Cross-link 2. +synonym: "(2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid" EXACT RESID-systematic [] +synonym: "1,4.2-anhydro(L-alanyl-L-aspartic acid)" EXACT RESID-alternate [] +synonym: "CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn)" EXACT UniProt-feature [] +synonym: "L-alanyl-L-isoaspartyl cyclopeptide" EXACT RESID-name [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 7 H 9 N 2 O 3" +xref: MassAvg: "169.16" +xref: MassMono: "169.061317" +xref: Origin: "A, N" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia + +[Term] +id: MOD:01619 +name: multisulfide crosslinked residues +def: "A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01620 +name: polysulfide crosslinked residues +def: "A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms." [PubMed:18688235] +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:01619 ! multisulfide crosslinked residues + +[Term] +id: MOD:01621 +name: flavin crosslinked residues +def: "A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00697 ! flavin modified residue + +[Term] +id: MOD:01622 +name: monohydroxylated tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan." [OMSSA:90, UniMod:35#W] +synonym: "Oxidation" RELATED PSI-MS-label [] +synonym: "oxyw" EXACT OMSSA-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 11 H 10 N 2 O 2" +xref: MassAvg: "202.21" +xref: MassMono: "202.074228" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01623 +name: 1-thioglycine (C-terminal) +def: "A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine." [PubMed:11463785, PubMed:19145231, PubMed:9367957, RESID:AA0265#var] +subset: PSI-MOD-slim +xref: DiffAvg: "16.06" +xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1" +xref: DiffMono: "15.977156" +xref: Formula: "C 2 H 3 N 1 S 1" +xref: MassAvg: "73.11" +xref: MassMono: "72.998620" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01625 ! 1-thioglycine + +[Term] +id: MOD:01624 +name: (2-aminosuccinimidyl)acetic acid (Asn) +def: "A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia." [PubMed:10801322, PubMed:2015294, RESID:AA0441#ASN] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "(2-aminosuccinimidyl)acetic acid" EXACT RESID-name [] +synonym: "(3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid" EXACT RESID-alternate [] +synonym: "[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid" EXACT RESID-systematic [] +synonym: "anhydroaspartyl glycine" EXACT RESID-alternate [] +synonym: "aspartimide glycine" EXACT RESID-alternate [] +synonym: "CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly)" EXACT UniProt-feature [] +synonym: "N-(2-aminosuccinyl)glycine" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 6 H 6 N 2 O 3" +xref: MassAvg: "154.13" +xref: MassMono: "154.037842" +xref: Origin: "G, N" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia +is_a: MOD:01628 ! (2-aminosuccinimidyl)acetic acid + +[Term] +id: MOD:01625 +name: 1-thioglycine +def: "A protein modification that effectively converts a glycine residue to 1-thioglycine." [PubMed:11463785, PubMed:9367957, RESID:AA0265] +comment: This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG]. +subset: PSI-MOD-slim +synonym: "1-thioglycine" EXACT RESID-name [] +synonym: "2-amino-1-sulfanylethanone" EXACT RESID-alternate [] +synonym: "aminoethanethioic acid" EXACT RESID-systematic [] +synonym: "aminothioacetic acid" EXACT RESID-alternate [] +synonym: "Carboxy->Thiocarboxy" RELATED PSI-MS-label [] +synonym: "MOD_RES 1-thioglycine" EXACT UniProt-feature [] +synonym: "S(O)Gly" EXACT PSI-MOD-label [] +synonym: "thiocarboxylic acid" RELATED UniMod-description [] +xref: DiffAvg: "16.06" +xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1" +xref: DiffMono: "15.977156" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "G" +xref: Source: "natural" +is_a: MOD:00749 ! sulfur substitution for oxygen +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:01626 +name: L-cystine +def: "A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine." [ChEBI:16283, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025] +comment: This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765). +subset: PSI-MOD-slim +synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer [] +synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate [] +synonym: "3,3'-dithiodialanine" EXACT RESID-alternate [] +synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate [] +synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate [] +synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate [] +synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate [] +synonym: "Cys2" EXACT PSI-MOD-label [] +synonym: "Cystine ((Cys)2)" EXACT DeltaMass-label [] +synonym: "dicysteine" EXACT RESID-alternate [] +synonym: "L-cystine" EXACT RESID-name [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "none" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01627 +name: L-cysteinyl-L-selenocysteine +def: "A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine." [PubMed:12911312, PubMed:18688235] +comment: Cross-link 2. +subset: PSI-MOD-slim +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1" +xref: MassAvg: "251.17" +xref: MassMono: "251.947170" +xref: Origin: "C, X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01628 +name: (2-aminosuccinimidyl)acetic acid +def: "A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue." [PubMed:10801322, PubMed:18688235] +comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. +subset: PSI-MOD-slim +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 6 N 2 O 3" +xref: MassAvg: "154.13" +xref: MassMono: "154.037842" +xref: Origin: "G, X" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues + +[Term] +id: MOD:01629 +name: cyclo[(prolylserin)-O-yl] cysteinate +def: "A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue." [PubMed:7961166, RESID:AA0489] +synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate [] +synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] +synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name [] +synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 11 H 16 N 3 O 4 S 1" +xref: MassAvg: "286.33" +xref: MassMono: "286.086152" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01630 +name: N6-(L-isoglutamyl)-L-lysine +def: "A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine ." [ChEBI:21863, DeltaMass:0, PubMed:2461365, PubMed:5637041, PubMed:5656070, PubMed:8598899, RESID:AA0124] +comment: Cross-link 2. +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate [] +synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate [] +synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label [] +synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate [] +synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 11 H 17 N 3 O 3" +xref: MassAvg: "239.27" +xref: MassMono: "239.126991" +xref: Origin: "K, X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01631 +name: L-alanine removal +def: "A protein modification that effectively removes or replaces an L-alanine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-71.08" +xref: DiffFormula: "C -3 H -5 N -1 O -1" +xref: DiffMono: "-71.037114" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01632 +name: L-arginine removal +def: "A protein modification that effectively removes or replaces an L-arginine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-156.19" +xref: DiffFormula: "C -6 H -12 N -4 O -1" +xref: DiffMono: "-156.101111" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01633 +name: L-asparagine removal +def: "A protein modification that effectively removes or replaces an L-asparagine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-114.10" +xref: DiffFormula: "C -4 H -6 N -2 O -2" +xref: DiffMono: "-114.042927" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01634 +name: L-aspartic acid removal +def: "A protein modification that effectively removes or replaces an L-aspartic acid." [PubMed:18688235] +comment: This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-115.09" +xref: DiffFormula: "C -4 H -5 N -1 O -3" +xref: DiffMono: "-115.026943" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01635 +name: L-cysteine removal +def: "A protein modification that effectively removes or replaces an L-cysteine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-103.14" +xref: DiffFormula: "C -3 H -5 N -1 O -1 S -1" +xref: DiffMono: "-103.009185" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01636 +name: L-glutamic acid removal +def: "A protein modification that effectively removes or replaces an L-glutamic acid." [PubMed:18688235] +comment: This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-129.12" +xref: DiffFormula: "C -5 H -7 N -1 O -3" +xref: DiffMono: "-129.042593" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01637 +name: L-glutamine removal +def: "A protein modification that effectively removes or replaces an L-glutamine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-128.13" +xref: DiffFormula: "C -5 H -8 N -2 O -2" +xref: DiffMono: "-128.058578" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01638 +name: glycine removal +def: "A protein modification that effectively removes or replaces a glycine." [PubMed:18688235] +comment: This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-57.05" +xref: DiffFormula: "C -2 H -3 N -1 O -1" +xref: DiffMono: "-57.021464" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01639 +name: L-histidine removal +def: "A protein modification that effectively removes or replaces an L-histidine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-137.14" +xref: DiffFormula: "C -6 H -7 N -3 O -1" +xref: DiffMono: "-137.058912" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01640 +name: L-isoleucine removal +def: "A protein modification that effectively removes or replaces an L-isoleucine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-113.16" +xref: DiffFormula: "C -6 H -11 N -1 O -1" +xref: DiffMono: "-113.084064" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01641 +name: L-leucine removal +def: "A protein modification that effectively removes or replaces an L-leucine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-113.16" +xref: DiffFormula: "C -6 H -11 N -1 O -1" +xref: DiffMono: "-113.084064" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "L" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00911 ! modified L-leucine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01642 +name: L-lysine removal +def: "A protein modification that effectively removes or replaces an L-lysine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-128.18" +xref: DiffFormula: "C -6 H -12 N -2 O -1" +xref: DiffMono: "-128.094963" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01643 +name: L-methionine removal +def: "A protein modification that effectively removes or replaces an L-methionine." [OMSSA:9, PubMed:3327521, UniMod:765] +comment: This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG]. +subset: PSI-MOD-slim +synonym: "Met-loss" RELATED UniMod-interim [] +synonym: "ntermmcleave" EXACT OMSSA-label [] +xref: DiffAvg: "-131.19" +xref: DiffFormula: "C -5 H -9 N -1 O -1 S -1" +xref: DiffMono: "-131.040485" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01644 +name: L-phenylalanine removal +def: "A protein modification that effectively removes or replaces an L-phenylalanine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-147.18" +xref: DiffFormula: "C -9 H -9 N -1 O -1" +xref: DiffMono: "-147.068414" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "F" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01645 +name: L-proline removal +def: "A protein modification that effectively removes or replaces an L-proline." [PubMed:18688235] +comment: This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-97.12" +xref: DiffFormula: "C -5 H -7 N -1 O -1" +xref: DiffMono: "-97.052764" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01646 +name: L-serine removal +def: "A protein modification that effectively removes or replaces an L-serine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-87.08" +xref: DiffFormula: "C -3 H -5 N -1 O -2" +xref: DiffMono: "-87.032028" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01647 +name: L-threonine removal +def: "A protein modification that effectively removes or replaces an L-threonine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-101.10" +xref: DiffFormula: "C -4 H -7 N -1 O -2" +xref: DiffMono: "-101.047678" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01648 +name: L-tryptophan removal +def: "A protein modification that effectively removes or replaces an L-tryptophan." [PubMed:18688235] +comment: This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-186.21" +xref: DiffFormula: "C -11 H -10 N -2 O -1" +xref: DiffMono: "-186.079313" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00918 ! modified L-tryptophan residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01649 +name: L-tyrosine removal +def: "A protein modification that effectively removes or replaces an L-tyrosine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-163.18" +xref: DiffFormula: "C -9 H -9 N -1 O -2" +xref: DiffMono: "-163.063329" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01650 +name: L-valine removal +def: "A protein modification that effectively removes or replaces an L-valine." [PubMed:18688235] +comment: This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: DiffAvg: "-99.13" +xref: DiffFormula: "C -5 H -9 N -1 O -1" +xref: DiffMono: "-99.068414" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01651 ! natural, standard, encoded residue removal + +[Term] +id: MOD:01651 +name: natural, standard, encoded residue removal +def: "A protein modification that effectively removes or replaces a natural, standard, encoded residue." [PubMed:18688235] +comment: This represents the loss or replacement of an encoded residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00009 ! natural residue + +[Term] +id: MOD:01652 +name: sulfonyl halide reagent derivatized residue +def: "A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent." [PubMed:18688235] +comment: These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide. +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01653 +name: dansyl chloride derivatized residue +def: "A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride." [DeltaMass:0, UniMod:139] +synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] +synonym: "Dansyl" RELATED PSI-MS-label [] +synonym: "Dansyl (Dns)" EXACT DeltaMass-label [] +synonym: "DansylRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "233.29" +xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" +xref: DiffMono: "233.051050" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue + +[Term] +id: MOD:01654 +name: N6-Dansyl derivatized lysine +def: "A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine." [UniMod:139#K] +synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] +synonym: "Dansyl" RELATED PSI-MS-label [] +synonym: "N6DansylLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "233.29" +xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" +xref: DiffMono: "233.051050" +xref: Formula: "C 18 H 23 N 3 O 3 S 1" +xref: MassAvg: "361.46" +xref: MassMono: "361.146013" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01653 ! dansyl chloride derivatized residue + +[Term] +id: MOD:01655 +name: alpha-amino-Dansyl derivatized residue +def: "A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue." [UniMod:139#N-term] +synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] +synonym: "Dansyl" RELATED PSI-MS-label [] +synonym: "N2DansylRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "233.29" +xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" +xref: DiffMono: "233.051050" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01653 ! dansyl chloride derivatized residue + +[Term] +id: MOD:01656 +name: Dabsyl chloride derivatized residue +def: "A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride." [PubMed:18688235] +synonym: "4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl" EXACT PSI-MOD-alternate [] +synonym: "DabsylRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "287.34" +xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1" +xref: DiffMono: "287.072848" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue + +[Term] +id: MOD:01657 +name: N6-Dabsyl derivatized lysine +def: "A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine." [PubMed:18688235] +synonym: "N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine" EXACT PSI-MOD-alternate [] +synonym: "N6DabsylLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "287.34" +xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1" +xref: DiffMono: "287.072848" +xref: Formula: "C 20 H 25 N 5 O 3 S 1" +xref: MassAvg: "415.51" +xref: MassMono: "415.167811" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01656 ! Dabsyl chloride derivatized residue + +[Term] +id: MOD:01658 +name: alpha-amino-Dabsyl derivatized residue +def: "A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue." [PubMed:18688235] +synonym: "N2DabsylRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "287.34" +xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1" +xref: DiffMono: "287.072848" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01656 ! Dabsyl chloride derivatized residue + +[Term] +id: MOD:01659 +name: Uniblue A derivatized residue +def: "A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A." [PubMed:18688235] +comment: This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues. +synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid" EXACT PSI-MOD-alternate [] +synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid" EXACT PSI-MOD-alternate [] +synonym: "Uniblue A" EXACT PSI-MOD-alternate [] +synonym: "UniblueARes" EXACT PSI-MOD-label [] +xref: DiffAvg: "484.50" +xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2" +xref: DiffMono: "484.039893" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01660 +name: Uniblue A derivatized cysteine +def: "A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] +synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] +synonym: "SUniblueACys" EXACT PSI-MOD-label [] +synonym: "Uniblue A" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "484.50" +xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2" +xref: DiffMono: "484.039893" +xref: Formula: "C 25 H 21 N 3 O 8 S 3" +xref: MassAvg: "587.64" +xref: MassMono: "587.049078" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01659 ! Uniblue A derivatized residue + +[Term] +id: MOD:01661 +name: pyruvic acid (Tyr) +def: "A protein modification that effectively converts an L-tyrosine residue to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:500639, PubMed:8464063, RESID:AA0127#TYR] +synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES Pyruvic acid (Tyr)" EXACT UniProt-feature [] +synonym: "pyruvic acid" EXACT RESID-name [] +xref: DiffAvg: "-93.13" +xref: DiffFormula: "C -6 H -7 N -1 O 0" +xref: DiffMono: "-93.057849" +xref: Formula: "C 3 H 3 O 2" +xref: MassAvg: "71.06" +xref: MassMono: "71.013304" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01154 ! pyruvic acid + +[Term] +id: MOD:01662 +name: N5-(ADP-ribosyl)-L-glutamine +def: "A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine." [PubMed:20185726, RESID:AA0518] +synonym: "(S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "N5-(ADP-ribosyl)-L-glutamine" EXACT RESID-name [] +synonym: "N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine" EXACT RESID-alternate [] +synonym: "N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 20 H 29 N 7 O 15 P 2" +xref: MassAvg: "669.43" +xref: MassMono: "669.119687" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:01663 +name: O-(ADP-ribosyl)-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine." [PubMed:20185726, RESID:AA0519] +synonym: "(S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid" EXACT RESID-systematic [] +synonym: "O-(ADP-ribosyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(ADP-ribosyl)-L-threonine" EXACT RESID-alternate [] +synonym: "O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine" EXACT RESID-alternate [] +synonym: "O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] +xref: DiffAvg: "541.30" +xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" +xref: DiffMono: "541.061109" +xref: Formula: "C 19 H 28 N 6 O 15 P 2" +xref: MassAvg: "642.41" +xref: MassMono: "642.108787" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01664 +name: 7'-hydroxy-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan." [PubMed:20223990, RESID:AA0520] +synonym: "(2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "7'-hydroxy-L-tryptophan" EXACT RESID-name [] +synonym: "7-hydroxy-L-tryptophan" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 11 H 10 N 2 O 2" +xref: MassAvg: "202.21" +xref: MassMono: "202.074228" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01622 ! monohydroxylated tryptophan + +[Term] +id: MOD:01665 +name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine +def: "A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine." [PubMed:20185759, RESID:AA0521] +synonym: "(2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen" EXACT UniProt-feature [] +synonym: "DNA glycosylase valine Schiff base intermediate" EXACT RESID-alternate [] +synonym: "N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine" EXACT RESID-name [] +xref: DiffAvg: "178.08" +xref: DiffFormula: "C 5 H 7 N 0 O 5 P 1" +xref: DiffMono: "178.003110" +xref: Formula: "C 10 H 17 N 1 O 6 P 1" +xref: MassAvg: "278.22" +xref: MassMono: "278.079349" +xref: Origin: "V" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00750 ! deoxyribonucleic acid linked residue +is_a: MOD:00920 ! modified L-valine residue + +[Term] +id: MOD:01666 +name: epicocconone derivatized residue +def: "A protein modification that is produced by formation of an adduct with epicocconone." [PubMed:18688235] +synonym: "(6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione" EXACT PSI-MOD-alternate [] +synonym: "Deep Purple" EXACT PSI-MOD-alternate [] +synonym: "LavaPurple" EXACT PSI-MOD-alternate [] +synonym: "Lightning Fast" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "410.42" +xref: DiffFormula: "C 23 H 22 O 7" +xref: DiffMono: "410.136553" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01667 +name: N6-epicoccononyl lysine adduct +def: "A protein modification that is produced by formation of an adduct with epicocconone." [PubMed:18688235] +synonym: "(6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione" EXACT PSI-MOD-alternate [] +synonym: "DeepPurple" EXACT PSI-MOD-alternate [] +synonym: "LavaPurple" EXACT PSI-MOD-alternate [] +synonym: "Lightning Fast" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "410.42" +xref: DiffFormula: "C 23 H 22 O 7" +xref: DiffMono: "410.136553" +xref: Formula: "C 29 H 34 N 2 O 8" +xref: MassAvg: "538.60" +xref: MassMono: "538.231516" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01666 ! epicocconone derivatized residue + +[Term] +id: MOD:01668 +name: O4-(8alpha-FAD)-L-aspartate +def: "A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate." [PubMed:20080101, RESID:AA0522] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid" EXACT RESID-systematic [] +synonym: "8alpha-[(4-aspartyl)oxy]FAD" EXACT RESID-alternate [] +synonym: "O4-(8alpha-FAD)-L-aspartate" EXACT RESID-name [] +xref: DiffAvg: "783.54" +xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" +xref: DiffMono: "783.141485" +xref: Formula: "C 31 H 36 N 10 O 18 P 2" +xref: MassAvg: "898.63" +xref: MassMono: "898.168428" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00895 ! FAD modified residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01669 +name: trimethyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine." [OMSSA:117, PubMed:11704273, PubMed:602668, RESID:AA0523, UniMod:37#R] +synonym: "(2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid" EXACT RESID-alternate [] +synonym: "2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine" EXACT RESID-alternate [] +synonym: "N(G)-trimethylarginine" EXACT RESID-alternate [] +synonym: "N5-[(dimethylamino)(imino)methyl]ornithine" EXACT RESID-alternate [] +synonym: "NoNoNo'Me3Arg" EXACT PSI-MOD-label [] +synonym: "omega-N,omega-N,omega-N'-trimethyl-L-arginine" EXACT RESID-name [] +synonym: "tri-Methylation" RELATED UniMod-description [] +synonym: "Trimethyl" RELATED PSI-MS-label [] +synonym: "trimethylationr" EXACT OMSSA-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0" +xref: DiffMono: "42.046950" +xref: Formula: "C 9 H 18 N 4 O 1" +xref: MassAvg: "198.27" +xref: MassMono: "198.148061" +xref: Origin: "R" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00430 ! trimethylated residue +is_a: MOD:00602 ! N-methylated residue +is_a: MOD:00658 ! methylated arginine + +[Term] +id: MOD:01670 +name: N6-chloro-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine." [PubMed:16091367, PubMed:16195462, PubMed:17260957, RESID:AA0524] +synonym: "(2S)-2-amino-6-(chloroamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "epsilon-chlorolysine" EXACT RESID-alternate [] +synonym: "lysine chloramine" EXACT RESID-alternate [] +synonym: "N(zeta)-chlorolysine" EXACT RESID-alternate [] +synonym: "N6-chloro-L-lysine" EXACT RESID-name [] +synonym: "N6ClLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 6 Cl 1 H 11 N 2 O 1" +xref: MassAvg: "162.62" +xref: MassMono: "162.055991" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01672 ! halogenated lysine +is_a: MOD:01911 ! monochlorinated residue + +[Term] +id: MOD:01671 +name: O-(L-isoaspartyl)-L-threonine (active site intermediate) +def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia." [PubMed:8706862, RESID:AA0525#THR] +comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. +synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE O-isoaspartyl threonine intermediate" EXACT UniProt-feature [] +synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate [] +xref: DiffAvg: "115.09" +xref: DiffFormula: "C 4 H 5 N 1 O 3" +xref: DiffMono: "115.026943" +xref: Formula: "C 8 H 12 N 2 O 5" +xref: MassAvg: "216.19" +xref: MassMono: "216.074621" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00671 ! O-acylated residue +is_a: MOD:01978 ! O-(L-isoaspartyl)-L-threonine + +[Term] +id: MOD:01672 +name: halogenated lysine +def: "A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom." [PubMed:18688235] +xref: Origin: "K" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00694 ! halogen containing residue + +[Term] +id: MOD:01673 +name: N-acetylaminohexosylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond." [UniMod:43] +subset: PSI-MOD-slim +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "HexNAcRes" EXACT PSI-MOD-label [] +synonym: "N-Acetylhexosamine" RELATED UniMod-description [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00436 ! N-acetylhexosaminylated + +[Term] +id: MOD:01674 +name: N4-(N-acetylamino)hexosyl-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine." [OMSSA:182, UniMod:43#N] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid" EXACT PSI-MOD-alternate [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "HexNAcAsn" EXACT PSI-MOD-label [] +synonym: "hexNAcN" EXACT OMSSA-label [] +synonym: "N-Acetylhexosamine" RELATED UniMod-description [] +synonym: "N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "N4-(N-acetylhexosaminyl)asparagine" EXACT PSI-MOD-alternate [] +synonym: "N4-asparagine-beta-N-acetylhexosaminide" EXACT PSI-MOD-alternate [] +synonym: "N4-glycosyl-L-asparagine" EXACT PSI-MOD-alternate [] +synonym: "N4-glycosylasparagine" EXACT PSI-MOD-alternate [] +synonym: "N4HexNAcAsn" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 12 H 19 N 3 O 7" +xref: MassAvg: "317.30" +xref: MassMono: "317.122300" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00160 ! N4-glycosyl-L-asparagine +is_a: MOD:01673 ! N-acetylaminohexosylated residue + +[Term] +id: MOD:01675 +name: O-(N-acetylamino)hexosyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine." [OMSSA:184, UniMod:43#S] +subset: PSI-MOD-slim +synonym: "(S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid" EXACT PSI-MOD-alternate [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "hexNAcS" EXACT OMSSA-label [] +synonym: "N-Acetylhexosamine" RELATED UniMod-description [] +synonym: "O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine" EXACT PSI-MOD-alternate [] +synonym: "O-(N-acetylhexosaminyl)serine" EXACT PSI-MOD-alternate [] +synonym: "O-glycosylserine" EXACT PSI-MOD-alternate [] +synonym: "O-seryl-beta-N-acetylhexosaminide" EXACT PSI-MOD-alternate [] +synonym: "O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine" EXACT PSI-MOD-alternate [] +synonym: "OHexNAcSer" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 11 H 18 N 2 O 7" +xref: MassAvg: "290.27" +xref: MassMono: "290.111401" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine +is_a: MOD:01673 ! N-acetylaminohexosylated residue + +[Term] +id: MOD:01676 +name: O-(N-acetylamino)hexosyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine." [OMSSA:185, UniMod:43#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid" EXACT PSI-MOD-alternate [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "hexNAcT" EXACT OMSSA-label [] +synonym: "N-Acetylhexosamine" RELATED UniMod-description [] +synonym: "O-(N-acetylhexcosaminyl)-L-threonine" EXACT PSI-MOD-alternate [] +synonym: "O-glycosylthreonine" EXACT PSI-MOD-alternate [] +synonym: "O3-(N-acetylhexosaminyl)threonine" EXACT PSI-MOD-alternate [] +synonym: "OHexNAcThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 12 H 20 N 2 O 7" +xref: MassAvg: "304.30" +xref: MassMono: "304.127051" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00005 ! O-glycosyl-L-threonine +is_a: MOD:01673 ! N-acetylaminohexosylated residue + +[Term] +id: MOD:01677 +name: O4-(N-acetylamino)hexosyl-L-hydroxyproline +def: "A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline." [PubMed:18688235] +comment: secondary to RESID:AA0030 +subset: PSI-MOD-slim +synonym: "(2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid" EXACT PSI-MOD-alternate [] +synonym: "4-(N-acetylhexosaminyloxy)proline" EXACT PSI-MOD-alternate [] +synonym: "4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline" EXACT PSI-MOD-alternate [] +synonym: "alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline" EXACT PSI-MOD-alternate [] +synonym: "HexNAc" RELATED PSI-MS-label [] +synonym: "O4-glycosyl-hydroxyproline" EXACT PSI-MOD-alternate [] +synonym: "O4HexNAcHyPro" EXACT PSI-MOD-label [] +xref: DiffAvg: "219.19" +xref: DiffFormula: "C 8 H 13 N 1 O 6" +xref: DiffMono: "219.074287" +xref: Formula: "C 13 H 20 N 2 O 7" +xref: MassAvg: "316.31" +xref: MassMono: "316.127051" +xref: Origin: "P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01673 ! N-acetylaminohexosylated residue + +[Term] +id: MOD:01678 +name: N6-carbamoyl-L-lysine +def: "A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine." [DeltaMass:56, OMSSA:31, PubMed:10978403, PubMed:12203680, UniMod:5#K] +comment: This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG]. +subset: PSI-MOD-slim +synonym: "2-amino-6-ureido-hexanoic acid" EXACT PSI-MOD-alternate [] +synonym: "Carbamyl" RELATED UniMod-interim [] +synonym: "Carbamylation" RELATED UniMod-description [] +synonym: "carbamylk" EXACT OMSSA-label [] +synonym: "homocitrulline" EXACT PSI-MOD-alternate [] +synonym: "N6-(aminocarbonyl)-L-lysine" EXACT PSI-MOD-alternate [] +synonym: "N6CbmLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "43.02" +xref: DiffFormula: "C 1 H 1 N 1 O 1" +xref: DiffMono: "43.005814" +xref: Formula: "C 7 H 13 N 3 O 2" +xref: MassAvg: "171.20" +xref: MassMono: "171.100777" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00398 ! carbamoylated residue + +[Term] +id: MOD:01679 +name: alpha-aminocarbamoylated residue +def: "A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group." [DeltaMass:56, OMSSA:32, PubMed:10978403, PubMed:12203680, UniMod:5#N-term] +comment: This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG]. +subset: PSI-MOD-slim +synonym: "Carbamyl" RELATED UniMod-interim [] +synonym: "Carbamylation" RELATED UniMod-description [] +synonym: "N2CbmRes" EXACT PSI-MOD-label [] +synonym: "ntermcarbamyl" EXACT OMSSA-label [] +xref: DiffAvg: "43.02" +xref: DiffFormula: "C 1 H 1 N 1 O 1" +xref: DiffMono: "43.005814" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00398 ! carbamoylated residue + +[Term] +id: MOD:01680 +name: alpha-amino monomethylated residue +def: "A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group." [OMSSA:11, OMSSA:76, UniMod:34#N-term] +comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. +subset: PSI-MOD-slim +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "N2Me1Res" EXACT PSI-MOD-label [] +synonym: "ntermmethyl" EXACT OMSSA-label [] +synonym: "ntermpepmethyl" EXACT OMSSA-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01681 +name: monomethylated L-aspartic acid +def: "A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group." [OMSSA:16, UniMod:34#D] +synonym: "Me1Asp" EXACT PSI-MOD-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "methyld" EXACT OMSSA-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 5 H 7 N 1 O 3" +xref: MassAvg: "129.12" +xref: MassMono: "129.042593" +xref: Origin: "D" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00887 ! methylated aspartic acid + +[Term] +id: MOD:01682 +name: monomethylated L-cysteine +def: "A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group." [OMSSA:73, UniMod:34#C] +subset: PSI-MOD-slim +synonym: "Me1Cys" EXACT PSI-MOD-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "methylc" EXACT OMSSA-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 4 H 7 N 1 O 1 S 1" +xref: MassAvg: "117.17" +xref: MassMono: "117.024835" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00660 ! methylated cysteine + +[Term] +id: MOD:01683 +name: monomethylated L-lysine +def: "A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group." [OMSSA:0] +subset: PSI-MOD-slim +synonym: "Me1Lys" EXACT PSI-MOD-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methylation" RELATED UniMod-description [] +synonym: "methylk" EXACT OMSSA-label [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 7 H 15 N 2 O 2" +xref: MassAvg: "159.21" +xref: MassMono: "159.113353" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00599 ! monomethylated residue +is_a: MOD:00663 ! methylated lysine + +[Term] +id: MOD:01684 +name: palmitoylated-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine." [OMSSA:92, UniMod:47] +subset: PSI-MOD-slim +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +synonym: "palmitoylationc" EXACT OMSSA-label [] +synonym: "PamCys" EXACT PSI-MOD-label [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "C 19 H 35 N 1 O 2 S 1" +xref: MassAvg: "341.55" +xref: MassMono: "341.238850" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00440 ! palmitoylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01685 +name: alpha-amino palmitoylated residue +def: "A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group." [UniMod:47#N-term] +subset: PSI-MOD-slim +synonym: "N2PamRes" EXACT PSI-MOD-label [] +synonym: "Palmitoyl" RELATED PSI-MS-label [] +synonym: "Palmitoylation" RELATED UniMod-description [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00651 ! N-palmitoylated residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:01686 +name: alpha-amino dimethylated residue +def: "A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group." [OMSSA:38, UniMod:36#N-term] +comment: For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889. +synonym: "di-Methylation" RELATED UniMod-description [] +synonym: "Dimethyl" RELATED PSI-MS-label [] +synonym: "N2Me2Res" EXACT PSI-MOD-label [] +synonym: "ntermpepdimethyl" EXACT OMSSA-label [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4" +xref: DiffMono: "28.031300" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "N-term" +is_a: MOD:00429 ! dimethylated residue +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01687 +name: alpha-amino trimethylated residue +def: "A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group." [OMSSA:12, UniMod:37#N-term] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "N2Me3Res" EXACT PSI-MOD-label [] +synonym: "ntermtrimethyl" EXACT OMSSA-label [] +synonym: "tri-Methylation" RELATED UniMod-description [] +synonym: "Trimethyl" RELATED PSI-MS-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0" +xref: DiffMono: "42.046402" +xref: FormalCharge: "1+" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00430 ! trimethylated residue +is_a: MOD:01460 ! alpha-amino methylated residue +relationship: derives_from MOD:01700 ! alpha-amino protonated residue + +[Term] +id: MOD:01688 +name: 3-hydroxy-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues." [OMSSA:61, UniMod:35#N] +subset: PSI-MOD-slim +synonym: "3HyAsn" EXACT PSI-MOD-label [] +synonym: "hydroxylationn" EXACT OMSSA-label [] +synonym: "monohydroxylated asparagine" EXACT PSI-MOD-alternate [] +synonym: "Oxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 4 H 6 N 2 O 3" +xref: MassAvg: "130.10" +xref: MassMono: "130.037842" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00903 ! modified L-asparagine residue + +[Term] +id: MOD:01689 +name: alpha-carboxyl methylated residue +def: "A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester." [OMSSA:18, OMSSA:68, UniMod:34#C-term] +subset: PSI-MOD-slim +synonym: "C1OMeRes" EXACT PSI-MOD-label [] +synonym: "ctermpepmeester" EXACT OMSSA-label [] +synonym: "ctermpepmethyl" EXACT OMSSA-label [] +synonym: "Methyl" RELATED PSI-MS-label [] +synonym: "Methyl" RELATED UniMod-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" +xref: DiffMono: "14.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00393 ! O-methylated residue + +[Term] +id: MOD:01690 +name: N-[(12R)-12-hydroxymyristoyl]-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine." [RESID:AA0516] +synonym: "2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "LIPID N-[(12R)-12-hydroxymyristoyl]cysteine" EXACT UniProt-feature [] +synonym: "N-[(12R)-12-hydroxymyristoyl]-L-cysteine" EXACT RESID-name [] +synonym: "N-[(12R)-12-hydroxytetradecanoyl]cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "226.36" +xref: DiffFormula: "C 14 H 26 N 0 O 2 S 0" +xref: DiffMono: "226.193280" +xref: Formula: "C 17 H 32 N 1 O 3 S 1" +xref: MassAvg: "330.51" +xref: MassMono: "330.210290" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:01691 +name: N-(12-ketomyristoyl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine." [PubMed:19053188, RESID:AA0517] +synonym: "2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "LIPID N-(12-oxomyristoyl)cysteine" EXACT UniProt-feature [] +synonym: "N-(12-ketomyristoyl)-L-cysteine" EXACT RESID-name [] +synonym: "N-(12-oxotetradecanoyl)cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "224.34" +xref: DiffFormula: "C 14 H 24 N 0 O 2 S 0" +xref: DiffMono: "224.177630" +xref: Formula: "C 17 H 30 N 1 O 3 S 1" +xref: MassAvg: "328.49" +xref: MassMono: "328.194640" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:01692 +name: glutamyl semialdehyde (Glu) +def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde." [PubMed:18688235, PubMed:743268] +synonym: "Deoxy" RELATED PSI-MS-label [] +synonym: "gamma-glutamyl semialdehyde" EXACT PSI-MOD-alternate [] +synonym: "glutamyl 5-semialdehyde" EXACT PSI-MOD-alternate [] +synonym: "glutamyl aldehyde" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-16.00" +xref: DiffFormula: "C 0 H 0 N 0 O -1" +xref: DiffMono: "-15.994915" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01161 ! deoxygenated residue +is_a: MOD:01440 ! glutamyl semialdehyde + +[Term] +id: MOD:01693 +name: alpha-amino pyridylacetylated residue +def: "A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group." [OMSSA:107, PubMed:9276974, UniMod:25#N-term] +comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. +synonym: "ntermpeppyridyl" EXACT OMSSA-label [] +synonym: "Pyridylacetyl" RELATED PSI-MS-label [] +synonym: "pyridylacetyl" RELATED UniMod-description [] +xref: DiffAvg: "119.12" +xref: DiffFormula: "C 7 H 5 N 1 O 1" +xref: DiffMono: "119.037114" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00418 ! pyridylacetylated residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:01694 +name: S-(coelenterazin-3a-yl)-L-cysteine +def: "A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine." [ChEBI:2311, PubMed:18997450, RESID:AA0526] +synonym: "(2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "dehydrocoelenterazine cysteine adduct" EXACT RESID-alternate [] +synonym: "MOD_RES S-(coelenterazin-3a-yl)cysteine" EXACT UniProt-feature [] +synonym: "S-(coelenterazin-3a-yl)-L-cysteine" EXACT RESID-name [] +synonym: "symplectin chromophore" EXACT RESID-alternate [] +xref: DiffAvg: "421.46" +xref: DiffFormula: "C 26 H 19 N 3 O 3 S 0" +xref: DiffMono: "421.142641" +xref: Formula: "C 29 H 24 N 4 O 4 S 1" +xref: MassAvg: "524.60" +xref: MassMono: "524.151826" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01695 +name: alpha-amino 3-(carboxamidomethylthio)propanoylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group." [PubMed:15121203, UniMod:293#N-term] +synonym: "3-(carbamidomethylthio)propanoyl" RELATED UniMod-description [] +synonym: "CAMthiopropanoyl" RELATED PSI-MS-label [] +xref: DiffAvg: "145.18" +xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1" +xref: DiffMono: "145.019749" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00612 ! 3-(carboxamidomethylthio)propanoylated residue +is_a: MOD:01696 ! alpha-amino acylated residue + +[Term] +id: MOD:01696 +name: alpha-amino acylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00670 ! N-acylated residue + +[Term] +id: MOD:01697 +name: alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group." [DeltaMass:235, PubMed:8597590, UniMod:276#N-term] +comment: See the comment for MOD:00596 [JSG]. +synonym: "AEBS" RELATED PSI-MS-label [] +synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] +xref: DiffAvg: "183.23" +xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" +xref: DiffMono: "183.035400" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue + +[Term] +id: MOD:01698 +name: alpha-amino trimethylated protonated-residue +def: "A protein modification that effectively replaces an amino group with a trimethylaminium group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "N2Me3+Res" EXACT PSI-MOD-label [] +synonym: "tri-Methylation" RELATED UniMod-description [] +synonym: "Trimethyl" RELATED PSI-MS-label [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0" +xref: DiffMono: "43.054227" +xref: FormalCharge: "1+" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00711 ! trimethylated protonated-residue +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01699 +name: protonated residue +def: "A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "H+NRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01700 +name: alpha-amino protonated residue +def: "A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "N2H+NRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01699 ! protonated residue + +[Term] +id: MOD:01701 +name: deprotonated residue +def: "A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "H-NRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007276" +xref: FormalCharge: "1-" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01156 ! protein modification categorized by chemical process + +[Term] +id: MOD:01702 +name: alpha-carboxyl deprotonated residue +def: "A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "C1H-NRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0" +xref: DiffMono: "-1.007276" +xref: FormalCharge: "1-" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01701 ! deprotonated residue + +[Term] +id: MOD:01703 +name: dehydrobutyrine +def: "A protein modification that effectively converts a source amino acid residue to dehydrobutyrine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "beta-elim-t" EXACT OMSSA-label [] +synonym: "Dehydrated" RELATED PSI-MS-label [] +synonym: "Dehydrated" RELATED UniMod-interim [] +synonym: "Dehydration" RELATED UniMod-description [] +synonym: "dehydro" EXACT OMSSA-label [] +synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] +synonym: "dHAbu" EXACT PSI-MOD-label [] +synonym: "phospholosst" EXACT OMSSA-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01704 +name: dehydrobutyrine (Met) +def: "A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide." [PubMed:18688235] +comment: It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG]. +subset: PSI-MOD-slim +synonym: "dHAbu(Met)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-48.10" +xref: DiffFormula: "C -1 H -4 N 0 O 0 S -1" +xref: DiffMono: "-48.003371" +xref: Formula: "C 4 H 5 N 1 O 1" +xref: MassAvg: "83.09" +xref: MassMono: "83.037114" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01703 ! dehydrobutyrine + +[Term] +id: MOD:01705 +name: isotope tagged reagent acylated residue +def: "A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:01706 +name: isotope tagged reagent N-acylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00670 ! N-acylated residue + +[Term] +id: MOD:01707 +name: isotope tagged reagent O-acylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group." [PubMed:18688235] +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00671 ! O-acylated residue + +[Term] +id: MOD:01708 +name: isotope tagged reagent alpha-amino acylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01696 ! alpha-amino acylated residue +is_a: MOD:01705 ! isotope tagged reagent acylated residue +is_a: MOD:01706 ! isotope tagged reagent N-acylated residue + +[Term] +id: MOD:01709 +name: iTRAQ4plex reporter+balance reagent N-acylated residue +def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01706 ! isotope tagged reagent N-acylated residue + +[Term] +id: MOD:01710 +name: iTRAQ8plex reporter+balance reagent N-acylated residue +def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01706 ! isotope tagged reagent N-acylated residue + +[Term] +id: MOD:01711 +name: iTRAQ4plex reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [UniMod:214#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue +is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01712 +name: iTRAQ8plex reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [UniMod:214#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue +is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01713 +name: iTRAQ4plex reporter+balance reagent O-acylated residue +def: "A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01707 ! isotope tagged reagent O-acylated residue + +[Term] +id: MOD:01714 +name: iTRAQ8plex reporter+balance reagent O-acylated residue +def: "A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01707 ! isotope tagged reagent O-acylated residue + +[Term] +id: MOD:01715 +name: TMT6plex reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group." [UniMod:214] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01705 ! isotope tagged reagent acylated residue + +[Term] +id: MOD:01716 +name: TMT6plex reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex reporter fragment" EXACT PSI-MOD-alternate [] +is_a: MOD:01520 ! modification reporter fragment +relationship: derives_from MOD:01715 ! TMT6plex reporter+balance reagent acylated residue +relationship: derives_from MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01717 +name: TMT6plex reporter+balance reagent N-acylated residue +def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01706 ! isotope tagged reagent N-acylated residue + +[Term] +id: MOD:01718 +name: TMT6plex reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group." [UniMod:214#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue + +[Term] +id: MOD:01719 +name: TMT6plex reporter+balance reagent O-acylated residue +def: "A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01707 ! isotope tagged reagent O-acylated residue + +[Term] +id: MOD:01720 +name: TMT6plex-126 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01721 +name: TMT6plex-126 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal +is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue + +[Term] +id: MOD:01722 +name: TMT6plex-126 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" +xref: MassAvg: "357.26" +xref: MassMono: "357.257895" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01723 +name: TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "392.23" +xref: MassMono: "392.226261" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue + +[Term] +id: MOD:01724 +name: TMT6plex-126 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" +xref: MassAvg: "366.22" +xref: MassMono: "366.221844" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue + +[Term] +id: MOD:01725 +name: TMT6plex-126 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "316.19" +xref: MassMono: "316.194961" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue + +[Term] +id: MOD:01726 +name: TMT6plex-126 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "330.21" +xref: MassMono: "330.210611" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue + +[Term] +id: MOD:01727 +name: TMT6plex-126 reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex-126 reporter fragment" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 8 H 16 (14)N 1" +xref: MassAvg: "126.13" +xref: MassMono: "126.127726" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01716 ! TMT6plex reporter fragment +relationship: derives_from MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue +relationship: derives_from MOD:01822 ! cysTMT6plex-zero reporter+balance reagent cysteine disulfide +relationship: derives_from MOD:01823 ! cysTMT6plex-126 reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01728 +name: TMT6plex-127 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01729 +name: TMT6plex-127 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal +is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue + +[Term] +id: MOD:01730 +name: TMT6plex-127 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" +xref: MassAvg: "357.26" +xref: MassMono: "357.257895" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01731 +name: TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: MassAvg: "229.16" +xref: MassMono: "229.162932" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue + +[Term] +id: MOD:01732 +name: TMT6plex-127 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" +xref: MassAvg: "366.22" +xref: MassMono: "366.221844" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue + +[Term] +id: MOD:01733 +name: TMT6plex-127 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "316.19" +xref: MassMono: "316.194961" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue + +[Term] +id: MOD:01734 +name: TMT6plex-127 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "330.21" +xref: MassMono: "330.210611" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue + +[Term] +id: MOD:01735 +name: TMT6plex-127 reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex-127 reporter fragment" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 7 (13)C 1 H 16 (14)N 1" +xref: MassAvg: "127.13" +xref: MassMono: "127.131081" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01716 ! TMT6plex reporter fragment +relationship: derives_from MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue +relationship: derives_from MOD:01824 ! cysTMT6plex-127 reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01736 +name: TMT6plex-128 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01737 +name: TMT6plex-128 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal +is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue + +[Term] +id: MOD:01738 +name: TMT6plex-128 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" +xref: MassAvg: "357.26" +xref: MassMono: "357.257895" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01739 +name: TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "392.23" +xref: MassMono: "392.226261" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue + +[Term] +id: MOD:01740 +name: TMT6plex-128 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" +xref: MassAvg: "366.22" +xref: MassMono: "366.221844" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue + +[Term] +id: MOD:01741 +name: TMT6plex-128 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "316.19" +xref: MassMono: "316.194961" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue + +[Term] +id: MOD:01742 +name: TMT6plex-128 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "330.21" +xref: MassMono: "330.210611" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue + +[Term] +id: MOD:01743 +name: TMT6plex-128 reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex-128 reporter fragment" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 6 (13)C 2 H 16 (14)N 1" +xref: MassAvg: "128.13" +xref: MassMono: "128.134436" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01716 ! TMT6plex reporter fragment +relationship: derives_from MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue +relationship: derives_from MOD:01825 ! cysTMT6plex-128 reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01744 +name: TMT6plex-129 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue + +[Term] +id: MOD:01745 +name: TMT6plex-129 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal +is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue + +[Term] +id: MOD:01746 +name: TMT6plex-129 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" +xref: MassAvg: "357.26" +xref: MassMono: "357.257895" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01747 +name: TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "392.23" +xref: MassMono: "392.226261" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue + +[Term] +id: MOD:01748 +name: TMT6plex-129 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" +xref: MassAvg: "366.22" +xref: MassMono: "366.221844" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue + +[Term] +id: MOD:01749 +name: TMT6plex-129 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "316.19" +xref: MassMono: "316.194961" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue + +[Term] +id: MOD:01750 +name: TMT6plex-129 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "330.21" +xref: MassMono: "330.210611" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue + +[Term] +id: MOD:01751 +name: TMT6plex-129 reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex-129 reporter fragment" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 5 (13)C 3 H 16 (14)N 1" +xref: MassAvg: "129.14" +xref: MassMono: "129.137790" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01716 ! TMT6plex reporter fragment +relationship: derives_from MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue +relationship: derives_from MOD:01826 ! cysTMT6plex-129 reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01752 +name: TMT6plex-130 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue +relationship: derives_from MOD:01827 ! cysTMT6plex-130 reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01753 +name: TMT6plex-130 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal +is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue + +[Term] +id: MOD:01754 +name: TMT6plex-130 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" +xref: MassAvg: "357.26" +xref: MassMono: "357.257895" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01755 +name: TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "392.23" +xref: MassMono: "392.226261" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue + +[Term] +id: MOD:01756 +name: TMT6plex-130 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" +xref: MassAvg: "366.22" +xref: MassMono: "366.221844" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue + +[Term] +id: MOD:01757 +name: TMT6plex-130 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "316.19" +xref: MassMono: "316.194961" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue + +[Term] +id: MOD:01758 +name: TMT6plex-130 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "330.21" +xref: MassMono: "330.210611" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue + +[Term] +id: MOD:01759 +name: TMT6plex-130 reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex-130 reporter fragment" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 4 (13)C 4 H 16 (14)N 1" +xref: MassAvg: "130.14" +xref: MassMono: "130.141145" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01716 ! TMT6plex reporter fragment +relationship: derives_from MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue + +[Term] +id: MOD:01760 +name: TMT6plex-131 reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "cysTMT6plex-131 reporter fragment" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue +relationship: derives_from MOD:01828 ! cysTMT6plex-131 reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01761 +name: TMT6plex-131 reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal +is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue + +[Term] +id: MOD:01762 +name: TMT6plex-131 reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" +xref: MassAvg: "357.26" +xref: MassMono: "357.257895" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01763 +name: TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "392.23" +xref: MassMono: "392.226261" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue + +[Term] +id: MOD:01764 +name: TMT6plex-131 reporter+balance reagent N'-acylated histidine +def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" +xref: MassAvg: "366.22" +xref: MassMono: "366.221844" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue +is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue + +[Term] +id: MOD:01765 +name: TMT6plex-131 reporter+balance reagent O3-acylated serine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "316.19" +xref: MassMono: "316.194961" +xref: Origin: "S" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue + +[Term] +id: MOD:01766 +name: TMT6plex-131 reporter+balance reagent O3-acylated threonine +def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "229.16" +xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" +xref: DiffMono: "229.162932" +xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" +xref: MassAvg: "330.21" +xref: MassMono: "330.210611" +xref: Origin: "T" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue +is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue + +[Term] +id: MOD:01767 +name: TMT6plex-131 reporter fragment +def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue." [PubMed:18688235] +synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] +synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "TMT6plex" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 4 (13)C 4 H 16 (15)N 1" +xref: MassAvg: "131.14" +xref: MassMono: "131.138180" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01716 ! TMT6plex reporter fragment +relationship: derives_from MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue + +[Term] +id: MOD:01768 +name: O-palmitoleylated residue +def: "A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "236.40" +xref: DiffFormula: "C 16 H 28 N 0 O 1" +xref: DiffMono: "236.214016" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00671 ! O-acylated residue +is_a: MOD:01423 ! palmitoleylated residue + +[Term] +id: MOD:01769 +name: O-palmitoleyl-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine." [OMSSA:188, PubMed:6642431, PubMed:8413602, RESID:AA0079#var, UniMod:431#T] +subset: PSI-MOD-slim +synonym: "(2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid" EXACT PSI-MOD-alternate [] +synonym: "L-threonine cis-9-hexadecenoate ester" EXACT PSI-MOD-alternate [] +synonym: "mod188" EXACT OMSSA-label [] +synonym: "O-palmitoleylated L-threonine" EXACT PSI-MOD-alternate [] +synonym: "O3-palmitoleyl-threonine" EXACT PSI-MOD-alternate [] +synonym: "Palmitoleyl" RELATED PSI-MS-label [] +synonym: "palmitoleyl" RELATED UniMod-description [] +xref: DiffAvg: "236.40" +xref: DiffFormula: "C 16 H 28 N 0 O 1" +xref: DiffMono: "236.214016" +xref: Formula: "C 20 H 35 N 1 O 3" +xref: MassAvg: "337.50" +xref: MassMono: "337.261694" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01768 ! O-palmitoleylated residue + +[Term] +id: MOD:01770 +name: O-palmitoyl-L-threonine amide +def: "A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide." [PubMed:8413602, RESID:AA0079#var, RESID:AA0097#var] +synonym: "(2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide" EXACT PSI-MOD-alternate [] +synonym: "OPamThrN" EXACT PSI-MOD-label [] +xref: DiffAvg: "254.44" +xref: DiffFormula: "C 16 H 32 N 1 O 1" +xref: DiffMono: "254.248390" +xref: Formula: "C 20 H 39 N 2 O 3" +xref: MassAvg: "355.54" +xref: MassMono: "355.296068" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00917 ! modified L-threonine residue +relationship: has_functional_parent MOD:00088 ! O-palmitoyl-L-threonine +relationship: has_functional_parent MOD:00106 ! L-threonine amide + +[Term] +id: MOD:01771 +name: farnesyl reporter fragment +def: "The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues." [PubMed:15609361, PubMed:18688235] +subset: PSI-MOD-slim +synonym: "(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium" EXACT PSI-MOD-alternate [] +synonym: "Farn+" EXACT PSI-MOD-label [] +synonym: "farnesyl cation" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "C 15 H 25" +xref: MassAvg: "205.36" +xref: MassMono: "205.195077" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01520 ! modification reporter fragment +relationship: derives_from MOD:00437 ! farnesylated residue + +[Term] +id: MOD:01772 +name: palmityl reporter fragment +def: "The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues." [PubMed:18688235, PubMed:8413602] +subset: PSI-MOD-slim +synonym: "palmityl cation" RELATED PSI-MS-label [] +synonym: "Pam+" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "C 16 H 31 O 1" +xref: MassAvg: "239.42" +xref: MassMono: "239.236942" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01520 ! modification reporter fragment +relationship: derives_from MOD:00440 ! palmitoylated residue + +[Term] +id: MOD:01773 +name: N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine +def: "Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment." [PubMed:17205979, PubMed:18688235] +subset: PSI-MOD-slim +synonym: "dMe3N6Me3+Lys" EXACT PSI-MOD-label [] +xref: DiffAvg: "-59.11" +xref: DiffFormula: "C -3 H -9 N -1 O 0" +xref: DiffMono: "-59.074048" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 10 N 1 O 1" +xref: MassAvg: "112.15" +xref: MassMono: "112.075690" +xref: Origin: "MOD:00083" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00431 ! modified residue with a secondary neutral loss +is_a: MOD:00912 ! modified L-lysine residue +relationship: derives_from MOD:00083 ! N6,N6,N6-trimethyl-L-lysine + +[Term] +id: MOD:01774 +name: N6-octanoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine." [PubMed:12591875, PubMed:2215217, RESID:AA0527] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-(octanoylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "epsilon-octanoyllysine" EXACT RESID-alternate [] +synonym: "N(zeta)-octanoyllysine" EXACT RESID-alternate [] +synonym: "N6-(1-oxooctyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-octanoyl-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "126.20" +xref: DiffFormula: "C 8 H 14 N 0 O 1" +xref: DiffMono: "126.104465" +xref: Formula: "C 14 H 26 N 2 O 2" +xref: MassAvg: "254.37" +xref: MassMono: "254.199428" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00666 ! octanoylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01775 +name: 5-glutamyl serotonin +def: "A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin." [PubMed:11805836, PubMed:14697203, RESID:AA0528] +synonym: "(2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "5-glutamyl serotonin" EXACT RESID-name [] +synonym: "N2-(gamma-glutamyl)-5-hydoxytryptamine" EXACT RESID-alternate [] +synonym: "N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine" EXACT RESID-alternate [] +xref: DiffAvg: "159.19" +xref: DiffFormula: "C 10 H 9 N 1 O 1" +xref: DiffMono: "159.068414" +xref: Formula: "C 15 H 17 N 3 O 3" +xref: MassAvg: "287.32" +xref: MassMono: "287.126991" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:01776 +name: S-methylthiocarbonylaminoethylcysteine (Cys) +def: "A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine." [PubMed:18688235, PubMed:20608637] +comment: This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate). +synonym: "(2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid" EXACT PSI-MOD-alternate [] +synonym: "L-cysteine N-(methylthiocarbonyl)aziridine adduct" EXACT PSI-MOD-alternate [] +synonym: "MTCTK" EXACT PSI-MOD-alternate [] +synonym: "N6-methylthiocarbonyl-4-thialysine" EXACT PSI-MOD-alternate [] +synonym: "S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "117.17" +xref: DiffFormula: "C 4 H 7 N 1 O 1 S 1" +xref: DiffMono: "117.024835" +xref: Formula: "C 7 H 12 N 2 O 2 S 2" +xref: MassAvg: "220.31" +xref: MassMono: "220.034020" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01777 +name: S-(glycyl)-L-cysteine (Gly) +def: "A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine." [ChEBI:22050, PubMed:17726030, PubMed:18359941, PubMed:18771296, PubMed:18799456, PubMed:18842002, PubMed:3306404, RESID:AA0206] +comment: This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG]. +synonym: "(2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid" EXACT RESID-systematic [] +synonym: "1-(cystein-S-yl)-glycinate" EXACT RESID-alternate [] +synonym: "glycine cysteine thioester" EXACT RESID-alternate [] +synonym: "MOD_RES CysO-cysteine adduct" EXACT UniProt-feature [] +synonym: "S-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(glycyl)-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "103.14" +xref: DiffFormula: "C 3 H 5 N 1 O 1 S 1" +xref: DiffMono: "103.009185" +xref: Formula: "C 5 H 9 N 2 O 3 S 1" +xref: MassAvg: "177.20" +xref: MassMono: "177.033388" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:01778 +name: N-(glycyl)-L-cysteine +def: "A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine." [PubMed:18771296, PubMed:18799456, PubMed:18842002, RESID:AA0529] +synonym: "(2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES CysO-cysteine adduct" EXACT UniProt-feature [] +synonym: "N-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate [] +synonym: "N-(glycyl)-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "103.14" +xref: DiffFormula: "C 3 H 5 N 1 O 1 S 1" +xref: DiffMono: "103.009185" +xref: Formula: "C 5 H 9 N 2 O 3 S 1" +xref: MassAvg: "177.20" +xref: MassMono: "177.033388" +xref: Origin: "G" +xref: Source: "hypothetical" +xref: TermSpec: "C-term" +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:01779 +name: N6-(L-lysyl)-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine." [PubMed:18201202, PubMed:20729861, RESID:AA0530] +comment: This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG]. +synonym: "(2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "N6-(alpha-lysyl)-lysine" EXACT RESID-alternate [] +synonym: "N6-(L-lysyl)-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "128.18" +xref: DiffFormula: "C 6 H 12 N 2 O 1" +xref: DiffMono: "128.094963" +xref: Formula: "C 12 H 24 N 4 O 2" +xref: MassAvg: "256.35" +xref: MassMono: "256.189926" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01780 +name: N6-(beta-lysyl)-L-5-hydroxylysine +def: "A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine." [PubMed:18201202, PubMed:20729861, RESID:AA0531] +synonym: "(2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid" EXACT RESID-systematic [] +synonym: "5-hydroxy-N6-(beta-lysyl)-L-lysine" EXACT RESID-name [] +synonym: "5-hydroxy-N6-[(3R)-beta-lysyl]lysine" EXACT RESID-alternate [] +synonym: "EF-P lysine derivative" EXACT RESID-alternate [] +synonym: "lysyl spermidine derivative [misidentification]" EXACT RESID-alternate [] +synonym: "MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine" EXACT UniProt-feature [] +synonym: "N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine" EXACT RESID-alternate [] +xref: DiffAvg: "144.17" +xref: DiffFormula: "C 6 H 12 N 2 O 2" +xref: DiffMono: "144.089878" +xref: Formula: "C 12 H 24 N 4 O 3" +xref: MassAvg: "272.35" +xref: MassMono: "272.184841" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00037 ! 5-hydroxy-L-lysine +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01781 +name: N6-butanoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine." [PubMed:17267393, PubMed:20715035, RESID:AA0532, UniMod:1289] +comment: The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. +synonym: "(2S)-2-amino-6-(butanoylamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-azanyl-6-(butanoylamino)hexanoic acid" EXACT RESID-alternate [] +synonym: "2-amino-6-butyrylaminocaproic acid" EXACT RESID-alternate [] +synonym: "epsilon-butanoyl-L-lysine" EXACT RESID-alternate [] +synonym: "epsilon-butyryl-L-lysine" EXACT RESID-alternate [] +synonym: "N(zeta)-butanoyllysine" EXACT RESID-alternate [] +synonym: "N6-(1-oxobutyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-butanoyl-L-lysine" EXACT RESID-name [] +synonym: "N6-butyryllysine" EXACT RESID-alternate [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 N 0 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "C 10 H 18 N 2 O 2" +xref: MassAvg: "198.27" +xref: MassMono: "198.136828" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine +is_a: MOD:01997 ! N-butanoylated residue + +[Term] +id: MOD:01782 +name: N-methyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to N-methyl-L-serine." [PubMed:20668449, RESID:AA0533] +subset: PSI-MOD-slim +synonym: "(2S)-3-hydroxy-2-(methylamino)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N-methylserine" EXACT UniProt-feature [] +synonym: "N-methyl-L-serine" EXACT RESID-name [] +synonym: "N-methylserine" EXACT RESID-alternate [] +xref: DiffAvg: "14.03" +xref: DiffFormula: "C 1 H 2 N 0 O 0" +xref: DiffMono: "14.015650" +xref: Formula: "C 4 H 7 N 1 O 2" +xref: MassAvg: "101.10" +xref: MassMono: "101.047678" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01680 ! alpha-amino monomethylated residue +is_a: MOD:01800 ! N-methylated serine + +[Term] +id: MOD:01783 +name: N,N-dimethyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine." [PubMed:20668449, RESID:AA0534] +synonym: "(2S)-2-(dimethylamino)propanoic acid" EXACT RESID-systematic [] +synonym: "MOD_RES N,N-dimethylserine" EXACT UniProt-feature [] +synonym: "N,N-dimethyl-L-serine" EXACT RESID-name [] +synonym: "N,N-dimethylserine" EXACT RESID-alternate [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 5 H 10 N 1 O 2" +xref: MassAvg: "116.14" +xref: MassMono: "116.071154" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01686 ! alpha-amino dimethylated residue +is_a: MOD:01800 ! N-methylated serine + +[Term] +id: MOD:01784 +name: N,N,N-trimethyl-L-serine +def: "A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine." [PubMed:20668449, PubMed:3979397, RESID:AA0535] +subset: PSI-MOD-slim +synonym: "(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium" EXACT RESID-systematic [] +synonym: "(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium" EXACT RESID-alternate [] +synonym: "(2S)-2-trimethylammonio-3-hydroxypropanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N,N,N-trimethylserine" EXACT UniProt-feature [] +synonym: "N,N,N-trimethyl-L-serine" EXACT RESID-name [] +synonym: "N,N,N-trimethylserine cation" EXACT RESID-alternate [] +synonym: "N,N,N-trimethylserinium" EXACT RESID-alternate [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0" +xref: DiffMono: "43.054227" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 13 N 1 O 2" +xref: MassAvg: "131.17" +xref: MassMono: "131.094080" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue +is_a: MOD:01800 ! N-methylated serine + +[Term] +id: MOD:01785 +name: O-(L-isoglutamyl)-L-threonine (active site intermediate) +def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia." [PubMed:8706862, RESID:AA0536#THR] +comment: This is not an ester cross-link of peptides [JSG]. +synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] +synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] +synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] +xref: DiffAvg: "129.12" +xref: DiffFormula: "C 5 H 7 N 1 O 3" +xref: DiffMono: "129.042593" +xref: Formula: "C 9 H 14 N 2 O 5" +xref: MassAvg: "230.22" +xref: MassMono: "230.090272" +xref: Origin: "T" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00671 ! O-acylated residue +is_a: MOD:01979 ! O-(L-isoglutamyl)-L-threonine + +[Term] +id: MOD:01786 +name: 3'-nitro-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine." [ChEBI:44454, PubMed:16944230, PubMed:5339594, RESID:AA0537] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "3'-nitro-L-tyrosine" EXACT RESID-name [] +synonym: "3-nitro-L-tyrosine" EXACT RESID-alternate [] +synonym: "3-nitrotyrosine" EXACT RESID-alternate [] +synonym: "m-nitrotyrosine" EXACT RESID-alternate [] +synonym: "meta-nitrotyrosine" EXACT RESID-alternate [] +synonym: "MOD_RES 3'-Nitrotyrosine" EXACT UniProt-feature [] +xref: DiffAvg: "45.00" +xref: DiffFormula: "C 0 H -1 N 1 O 2" +xref: DiffMono: "44.985078" +xref: Formula: "C 9 H 8 N 2 O 4" +xref: MassAvg: "208.17" +xref: MassMono: "208.048407" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01352 ! nitrated L-tyrosine + +[Term] +id: MOD:01787 +name: 5'-(L-tyros-5'-yl)amino-L-tyrosine +def: "A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine." [PubMed:18781570, RESID:AA0459] +comment: Cross-link 2. +synonym: "(2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "5'-(L-tyros-5'-yl)amino-L-tyrosine" EXACT RESID-name [] +synonym: "5'-[(tyros-5'-yl)amino]tyrosine" EXACT RESID-alternate [] +synonym: "5'-tyrosyl-5'-aminotyrosine" EXACT RESID-alternate [] +synonym: "bis(LTQ) linkage" EXACT RESID-alternate [] +synonym: "CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain)" EXACT UniProt-feature [] +xref: DiffAvg: "13.00" +xref: DiffFormula: "C 0 H -1 N 1 O 0" +xref: DiffMono: "12.995249" +xref: Formula: "C 18 H 17 N 3 O 4" +xref: MassAvg: "339.35" +xref: MassMono: "339.121906" +xref: Origin: "Y, Y" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01788 +name: histidine immonium ion +def: "A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion." [PubMed:17074506, PubMed:18688235] +comment: This fragment corresponds to the first ion in an a+ series. +subset: PSI-MOD-slim +synonym: "2-(1H-imidazolyl)ethaniminium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 8 N 3 O 0" +xref: MassAvg: "110.14" +xref: MassMono: "110.071274" +xref: Origin: "H" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01527 ! residue reporter fragment + +[Term] +id: MOD:01789 +name: phenylalanine immonium ion +def: "A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion." [PubMed:17074506, PubMed:18688235] +comment: This fragment corresponds to the first ion in an a+ series. +subset: PSI-MOD-slim +synonym: "2-phenylethaniminium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 8 H 10 N 1 O 0" +xref: MassAvg: "120.17" +xref: MassMono: "120.080776" +xref: Origin: "F" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01527 ! residue reporter fragment + +[Term] +id: MOD:01790 +name: tyrosine immonium ion +def: "A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion." [PubMed:17074506, PubMed:18688235] +comment: This fragment corresponds to the first ion in an a+ series. +subset: PSI-MOD-slim +synonym: "2-(4-hydroxyphenyl)ethaniminium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 8 H 10 N 1 O 1" +xref: MassAvg: "136.17" +xref: MassMono: "136.075690" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01527 ! residue reporter fragment + +[Term] +id: MOD:01791 +name: phosphohistidine immonium ion +def: "A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion." [PubMed:17690871, PubMed:18688235, PubMed:20847263] +comment: This fragment corresponds to the first ion in an a+ series. +subset: PSI-MOD-slim +synonym: "2-(1H-imidazolyl)ethaniminium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 9 N 3 O 3 P 1" +xref: MassAvg: "190.12" +xref: MassMono: "190.037604" +xref: Origin: "MOD:00890" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01527 ! residue reporter fragment +relationship: derives_from MOD:00890 ! phosphorylated L-histidine + +[Term] +id: MOD:01792 +name: phosphotyrosine immonium ion +def: "A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion." [PubMed:17690871, PubMed:18688235] +comment: This fragment corresponds to the first ion in an a+ series. +subset: PSI-MOD-slim +synonym: "2-(4-phosphonoxyphenyl)ethaniminium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 8 H 11 N 1 O 4 P 1" +xref: MassAvg: "216.15" +xref: MassMono: "216.042021" +xref: Origin: "MOD:00048" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01527 ! residue reporter fragment +relationship: derives_from MOD:00048 ! O4'-phospho-L-tyrosine + +[Term] +id: MOD:01793 +name: S-carboxamidomethyl-L-cysteine sulfoxide +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide." [PubMed:11212008, PubMed:17689096, PubMed:18306178, PubMed:18688235] +synonym: "CamCO" EXACT PSI-MOD-alternate [] +synonym: "S-carbamoylmethyl-L-cysteine sulfoxide" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "73.05" +xref: DiffFormula: "C 2 H 3 N 1 O 2" +xref: DiffMono: "73.016378" +xref: Formula: "C 5 H 8 N 2 O 3 S 1" +xref: MassAvg: "176.19" +xref: MassMono: "176.025563" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:01854 ! sulfur monooxygenated residue +relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine + +[Term] +id: MOD:01794 +name: 1x(13)C,3x(2)H labeled monomethylated residue +def: "A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue." [PubMed:18688235] +synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "18.04" +xref: DiffFormula: "(13)C 1 (1)H -1 (2)H 3" +xref: DiffMono: "18.037835" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00842 ! (13)C labeled residue + +[Term] +id: MOD:01795 +name: 1x(13)C,3x(2)H C(6)-labeled L-methionine +def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine." [PubMed:15782174, PubMed:18688235] +synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "4.02" +xref: DiffFormula: "(12)C -1 (13)C 1 (1)H -3 (2)H 3" +xref: DiffMono: "4.022185" +xref: Formula: "(12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 1 S 1" +xref: MassAvg: "135.06" +xref: MassMono: "135.062670" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01794 ! 1x(13)C,3x(2)H labeled monomethylated residue + +[Term] +id: MOD:01796 +name: 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide +def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide." [PubMed:15782174, PubMed:18688235] +xref: DiffAvg: "20.02" +xref: DiffFormula: "(12)C -1 (13)C 1 (1)H -3 (2)H 3 O 1" +xref: DiffMono: "20.017100" +xref: Formula: "(12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 2 S 1" +xref: MassAvg: "151.06" +xref: MassMono: "151.057585" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00839 ! (2)H deuterium labeled residue +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01794 ! 1x(13)C,3x(2)H labeled monomethylated residue + +[Term] +id: MOD:01797 +name: 1'-phosphohistidine immonium ion +def: "A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion." [PubMed:17690871, PubMed:18688235, PubMed:20847263] +comment: This fragment corresponds to the first ion in an a+ series. +synonym: "2-((1-phosphono-1H-imidazol-4-yl)ethaniminium" EXACT PSI-MOD-alternate [] +synonym: "Ntau-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 9 N 3 O 3 P 1" +xref: MassAvg: "190.12" +xref: MassMono: "190.037604" +xref: Origin: "MOD:00044" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01791 ! phosphohistidine immonium ion +relationship: derives_from MOD:00044 ! 1'-phospho-L-histidine + +[Term] +id: MOD:01798 +name: 3'-phosphohistidine immonium ion +def: "A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion." [PubMed:18688235] +comment: This fragment corresponds to the first ion in an a+ series. +synonym: "2-(1-phosphono-1H-imidazol-5-yl)ethaniminium" EXACT PSI-MOD-alternate [] +synonym: "Npi-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-27.00" +xref: DiffFormula: "C -1 H 1 N 0 O -1" +xref: DiffMono: "-26.987638" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 9 N 3 O 3 P 1" +xref: MassAvg: "190.12" +xref: MassMono: "190.037604" +xref: Origin: "MOD:00045" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01791 ! phosphohistidine immonium ion +relationship: derives_from MOD:00045 ! 3'-phospho-L-histidine + +[Term] +id: MOD:01799 +name: methylated serine +def: "A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeSer" EXACT PSI-MOD-label [] +xref: Origin: "S" +is_a: MOD:00427 ! methylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01800 +name: N-methylated serine +def: "A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01460 ! alpha-amino methylated residue +is_a: MOD:01799 ! methylated serine + +[Term] +id: MOD:01801 +name: protonated L-serine (L-serinium) residue +def: "A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine)." [PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "C 3 H 7 N 1 O 2" +xref: MassAvg: "89.09" +xref: MassMono: "89.047130" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01700 ! alpha-amino protonated residue + +[Term] +id: MOD:01802 +name: N,N,N-trimethyl-L-serine (from L-serinium) +def: "A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine." [PubMed:18688235] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ser process (MOD:00071) accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "N2Me3Ala" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0" +xref: DiffMono: "42.046402" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 13 N 1 O 2" +xref: MassAvg: "131.17" +xref: MassMono: "131.094080" +xref: Origin: "MOD:01801" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01687 ! alpha-amino trimethylated residue +relationship: derives_from MOD:01801 ! protonated L-serine (L-serinium) residue + +[Term] +id: MOD:01803 +name: O-methylated threonine +def: "A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester." [PubMed:18688235] +synonym: "OMeThr" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00393 ! O-methylated residue +is_a: MOD:01418 ! methylated threonine + +[Term] +id: MOD:01804 +name: glycosylphosphorylated residue +def: "A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond." [PubMed:18688235] +is_a: MOD:00764 ! glycoconjugated residue +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:01805 +name: N-(L-isoaspartyl)-glycine (Asp) +def: "A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water." [ChEBI:21479, PubMed:1826288, PubMed:18671394, RESID:AA0126] +comment: Cross-link 2. +synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly)" EXACT UniProt-feature [] +synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp)" EXACT UniProt-feature [] +synonym: "isoaspartyl glycine" EXACT RESID-alternate [] +synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name [] +synonym: "N-beta-aspartylglycine" EXACT RESID-alternate [] +synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 7 N 2 O 3" +xref: MassAvg: "155.13" +xref: MassMono: "155.045667" +xref: Origin: "D, G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01928 ! N-(L-isoaspartyl)-glycine + +[Term] +id: MOD:01806 +name: N,N-dimethyl-L-leucine +def: "A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine." [PubMed:19522542, RESID:AA0538] +synonym: "(2S)-2-(dimethylamino)-4-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-(dimethylamino)-4-methylvaleric acid" EXACT RESID-alternate [] +synonym: "2-(dimethylazanyl)-4-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N,N-dimethylleucine" EXACT UniProt-feature [] +synonym: "N,N-dimethyl-L-leucine" EXACT RESID-name [] +synonym: "N,N-dimethylleucine" EXACT RESID-alternate [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 16 N 1 O 1" +xref: MassAvg: "142.22" +xref: MassMono: "142.123189" +xref: Origin: "L" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:01686 ! alpha-amino dimethylated residue +is_a: MOD:01808 ! N-methylated leucine + +[Term] +id: MOD:01807 +name: N-formyl-L-glutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid." [PubMed:18001127, RESID:AA0539] +synonym: "(2S)-2-(formylamino)pentanedioic acid" EXACT RESID-systematic [] +synonym: "2-(formylazanyl)pentanedioic acid" EXACT RESID-alternate [] +synonym: "2-formamidopentanedioic acid" EXACT RESID-alternate [] +synonym: "2-formylaminopentanedioic acid" EXACT RESID-alternate [] +synonym: "N-formyl-L-glutamic acid" EXACT RESID-name [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 6 H 8 N 1 O 4" +xref: MassAvg: "158.13" +xref: MassMono: "158.045333" +xref: Origin: "E" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01808 +name: N-methylated leucine +def: "A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "MeLeu" EXACT PSI-MOD-label [] +xref: Origin: "L" +is_a: MOD:00662 ! methylated leucine +is_a: MOD:01460 ! alpha-amino methylated residue + +[Term] +id: MOD:01809 +name: 5x(13)C,1x(15)N labeled residue +def: "A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue." [PubMed:12771378, UniMod:268] +synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.01" +xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" +xref: DiffMono: "6.013809" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue +is_a: MOD:00843 ! (15)N labeled residue + +[Term] +id: MOD:01810 +name: 5x(13)C,1x(15)N labeled L-proline +def: "A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline." [PubMed:12771378, UniMod:268#P] +synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.01" +xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" +xref: DiffMono: "6.013809" +xref: Formula: "(13)C 5 H 7 (15)N 1 O 1" +xref: MassAvg: "103.07" +xref: MassMono: "103.066573" +xref: Origin: "P" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue + +[Term] +id: MOD:01811 +name: 5x(13)C,1x(15)N labeled L-methionine +def: "A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine." [PubMed:12771378, UniMod:268#M] +synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.01" +xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" +xref: DiffMono: "6.013809" +xref: Formula: "(13)C 5 H 9 (15)N 1 O 1 S 1" +xref: MassAvg: "137.05" +xref: MassMono: "137.054294" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue + +[Term] +id: MOD:01812 +name: 5x(13)C,1x(15)N labeled L-methionine sulfoxide +def: "A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide." [PubMed:12771378, UniMod:268#M] +synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] +xref: DiffAvg: "6.01" +xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" +xref: DiffMono: "6.013809" +xref: Formula: "(13)C 5 H 9 (15)N 1 O 2 S 1" +xref: MassAvg: "153.05" +xref: MassMono: "153.049209" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00719 ! L-methionine sulfoxide +is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue + +[Term] +id: MOD:01813 +name: morpholine-2-acetylated residue +def: "A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom." [PubMed:10446193, UniMod:29] +comment: The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. +synonym: "N-Succinimidyl-2-morpholine acetate" RELATED UniMod-description [] +synonym: "N-succinimidylmorpholine-2-acetate derivative" EXACT PSI-MOD-alternate [] +synonym: "SMA" RELATED PSI-MS-label [] +xref: DiffAvg: "127.14" +xref: DiffFormula: "C 6 H 9 N 1 O 2" +xref: DiffMono: "127.063329" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +is_a: MOD:00649 ! acylated residue +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01814 +name: L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid +def: "A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid." [PubMed:18406324, PubMed:19678698, PubMed:893891, RESID:AA0540] +comment: Cross-link 3. +synonym: "6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid" EXACT RESID-systematic [] +synonym: "6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid" EXACT RESID-alternate [] +synonym: "L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-54.07" +xref: DiffFormula: "C 0 H -8 N -1 O -2 S 0" +xref: DiffMono: "-54.055504" +xref: Formula: "C 9 H 7 N 2 O 3 S 1" +xref: MassAvg: "223.23" +xref: MassMono: "223.017738" +xref: Origin: "C, S, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01425 ! pyridinyl ring crosslinked residues + +[Term] +id: MOD:01815 +name: L-glutamate thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid." [PubMed:18406324, PubMed:19678698, PubMed:893891, RESID:AA0541] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys)" EXACT UniProt-feature [] +synonym: "L-glutamate thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 8 H 8 N 2 O 3 S 1" +xref: MassAvg: "212.22" +xref: MassMono: "212.025563" +xref: Origin: "C, E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01816 +name: 2'-hydroxy-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan." [PubMed:11714714, RESID:AA0542] +synonym: "(2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "2'-hydroxy-L-tryptophan" EXACT RESID-name [] +synonym: "2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-alternate [] +synonym: "2-hydroxy-L-tryptophan" EXACT RESID-alternate [] +synonym: "2-hydroxy-tryptophan" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 11 H 10 N 2 O 2" +xref: MassAvg: "202.21" +xref: MassMono: "202.074228" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01622 ! monohydroxylated tryptophan + +[Term] +id: MOD:01817 +name: oxidation of tryptophan to 2'-oxo-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan." [PubMed:9461080, RESID:AA0543] +synonym: "(2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid" EXACT RESID-systematic [] +synonym: "2'-oxo-L-tryptophan" EXACT RESID-name [] +synonym: "2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate [] +synonym: "2-oxo-L-tryptophan" EXACT RESID-alternate [] +synonym: "2-oxotryptophan" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 11 H 10 N 2 O 2" +xref: MassAvg: "202.21" +xref: MassMono: "202.074228" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01818 +name: 1'-(L-tryptophan-3'-yl)-L-tryptophan +def: "A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan." [PubMed:20600836, RESID:AA0544] +comment: Cross-link 2. +synonym: "(2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "1-(L-tryptophan-3-yl)-L-tryptophan" EXACT RESID-name [] +synonym: "2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate [] +synonym: "3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole" EXACT RESID-systematic [] +synonym: "3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole" EXACT RESID-alternate [] +synonym: "ditryptophan" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 22 H 18 N 4 O 2" +xref: MassAvg: "370.41" +xref: MassMono: "370.142976" +xref: Origin: "W, W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00918 ! modified L-tryptophan residue + +[Term] +id: MOD:01819 +name: N6-succinyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine." [PubMed:16582421, PubMed:21151122, RESID:AA0545] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid" EXACT RESID-alternate [] +synonym: "4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate" EXACT RESID-alternate [] +synonym: "MOD_RES N6-succinyllysine" EXACT UniProt-feature [] +synonym: "N(epsilon)-(succinyl)lysine" EXACT RESID-alternate [] +synonym: "N6-succinyl-L-lysine" EXACT RESID-name [] +synonym: "succinyllysine" EXACT RESID-alternate [] +xref: DiffAvg: "100.07" +xref: DiffFormula: "C 4 H 4 N 0 O 3" +xref: DiffMono: "100.016044" +xref: Formula: "C 10 H 16 N 2 O 4" +xref: MassAvg: "228.25" +xref: MassMono: "228.111007" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01029 ! succinylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01820 +name: isotope tagged sufhydryl reagent modified cysteine +def: "A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01821 +name: cysTMT6plex reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group." [UniMod:985, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01429 ! (15)N isotope tagged reagent +is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine + +[Term] +id: MOD:01822 +name: cysTMT6plex-zero reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group." [UniMod:984, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysTMT" RELATED UniMod-interim [] +synonym: "Native cysteine-reactive Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "299.17" +xref: DiffFormula: "(12)C 14 H 25 (14)N 3 O 2 S 1" +xref: DiffMono: "299.166748" +xref: Formula: "(12)C 17 H 32 (14)N 4 O 4 S 2" +xref: MassAvg: "420.19" +xref: MassMono: "420.186498" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01823 +name: cysTMT6plex-126 reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.18" +xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" +xref: DiffMono: "304.177202" +xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" +xref: MassAvg: "425.20" +xref: MassMono: "425.196952" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01824 +name: cysTMT6plex-127 reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.18" +xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" +xref: DiffMono: "304.177202" +xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" +xref: MassAvg: "425.20" +xref: MassMono: "425.196952" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01825 +name: cysTMT6plex-128 reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.18" +xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" +xref: DiffMono: "304.177202" +xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" +xref: MassAvg: "425.20" +xref: MassMono: "425.196952" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01826 +name: cysTMT6plex-129 reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.18" +xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" +xref: DiffMono: "304.177202" +xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" +xref: MassAvg: "425.20" +xref: MassMono: "425.196952" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01827 +name: cysTMT6plex-130 reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.18" +xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" +xref: DiffMono: "304.177202" +xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" +xref: MassAvg: "425.20" +xref: MassMono: "425.196952" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01828 +name: cysTMT6plex-131 reporter+balance reagent cysteine disulfide +def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] +comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] +synonym: "cysTMT6plex" RELATED UniMod-interim [] +synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "304.18" +xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" +xref: DiffMono: "304.177202" +xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" +xref: MassAvg: "425.20" +xref: MassMono: "425.196952" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide + +[Term] +id: MOD:01829 +name: S-carboxymethyl-L-cysteine sulfoxide +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide." [PubMed:17689096, PubMed:18688235] +synonym: "CmCO" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "58.04" +xref: DiffFormula: "C 2 H 2 N 0 O 2 S 0" +xref: DiffMono: "58.005479" +xref: Formula: "C 5 H 7 N 1 O 3 S 1" +xref: MassAvg: "161.18" +xref: MassMono: "161.014664" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00399 ! iodoacetic acid derivatized residue +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:01854 ! sulfur monooxygenated residue +relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine + +[Term] +id: MOD:01830 +name: S-carboxymethyl-L-cysteine sulfone +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone." [PubMed:18688235] +synonym: "CmCO2" EXACT PSI-MOD-label [] +xref: DiffAvg: "74.03" +xref: DiffFormula: "C 2 H 2 N 0 O 3 S 0" +xref: DiffMono: "74.000394" +xref: Formula: "C 5 H 7 N 1 O 4 S 1" +xref: MassAvg: "177.17" +xref: MassMono: "177.009579" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00399 ! iodoacetic acid derivatized residue +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:01855 ! sulfur dioxygenated residue +relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine + +[Term] +id: MOD:01831 +name: S-carboxamidomethyl-L-cysteine sulfone +def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone." [PubMed:18688235] +synonym: "CamCO2" EXACT PSI-MOD-label [] +synonym: "S-carbamoylmethyl-L-cysteine sulfone" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "89.05" +xref: DiffFormula: "C 2 H 3 N 1 O 3" +xref: DiffMono: "89.011293" +xref: Formula: "C 5 H 8 N 2 O 4 S 1" +xref: MassAvg: "192.19" +xref: MassMono: "192.020478" +xref: Origin: "C" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:01855 ! sulfur dioxygenated residue +relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine + +[Term] +id: MOD:01832 +name: 5x(13)C-labeled residue +def: "A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue." [PubMed:12771378, UniMod:772] +synonym: "13C(5) Silac label" RELATED UniMod-description [] +synonym: "Label:13C(5)" RELATED PSI-MS-label [] +xref: DiffAvg: "5.02" +xref: DiffFormula: "(12)C -5 (13)C 5" +xref: DiffMono: "5.016774" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00842 ! (13)C labeled residue + +[Term] +id: MOD:01833 +name: 5x(13)C-labeled L-methionine +def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine." [PubMed:18688235, url:] +xref: DiffAvg: "5.02" +xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 0 S 0" +xref: DiffMono: "5.016774" +xref: Formula: "(13)C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "136.06" +xref: MassMono: "136.057259" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01832 ! 5x(13)C-labeled residue + +[Term] +id: MOD:01834 +name: 5x(13)C-labeled L-methionine sulfoxide +def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide." [PubMed:18688235] +xref: DiffAvg: "21.01" +xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 1 S 0" +xref: DiffMono: "21.011689" +xref: Formula: "(13)C 5 H 9 N 1 O 2 S 1" +xref: MassAvg: "152.05" +xref: MassMono: "152.052174" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00719 ! L-methionine sulfoxide +is_a: MOD:01832 ! 5x(13)C-labeled residue + +[Term] +id: MOD:01835 +name: 5x(13)C-labeled L-methionine sulfone +def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone." [PubMed:18688235] +xref: DiffAvg: "37.01" +xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 2 S 0" +xref: DiffMono: "37.006603" +xref: Formula: "(13)C 5 H 9 N 1 O 3 S 1" +xref: MassAvg: "168.05" +xref: MassMono: "168.047088" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00256 ! L-methionine sulfone +is_a: MOD:01832 ! 5x(13)C-labeled residue + +[Term] +id: MOD:01836 +name: N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine." [PubMed:18688235, PubMed:20218600, PubMed:21271704] +synonym: "(2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid" EXACT PSI-MOD-alternate [] +synonym: "[(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "237.17" +xref: DiffFormula: "C 10 H 7 N 1 O 6" +xref: DiffMono: "237.027337" +xref: Formula: "C 16 H 19 N 3 O 7" +xref: MassAvg: "365.34" +xref: MassMono: "365.122300" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00848 ! reagent derivatized residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01837 +name: L-lanthionine (Cys-Cys) +def: "A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine." [ChEBI:21347, PubMed:20805503, PubMed:6007887, RESID:AA0110#CYS2] +comment: Cross-link 2. +synonym: "(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] +synonym: "(R)-S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT RESID-alternate [] +synonym: "(R,R)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "(R,R)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate [] +synonym: "(R,R)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate [] +synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT RESID-alternate [] +synonym: "3,3'-thiobis-L-alanine" EXACT RESID-alternate [] +synonym: "L-lanthionine" EXACT RESID-name [] +xref: DiffAvg: "-34.08" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1" +xref: DiffMono: "-33.987721" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01839 ! L-lanthionine + +[Term] +id: MOD:01838 +name: L-lysinoalanine (Lys) +def: "A protein modification that effectively converts an L-lysine residue to L-lysinoalanine." [PubMed:19155267, PubMed:2544544, RESID:AA0123#LYS] +comment: This entry is for the modification of peptidyl lysine by a free serine. For the crosslink of peptidyl serine and peptidyl lysine see MOD:00132. +synonym: "(2R,9S)-lysinoalanine" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "alaninolysine" EXACT RESID-alternate [] +synonym: "L-lysinoalanine" EXACT RESID-name [] +synonym: "LAL" EXACT RESID-alternate [] +synonym: "lysino-D-alanine" EXACT RESID-alternate [] +synonym: "MOD_RES Lysino-D-alanine (Lys)" EXACT UniProt-feature [] +synonym: "N-epsilon-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] +synonym: "N6-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] +xref: DiffAvg: "87.08" +xref: DiffFormula: "C 3 H 5 N 1 O 2" +xref: DiffMono: "87.032028" +xref: Formula: "C 9 H 17 N 3 O 3" +xref: MassAvg: "215.25" +xref: MassMono: "215.126991" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01853 ! L-lysinoalanine + +[Term] +id: MOD:01839 +name: L-lanthionine +def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine." [PubMed:18688235] +comment: Cross-link 2. For the natural form of the lanthionine cross-link see MOD:00120 meso-lanthionine [JSG]. +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "C, X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:01841 ! lanthionine + +[Term] +id: MOD:01840 +name: L-allo-isoleucine +def: "A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine." [ChEBI:43433, PubMed:20805503, RESID:AA0546] +synonym: "(2S,3R)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate [] +synonym: "3-methyl-norvaline" EXACT RESID-alternate [] +synonym: "allo-L-isoleucine" EXACT RESID-alternate [] +synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate [] +synonym: "L-allo-isoleucine" EXACT RESID-name [] +synonym: "L-threo-isoleucine" EXACT RESID-alternate [] +synonym: "MOD_RES L-allo-isoleucine" EXACT UniProt-feature [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 6 H 11 N 1 O 1" +xref: MassAvg: "113.16" +xref: MassMono: "113.084064" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00910 ! modified L-isoleucine residue + +[Term] +id: MOD:01841 +name: lanthionine +def: "A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine." [PubMed:18688235] +comment: Cross-link 2. [JSG]. +synonym: "2,6-diamino-4-thiaheptanedioic acid" EXACT PSI-MOD-alternate [] +synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT PSI-MOD-alternate [] +synonym: "3,3'-thiobis-(2-aminopropanoic acid)" EXACT PSI-MOD-alternate [] +synonym: "3,3'-thiobis-L-alanine" EXACT PSI-MOD-alternate [] +synonym: "bis(2-amino-2-carboxyethyl)sulfanediyl" EXACT PSI-MOD-alternate [] +synonym: "bis(2-amino-2-carboxyethyl)sulfide" EXACT PSI-MOD-alternate [] +synonym: "S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "C, X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01993 ! beta-carbon thioether crosslinked residues + +[Term] +id: MOD:01842 +name: S-(2-aminovinyl)-L-cysteine +def: "A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine." [PubMed:20805503, RESID:AA0548] +comment: Cross-link 2. +synonym: "(2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "(R,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(2-aminovinyl)-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "-80.10" +xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1" +xref: DiffMono: "-79.993200" +xref: Formula: "C 5 H 7 N 2 O 1 S 1" +xref: MassAvg: "143.18" +xref: MassMono: "143.027909" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01851 ! S-(2-aminovinyl)-cysteine + +[Term] +id: MOD:01843 +name: 5'-chloro-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan." [PubMed:18215770, RESID:AA0549] +synonym: "(2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "5'-chloro-L-tryptophan" EXACT RESID-name [] +synonym: "MOD_RES 5'-chlorotryptophan" EXACT UniProt-feature [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 11 Cl 1 H 9 N 2 O 1" +xref: MassAvg: "220.66" +xref: MassMono: "220.040341" +xref: Origin: "W" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01913 ! monochlorinated L-tryptophan + +[Term] +id: MOD:01844 +name: 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid +def: "A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0550] +comment: Cross-link 2. +synonym: "(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate [] +synonym: "2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid" EXACT RESID-name [] +synonym: "5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic [] +synonym: "MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys)" EXACT UniProt-feature [] +xref: DiffAvg: "-5.06" +xref: DiffFormula: "C 0 H -7 N -1 O 1 S 0" +xref: DiffMono: "-5.062935" +xref: Formula: "C 9 H 10 N 1 O 3 S 1" +xref: MassAvg: "212.24" +xref: MassMono: "212.038139" +xref: Origin: "C, L" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00911 ! modified L-leucine residue +is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys) + +[Term] +id: MOD:01845 +name: L-proline 5-hydroxyoxazole-4-carbothionic acid +def: "A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0551] +comment: Cross-link 2. +synonym: "(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate [] +synonym: "5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys)" EXACT UniProt-feature [] +synonym: "L-proline 5-hydroxy-oxazole-4-carbothionic acid" EXACT RESID-name [] +xref: DiffAvg: "-4.03" +xref: DiffFormula: "C 0 H -4 N 0 O 0 S 0" +xref: DiffMono: "-4.031300" +xref: Formula: "C 8 H 8 N 2 O 2 S 1" +xref: MassAvg: "196.22" +xref: MassMono: "196.030649" +xref: Origin: "C, P" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00915 ! modified L-proline residue +is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys) + +[Term] +id: MOD:01846 +name: methanobactin OB3b copper complex +def: "A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0552] +comment: Cross-link 2. +synonym: "bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper" EXACT RESID-systematic [] +synonym: "METAL copper [Cu-methanobactin OB3b complex]" EXACT UniProt-feature [] +synonym: "methanobactin OB3b copper complex" EXACT RESID-name [] +xref: DiffAvg: "85.46" +xref: DiffFormula: "C 0 Cu 1 H -10 N 0 O 2 S 0" +xref: DiffMono: "84.841176" +xref: Formula: "C 6 Cu 1 H 0 N 2 O 4 S 2" +xref: MassAvg: "291.74" +xref: MassMono: "290.859546" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00742 ! copper containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01847 +name: L-cysteine sulfinyl phosphate +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate." [PubMed:16565085, RESID:AA0557] +synonym: "(2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid" EXACT RESID-systematic [] +synonym: "cysteine sulfinic phosphoryl ester" EXACT RESID-alternate [] +synonym: "L-cysteine sulfinyl phosphate" EXACT RESID-name [] +xref: DiffAvg: "111.98" +xref: DiffFormula: "C 0 H 1 N 0 O 5 P 1 S 0" +xref: DiffMono: "111.956160" +xref: Formula: "C 3 H 6 N 1 O 6 P 1 S 1" +xref: MassAvg: "215.12" +xref: MassMono: "214.965345" +xref: Origin: "C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00708 ! sulfur oxygenated L-cysteine +is_a: MOD:00861 ! phosphorus containing modified residue + +[Term] +id: MOD:01848 +name: S-(spermidinoglutathion-S-yl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine." [ChEBI:16613, PubMed:20530482, RESID:AA0558] +synonym: "(2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "cysteine glutathionylspermidine disulfide" EXACT RESID-alternate [] +synonym: "L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide" EXACT RESID-alternate [] +synonym: "S-(spermidinoglutathion-S-yl)-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "432.54" +xref: DiffFormula: "C 17 H 32 N 6 O 5 S 1" +xref: DiffMono: "432.215489" +xref: Formula: "C 20 H 37 N 7 O 6 S 2" +xref: MassAvg: "535.68" +xref: MassMono: "535.224674" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01862 ! disulfide conjugated residue + +[Term] +id: MOD:01849 +name: S-(2-aminovinyl)-D-cysteine (Cys-Cys) +def: "A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [PubMed:20805503, RESID:AA0204#CYS2] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] +synonym: "CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys)" EXACT UniProt-feature [] +synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name [] +xref: DiffAvg: "-80.10" +xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1" +xref: DiffMono: "-79.993200" +xref: Formula: "C 5 H 7 N 2 O 1 S 1" +xref: MassAvg: "143.18" +xref: MassMono: "143.027909" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01850 ! S-(2-aminovinyl)-D-cysteine + +[Term] +id: MOD:01850 +name: S-(2-aminovinyl)-D-cysteine +def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [RESID:AA0204] +comment: Cross-link 2. +synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 7 N 2 O 1 S 1" +xref: MassAvg: "143.18" +xref: MassMono: "143.027909" +xref: Origin: "C, X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:01851 ! S-(2-aminovinyl)-cysteine + +[Term] +id: MOD:01851 +name: S-(2-aminovinyl)-cysteine +def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine." [PubMed:18688235] +comment: Cross-link 2. +synonym: "2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 5 H 7 N 2 O 1 S 1" +xref: MassAvg: "143.18" +xref: MassMono: "143.027909" +xref: Origin: "C, X" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00687 ! thioether crosslinked residues +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01852 +name: L-lysinoalanine (Lys-Cys) +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid." [DeltaMass:0] +comment: Cross-link 2. This entry is for a crosslink of peptidyl cysteine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34 with no citation or formula. [JSG] +synonym: "Lysinoalanine (from Cysteine)" EXACT DeltaMass-label [] +xref: DiffAvg: "-34.08" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1" +xref: DiffMono: "-33.987721" +xref: Formula: "C 9 H 15 N 3 O 2" +xref: MassAvg: "197.24" +xref: MassMono: "197.116427" +xref: Origin: "C, K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01853 ! L-lysinoalanine + +[Term] +id: MOD:01853 +name: L-lysinoalanine +def: "A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine." [PubMed:18688235] +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01854 +name: sulfur monooxygenated residue +def: "A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00680 ! sulfur oxygenated residue + +[Term] +id: MOD:01855 +name: sulfur dioxygenated residue +def: "A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:00680 ! sulfur oxygenated residue + +[Term] +id: MOD:01856 +name: oxazole/oxazoline ring crosslinked residues (Cys) +def: "A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid." [PubMed:18688235] +is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues + +[Term] +id: MOD:01857 +name: 2-(L-cystein-S-yl)-methionine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine." [PubMed:20805502, RESID:AA0559] +comment: Cross-link 2. The chirality around the methionine alpha-carbon has not been determined. +synonym: "(2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-(L-cystein-S-yl)-methionine" EXACT RESID-name [] +synonym: "CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met)" EXACT UniProt-feature [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 8 H 12 N 2 O 2 S 2" +xref: MassAvg: "232.32" +xref: MassMono: "232.034020" +xref: Origin: "C, M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01858 +name: S-(N-acetylamino)glucosyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine." [ChEBI:61631, PubMed:21251913, PubMed:21395300, RESID:AA0560] +synonym: "(2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD S-linked (GlcNAc)" EXACT UniProt-feature [] +synonym: "S-(N-acetylamino)glucosyl-L-cysteine" EXACT RESID-name [] +synonym: "S-[(N-acetylamino)glycosyl]cysteine" EXACT RESID-alternate [] +synonym: "S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5 S 0" +xref: DiffMono: "203.079373" +xref: Formula: "C 11 H 18 N 2 O 6 S 1" +xref: MassAvg: "306.33" +xref: MassMono: "306.088557" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00426 ! S-glycosylated residue +is_a: MOD:00448 ! N-acetylaminoglucosylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01859 +name: 4-amino-3-isothiazolidinone-L-phenylalanine +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine." [PubMed:17502599, RESID:AA0562] +comment: Cross-link 2. +synonym: "(2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid" EXACT RESID-alternate [] +synonym: "4-amino-3-isothiazolidinone-L-phenylalanine" EXACT RESID-alternate [] +synonym: "CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe)" EXACT UniProt-feature [] +synonym: "cysteinyl phenylalanine sulfenamide" EXACT RESID-alternate [] +synonym: "N,N-(L-cysteine-1,S-diyl)-L-phenylalanine" EXACT RESID-name [] +synonym: "phenylalanine-cysteine sulfenyl amide cross-link" EXACT RESID-alternate [] +synonym: "phenylalanine-cysteine sulphenyl amide cross-link" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 12 H 12 N 2 O 2 S 1" +xref: MassAvg: "248.30" +xref: MassMono: "248.061949" +xref: Origin: "C, F" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:01861 ! isothiazolidinone ring crosslinked residues + +[Term] +id: MOD:01860 +name: L-cysteine bacillithiol disulfide +def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide." [ChEBI:61338, PubMed:19578333, RESID:AA0563] +synonym: "(2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid" EXACT RESID-systematic [] +synonym: "BSH" EXACT RESID-alternate [] +synonym: "L-cysteine bacillithiol disulfide" EXACT RESID-name [] +synonym: "MOD_RES S-bacillithiol cysteine disulfide" EXACT UniProt-feature [] +xref: DiffAvg: "396.37" +xref: DiffFormula: "C 13 H 20 N 2 O 10 S 1" +xref: DiffMono: "396.083866" +xref: Formula: "C 16 H 25 N 3 O 11 S 2" +xref: MassAvg: "499.51" +xref: MassMono: "499.093051" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01862 ! disulfide conjugated residue + +[Term] +id: MOD:01861 +name: isothiazolidinone ring crosslinked residues +def: "A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring." [PubMed:18688235] +comment: The isothiazolidinone ring is usually formed by the reaction of a cysteine sulfenic acid with the amido nitrogen releasing water. +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:01862 +name: disulfide conjugated residue +def: "A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "S-thiolation" EXACT PSI-MOD-alternate [] +xref: Origin: "C" +xref: TermSpec: "none" +is_a: MOD:01886 ! thiolated residue + +[Term] +id: MOD:01863 +name: mTRAQ reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups." [PubMed:18688235] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01426 ! isotope tagged reagent derivatized residue +is_a: MOD:01705 ! isotope tagged reagent acylated residue + +[Term] +id: MOD:01864 +name: mTRAQ light reporter+balance reagent acylated residue +def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group." [UniMod:888] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "mTRAQ heavy" RELATED UniMod-description [] +xref: DiffAvg: "140.09" +xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" +xref: DiffMono: "140.094963" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01863 ! mTRAQ reporter+balance reagent acylated residue +is_a: MOD:01868 ! modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da + +[Term] +id: MOD:01865 +name: mTRAQ light reporter+balance reagent acylated N-terminal +def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:208, UniMod:888#N-term] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "mTRAQ light" RELATED UniMod-description [] +synonym: "mTRAQ light on nterm" EXACT OMSSA-label [] +xref: DiffAvg: "140.09" +xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" +xref: DiffMono: "140.094963" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue + +[Term] +id: MOD:01866 +name: mTRAQ light reporter+balance reagent N6-acylated lysine +def: "A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:209, UniMod:888#K] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +subset: PSI-MOD-slim +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "mTRAQ light" RELATED UniMod-description [] +synonym: "mTRAQ light on K" EXACT OMSSA-label [] +xref: DiffAvg: "140.09" +xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" +xref: DiffMono: "140.094963" +xref: Formula: "(12)C 13 H 24 N 2 (14)N 2 O 1 (16)O 1" +xref: MassAvg: "268.19" +xref: MassMono: "268.189926" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01867 +name: mTRAQ light reporter+balance reagent O4'-acylated tyrosine +def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:210, UniMod:888#Y] +comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. +synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] +synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] +synonym: "mTRAQ light" RELATED UniMod-description [] +synonym: "mTRAQ light on Y" EXACT OMSSA-label [] +xref: DiffAvg: "140.09" +xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" +xref: DiffMono: "140.094963" +xref: Formula: "(12)C 16 H 21 (14)N 3 O 2 (16)O 1" +xref: MassAvg: "303.16" +xref: MassMono: "303.158292" +xref: Origin: "Y" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue + +[Term] +id: MOD:01868 +name: modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da +def: "Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da + +[Term] +id: MOD:01869 +name: mTRAQ light reporter fragment +def: "The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: FormalCharge: "1+" +xref: Formula: "(12)C 6 H 13 (14)N 2" +xref: MassAvg: "113.11" +xref: MassMono: "113.107325" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01870 ! mTRAQ reporter fragment +relationship: derives_from MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue + +[Term] +id: MOD:01870 +name: mTRAQ reporter fragment +def: "A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue." [PubMed:18688235] +subset: PSI-MOD-slim +is_a: MOD:01520 ! modification reporter fragment + +[Term] +id: MOD:01871 +name: cyclized N-terminal S-carboxamidomethyl-L-cysteine +def: "A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia." [DeltaMass:336, PubMed:12643538, UniMod:26] +subset: PSI-MOD-slim +synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label [] +synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate [] +synonym: "Otc" EXACT DeltaMass-label [] +synonym: "Pyro-carbamidomethyl" RELATED UniMod-interim [] +synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED UniMod-description [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 5 H 6 N 1 O 2 S 1" +xref: MassAvg: "144.17" +xref: MassMono: "144.011924" +xref: Origin: "MOD:01060" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00397 ! iodoacetamide derivatized residue +is_a: MOD:00419 ! (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid +relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine + +[Term] +id: MOD:01872 +name: cyclized N-terminal S-carboxymethyl-L-cysteine +def: "A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water." [PubMed:12643538, UniMod:26] +comment: Contrary to the impression given in UniMod entry 26, the cyclization of N-terminal S-carboxymethyl-L-cysteine is not reported in PubMed:1263538. The cyclization would be expected to proceed under strongly acidic conditions [JSG]. +subset: PSI-MOD-slim +synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label [] +synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate [] +synonym: "Otc" EXACT DeltaMass-label [] +synonym: "Pyro-carbamidomethyl" RELATED UniMod-interim [] +synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED UniMod-description [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 5 H 6 N 1 O 2 S 1" +xref: MassAvg: "144.17" +xref: MassMono: "144.011924" +xref: Origin: "MOD:01061" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00399 ! iodoacetic acid derivatized residue +is_a: MOD:00419 ! (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid +relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine + +[Term] +id: MOD:01873 +name: N-carboxy-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine." [PubMed:18688235, PubMed:4593770, PubMed:4647257, PubMed:8312270] +comment: This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. +synonym: "(S)-2-carboxyamino-propanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-carbamic-propanoic acid" EXACT PSI-MOD-alternate [] +synonym: "N-carboxymethionine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "C 4 H 6 N 1 O 3" +xref: MassAvg: "116.10" +xref: MassMono: "116.034768" +xref: Origin: "A" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:01874 +name: N-carboxy-L-valine +def: "A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine." [PubMed:18688235, PubMed:4593770, PubMed:4647257, PubMed:8312270] +comment: This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. +synonym: "(S)-2-carboxyamino-propanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-carbamic-propanoic acid" EXACT PSI-MOD-alternate [] +synonym: "N-carboxymethionine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "44.01" +xref: DiffFormula: "C 1 H 0 N 0 O 2" +xref: DiffMono: "43.989829" +xref: Formula: "C 6 H 10 N 1 O 3" +xref: MassAvg: "144.15" +xref: MassMono: "144.066068" +xref: Origin: "V" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00920 ! modified L-valine residue +is_a: MOD:01152 ! carboxylated residue + +[Term] +id: MOD:01875 +name: N6-acylated L-lysine +def: "A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "N6AcylLys" EXACT PSI-MOD-label [] +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00670 ! N-acylated residue +is_a: MOD:00912 ! modified L-lysine residue + +[Term] +id: MOD:01876 +name: 4x(1)H,4x(12)C-labeled alpha-amino succinylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(12)C labeled succinyl group." [PubMed:11857757, PubMed:12175151, PubMed:12716131, UniMod:64] +synonym: "Succinic anhydride labeling reagent, light form (+4amu, 4H2) site N-term" RELATED UniMod-description [] +synonym: "Succinyl" RELATED PSI-MS-label [] +xref: DiffAvg: "100.02" +xref: DiffFormula: "(12)C 4 (1)H 4 O 3" +xref: DiffMono: "100.016044" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00457 ! alpha-amino succinylated residue +is_a: MOD:01426 ! isotope tagged reagent derivatized residue + +[Term] +id: MOD:01877 +name: 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid +def: "A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid." [PubMed:20961038, RESID:AA0553] +comment: Cross-link 2. +synonym: "(4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole" EXACT RESID-alternate [] +synonym: "2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid" EXACT RESID-systematic [] +synonym: "2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer]" EXACT RESID-alternate [] +synonym: "2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid" EXACT RESID-name [] +synonym: "CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys)" EXACT UniProt-feature [] +xref: DiffAvg: "-6.05" +xref: DiffFormula: "C 0 H -6 N 0 O 0 S 0" +xref: DiffMono: "-6.046950" +xref: Formula: "C 9 H 12 N 5 O 2 S 1" +xref: MassAvg: "254.29" +xref: MassMono: "254.071171" +xref: Origin: "C, R" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01883 ! 5-imidazolinone ring crosslinked residues (Cys) + +[Term] +id: MOD:01878 +name: L-threonine 5-hydroxyoxazole-4-carbonthionic acid +def: "A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid." [PubMed:20961038, RESID:AA0554] +comment: Cross-link 2. +synonym: "(4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate [] +synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys)" EXACT UniProt-feature [] +synonym: "L-threonine 5-hydroxy-oxazole-4-carbonthionic acid" EXACT RESID-name [] +xref: DiffAvg: "-4.03" +xref: DiffFormula: "C 0 H -4 N 0 O 0 S 0" +xref: DiffMono: "-4.031300" +xref: Formula: "C 7 H 8 N 2 O 3 S 1" +xref: MassAvg: "200.21" +xref: MassMono: "200.025563" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys) + +[Term] +id: MOD:01879 +name: methanobactin SB2 copper complex +def: "A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex." [PubMed:20961038, RESID:AA0555] +comment: Cross-link 2. +synonym: "[5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper" EXACT RESID-systematic [] +synonym: "METAL copper [Cu-methanobactin SB2 complex]" EXACT UniProt-feature [] +synonym: "methanobactin SB2 copper complex" EXACT RESID-name [] +xref: DiffAvg: "84.48" +xref: DiffFormula: "C 0 Cu 1 H -9 N 1 O 1 S 0" +xref: DiffMono: "83.857161" +xref: Formula: "C 6 Cu 1 H 1 N 3 O 3 S 2" +xref: MassAvg: "290.76" +xref: MassMono: "289.875530" +xref: Origin: "C, C, R, T" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00742 ! copper containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01880 +name: L-deoxyhypusine +def: "modification from RESID" [ChEBI:50038, PubMed:16452303, RESID:AA0564] +synonym: "(2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid" EXACT RESID-systematic [] +synonym: "deoxyhypusine" EXACT RESID-alternate [] +synonym: "L-deoxyhypusine" EXACT RESID-name [] +synonym: "N6-(4-aminobutyl)lysine" EXACT RESID-alternate [] +xref: DiffAvg: "71.12" +xref: DiffFormula: "C 4 H 9 N 1 O 0" +xref: DiffMono: "71.073499" +xref: Formula: "C 10 H 21 N 3 O 1" +xref: MassAvg: "199.30" +xref: MassMono: "199.168462" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01884 ! 4-aminobutylated residue + +[Term] +id: MOD:01881 +name: 3-(L-phenylalan-2'-yl)-L-valine +def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine." [PubMed:21596985, RESID:AA0565] +comment: Cross-link 2. +synonym: "(2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid" EXACT RESID-systematic [] +synonym: "3-(L-phenylalan-2'-yl)-L-valine" EXACT RESID-name [] +synonym: "symerythrin valine-phenylalanine cross-link" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 14 H 16 N 2 O 2" +xref: MassAvg: "244.29" +xref: MassMono: "244.121178" +xref: Origin: "F, V" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00692 ! uncategorized crosslinked residues +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:00920 ! modified L-valine residue + +[Term] +id: MOD:01882 +name: 5-imidazolinone ring crosslinked residues (Gly) +def: "A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring." [PubMed:18688235] +is_a: MOD:00691 ! 5-imidazolinone ring crosslinked residues + +[Term] +id: MOD:01883 +name: 5-imidazolinone ring crosslinked residues (Cys) +def: "A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring." [PubMed:18688235] +is_a: MOD:00691 ! 5-imidazolinone ring crosslinked residues + +[Term] +id: MOD:01884 +name: 4-aminobutylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00001 ! alkylated residue + +[Term] +id: MOD:01885 +name: biotinylated residue +def: "A protein modification that effectively replaces a hydrogen atom with a biotinyl group." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl" EXACT PSI-MOD-alternate [] +synonym: "Biotinylation" EXACT PSI-MOD-alternate [] +synonym: "BtnRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "226.29" +xref: DiffFormula: "C 10 H 14 N 2 O 2 S 1" +xref: DiffMono: "226.077599" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:01886 +name: thiolated residue +def: "A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group." [PubMed:18688235] +subset: PSI-MOD-slim +xref: Origin: "X" +xref: TermSpec: "none" +is_a: MOD:00860 ! sulfur containing modified residue + +[Term] +id: MOD:01887 +name: Uniblue A derivatized lysine +def: "A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] +synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] +synonym: "N6UniblueALys" EXACT PSI-MOD-label [] +synonym: "Uniblue A" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "484.50" +xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2" +xref: DiffMono: "484.039893" +xref: Formula: "C 28 H 28 N 4 O 8 S 2" +xref: MassAvg: "612.67" +xref: MassMono: "612.134856" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01659 ! Uniblue A derivatized residue + +[Term] +id: MOD:01888 +name: didehydrogenated residue +def: "A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue." [UniMod:401] +subset: PSI-MOD-slim +synonym: "2dHRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0" +xref: DiffMono: "-2.015650" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00683 ! dehydrogenated residue + +[Term] +id: MOD:01889 +name: S-(2-succinyl)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid." [PubMed:16624247, PubMed:18448829, PubMed:20677745, RESID:AA0561, UniMod:957] +synonym: "(2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "(2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid" EXACT RESID-alternate [] +synonym: "2-((2-amino-2-carboxyethyl)thio)butanedioic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-(1,2-dicarboxyethylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "S-(1,2-dicarboxyethyl)cysteine" EXACT RESID-alternate [] +synonym: "S-(2-succinyl)-L-cysteine" EXACT RESID-name [] +synonym: "S-(2-succinyl)cysteine" EXACT RESID-alternate [] +synonym: "S-[(2R)-2-succinyl]-L-cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "116.07" +xref: DiffFormula: "C 4 H 4 N 0 O 4 S 0" +xref: DiffMono: "116.010959" +xref: Formula: "C 7 H 9 N 1 O 5 S 1" +xref: MassAvg: "219.21" +xref: MassMono: "219.020143" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00001 ! alkylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01890 +name: N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) +def: "A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine." [PubMed:19622680, RESID:AA0566#FMET] +comment: Cross-link 2. +synonym: "(2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "N-[(L-histidin-1'-yl)methyl]-L-methionine" EXACT RESID-name [] +xref: DiffAvg: "-16.00" +xref: DiffFormula: "C 0 H 0 N 0 O -1 S 0" +xref: DiffMono: "-15.994915" +xref: Formula: "C 12 H 17 N 4 O 2 S 1" +xref: MassAvg: "281.35" +xref: MassMono: "281.107222" +xref: Origin: "H, MOD:00030" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01450 ! modified N-formyl-L-methionine residue + +[Term] +id: MOD:01891 +name: N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) +def: "A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine." [PubMed:19622680, RESID:AA0566#MET] +comment: Cross-link 2. +synonym: "(2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "N-[(L-histidin-1'-yl)methyl]-L-methionine" EXACT RESID-name [] +xref: DiffAvg: "12.01" +xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0" +xref: DiffMono: "12.000000" +xref: Formula: "C 12 H 17 N 4 O 2 S 1" +xref: MassAvg: "281.35" +xref: MassMono: "281.107222" +xref: Origin: "H, M" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:01892 +name: N6-crotonyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine." [PubMed:21925322, RESID:AA0567] +synonym: "(2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N6-crotonyl-L-lysine" EXACT UniProt-feature [] +synonym: "N(epsilon)-crotonyllysine" EXACT RESID-alternate [] +synonym: "N6-(E)-crotonyllysine" EXACT RESID-alternate [] +synonym: "N6-[(2E)-2-butenoyl]-L-lysine" EXACT RESID-alternate [] +synonym: "N6-crotonyl-L-lysine" EXACT RESID-name [] +synonym: "N6-crotonyllysine" EXACT RESID-alternate [] +synonym: "N6-trans-crotonyllysine" EXACT RESID-alternate [] +xref: DiffAvg: "68.07" +xref: DiffFormula: "C 4 H 4 N 0 O 1" +xref: DiffMono: "68.026215" +xref: Formula: "C 10 H 16 N 2 O 2" +xref: MassAvg: "196.25" +xref: MassMono: "196.121178" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01893 +name: N6-malonyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine." [PubMed:21908771, PubMed:8349414, RESID:AA0568] +synonym: "(2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid" EXACT RESID-systematic [] +synonym: "2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid" EXACT RESID-alternate [] +synonym: "malonyllysine" EXACT RESID-alternate [] +synonym: "MOD_RES N6-malonyllysine" EXACT UniProt-feature [] +synonym: "N(epsilon)-(malonyl)lysine" EXACT RESID-alternate [] +synonym: "N6-(carboxyacetyl)lysine" EXACT RESID-alternate [] +synonym: "N6-malonyl-L-lysine" EXACT RESID-name [] +synonym: "N6-malonyllysine" EXACT RESID-alternate [] +xref: DiffAvg: "86.05" +xref: DiffFormula: "C 3 H 2 N 0 O 3" +xref: DiffMono: "86.000394" +xref: Formula: "C 9 H 14 N 2 O 4" +xref: MassAvg: "214.22" +xref: MassMono: "214.095357" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01894 +name: propanoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58] +synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] +synonym: "Propionyl" RELATED PSI-MS-label [] +xref: DiffAvg: "56.06" +xref: DiffFormula: "C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:01895 +name: alpha-amino 3x(12)C-labeled propanoylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58#N-term] +synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] +synonym: "Propionyl" RELATED PSI-MS-label [] +xref: DiffAvg: "56.03" +xref: DiffFormula: "(12)C 3 H 4 O 1" +xref: DiffMono: "56.026215" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00451 ! alpha-amino propanoylated residue + +[Term] +id: MOD:01896 +name: trifluoroacetic acid adduct +def: "A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue." [PubMed:18688235] +comment: Trifluoroacetic acid has been observed to form adducts in both negative and positive mode analysis (Mark Collins, private communication) [JSG]. +synonym: "TFA" EXACT DeltaMass-label [] +xref: DiffAvg: "114.02" +xref: DiffFormula: "C 2 F 3 H 1 O 2" +xref: DiffMono: "113.992864" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00498 ! fluorinated residue +is_a: MOD:00848 ! reagent derivatized residue + +[Term] +id: MOD:01897 +name: 5-hydroxy-3-methyl-L-proline (Ile) +def: "A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline." [PubMed:21788474, PubMed:7592021, PubMed:8557573, RESID:AA0473] +synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name [] +synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate [] +synonym: "5Hy3MePro(Ile)" EXACT PSI-MOD-label [] +synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate [] +synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature [] +xref: DiffAvg: "13.98" +xref: DiffFormula: "C 0 H -2 N 0 O 1" +xref: DiffMono: "13.979265" +xref: Formula: "C 6 H 9 N 1 O 2" +xref: MassAvg: "127.14" +xref: MassMono: "127.063329" +xref: Origin: "I" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00679 ! carbon oxygenated residue +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:01888 ! didehydrogenated residue +is_a: MOD:01905 ! 5-hydroxy-3-methyl-L-proline + +[Term] +id: MOD:01898 +name: N2,N2-dimethyl-L-arginine +def: "modification from RESID" [PubMed:21568297, PubMed:21950656, RESID:AA0569] +synonym: "(2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "MOD_RES N2,N2-dimethylarginine" EXACT UniProt-feature [] +synonym: "N(alpha),N(alpha)-dimethylarginine" EXACT RESID-alternate [] +synonym: "N2,N2-dimethyl-L-arginine" EXACT RESID-name [] +synonym: "N2,N2-dimethylarginine" EXACT RESID-alternate [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 8 H 17 N 4 O 1" +xref: MassAvg: "185.25" +xref: MassMono: "185.140236" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00783 ! dimethylated L-arginine + +[Term] +id: MOD:01899 +name: L-arginine thiazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0570] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys)" EXACT UniProt-feature [] +synonym: "L-arginine thiazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 9 H 13 N 5 O 1 S 1" +xref: MassAvg: "239.30" +xref: MassMono: "239.084081" +xref: Origin: "C, R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00902 ! modified L-arginine residue +is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01900 +name: L-cysteine 5-methyloxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0571] +comment: Cross-link 2. +synonym: "2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr)" EXACT UniProt-feature [] +synonym: "L-cysteine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" +xref: DiffMono: "-20.026215" +xref: Formula: "C 7 H 8 N 2 O 2 S 1" +xref: MassAvg: "184.21" +xref: MassMono: "184.030649" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01901 +name: L-threonine 5-methyloxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0572] +comment: Cross-link 2. +synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr)" EXACT UniProt-feature [] +synonym: "L-threonine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 8 H 10 N 2 O 3" +xref: MassAvg: "182.18" +xref: MassMono: "182.069142" +xref: Origin: "T, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01902 +name: L-isoleucine oxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0573] +comment: Cross-link 2. +synonym: "2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser)" EXACT UniProt-feature [] +synonym: "L-isoleucine oxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 9 H 12 N 2 O 2" +xref: MassAvg: "180.21" +xref: MassMono: "180.089878" +xref: Origin: "I, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00910 ! modified L-isoleucine residue +is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01903 +name: L-serine oxazole-4-carboxylic acid +def: "A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0574] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser)" EXACT UniProt-feature [] +synonym: "L-serine oxazole-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-20.03" +xref: DiffFormula: "C 0 H -4 N 0 O -1" +xref: DiffMono: "-20.026215" +xref: Formula: "C 6 H 6 N 2 O 3" +xref: MassAvg: "154.13" +xref: MassMono: "154.037842" +xref: Origin: "S, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) +is_a: MOD:01888 ! didehydrogenated residue + +[Term] +id: MOD:01904 +name: L-serine 5-methyloxazoline-4-carboxylic acid +def: "A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0575] +comment: Cross-link 2. +synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr)" EXACT UniProt-feature [] +synonym: "L-serine 5-methyloxazoline-4-carboxylic acid" EXACT RESID-name [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 10 N 2 O 3" +xref: MassAvg: "170.17" +xref: MassMono: "170.069142" +xref: Origin: "S, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) + +[Term] +id: MOD:01905 +name: 5-hydroxy-3-methyl-L-proline +def: "A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline." [PubMed:7592021, PubMed:8557573, RESID:AA0473] +synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name [] +synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate [] +synonym: "5Hy3MePro" EXACT PSI-MOD-label [] +synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate [] +synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 9 N 1 O 2" +xref: MassAvg: "127.14" +xref: MassMono: "127.063329" +xref: Origin: "X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +relationship: has_functional_parent MOD:01024 ! monohydroxylated proline + +[Term] +id: MOD:01906 +name: dehydromethionine +def: "A protein modification that effectively converts an L-methionine residue to dehydromethionine." [PubMed:18688235, PubMed:19775156] +synonym: "(3S)-3-carboxy-1-methylisothiazolidin-1-ium" EXACT PSI-MOD-alternate [] +synonym: "L-dehydromethionine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-1.01" +xref: DiffFormula: "C 0 H -1 N 0 O 0 S 0" +xref: DiffMono: "-1.008374" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "131.19" +xref: MassMono: "131.039936" +xref: Origin: "M" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00913 ! modified L-methionine residue + +[Term] +id: MOD:01907 +name: dehydromethionine (from L-methioninium) +def: "A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine." [PubMed:18688235, PubMed:19775156] +comment: This process accounts only for cyclizaation and not protonation. The alternative process (MOD:01906) accounts for both protonation and cyclization. +synonym: "(3S)-3-carboxy-1-methylisothiazolidin-1-ium" EXACT PSI-MOD-alternate [] +synonym: "L-dehydromethionine" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.016199" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 9 N 1 O 1 S 1" +xref: MassAvg: "131.19" +xref: MassMono: "131.039936" +xref: Origin: "MOD:001464" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:00601 ! cyclized residue +is_a: MOD:00913 ! modified L-methionine residue +relationship: derives_from MOD:01464 ! protonated L-methionine (L-methioninium) residue + +[Term] +id: MOD:01908 +name: 4-sulfophenyl isothiocyanate alpha-amino derivatized residue +def: "A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue." [PubMed:14689565, PubMed:14745769, PubMed:15549660, PubMed:16526082, UniMod:261#N-term] +synonym: "4-sulfophenyl isothiocyanate" RELATED UniMod-description [] +synonym: "alpha-amino-[(4-sulfophenyl)carbamothioyl] residue" EXACT PSI-MOD-alternate [] +synonym: "SPITC" RELATED PSI-MS-label [] +xref: DiffAvg: "215.24" +xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" +xref: DiffMono: "214.971085" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue + +[Term] +id: MOD:01909 +name: 6x(13)C labeled 4-sulfophenyl isothiocyanate alpha-amino derivatized residue +def: "A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue." [PubMed:11467524, PubMed:16526082, UniMod:464#N-term] +synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED UniMod-description [] +synonym: "SPITC:13C(6)" RELATED PSI-MS-label [] +xref: DiffAvg: "220.99" +xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2" +xref: DiffMono: "220.991214" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00880 ! 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue + +[Term] +id: MOD:01910 +name: monofluorinated residue +def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom." [UniMod:127] +synonym: "F1Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "17.99" +xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" +xref: DiffMono: "17.990578" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00498 ! fluorinated residue + +[Term] +id: MOD:01911 +name: monochlorinated residue +def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom." [UniMod:936] +synonym: "Cl1Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00753 ! chlorinated residue + +[Term] +id: MOD:01912 +name: monobrominated residue +def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom." [UniMod:340] +synonym: "Br1Res" EXACT PSI-MOD-label [] +xref: DiffAvg: "78.90" +xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" +xref: DiffMono: "77.910512" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00754 ! brominated residue + +[Term] +id: MOD:01913 +name: monochlorinated L-tryptophan +def: "A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom." [PubMed:18688235] +synonym: "Cl1Trp" EXACT PSI-MOD-label [] +xref: DiffAvg: "34.44" +xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" +xref: DiffMono: "33.961028" +xref: Formula: "C 11 Cl 1 H 9 N 2 O 1" +xref: MassAvg: "220.66" +xref: MassMono: "220.040341" +xref: Origin: "W" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:01068 ! halogenated tryptophan +is_a: MOD:01911 ! monochlorinated residue + +[Term] +id: MOD:01914 +name: O5-galactosyl-L-hydroxylysine +def: "A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine." [PMID:743239, PubMed:17516569, UniMod:907] +comment: Secondary to RESID:AA0028. This intermediate is rarely observed [JSG]. +subset: PSI-MOD-slim +synonym: "Galactosyl hydroxylysine" RELATED UniMod-description [] +synonym: "OGal5HyLys" EXACT PSI-MOD-label [] +xref: DiffAvg: "178.14" +xref: DiffFormula: "C 6 H 10 N 0 O 6" +xref: DiffMono: "178.047738" +xref: Formula: "C 16 H 22 N 2 O 7" +xref: MassAvg: "354.36" +xref: MassMono: "354.142701" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00037 ! 5-hydroxy-L-lysine +is_a: MOD:00396 ! O-glycosylated residue +is_a: MOD:00476 ! galactosylated residue + +[Term] +id: MOD:01915 +name: N-formyl-L-alanine +def: "A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine." [PubMed:9334739, RESID:AA0576] +synonym: "(2S)-2-(formylamino)propanoic acid" EXACT RESID-systematic [] +synonym: "2-formamidopropanoic acid" EXACT RESID-alternate [] +synonym: "2-formamidopropionic acid" EXACT RESID-alternate [] +synonym: "N-formyl-L-alanine" EXACT RESID-name [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 4 H 6 N 1 O 2" +xref: MassAvg: "100.10" +xref: MassMono: "100.039853" +xref: Origin: "A" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00409 ! N-formylated residue +is_a: MOD:00901 ! modified L-alanine residue + +[Term] +id: MOD:01916 +name: O4'-(N-acetylamino)galactosyl-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine." [PubMed:21712440, PubMed:21983924, RESID:AA0577] +synonym: "(2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid" EXACT RESID-systematic [] +synonym: "CARBOHYD O-linked (GalNAc)" EXACT UniProt-feature [] +synonym: "mucin type O-glycosyltyrosine" EXACT RESID-alternate [] +synonym: "O4'-(N-acetylamino)galactosyl-L-tyrosine" EXACT RESID-name [] +synonym: "O4'-(N-acetylgalactosaminyl)tyrosine" EXACT RESID-alternate [] +synonym: "O4'-glycosyl-L-tyrosine" EXACT RESID-alternate [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 17 H 22 N 2 O 7" +xref: MassAvg: "366.37" +xref: MassMono: "366.142701" +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00563 ! N-acetylaminogalactosylated residue +is_a: MOD:01927 ! O-glycosyl-L-tyrosine + +[Term] +id: MOD:01917 +name: N6-(L-isoaspartyl)-L-lysine (Asp) +def: "A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water." [ChEBI:21862, PubMed:11000116, PubMed:15044436, PubMed:18063798, PubMed:6503713, RESID:AA0294#ASP] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature [] +synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate [] +synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name [] +synonym: "XLNK-4Asp-N6Lys(Asp)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 10 H 15 N 3 O 3" +xref: MassAvg: "225.25" +xref: MassMono: "225.111341" +xref: Origin: "D, K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01929 ! N6-(L-isoaspartyl)-L-lysine + +[Term] +id: MOD:01918 +name: (2S,5S)-5-hydroxylysine +def: "A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine." [PubMed:19574390, PubMed:22238144, RESID:AA0578] +subset: PSI-MOD-slim +synonym: "(2S,5S)-2,6-diamino-5-hydroxyhexanoic acid" EXACT RESID-systematic [] +synonym: "(2S,5S)-5-hydroxylysine" EXACT RESID-name [] +synonym: "2,6-bisazanyl-5-hydroxyhexanoic acid" EXACT RESID-alternate [] +synonym: "2,6-diamino-2,3,4,6-tetradeoxyhexonic acid" EXACT RESID-alternate [] +synonym: "alpha,epsilon-diamino-delta-hydroxycaproic acid" EXACT RESID-alternate [] +synonym: "L-allo-delta-hydroxylysine" EXACT RESID-alternate [] +synonym: "L-threo-delta-hydroxylysine" EXACT RESID-alternate [] +synonym: "MOD_RES (5S)-5-hydroxylysine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 2 O 2" +xref: MassAvg: "144.17" +xref: MassMono: "144.089878" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00037 ! 5-hydroxy-L-lysine + +[Term] +id: MOD:01919 +name: (2S,3S)-3-hydroxyaspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid." [ChEBI:10696, PubMed:21177872, RESID:AA0579] +subset: PSI-MOD-slim +synonym: "(2S,3S)-2-amino-3-hydroxybutanedioic acid" EXACT RESID-systematic [] +synonym: "(2S,3S)-3-hydroxyaspartic acid" EXACT RESID-name [] +synonym: "(3S)-3-hydroxy-L-aspartic acid" EXACT RESID-alternate [] +synonym: "2-amino-3-hydroxysuccinic acid" EXACT RESID-alternate [] +synonym: "2-azanyl-3-hydroxybutanedioic acid" EXACT RESID-alternate [] +synonym: "3-hydroxyaspartic acid" EXACT RESID-alternate [] +synonym: "L-threo-3-hydroxyaspartic acid" EXACT RESID-alternate [] +synonym: "L-threo-beta-hydroxyaspartic acid" EXACT RESID-alternate [] +synonym: "MOD_RES (3S)-3-hydroxyaspartate" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 4 H 5 N 1 O 4" +xref: MassAvg: "131.09" +xref: MassMono: "131.021858" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01926 ! 3-hydroxy-L-aspartic acid + +[Term] +id: MOD:01920 +name: 3-hydroxy-L-histidine +def: "A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine." [PubMed:21251231, RESID:AA0580] +synonym: "(2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] +synonym: "3-hydroxy-L-histidine" EXACT RESID-name [] +synonym: "MOD_RES 3-hydroxyhistidine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 7 N 3 O 2" +xref: MassAvg: "153.14" +xref: MassMono: "153.053826" +xref: Origin: "H" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00677 ! hydroxylated residue + +[Term] +id: MOD:01921 +name: D-aspartic acid (Asp) +def: "A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190#ASP] +synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic [] +synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] +synonym: "aminosuccinic acid" EXACT RESID-alternate [] +synonym: "D-aspartic acid" EXACT RESID-name [] +xref: DiffAvg: "0.00" +xref: DiffFormula: "C 0 H 0 N 0 O 0" +xref: DiffMono: "0.000000" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "D" +xref: Source: "artifactual" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01942 ! D-aspartic acid + +[Term] +id: MOD:01922 +name: 3-methoxydehydroalanine +def: "A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine." [PubMed:19745839, RESID:AA0582] +synonym: "2-amino-3-methoxyprop-2-enoic acid" EXACT RESID-systematic [] +synonym: "3-methoxydehydroalanine" EXACT RESID-name [] +synonym: "3-methoxydidehydroalanine" EXACT RESID-alternate [] +xref: DiffAvg: "12.01" +xref: DiffFormula: "C 1 H 0 N 0 O 0" +xref: DiffMono: "12.000000" +xref: Formula: "C 4 H 5 N 1 O 2" +xref: MassAvg: "99.09" +xref: MassMono: "99.032028" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +relationship: has_functional_parent MOD:00189 ! dehydroalanine (Ser) + +[Term] +id: MOD:01923 +name: N6-(L-aspartyl)-L-lysine +def: "A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water." [PubMed:15044436, RESID:AA0583] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "alpha-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] +synonym: "aspartyl N6-lysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-(alpha-aspartyl)lysine" EXACT RESID-alternate [] +synonym: "N6-(L-aspartyl)-L-lysine" EXACT RESID-name [] +synonym: "XLNK-4Asp-N6Lys(Asp)" EXACT PSI-MOD-label [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 10 H 16 N 3 O 4" +xref: MassAvg: "242.26" +xref: MassMono: "242.114081" +xref: Origin: "D, K" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01924 +name: S-octanoyl-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine." [PubMed:12591875, PubMed:16342964, RESID:AA0584] +synonym: "(2S)-2-amino-3-(octanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-3-(octanoylthio)propanoic acid" EXACT RESID-alternate [] +synonym: "ACT_SITE Acyl-thioester intermediate" EXACT UniProt-feature [] +synonym: "cysteine octanoate thioester" EXACT RESID-alternate [] +synonym: "S-octanoyl-L-cysteine" EXACT RESID-name [] +xref: DiffAvg: "126.20" +xref: DiffFormula: "C 8 H 14 N 0 O 1 S 0" +xref: DiffMono: "126.104465" +xref: Formula: "C 11 H 19 N 1 O 2 S 1" +xref: MassAvg: "229.34" +xref: MassMono: "229.113650" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00666 ! octanoylated residue +is_a: MOD:00672 ! S-acylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01925 +name: (2S,5R)-5-hydroxylysine +def: "A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine." [ChEBI:18040, PubMed:13375629, PubMed:15504407, PubMed:16101297, PubMed:2857489, RESID:AA0028] +subset: PSI-MOD-slim +synonym: "(2S,5R)-2,6-diamino-5-hydroxyhexanoic acid" EXACT RESID-systematic [] +synonym: "(2S,5R)-5-hydroxylysine" EXACT RESID-name [] +synonym: "2,6-bisazanyl-5-hydroxyhexanoic acid" EXACT RESID-alternate [] +synonym: "2,6-diamino-2,3,4,6-tetradeoxyhexonic acid" EXACT RESID-alternate [] +synonym: "5-hydroxylated L-lysine" EXACT PSI-MOD-alternate [] +synonym: "5HyLys" EXACT PSI-MOD-label [] +synonym: "alpha,epsilon-diamino-delta-hydroxycaproic acid" EXACT RESID-alternate [] +synonym: "L-erythro-delta-hydroxylysine" EXACT RESID-alternate [] +synonym: "MOD_RES (2S,5R)-5-hydroxylysine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 2 O 2" +xref: MassAvg: "144.17" +xref: MassMono: "144.089878" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00037 ! 5-hydroxy-L-lysine + +[Term] +id: MOD:01926 +name: 3-hydroxy-L-aspartic acid +def: "A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues." [OMSSA:59, UniMod:35#D] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-hydroxybutanedioic acid" EXACT PSI-MOD-alternate [] +synonym: "(2S)-3-hydroxyaspartic acid" EXACT PSI-MOD-alternate [] +synonym: "3HyAsp" EXACT PSI-MOD-label [] +synonym: "erythro-beta-hydroxylated L-aspartic acid" EXACT PSI-MOD-alternate [] +synonym: "hydroxylationd" EXACT OMSSA-label [] +synonym: "monohydroxylated aspartic acid" EXACT PSI-MOD-alternate [] +synonym: "Oxidation" RELATED PSI-MS-label [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 4 H 5 N 1 O 4" +xref: MassAvg: "131.09" +xref: MassMono: "131.021858" +xref: Origin: "D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00425 ! monohydroxylated residue +is_a: MOD:00904 ! modified L-aspartic acid residue + +[Term] +id: MOD:01927 +name: O-glycosyl-L-tyrosine +def: "A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine." [PubMed:18688235] +subset: PSI-MOD-slim +synonym: "OGlycoTyr" EXACT PSI-MOD-label [] +xref: Origin: "Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00396 ! O-glycosylated residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01928 +name: N-(L-isoaspartyl)-glycine +def: "A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine." [ChEBI:21479, PubMed:1826288, RESID:AA0126] +comment: Cross-link 2. +synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate [] +synonym: "isoaspartyl glycine" EXACT RESID-alternate [] +synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name [] +synonym: "N-beta-aspartylglycine" EXACT RESID-alternate [] +synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate [] +synonym: "XLNK-4Asp-NGly" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 7 N 2 O 3" +xref: MassAvg: "155.13" +xref: MassMono: "155.045667" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:00908 ! modified glycine residue + +[Term] +id: MOD:01929 +name: N6-(L-isoaspartyl)-L-lysine +def: "A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine." [ChEBI:21862, DeltaMass:0, PubMed:11000116, PubMed:6503713, RESID:AA0294] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] +synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature [] +synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate [] +synonym: "N-(beta-Aspartyl)-Lysine (Crosslink)" EXACT DeltaMass-label [] +synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name [] +synonym: "XLNK-4Asp-N6Lys" EXACT PSI-MOD-label [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 10 H 15 N 3 O 3" +xref: MassAvg: "225.25" +xref: MassMono: "225.111341" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00688 ! isopeptide crosslinked residues +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01930 +name: D-aspartic acid (Asn) +def: "A protein modification that effectively converts an L-asparagine residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190#ASN] +synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic [] +synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] +synonym: "aminosuccinic acid" EXACT RESID-alternate [] +synonym: "D-aspartic acid" EXACT RESID-name [] +xref: DiffAvg: "0.98" +xref: DiffFormula: "C 0 H -1 N -1 O 1" +xref: DiffMono: "0.984016" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "N" +xref: Source: "artifactual" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01942 ! D-aspartic acid + +[Term] +id: MOD:01931 +name: N6-phospho-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine." [PubMed:20144148, RESID:AA0585] +synonym: "(2S)-2-amino-6-(phosphonoamino)hexanoic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-azanyl-6-(phosphonoamino)hexanoic acid" EXACT RESID-alternate [] +synonym: "6-phospholysine" EXACT RESID-alternate [] +synonym: "N(6)-phosphonolysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-phospholysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-phosphonolysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-phosphonyllysine" EXACT RESID-alternate [] +synonym: "N(epsilon)-phosphoryllysine" EXACT RESID-alternate [] +synonym: "N6-phospho-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "79.98" +xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" +xref: DiffMono: "79.966331" +xref: Formula: "C 6 H 13 N 2 O 4 P 1" +xref: MassAvg: "208.15" +xref: MassMono: "208.061294" +xref: Origin: "K" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01456 ! N-phosphorylated residue + +[Term] +id: MOD:01932 +name: L-lysinonorleucine +def: "A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.." [PubMed:5117030, PubMed:5817620, PubMed:5879466, PubMed:6030254, RESID:AA0586] +comment: Cross-link 2. +synonym: "(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "(2S,2'S)-6,6'-iminobis(2-aminohexanoic acid)" EXACT RESID-alternate [] +synonym: "6-(N6-L-lysino)-L-norleucine" EXACT RESID-alternate [] +synonym: "L-lysinonorleucine" EXACT RESID-name [] +synonym: "lysinonorleucine" EXACT RESID-alternate [] +synonym: "lysinorleucine [misspelling]" EXACT RESID-alternate [] +synonym: "lysylnorleucine" EXACT RESID-alternate [] +synonym: "N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 12 H 21 N 3 O 2" +xref: MassAvg: "239.32" +xref: MassMono: "239.163377" +xref: Origin: "K, K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia + +[Term] +id: MOD:01933 +name: desmosine +def: "A protein modification that effectively cross-links four L-lysine residues to form desmosine." [ChEBI:37629, PubMed:13941623, PubMed:14109938, PubMed:14109939, PubMed:5839176, RESID:AA0587] +comment: Cross-link 4. +synonym: "4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium" EXACT RESID-systematic [] +synonym: "6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine" EXACT RESID-alternate [] +synonym: "desmosine" EXACT RESID-name [] +xref: DiffAvg: "-58.15" +xref: DiffFormula: "C 0 H -16 N -3 O 0" +xref: DiffMono: "-58.134971" +xref: FormalCharge: "1+" +xref: Formula: "C 24 H 32 N 5 O 4" +xref: MassAvg: "454.55" +xref: MassMono: "454.244881" +xref: Origin: "K, K, K, K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01425 ! pyridinyl ring crosslinked residues + +[Term] +id: MOD:01934 +name: isodesmosine +def: "A protein modification that effectively cross-links four L-lysine residues to form isodesmosine." [ChEBI:37629, PubMed:13941623, PubMed:14109938, PubMed:14109939, PubMed:5839176, RESID:AA0588] +comment: Cross-link 4. +synonym: "2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium" EXACT RESID-systematic [] +synonym: "6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine" EXACT RESID-alternate [] +synonym: "isodesmosine" EXACT RESID-name [] +xref: DiffAvg: "-58.15" +xref: DiffFormula: "C 0 H -16 N -3 O 0" +xref: DiffMono: "-58.134971" +xref: FormalCharge: "1+" +xref: Formula: "C 24 H 32 N 5 O 4" +xref: MassAvg: "454.55" +xref: MassMono: "454.244881" +xref: Origin: "K, K, K, K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue +is_a: MOD:01425 ! pyridinyl ring crosslinked residues + +[Term] +id: MOD:01935 +name: O-glucosyl-L-hydroxylysine +def: "modification from RESID" [PubMed:22045808, RESID:AA0589] +synonym: "(D-glucopyranosyl)oxy-L-lysine" EXACT RESID-systematic [] +synonym: "O-glucosyl-L-hydroxylysine" EXACT RESID-name [] +xref: DiffAvg: "178.14" +xref: DiffFormula: "C 6 H 10 N 0 O 6" +xref: DiffMono: "178.047738" +xref: Formula: "C 12 H 22 N 2 O 7" +xref: MassAvg: "306.32" +xref: MassMono: "306.142701" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01047 ! monohydroxylated lysine + +[Term] +id: MOD:01936 +name: N6-oleoyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine." [PubMed:20942504, RESID:AA0590] +synonym: "(2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid" EXACT RESID-systematic [] +synonym: "N6-[(9Z)-1-oxo-9-octadecenyl]lysine" EXACT RESID-alternate [] +synonym: "N6-oleoyl-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "264.45" +xref: DiffFormula: "C 18 H 32 N 0 O 1" +xref: DiffMono: "264.245316" +xref: Formula: "C 24 H 44 N 2 O 2" +xref: MassAvg: "392.63" +xref: MassMono: "392.340279" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01937 +name: N-palmitoyl-L-methionine +def: "A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine." [PubMed:20942504, RESID:AA0591] +synonym: "(2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] +synonym: "LIPID N-palmitoyl methionine" EXACT UniProt-feature [] +synonym: "N-(1-oxohexadecyl)methionine" EXACT RESID-alternate [] +synonym: "N-palmitoyl-L-methionine" EXACT RESID-name [] +xref: DiffAvg: "238.41" +xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" +xref: DiffMono: "238.229666" +xref: Formula: "C 21 H 40 N 1 O 2 S 1" +xref: MassAvg: "370.62" +xref: MassMono: "370.277976" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00913 ! modified L-methionine residue +is_a: MOD:01685 ! alpha-amino palmitoylated residue + +[Term] +id: MOD:01938 +name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asn) +def: "A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia." [RESID:AA0592#ASN] +comment: Cross-link 2. +synonym: "(2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid" EXACT RESID-name [] +synonym: "aspartimide cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 7 H 8 N 2 O 3 S 1" +xref: MassAvg: "200.21" +xref: MassMono: "200.025563" +xref: Origin: "C, N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01945 ! 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid + +[Term] +id: MOD:01939 +name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asp) +def: "A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule." [RESID:AA0592#ASP] +comment: Cross-link 2. +synonym: "(2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid" EXACT RESID-systematic [] +synonym: "2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid" EXACT RESID-name [] +synonym: "aspartimide cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 8 N 2 O 3 S 1" +xref: MassAvg: "200.21" +xref: MassMono: "200.025563" +xref: Origin: "C, D" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01945 ! 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid + +[Term] +id: MOD:01940 +name: 2-(2-aminosuccinimidyl)pentanedioic acid (Asn) +def: "A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia." [RESID:AA0593#ASN] +comment: Cross-link 2. +synonym: "(4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "2-(2-aminosuccinimidyl)pentanedioic acid" EXACT RESID-name [] +synonym: "aspartimide glutamic acid" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 9 H 10 N 2 O 5" +xref: MassAvg: "226.19" +xref: MassMono: "226.058971" +xref: Origin: "E, N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01946 ! 2-(2-aminosuccinimidyl)pentanedioic acid + +[Term] +id: MOD:01941 +name: 2-(2-aminosuccinimidyl)pentanedioic acid (Asp) +def: "A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule." [RESID:AA0593#ASP] +comment: Cross-link 2. +synonym: "(4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "2-(2-aminosuccinimidyl)pentanedioic acid" EXACT RESID-name [] +synonym: "aspartimide glutamic acid" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 9 H 10 N 2 O 5" +xref: MassAvg: "226.19" +xref: MassMono: "226.058971" +xref: Origin: "D, E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:01946 ! 2-(2-aminosuccinimidyl)pentanedioic acid + +[Term] +id: MOD:01942 +name: D-aspartic acid +def: "A protein modification that effectively converts a source amino acid residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190] +synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic [] +synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] +synonym: "aminosuccinic acid" EXACT RESID-alternate [] +synonym: "D-aspartic acid" EXACT RESID-name [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 4 H 5 N 1 O 3" +xref: MassAvg: "115.09" +xref: MassMono: "115.026943" +xref: Origin: "X" +xref: Source: "artifactual" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01943 +name: pyrrolidione ring crosslinked residues +def: "A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring." [PubMed:18688235] +is_a: MOD:00033 ! crosslinked residues + +[Term] +id: MOD:01944 +name: 2-aminosuccinimide ring crosslinked residues +def: "A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue." [PubMed:18688235] +comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. +subset: PSI-MOD-slim +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00859 ! modified residue that can arise from different natural residues + +[Term] +id: MOD:01945 +name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid +def: "A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue." [PubMed:18688235] +comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 6 N 2 O 3" +xref: MassAvg: "154.13" +xref: MassMono: "154.037842" +xref: Origin: "C, X" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues + +[Term] +id: MOD:01946 +name: 2-(2-aminosuccinimidyl)pentanedioic acid +def: "A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid\n residue." [PubMed:18688235] +comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 6 H 6 N 2 O 3" +xref: MassAvg: "154.13" +xref: MassMono: "154.037842" +xref: Origin: "E, X" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues + +[Term] +id: MOD:01947 +name: O-(L-isoaspartyl)-L-threonine (cross-link) +def: "A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form O-(L-isoaspartyl)-L-threonine." [PubMed:17157318, PubMed:8706862, RESID:AA0525#TDX] +comment: Cross-link 2. +synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate [] +synonym: "CROSSLNK isoaspartyl threonine ester (Thr-Asp)" EXACT UniProt-feature [] +synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1" +xref: DiffMono: "-18.010565" +xref: Formula: "C 8 H 10 N 2 O 4" +xref: MassAvg: "198.18" +xref: MassMono: "198.064057" +xref: Origin: "D, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00885 ! ester crosslinked residues +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01978 ! O-(L-isoaspartyl)-L-threonine + +[Term] +id: MOD:01948 +name: labionin +def: "A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin." [PubMed:20082397, RESID:AA0594] +comment: Cross-link 3. +synonym: "(2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid" EXACT RESID-systematic [] +synonym: "(2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid" EXACT RESID-alternate [] +synonym: "(2S,4S,8R)-labionin" EXACT RESID-alternate [] +synonym: "labionin" EXACT RESID-name [] +xref: DiffAvg: "-36.03" +xref: DiffFormula: "C 0 H -4 N 0 O -2 S 0" +xref: DiffMono: "-36.021129" +xref: Formula: "C 9 H 11 N 3 O 3 S 1" +xref: MassAvg: "241.26" +xref: MassMono: "241.052112" +xref: Origin: "C, S, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01993 ! beta-carbon thioether crosslinked residues + +[Term] +id: MOD:01949 +name: coelenterazine +def: "A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine." [ChEBI:2311, PubMed:10830969, PubMed:11572972, PubMed:19833098, RESID:AA0595] +comment: Cross-link 3. +synonym: "8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one" EXACT RESID-systematic [] +synonym: "coelenterazine" EXACT RESID-name [] +synonym: "Oplophorus luciferin" EXACT RESID-alternate [] +xref: DiffAvg: "-50.06" +xref: DiffFormula: "C -1 H -6 N 0 O -2" +xref: DiffMono: "-50.036779" +xref: Formula: "C 26 H 21 N 3 O 3" +xref: MassAvg: "423.47" +xref: MassMono: "423.158292" +xref: Origin: "F, Y, Y" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:00033 ! crosslinked residues +is_a: MOD:00914 ! modified L-phenylalanine residue +is_a: MOD:00919 ! modified L-tyrosine residue + +[Term] +id: MOD:01950 +name: L-isoglutamyl histamine +def: "A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine." [PubMed:23022564, RESID:AA0596] +synonym: "(2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(gamma-glutamyl)histamine" EXACT RESID-alternate [] +synonym: "L-isoglutamyl histamine" EXACT RESID-name [] +xref: DiffAvg: "94.12" +xref: DiffFormula: "C 5 H 6 N 2 O 0" +xref: DiffMono: "94.053098" +xref: Formula: "C 10 H 14 N 4 O 2" +xref: MassAvg: "222.25" +xref: MassMono: "222.111676" +xref: Origin: "Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:01951 +name: O-(L-isoglutamyl)-L-serine (Gln-Ser) +def: "A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine." [PubMed:17051152, RESID:AA0597#QSX] +comment: Cross-link 2. +synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name [] +synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 8 H 10 N 2 O 4" +xref: MassAvg: "198.18" +xref: MassMono: "198.064057" +xref: Origin: "Q, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:00946 ! crosslinked residues with loss of ammonia +is_a: MOD:01977 ! O-(L-isoglutamyl)-L-serine + +[Term] +id: MOD:01952 +name: O-(L-isoglutamyl)-L-threonine (cross-link) +def: "A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine." [PubMed:17051152, RESID:AA0536#TQX] +comment: Cross-link 2. +synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] +synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] +synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] +xref: DiffAvg: "-17.03" +xref: DiffFormula: "C 0 H -3 N -1 O 0" +xref: DiffMono: "-17.026549" +xref: Formula: "C 9 H 12 N 2 O 4" +xref: MassAvg: "212.20" +xref: MassMono: "212.079707" +xref: Origin: "Q, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00885 ! ester crosslinked residues +is_a: MOD:00907 ! modified L-glutamine residue +is_a: MOD:01979 ! O-(L-isoglutamyl)-L-threonine + +[Term] +id: MOD:01953 +name: tetrakis-L-cysteinyl tetrairon octanitrosyl +def: "A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl." [PubMed:21182249, RESID:AA0599] +comment: Cross-link 4. +xref: DiffAvg: "459.40" +xref: DiffFormula: "C 0 Fe 4 H -4 N 8 O 8 S 0" +xref: DiffMono: "459.692359" +xref: Formula: "C 12 Fe 4 H 16 N 12 O 12 S 4" +xref: MassAvg: "871.95" +xref: MassMono: "871.729098" +xref: Origin: "C, C, C, C" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00738 ! iron containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01954 +name: dehydroalanine (Sec) +def: "A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine." [ChEBI:17123, PubMed:10220322, PubMed:12781460, PubMed:1547888, PubMed:1815586, PubMed:20805503, PubMed:21420488, PubMed:22031445, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181] +synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] +synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] +synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] +synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] +synonym: "anhydroserine" EXACT RESID-alternate [] +synonym: "dehydroalanine" EXACT RESID-name [] +synonym: "Dha" EXACT RESID-alternate [] +xref: DiffAvg: "-80.99" +xref: DiffFormula: "C 0 H -2 N 0 O 0 Se -1" +xref: DiffMono: "-81.932171" +xref: Formula: "C 3 H 3 N 1 O 1" +xref: MassAvg: "69.06" +xref: MassMono: "69.021464" +xref: Origin: "U" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01158 ! modified L-selenocysteine residue +is_a: MOD:01168 ! dehydroalanine + +[Term] +id: MOD:01955 +name: L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide +def: "modification from RESID" [PubMed:21499260, RESID:AA0600] +comment: Cross-link 7. +synonym: "4Mn-Ca-5O cluster" EXACT RESID-alternate [] +synonym: "L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide" EXACT RESID-name [] +synonym: "mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese" EXACT RESID-systematic [] +synonym: "photosystem II catalytic cluster" EXACT RESID-alternate [] +xref: DiffAvg: "333.78" +xref: DiffFormula: "C 0 Ca 1 H -6 Mn 4 N 0 O 5" +xref: DiffMono: "333.642394" +xref: Formula: "C 32 Ca 1 H 38 Mn 4 N 9 O 23" +xref: MassAvg: "1176.53" +xref: MassMono: "1175.922825" +xref: Origin: "A, D, D, E, E, E, H" +xref: Source: "natural" +xref: TermSpec: "C-term" +is_a: MOD:00740 ! manganese containing modified residue +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:00904 ! modified L-aspartic acid residue +is_a: MOD:00906 ! modified L-glutamic acid residue +is_a: MOD:00909 ! modified L-histidine residue +is_a: MOD:01482 ! calcium containing modified residue + +[Term] +id: MOD:01956 +name: (3R)-3-hydroxy-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine." [PubMed:10094780, PubMed:23103944, PubMed:786730, RESID:AA0601] +synonym: "(2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid" EXACT RESID-systematic [] +synonym: "(3R)-3-hydroxy-L-arginine" EXACT RESID-name [] +synonym: "2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] +synonym: "2-amino-5-guanidino-3-hydroxypentanoic acid" EXACT RESID-alternate [] +synonym: "beta-hydroxyarginine" EXACT RESID-alternate [] +synonym: "C(beta)-hydroxyarginine" EXACT RESID-alternate [] +synonym: "MOD_RES (3R)-3-hydroxyarginine" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 6 H 12 N 4 O 2" +xref: MassAvg: "172.19" +xref: MassMono: "172.096026" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00682 ! hydroxylated arginine + +[Term] +id: MOD:01957 +name: 2-hydroxyproline +def: "A protein modification that effectively converts an L-proline residue to 2-hydroxyproline." [PubMed:23385463, RESID:AA0602] +synonym: "(2R)-2-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] +synonym: "2-hydroxyproline" EXACT RESID-name [] +synonym: "2-oxidanylpyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] +synonym: "alpha-hydroxyproline" EXACT RESID-alternate [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 7 N 1 O 2" +xref: MassAvg: "113.12" +xref: MassMono: "113.047678" +xref: Origin: "P" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01024 ! monohydroxylated proline + +[Term] +id: MOD:01958 +name: bis-L-cysteinyl bisglutathion-S-yl diiron disulfide +def: "A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide." [PubMed:17121859, RESID:AA0603] +comment: Cross-link 2. +synonym: "bis-L-cysteinyl bisglutathion-S-yl diiron disulfide" EXACT RESID-name [] +synonym: "di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron" EXACT RESID-systematic [] +synonym: "mitochondrial glutaredoxin 2 dimer iron-sulfur cluster" EXACT RESID-alternate [] +synonym: "plant glutaredoxin C1 dimer iron-sulfur cluster" EXACT RESID-alternate [] +xref: DiffAvg: "786.42" +xref: DiffFormula: "C 20 Fe 2 H 30 N 6 O 12 S 4" +xref: DiffMono: "785.950329" +xref: Formula: "C 26 Fe 2 H 40 N 8 O 14 S 6" +xref: MassAvg: "992.70" +xref: MassMono: "991.968699" +xref: Origin: "C, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01959 +name: tris-L-cysteinyl L-glutamato tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide." [PubMed:21167158, RESID:AA0604] +comment: Cross-link 4. +synonym: "tris-L-cysteinyl L-glutamato tetrairon tetrasulfide" EXACT RESID-name [] +synonym: "tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon" EXACT RESID-systematic [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.596734" +xref: Formula: "C 14 Fe 4 H 18 N 4 O 6 S 7" +xref: MassAvg: "786.12" +xref: MassMono: "785.666881" +xref: Origin: "C, C, C, E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01960 +name: tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide +def: "A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide." [PubMed:11796730, RESID:AA0605] +comment: Cross-link 4. +synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] +synonym: "tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide" EXACT RESID-name [] +synonym: "tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon" EXACT RESID-systematic [] +xref: DiffAvg: "347.59" +xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" +xref: DiffMono: "347.596734" +xref: Formula: "C 14 Fe 4 H 19 N 5 O 5 S 7" +xref: MassAvg: "785.14" +xref: MassMono: "784.682866" +xref: Origin: "C, C, C, Q" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00739 ! iron-sulfur cluster containing modification +is_a: MOD:00905 ! modified L-cysteine residue +is_a: MOD:00907 ! modified L-glutamine residue + +[Term] +id: MOD:01961 +name: O-(L-isoglutamyl)-L-threonine (THR) +def: "OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785." [PubMed:16618936, PubMed:17051152, PubMed:17687277, PubMed:18555071, RESID:AA0536#THR] +synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] +synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] +synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] +xref: DiffAvg: "129.12" +xref: DiffFormula: "C 5 H 7 N 1 O 3" +xref: DiffMono: "129.042593" +xref: Formula: "C 9 H 14 N 2 O 5" +xref: MassAvg: "230.22" +xref: MassMono: "230.090272" +xref: Origin: "T" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01962 +name: N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine +def: "A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine." [PubMed:12186869, PubMed:19236052, RESID:AA0606] +synonym: "(2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "DABA" EXACT RESID-alternate [] +synonym: "DATDH" EXACT RESID-alternate [] +synonym: "DiNAcBac" EXACT RESID-alternate [] +synonym: "N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine" EXACT RESID-name [] +synonym: "N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine" EXACT RESID-alternate [] +synonym: "N4-[N,N-diacetylbacillosaminyl]asparagine" EXACT RESID-alternate [] +synonym: "N4-[N2,N4-diacetylbacillosaminyl]asparagine" EXACT RESID-alternate [] +xref: DiffAvg: "228.25" +xref: DiffFormula: "C 10 H 16 N 2 O 4" +xref: DiffMono: "228.111007" +xref: Formula: "C 14 H 22 N 4 O 6" +xref: MassAvg: "342.35" +xref: MassMono: "342.153934" +xref: Origin: "N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00160 ! N4-glycosyl-L-asparagine + +[Term] +id: MOD:01963 +name: O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine." [PubMed:23030644, RESID:AA0607] +synonym: "(2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic [] +synonym: "DABA" EXACT RESID-alternate [] +synonym: "DATDH" EXACT RESID-alternate [] +synonym: "DiNAcBac" EXACT RESID-alternate [] +synonym: "O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine" EXACT RESID-name [] +synonym: "O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine" EXACT RESID-alternate [] +synonym: "O-[N,N-diacetylbacillosaminyl]serine" EXACT RESID-alternate [] +synonym: "O-[N2,N4-diacetylbacillosaminyl]serine" EXACT RESID-alternate [] +xref: DiffAvg: "228.25" +xref: DiffFormula: "C 10 H 16 N 2 O 4" +xref: DiffMono: "228.111007" +xref: Formula: "C 13 H 21 N 3 O 6" +xref: MassAvg: "315.33" +xref: MassMono: "315.143035" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:01964 +name: O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine." [PubMed:17804791, RESID:AA0608] +synonym: "(2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic [] +synonym: "GATDH" EXACT RESID-alternate [] +synonym: "O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] +synonym: "O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine" EXACT RESID-name [] +synonym: "O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine" EXACT RESID-alternate [] +xref: DiffAvg: "274.27" +xref: DiffFormula: "C 11 H 18 N 2 O 6" +xref: DiffMono: "274.116486" +xref: Formula: "C 14 H 23 N 3 O 8" +xref: MassAvg: "361.35" +xref: MassMono: "361.148515" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00002 ! O-glycosyl-L-serine + +[Term] +id: MOD:01965 +name: 2xC(13),3x(2)H labeled N6-acetyl-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine." [PubMed:18688235] +synonym: "Acetate labeling reagent (K) (heavy form, +5amu)" EXACT PSI-MOD-alternate [] +synonym: "COFRADIC heavy acetyl 13C2 2H3" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "47.04" +xref: DiffFormula: "(13)C 2 (1)H -1 (2)H 3 O 1" +xref: DiffMono: "47.036105" +xref: Formula: "(12)C 6 (13)C 2 (1)H 11 (2)H 3 N 2 O 2" +xref: MassAvg: "175.13" +xref: MassMono: "175.131068" +xref: Origin: "K" +xref: Source: "artifact" +xref: TermSpec: "none" +is_a: MOD:00064 ! N6-acetyl-L-lysine +is_a: MOD:01428 ! (13)C isotope tagged reagent +is_a: MOD:01431 ! (2)H deuterium tagged reagent + +[Term] +id: MOD:01966 +name: L-methionine (R)-sulfoxide +def: "OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720." [ChEBI:45764, PubMed:21406390, PubMed:22116028, PubMed:23911929, RESID:AA0581] +synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic [] +synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate [] +synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name [] +synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature [] +xref: DiffAvg: "16.00" +xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" +xref: DiffMono: "15.994915" +xref: Formula: "C 5 H 9 N 1 O 2 S 1" +xref: MassAvg: "147.19" +xref: MassMono: "147.035400" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_obsolete: true + +[Term] +id: MOD:01967 +name: omega-N-(N-acetylamino)glucosyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to omega-N-(N-acetylamino)glucosyl-L-arginine." [PubMed:23955153, RESID:AA0609] +synonym: "(2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid" EXACT RESID-systematic [] +synonym: "N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "N(omega)-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate [] +synonym: "NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "NG-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate [] +synonym: "omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "omega-N-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate [] +synonym: "omega-N-(N-acetylamino)glucosyl-L-arginine" EXACT RESID-name [] +xref: DiffAvg: "203.19" +xref: DiffFormula: "C 8 H 13 N 1 O 5" +xref: DiffMono: "203.079373" +xref: Formula: "C 14 H 25 N 5 O 6" +xref: MassAvg: "359.38" +xref: MassMono: "359.180484" +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00448 ! N-acetylaminoglucosylated residue +is_a: MOD:01980 ! omega-N-glycosyl-L-arginine + +[Term] +id: MOD:01968 +name: (2R,3R,2'R)-3-methyllanthionine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine." [PubMed:23314913, RESID:AA0610] +comment: Cross-link 2. +synonym: "(2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT RESID-systematic [] +synonym: "(2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate [] +synonym: "(2R,3R,2'R)-3-methyllanthionine" EXACT RESID-name [] +synonym: "(2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT RESID-alternate [] +synonym: "(2R,3R,6R)-3-methyllanthionine" EXACT RESID-alternate [] +synonym: "2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid" EXACT RESID-alternate [] +synonym: "3-methyl-L,L-lanthionine" EXACT RESID-alternate [] +synonym: "cysteine-3-L-butyrine thioether" EXACT RESID-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 10 N 2 O 2 S 1" +xref: MassAvg: "186.23" +xref: MassMono: "186.046299" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:01981 ! 3-methyllanthionine + +[Term] +id: MOD:01969 +name: S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine." [PubMed:9398217, RESID:AA0611] +synonym: "(2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate" EXACT UniProt-feature [] +synonym: "S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine" EXACT RESID-name [] +synonym: "S-(glutathion-1-yl)-L-cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "289.31" +xref: DiffFormula: "C 10 H 15 N 3 O 5 S 1" +xref: DiffMono: "289.073242" +xref: Formula: "C 13 H 20 N 4 O 6 S 2" +xref: MassAvg: "392.44" +xref: MassMono: "392.082426" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01970 +name: 5-glutamyl glutamic acid +def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid." [PubMed:10747868, PubMed:15525938, PubMed:1680872, PubMed:23434852, RESID:AA0612, UniMod:450] +synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid" EXACT RESID-systematic [] +synonym: "(2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid" EXACT RESID-alternate [] +synonym: "2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid" EXACT RESID-alternate [] +synonym: "5-glutamyl glutamic acid" EXACT RESID-name [] +synonym: "gamma-glutamylglutamate" EXACT RESID-alternate [] +synonym: "Glu" RELATED UniMod-interim [] +synonym: "isoglutamyl glutamic acid" EXACT RESID-alternate [] +synonym: "isoglutamyl monoglutamic acid" EXACT RESID-alternate [] +synonym: "MOD_RES 5-glutamyl glutamate" EXACT UniProt-feature [] +synonym: "monoglutamyl" RELATED UniMod-description [] +synonym: "N alpha -(gamma-Glutamyl)-Glu" EXACT DeltaMass-label [] +synonym: "N-(gamma-L-glutamyl)-L-glutamic acid" EXACT RESID-alternate [] +xref: DiffAvg: "129.12" +xref: DiffFormula: "C 5 H 7 N 1 O 3" +xref: DiffMono: "129.042593" +xref: Formula: "C 10 H 14 N 2 O 6" +xref: MassAvg: "258.23" +xref: MassMono: "258.085186" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid + +[Term] +id: MOD:01971 +name: 5-glutamyl N2-ornithine +def: "A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine." [PubMed:23434852, RESID:AA0613] +synonym: "(2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid" EXACT RESID-systematic [] +synonym: "4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid" EXACT RESID-alternate [] +synonym: "4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "5-glutamyl N2-ornithine" EXACT RESID-name [] +synonym: "gamma-glutamylornithine" EXACT RESID-alternate [] +synonym: "MOD_RES 5-glutamyl N2-ornithine" EXACT UniProt-feature [] +synonym: "N2-(gamma-glutamyl)ornithine" EXACT RESID-alternate [] +synonym: "N2-(L-isoglutamyl)-L-ornithine" EXACT RESID-alternate [] +xref: DiffAvg: "114.15" +xref: DiffFormula: "C 5 H 10 N 2 O 1" +xref: DiffMono: "114.079313" +xref: Formula: "C 10 H 17 N 3 O 4" +xref: MassAvg: "243.26" +xref: MassMono: "243.121906" +xref: Origin: "E" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00674 ! amidated residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01972 +name: 5-glutamyl coenzyme A thioester +def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester." [PubMed:16253988, PubMed:20977214, PubMed:7915164, RESID:AA0614] +synonym: "(2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester" EXACT RESID-alternate [] +synonym: "5-glutamyl coenzyme A thioester" EXACT RESID-name [] +synonym: "5-glutamyl coenzyme A thioester intermediate" EXACT UniProt-feature [] +xref: DiffAvg: "749.52" +xref: DiffFormula: "C 21 H 34 N 7 O 15 P 3 S 1" +xref: DiffMono: "749.104644" +xref: Formula: "C 26 H 41 N 8 O 18 P 3 S 1" +xref: MassAvg: "878.63" +xref: MassMono: "878.147237" +xref: Origin: "E" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00860 ! sulfur containing modified residue +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:00906 ! modified L-glutamic acid residue + +[Term] +id: MOD:01973 +name: N6-(3-phosphoglyceryl)-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine." [PubMed:23908237, RESID:AA0615] +synonym: "(2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid" EXACT RESID-systematic [] +synonym: "3-phosphoglyceryl-lysine" EXACT RESID-alternate [] +synonym: "N6-(3-phosphoglyceryl)-L-lysine" EXACT RESID-name [] +xref: DiffAvg: "168.04" +xref: DiffFormula: "C 3 H 5 N 0 O 6 P 1" +xref: DiffMono: "167.982375" +xref: Formula: "C 9 H 17 N 2 O 7 P 1" +xref: MassAvg: "296.22" +xref: MassMono: "296.077338" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00861 ! phosphorus containing modified residue +is_a: MOD:01875 ! N6-acylated L-lysine + +[Term] +id: MOD:01974 +name: S-methyl-L-methionine +def: "A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine." [ChEBI:17728, PubMed:23532849, RESID:AA0616] +synonym: "(2S)-2-amino-4-(dimethylsulfonio)butanoate" EXACT RESID-alternate [] +synonym: "(3S)-(3-amino-3-carboxypropyl)dimethylsulfanium" EXACT RESID-systematic [] +synonym: "[(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium" EXACT RESID-alternate [] +synonym: "S-methyl-L-methionine" EXACT RESID-name [] +synonym: "S-methylmethionine" EXACT RESID-alternate [] +synonym: "S-methylmethioninium" EXACT RESID-alternate [] +synonym: "vitamin U" EXACT RESID-alternate [] +xref: DiffAvg: "15.03" +xref: DiffFormula: "C 1 H 3 N 0 O 0 S 0" +xref: DiffMono: "15.022927" +xref: FormalCharge: "1+" +xref: Formula: "C 6 H 12 N 1 O 1 S 1" +xref: MassAvg: "146.23" +xref: MassMono: "146.063411" +xref: Origin: "M" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00716 ! methylated methionine + +[Term] +id: MOD:01975 +name: S-poly(3-hydroxybutyrate)-L-cysteine +def: "A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine." [PubMed:19711985, PubMed:9888824, RESID:AA0617] +synonym: "(alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)" EXACT RESID-systematic [] +synonym: "S-poly(3-hydroxybutanoate)cysteine" EXACT RESID-alternate [] +synonym: "S-poly(3-hydroxybutanoic acid)cysteine" EXACT RESID-alternate [] +synonym: "S-poly(3-hydroxybutyrate)-L-cysteine" EXACT RESID-name [] +synonym: "S-poly(3-hydroxybutyrate)cysteine" EXACT RESID-alternate [] +synonym: "S-poly(3-hydroxybutyric acid)cysteine" EXACT RESID-alternate [] +synonym: "S-poly(beta-hydroxybutyrate)cysteine" EXACT RESID-alternate [] +synonym: "S-poly[(R)-3-hydroxybutyrate]cysteine" EXACT RESID-alternate [] +xref: DiffAvg: "172.18" +xref: DiffFormula: "C 8 H 12 N 0 O 4 S 0" +xref: DiffMono: "172.073559" +xref: Formula: "C 11 H 17 N 1 O 5 S 1" +xref: MassAvg: "275.32" +xref: MassMono: "275.082744" +xref: Origin: "C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00672 ! S-acylated residue +is_a: MOD:00905 ! modified L-cysteine residue + +[Term] +id: MOD:01976 +name: O3-(poly-3-hydroxybutyrate)-L-serine +def: "A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine." [PubMed:17659252, PubMed:20004640, RESID:AA0618] +subset: PSI-MOD-slim +synonym: "(2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid" EXACT RESID-systematic [] +synonym: "O3-(poly-3-hydroxybutyrate)-L-serine" EXACT RESID-name [] +synonym: "O3-poly(3-hydroxybutanoate)serine" EXACT RESID-alternate [] +synonym: "O3-poly(3-hydroxybutanoic acid)serine" EXACT RESID-alternate [] +synonym: "O3-poly(3-hydroxybutyrate)serine" EXACT RESID-alternate [] +synonym: "O3-poly(3-hydroxybutyric acid)serine" EXACT RESID-alternate [] +synonym: "O3-poly(beta-hydroxybutyrate)serine" EXACT RESID-alternate [] +synonym: "O3-poly[(R)-3-hydroxybutyrate]serine" EXACT RESID-alternate [] +xref: DiffAvg: "172.18" +xref: DiffFormula: "C 8 H 12 N 0 O 4" +xref: DiffMono: "172.073559" +xref: Formula: "C 11 H 17 N 1 O 6" +xref: MassAvg: "259.26" +xref: MassMono: "259.105587" +xref: Origin: "S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00671 ! O-acylated residue +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01977 +name: O-(L-isoglutamyl)-L-serine +def: "A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond to form O-(L-isoglutamyl)-L-serine." [PubMed:17051152, RESID:AA0597] +comment: Cross-link 2. +synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name [] +synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 8 H 10 N 2 O 4" +xref: MassAvg: "198.18" +xref: MassMono: "198.064057" +xref: Origin: "S, X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00885 ! ester crosslinked residues +is_a: MOD:00916 ! modified L-serine residue + +[Term] +id: MOD:01978 +name: O-(L-isoaspartyl)-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water." [PubMed:8706862, RESID:AA0525] +comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. +synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate [] +synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 8 H 12 N 2 O 5" +xref: MassAvg: "216.19" +xref: MassMono: "216.074621" +xref: Origin: "T, X" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01979 +name: O-(L-isoglutamyl)-L-threonine +def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia." [PubMed:8706862, RESID:AA0536] +comment: This is not an ester cross-link of peptides [JSG]. +synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] +synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] +synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] +synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] +synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] +synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] +xref: DiffAvg: "none" +xref: DiffFormula: "none" +xref: DiffMono: "none" +xref: Formula: "C 9 H 14 N 2 O 5" +xref: MassAvg: "230.22" +xref: MassMono: "230.090272" +xref: Origin: "T, X" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:00859 ! modified residue that can arise from different natural residues +is_a: MOD:00917 ! modified L-threonine residue + +[Term] +id: MOD:01980 +name: omega-N-glycosyl-L-arginine +def: "A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine." [PubMed:15279557, PubMed:8521968, PubMed:9536051, RESID:AA0327, UniMod:41#R] +synonym: "(2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] +synonym: "Hex" RELATED PSI-MS-label [] +synonym: "Hexose" RELATED UniMod-description [] +synonym: "NG-beta-D-glucosylarginine" EXACT RESID-alternate [] +synonym: "omega-N-(beta-D-glucosyl)-L-arginine" EXACT RESID-alternate [] +synonym: "omega-N-glucosyl-L-arginine" EXACT RESID-name [] +synonym: "omega-N-glycosyl-L-arginine" EXACT RESID-alternate [] +xref: Origin: "R" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00006 ! N-glycosylated residue +is_a: MOD:00902 ! modified L-arginine residue + +[Term] +id: MOD:01981 +name: 3-methyllanthionine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity." [PubMed:18688235] +comment: Cross-link 2. +synonym: "2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT PSI-MOD-alternate [] +synonym: "2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT PSI-MOD-alternate [] +synonym: "2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid" EXACT PSI-MOD-alternate [] +synonym: "3-methyllanthionine" EXACT PSI-MOD-alternate [] +synonym: "cysteine-3-L-butyrine thioether" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "-18.02" +xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" +xref: DiffMono: "-18.010565" +xref: Formula: "C 7 H 10 N 2 O 2 S 1" +xref: MassAvg: "186.23" +xref: MassMono: "186.046299" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:00954 ! crosslinked residues with loss of water +is_a: MOD:01993 ! beta-carbon thioether crosslinked residues + +[Term] +id: MOD:01982 +name: N,N,N-trimethylglycine +def: "modification from RESID" [ChEBI:17750, PubMed:23818633, PubMed:23978223, RESID:AA0619] +subset: PSI-MOD-slim +synonym: "(trimethylammonio)ethanoic acid" EXACT RESID-alternate [] +synonym: "1-carboxy-N,N,N-trimethylmethanazanium" EXACT RESID-alternate [] +synonym: "2-trimethylammonioacetate" EXACT RESID-alternate [] +synonym: "betaine" EXACT RESID-alternate [] +synonym: "carboxy-N,N,N-trimethylmethanaminium" EXACT RESID-systematic [] +synonym: "carboxymethyl-trimethylazanium" EXACT RESID-alternate [] +synonym: "glycine betaine" EXACT RESID-alternate [] +synonym: "MOD_RES N,N,N-trimethylglycine" EXACT UniProt-feature [] +synonym: "N,N,N-trimethylglycine cation" EXACT RESID-alternate [] +synonym: "N,N,N-trimethylglycinium" EXACT RESID-alternate [] +synonym: "N2Me3+Gly" EXACT PSI-MOD-label [] +xref: DiffAvg: "43.09" +xref: DiffFormula: "C 3 H 7 N 0 O 0" +xref: DiffMono: "43.054775" +xref: Formula: "C 5 H 11 N 1 O 1" +xref: MassAvg: "101.15" +xref: MassMono: "101.084064" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00714 ! methylated glycine +is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue + +[Term] +id: MOD:01983 +name: N,N-dimethylglycine +def: "A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine." [ChEBI:17724, PubMed:23818633, PubMed:23978223, RESID:AA0620] +synonym: "(dimethylamino)ethanoic acid" EXACT RESID-systematic [] +synonym: "1-carboxy-N,N-dimethylaminomethane" EXACT RESID-alternate [] +synonym: "2-(dimethylamino)acetic acid" EXACT RESID-alternate [] +synonym: "MOD_RES N,N-dimethylglycine" EXACT UniProt-feature [] +synonym: "vitamin B16" EXACT RESID-alternate [] +xref: DiffAvg: "28.05" +xref: DiffFormula: "C 2 H 4 N 0 O 0" +xref: DiffMono: "28.031300" +xref: Formula: "C 4 H 8 N 1 O 1" +xref: MassAvg: "86.11" +xref: MassMono: "86.060589" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00714 ! methylated glycine +is_a: MOD:01686 ! alpha-amino dimethylated residue + +[Term] +id: MOD:01984 +name: 2-(L-cystein-S-yl)-L-alanine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine." [PubMed:21526839, RESID:AA0621] +comment: Cross-link 2. +synonym: "(2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic [] +synonym: "(2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid" EXACT RESID-alternate [] +synonym: "alpha-(L-cystein-S-yl)-L-alanine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 2 S 1" +xref: MassAvg: "172.20" +xref: MassMono: "172.030649" +xref: Origin: "A, C" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00901 ! modified L-alanine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01985 +name: 2-(L-cystein-S-yl)-D-asparagine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine." [PubMed:21786372, RESID:AA0622] +comment: Cross-link 2. +synonym: "(2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid" EXACT RESID-systematic [] +synonym: "alpha-(L-cystein-S-yl)-D-asparagine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 7 H 9 N 3 O 3 S 1" +xref: MassAvg: "215.23" +xref: MassMono: "215.036462" +xref: Origin: "C, N" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00903 ! modified L-asparagine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01986 +name: 2-(L-cystein-S-yl)-L-serine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine." [PubMed:21526839, RESID:AA0623] +comment: Cross-link 2. +synonym: "(2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid" EXACT RESID-systematic [] +synonym: "(2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 3 S 1" +xref: MassAvg: "188.20" +xref: MassMono: "188.025563" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01987 +name: 2-(L-cystein-S-yl)-D-serine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine." [PubMed:21786372, RESID:AA0624] +comment: Cross-link 2. +synonym: "(2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid" EXACT RESID-systematic [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 6 H 8 N 2 O 3 S 1" +xref: MassAvg: "188.20" +xref: MassMono: "188.025563" +xref: Origin: "C, S" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00916 ! modified L-serine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01988 +name: 2-(L-cystein-S-yl)-L-threonine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine." [PubMed:21526839, RESID:AA0625] +comment: Cross-link 2. +synonym: "(2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic [] +synonym: "(2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid" EXACT RESID-alternate [] +synonym: "alpha-(L-cystein-S-yl)-L-threonine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 7 H 10 N 2 O 3 S 1" +xref: MassAvg: "202.23" +xref: MassMono: "202.041213" +xref: Origin: "C, T" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00917 ! modified L-threonine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01989 +name: 2-(L-cystein-S-yl)-D-tyrosine +def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine." [PubMed:21526839, RESID:AA0626] +comment: Cross-link 2. +synonym: "(2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid" EXACT RESID-alternate [] +synonym: "(2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] +synonym: "alpha-(L-cystein-S-yl)-D-tyrosine" EXACT RESID-alternate [] +xref: DiffAvg: "-2.02" +xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" +xref: DiffMono: "-2.015650" +xref: Formula: "C 12 H 12 N 2 O 3 S 1" +xref: MassAvg: "264.30" +xref: MassMono: "264.056863" +xref: Origin: "C, Y" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00664 ! stereoisomerized residue +is_a: MOD:00919 ! modified L-tyrosine residue +is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues + +[Term] +id: MOD:01990 +name: protonated glycine (glycinium) residue +def: "A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine)." [ChEBI:64723, PubMed:18688235] +subset: PSI-MOD-slim +xref: DiffAvg: "1.01" +xref: DiffFormula: "C 0 H 1 N 0 O 0" +xref: DiffMono: "1.007276" +xref: FormalCharge: "1+" +xref: Formula: "C 2 H 5 N 1 O 1" +xref: MassAvg: "59.07" +xref: MassMono: "59.036565" +xref: Origin: "G" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:00908 ! modified glycine residue +is_a: MOD:01700 ! alpha-amino protonated residue + +[Term] +id: MOD:01991 +name: N,N,N-trimethylglycine (from glycinium) +def: "A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine." [ChEBI:17750, PubMed:23818633, PubMed:23978223, RESID:AA0619] +comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Gly process (MOD:01982) accounts for both protonation and trimethylation. +subset: PSI-MOD-slim +synonym: "N2Me3Gly" EXACT PSI-MOD-label [] +xref: DiffAvg: "42.08" +xref: DiffFormula: "C 3 H 6 N 0 O 0" +xref: DiffMono: "42.046402" +xref: FormalCharge: "1+" +xref: Formula: "C 5 H 11 N 1 O 1" +xref: MassAvg: "101.15" +xref: MassMono: "101.083515" +xref: Origin: "MOD:01990" +xref: Source: "natural" +xref: TermSpec: "N-term" +is_a: MOD:01687 ! alpha-amino trimethylated residue +relationship: derives_from MOD:01990 ! protonated glycine (glycinium) residue + +[Term] +id: MOD:01992 +name: alpha-carbon thioether crosslinked residues +def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue." [PubMed:18688235] +is_a: MOD:00687 ! thioether crosslinked residues + +[Term] +id: MOD:01993 +name: beta-carbon thioether crosslinked residues +def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue." [PubMed:18688235] +comment: These are typical lanthionine-like crosslinks. +is_a: MOD:00687 ! thioether crosslinked residues + +[Term] +id: MOD:01994 +name: N1'-formyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan." [PubMed:18688235] +comment: This modifications has not been reported as commonly encountered [JSG]. +synonym: "N1'FoTrp" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 12 H 10 N 2 O 2" +xref: MassAvg: "214.22" +xref: MassMono: "214.074228" +xref: Origin: "W" +xref: Source: "hypothetical" +xref: TermSpec: "none" +is_a: MOD:01106 ! N-formyl-L-tryptophan + +[Term] +id: MOD:01995 +name: N2-formyl-L-tryptophan +def: "A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan." [PubMed:18688235] +comment: This modifications has not been reported as commonly encountered [JSG]. +synonym: "N2FoTrp" EXACT PSI-MOD-label [] +xref: DiffAvg: "28.01" +xref: DiffFormula: "C 1 H 0 N 0 O 1" +xref: DiffMono: "27.994915" +xref: Formula: "C 12 H 11 N 2 O 2" +xref: MassAvg: "215.23" +xref: MassMono: "215.082053" +xref: Origin: "W" +xref: Source: "hypothetical" +xref: TermSpec: "N-term" +is_a: MOD:01106 ! N-formyl-L-tryptophan + +[Term] +id: MOD:01996 +name: butanoylated residue +def: "A protein modification that effectively replaces a hydrogen atom with an butanoyl group." [PubMed:18688235] +comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). +synonym: "ButRes" EXACT PSI-MOD-label [] +synonym: "Butyryl" RELATED UniMod-interim [] +synonym: "butyrylation" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:00649 ! acylated residue + +[Term] +id: MOD:01997 +name: N-butanoylated residue +def: "A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group." [PubMed:18688235] +synonym: "N-butanoyl" EXACT PSI-MOD-alternate [] +synonym: "N-butanoylation" EXACT PSI-MOD-alternate [] +synonym: "N-butyryl" EXACT PSI-MOD-alternate [] +synonym: "N-butyrylation" EXACT PSI-MOD-alternate [] +synonym: "NButRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 N 0 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "none" +xref: TermSpec: "none" +is_a: MOD:01996 ! butanoylated residue + +[Term] +id: MOD:01998 +name: alpha-amino butanoylated residue +def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group." [PubMed:18688235] +synonym: "N2ButRes" EXACT PSI-MOD-label [] +xref: DiffAvg: "70.09" +xref: DiffFormula: "C 4 H 6 N 0 O 1" +xref: DiffMono: "70.041865" +xref: Formula: "none" +xref: MassAvg: "none" +xref: MassMono: "none" +xref: Origin: "X" +xref: Source: "artifact" +xref: TermSpec: "N-term" +is_a: MOD:01997 ! N-butanoylated residue + +[Term] +id: MOD:01999 +name: N6-(11-cis)-retinylidene-L-lysine +def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine." [PubMed:18688235] +synonym: "(2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "266.43" +xref: DiffFormula: "C 20 H 26 N 0 O 0" +xref: DiffMono: "266.203451" +xref: Formula: "C 26 H 38 N 2 O 1" +xref: MassAvg: "394.60" +xref: MassMono: "394.298414" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:02000 ! N6-retinylidene-L-lysine (unspecified geometric isomer) + +[Term] +id: MOD:02000 +name: N6-retinylidene-L-lysine (unspecified geometric isomer) +def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer)." [PubMed:18688235] +synonym: "(2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT PSI-MOD-alternate [] +xref: DiffAvg: "266.43" +xref: DiffFormula: "C 20 H 26 N 0 O 0" +xref: DiffMono: "266.203451" +xref: Formula: "C 26 H 38 N 2 O 1" +xref: MassAvg: "394.60" +xref: MassMono: "394.298414" +xref: Origin: "K" +xref: Source: "natural" +xref: TermSpec: "none" +is_a: MOD:00912 ! modified L-lysine residue + +[Typedef] +id: contains +name: contains +def: "'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'." [PubMed:18688235] +comment: The inverse relationship to "part of". +is_transitive: true + +[Typedef] +id: derives_from +name: derives from +def: "'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'." [PubMed:18688235] +is_transitive: true + +[Typedef] +id: has_functional_parent +name: has functional parent +def: "'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification." [PubMed:18688235] +comment: This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent. +is_transitive: true + +[Typedef] +id: part_of +name: part of +def: "'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'." [PubMed:18688235] +is_transitive: true diff --git a/PSI-MOD.obo.xml b/PSI-MOD.obo.xml new file mode 100644 index 0000000..cc32133 --- /dev/null +++ b/PSI-MOD.obo.xml @@ -0,0 +1,149703 @@ + + + + file + PSI-MOD.obo + +
+ 1.2 + 30:05:2014 00:48 + John S. Garavelli + FormulaOBO.PL + + PSI-MOD-slim + subset of protein modifications + + + DeltaMass-label + Label from MS DeltaMass + + + OMSSA-label + Short label from OMSSA + + + PSI-MOD-alternate + Alternate name curated by PSI-MOD + + + PSI-MOD-label + Short label curated by PSI-MOD + + + PSI-MS-label + Agreed label from MS community + + + RESID-alternate + Alternate name from RESID + + + RESID-misnomer + Misnomer tagged alternate name from RESID + + + RESID-name + Name from RESID + + + RESID-systematic + Systematic name from RESID + + + UniMod-alternate + Alternate name from UniMod + + + UniMod-description + Description (full_name) from UniMod + + + UniMod-interim + Interim label from UniMod + + + UniProt-feature + Protein feature description from UniProtKB + + PSI-MOD + PSI-MOD version: 1.013.0 + RESID release: 75.00 + ISO-8601 date: 2014-01-28 14:22Z + Annotation note 1 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. + Annotation note 2 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". + Annotation note 3 - When an entry in the UniMod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the UniMod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". + Annotation note 4 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. + Annotation note 5 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. + Annotation note 6 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. + Annotation note 7 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". + Annotation note 8 - The DeltaMass listings for free amino acids have been removed. Most UniMod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. + Annotation note 9 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references. +
+ + MOD:00000 + protein modification + + Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModRes + PSI-MOD-label + + PSI-MOD + 1 + + + MOD:00001 + alkylated residue + + A protein modification that effectively replaces a hydrogen atom with an alkyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + AlkylRes + PSI-MOD-label + + + + Source + none + + MOD:01156 + PSI-MOD + + + MOD:00002 + O-glycosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-glycosylserine. + + 18688235 + PubMed + + + PSI-MOD-slim + + OGlycoSer + PSI-MOD-label + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00396 + MOD:00916 + PSI-MOD + + + MOD:00003 + UniMod + + Entry from UniMod. + + 18688235 + PubMed + + + This term is for organizational use only and should not be assigned. [JSG] + + + Source + none + + MOD:00032 + PSI-MOD + + + MOD:00004 + artifact + + Artifact entry from UniMod - OBSOLETE because organizational use is no longer required. + + 18688235 + PubMed + + + 1 + PSI-MOD + + + MOD:00005 + O-glycosyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine. + + 18688235 + PubMed + + + PSI-MOD-slim + + OGlycoThr + PSI-MOD-label + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00396 + MOD:00917 + PSI-MOD + + + MOD:00006 + N-glycosylated residue + + A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + NGlycoRes + PSI-MOD-label + + + + Source + none + + MOD:00693 + PSI-MOD + + + MOD:00007 + selenium substitution for sulfur + + A protein modification that effectively substitutes a selenium atom for a sulfur atom. + + 12148805 + PubMed + + + 162 + UniMod + + + + Delta:S(-1)Se(1) + PSI-MS-label + + + Se(S)Res + PSI-MOD-label + + + Selenium replaces sulphur + UniMod-description + + + + DiffAvg + 46.91 + + + + DiffFormula + C 0 H 0 N 0 O 0 S -1 Se 1 + + + + DiffMono + 47.944450 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00745 + PSI-MOD + + + MOD:00008 + common + + Entry from UniMod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required. + + 18688235 + PubMed + + + 1 + PSI-MOD + + + MOD:00009 + natural residue + + A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue. + + 6692818 + PubMed + + + AA0000 + RESID + + + PSI-MOD-slim + + alpha-amino acid + RESID-name + + + Res + PSI-MOD-label + + + + Origin + X + + + + Source + natural + + MOD:01157 + PSI-MOD + + + MOD:00010 + L-alanine residue + + A protein modification that effectively converts a source amino acid residue to an L-alanine. + + 29948 + ChEBI + + + 0 + DeltaMass + + + 6692818 + PubMed + + + AA0001 + RESID + + + PSI-MOD-slim + + (2S)-2-aminopropanoic acid + RESID-systematic + + + 2-aminopropionic acid + RESID-alternate + + + 2-azanylpropanoic acid + RESID-alternate + + + Ala + PSI-MOD-label + + + alpha-alanine + RESID-alternate + + + alpha-aminopropionic acid + RESID-alternate + + + L-alanine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + A + + + + Source + natural + + + + TermSpec + none + + MOD:00570 + MOD:00859 + MOD:01441 + PSI-MOD + + + MOD:00011 + L-arginine residue + + A protein modification that effectively converts a source amino acid residue to an L-arginine. + + 29952 + ChEBI + + + 0 + DeltaMass + + + 518876 + PubMed + + + 6692818 + PubMed + + + AA0002 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid + RESID-systematic + + + 2-amino-5-(carbamimidamido)pentanoic acid [tautomer] + RESID-alternate + + + 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer] + RESID-alternate + + + 2-amino-5-guanidinopentanoic acid + RESID-alternate + + + 2-amino-5-guanidinovaleric acid + RESID-alternate + + + 2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid + RESID-alternate + + + alpha-amino-delta-guanidinovaleric acid + RESID-alternate + + + Arg + PSI-MOD-label + + + L-arginine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 12 N 4 O 1 + + + + MassAvg + 156.19 + + + + MassMono + 156.101111 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00012 + L-asparagine residue + + A protein modification that effectively converts a source amino acid residue to an L-asparagine. + + 29956 + ChEBI + + + 0 + DeltaMass + + + 15736973 + PubMed + + + 5681232 + PubMed + + + 6692818 + PubMed + + + 9789001 + PubMed + + + AA0003 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-4-butanediamic acid + RESID-systematic + + + 2,4-bis(azanyl)-4-oxobutanoic acid + RESID-alternate + + + 2,4-diamino-4-oxobutanoic acid + RESID-alternate + + + 2-amino-3-carbamoylpropanoic acid + RESID-alternate + + + 2-amino-4-butanediamic acid + RESID-alternate + + + 2-aminosuccinamic acid + RESID-alternate + + + 2-aminosuccinic acid 4-amide + RESID-alternate + + + alpha-amino-beta-carbamylpropionic acid + RESID-alternate + + + alpha-aminosuccinamic acid + RESID-alternate + + + Asn + PSI-MOD-label + + + aspartic acid 4-amide + RESID-alternate + + + aspartic acid beta-amide + RESID-alternate + + + beta-asparagine + RESID-alternate + + + L-asparagine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 4 H 6 N 2 O 2 + + + + MassAvg + 114.10 + + + + MassMono + 114.042927 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:01441 + PSI-MOD + + + MOD:00013 + L-aspartic acid residue + + A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. + + 29958 + ChEBI + + + 0 + DeltaMass + + + 1097438 + PubMed + + + 339692 + PubMed + + + 4399050 + PubMed + + + 5764436 + PubMed + + + 6692818 + PubMed + + + 8089117 + PubMed + + + 9521123 + PubMed + + + 9582379 + PubMed + + + AA0004 + RESID + + + PSI-MOD-slim + + (2S)-2-aminobutanedioic acid + RESID-systematic + + + 2-azanylbutanedioic acid + RESID-alternate + + + aminosuccinic acid + RESID-alternate + + + Asp + PSI-MOD-label + + + L-aspartic acid + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:01441 + PSI-MOD + + + MOD:00014 + L-cysteine residue + + A protein modification that effectively converts a source amino acid residue to an L-cysteine. + + 29950 + ChEBI + + + 0 + DeltaMass + + + 1310545 + PubMed + + + 15790858 + PubMed + + + 3447159 + PubMed + + + 6692818 + PubMed + + + 7338899 + PubMed + + + AA0005 + RESID + + + From DeltaMass: Average Mass: 121. + PSI-MOD-slim + + (2R)-2-amino-3-sulfanylpropanoic acid + RESID-systematic + + + (R)-cysteine + RESID-alternate + + + 2-amino-3-mercaptopropanoic acid + RESID-alternate + + + 2-amino-3-mercaptopropionic acid + RESID-alternate + + + 2-azanyl-3-sulfanylpropanoic acid + RESID-alternate + + + 3-mercapto-L-alanine + RESID-alternate + + + alpha-amino-beta-mercaptopropanoic acid + RESID-alternate + + + alpha-amino-beta-mercaptopropionic acid + RESID-alternate + + + alpha-amino-beta-thiolpropionic acid + RESID-alternate + + + beta-mercaptoalanine + RESID-alternate + + + Cys + PSI-MOD-label + + + Cysteine (C, Cys) + DeltaMass-label + + + half-cystine + RESID-alternate + + + L-(+)-cysteine + RESID-alternate + + + L-cysteine + RESID-name + + + thioserine + RESID-alternate + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 S 0 + + + + DiffMono + 0.000000 + + + + Formula + C 3 H 5 N 1 O 1 S 1 + + + + MassAvg + 103.14 + + + + MassMono + 103.009185 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:01441 + PSI-MOD + + + MOD:00015 + L-glutamic acid residue + + A protein modification that effectively converts a source amino acid residue to an L-glutamic acid. + + 29972 + ChEBI + + + 0 + DeltaMass + + + 1881881 + PubMed + + + 4565668 + PubMed + + + 4922541 + PubMed + + + 6692818 + PubMed + + + 9326660 + PubMed + + + 957425 + PubMed + + + AA0006 + RESID + + + PSI-MOD-slim + + (2S)-2-aminopentanedioic acid + RESID-systematic + + + 1-aminopropane-1,3-dicarboxylic acid + RESID-alternate + + + 2-aminoglutaric acid + RESID-alternate + + + 2-azanylpentanedioic acid + RESID-alternate + + + alpha-aminoglutaric acid + RESID-alternate + + + Glu + PSI-MOD-label + + + glutaminic acid + RESID-alternate + + + L-glutamic acid + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:01441 + PSI-MOD + + + MOD:00016 + L-glutamine residue + + A protein modification that effectively converts a source amino acid residue to an L-glutamine. + + 30011 + ChEBI + + + 0 + DeltaMass + + + 3340166 + PubMed + + + 6692818 + PubMed + + + 9342308 + PubMed + + + AA0007 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-5-pentanediamic acid + RESID-systematic + + + 2,5-bis(azanyl)-5-oxopentanoic acid + RESID-alternate + + + 2,5-diamino-5-oxopentanoic acid + RESID-alternate + + + 2-amino-4-carbamoylbutanoic acid + RESID-alternate + + + 2-aminoglutaramic acid + RESID-alternate + + + alpha-amino-gamma-carbamylbutyric acid + RESID-alternate + + + Gln + PSI-MOD-label + + + glutamic acid 5-amide + RESID-alternate + + + glutamic acid gamma-amide + RESID-alternate + + + glutamide + RESID-alternate + + + L-glutamine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 8 N 2 O 2 + + + + MassAvg + 128.13 + + + + MassMono + 128.058578 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00894 + MOD:01441 + PSI-MOD + + + MOD:00017 + glycine residue + + A protein modification that effectively converts a source amino acid residue to a glycine. + + 29947 + ChEBI + + + 0 + DeltaMass + + + 1310545 + PubMed + + + 6692818 + PubMed + + + AA0008 + RESID + + + PSI-MOD-slim + + aminoacetic acid + RESID-alternate + + + aminoethanoic acid + RESID-systematic + + + azanylethanoic acid + RESID-alternate + + + Gly + PSI-MOD-label + + + glycine + RESID-name + + + glycocoll + RESID-alternate + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 2 H 3 N 1 O 1 + + + + MassAvg + 57.05 + + + + MassMono + 57.021464 + + + + Origin + G + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00018 + L-histidine residue + + A protein modification that effectively converts a source amino acid residue to an L-histidine. + + 29979 + ChEBI + + + 0 + DeltaMass + + + 14342316 + PubMed + + + 2722967 + PubMed + + + 512 + PubMed + + + 5460889 + PubMed + + + 6129252 + PubMed + + + 6692818 + PubMed + + + 6876174 + PubMed + + + AA0009 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid + RESID-systematic + + + (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer] + RESID-alternate + + + 2-azanyl-3-(1H-imidazol-4-yl)propanoic acid + RESID-alternate + + + 2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer] + RESID-alternate + + + 4-(2-amino-2-carboxyethyl)imidazole + RESID-alternate + + + alpha-amino-beta-(4-imidazole)propionic acid + RESID-alternate + + + glyoxaline-5-alanine + RESID-alternate + + + His + PSI-MOD-label + + + L-histidine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 7 N 3 O 1 + + + + MassAvg + 137.14 + + + + MassMono + 137.058912 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00019 + L-isoleucine residue + + A protein modification that effectively converts a source amino acid residue to an L-isoleucine. + + 30009 + ChEBI + + + 0 + DeltaMass + + + 6692818 + PubMed + + + AA0010 + RESID + + + PSI-MOD-slim + + (2S,3S)-2-amino-3-methylpentanoic acid + RESID-systematic + + + 2-azanyl-3-methylpentanoic acid + RESID-alternate + + + 3-methyl-norvaline + RESID-alternate + + + alpha-amino-beta-methylvaleric acid + RESID-alternate + + + Ile + PSI-MOD-label + + + Isoleucyl + DeltaMass-label + + + L-erythro-isoleucine + RESID-alternate + + + L-isoleucine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00306 + MOD:01441 + PSI-MOD + + + MOD:00020 + L-leucine residue + + A protein modification that effectively converts a source amino acid residue to an L-leucine. + + 30006 + ChEBI + + + 0 + DeltaMass + + + 11478885 + PubMed + + + 6692818 + PubMed + + + AA0011 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-4-methylpentanoic acid + RESID-systematic + + + 2-azanyl-4-methylpentanoic acid + RESID-alternate + + + 4-methyl-norvaline + RESID-alternate + + + alpha-amino-gamma-methylvaleric acid + RESID-alternate + + + alpha-aminoisocaproic acid + RESID-alternate + + + L-leucine + RESID-name + + + Leu + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:00306 + MOD:01441 + PSI-MOD + + + MOD:00021 + L-lysine residue + + A protein modification that effectively converts a source amino acid residue to L-lysine. + + 29967 + ChEBI + + + 0 + DeltaMass + + + 3106962 + PubMed + + + 6120171 + PubMed + + + 6692818 + PubMed + + + AA0012 + RESID + + + PSI-MOD-slim + + (2S)-2,6-diaminohexanoic acid + RESID-systematic + + + 2,6-bis(azanyl)hexanoic acid + RESID-alternate + + + 6-amino-L-norleucine + RESID-alternate + + + ACT_SITE Schiff-base intermediate with substrate + UniProt-feature + + + alpha,epsilon-diaminocaproic acid + RESID-alternate + + + L-lysine + RESID-name + + + Lys + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 12 N 2 O 1 + + + + MassAvg + 128.18 + + + + MassMono + 128.094963 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00893 + MOD:01441 + PSI-MOD + + + MOD:00022 + L-methionine residue + + A protein modification that effectively converts a source amino acid residue to L-methionine. + + 29983 + ChEBI + + + 0 + DeltaMass + + + 6411710 + PubMed + + + 6692818 + PubMed + + + AA0013 + RESID + + + From DeltaMass: Average Mass: 149 + PSI-MOD-slim + + (2S)-2-amino-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-amino-4-(methylthio)butanoic acid + RESID-alternate + + + 2-amino-4-(methylthio)butyric acid + RESID-alternate + + + 2-azanyl-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + alpha-amino-gamma-methylmercaptobutyric acid + RESID-alternate + + + alpha-amino-gamma-methylthiobutyric acid + RESID-alternate + + + gamma-methylthio-alpha-aminobutyric acid + RESID-alternate + + + L-(-)-methionine + RESID-alternate + + + L-methionine + RESID-name + + + Met + PSI-MOD-label + + + S-methyl-L-homocysteine + RESID-alternate + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 S 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 131.19 + + + + MassMono + 131.040485 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00023 + L-phenylalanine residue + + A protein modification that effectively converts a source amino acid residue to L-phenylalanine. + + 29997 + ChEBI + + + 0 + DeltaMass + + + 6692818 + PubMed + + + AA0014 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-phenylpropanoic acid + RESID-systematic + + + 2-azanyl-3-phenylpropanoic acid + RESID-alternate + + + alpha-amino-beta-phenylpropionic acid + RESID-alternate + + + L-phenylalanine + RESID-name + + + Phe + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 9 H 9 N 1 O 1 + + + + MassAvg + 147.18 + + + + MassMono + 147.068414 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00024 + L-proline residue + + A protein modification that effectively converts a source amino acid residue to L-proline. + + 30017 + ChEBI + + + 0 + DeltaMass + + + 6692818 + PubMed + + + 8547259 + PubMed + + + AA0015 + RESID + + + PSI-MOD-slim + + (2S)-2-pyrrolidinecarboxylic acid + RESID-systematic + + + L-proline + RESID-name + + + Pro + PSI-MOD-label + + + pyrrolidine-2-carboxylic acid + RESID-alternate + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 7 N 1 O 1 + + + + MassAvg + 97.12 + + + + MassMono + 97.052764 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00025 + L-serine residue + + A protein modification that effectively converts a source amino acid residue to L-serine. + + 29999 + ChEBI + + + 0 + DeltaMass + + + 4399050 + PubMed + + + 6692818 + PubMed + + + AA0016 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-hydroxypropanoic acid + RESID-systematic + + + 2-azanyl-3-hydroxypropanoic acid + RESID-alternate + + + 3-hydroxy-L-alanine + RESID-alternate + + + alpha-amino-beta-hydroxypropionic acid + RESID-alternate + + + beta-hydroxyalanine + RESID-alternate + + + L-serine + RESID-name + + + Ser + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 3 H 5 N 1 O 2 + + + + MassAvg + 87.08 + + + + MassMono + 87.032028 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00026 + L-threonine residue + + A protein modification that effectively converts a source amino acid residue to L-threonine. + + 30013 + ChEBI + + + 0 + DeltaMass + + + 2989287 + PubMed + + + 6692818 + PubMed + + + AA0017 + RESID + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-hydroxybutanoic acid + RESID-systematic + + + 2-azanyl-3-hydroxybutanoic acid + RESID-alternate + + + alpha-amino-beta-hydroxybutyric acid + RESID-alternate + + + beta-methylserine + RESID-alternate + + + L-threo-threonine + RESID-alternate + + + L-threonine + RESID-name + + + Thr + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 4 H 7 N 1 O 2 + + + + MassAvg + 101.10 + + + + MassMono + 101.047678 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00027 + L-tryptophan residue + + A protein modification that effectively converts a source amino acid residue to L-tryptophan. + + 29954 + ChEBI + + + 0 + DeltaMass + + + 2059637 + PubMed + + + 6692818 + PubMed + + + 9324768 + PubMed + + + AA0018 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid + RESID-systematic + + + 2-azanyl-3-(1H-indol-3-yl)propanoic acid + RESID-alternate + + + alpha-amino-beta-(3-indolyl)propionoic acid + RESID-alternate + + + beta(3-indolyl)alanine + RESID-alternate + + + L-tryptophan + RESID-name + + + Trp + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 11 H 10 N 2 O 1 + + + + MassAvg + 186.21 + + + + MassMono + 186.079313 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00028 + L-tyrosine residue + + A protein modification that effectively converts a source amino acid residue to L-tyrosine. + + 29975 + ChEBI + + + 0 + DeltaMass + + + 2190093 + PubMed + + + 2542938 + PubMed + + + 5550972 + PubMed + + + 6061414 + PubMed + + + 6120171 + PubMed + + + 6692818 + PubMed + + + AA0019 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid + RESID-systematic + + + 2-azanyl-3-(4-hydoxyphenyl)propanoic acid + RESID-alternate + + + alpha-amino-beta-(para-hydroxyphenyl)propionic acid + RESID-alternate + + + L-tyrosine + RESID-name + + + p-tyrosine + RESID-alternate + + + para-hydroxyphenylalanine + RESID-alternate + + + Tyr + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 9 H 9 N 1 O 2 + + + + MassAvg + 163.18 + + + + MassMono + 163.063329 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00029 + L-valine residue + + A protein modification that effectively converts a source amino acid residue to an L-valine. + + 30015 + ChEBI + + + 0 + DeltaMass + + + 6692818 + PubMed + + + AA0020 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-methylbutanoic acid + RESID-systematic + + + 2-azanyl-3-methylbutanoic acid + RESID-alternate + + + alpha-amino-beta-methylbutyric acid + RESID-alternate + + + alpha-aminoisovaleric acid + RESID-alternate + + + L-valine + RESID-name + + + Val + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 9 N 1 O 1 + + + + MassAvg + 99.13 + + + + MassMono + 99.068414 + + + + Origin + V + + + + Source + natural + + + + TermSpec + none + + MOD:01441 + PSI-MOD + + + MOD:00030 + N-formyl-L-methionine residue + + A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification. + + 33718 + ChEBI + + + 10825024 + PubMed + + + 11152118 + PubMed + + + 2165784 + PubMed + + + 3042771 + PubMed + + + 8758896 + PubMed + + + AA0021#FMET + RESID + + + 107#N-term + UniMod + + + PSI-MOD-slim + + (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-formamido-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + 2-formylamino-4-(methylthio)butanoic acid + RESID-alternate + + + 2-formylazanyl-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + Addition of N-formyl met + UniMod-description + + + fMet + PSI-MOD-label + + + FormylMet + PSI-MS-label + + + MOD_RES N-formylmethionine + UniProt-feature + + + N-formyl-L-methionine + RESID-name + + + N-formylated L-methionine + PSI-MOD-alternate + + + nformylmet + OMSSA-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 S 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 10 N 1 O 2 S 1 + + + + MassAvg + 160.21 + + + + MassMono + 160.043225 + + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:00409 + MOD:00868 + MOD:01696 + PSI-MOD + + + MOD:00031 + L-selenocysteine residue + + A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification. + + 30000 + ChEBI + + + 10523135 + PubMed + + + 1066676 + PubMed + + + 2037562 + PubMed + + + 2963330 + PubMed + + + 4734725 + PubMed + + + 6076213 + PubMed + + + 6217842 + PubMed + + + 6714945 + PubMed + + + AA0022 + RESID + + + PSI-MOD-slim + + (2R)-2-amino-3-selanylpropanoic acid + RESID-systematic + + + 2-azanyl-3-selanylpropanoic acid + RESID-alternate + + + 3-selenylalanine + RESID-alternate + + + L-selenocysteine + RESID-name + + + NON_STD Selenocysteine + UniProt-feature + + + Sec + PSI-MOD-label + + + SeCys + RESID-alternate + + + selenium cysteine + RESID-alternate + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 Se 0 + + + + DiffMono + 0.000000 + + + + Formula + C 3 H 5 N 1 O 1 Se 1 + + + + MassAvg + 150.05 + + + + MassMono + 150.953635 + + + + Origin + U + + + + Source + natural + + + + TermSpec + none + + MOD:00745 + MOD:00859 + MOD:00868 + PSI-MOD + + + MOD:00032 + uncategorized protein modification + + A protein modification that is not chemically categorized. + + 18688235 + PubMed + + + This term is for organizational use only and should not be assigned. [JSG] + + + Source + none + + MOD:00000 + PSI-MOD + + + MOD:00033 + crosslinked residues + + A protein modification that crosslinks two or more amino acid residues with covalent bonds. + + 18688235 + PubMed + + + The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. + PSI-MOD-slim + + XLNK-Res-Res + PSI-MOD-label + + + + Source + none + + MOD:01156 + PSI-MOD + + + MOD:00034 + L-cystine (cross-link) + + A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. + + 16283 + ChEBI + + + 0 + DeltaMass + + + 1988019 + PubMed + + + 2001356 + PubMed + + + 2076469 + PubMed + + + 3083866 + PubMed + + + 366603 + PubMed + + + 7918467 + PubMed + + + 8344916 + PubMed + + + AA0025#CYS2 + RESID + + + Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. + PSI-MOD-slim + + (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) + RESID-systematic + + + 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid + RESID-misnomer + + + 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) + RESID-alternate + + + 3,3'-dithiobis(2-aminopropanoic acid) + RESID-alternate + + + 3,3'-dithiobisalanine + RESID-alternate + + + 3,3'-dithiodialanine + RESID-alternate + + + beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide + RESID-alternate + + + beta,beta'-dithiodialanine + RESID-alternate + + + bis(alpha-aminopropionic acid)-beta-disulfide + RESID-alternate + + + bis(beta-amino-beta-carboxyethyl)disulfide + RESID-alternate + + + Cys2 + PSI-MOD-label + + + Cystine ((Cys)2) + DeltaMass-label + + + dicysteine + RESID-alternate + + + DISULFID + UniProt-feature + + + DISULFID Interchain + UniProt-feature + + + L-cystine + RESID-name + + + XLNK-SCys-SCys + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 2 S 2 + + + + MassAvg + 204.26 + + + + MassMono + 204.002720 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00689 + PSI-MOD + + + MOD:00035 + (2S,3R)-3-hydroxyasparagine + + A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine. + + 11823643 + PubMed + + + 2820791 + PubMed + + + AA0026 + RESID + + + PSI-MOD-slim + + (2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid + RESID-alternate + + + (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid + RESID-systematic + + + (2S,3R)-3-hydroxyasparagine + RESID-name + + + (3R)3HyAsn + PSI-MOD-label + + + 2-azanyl-3-hydroxy-4-butanediamic acid + RESID-alternate + + + erythro-beta-hydroxylated L-asparagine + PSI-MOD-alternate + + + L-erythro-beta-hydroxyasparagine + RESID-alternate + + + MOD_RES (3R)-3-hydroxyasparagine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 4 H 6 N 2 O 3 + + + + MassAvg + 130.10 + + + + MassMono + 130.037842 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:01688 + PSI-MOD + + + MOD:00036 + (2S,3R)-3-hydroxyaspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid. + + 6572939 + PubMed + + + 6871167 + PubMed + + + 8355279 + PubMed + + + AA0027 + RESID + + + 35#D + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-hydroxybutanedioic acid + RESID-systematic + + + (2S,3R)-3-hydroxyaspartic acid + RESID-name + + + (3R)3HyAsp + PSI-MOD-label + + + 2-amino-3-hydroxysuccinic acid + RESID-alternate + + + 2-azanyl-3-hydroxybutanedioic acid + RESID-alternate + + + 3-hydroxyaspartic acid + RESID-alternate + + + erythro-beta-hydroxylated L-aspartic acid + PSI-MOD-alternate + + + hydroxylationd + OMSSA-label + + + L-erythro-beta-hydroxyaspartic acid + RESID-alternate + + + MOD_RES (3R)-3-hydroxyaspartate + UniProt-feature + + + Oxidation + PSI-MS-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 4 H 5 N 1 O 4 + + + + MassAvg + 131.09 + + + + MassMono + 131.021858 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:01926 + PSI-MOD + + + MOD:00037 + 5-hydroxy-L-lysine + + A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues. + + 60175 + ChEBI + + + 18688235 + PubMed + + + PSI-MOD-slim + + 5-hydroxylated L-lysine + PSI-MOD-alternate + + + 5HyLys + PSI-MOD-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 2 O 2 + + + + MassAvg + 144.17 + + + + MassMono + 144.089878 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01047 + PSI-MOD + + + MOD:00038 + 3-hydroxy-L-proline + + A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. + + 16889 + ChEBI + + + 2400108 + PubMed + + + 3734192 + PubMed + + + 4343807 + PubMed + + + AA0029 + RESID + + + PSI-MOD-slim + + (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid + RESID-systematic + + + 3-hydroxy-L-proline + RESID-name + + + 3-hydroxylated L-proline + PSI-MOD-alternate + + + 3-trans-hydroxy-L-proline + RESID-alternate + + + 3HyPro + PSI-MOD-label + + + beta-hydroxypyrrolidine-alpha-carboxylic acid + RESID-alternate + + + L-threo-3-hydroxyproline + RESID-alternate + + + MOD_RES 3-hydroxyproline + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:01024 + PSI-MOD + + + MOD:00039 + 4-hydroxy-L-proline + + A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline + + 18095 + ChEBI + + + 11292863 + PubMed + + + 2400108 + PubMed + + + 3734192 + PubMed + + + AA0030 + RESID + + + PSI-MOD-slim + + (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid + RESID-systematic + + + 4-hydroxy-L-proline + RESID-name + + + 4-hydroxylated L-proline + PSI-MOD-alternate + + + 4-hydroxyproline + RESID-alternate + + + 4-trans-hydroxy-L-proline + RESID-alternate + + + 4HyPro + PSI-MOD-label + + + gamma-hydroxypyrrolidine-alpha-carboxylic acid + RESID-alternate + + + L-threo-4-hydroxyproline + RESID-alternate + + + MOD_RES 4-hydroxyproline + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:01024 + PSI-MOD + + + MOD:00040 + 2-pyrrolidone-5-carboxylic acid (Gln) + + A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. + + 30652 + ChEBI + + + 123 + DeltaMass + + + 10214721 + PubMed + + + 1836357 + PubMed + + + 26343 + PubMed + + + 3473473 + PubMed + + + AA0031#GLN + RESID + + + 28#Q + UniMod + + + DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 + PSI-MOD-slim + + (2S)-5-oxo-2-pyrrolidinecarboxylic acid + RESID-systematic + + + 2-oxopyrrolidine-5-carboxylic acid + RESID-alternate + + + 2-pyrrolidone-5-carboxylic acid + RESID-name + + + 5-oxoproline + RESID-alternate + + + 5-oxopyrrolidine-2-carboxylic acid + RESID-alternate + + + 5-pyrrolidone-2-carboxylic acid + RESID-alternate + + + Gln->pyro-Glu + PSI-MS-label + + + MOD_RES Pyrrolidone carboxylic acid + UniProt-feature + + + N-pyrrolidone carboxyl (N terminus) + DeltaMass-label + + + ntermpeppyroq + OMSSA-label + + + PCA + RESID-alternate + + + PyrGlu(Gln) + PSI-MOD-label + + + Pyro-glu from Q + UniMod-description + + + pyroglutamic acid + RESID-alternate + + + Pyroglutamic Acid formed from Gln + DeltaMass-label + + + Pyroglutamyl + DeltaMass-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 5 H 6 N 1 O 2 + + + + MassAvg + 112.11 + + + + MassMono + 112.039853 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + N-term + + MOD:00907 + MOD:01048 + MOD:01160 + PSI-MOD + + + MOD:00041 + L-gamma-carboxyglutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. + + 217 + DeltaMass + + + 10517147 + PubMed + + + 1807167 + PubMed + + + 3263814 + PubMed + + + 4528109 + PubMed + + + 7457858 + PubMed + + + 8135347 + PubMed + + + 8868490 + PubMed + + + 9188685 + PubMed + + + AA0032 + RESID + + + 299#E + UniMod + + + DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173. + PSI-MOD-slim + + (3S)-3-aminopropane-1,1,3-tricarboxylic acid + RESID-systematic + + + (3S)-3-azanylpropane-1,1,3-tricarboxylic acid + RESID-alternate + + + 1-carboxyglutamic acid + RESID-misnomer + + + 3-amino-1,1,3-propanetricarboxylic acid + RESID-alternate + + + 3-azanylpropane-1,1,3-tricarboxylic acid + RESID-alternate + + + 4-carboxyglutamic acid + RESID-alternate + + + 4CbxGlu + PSI-MOD-label + + + Carboxy + PSI-MS-label + + + Carboxy + UniMod-interim + + + Carboxy Glutamyl + DeltaMass-label + + + Carboxylation + UniMod-description + + + gamma-carboxylated L-glutamic acid + PSI-MOD-alternate + + + gammacarboxyle + OMSSA-label + + + L-gamma-carboxyglutamic acid + RESID-name + + + MOD_RES 4-carboxyglutamate + UniProt-feature + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 + + + + DiffMono + 43.989829 + + + + Formula + C 6 H 7 N 1 O 5 + + + + MassAvg + 173.12 + + + + MassMono + 173.032422 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + MOD:01152 + PSI-MOD + + + MOD:00042 + L-aspartic 4-phosphoric anhydride + + A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. + + 15836 + ChEBI + + + 4357737 + PubMed + + + AA0033 + RESID + + + 21#D + UniMod + + + + (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid + RESID-systematic + + + 2-aminobutanedioic 4-phosphoric anhydride + RESID-alternate + + + 2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid + RESID-alternate + + + 4-oxo-O-phosphono-L-homoserine + RESID-alternate + + + 4-phosphoaspartic acid + RESID-alternate + + + 4-phosphorylated L-aspartatic acid + PSI-MOD-alternate + + + ACT_SITE 4-aspartylphosphate intermediate + UniProt-feature + + + beta-aspartyl phosphate + RESID-alternate + + + L-aspartic 4-phosphoric anhydride + RESID-name + + + MOD_RES 4-aspartylphosphate + UniProt-feature + + + PAsp + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phosphorylation + UniMod-description + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 4 H 6 N 1 O 6 P 1 + + + + MassAvg + 195.07 + + + + MassMono + 194.993274 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01455 + PSI-MOD + + + MOD:00043 + S-phospho-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. + + 3142516 + PubMed + + + 7961745 + PubMed + + + 8128219 + PubMed + + + AA0034 + RESID + + + 21#C + UniMod + + + + (2R)-2-amino-3-(phosphonosulfanyl)propanoic acid + RESID-systematic + + + 2-azanyl-3-(phosphonosulfanyl)propanoic acid + RESID-alternate + + + ACT_SITE Phosphocysteine intermediate + UniProt-feature + + + cysteine phosphate thioester + RESID-alternate + + + MOD_RES Phosphocysteine + UniProt-feature + + + PCys + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phosphorylation + UniMod-description + + + S-phospho-L-cysteine + RESID-name + + + S-phosphonocysteine + RESID-alternate + + + S-phosphorylated L-cysteine + PSI-MOD-alternate + + + S3-phosphocysteine + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 S 0 + + + + DiffMono + 79.966331 + + + + Formula + C 3 H 6 N 1 O 4 P 1 S 1 + + + + MassAvg + 183.12 + + + + MassMono + 182.975515 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00696 + MOD:00777 + MOD:00905 + PSI-MOD + + + MOD:00044 + 1'-phospho-L-histidine + + A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine). + + 11038361 + PubMed + + + 5642389 + PubMed + + + 6692818 + PubMed + + + AA0035 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid + RESID-systematic + + + 1'-phospho-L-histidine + RESID-name + + + 2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid + RESID-alternate + + + ACT_SITE Tele-phosphohistidine intermediate + UniProt-feature + + + histidine-3-phosphate + RESID-misnomer + + + histidine-N(epsilon)-phosphate + RESID-alternate + + + histidine-N1'-phosphate + RESID-alternate + + + MOD_RES Tele-phosphohistidine + UniProt-feature + + + N(tau)-phosphohistidine + RESID-alternate + + + N1-phosphonohistidine + RESID-alternate + + + NE2-phosphonohistidine + RESID-alternate + + + Ntau-phosphorylated L-histidine + PSI-MOD-alternate + + + NtPHis + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phosphorylation + UniMod-description + + + tele-phosphohistidine + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 6 H 8 N 3 O 4 P 1 + + + + MassAvg + 217.12 + + + + MassMono + 217.025242 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00890 + PSI-MOD + + + MOD:00045 + 3'-phospho-L-histidine + + A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine). + + 1549615 + PubMed + + + 5642389 + PubMed + + + 6692818 + PubMed + + + 7669763 + PubMed + + + 7803390 + PubMed + + + AA0036 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid + RESID-systematic + + + 2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid + RESID-alternate + + + 3'-phospho-L-histidine + RESID-name + + + ACT_SITE Pros-phosphohistidine intermediate + UniProt-feature + + + histidine-1-phosphate + RESID-misnomer + + + histidine-N(delta)-phosphate + RESID-alternate + + + histidine-N3'-phosphate + RESID-alternate + + + MOD_RES Pros-phosphohistidine + UniProt-feature + + + N(pi)-phosphohistidine + RESID-alternate + + + N3-phosphonohistidine + RESID-alternate + + + ND1-phosphonohistidine + RESID-alternate + + + Npi-phosphorylated L-histidine + PSI-MOD-alternate + + + NpPHis + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phosphorylation + UniMod-description + + + pros-phosphohistidine + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 6 H 8 N 3 O 4 P 1 + + + + MassAvg + 217.12 + + + + MassMono + 217.025242 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00890 + PSI-MOD + + + MOD:00046 + O-phospho-L-serine + + A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. + + 15811 + ChEBI + + + 0 + DeltaMass + + + 12923550 + PubMed + + + 4065410 + PubMed + + + 8061611 + PubMed + + + AA0037 + RESID + + + 21#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(phosphonooxy)propanoic acid + RESID-systematic + + + 2-amino-3-hydroxypropanoic acid 3-phosphate + RESID-alternate + + + 2-azanyl-3-(phosphonooxy)propanoic acid + RESID-alternate + + + ACT_SITE Phosphoserine intermediate + UniProt-feature + + + MOD_RES Phosphoserine + UniProt-feature + + + O-phospho-L-serine + RESID-name + + + O-phosphonoserine + RESID-alternate + + + O-phosphorylated L-serine + PSI-MOD-alternate + + + O3-phosphoserine + RESID-alternate + + + OPSer + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phospho Seryl + DeltaMass-label + + + Phosphorylation + UniMod-description + + + phosphorylations + OMSSA-label + + + serine phosphate ester + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 3 H 6 N 1 O 5 P 1 + + + + MassAvg + 167.06 + + + + MassMono + 166.998359 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00771 + MOD:00916 + MOD:01455 + PSI-MOD + + + MOD:00047 + O-phospho-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. + + 21967 + ChEBI + + + 0 + DeltaMass + + + 12923550 + PubMed + + + 7678926 + PubMed + + + AA0038 + RESID + + + 21#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid + RESID-systematic + + + 2-amino-3-hydroxybutanoic acid 3-phosphate + RESID-alternate + + + 2-azanyl-3-(phosphonooxy)butanoic acid + RESID-alternate + + + MOD_RES Phosphothreonine + UniProt-feature + + + O-phospho-L-threonine + RESID-name + + + O-phosphorylated L-threonine + PSI-MOD-alternate + + + O3-phosphothreonine + RESID-alternate + + + OPThr + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phospho Threonyl + DeltaMass-label + + + Phosphorylation + UniMod-description + + + phosphorylationt + OMSSA-label + + + threonine phosphate ester + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 4 H 8 N 1 O 5 P 1 + + + + MassAvg + 181.08 + + + + MassMono + 181.014009 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00773 + MOD:00917 + MOD:01455 + PSI-MOD + + + MOD:00048 + O4'-phospho-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. + + 0 + DeltaMass + + + 10226369 + PubMed + + + 1725475 + PubMed + + + AA0039 + RESID + + + 21#Y + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid + RESID-systematic + + + 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate + RESID-alternate + + + 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid + RESID-alternate + + + MOD_RES Phosphotyrosine + UniProt-feature + + + O4'-phospho-L-tyrosine + RESID-name + + + O4'-phosphorylated L-tyrosine + PSI-MOD-alternate + + + O4-phosphotyrosine + RESID-alternate + + + OPTyr + PSI-MOD-label + + + Phospho + PSI-MS-label + + + Phospho Tyrosinyl + DeltaMass-label + + + Phosphorylation + UniMod-description + + + phosphorylationy + OMSSA-label + + + tyrosine phosphate + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 9 H 10 N 1 O 5 P 1 + + + + MassAvg + 243.15 + + + + MassMono + 243.029659 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00774 + MOD:00919 + MOD:01455 + PSI-MOD + + + MOD:00049 + 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine + + A protein modification that effectively converts an L-histidine residue to diphthamide. + + 16692 + ChEBI + + + 122 + DeltaMass + + + 15316019 + PubMed + + + 7430147 + PubMed + + + AA0040 + RESID + + + 375#H + UniMod + + + + (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium + RESID-systematic + + + (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium + RESID-alternate + + + 1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium + RESID-alternate + + + 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine + RESID-name + + + 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole + RESID-alternate + + + 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine + RESID-alternate + + + 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid + RESID-alternate + + + 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide + RESID-alternate + + + alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium + RESID-alternate + + + Diphth + PSI-MOD-label + + + Diphthamide + PSI-MS-label + + + Diphthamide + UniMod-description + + + diphthamide + RESID-alternate + + + diphthamide (from histidine) + DeltaMass-label + + + MOD_RES Diphthamide + UniProt-feature + + + + DiffAvg + 143.21 + + + + DiffFormula + C 7 H 15 N 2 O 1 + + + + DiffMono + 143.117890 + + + + FormalCharge + 1+ + + + + Formula + C 13 H 22 N 5 O 2 + + + + MassAvg + 280.35 + + + + MassMono + 280.176801 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + PSI-MOD + + + MOD:00050 + N-acetyl-L-alanine + + A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. + + 363452 + PubMed + + + 4700463 + PubMed + + + AA0041 + RESID + + + PSI-MOD-slim + + (2S)-2-(acetamido)propanoic acid + RESID-systematic + + + 2-(acetylamino)propanoic acid + RESID-alternate + + + 2-(acetylazanyl)propanoic acid + RESID-alternate + + + AcAla + PSI-MOD-label + + + acetylalanine + RESID-alternate + + + MOD_RES N-acetylalanine + UniProt-feature + + + N-acetyl-L-alanine + RESID-name + + + N-acetylated L-alanine + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 5 H 8 N 1 O 2 + + + + MassAvg + 114.12 + + + + MassMono + 114.055504 + + + + Origin + A + + + + Source + natural + + + + TermSpec + N-term + + MOD:00901 + MOD:01458 + PSI-MOD + + + MOD:00051 + N-acetyl-L-aspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. + + 21547 + ChEBI + + + 1560020 + PubMed + + + 2395459 + PubMed + + + AA0042 + RESID + + + PSI-MOD-slim + + (2S)-2-(acetamido)butanedioic acid + RESID-systematic + + + 2-(acetylamino)butanedioic acid + RESID-alternate + + + 2-(acetylazanyl)butanedioic acid + RESID-alternate + + + AcAsp + PSI-MOD-label + + + acetylaspartic acid + RESID-alternate + + + MOD_RES N-acetylaspartate + UniProt-feature + + + N-acetyl-L-aspartic acid + RESID-name + + + N-acetylated L-aspartic acid + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 6 H 8 N 1 O 4 + + + + MassAvg + 158.13 + + + + MassMono + 158.045333 + + + + Origin + D + + + + Source + natural + + + + TermSpec + N-term + + MOD:00904 + MOD:01458 + PSI-MOD + + + MOD:00052 + N-acetyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. + + 28939 + ChEBI + + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 1500421 + PubMed + + + 15350136 + PubMed + + + 6725286 + PubMed + + + AA0043 + RESID + + + incidental to RESID:AA0223 + PSI-MOD-slim + + (2R)-2-acetamido-3-sulfanylpropanoic acid + RESID-systematic + + + 2-acetylamino-3-mercaptopropanoic acid + RESID-alternate + + + 2-acetylamino-3-sulfanylpropanoic acid + RESID-alternate + + + 2-acetylazanyl-3-sulfanylpropanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + MOD_RES N-acetylcysteine + UniProt-feature + + + N-acetyl-L-cysteine + RESID-name + + + N-acetylated cysteine + PSI-MOD-alternate + + + N-acetylcysteine + RESID-alternate + + + NAcCys + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 S 0 + + + + DiffMono + 42.010565 + + + + Formula + C 5 H 8 N 1 O 2 S 1 + + + + MassAvg + 146.18 + + + + MassMono + 146.027574 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00646 + MOD:01458 + PSI-MOD + + + MOD:00053 + N-acetyl-L-glutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. + + 17533 + ChEBI + + + 6725286 + PubMed + + + AA0044 + RESID + + + PSI-MOD-slim + + (2S)-2-(acetamido)pentanedioic acid + RESID-systematic + + + 2-(acetylamino)pentanedioic acid + RESID-alternate + + + 2-(acetylazanyl)pentanedioic acid + RESID-alternate + + + acetylglutamic acid + RESID-alternate + + + AcGlu + PSI-MOD-label + + + MOD_RES N-acetylglutamate + UniProt-feature + + + N-acetyl-L-glutamic acid + RESID-name + + + N-acetylated L-glutamic acid + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 7 H 10 N 1 O 4 + + + + MassAvg + 172.16 + + + + MassMono + 172.060983 + + + + Origin + E + + + + Source + natural + + + + TermSpec + N-term + + MOD:00906 + MOD:01458 + PSI-MOD + + + MOD:00054 + N-acetyl-L-glutamine + + A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. + + AA0045 + RESID + + + This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2S)-2-acetamido-5-pentanediamic acid + RESID-systematic + + + 2-acetylamino-5-amino-5-oxopentanoic acid + RESID-alternate + + + 2-acetylamino-5-pentanediamic acid + RESID-alternate + + + 2-acetylazanyl-5-azanyl-5-oxopentanoic acid + RESID-alternate + + + acetylglutamine + RESID-alternate + + + AcGln + PSI-MOD-label + + + N-acetyl-L-glutamine + RESID-name + + + N-acetylated L-glutamine + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 7 H 11 N 2 O 3 + + + + MassAvg + 171.18 + + + + MassMono + 171.076967 + + + + Origin + Q + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00907 + MOD:01458 + PSI-MOD + + + MOD:00055 + N-acetylglycine + + A protein modification that effectively converts a glycine residue to N-acetylglycine. + + 272676 + PubMed + + + 5545094 + PubMed + + + 6754709 + PubMed + + + AA0046 + RESID + + + PSI-MOD-slim + + (acetylamino)acetic acid + RESID-alternate + + + (acetylazanyl)ethanoic acid + RESID-alternate + + + 2-(acetamido)ethanoic acid + RESID-systematic + + + 2-(acetylamino)ethanoic acid + RESID-alternate + + + aceturic acid + RESID-alternate + + + AcGly + PSI-MOD-label + + + MOD_RES N-acetylglycine + UniProt-feature + + + N-acetylated glycine + PSI-MOD-alternate + + + N-acetylglycine + RESID-name + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 4 H 6 N 1 O 2 + + + + MassAvg + 100.10 + + + + MassMono + 100.039853 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00908 + MOD:01458 + PSI-MOD + + + MOD:00056 + N-acetyl-L-isoleucine + + A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. + + 8034631 + PubMed + + + AA0047 + RESID + + + This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2S,3S)-2-acetamido-3-methylpentanoic acid + RESID-systematic + + + 2-acetylamino-3-methylpentanoic acid + RESID-alternate + + + 2-acetylazanyl-3-methylpentanoic acid + RESID-alternate + + + acetylisoleucine + RESID-alternate + + + AcIle + PSI-MOD-label + + + N-acetyl-L-isoleucine + RESID-name + + + N-acetylated L-isoleucine + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 14 N 1 O 2 + + + + MassAvg + 156.20 + + + + MassMono + 156.102454 + + + + Origin + I + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00910 + MOD:01458 + PSI-MOD + + + MOD:00057 + N2-acetyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + AA0048 + RESID + + + This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2S)-2-acetamido-6-aminohexanoic acid + RESID-systematic + + + 2-acetylamino-6-aminohexanoic acid + RESID-alternate + + + 2-acetylazanyl-6-azanylhexanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + N2-acetyl-L-lysine + RESID-name + + + N2-acetylated L-lysine + PSI-MOD-alternate + + + N2-acetyllysine + RESID-alternate + + + N2AcLys + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 15 N 2 O 2 + + + + MassAvg + 171.22 + + + + MassMono + 171.113353 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00723 + MOD:01458 + PSI-MOD + + + MOD:00058 + N-acetyl-L-methionine + + A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. + + 7944406 + PubMed + + + AA0049 + RESID + + + PSI-MOD-slim + + (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-acetylamino-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + 2-acetylamino-4-(methylthio)butanoic acid + RESID-alternate + + + 2-acetylazanyl-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + acetylmethionine + RESID-alternate + + + AcMet + PSI-MOD-label + + + methionamine + RESID-alternate + + + MOD_RES N-acetylmethionine + UniProt-feature + + + N-acetyl-L-methionine + RESID-name + + + N-acetylated L-methionine + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 S 0 + + + + DiffMono + 42.010565 + + + + Formula + C 7 H 12 N 1 O 2 S 1 + + + + MassAvg + 174.24 + + + + MassMono + 174.058875 + + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:00913 + MOD:01458 + PSI-MOD + + + MOD:00059 + N-acetyl-L-proline + + A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. + + 2928307 + PubMed + + + AA0050 + RESID + + + PSI-MOD-slim + + (2S)-1-acetyl-2-pyrrolidinecarboxylic acid + RESID-systematic + + + 1-acetylproline + RESID-alternate + + + acetylproline + RESID-alternate + + + MOD_RES N-acetylproline + UniProt-feature + + + N-acetyl-L-proline + RESID-name + + + N-acetylated L-proline + PSI-MOD-alternate + + + N-acetylproline + RESID-alternate + + + NAcPro + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 7 H 10 N 1 O 2 + + + + MassAvg + 140.16 + + + + MassMono + 140.071154 + + + + Origin + P + + + + Source + natural + + + + TermSpec + N-term + + MOD:00915 + MOD:01458 + PSI-MOD + + + MOD:00060 + N-acetyl-L-serine + + A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + 1880797 + PubMed + + + 2106685 + PubMed + + + 6997045 + PubMed + + + AA0051 + RESID + + + PSI-MOD-slim + + (2S)-2-acetamido-3-hydroxypropanoic acid + RESID-systematic + + + 2-acetylamino-3-hydroxypropanoic acid + RESID-alternate + + + 2-acetylazanyl-3-hydroxypropanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + MOD_RES N-acetylserine + UniProt-feature + + + N-acetyl-L-serine + RESID-name + + + N-acetylated L-serine + PSI-MOD-alternate + + + N-acetylserine + RESID-alternate + + + NAcSer + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 5 H 8 N 1 O 3 + + + + MassAvg + 130.12 + + + + MassMono + 130.050418 + + + + Origin + S + + + + Source + natural + + + + TermSpec + N-term + + MOD:00647 + MOD:01458 + PSI-MOD + + + MOD:00061 + N-acetyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + 2106685 + PubMed + + + 6997045 + PubMed + + + AA0052 + RESID + + + PSI-MOD-slim + + (2S,3R)-2-acetamido-3-hydroxybutanoic acid + RESID-systematic + + + 2-acetylamino-3-hydroxybutanoic acid + RESID-alternate + + + 2-acetylazanyl-3-hydroxybutanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + Acetylation + UniMod-description + + + MOD_RES N-acetylthreonine + UniProt-feature + + + N-acetyl-L-threonine + RESID-name + + + N-acetylated L-threonine + PSI-MOD-alternate + + + N-acetylthreonine + RESID-alternate + + + N-methylcarbonylthreonine + RESID-alternate + + + NAcThr + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 6 H 10 N 1 O 3 + + + + MassAvg + 144.15 + + + + MassMono + 144.066068 + + + + Origin + T + + + + Source + natural + + + + TermSpec + N-term + + MOD:01186 + MOD:01458 + PSI-MOD + + + MOD:00062 + N-acetyl-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + 2506074 + PubMed + + + 475783 + PubMed + + + AA0053 + RESID + + + + (2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid + RESID-systematic + + + 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid + RESID-alternate + + + 2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + AcTyr + PSI-MOD-label + + + MOD_RES N-acetyltyrosine + UniProt-feature + + + N-acetyl-L-tyrosine + RESID-name + + + N-acetylated L-tyrosine + PSI-MOD-alternate + + + N-acetyltyrosine + RESID-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 11 H 12 N 1 O 3 + + + + MassAvg + 206.22 + + + + MassMono + 206.081718 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + N-term + + MOD:00919 + MOD:01458 + PSI-MOD + + + MOD:00063 + N-acetyl-L-valine + + A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. + + 1735421 + PubMed + + + AA0054 + RESID + + + PSI-MOD-slim + + (2S)-2-acetamido-3-methylbutanoic acid + RESID-systematic + + + 2-acetylamino-3-methylbutanoic acid + RESID-alternate + + + 2-acetylazanyl-3-methylbutanoic acid + RESID-alternate + + + AcVal + PSI-MOD-label + + + MOD_RES N-acetylvaline + UniProt-feature + + + N-acetyl-L-valine + RESID-name + + + N-acetylated L-valine + PSI-MOD-alternate + + + N-acetylvaline + RESID-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 7 H 12 N 1 O 2 + + + + MassAvg + 142.18 + + + + MassMono + 142.086804 + + + + Origin + V + + + + Source + natural + + + + TermSpec + N-term + + MOD:00920 + MOD:01458 + PSI-MOD + + + MOD:00064 + N6-acetyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. + + 17752 + ChEBI + + + 214 + DeltaMass + + + 11369851 + PubMed + + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + 1680872 + PubMed + + + 670159 + PubMed + + + AA0055 + RESID + + + 1#K + UniMod + + + PSI-MOD-slim + + (2S)-6-acetamido-2-aminohexanoic acid + RESID-systematic + + + 6-acetylamino-2-aminohexanoic acid + RESID-alternate + + + 6-acetylazanyl-2-aminohexanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + Acetylation + UniMod-description + + + acetylk + OMSSA-label + + + epsilon-acetyllysine + RESID-alternate + + + MOD_RES N6-acetyllysine + UniProt-feature + + + N(zeta)-acetyllysine + RESID-alternate + + + N6-acetyl-L-lysine + RESID-name + + + N6-acetylated L-lysine + PSI-MOD-alternate + + + N6AcLys + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 14 N 2 O 2 + + + + MassAvg + 170.21 + + + + MassMono + 170.105528 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00723 + MOD:01875 + PSI-MOD + + + MOD:00065 + S-acetyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 1310545 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + AA0056 + RESID + + + 1#C + UniMod + + + PSI-MOD-slim + + (2R)-3-acetylsulfanyl-2-aminopropanoic acid + RESID-systematic + + + 2-amino-3-(acetylthio)propanoic acid + RESID-alternate + + + 2-azanyl-3-(acetylsulfanyl)propanoic acid + RESID-alternate + + + Acetyl + PSI-MS-label + + + Acetylation + UniMod-description + + + ACT_SITE S-acetylcysteine intermediate + UniProt-feature + + + cysteine acetate thioester + RESID-alternate + + + S-acetyl-L-cysteine + RESID-name + + + S-acetylcysteine + RESID-alternate + + + SAcCys + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 S 0 + + + + DiffMono + 42.010565 + + + + Formula + C 5 H 7 N 1 O 2 S 1 + + + + MassAvg + 145.18 + + + + MassMono + 145.019749 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00645 + MOD:00646 + PSI-MOD + + + MOD:00066 + N-formylglycine + + A protein modification that effectively converts a glycine residue to N-formylglycine. + + 5139483 + PubMed + + + AA0057 + RESID + + + + (formylamino)acetic acid + RESID-alternate + + + (formylamino)ethanoic acid + RESID-systematic + + + (formylazanyl)ethanoic acid + RESID-alternate + + + 2-formamidoacetic acid + RESID-alternate + + + 2-formamidoethanoic acid + RESID-alternate + + + MOD_RES N-formylglycine + UniProt-feature + + + N(alpha)-formylglycine + RESID-alternate + + + N-formylated glycine + PSI-MOD-alternate + + + N-formylglycine + RESID-name + + + NFoGly + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 3 H 4 N 1 O 2 + + + + MassAvg + 86.07 + + + + MassMono + 86.024203 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00409 + MOD:00908 + MOD:01696 + PSI-MOD + + + MOD:00067 + N-D-glucuronoylglycine + + A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine. + + 10858503 + PubMed + + + 12716131 + PubMed + + + 6493057 + PubMed + + + 7398618 + PubMed + + + AA0058 + RESID + + + + 2-(glucuronoylamino)ethanoic acid + RESID-systematic + + + Glucuronyl + PSI-MS-label + + + MOD_RES N-D-glucuronoyl glycine + UniProt-feature + + + N-D-glucuronoyl-glycine + RESID-name + + + N-D-glucuronyl-glycine + RESID-alternate + + + NGlcAGly + PSI-MOD-label + + + ntermpepglucuronylg + OMSSA-label + + + + DiffAvg + 176.12 + + + + DiffFormula + C 6 H 8 N 0 O 6 + + + + DiffMono + 176.032088 + + + + Formula + C 8 H 12 N 1 O 7 + + + + MassAvg + 234.18 + + + + MassMono + 234.061377 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00447 + MOD:00908 + PSI-MOD + + + MOD:00068 + N-myristoylglycine + + A protein modification that effectively converts a glycine residue to N-myristoylglycine. + + 11955007 + PubMed + + + 11955008 + PubMed + + + 1326520 + PubMed + + + 1386601 + PubMed + + + 6436247 + PubMed + + + 7543369 + PubMed + + + AA0059 + RESID + + + 45#G + UniMod + + + PSI-MOD-slim + + (tetradecanoylamino)ethanoic acid + RESID-systematic + + + LIPID N-myristoyl glycine + UniProt-feature + + + Myristoyl + PSI-MS-label + + + Myristoylation + UniMod-description + + + N-(1-oxotetradecyl)glycine + RESID-alternate + + + N-(C14:0 aliphatic acyl)glycine + PSI-MOD-alternate + + + N-myristoyl-glycine + RESID-name + + + N-myristoylated glycine + PSI-MOD-alternate + + + N-myristylglycine + RESID-alternate + + + N-tetradecanoylglycine + RESID-alternate + + + NMyrGly + PSI-MOD-label + + + ntermpepmyristoylationg + OMSSA-label + + + + DiffAvg + 210.36 + + + + DiffFormula + C 14 H 26 N 0 O 1 + + + + DiffMono + 210.198365 + + + + Formula + C 16 H 30 N 1 O 2 + + + + MassAvg + 268.42 + + + + MassMono + 268.227654 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00650 + MOD:00908 + MOD:01696 + PSI-MOD + + + MOD:00069 + N-palmitoyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. + + 10896212 + PubMed + + + 4575979 + PubMed + + + 9056182 + PubMed + + + 9593755 + PubMed + + + AA0060 + RESID + + + incidental to RESID:AA0107 incidental to RESID:AA0309 + PSI-MOD-slim + + (2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid + RESID-systematic + + + 2-hexadecanamido-3-sulfanylpropanoic acid + RESID-alternate + + + 2-hexadecanoylamino-3-mercaptopropanoic acid + RESID-alternate + + + LIPID N-palmitoyl cysteine + UniProt-feature + + + N-(1-oxahexadecyl)-L-cysteine + RESID-alternate + + + N-palmitoyl-L-cysteine + RESID-name + + + N-palmitoylated L-cysteine + PSI-MOD-alternate + + + NPamCys + PSI-MOD-label + + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + C 19 H 36 N 1 O 2 S 1 + + + + MassAvg + 342.56 + + + + MassMono + 342.246675 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:01684 + MOD:01685 + PSI-MOD + + + MOD:00070 + N-methyl-L-alanine + + A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. + + 17519 + ChEBI + + + 323502 + PubMed + + + 337304 + PubMed + + + 7007074 + PubMed + + + AA0061 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + PSI-MOD-slim + + (2S)-2-methylaminopropanoic acid + RESID-systematic + + + 2-methylazanylpropanoic acid + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N-methylalanine + UniProt-feature + + + N-methyl-L-alanine + RESID-name + + + N-methylalanine + RESID-alternate + + + N-methylated L-alanine + PSI-MOD-alternate + + + NMe1Ala + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 4 H 7 N 1 O 1 + + + + MassAvg + 85.11 + + + + MassMono + 85.052764 + + + + Origin + A + + + + Source + natural + + + + TermSpec + none + + MOD:01461 + MOD:01680 + PSI-MOD + + + MOD:00071 + N,N,N-trimethyl-L-alanine + + A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. + + 12590383 + PubMed + + + 332162 + PubMed + + + 3979397 + PubMed + + + 6778808 + PubMed + + + 7715456 + PubMed + + + AA0062 + RESID + + + PSI-MOD-slim + + (1S)-1-carboxy-N,N,N-trimethylethanaminium + RESID-systematic + + + (1S)-1-carboxy-N,N,N-trimethylethanazanium + RESID-alternate + + + (2S)-2-(trimethylammonio)propanoic acid + RESID-alternate + + + MOD_RES N,N,N-trimethylalanine + UniProt-feature + + + N,N,N-trimethyl-L-alanine + RESID-name + + + N,N,N-trimethylalanine cation + RESID-alternate + + + N,N,N-trimethylalaninium + RESID-alternate + + + N,N,N-trimethylated L-alanine + PSI-MOD-alternate + + + N2Me3+Ala + PSI-MOD-label + + + NMe3Ala + PSI-MOD-label + + + tri-Methylation + UniMod-description + + + Trimethyl + PSI-MS-label + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 + + + + DiffMono + 43.054227 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 13 N 1 O 1 + + + + MassAvg + 115.18 + + + + MassMono + 115.099165 + + + + Origin + A + + + + Source + natural + + + + TermSpec + N-term + + MOD:01461 + MOD:01698 + PSI-MOD + + + MOD:00072 + N-methylglycine + + A protein modification that effectively converts a glycine residue to N-methylglycine. + + 15611 + ChEBI + + + 0 + DeltaMass + + + 1593629 + PubMed + + + AA0063 + RESID + + + DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + + L-sarcosine + RESID-alternate + + + Methyl + PSI-MS-label + + + methylaminoacetic acid + RESID-alternate + + + methylaminoethanoic acid + RESID-systematic + + + Methylation + UniMod-description + + + N-methylated glycine + PSI-MOD-alternate + + + N-methylglycine + RESID-name + + + NMe1Gly + PSI-MOD-label + + + Sar + DeltaMass-label + + + Sarcosine + DeltaMass-label + + + Sarcosyl + DeltaMass-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + G + + + + Source + natural + + + + TermSpec + none + + MOD:00570 + MOD:00714 + MOD:01680 + PSI-MOD + + + MOD:00073 + N-methyl-L-methionine + + A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. + + 169 + DeltaMass + + + 323502 + PubMed + + + 3298225 + PubMed + + + AA0064 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + PSI-MOD-slim + + (2S)-2-methylamino-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-methylamino-4-(methylthio)butanoic acid + RESID-alternate + + + Methyl + PSI-MS-label + + + Methyl Methionyl + DeltaMass-label + + + Methylation + UniMod-description + + + MOD_RES N-methylmethionine + UniProt-feature + + + N-methyl-L-methionine + RESID-name + + + N-methylated L-methionine + PSI-MOD-alternate + + + N-methylmethionine + RESID-alternate + + + NMe1Met + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 11 N 1 O 1 S 1 + + + + MassAvg + 145.22 + + + + MassMono + 145.056135 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:01463 + MOD:01680 + PSI-MOD + + + MOD:00074 + N-methyl-L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. + + 2577730 + PubMed + + + 413571 + PubMed + + + AA0065 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + PSI-MOD-slim + + (2S)-2-methylamino-3-phenylpropanoic acid + RESID-systematic + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N-methylphenylalanine + UniProt-feature + + + N-methyl-L-phenylalanine + RESID-name + + + N-methylated L-phenylalanine + PSI-MOD-alternate + + + N-methylphenylalanine + RESID-alternate + + + NMe1Phe + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 10 H 11 N 1 O 1 + + + + MassAvg + 161.20 + + + + MassMono + 161.084064 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:01063 + MOD:01680 + PSI-MOD + + + MOD:00075 + N,N-dimethyl-L-proline + + A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. + + 21451 + ChEBI + + + 12964758 + PubMed + + + 14570711 + PubMed + + + 193025 + PubMed + + + 3882426 + PubMed + + + 6254758 + PubMed + + + AA0066 + RESID + + + 529 + UniMod + + + UniMod terminal specification corrected [JSG]. + PSI-MOD-slim + + (2S)-2-carboxy-1,1-dimethylpyrrolidinium + RESID-systematic + + + 1,1-dimethyl-L-prolinium + RESID-alternate + + + Delta:H(5)C(2) + UniMod-interim + + + Dimethyl + PSI-MS-label + + + Dimethylation of proline residue + UniMod-description + + + MOD_RES N,N-dimethylproline + UniProt-feature + + + N,N-dimethyl-L-proline + RESID-name + + + N,N-dimethyl-L-prolinium + RESID-alternate + + + N,N-dimethylated L-proline + PSI-MOD-alternate + + + NMe2Pro + PSI-MOD-label + + + stachydrin + RESID-alternate + + + + DiffAvg + 29.06 + + + + DiffFormula + C 2 H 5 N 0 O 0 + + + + DiffMono + 29.038577 + + + + FormalCharge + 1+ + + + + Formula + C 7 H 13 N 1 O 1 + + + + MassAvg + 127.19 + + + + MassMono + 127.099165 + + + + Origin + P + + + + Source + natural + + + + TermSpec + N-term + + MOD:00710 + MOD:01462 + PSI-MOD + + + MOD:00076 + symmetric dimethyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine. + + 12964758 + PubMed + + + 14570711 + PubMed + + + 15835918 + PubMed + + + 2426402 + PubMed + + + 5128665 + PubMed + + + AA0067 + RESID + + + 36#R + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid + RESID-systematic + + + di-Methylation + UniMod-description + + + Dimethyl + PSI-MS-label + + + MOD_RES Omega-N-methylated arginine + UniProt-feature + + + MOD_RES Symmetric dimethylarginine + UniProt-feature + + + N3,N4-dimethylarginine + RESID-alternate + + + N5-[(methylamino)(methylimino)methyl]ornithine + RESID-alternate + + + NG,N'G-dimethylarginine + RESID-alternate + + + NoNo'Me2Arg + PSI-MOD-label + + + omega-N,omega-N'-dimethyl-L-arginine + RESID-name + + + omega-N,omega-N'-dimethylated L-arginine + PSI-MOD-alternate + + + symmetric dimethylarginine + RESID-alternate + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 4 O 1 + + + + MassAvg + 184.24 + + + + MassMono + 184.132411 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00602 + MOD:00783 + PSI-MOD + + + MOD:00077 + asymmetric dimethyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine. + + 17929 + ChEBI + + + 11152131 + PubMed + + + 12964758 + PubMed + + + 14570711 + PubMed + + + 15835918 + PubMed + + + 3032834 + PubMed + + + AA0068 + RESID + + + 36#R + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid + RESID-systematic + + + asymmetric dimethylarginine + RESID-alternate + + + di-Methylation + UniMod-description + + + Dimethyl + PSI-MS-label + + + MOD_RES Asymmetric dimethylarginine + UniProt-feature + + + MOD_RES Omega-N-methylated arginine + UniProt-feature + + + N5-[(dimethylamino)(imino)methyl]ornithine + RESID-alternate + + + NG,NG-dimethylarginine + RESID-alternate + + + NoNoMe2Arg + PSI-MOD-label + + + omega-N,omega-N-dimethlyated L-arginine + PSI-MOD-alternate + + + omega-N,omega-N-dimethyl-L-arginine + RESID-name + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 4 O 1 + + + + MassAvg + 184.24 + + + + MassMono + 184.132411 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00602 + MOD:00783 + PSI-MOD + + + MOD:00078 + omega-N-methyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. + + 11875433 + PubMed + + + 15835918 + PubMed + + + 2426402 + PubMed + + + 5128665 + PubMed + + + AA0069 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid + RESID-systematic + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES Omega-N-methylarginine + UniProt-feature + + + MOD_RES Omega-N-methylated arginine + UniProt-feature + + + NG-methylarginine + RESID-alternate + + + NoMeArg + PSI-MOD-label + + + omega-N-methyl-L-arginine + RESID-name + + + omega-N-methylated L-arginine + PSI-MOD-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 14 N 4 O 1 + + + + MassAvg + 170.22 + + + + MassMono + 170.116761 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00414 + MOD:00602 + PSI-MOD + + + MOD:00079 + N4-methyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. + + 11875433 + PubMed + + + 2356973 + PubMed + + + 3782095 + PubMed + + + AA0070 + RESID + + + 34#N + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-N4-methylbutanediamic acid + RESID-systematic + + + beta-aspartyl methylamide + RESID-alternate + + + beta-methylasparagine + RESID-misnomer + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + methyln + OMSSA-label + + + MOD_RES N4-methylasparagine + UniProt-feature + + + N(gamma)-methylasparagine + RESID-alternate + + + N-methylasparagine + RESID-alternate + + + N4-methyl-L-asparagine + RESID-name + + + N4-methylated L-asparagine + PSI-MOD-alternate + + + N4Me1Asn + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 5 H 8 N 2 O 2 + + + + MassAvg + 128.13 + + + + MassMono + 128.058578 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00599 + MOD:00602 + MOD:00673 + MOD:00894 + PSI-MOD + + + MOD:00080 + N5-methyl-L-glutamine + + A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. + + 17592 + ChEBI + + + 166 + DeltaMass + + + 11118225 + PubMed + + + 11875433 + PubMed + + + 365579 + PubMed + + + AA0071 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-5-methylamino-5-oxopentanoic acid + RESID-systematic + + + 2-amino-N5-methylpentanediamic acid + RESID-alternate + + + gamma-methylglutamine + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N5-methylglutamine + UniProt-feature + + + N(delta)-methylglutamine + RESID-alternate + + + N-methylglutamine + RESID-alternate + + + N5-methyl-L-glutamine + RESID-name + + + N5-methylated L-glutamine + PSI-MOD-alternate + + + N5Me1Gln + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 10 N 2 O 2 + + + + MassAvg + 142.16 + + + + MassMono + 142.074228 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00602 + MOD:00722 + PSI-MOD + + + MOD:00081 + L-glutamic acid 5-methyl ester (Glu) + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. + + 167 + DeltaMass + + + 16888 + PubMed + + + 6300110 + PubMed + + + AA0072#GLU + RESID + + + 34#E + UniMod + + + DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG]. + PSI-MOD-slim + + (2S)-2-amino-5-methoxy-5-oxopentanoic acid + RESID-systematic + + + (5)-methyl L-hydrogen glutamate + RESID-alternate + + + 2-aminopentanedioic acid 5-methyl ester + RESID-alternate + + + 5-methyl esterified L-glutamic acid + PSI-MOD-alternate + + + 5-methyl L-2-aminoglutarate + RESID-alternate + + + 5-methyl L-glutamate + RESID-alternate + + + glutamic acid 5-methyl ester + RESID-alternate + + + glutamic acid gamma-methyl ester + RESID-alternate + + + L-glutamic acid 5-methyl ester + RESID-name + + + meestere + OMSSA-label + + + Methyl + PSI-MS-label + + + methyl ester + UniMod-alternate + + + Methylation + UniMod-description + + + methyle + OMSSA-label + + + MOD_RES Glutamate methyl ester (Glu) + UniProt-feature + + + O-methyl Glutamyl + DeltaMass-label + + + O5MeGlu + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 9 N 1 O 3 + + + + MassAvg + 143.14 + + + + MassMono + 143.058243 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:01453 + PSI-MOD + + + MOD:00082 + 3'-methyl-L-histidine + + A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine). + + 10660523 + PubMed + + + 11875433 + PubMed + + + 3467365 + PubMed + + + 6692818 + PubMed + + + 8076 + PubMed + + + 8645219 + PubMed + + + AA0073 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid + RESID-systematic + + + 1-methylhistidine + RESID-misnomer + + + 3'-methyl-L-histidine + RESID-name + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES Pros-methylhistidine + UniProt-feature + + + N(delta)-methylhistidine + RESID-alternate + + + N(pi)-methylhistidine + RESID-alternate + + + NpMeHis + PSI-MOD-label + + + pros-methylated L-histidine + PSI-MOD-alternate + + + pros-methylhistidine + RESID-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 9 N 3 O 1 + + + + MassAvg + 151.17 + + + + MassMono + 151.074562 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00724 + PSI-MOD + + + MOD:00083 + N6,N6,N6-trimethyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. + + 17311 + ChEBI + + + 12590383 + PubMed + + + 3145979 + PubMed + + + 4304194 + PubMed + + + 6778808 + PubMed + + + 7093227 + PubMed + + + 8453381 + PubMed + + + AA0074 + RESID + + + DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855 + PSI-MOD-slim + + (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium + RESID-systematic + + + 2-amino-6-(trimethylammonio)hexanoic acid + RESID-alternate + + + 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium + RESID-alternate + + + epsilon-trimethyllysine + RESID-alternate + + + MOD_RES N6,N6,N6-trimethyllysine + UniProt-feature + + + N(zeta)-trimethyllysine + RESID-alternate + + + N-trimethylation (of lysine) + DeltaMass-label + + + N6,N6,N6-trimethyl-L-lysine + RESID-name + + + N6,N6,N6-trimethylated L-lysine + PSI-MOD-alternate + + + N6,N6,N6-trimethyllysin-N6-ium + RESID-alternate + + + N6,N6,N6-trimethyllysine cation + RESID-alternate + + + N6Me3+Lys + PSI-MOD-label + + + tri-Methylation + UniMod-description + + + Trimethyl + PSI-MS-label + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 + + + + DiffMono + 43.054227 + + + + FormalCharge + 1+ + + + + Formula + C 9 H 19 N 2 O 1 + + + + MassAvg + 171.26 + + + + MassMono + 171.149190 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00602 + MOD:00663 + MOD:00711 + PSI-MOD + + + MOD:00084 + N6,N6-dimethyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. + + 10550045 + PubMed + + + 12964758 + PubMed + + + 14570711 + PubMed + + + 3100523 + PubMed + + + 8453381 + PubMed + + + AA0075 + RESID + + + 36#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(dimethylamino)hexanoic acid + RESID-systematic + + + di-Methylation + UniMod-description + + + Dimethyl + PSI-MS-label + + + dimethylk + OMSSA-label + + + epsilon-dimethyllysine + RESID-alternate + + + lysine derivative Lys(y) + RESID-alternate + + + MOD_RES N6,N6-dimethyllysine + UniProt-feature + + + N(zeta)-dimethyllysine + RESID-alternate + + + N6,N6-dimethyl-L-lysine + RESID-name + + + N6,N6-dimethylated L-lysine + PSI-MOD-alternate + + + N6Me2Lys + PSI-MOD-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 2 O 1 + + + + MassAvg + 156.23 + + + + MassMono + 156.126263 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00429 + MOD:00602 + MOD:00663 + PSI-MOD + + + MOD:00085 + N6-methyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. + + 17604 + ChEBI + + + 165 + DeltaMass + + + 11875433 + PubMed + + + 3926756 + PubMed + + + AA0076 + RESID + + + 34#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-methylaminohexanoic acid + RESID-systematic + + + epsilon-methyllysine + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N6-methyllysine + UniProt-feature + + + N(zeta)-methyllysine + RESID-alternate + + + N-methyl Lysyl + DeltaMass-label + + + N6-methyl-L-lysine + RESID-name + + + N6-methylated L-lysine + PSI-MOD-alternate + + + N6Me1Lys + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 14 N 2 O 1 + + + + MassAvg + 142.20 + + + + MassMono + 142.110613 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00602 + MOD:01683 + PSI-MOD + + + MOD:00086 + N6-palmitoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. + + 2498336 + PubMed + + + 7801126 + PubMed + + + 7939682 + PubMed + + + AA0077 + RESID + + + 47#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(hexadecanoylamino)hexanoic acid + RESID-systematic + + + 2-amino-6-(hexadecanamido)hexanoic acid + RESID-alternate + + + epsilon-palmitoyllysine + RESID-alternate + + + LIPID N6-palmitoyl lysine + UniProt-feature + + + N(zeta)-palmitoyllysine + RESID-alternate + + + N6-(1-oxohexadecyl)-L-lysine + RESID-alternate + + + N6-palmitoyl-L-lysine + RESID-name + + + N6-palmitoylated L-lysine + PSI-MOD-alternate + + + N6PamLys + PSI-MOD-label + + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + palmitoylationk + OMSSA-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 + + + + DiffMono + 238.229666 + + + + Formula + C 22 H 42 N 2 O 2 + + + + MassAvg + 366.59 + + + + MassMono + 366.324629 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00651 + MOD:01875 + PSI-MOD + + + MOD:00087 + N6-myristoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. + + 1402651 + PubMed + + + 8346241 + PubMed + + + AA0078 + RESID + + + 45#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(tetradecanoylamino)hexanoic acid + RESID-systematic + + + 2-amino-6-(tetradecanamido)hexanoic acid + RESID-alternate + + + epsilon-myristoyllysine + RESID-alternate + + + LIPID N6-myristoyl lysine + UniProt-feature + + + Myristoyl + PSI-MS-label + + + Myristoylation + UniMod-description + + + myristoylationk + OMSSA-label + + + N(zeta)-myristoyllysine + RESID-alternate + + + N6-(1-oxotetradecyl)-L-lysine + RESID-alternate + + + N6-(C14:0 aliphatic acyl)lysine + PSI-MOD-alternate + + + N6-myristoyl-L-lysine + RESID-name + + + N6-myristoylated L-lysine + PSI-MOD-alternate + + + N6MyrLys + PSI-MOD-label + + + + DiffAvg + 210.36 + + + + DiffFormula + C 14 H 26 N 0 O 1 + + + + DiffMono + 210.198365 + + + + Formula + C 20 H 38 N 2 O 2 + + + + MassAvg + 338.54 + + + + MassMono + 338.293328 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00650 + MOD:01875 + PSI-MOD + + + MOD:00088 + O-palmitoyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. + + 6642431 + PubMed + + + 8413602 + PubMed + + + AA0079 + RESID + + + 47#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid + RESID-systematic + + + L-threonine hexadecanoate ester + RESID-alternate + + + LIPID O-palmitoyl threonine + UniProt-feature + + + O-palmitoyl-L-threonine + RESID-name + + + O-palmitoylated L-threonine + PSI-MOD-alternate + + + O3-palmitoyl-threonine + RESID-alternate + + + OPamThr + PSI-MOD-label + + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + palmitoylationt + OMSSA-label + + + threonine palmitate ester + RESID-alternate + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 + + + + DiffMono + 238.229666 + + + + Formula + C 20 H 37 N 1 O 3 + + + + MassAvg + 339.52 + + + + MassMono + 339.277344 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00652 + MOD:00917 + PSI-MOD + + + MOD:00089 + O-palmitoyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. + + 3467339 + PubMed + + + AA0080 + RESID + + + 47#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(hexadecanoyloxy)propanoic acid + RESID-systematic + + + ACT_SITE O-palmitoyl serine intermediate + UniProt-feature + + + L-serine hexadecanoate ester + RESID-alternate + + + LIPID O-palmitoyl serine + UniProt-feature + + + O-palmitoyl-L-serine + RESID-name + + + O-palmitoylated L-serine + PSI-MOD-alternate + + + O3-palmitoyl-serine + RESID-alternate + + + OPamSer + PSI-MOD-label + + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + palmitoylations + OMSSA-label + + + serine palmitate ester + RESID-alternate + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 + + + + DiffMono + 238.229666 + + + + Formula + C 19 H 35 N 1 O 3 + + + + MassAvg + 325.49 + + + + MassMono + 325.261694 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00652 + MOD:00916 + PSI-MOD + + + MOD:00090 + L-alanine amide + + A protein modification that effectively converts an L-alanine residue to L-alanine amide. + + 1377792 + PubMed + + + 2069951 + PubMed + + + 8472537 + PubMed + + + 952951 + PubMed + + + AA0081 + RESID + + + PSI-MOD-slim + + (2S)-2-aminopropanamide + RESID-systematic + + + AlaN + PSI-MOD-label + + + alaninamide + RESID-alternate + + + amidated L-alanine + PSI-MOD-alternate + + + L-alanine amide + RESID-name + + + MOD_RES Alanine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 3 H 7 N 2 O 1 + + + + MassAvg + 87.10 + + + + MassMono + 87.055838 + + + + Origin + A + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00901 + PSI-MOD + + + MOD:00091 + L-arginine amide + + A protein modification that effectively converts an L-arginine residue to L-arginine amide. + + 2229025 + PubMed + + + 2753890 + PubMed + + + 743209 + PubMed + + + AA0082 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide + RESID-systematic + + + 2-amino-5-carbamimidamidopentanamide + RESID-alternate + + + 2-amino-5-guanidinopentanamide + RESID-alternate + + + amidated L-arginine + PSI-MOD-alternate + + + argininamide + RESID-alternate + + + ArgN + PSI-MOD-label + + + L-arginine amide + RESID-name + + + MOD_RES Arginine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 6 H 14 N 5 O 1 + + + + MassAvg + 172.21 + + + + MassMono + 172.119835 + + + + Origin + R + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00902 + PSI-MOD + + + MOD:00092 + L-asparagine amide + + A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. + + 2753132 + PubMed + + + 279902 + PubMed + + + 3415690 + PubMed + + + AA0083 + RESID + + + PSI-MOD-slim + + (2S)-2-aminobutanediamide + RESID-systematic + + + amidated L-asparagine + PSI-MOD-alternate + + + AsnN + PSI-MOD-label + + + asparaginamide + RESID-alternate + + + L-asparagine amide + RESID-name + + + MOD_RES Asparagine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 4 H 8 N 3 O 2 + + + + MassAvg + 130.13 + + + + MassMono + 130.061652 + + + + Origin + N + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00903 + PSI-MOD + + + MOD:00093 + L-aspartic acid 1-amide + + A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. + + 2542051 + PubMed + + + AA0084 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-1-butanediamic acid + RESID-systematic + + + 1-amidated L-aspartic acid + PSI-MOD-alternate + + + 3,4-diamino-4-oxobutanoic acid + RESID-alternate + + + 3-amino-succinamic acid + RESID-alternate + + + alpha-asparagine + RESID-alternate + + + AspN + PSI-MOD-label + + + isoasparagine + RESID-alternate + + + L-aspartic acid 1-amide + RESID-name + + + MOD_RES Aspartic acid 1-amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 4 H 7 N 2 O 3 + + + + MassAvg + 131.11 + + + + MassMono + 131.045667 + + + + Origin + D + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00904 + PSI-MOD + + + MOD:00094 + L-cysteine amide + + A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. + + 1892838 + PubMed + + + 7149738 + PubMed + + + AA0085 + RESID + + + PSI-MOD-slim + + (2R)-2-amino-3-sulfanylpropanamide + RESID-systematic + + + 2-amino-3-mercaptopropanamide + RESID-alternate + + + amidated L-cysteine + PSI-MOD-alternate + + + CysN + PSI-MOD-label + + + cysteinamide + RESID-alternate + + + L-cysteine amide + RESID-name + + + MOD_RES Cysteine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 S 0 + + + + DiffMono + -0.984016 + + + + Formula + C 3 H 7 N 2 O 1 S 1 + + + + MassAvg + 119.16 + + + + MassMono + 119.027909 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00905 + PSI-MOD + + + MOD:00095 + L-glutamine amide + + A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. + + 7673220 + PubMed + + + 9048550 + PubMed + + + AA0086 + RESID + + + PSI-MOD-slim + + (2S)-2-aminopentanediamide + RESID-systematic + + + amidated L-glutamine + PSI-MOD-alternate + + + GlnN + PSI-MOD-label + + + glutaminamide + RESID-alternate + + + L-glutamine amide + RESID-name + + + MOD_RES Glutamine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 5 H 10 N 3 O 2 + + + + MassAvg + 144.15 + + + + MassMono + 144.077302 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00907 + PSI-MOD + + + MOD:00096 + L-glutamic acid 1-amide + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. + + 1093875 + PubMed + + + 14550575 + PubMed + + + AA0087 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-1-pentanediamic acid + RESID-systematic + + + 1-amidated L-glutamic acid + PSI-MOD-alternate + + + 4,5-diamino-5-oxopentanoic acid + RESID-alternate + + + GluN + PSI-MOD-label + + + isoglutamine + RESID-alternate + + + L-glutamic acid 1-amide + RESID-name + + + MOD_RES Glutamic acid 1-amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 5 H 9 N 2 O 3 + + + + MassAvg + 145.14 + + + + MassMono + 145.061317 + + + + Origin + E + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00906 + PSI-MOD + + + MOD:00097 + glycine amide + + A protein modification that effectively converts a glycine residue to glycine amide. + + 13591312 + PubMed + + + AA0088 + RESID + + + PSI-MOD-slim + + 2-aminoacetamide + RESID-alternate + + + 2-aminoethanamide + RESID-systematic + + + 2-azanylethanamide + RESID-alternate + + + amidated glycine + PSI-MOD-alternate + + + glycinamide + RESID-alternate + + + glycine amide + RESID-name + + + GlyN + PSI-MOD-label + + + MOD_RES Glycine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 2 H 5 N 2 O 1 + + + + MassAvg + 73.07 + + + + MassMono + 73.040188 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00908 + PSI-MOD + + + MOD:00098 + L-histidine amide + + A protein modification that effectively converts an L-histidine residue to L-histidine amide. + + 2153586 + PubMed + + + 2307683 + PubMed + + + 2839478 + PubMed + + + AA0089 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(1H-imidazol-4-yl)propanamide + RESID-systematic + + + amidated L-histidine + PSI-MOD-alternate + + + HisN + PSI-MOD-label + + + histidinamide + RESID-alternate + + + L-histidine amide + RESID-name + + + MOD_RES Histidine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 6 H 9 N 4 O 1 + + + + MassAvg + 153.16 + + + + MassMono + 153.077636 + + + + Origin + H + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00909 + PSI-MOD + + + MOD:00099 + L-isoleucine amide + + A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. + + AA0090 + RESID + + + PSI-MOD-slim + + (2S,3S)-2-amino-3-methylpentanamide + RESID-systematic + + + amidated L-isoleucine + PSI-MOD-alternate + + + IleN + PSI-MOD-label + + + isoleucinamide + RESID-alternate + + + L-isoleucine amide + RESID-name + + + MOD_RES Isoleucine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 6 H 13 N 2 O 1 + + + + MassAvg + 129.18 + + + + MassMono + 129.102788 + + + + Origin + I + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00910 + PSI-MOD + + + MOD:00100 + L-leucine amide + + A protein modification that effectively converts an L-leucine residue to L-leucine amide. + + 2578459 + PubMed + + + AA0091 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-4-methylpentanamide + RESID-systematic + + + 2-amino-4-methylvaleramide + RESID-alternate + + + 2-azanyl-4-methylpentanamide + RESID-alternate + + + alpha-aminoisocaproamide + RESID-alternate + + + amidated L-leucine + PSI-MOD-alternate + + + L-leucine amide + RESID-name + + + leucinamide + RESID-alternate + + + LeuN + PSI-MOD-label + + + MOD_RES Leucine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 6 H 13 N 2 O 1 + + + + MassAvg + 129.18 + + + + MassMono + 129.102788 + + + + Origin + L + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00911 + PSI-MOD + + + MOD:00101 + L-lysine amide + + A protein modification that effectively converts an L-lysine residue to L-lysine amide. + + 6579533 + PubMed + + + AA0092 + RESID + + + PSI-MOD-slim + + (2S)-2,6-diaminohexanamide + RESID-systematic + + + amidated L-lysine + PSI-MOD-alternate + + + L-lysine amide + RESID-name + + + lysinamide + RESID-alternate + + + LysN + PSI-MOD-label + + + MOD_RES Lysine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 6 H 14 N 3 O 1 + + + + MassAvg + 144.20 + + + + MassMono + 144.113687 + + + + Origin + K + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00912 + PSI-MOD + + + MOD:00102 + L-methionine amide + + A protein modification that effectively converts an L-methionine residue to L-methionine amide. + + 4375977 + PubMed + + + AA0093 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-4-(methylsulfanyl)butanamide + RESID-systematic + + + 2-amino-4-(methylthio)butanamide + RESID-alternate + + + amidated L-methionine + PSI-MOD-alternate + + + L-methionine amide + RESID-name + + + methioninamide + RESID-alternate + + + MetN + PSI-MOD-label + + + MOD_RES Methionine amide + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 S 0 + + + + DiffMono + -0.984016 + + + + Formula + C 5 H 11 N 2 O 1 S 1 + + + + MassAvg + 147.22 + + + + MassMono + 147.059209 + + + + Origin + M + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00913 + PSI-MOD + + + MOD:00103 + L-phenylalanine amide + + A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. + + 2905621 + PubMed + + + 8868490 + PubMed + + + AA0094 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-phenylpropanamide + RESID-systematic + + + amidated L-phenylalanine + PSI-MOD-alternate + + + L-phenylalanine amide + RESID-name + + + MOD_RES Phenylalanine amide + UniProt-feature + + + PheN + PSI-MOD-label + + + phenylalaninamide + RESID-alternate + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 9 H 11 N 2 O 1 + + + + MassAvg + 163.20 + + + + MassMono + 163.087138 + + + + Origin + F + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00914 + PSI-MOD + + + MOD:00104 + L-proline amide + + A protein modification that effectively converts an L-proline residue to L-proline amide. + + 4982117 + PubMed + + + 5760861 + PubMed + + + AA0095 + RESID + + + PSI-MOD-slim + + (2S)-pyrrolidine-2-carboxamide + RESID-systematic + + + amidated L-proline + PSI-MOD-alternate + + + L-proline amide + RESID-name + + + MOD_RES Proline amide + UniProt-feature + + + prolinamide + RESID-alternate + + + ProN + PSI-MOD-label + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 5 H 9 N 2 O 1 + + + + MassAvg + 113.14 + + + + MassMono + 113.071488 + + + + Origin + P + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00915 + PSI-MOD + + + MOD:00105 + L-serine amide + + A protein modification that effectively converts an L-serine residue to L-serine amide. + + 743209 + PubMed + + + AA0096 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-hydroxypropanamide + RESID-systematic + + + amidated L-serine + PSI-MOD-alternate + + + L-serine amide + RESID-name + + + MOD_RES Serine amide + UniProt-feature + + + serinamide + RESID-alternate + + + SerN + PSI-MOD-label + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 3 H 7 N 2 O 2 + + + + MassAvg + 103.10 + + + + MassMono + 103.050752 + + + + Origin + S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00916 + PSI-MOD + + + MOD:00106 + L-threonine amide + + A protein modification that effectively converts an L-threonine residue to L-threonine amide. + + 1390774 + PubMed + + + AA0097 + RESID + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-hydroxybutanamide + RESID-systematic + + + amidated L-threonine + PSI-MOD-alternate + + + L-threonine amide + RESID-name + + + MOD_RES Threonine amide + UniProt-feature + + + threoninamide + RESID-alternate + + + ThrN + PSI-MOD-label + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 4 H 9 N 2 O 2 + + + + MassAvg + 117.13 + + + + MassMono + 117.066403 + + + + Origin + T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00917 + PSI-MOD + + + MOD:00107 + L-tryptophan amide + + A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. + + 3947348 + PubMed + + + AA0098 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(1H-indol-3-yl)propanamide + RESID-systematic + + + amidated L-tryptophan + PSI-MOD-alternate + + + L-tryptophan amide + RESID-name + + + MOD_RES Tryptophan amide + UniProt-feature + + + TrpN + PSI-MOD-label + + + tryptophanamide + RESID-alternate + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 11 H 12 N 3 O 1 + + + + MassAvg + 202.24 + + + + MassMono + 202.098037 + + + + Origin + W + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00918 + PSI-MOD + + + MOD:00108 + L-tyrosine amide + + A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. + + 1377792 + PubMed + + + 3562898 + PubMed + + + 6509012 + PubMed + + + AA0099 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(4-hydoxyphenyl)propanamide + RESID-systematic + + + amidated L-tyrosine + PSI-MOD-alternate + + + L-tyrosine amide + RESID-name + + + MOD_RES Tyrosine amide + UniProt-feature + + + TyrN + PSI-MOD-label + + + tyrosinamide + RESID-alternate + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 9 H 11 N 2 O 2 + + + + MassAvg + 179.20 + + + + MassMono + 179.082053 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00919 + PSI-MOD + + + MOD:00109 + L-valine amide + + A protein modification that effectively converts an L-valine residue to L-valine amide. + + 2578459 + PubMed + + + 5465996 + PubMed + + + AA0100 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-methylbutanamide + RESID-systematic + + + L-valine amide + RESID-name + + + MOD_RES Valine amide + UniProt-feature + + + valinamide + RESID-alternate + + + ValN + PSI-MOD-label + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 5 H 11 N 2 O 1 + + + + MassAvg + 115.16 + + + + MassMono + 115.087138 + + + + Origin + V + + + + Source + natural + + + + TermSpec + C-term + + MOD:00883 + MOD:00920 + PSI-MOD + + + MOD:00110 + L-cysteine methyl disulfide + + A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide. + + 10555576 + PubMed + + + 163643 + PubMed + + + 2056535 + PubMed + + + 6381494 + PubMed + + + AA0101 + RESID + + + 39#C + UniMod + + + Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG]. + + (2R)-2-amino-3-(methyldisulfanediyl)propanoic acid + RESID-systematic + + + 2-amino-3-(methyldisulfanediyl)propanoic acid + RESID-alternate + + + 2-amino-3-(methyldithio)propanoic acid + RESID-alternate + + + 2-amino-3-methyldisulfanylpropanoic acid + RESID-alternate + + + 2-azanyl-3-(methyldisulfanediyl)-propanoic acid + RESID-alternate + + + Beta-methylthiolation + UniMod-description + + + L-3-(methyldithio)alanine + RESID-alternate + + + L-cysteine methyl disulfide + RESID-name + + + methyl methanethiolsulfonate derivatized cysteine + PSI-MOD-alternate + + + methyl methanethiosulfonate derivatized cysteine + PSI-MOD-alternate + + + Methylthio + PSI-MS-label + + + Methylthio + UniMod-interim + + + mmts + OMSSA-label + + + MOD_RES Cysteine methyl disulfide + UniProt-feature + + + S-methylthio-L-cysteine + RESID-alternate + + + S-methylthiocysteine + RESID-alternate + + + + DiffAvg + 46.09 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 1 + + + + DiffMono + 45.987721 + + + + Formula + C 4 H 7 N 1 O 1 S 2 + + + + MassAvg + 149.23 + + + + MassMono + 148.996906 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00848 + MOD:00905 + MOD:01153 + MOD:01862 + PSI-MOD + + + MOD:00111 + S-farnesyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. + + 293 + DeltaMass + + + 1409665 + PubMed + + + 15609361 + PubMed + + + 1872463 + PubMed + + + 2684976 + PubMed + + + AA0102 + RESID + + + 44#C + UniMod + + + From DeltaMass: (name misspelled "S-farnesyl cystenyl") + PSI-MOD-slim + + (2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid + RESID-alternate + + + Farnesyl + PSI-MS-label + + + Farnesylation + UniMod-description + + + farnesylationc + OMSSA-label + + + LIPID S-farnesyl cysteine + UniProt-feature + + + S-farnesyl Cystenyl + DeltaMass-label + + + S-farnesyl-L-cysteine + RESID-name + + + SFarnCys + PSI-MOD-label + + + + DiffAvg + 204.36 + + + + DiffFormula + C 15 H 24 N 0 O 0 S 0 + + + + DiffMono + 204.187801 + + + + Formula + C 18 H 29 N 1 O 1 S 1 + + + + MassAvg + 307.50 + + + + MassMono + 307.196986 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00437 + MOD:01110 + PSI-MOD + + + MOD:00112 + S-12-hydroxyfarnesyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. + + 17790543 + PubMed + + + AA0103 + RESID + + + 376 + UniMod + + + + (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid + RESID-alternate + + + Hydroxyfarnesyl + PSI-MS-label + + + hydroxyfarnesyl + UniMod-description + + + LIPID S-12-hydroxyfarnesyl cysteine + UniProt-feature + + + S-12-hydroxyfarnesyl-L-cysteine + RESID-name + + + S12HyFarnCys + PSI-MOD-label + + + + DiffAvg + 220.36 + + + + DiffFormula + C 15 H 24 N 0 O 1 S 0 + + + + DiffMono + 220.182715 + + + + Formula + C 18 H 29 N 1 O 2 S 1 + + + + MassAvg + 323.50 + + + + MassMono + 323.191900 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:01110 + PSI-MOD + + + MOD:00113 + S-geranylgeranyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. + + 0 + DeltaMass + + + 1483450 + PubMed + + + 15609361 + PubMed + + + AA0104 + RESID + + + 48#C + UniMod + + + DeltaMass calculates the mass with two double bonds rather than four + PSI-MOD-slim + + (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid + RESID-alternate + + + Geranyl-geranyl + UniMod-description + + + GeranylGeranyl + PSI-MS-label + + + geranylgeranylc + OMSSA-label + + + LIPID S-geranylgeranyl cysteine + UniProt-feature + + + S-geranylgeranyl + DeltaMass-label + + + S-geranylgeranyl-L-cysteine + RESID-name + + + SGergerCys + PSI-MOD-label + + + + DiffAvg + 272.48 + + + + DiffFormula + C 20 H 32 N 0 O 0 S 0 + + + + DiffMono + 272.250401 + + + + Formula + C 23 H 37 N 1 O 1 S 1 + + + + MassAvg + 375.62 + + + + MassMono + 375.259586 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00441 + MOD:01110 + PSI-MOD + + + MOD:00114 + L-cysteine methyl ester + + A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. + + 11875433 + PubMed + + + 1872463 + PubMed + + + AA0105 + RESID + + + 34#C-term + UniMod + + + Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. + PSI-MOD-slim + + 2-amino-3-mercaptopropanoic methyl ester + RESID-alternate + + + 2-amino-3-sulfanylpropanoic methyl ester + RESID-alternate + + + L-cysteine methyl ester + RESID-name + + + mecysteine + RESID-alternate + + + Methyl + PSI-MS-label + + + methyl (2R)-2-amino-3-sulfanylpropanoate + RESID-systematic + + + methyl esterified L-cysteine + PSI-MOD-alternate + + + methyl L-cysteinate + RESID-alternate + + + Methylation + UniMod-description + + + MOD_RES Cysteine methyl ester + UniProt-feature + + + OMeCys + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 0 + + + + DiffMono + 14.015650 + + + + Formula + C 4 H 8 N 1 O 2 S 1 + + + + MassAvg + 134.17 + + + + MassMono + 134.027574 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:01682 + MOD:01689 + PSI-MOD + + + MOD:00115 + S-palmitoyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. + + 303 + DeltaMass + + + 1872406 + PubMed + + + 3166978 + PubMed + + + 8180229 + PubMed + + + 8824274 + PubMed + + + AA0106 + RESID + + + 47#C + UniMod + + + From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556 + PSI-MOD-slim + + (2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(hexadecanoylthio)propanoic acid + RESID-alternate + + + ACT_SITE S-palmitoyl cysteine intermediate + UniProt-feature + + + cysteine hexadecanoate thioester + RESID-alternate + + + cysteine palmitate thioester + RESID-alternate + + + LIPID S-palmitoyl cysteine + UniProt-feature + + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + S-palmitoyl-L-cysteine + RESID-name + + + S-palmitoylated L-cysteine + PSI-MOD-alternate + + + S-palmityl Cystenyl + DeltaMass-label + + + SPamCys + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + C 19 H 35 N 1 O 2 S 1 + + + + MassAvg + 341.55 + + + + MassMono + 341.238850 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00653 + MOD:01684 + PSI-MOD + + + MOD:00116 + S-diacylglycerol-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. + + 10896212 + PubMed + + + 4575979 + PubMed + + + 9056182 + PubMed + + + AA0107 + RESID + + + 377#C + UniMod + + + Incidental to RESID:AA0060. + PSI-MOD-slim + + (2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid + RESID-systematic + + + 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid + RESID-alternate + + + Diacylglycerol + PSI-MS-label + + + diacylglycerol + UniMod-description + + + LIPID S-diacylglycerol cysteine + UniProt-feature + + + S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine + RESID-alternate + + + S-(2',3'-diacylglycerol)-L-cysteine + PSI-MOD-alternate + + + S-diacylglycerol-L-cysteine + RESID-name + + + SAcyl2GlyceroCys + PSI-MOD-label + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01155 + PSI-MOD + + + MOD:00117 + S-(L-isoglutamyl)-L-cysteine + + A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia. + + 22021 + ChEBI + + + 0 + DeltaMass + + + 6838833 + PubMed + + + AA0108 + RESID + + + Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. + PSI-MOD-slim + + (2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid + RESID-systematic + + + (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid + RESID-alternate + + + 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid + RESID-alternate + + + CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln) + UniProt-feature + + + gamma-(S-cysteinyl)glutamic acid + RESID-alternate + + + S-(L-isoglutamyl)-L-cysteine + RESID-name + + + S-gamma-glutamyl (crosslinked to cysteine) + DeltaMass-label + + + XLNK-SCys-5Glu(Gln) + PSI-MOD-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 S 0 + + + + DiffMono + -17.026549 + + + + Formula + C 8 H 10 N 2 O 3 S 1 + + + + MassAvg + 214.24 + + + + MassMono + 214.041213 + + + + Origin + C, Q + + + + Source + natural + + + + TermSpec + none + + MOD:00395 + MOD:00907 + MOD:00946 + PSI-MOD + + + MOD:00118 + 2'-(S-L-cysteinyl)-L-histidine + + A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. + + 0 + DeltaMass + + + 6210696 + PubMed + + + AA0109 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid + RESID-systematic + + + (2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid + RESID-alternate + + + 2'-(L-cystein-S-yl)-L-histidine + RESID-name + + + CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His) + UniProt-feature + + + S-(2'-histidyl)cysteine + RESID-alternate + + + S-(2-histidyl)- (crosslinked to cysteine) + DeltaMass-label + + + XLNK-SCys-2'His + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 9 H 10 N 4 O 2 S 1 + + + + MassAvg + 238.26 + + + + MassMono + 238.052447 + + + + Origin + C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00687 + MOD:00909 + PSI-MOD + + + MOD:00119 + L-lanthionine (Cys-Ser) + + A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. + + 21347 + ChEBI + + + 7 + DeltaMass + + + AA0110#CSX + RESID + + + Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG]. + + (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + RESID-systematic + + + (R)-S-(2-amino-2-carboxyethyl)-L-cysteine + RESID-alternate + + + (R,R)-2,6-diamino-4-thiaheptanedioic acid + RESID-alternate + + + (R,R)-3,3'-thiobis-(2-aminopropanoic acid) + RESID-alternate + + + (R,R)-bis(2-amino-2-carboxyethyl)sulfide + RESID-alternate + + + 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid + RESID-alternate + + + 3,3'-thiobis-L-alanine + RESID-alternate + + + L-lanthionine + RESID-name + + + XLNK-SCys-(L)3Dha + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + C, S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:00954 + MOD:01839 + PSI-MOD + + + MOD:00120 + meso-lanthionine + + A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. + + 15023056 + PubMed + + + 3769923 + PubMed + + + AA0111 + RESID + + + Cross-link 2. + + (2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid) + RESID-systematic + + + (2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid) + RESID-alternate + + + (2R,6S)-2,6-diamino-4-thiaheptanedioic acid + RESID-alternate + + + (2R,6S)-meso-lanthionine + RESID-alternate + + + (2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid + RESID-alternate + + + (2S,6R)-meso-lanthionine + RESID-misnomer + + + (R)-S-(2-amino-2-carboxyethyl)-D-cysteine + RESID-alternate + + + (R,S)-bis(2-amino-2-carboxyethyl)sulfide + RESID-alternate + + + 3,3'-thiobis-meso-alanine + RESID-alternate + + + CROSSLNK Lanthionine (Cys-Ser) + UniProt-feature + + + CROSSLNK Lanthionine (Ser-Cys) + UniProt-feature + + + cysteine-3-D-alanine thioether + RESID-alternate + + + meso-lanthionine + RESID-name + + + XLNK-SCys-(D)3Dha + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:00954 + MOD:01841 + PSI-MOD + + + MOD:00121 + (2S,3S,2'R)-3-methyllanthionine + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine. + + 3769923 + PubMed + + + AA0112 + RESID + + + Cross-link 2. + + (2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid + RESID-systematic + + + (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid + RESID-alternate + + + (2S,3S,2'R)-3-methyllanthionine + RESID-name + + + (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid + RESID-alternate + + + (2S,3S,6R)-3-methyllanthionine + RESID-alternate + + + (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid + RESID-alternate + + + 3-methyl-D,L-lanthionine + RESID-alternate + + + CROSSLNK Beta-methyllanthionine (Cys-Thr) + UniProt-feature + + + CROSSLNK Beta-methyllanthionine (Thr-Cys) + UniProt-feature + + + cysteine-3-D-butyrine thioether + RESID-alternate + + + XLNK-SCys-3Dhb + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 10 N 2 O 2 S 1 + + + + MassAvg + 186.23 + + + + MassMono + 186.046299 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:01981 + PSI-MOD + + + MOD:00122 + 3'-(S-L-cysteinyl)-L-tyrosine + + A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. + + 0 + DeltaMass + + + 15917234 + PubMed + + + 2002850 + PubMed + + + AA0113 + RESID + + + Cross-link 2. + + (2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid + RESID-systematic + + + 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid + RESID-alternate + + + 3'-(cystein-S-yl)tyrosine + RESID-alternate + + + 3'-(L-cystein-S-yl)-L-tyrosine + RESID-name + + + CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) + UniProt-feature + + + CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) + UniProt-feature + + + S-(3-Tyr) (Crosslinked to Cysteine) + DeltaMass-label + + + S-(tyros-3'-yl)cysteine + RESID-alternate + + + XLNK-SCys-3'Tyr + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 12 H 12 N 2 O 3 S 1 + + + + MassAvg + 264.30 + + + + MassMono + 264.056863 + + + + Origin + C, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00687 + MOD:00919 + PSI-MOD + + + MOD:00123 + N6-carboxy-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine. + + 11369851 + PubMed + + + 4436319 + PubMed + + + 637859 + PubMed + + + 7754395 + PubMed + + + AA0114 + RESID + + + 299#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(carboxyamino)hexanoic acid + RESID-systematic + + + 2-amino-6-carbamic hexanoic acid + RESID-alternate + + + Carboxy + UniMod-interim + + + Carboxylation + UniMod-description + + + lysine NZ-carboxylic acid + RESID-alternate + + + MOD_RES N6-carboxylysine + UniProt-feature + + + N6-carbamyllysine + RESID-misnomer + + + N6-carboxy-L-lysine + RESID-name + + + N6-carboxylysine + RESID-alternate + + + N6CbxLys + PSI-MOD-label + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 + + + + DiffMono + 43.989829 + + + + Formula + C 7 H 12 N 2 O 3 + + + + MassAvg + 172.18 + + + + MassMono + 172.084792 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01152 + PSI-MOD + + + MOD:00124 + N6-1-carboxyethyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine. + + 3123486 + PubMed + + + 8253186 + PubMed + + + 8421682 + PubMed + + + AA0115 + RESID + + + 378#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid + RESID-systematic + + + Carboxyethyl + PSI-MS-label + + + carboxyethyl + UniMod-description + + + MOD_RES N6-1-carboxyethyl lysine + UniProt-feature + + + N6-(1-carboxyethyl)-L-lysine + RESID-name + + + N6-(1-carboxyethyl)lysine + RESID-alternate + + + N6CbzEtLys + PSI-MOD-label + + + NZ-(1-carboxyethyl)lysine + RESID-alternate + + + + DiffAvg + 72.06 + + + + DiffFormula + C 3 H 4 N 0 O 2 + + + + DiffMono + 72.021129 + + + + Formula + C 9 H 16 N 2 O 3 + + + + MassAvg + 200.24 + + + + MassMono + 200.116092 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00125 + hypusine + + A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. + + 0 + DeltaMass + + + 6806267 + PubMed + + + 8108861 + PubMed + + + AA0116 + RESID + + + 379#K + UniMod + + + This modification occurs uniquely in translation initiation factor eIF-5A [JSG]. + PSI-MOD-slim + + (2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid + RESID-systematic + + + (2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid + RESID-alternate + + + (2S,9R)-hypusine + RESID-alternate + + + 2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid + RESID-alternate + + + Hypu + PSI-MOD-label + + + Hypusine + PSI-MS-label + + + hypusine + UniMod-description + + + L-hypusine + RESID-name + + + MOD_RES Hypusine + UniProt-feature + + + N-(4-NH2-2-OH-butyl)- (of Lysine) + DeltaMass-label + + + N6-(4-amino-2-hydroxybutyl)-L-lysine + RESID-alternate + + + + DiffAvg + 87.12 + + + + DiffFormula + C 4 H 9 N 1 O 1 + + + + DiffMono + 87.068414 + + + + Formula + C 10 H 21 N 3 O 2 + + + + MassAvg + 215.30 + + + + MassMono + 215.163377 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01884 + + derives_from + MOD:018800 + + PSI-MOD + + + MOD:00126 + N6-biotinyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine. + + 305 + DeltaMass + + + 16109483 + PubMed + + + 3178228 + PubMed + + + 7948875 + PubMed + + + 8747466 + PubMed + + + AA0117 + RESID + + + 3#K + UniMod + + + From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex. + PSI-MOD-slim + + (2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid + RESID-systematic + + + (3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine + RESID-alternate + + + biocytin + RESID-alternate + + + Biotin + PSI-MS-label + + + biotinyl lysyl + DeltaMass-label + + + Biotinylation + UniMod-description + + + epsilon-N-biotinyllysine + RESID-alternate + + + MOD_RES N6-biotinyllysine + UniProt-feature + + + N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine + RESID-alternate + + + N6-biotinyl-L-lysine + RESID-name + + + N6-biotinyllysine + RESID-alternate + + + N6BtnLys + PSI-MOD-label + + + + DiffAvg + 226.29 + + + + DiffFormula + C 10 H 14 N 2 O 2 S 1 + + + + DiffMono + 226.077599 + + + + Formula + C 16 H 26 N 4 O 3 S 1 + + + + MassAvg + 354.47 + + + + MassMono + 354.172562 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01875 + MOD:01885 + PSI-MOD + + + MOD:00127 + N6-lipoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine. + + 0 + DeltaMass + + + 3421911 + PubMed + + + 3522581 + PubMed + + + 7719855 + PubMed + + + AA0118 + RESID + + + 42#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid + RESID-alternate + + + (2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid + RESID-systematic + + + (2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid + RESID-alternate + + + 2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid + RESID-alternate + + + Lipoyl + PSI-MS-label + + + Lipoyl + UniMod-description + + + lipoylk + OMSSA-label + + + MOD_RES N6-lipoyllysine + UniProt-feature + + + N-Lipoyl- (on Lysine) + DeltaMass-label + + + N6-6,8-dithiooctanoyllysine + RESID-alternate + + + N6-lipoyl-L-lysine + RESID-name + + + N6-lipoyllysine + RESID-alternate + + + N6LipLys + PSI-MOD-label + + + + DiffAvg + 188.30 + + + + DiffFormula + C 8 H 12 N 0 O 1 S 2 + + + + DiffMono + 188.032957 + + + + Formula + C 14 H 24 N 2 O 2 S 2 + + + + MassAvg + 316.48 + + + + MassMono + 316.127920 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01875 + PSI-MOD + + + MOD:00128 + N6-pyridoxal phosphate-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine. + + 0 + DeltaMass + + + 1544460 + PubMed + + + AA0119 + RESID + + + 46#K + UniMod + + + From DeltaMass: Average Mass: 231 + PSI-MOD-slim + + (2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid + RESID-systematic + + + MOD_RES N6-(pyridoxal phosphate)lysine + UniProt-feature + + + N6-pyridoxal phosphate-L-lysine + RESID-name + + + N6PydoxLys + PSI-MOD-label + + + Pyridoxal phosphate + UniMod-description + + + Pyridoxal phosphate (Schiff Base formed to lysine) + DeltaMass-label + + + PyridoxalPhosphate + PSI-MS-label + + + + DiffAvg + 229.13 + + + + DiffFormula + C 8 H 8 N 1 O 5 P 1 + + + + DiffMono + 229.014009 + + + + Formula + C 14 H 20 N 3 O 6 P 1 + + + + MassAvg + 357.30 + + + + MassMono + 357.108972 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00129 + N6-retinylidene-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal. + + 6794028 + PubMed + + + 6870827 + PubMed + + + AA0120 + RESID + + + 380#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid + RESID-systematic + + + MOD_RES N6-(retinylidene)lysine + UniProt-feature + + + N6-retinal-L-lysine + RESID-alternate + + + N6-retinyl-lysine + RESID-alternate + + + N6-retinylidene-L-lysine + RESID-name + + + N6RetalLys + PSI-MOD-label + + + retinal + UniMod-description + + + Retinylidene + PSI-MS-label + + + + DiffAvg + 266.43 + + + + DiffFormula + C 20 H 26 N 0 O 0 + + + + DiffMono + 266.203451 + + + + Formula + C 26 H 38 N 2 O 1 + + + + MassAvg + 394.60 + + + + MassMono + 394.298414 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00130 + L-allysine + + A protein modification that effectively converts an L-lysine residue to L-allysine. + + 17917 + ChEBI + + + 0 + DeltaMass + + + 11120890 + PubMed + + + 11332453 + PubMed + + + 358196 + PubMed + + + 5337886 + PubMed + + + 5529814 + PubMed + + + AA0121 + RESID + + + 352#K + UniMod + + + From DeltaMass: Average Mass: -1 + PSI-MOD-slim + + (2S)-2-amino-6-oxohexanoic acid + RESID-systematic + + + 2-amino-5-formylvaleric acid + RESID-alternate + + + 2-amino-adipic acid semialdahyde + RESID-alternate + + + 2-aminoadipate 6-semialdehyde + RESID-alternate + + + 5-formyl-norvaline + RESID-alternate + + + 6-oxonorleucine + RESID-alternate + + + AASA + RESID-alternate + + + Allysine (from Lysine) + DeltaMass-label + + + alpha-amino-adipic acid delta-semialdahyde + RESID-alternate + + + L-allysine + RESID-name + + + Lys->Allysine + PSI-MS-label + + + Lysal + PSI-MOD-label + + + Lysine oxidation to aminoadipic semialdehyde + UniMod-description + + + MOD_RES Allysine + UniProt-feature + + + Oxidation of lysine (to aminoadipic semialdehyde) + DeltaMass-label + + + + DiffAvg + -1.03 + + + + DiffFormula + C 0 H -3 N -1 O 1 + + + + DiffMono + -1.031634 + + + + Formula + C 6 H 9 N 1 O 2 + + + + MassAvg + 127.14 + + + + MassMono + 127.063329 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00131 + L-2-aminoadipic acid + + A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid. + + 353 + DeltaMass + + + 336041 + PubMed + + + 358196 + PubMed + + + 7419498 + PubMed + + + AA0122 + RESID + + + 381#K + UniMod + + + From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG] + PSI-MOD-slim + + (2S)-2-aminohexanedioic acid + RESID-systematic + + + 2-amino-1,4-butanedicarboxylic acid + RESID-alternate + + + alpha-amino adipic acid + UniMod-description + + + L-2-aminoadipic acid + RESID-name + + + L-alpha-aminoadipic acid + RESID-alternate + + + Lys->AminoadipicAcid + PSI-MS-label + + + Lysoic + PSI-MOD-label + + + Oxidation of lysine (to aminoadipic acid) + DeltaMass-label + + + + DiffAvg + 14.97 + + + + DiffFormula + C 0 H -3 N -1 O 2 + + + + DiffMono + 14.963280 + + + + Formula + C 6 H 9 N 1 O 3 + + + + MassAvg + 143.14 + + + + MassMono + 143.058243 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00132 + L-lysinoalanine (Lys-Ser) + + A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. + + 0 + DeltaMass + + + 2544544 + PubMed + + + AA0123#KSX + RESID + + + Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34. + + (2R,9S)-lysinoalanine + RESID-alternate + + + (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid + RESID-systematic + + + alaninolysine + RESID-alternate + + + CROSSLNK Lysinoalanine (Ser-Lys) + UniProt-feature + + + L-lysinoalanine + RESID-name + + + LAL + RESID-alternate + + + Lysinoalanine (from Cysteine) + DeltaMass-label + + + N-epsilon-(2-amino-2-carboxyethyl)-L-lysine + RESID-alternate + + + N6-(2-amino-2-carboxyethyl)-L-lysine + RESID-alternate + + + XLNK-N6Lys-3Dha(Ser) + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 9 H 15 N 3 O 2 + + + + MassAvg + 197.24 + + + + MassMono + 197.116427 + + + + Origin + K, S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:00954 + MOD:01853 + PSI-MOD + + + MOD:00133 + N6-(L-isoglutamyl)-L-lysine (Gln) + + A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia. + + 21863 + ChEBI + + + 0 + DeltaMass + + + 2461365 + PubMed + + + 5637041 + PubMed + + + 5656070 + PubMed + + + 8598899 + PubMed + + + AA0124#GLN + RESID + + + Cross-link 2. + PSI-MOD-slim + + (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid + RESID-systematic + + + 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid + RESID-alternate + + + 5-glutamyl N6-lysine + RESID-alternate + + + CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln) + UniProt-feature + + + N alpha -(gamma-Glutamyl)-lysine + DeltaMass-label + + + N(epsilon)-(gamma-glutamyl)lysine + RESID-alternate + + + N6-(L-isoglutamyl)-L-lysine + RESID-name + + + XLNK-N6Lys-5Glu(Gln) + PSI-MOD-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 11 H 17 N 3 O 3 + + + + MassAvg + 239.27 + + + + MassMono + 239.126991 + + + + Origin + K, Q + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + MOD:00946 + MOD:01630 + PSI-MOD + + + MOD:00134 + N6-glycyl-L-lysine + + A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine. + + 21885 + ChEBI + + + AA0125 + RESID + + + Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins. + PSI-MOD-slim + + (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid + RESID-systematic + + + N6-(glycyl)-L-lysine + RESID-name + + + N6-glycyllysine + RESID-alternate + + + XLNK-N6Lys-1Gly + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 8 H 14 N 3 O 2 + + + + MassAvg + 184.22 + + + + MassMono + 184.108602 + + + + Origin + G, K + + + + Source + natural + + + + TermSpec + C-term + + MOD:00688 + MOD:00908 + MOD:00954 + MOD:01875 + PSI-MOD + + + MOD:00135 + N-(L-isoaspartyl)-glycine (Asn) + + A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia. + + 21479 + ChEBI + + + 1826288 + PubMed + + + AA0126 + RESID + + + Cross-link 2. + + (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid + RESID-systematic + + + 2-amino-N4-(carboxymethyl)-butanediamic acid + RESID-alternate + + + CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly) + UniProt-feature + + + CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn) + UniProt-feature + + + isoaspartyl glycine + RESID-alternate + + + N-(L-isoaspartyl)-glycine + RESID-name + + + N-beta-aspartylglycine + RESID-alternate + + + N4-(carboxymethyl)-asparagine + RESID-alternate + + + XLNK-4Asp-NGly(Asn) + PSI-MOD-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 6 H 7 N 2 O 3 + + + + MassAvg + 155.13 + + + + MassMono + 155.045667 + + + + Origin + G, N + + + + Source + natural + + + + TermSpec + N-term + + MOD:00903 + MOD:00946 + MOD:01928 + PSI-MOD + + + MOD:00136 + pyruvic acid (Cys) + + A protein modification that effectively converts an L-cysteine residue to pyruvic acid. + + 10085076 + PubMed + + + 3042771 + PubMed + + + 8464063 + PubMed + + + AA0127#CYS + RESID + + + 382 + UniMod + + + PSI-MOD-slim + + 2-oxopropanoic acid + RESID-systematic + + + MOD_RES Pyruvic acid (Cys) + UniProt-feature + + + Pyruv(Cys) + PSI-MOD-label + + + pyruvic acid + RESID-name + + + + DiffAvg + -33.09 + + + + DiffFormula + C 0 H -3 N -1 O 1 S -1 + + + + DiffMono + -33.003705 + + + + Formula + C 3 H 3 O 2 + + + + MassAvg + 71.06 + + + + MassMono + 71.013304 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + MOD:01154 + PSI-MOD + + + MOD:00137 + L-3-phenyllactic acid + + A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid. + + 1973541 + PubMed + + + AA0128 + RESID + + + 7#F + UniMod + + + This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group. + + (2S)-2-hydroxy-3-phenylpropanoic acid + RESID-systematic + + + Deamidated + UniMod-interim + + + Deamidation + UniMod-description + + + L-3-phenyllactic acid + RESID-name + + + MOD_RES 3-phenyllactic acid + UniProt-feature + + + + DiffAvg + 0.98 + + + + DiffFormula + C 0 H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + C 9 H 9 O 2 + + + + MassAvg + 149.17 + + + + MassMono + 149.060255 + + + + Origin + F + + + + TermSpec + N-term + + MOD:00914 + PSI-MOD + + + MOD:00138 + 2-oxobutanoic acid + + A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid. + + 15023056 + PubMed + + + 1680314 + PubMed + + + 2253617 + PubMed + + + 2764678 + PubMed + + + AA0129 + RESID + + + 385#T + UniMod + + + + 2-ketobutyric acid + RESID-alternate + + + 2-oxobutanoic acid + RESID-name + + + 2-oxobutanoic acid + RESID-systematic + + + 2-oxobutyric acid + RESID-alternate + + + Ammonia-loss + UniMod-interim + + + Loss of ammonia + UniMod-description + + + MOD_RES 2-oxobutanoic acid + UniProt-feature + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 4 H 5 O 2 + + + + MassAvg + 85.08 + + + + MassMono + 85.028954 + + + + Origin + T + + + + TermSpec + N-term + + MOD:00917 + MOD:01160 + PSI-MOD + + + MOD:00139 + N2-succinyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 8471040 + PubMed + + + AA0130 + RESID + + + 64#N-term + UniMod + + + + (2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid + RESID-systematic + + + (2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid + RESID-alternate + + + MOD_RES N2-succinyltryptophan + UniProt-feature + + + N2-succinyl-L-tryptophan + RESID-name + + + Succinic anhydride labeling reagent light form (N-term) + UniMod-description + + + Succinyl + PSI-MS-label + + + + DiffAvg + 100.07 + + + + DiffFormula + C 4 H 4 N 0 O 3 + + + + DiffMono + 100.016044 + + + + Formula + C 15 H 15 N 2 O 4 + + + + MassAvg + 287.29 + + + + MassMono + 287.103182 + + + + Origin + W + + + + TermSpec + N-term + + MOD:00457 + MOD:00918 + PSI-MOD + + + MOD:00140 + S-phycocyanobilin-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin. + + 15617 + ChEBI + + + 0 + DeltaMass + + + 16644722 + PubMed + + + 3208761 + PubMed + + + 3838747 + PubMed + + + 7918400 + PubMed + + + AA0131 + RESID + + + 387#C + UniMod + + + From DeltaMass: Average Mass: 587. + + (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid + RESID-alternate + + + (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione + RESID-systematic + + + BINDING Phycocyanobilin chromophore (covalent; via 1 link) + UniProt-feature + + + PCB + RESID-alternate + + + phycobilin cysteine + RESID-alternate + + + Phycocyanobilin + PSI-MS-label + + + phycocyanobilin + UniMod-description + + + phycocyanobilin cysteine adduct + RESID-alternate + + + S-Phycocyanobilin (on Cysteine) + DeltaMass-label + + + S-phycocyanobilin-L-cysteine + RESID-name + + + + DiffAvg + 586.69 + + + + DiffFormula + C 33 H 38 N 4 O 6 S 0 + + + + DiffMono + 586.279135 + + + + Formula + C 36 H 43 N 5 O 7 S 1 + + + + MassAvg + 689.83 + + + + MassMono + 689.288320 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:00141 + S-phycoerythrobilin-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin. + + 15618 + ChEBI + + + 14588022 + PubMed + + + 3208761 + PubMed + + + 3838747 + PubMed + + + 8876649 + PubMed + + + AA0132 + RESID + + + 388#C + UniMod + + + + (2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione + RESID-systematic + + + 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid + RESID-alternate + + + BINDING Phycoerythrobilin chromophore (covalent; via 1 link) + UniProt-feature + + + PEB + RESID-alternate + + + Phycoerythrobilin + PSI-MS-label + + + phycoerythrobilin + UniMod-description + + + phycoerythrobilin cysteine adduct + RESID-alternate + + + S-phycoerythrobilin-L-cysteine + RESID-name + + + + DiffAvg + 588.70 + + + + DiffFormula + C 33 H 40 N 4 O 6 S 0 + + + + DiffMono + 588.294785 + + + + Formula + C 36 H 45 N 5 O 7 S 1 + + + + MassAvg + 691.84 + + + + MassMono + 691.303970 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:00142 + S-phytochromobilin-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin. + + 15619 + ChEBI + + + 1634523 + PubMed + + + 16593380 + PubMed + + + 3208761 + PubMed + + + 7918400 + PubMed + + + AA0133 + RESID + + + 389#C + UniMod + + + + (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione + RESID-systematic + + + 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid + RESID-alternate + + + BINDING Phytochromobilin chromophore (covalent; via 1 link) + UniProt-feature + + + phytochrome chromophore + RESID-alternate + + + Phytochromobilin + PSI-MS-label + + + phytochromobilin + UniMod-description + + + phytochromobilin cysteine adduct + RESID-alternate + + + S-phytochromobilin-L-cysteine + RESID-name + + + + DiffAvg + 584.67 + + + + DiffFormula + C 33 H 36 N 4 O 6 S 0 + + + + DiffMono + 584.263485 + + + + Formula + C 36 H 41 N 5 O 7 S 1 + + + + MassAvg + 687.81 + + + + MassMono + 687.272670 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:00143 + heme-bis-L-cysteine + + A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 17627 + ChEBI + + + 5545094 + PubMed + + + 8827449 + PubMed + + + AA0134 + RESID + + + Cross-link 2. + PSI-MOD-slim + + (7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate + RESID-systematic + + + 2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX + RESID-alternate + + + BINDING Heme (covalent) + UniProt-feature + + + biscysteinyl heme + RESID-alternate + + + heme-bis-L-cysteine + RESID-name + + + HemeCys2 + PSI-MOD-label + + + + DiffAvg + 616.50 + + + + DiffFormula + C 34 Fe 1 H 32 N 4 O 4 S 0 + + + + DiffMono + 616.177293 + + + + Formula + C 40 Fe 1 H 42 N 6 O 6 S 2 + + + + MassAvg + 822.78 + + + + MassMono + 822.195663 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00905 + PSI-MOD + + + MOD:00144 + heme-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 17627 + ChEBI + + + 0 + DeltaMass + + + 170910 + PubMed + + + 192772 + PubMed + + + 2536325 + PubMed + + + 9535866 + PubMed + + + AA0135 + RESID + + + 390#C + UniMod + + + From DeltaMass: Average Mass: 617. + PSI-MOD-slim + + (12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate + RESID-systematic + + + 4-[1-(S-cysteinyl)ethyl]protoporphyrin IX + RESID-alternate + + + BINDING Heme (covalent; via 1 link) + UniProt-feature + + + cysteinyl heme + RESID-alternate + + + Heme + PSI-MS-label + + + heme + UniMod-description + + + heme-L-cysteine + RESID-name + + + HemeCys1 + PSI-MOD-label + + + S-Heme (on Cysteine) + DeltaMass-label + + + + DiffAvg + 616.50 + + + + DiffFormula + C 34 Fe 1 H 32 N 4 O 4 S 0 + + + + DiffMono + 616.177293 + + + + Formula + C 37 Fe 1 H 37 N 5 O 5 S 1 + + + + MassAvg + 719.64 + + + + MassMono + 719.186478 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00905 + PSI-MOD + + + MOD:00145 + tetrakis-L-cysteinyl iron + + A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron. + + 1303768 + PubMed + + + 2244884 + PubMed + + + AA0136 + RESID + + + Cross-link 4. + + METAL Iron + UniProt-feature + + + tetrakis(cysteinato-kappaS)-iron + RESID-systematic + + + tetrakis-L-cysteinyl iron + RESID-name + + + + DiffAvg + 51.81 + + + + DiffFormula + C 0 Fe 1 H -4 N 0 O 0 S 0 + + + + DiffMono + 51.904735 + + + + FormalCharge + 2- + + + + Formula + C 12 Fe 1 H 16 N 4 O 4 S 4 + + + + MassAvg + 464.37 + + + + MassMono + 463.941474 + + + + Origin + C, C, C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00738 + MOD:00905 + PSI-MOD + + + MOD:00146 + tetrakis-L-cysteinyl diiron disulfide + + A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide. + + 2123937 + PubMed + + + 6801028 + PubMed + + + 7763242 + PubMed + + + 8688437 + PubMed + + + AA0137 + RESID + + + Cross-link 4. + + METAL Iron-sulfur (2Fe-2S) + UniProt-feature + + + METAL Iron-sulfur (2Fe-2S); shared with dimeric partner + UniProt-feature + + + tetrakis-L-cysteinyl diiron disulfide + RESID-name + + + tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron + RESID-systematic + + + + DiffAvg + 171.78 + + + + DiffFormula + C 0 Fe 2 H -4 N 0 O 0 S 2 + + + + DiffMono + 171.783814 + + + + FormalCharge + 2- + + + + Formula + C 12 Fe 2 H 16 N 4 O 4 S 6 + + + + MassAvg + 584.34 + + + + MassMono + 583.820553 + + + + Origin + C, C, C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00147 + hexakis-L-cysteinyl triiron trisulfide + + A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide. + + 3379067 + PubMed + + + 3932661 + PubMed + + + 7354058 + PubMed + + + AA0138 + RESID + + + Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + hexakis-L-cysteinyl triiron trisulfide + RESID-name + + + tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron + RESID-systematic + + + tri-mu-sulfidotris(biscysteinato-kappaS-iron) + RESID-alternate + + + + DiffAvg + 257.67 + + + + DiffFormula + C 0 Fe 3 H -6 N 0 O 0 S 3 + + + + DiffMono + 257.675721 + + + + FormalCharge + 3- + + + + Formula + C 18 Fe 3 H 24 N 6 O 6 S 9 + + + + MassAvg + 876.50 + + + + MassMono + 875.730830 + + + + Origin + C, C, C, C, C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00148 + tris-L-cysteinyl triiron tetrasulfide + + A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide. + + 10555576 + PubMed + + + 2056535 + PubMed + + + 3422475 + PubMed + + + 6848518 + PubMed + + + 7819255 + PubMed + + + 9063899 + PubMed + + + AA0139 + RESID + + + Cross-link 3. + + METAL Iron-sulfur (3Fe-4S) + UniProt-feature + + + mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron + RESID-alternate + + + mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron + RESID-systematic + + + tris-L-cysteinyl triiron tetrasulfide + RESID-name + + + tris-L-cysteinyl triiron tetrasulfide C3 cluster + RESID-alternate + + + tris-L-cysteinyl triiron tetrasulfide cubane form + RESID-alternate + + + tris-L-cysteinyl triiron tetrasulfide cuboid cluster + RESID-alternate + + + tris-L-cysteinyl triiron tetrasulfide trigonal cluster + RESID-alternate + + + + DiffAvg + 292.75 + + + + DiffFormula + C 0 Fe 3 H -3 N 0 O 0 S 4 + + + + DiffMono + 292.671267 + + + + FormalCharge + 3- + + + + Formula + C 9 Fe 3 H 12 N 3 O 3 S 7 + + + + MassAvg + 602.17 + + + + MassMono + 601.698821 + + + + Origin + C, C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00149 + tetrakis-L-cysteinyl tetrairon tetrasulfide + + A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide. + + 3351918 + PubMed + + + 7803404 + PubMed + + + 7819196 + PubMed + + + 932007 + PubMed + + + AA0140 + RESID + + + Cross-link 4. + + METAL Iron-sulfur (4Fe-4S) + UniProt-feature + + + METAL Iron-sulfur (4Fe-4S); shared with dimeric partner + UniProt-feature + + + tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon + RESID-systematic + + + tetra-mu3-sulfidotetrakis(S-cysteinyliron) + RESID-alternate + + + tetrakis-L-cysteinyl tetrairon tetrasulfide + RESID-name + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.597831 + + + + FormalCharge + 2- + + + + Formula + C 12 Fe 4 H 16 N 4 O 4 S 8 + + + + MassAvg + 760.15 + + + + MassMono + 759.634570 + + + + Origin + C, C, C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00150 + L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide + + A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide. + + 10525412 + PubMed + + + 12215645 + PubMed + + + 12733878 + PubMed + + + 1529354 + PubMed + + + 8027059 + PubMed + + + AA0141 + RESID + + + Cross-link 2; incidental to RESID:AA0300. + + cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon + RESID-systematic + + + L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide + RESID-name + + + nitrogenase iron-molybdenum cofactor + RESID-alternate + + + + DiffAvg + 991.53 + + + + DiffFormula + C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9 + + + + DiffMono + 993.213036 + + + + Formula + C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10 + + + + MassAvg + 1231.81 + + + + MassMono + 1233.281133 + + + + Origin + C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00743 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00151 + L-cysteinyl molybdopterin + + A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin. + + 14527393 + PubMed + + + 7878465 + PubMed + + + 9428520 + PubMed + + + AA0142 + RESID + + + 391#C + UniMod + + + PSI-MOD-slim + + (4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene + RESID-systematic + + + cysteinyl Mo-molybdopterin + RESID-alternate + + + cysteinyl Mo-pterin + RESID-alternate + + + L-cysteinyl molybdopterin + RESID-name + + + METAL Molybdenum-pterin + UniProt-feature + + + molybdoenzyme molybdenum cofactor + RESID-alternate + + + Molybdopterin + PSI-MS-label + + + molybdopterin + UniMod-description + + + MoPterCys + PSI-MOD-label + + + + DiffAvg + 520.27 + + + + DiffFormula + C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 + + + + DiffMono + 521.884074 + + + + Formula + C 13 H 16 Mo 1 N 6 O 9 P 1 S 3 + + + + MassAvg + 623.41 + + + + MassMono + 624.893259 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00744 + MOD:00861 + MOD:00905 + PSI-MOD + + + MOD:00152 + S-(8alpha-FAD)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine. + + 10220347 + PubMed + + + AA0143 + RESID + + + 50#C + UniMod + + + PSI-MOD-slim + + (2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid + RESID-systematic + + + 8alpha-(S-cysteinyl)FAD + RESID-alternate + + + FAD + PSI-MS-label + + + Flavin adenine dinucleotide + UniMod-description + + + MOD_RES S-8alpha-FAD cysteine + UniProt-feature + + + S-(8alpha-FAD)-L-cysteine + RESID-name + + + S8aFADCys + PSI-MOD-label + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 S 0 + + + + DiffMono + 783.141485 + + + + Formula + C 30 H 36 N 10 O 16 P 2 S 1 + + + + MassAvg + 886.68 + + + + MassMono + 886.150669 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00895 + MOD:00905 + PSI-MOD + + + MOD:00153 + 3'-(8alpha-FAD)-L-histidine + + A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine. + + 241294 + PubMed + + + 8076 + PubMed + + + AA0144 + RESID + + + 50#H + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid + RESID-systematic + + + 3'-(8alpha-FAD)-L-histidine + RESID-name + + + 8alpha-(N(delta)-histidyl)FAD + RESID-alternate + + + 8alpha-(N3'-histidyl)FAD + RESID-alternate + + + 8alpha-N1-histidyl FAD + RESID-misnomer + + + FAD + PSI-MS-label + + + Flavin adenine dinucleotide + UniMod-description + + + MOD_RES Pros-8alpha-FAD histidine + UniProt-feature + + + N(pi)-(8alpha-FAD)-histidine + RESID-alternate + + + Np8aFADHis + PSI-MOD-label + + + pros-(8alpha-FAD)-histidine + RESID-alternate + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 + + + + DiffMono + 783.141485 + + + + Formula + C 33 H 38 N 12 O 16 P 2 + + + + MassAvg + 920.68 + + + + MassMono + 920.200396 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00895 + MOD:00909 + PSI-MOD + + + MOD:00154 + O4'-(8alpha-FAD)-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine. + + 0 + DeltaMass + + + 7391034 + PubMed + + + AA0145 + RESID + + + 50#Y + UniMod + + + From DeltaMass: Average Mass: 783 + PSI-MOD-slim + + (2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid + RESID-systematic + + + 8alpha-(O4'-tyrosyl)FAD + RESID-alternate + + + FAD + PSI-MS-label + + + Flavin adenine dinucleotide + UniMod-description + + + MOD_RES O-8alpha-FAD tyrosine + UniProt-feature + + + O-8 alpha-Flavin [FAD])- (of Tyrosine) + DeltaMass-label + + + O4'-(8alpha-FAD)-L-tyrosine + RESID-name + + + O8aFADTyr + PSI-MOD-label + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 + + + + DiffMono + 783.141485 + + + + Formula + C 36 H 40 N 10 O 17 P 2 + + + + MassAvg + 946.72 + + + + MassMono + 946.204813 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00895 + MOD:00919 + PSI-MOD + + + MOD:00155 + 3'-hydroxylation of L-tyrosine to L-3',4'-dihydroxyphenylalanine + + A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine. + + 0 + DeltaMass + + + 1610822 + PubMed + + + 1903612 + PubMed + + + 3734192 + PubMed + + + AA0146 + RESID + + + 35#Y + UniMod + + + incidental to RESID:AA0368 From DeltaMass: Average Mass: 16 + PSI-MOD-slim + + (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid + RESID-systematic + + + 3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA) + DeltaMass-label + + + 3HyTyr + PSI-MOD-label + + + hydroxylationy + OMSSA-label + + + L-3',4'-dihydroxyphenylalanine + RESID-name + + + L-3'-hydroxytyrosine + RESID-alternate + + + L-DOPA + RESID-alternate + + + levodopa + RESID-alternate + + + mod194 + OMSSA-label + + + MOD_RES 3',4'-dihydroxyphenylalanine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 9 H 9 N 1 O 3 + + + + MassAvg + 179.18 + + + + MassMono + 179.058243 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00707 + PSI-MOD + + + MOD:00156 + oxidation of tyrosine to L-2',4',5'-topaquinone + + A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone. + + 21187 + ChEBI + + + 10387067 + PubMed + + + 1457410 + PubMed + + + 1569055 + PubMed + + + 2111581 + PubMed + + + AA0147 + RESID + + + 392#Y + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid + RESID-systematic + + + 2,4,5-trihydroxyphenylalanine quinone + RESID-alternate + + + 5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone + RESID-alternate + + + L-2',4',5'-topaquinone + RESID-name + + + L-2,4,5-TOPAquinone + RESID-alternate + + + MOD_RES 2',4',5'-topaquinone + UniProt-feature + + + Quinone + PSI-MS-label + + + quinone + UniMod-description + + + TopaQ + PSI-MOD-label + + + TPQ + RESID-alternate + + + + DiffAvg + 29.98 + + + + DiffFormula + C 0 H -2 N 0 O 2 + + + + DiffMono + 29.974179 + + + + Formula + C 9 H 7 N 1 O 4 + + + + MassAvg + 193.16 + + + + MassMono + 193.037508 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00679 + MOD:00919 + PSI-MOD + + + MOD:00157 + oxidation of tryptophan to L-tryptophyl quinone + + A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone. + + 0 + DeltaMass + + + 2028257 + PubMed + + + AA0148 + RESID + + + 392#W + UniMod + + + incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30. + PSI-MOD-slim + + (2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid + RESID-alternate + + + 3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione + RESID-alternate + + + 6,7 Dione (from Tryptophan) + DeltaMass-label + + + L-tryptophyl quinone + RESID-name + + + MOD_RES Tryptophylquinone + UniProt-feature + + + N-(3-carboxy-1-oxopropyl)-L-tryptophan + RESID-alternate + + + Quinone + PSI-MS-label + + + quinone + UniMod-description + + + TrpQ + PSI-MOD-label + + + + DiffAvg + 29.98 + + + + DiffFormula + C 0 H -2 N 0 O 2 + + + + DiffMono + 29.974179 + + + + Formula + C 11 H 8 N 2 O 3 + + + + MassAvg + 216.20 + + + + MassMono + 216.053492 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00679 + MOD:00918 + PSI-MOD + + + MOD:00158 + 4'-(L-tryptophan)-L-tryptophyl quinone + + A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone. + + 20251 + ChEBI + + + 0 + DeltaMass + + + 2028257 + PubMed + + + AA0149 + RESID + + + Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28. + PSI-MOD-slim + + 2,4-BisTrp-6,7-dione (from Tryptophan) + DeltaMass-label + + + 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid + RESID-alternate + + + 3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione + RESID-systematic + + + 4'-tryptophan-tryptophylquinone + RESID-alternate + + + 4-(2'-tryptophyl)tryptophan-6,7-dione + RESID-alternate + + + 4-(L-tryptophan-2-yl)-L-tryptophyl quinone + RESID-name + + + alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid + RESID-alternate + + + CROSSLNK Tryptophan tryptophylquinone (Trp-Trp) + UniProt-feature + + + TTQ + RESID-alternate + + + XLNK-4'Trp-TrpQ + PSI-MOD-label + + + + DiffAvg + 27.97 + + + + DiffFormula + C 0 H -4 N 0 O 2 + + + + DiffMono + 27.958529 + + + + Formula + C 22 H 16 N 4 O 4 + + + + MassAvg + 400.39 + + + + MassMono + 400.117155 + + + + Origin + W, W + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00918 + PSI-MOD + + + MOD:00159 + O-phosphopantetheine-L-serine + + A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine. + + 0 + DeltaMass + + + 10320345 + PubMed + + + 10997907 + PubMed + + + 12057197 + PubMed + + + 12869567 + PubMed + + + 4568609 + PubMed + + + AA0150 + RESID + + + 49#S + UniMod + + + UniMod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339 + PSI-MOD-slim + + (2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide + RESID-systematic + + + 4'-Phosphopantetheine + DeltaMass-label + + + MOD_RES O-(pantetheine 4'-phosphoryl)serine + UniProt-feature + + + O-phosphopantetheine-L-serine + RESID-name + + + OPpantSer + PSI-MOD-label + + + Phosphopantetheine + PSI-MS-label + + + Phosphopantetheine + UniMod-description + + + + DiffAvg + 340.33 + + + + DiffFormula + C 11 H 21 N 2 O 6 P 1 S 1 + + + + DiffMono + 340.085794 + + + + Formula + C 14 H 26 N 3 O 8 P 1 S 1 + + + + MassAvg + 427.41 + + + + MassMono + 427.117822 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:00160 + N4-glycosyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine. + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + PSI-MOD-slim + + N4GlycoAsn + PSI-MOD-label + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00006 + MOD:00903 + PSI-MOD + + + MOD:00161 + S-glucosyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine. + + 1145128 + PubMed + + + 15279557 + PubMed + + + 5286858 + PubMed + + + AA0152 + RESID + + + 41#C + UniMod + + + + (2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid + RESID-systematic + + + CARBOHYD S-linked (Glc) + UniProt-feature + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + S-(beta-D-glucopyranosyl)cysteine + RESID-alternate + + + S-glucosyl-L-cysteine + RESID-name + + + S-glycosyl-cysteine + RESID-alternate + + + SGlcCys + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 S 0 + + + + DiffMono + 162.052823 + + + + Formula + C 9 H 15 N 1 O 6 S 1 + + + + MassAvg + 265.28 + + + + MassMono + 265.062008 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00426 + MOD:00433 + MOD:00761 + MOD:00905 + PSI-MOD + + + MOD:00162 + O5-glucosylgalactosyl-L-hydroxylysine + + A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine. + + 15149698 + PubMed + + + 4288358 + PubMed + + + 4319110 + PubMed + + + AA0153 + RESID + + + 393 + UniMod + + + Secondary to RESID:AA0028. + PSI-MOD-slim + + (2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid + RESID-systematic + + + 5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine + RESID-alternate + + + Glucosylgalactosyl + PSI-MS-label + + + glucosylgalactosyl hydroxylysine + UniMod-description + + + O5-glucosylgalactosyl-L-hydroxylysine + RESID-name + + + OGlcGal5HyLys + PSI-MOD-label + + + + DiffAvg + 340.28 + + + + DiffFormula + C 12 H 20 N 0 O 11 + + + + DiffMono + 340.100561 + + + + Formula + C 18 H 32 N 2 O 12 + + + + MassAvg + 468.46 + + + + MassMono + 468.195524 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00037 + MOD:00396 + MOD:00476 + MOD:00726 + PSI-MOD + + + MOD:00163 + O-(N-acetylamino)galactosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine. + + 115869 + PubMed + + + 16005634 + PubMed + + + 3086323 + PubMed + + + 8948436 + PubMed + + + 9092502 + PubMed + + + AA0154 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (GalNAc) + UniProt-feature + + + HexNAc + PSI-MS-label + + + mucin type O-glycosylserine + RESID-alternate + + + O-(N-acetylamino)galactosyl-L-serine + RESID-name + + + O3-(N-acetylgalactosaminyl)serine + RESID-alternate + + + OGalNAcSer + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 11 H 18 N 2 O 7 + + + + MassAvg + 290.27 + + + + MassMono + 290.111401 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00563 + MOD:01675 + PSI-MOD + + + MOD:00164 + O-(N-acetylamino)galactosyl-L-threonine + + A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine. + + 16005634 + PubMed + + + 1997327 + PubMed + + + 3086323 + PubMed + + + 8948436 + PubMed + + + 9092502 + PubMed + + + AA0155 + RESID + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid + RESID-systematic + + + CARBOHYD O-linked (GalNAc) + UniProt-feature + + + CARBOHYD O-linked (HexNAc) + UniProt-feature + + + HexNAc + PSI-MS-label + + + mucin type O-glycosylthreonine + RESID-alternate + + + O-(N-acetylamino)galactosyl-L-threonine + RESID-name + + + O3-(N-acetylgalactosaminyl)threonine + RESID-alternate + + + OGalNAcThr + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 12 H 20 N 2 O 7 + + + + MassAvg + 304.30 + + + + MassMono + 304.127051 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00563 + MOD:01676 + PSI-MOD + + + MOD:00165 + 1'-mannosyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan. + + 1482345 + PubMed + + + 16150691 + PubMed + + + AA0156 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 1'-glycosyl-L-tryptophan + RESID-alternate + + + 1'-mannosyl-L-tryptophan + RESID-name + + + CARBOHYD N-linked (Man) + UniProt-feature + + + N-mannosyl-tryptophan + RESID-alternate + + + N1'ManTrp + PSI-MOD-label + + + N1-mannosyl-tryptophan + RESID-alternate + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 17 H 20 N 2 O 6 + + + + MassAvg + 348.36 + + + + MassMono + 348.132136 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00006 + MOD:00595 + MOD:00761 + MOD:00918 + PSI-MOD + + + MOD:00166 + O4'-glucosyl-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine. + + 15279557 + PubMed + + + 3181138 + PubMed + + + AA0157 + RESID + + + 41#Y + UniMod + + + + (2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid + RESID-systematic + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + O4'-glucosyl-L-tyrosine + RESID-name + + + O4'-glycosyl-L-tyrosine + RESID-alternate + + + O4GlcTyr + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 15 H 19 N 1 O 7 + + + + MassAvg + 325.32 + + + + MassMono + 325.116152 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00433 + MOD:00761 + MOD:01927 + PSI-MOD + + + MOD:00167 + N-asparaginyl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine. + + 1824714 + PubMed + + + 8276756 + PubMed + + + AA0158 + RESID + + + + GPIAsn + PSI-MOD-label + + + LIPID GPI-anchor amidated asparagine + UniProt-feature + + + N-asparaginyl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 6 H 13 N 3 O 6 P 1 + + + + MassAvg + 254.16 + + + + MassMono + 254.054197 + + + + Origin + N + + + + Source + natural + + + + TermSpec + C-term + + MOD:00818 + MOD:00903 + PSI-MOD + + + MOD:00168 + N-aspartyl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine. + + 7120400 + PubMed + + + AA0159 + RESID + + + + GPIAsp + PSI-MOD-label + + + LIPID GPI-anchor amidated aspartate + UniProt-feature + + + N-aspartyl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 6 H 12 N 2 O 7 P 1 + + + + MassAvg + 255.14 + + + + MassMono + 255.038212 + + + + Origin + D + + + + Source + natural + + + + TermSpec + C-term + + MOD:00818 + MOD:00904 + PSI-MOD + + + MOD:00169 + N-cysteinyl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine. + + 2897081 + PubMed + + + AA0160 + RESID + + + + GPICys + PSI-MOD-label + + + LIPID GPI-anchor amidated cysteine + UniProt-feature + + + N-cysteinyl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 S 0 + + + + DiffMono + 123.008530 + + + + Formula + C 5 H 12 N 2 O 5 P 1 S 1 + + + + MassAvg + 243.19 + + + + MassMono + 243.020454 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:00818 + MOD:00905 + PSI-MOD + + + MOD:00170 + N-glycyl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine. + + 2341397 + PubMed + + + AA0161 + RESID + + + + GPIGly + PSI-MOD-label + + + LIPID GPI-anchor amidated glycine + UniProt-feature + + + N-glycyl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 4 H 10 N 2 O 5 P 1 + + + + MassAvg + 197.11 + + + + MassMono + 197.032733 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:00818 + MOD:00908 + PSI-MOD + + + MOD:00171 + N-seryl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine. + + 2111324 + PubMed + + + 8448158 + PubMed + + + AA0162 + RESID + + + + GPISer + PSI-MOD-label + + + LIPID GPI-anchor amidated serine + UniProt-feature + + + N-seryl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 5 H 12 N 2 O 6 P 1 + + + + MassAvg + 227.13 + + + + MassMono + 227.043298 + + + + Origin + S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00818 + MOD:00916 + PSI-MOD + + + MOD:00172 + N-alanyl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine. + + 7682556 + PubMed + + + 7744038 + PubMed + + + AA0163 + RESID + + + + GPIAla + PSI-MOD-label + + + LIPID GPI-anchor amidated alanine + UniProt-feature + + + N-alanyl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 5 H 12 N 2 O 5 P 1 + + + + MassAvg + 211.13 + + + + MassMono + 211.048383 + + + + Origin + A + + + + Source + natural + + + + TermSpec + C-term + + MOD:00818 + MOD:00901 + PSI-MOD + + + MOD:00173 + N-threonyl-glycosylphosphatidylinositolethanolamine + + A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine. + + AA0164 + RESID + + + + GPIThr + PSI-MOD-label + + + LIPID GPI-anchor amidated threonine + UniProt-feature + + + N-threonyl-glycosylphosphatidylinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 6 H 14 N 2 O 6 P 1 + + + + MassAvg + 241.16 + + + + MassMono + 241.058948 + + + + Origin + T + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00818 + MOD:00917 + PSI-MOD + + + MOD:00174 + N-glycyl-glycosylsphingolipidinositolethanolamine + + A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine. + + 12626404 + PubMed + + + 8404891 + PubMed + + + AA0165 + RESID + + + + GSIGly + PSI-MOD-label + + + LIPID GPI-like-anchor amidated glycine + UniProt-feature + + + N-glycyl-glycosylsphingolipidinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 4 H 10 N 2 O 5 P 1 + + + + MassAvg + 197.11 + + + + MassMono + 197.032733 + + + + Origin + G + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00466 + MOD:00908 + PSI-MOD + + + MOD:00175 + N-seryl-glycosylsphingolipidinositolethanolamine + + A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine. + + 12626404 + PubMed + + + 2721485 + PubMed + + + 8269952 + PubMed + + + AA0166 + RESID + + + + GSISer + PSI-MOD-label + + + LIPID GPI-like-anchor amidated serine + UniProt-feature + + + N-seryl-glycosylsphingolipidinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 5 H 12 N 2 O 6 P 1 + + + + MassAvg + 227.13 + + + + MassMono + 227.043298 + + + + Origin + S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00466 + MOD:00916 + PSI-MOD + + + MOD:00176 + O-(phosphoribosyl dephospho-coenzyme A)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine. + + 10924139 + PubMed + + + 11052675 + PubMed + + + 179809 + PubMed + + + 180526 + PubMed + + + 368065 + PubMed + + + AA0167 + RESID + + + 395#S + UniMod + + + pRibodePcoA + PSI-MOD-slim + + MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine + UniProt-feature + + + O-(phosphoribosyl dephospho-coenzyme A)-L-serine + RESID-name + + + O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine + RESID-alternate + + + O3-(phosphoribosyl dephospho-coenzyme A)-L-serine + RESID-alternate + + + O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine + RESID-alternate + + + OPRibdPCoASer + PSI-MOD-label + + + phosphoribosyl dephospho-coenzyme A + UniMod-description + + + PhosphoribosyldephosphoCoA + PSI-MS-label + + + + DiffAvg + 881.63 + + + + DiffFormula + C 26 H 42 N 7 O 19 P 3 S 1 + + + + DiffMono + 881.146903 + + + + Formula + C 29 H 47 N 8 O 21 P 3 S 1 + + + + MassAvg + 968.71 + + + + MassMono + 968.178931 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00860 + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:00177 + omega-N-(ADP-ribosyl)-L-arginine + + A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine. + + 0 + DeltaMass + + + 15842200 + PubMed + + + 209022 + PubMed + + + 3090031 + PubMed + + + 3923473 + PubMed + + + 6582062 + PubMed + + + AA0168 + RESID + + + 213#R + UniMod + + + From DeltaMass: Average Mass: 541. + PSI-MOD-slim + + (S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid + RESID-systematic + + + ADP Ribose addition + UniMod-description + + + ADP-Ribosyl + PSI-MS-label + + + ADPRibArg + PSI-MOD-label + + + MOD_RES ADP-ribosylarginine + UniProt-feature + + + N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine + RESID-alternate + + + N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + N-(ADP-ribosyl)- (on Arginine) + DeltaMass-label + + + omega-N-(ADP-ribosyl)-L-arginine + RESID-name + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 21 H 33 N 9 O 14 P 2 + + + + MassAvg + 697.49 + + + + MassMono + 697.162220 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00902 + PSI-MOD + + + MOD:00178 + S-(ADP-ribosyl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine. + + 0 + DeltaMass + + + 15842200 + PubMed + + + 3863818 + PubMed + + + AA0169 + RESID + + + 213#C + UniMod + + + From DeltaMass: Average Mass: 541. + PSI-MOD-slim + + (R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid + RESID-systematic + + + ADP Ribose addition + UniMod-description + + + ADP-Ribosyl + PSI-MS-label + + + ADPRibCys + PSI-MOD-label + + + MOD_RES ADP-ribosylcysteine + UniProt-feature + + + S-(ADP-ribosyl)- (on Cysteine) + DeltaMass-label + + + S-(ADP-ribosyl)-L-cysteine + RESID-name + + + S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 S 0 + + + + DiffMono + 541.061109 + + + + Formula + C 18 H 26 N 6 O 14 P 2 S 1 + + + + MassAvg + 644.44 + + + + MassMono + 644.070294 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00905 + PSI-MOD + + + MOD:00179 + L-glutamyl 5-glycerylphosphorylethanolamine + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine. + + 2511205 + PubMed + + + 2569467 + PubMed + + + 9662537 + PubMed + + + AA0170 + RESID + + + 396#E + UniMod + + + glycerylPE + PSI-MOD-slim + + (S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid + RESID-systematic + + + 5-L-glutamyl glycerylphosphorylethanolamine + RESID-name + + + 5GlyceroPEtAGlu + PSI-MOD-label + + + GlycerylPE + PSI-MS-label + + + glycerylphosphorylethanolamine + UniMod-description + + + L-glutamyl 5-glycerophosphoethanolamine + RESID-alternate + + + L-glutamyl 5-glycerophosphorylethanolamine + RESID-alternate + + + L-glutamyl 5-glycerylphosphorylethanolamine + RESID-alternate + + + MOD_RES 5-glutamyl glycerylphosphorylethanolamine + UniProt-feature + + + + DiffAvg + 197.13 + + + + DiffFormula + C 5 H 12 N 1 O 5 P 1 + + + + DiffMono + 197.045309 + + + + Formula + C 10 H 19 N 2 O 8 P 1 + + + + MassAvg + 326.24 + + + + MassMono + 326.087902 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + PSI-MOD + + + MOD:00180 + S-sulfo-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine. + + 12876326 + PubMed + + + 14752058 + PubMed + + + 643076 + PubMed + + + AA0171 + RESID + + + 40#C + UniMod + + + + (2R)-2-amino-3-(sulfosulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(sulfothio)propanoic acid + RESID-alternate + + + 3-(sulfosulfanyl)-L-alanine + RESID-alternate + + + cysteine sulfate thioester + RESID-alternate + + + cysteine-S-sulfonic acid + RESID-alternate + + + O-Sulfonation + UniMod-description + + + S-sulfo-L-cysteine + RESID-name + + + S-sulfocysteine + PSI-MOD-alternate + + + S-sulfocysteine + RESID-alternate + + + SSulfCys + PSI-MOD-label + + + Sulfo + PSI-MS-label + + + + DiffAvg + 80.06 + + + + DiffFormula + C 0 H 0 N 0 O 3 S 1 + + + + DiffMono + 79.956815 + + + + Formula + C 3 H 5 N 1 O 4 S 2 + + + + MassAvg + 183.20 + + + + MassMono + 182.966000 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00695 + MOD:00777 + MOD:00905 + PSI-MOD + + + MOD:00181 + O4'-sulfo-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine. + + 88 + DeltaMass + + + 10226369 + PubMed + + + 14752058 + PubMed + + + 2303439 + PubMed + + + 3778455 + PubMed + + + 3801003 + PubMed + + + AA0172 + RESID + + + 40#Y + UniMod + + + From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161. + PSI-MOD-slim + + (S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid + RESID-systematic + + + 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate + RESID-alternate + + + MOD_RES Sulfotyrosine + UniProt-feature + + + O-Sulfonation + UniMod-description + + + O4'-sulfo-L-tyrosine + RESID-name + + + O4-sulfotyrosine + RESID-alternate + + + OSulfTyr + PSI-MOD-label + + + sulfationy + OMSSA-label + + + Sulfo + PSI-MS-label + + + Sulphation (of O of Tyrosine) + DeltaMass-label + + + tyrosine sulfate + RESID-alternate + + + tyrosine-O-sulfonic acid + RESID-alternate + + + tyrosine-O-sulphonic acid + RESID-alternate + + + Tyrosinyl Sulphate + DeltaMass-label + + + + DiffAvg + 80.06 + + + + DiffFormula + C 0 H 0 N 0 O 3 S 1 + + + + DiffMono + 79.956815 + + + + Formula + C 9 H 9 N 1 O 5 S 1 + + + + MassAvg + 243.23 + + + + MassMono + 243.020143 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00695 + MOD:00774 + MOD:00919 + PSI-MOD + + + MOD:00182 + L-bromohistidine + + A protein modification that effectively converts an L-histidine residue to L-bromohistidine. + + 2076468 + PubMed + + + 9033387 + PubMed + + + AA0173 + RESID + + + 340#H + UniMod + + + + Br1His + PSI-MOD-label + + + bromination + UniMod-description + + + Bromo + PSI-MS-label + + + L-bromohistidine + RESID-name + + + MOD_RES Bromohistidine + UniProt-feature + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 6 H 6 N 3 O 1 + + + + MassAvg + 216.04 + + + + MassMono + 214.969424 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:01049 + MOD:01912 + PSI-MOD + + + MOD:00183 + L-2'-bromophenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine. + + 83 + DeltaMass + + + 2059627 + PubMed + + + 2076468 + PubMed + + + 9033387 + PubMed + + + AA0174 + RESID + + + From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa. + + (S)-2-amino-3-(2-bromophenyl)propanoic acid + RESID-systematic + + + 2'BrPhe + PSI-MOD-label + + + bromination + UniMod-description + + + Bromo + PSI-MS-label + + + L-2'-bromophenylalanine + RESID-name + + + L-o-bromination of Phe with 79Br + DeltaMass-label + + + o-bromophenylalanine + RESID-alternate + + + ortho-bromophenylalanine + RESID-alternate + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 9 H 8 N 1 O 1 + + + + MassAvg + 226.07 + + + + MassMono + 224.978926 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00972 + PSI-MOD + + + MOD:00184 + L-3'-bromophenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine. + + 2076468 + PubMed + + + 9033387 + PubMed + + + AA0175 + RESID + + + + (S)-2-amino-3-(3-bromophenyl)propanoic acid + RESID-systematic + + + 3'BrPhe + PSI-MOD-label + + + bromination + UniMod-description + + + Bromo + PSI-MS-label + + + L-3'-bromophenylalanine + RESID-name + + + m-bromophenylalanine + RESID-alternate + + + meta-bromophenylalanine + RESID-alternate + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 9 H 8 N 1 O 1 + + + + MassAvg + 226.07 + + + + MassMono + 224.978926 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00972 + PSI-MOD + + + MOD:00185 + L-4'-bromophenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine. + + 2076468 + PubMed + + + 9033387 + PubMed + + + AA0176 + RESID + + + + (2S)-2-amino-3-(4-bromophenyl)propanoic acid + RESID-systematic + + + 4'BrPhe + PSI-MOD-label + + + bromination + UniMod-description + + + Bromo + PSI-MS-label + + + L-4'-bromophenylalanine + RESID-name + + + p-bromophenylalanine + RESID-alternate + + + para-bromophenylalanine + RESID-alternate + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 9 H 8 N 1 O 1 + + + + MassAvg + 226.07 + + + + MassMono + 224.978926 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00972 + PSI-MOD + + + MOD:00186 + 3',3'',5'-triiodo-L-thyronine + + A protein modification that effectively substitutes an L-tyrosine residue with 3',3'',5'-triiodo-L-thyronine. + + 18258 + ChEBI + + + 0 + DeltaMass + + + AA0177 + RESID + + + 397 + UniMod + + + From DeltaMass: Average Mass: 470. + PSI-MOD-slim + + (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid + RESID-systematic + + + 3',3'',5'-triiodo-L-thyronine + RESID-name + + + 3,3',5-triiodo-L-thyronine + RESID-alternate + + + 3,5,3'-triiodo-L-thyronine + RESID-alternate + + + 3,5,3'-Triiodothyronine (from Tyrosine) + DeltaMass-label + + + 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine + RESID-alternate + + + I3Thy + PSI-MOD-label + + + liothyronine + RESID-alternate + + + MOD_RES Triiodothyronine + UniProt-feature + + + O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine + RESID-alternate + + + T3 + RESID-alternate + + + triiodo + UniMod-description + + + Triiodothyronine + PSI-MS-label + + + + DiffAvg + 469.79 + + + + DiffFormula + C 6 H 1 I 3 N 0 O 1 + + + + DiffMono + 469.716158 + + + + Formula + C 15 H 10 I 3 N 1 O 3 + + + + MassAvg + 632.96 + + + + MassMono + 632.779486 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00502 + MOD:00998 + PSI-MOD + + + MOD:00187 + L-thyroxine + + A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine. + + 18332 + ChEBI + + + 6704086 + PubMed + + + AA0178 + RESID + + + 398 + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid + RESID-systematic + + + 3',3'',5',5''-tetraiodo-L-thyronine + RESID-alternate + + + 3,3',5,5'-tetraiodo-L-thyronine + RESID-alternate + + + 3,5,3',5'-tetraiodo-L-thyronine + RESID-alternate + + + 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine + RESID-alternate + + + I4Thy + PSI-MOD-label + + + L-thyroxine + RESID-name + + + MOD_RES Thyroxine + UniProt-feature + + + O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine + RESID-alternate + + + T4 + RESID-alternate + + + tetraiodo + UniMod-description + + + Thyroxine + PSI-MS-label + + + + DiffAvg + 595.68 + + + + DiffFormula + C 6 H 0 I 4 N 0 O 1 + + + + DiffMono + 595.612805 + + + + Formula + C 15 H 9 I 4 N 1 O 3 + + + + MassAvg + 758.86 + + + + MassMono + 758.676134 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00998 + PSI-MOD + + + MOD:00188 + 6'-bromo-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan. + + 12118011 + PubMed + + + 9030520 + PubMed + + + 9033387 + PubMed + + + 9434739 + PubMed + + + AA0179 + RESID + + + 340#W + UniMod + + + + (2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 6'-bromo-L-tryptophan + RESID-name + + + 6'-BrTrp + PSI-MOD-label + + + bromination + UniMod-description + + + Bromo + PSI-MS-label + + + MOD_RES 6'-bromotryptophan + UniProt-feature + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 11 H 9 N 2 O 1 + + + + MassAvg + 265.11 + + + + MassMono + 263.989825 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:01068 + MOD:01912 + PSI-MOD + + + MOD:00189 + dehydroalanine (Ser) + + A protein modification that effectively converts an L-serine residue to dehydroalanine. + + 0 + DeltaMass + + + 10220322 + PubMed + + + 1547888 + PubMed + + + 1815586 + PubMed + + + 2914619 + PubMed + + + 7947813 + PubMed + + + 8239649 + PubMed + + + AA0181#SER + RESID + + + 23#S + UniMod + + + PSI-MOD-slim + + 2,3-didehydroalanine + RESID-alternate + + + 2-aminoacrylic acid + RESID-alternate + + + 2-aminopropenoic acid + RESID-systematic + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + anhydroserine + RESID-alternate + + + beta-elim-s + OMSSA-label + + + Dehydrated + PSI-MS-label + + + dehydro + OMSSA-label + + + dehydroalanine + RESID-name + + + Dha + RESID-alternate + + + Dha(Ser) + PSI-MOD-label + + + MOD_RES 2,3-didehydroalanine (Ser) + UniProt-feature + + + phospholosss + OMSSA-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 3 H 3 N 1 O 1 + + + + MassAvg + 69.06 + + + + MassMono + 69.021464 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00416 + MOD:00916 + MOD:01168 + PSI-MOD + + + MOD:00190 + dehydrobutyrine (Thr) + + A protein modification that effectively converts an L-threonine residue to dehydrobutyrine. + + 0 + DeltaMass + + + 1547888 + PubMed + + + 3769923 + PubMed + + + AA0182 + RESID + + + 23#T + UniMod + + + PSI-MOD-slim + + (2Z)-2-aminobut-2-enoic acid + RESID-systematic + + + (Z)-2-amino-2-butenoic acid + RESID-alternate + + + (Z)-2-aminobutenoic acid + RESID-alternate + + + (Z)-dehydrobutyrine + RESID-name + + + 2,3-didehydrobutyrine + RESID-alternate + + + 3-methyldehydroalanine + RESID-alternate + + + alpha,beta-dehydroaminobutyric acid + RESID-alternate + + + anhydrothreonine + RESID-alternate + + + beta-elim-t + OMSSA-label + + + Dehydrated + PSI-MS-label + + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + dehydro + OMSSA-label + + + Dehydroamino butyric acid + DeltaMass-label + + + Dhb + RESID-alternate + + + Dhb(Thr) + PSI-MOD-label + + + methyl-dehydroalanine + RESID-alternate + + + MOD_RES (Z)-2,3-didehydrobutyrine + UniProt-feature + + + phospholosst + OMSSA-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00416 + MOD:00917 + MOD:01703 + PSI-MOD + + + MOD:00191 + (Z)-2,3-didehydrotyrosine + + A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine. + + 1347277 + PubMed + + + 9631087 + PubMed + + + AA0183 + RESID + + + incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 + PSI-MOD-slim + + (2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid + RESID-systematic + + + (Z)-2,3-didehydrogenated tyrosine + PSI-MOD-alternate + + + (Z)-2,3-didehydrotyrosine + RESID-name + + + 2-amino-3-oxo-butanoic_acid + UniMod-description + + + amino-(para-hydroxybenzylidenyl)acetic acid + RESID-alternate + + + cis-dehydrotyrosine + RESID-alternate + + + Didehydro + PSI-MS-label + + + green fluorescent protein chromophore + RESID-alternate + + + MOD_RES (Z)-2,3-didehydrotyrosine + UniProt-feature + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + red fluorescent protein chromophore + RESID-alternate + + + Z-dHTyr + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 9 H 7 N 1 O 2 + + + + MassAvg + 161.16 + + + + MassMono + 161.047678 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00706 + PSI-MOD + + + MOD:00192 + L-serine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine. + + 21393 + ChEBI + + + 1347277 + PubMed + + + 9631087 + PubMed + + + AA0184 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. + + (2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + CROSSLNK 5-imidazolinone (Ser-Gly) + UniProt-feature + + + green fluorescent protein chromophore + RESID-alternate + + + L-serine 5-imidazolinone glycine + RESID-name + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + seryl-5-imidazolinone glycine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 6 N 2 O 2 + + + + MassAvg + 126.11 + + + + MassMono + 126.042927 + + + + Origin + G, S + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:00916 + MOD:01882 + PSI-MOD + + + MOD:00193 + L-3-oxoalanine (Cys) + + A protein modification that effectively converts an L-cysteine residue to L-oxoalanine. + + 350 + DeltaMass + + + 14563551 + PubMed + + + 7628016 + PubMed + + + 8681943 + PubMed + + + 9478923 + PubMed + + + AA0185#CYS + RESID + + + 402#C + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-oxopropanoic acid + RESID-systematic + + + 2-amino-3-oxopropionic acid + RESID-alternate + + + C(alpha)-formylglycine + RESID-misnomer + + + L-3-oxoalanine + RESID-name + + + L-amino-malonic acid semialdehyde + RESID-alternate + + + L-aminomalonaldehydic acid + RESID-alternate + + + L-serinesemialdehyde + RESID-misnomer + + + MOD_RES 3-oxoalanine (Cys) + UniProt-feature + + + Oxala(Cys) + PSI-MOD-label + + + + DiffAvg + -18.08 + + + + DiffFormula + C 0 H -2 N 0 O 1 S -1 + + + + DiffMono + -17.992806 + + + + Formula + C 3 H 3 N 1 O 2 + + + + MassAvg + 85.06 + + + + MassMono + 85.016378 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:01169 + PSI-MOD + + + MOD:00194 + lactic acid + + A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid. + + 7607233 + PubMed + + + AA0186 + RESID + + + 403#S + UniMod + + + + (2R)-2-hydroxypropanoic acid + RESID-systematic + + + 2-hydroxypropionic acid + RESID-alternate + + + alpha-hydroxypropionic acid + RESID-alternate + + + Lac(Ser) + PSI-MOD-label + + + lactic acid + RESID-name + + + lactic acid from N-term Ser + UniMod-description + + + MOD_RES Lactic acid + UniProt-feature + + + Ser->LacticAcid + PSI-MS-label + + + + DiffAvg + -15.02 + + + + DiffFormula + C 0 H -1 N -1 O 0 + + + + DiffMono + -15.010899 + + + + Formula + C 3 H 5 O 2 + + + + MassAvg + 73.07 + + + + MassMono + 73.028954 + + + + Origin + S + + + + TermSpec + N-term + + MOD:00916 + PSI-MOD + + + MOD:00195 + L-alanine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine. + + 10220322 + PubMed + + + AA0187 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. + + (2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 4-methylidene-imidazole-5-one active site + RESID-alternate + + + alanyl-5-imidazolinone glycine + RESID-alternate + + + CROSSLNK 5-imidazolinone (Ala-Gly) + UniProt-feature + + + L-alanine 5-imidazolinone glycine + RESID-name + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + XLNK-1Ala-NGly(Imidazole) + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 6 N 2 O 1 + + + + MassAvg + 110.12 + + + + MassMono + 110.048013 + + + + Origin + A, G + + + + Source + natural + + + + TermSpec + none + + MOD:00901 + MOD:00908 + MOD:01882 + PSI-MOD + + + MOD:00196 + L-cysteine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine. + + 1537807 + PubMed + + + AA0188 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. + + (2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + CROSSLNK 5-imidazolinone (Cys-Gly) + UniProt-feature + + + cysteinyl-5-imidazolinone glycine + RESID-alternate + + + L-cysteine 5-imidazolinone glycine + RESID-name + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + XLNK-1Cys-NGly(Imidazole) + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 6 N 2 O 1 S 1 + + + + MassAvg + 142.18 + + + + MassMono + 142.020084 + + + + Origin + C, G + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:00908 + MOD:01882 + PSI-MOD + + + MOD:00197 + 2-imino-glutamine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine. + + 11050230 + PubMed + + + 11209050 + PubMed + + + AA0189 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. + + 2,N-didehydroglutaminyl-5-imidazolinone glycine + RESID-alternate + + + 2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 2-imino-glutamine 5-imidazolinone glycine + RESID-name + + + [2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid + RESID-alternate + + + [2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid + RESID-systematic + + + CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly) + UniProt-feature + + + fluorescent protein FP583 chromophore + RESID-alternate + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + red fluorescent protein chromophore + RESID-alternate + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 7 N 3 O 2 + + + + MassAvg + 165.15 + + + + MassMono + 165.053826 + + + + Origin + G, Q + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + MOD:00908 + MOD:01882 + PSI-MOD + + + MOD:00198 + D-alanine (Ala) + + A protein modification that effectively converts an L-alanine residue to D-alanine. + + 15023056 + PubMed + + + 7287302 + PubMed + + + 7961627 + PubMed + + + AA0191#ALA + RESID + + + + (R)-2-aminopropanoic acid + RESID-systematic + + + D-Ala(Ala) + PSI-MOD-label + + + D-alanine + RESID-name + + + MOD_RES D-alanine (Ala) + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + A + + + + Source + natural + + + + TermSpec + none + + MOD:00570 + MOD:00862 + MOD:00901 + PSI-MOD + + + MOD:00199 + D-allo-isoleucine + + A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine. + + 30007 + ChEBI + + + 8223491 + PubMed + + + AA0192 + RESID + + + + (2R,3S)-2-amino-3-methylpentanoic acid + RESID-systematic + + + 2-azanyl-3-methylpentanoic acid + RESID-alternate + + + 3-methyl-norvaline + RESID-alternate + + + allo-D-isoleucine + RESID-alternate + + + alpha-amino-beta-methylvaleric acid + RESID-alternate + + + D-allo-isoleucine + RESID-name + + + D-Ile + PSI-MOD-label + + + D-threo-isoleucine + RESID-alternate + + + MOD_RES D-allo-isoleucine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00306 + MOD:00664 + MOD:00910 + PSI-MOD + + + MOD:00200 + D-methionine + + A protein modification that effectively converts an L-methionine residue to D-methionine. + + 29984 + ChEBI + + + 16033333 + PubMed + + + 2542051 + PubMed + + + AA0193 + RESID + + + + (2R)-2-amino-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-amino-4-(methylthio)butanoic acid + RESID-alternate + + + 2-amino-4-(methylthio)butyric acid + RESID-alternate + + + D-Met + PSI-MOD-label + + + D-methionine + RESID-name + + + MOD_RES D-methionine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 S 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 131.19 + + + + MassMono + 131.040485 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00913 + PSI-MOD + + + MOD:00201 + D-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine. + + 29996 + ChEBI + + + 1548227 + PubMed + + + 1644179 + PubMed + + + 2597281 + PubMed + + + AA0194 + RESID + + + + (R)-2-amino-3-phenylpropanoic acid + RESID-systematic + + + D-Phe + PSI-MOD-label + + + D-phenylalanine + RESID-name + + + MOD_RES D-phenylalanine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 9 H 9 N 1 O 1 + + + + MassAvg + 147.18 + + + + MassMono + 147.068414 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00914 + PSI-MOD + + + MOD:00202 + D-serine (Ser) + + A protein modification that effectively converts an L-serine residue to D-serine. + + 7973665 + PubMed + + + AA0195#SER + RESID + + + + (R)-2-amino-3-hydroxypropanoic acid + RESID-systematic + + + D-Ser(Ser) + PSI-MOD-label + + + D-serine + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 3 H 5 N 1 O 2 + + + + MassAvg + 87.08 + + + + MassMono + 87.032028 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00891 + MOD:00916 + PSI-MOD + + + MOD:00203 + D-asparagine + + A protein modification that effectively converts an L-asparagine residue to D-asparagine. + + 29957 + ChEBI + + + 1859408 + PubMed + + + AA0196 + RESID + + + + (R)-2-amino-4-butanediamic acid + RESID-systematic + + + D-alpha-aminosuccinamic acid + RESID-alternate + + + D-Asn + PSI-MOD-label + + + D-asparagine + RESID-name + + + D-aspartic acid beta-amide + RESID-alternate + + + MOD_RES D-asparagine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 4 H 6 N 2 O 2 + + + + MassAvg + 114.10 + + + + MassMono + 114.042927 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00903 + PSI-MOD + + + MOD:00204 + D-leucine + + A protein modification that effectively converts an L-leucine residue to D-leucine. + + 30005 + ChEBI + + + 10461743 + PubMed + + + 12135762 + PubMed + + + 1358533 + PubMed + + + 1548227 + PubMed + + + AA0197 + RESID + + + + (2R)-2-amino-4-methylpentanoic acid + RESID-systematic + + + alpha-aminoisocaproic acid + RESID-alternate + + + D-Leu + PSI-MOD-label + + + D-leucine + RESID-name + + + MOD_RES D-leucine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:00306 + MOD:00664 + MOD:00911 + PSI-MOD + + + MOD:00205 + D-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to D-tryptophan. + + 29955 + ChEBI + + + 8910408 + PubMed + + + AA0198 + RESID + + + + (R)-2-amino-3-(1H-indol-3-yl)propanoic acid + RESID-systematic + + + alpha-amino-beta-(3-indolyl)propionoic acid + RESID-alternate + + + D-Trp + PSI-MOD-label + + + D-tryptophan + RESID-name + + + MOD_RES D-tryptophan + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 11 H 10 N 2 O 1 + + + + MassAvg + 186.21 + + + + MassMono + 186.079313 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00918 + PSI-MOD + + + MOD:00206 + L-isoglutamyl-polyglycine + + A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine. + + 21343 + ChEBI + + + 10074368 + PubMed + + + 16368691 + PubMed + + + 7992051 + PubMed + + + AA0201 + RESID + + + + gamma-glutamylpolyglycine + RESID-alternate + + + L-isoglutamyl-polyglycine + RESID-name + + + MOD_RES 5-glutamyl polyglycine + UniProt-feature + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + C 7 H 10 N 2 O 4 + + + + MassAvg + 186.17 + + + + MassMono + 186.064057 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + PSI-MOD + + + MOD:00207 + L-isoglutamyl-polyglutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid. + + 10747868 + PubMed + + + 1680872 + PubMed + + + AA0202 + RESID + + + + gamma-glutamylpolyglutamic acid + RESID-alternate + + + L-isoglutamyl-polyglutamic acid + RESID-name + + + + DiffAvg + 129.12 + + + + DiffFormula + C 5 H 7 N 1 O 3 + + + + DiffMono + 129.042593 + + + + Formula + C 10 H 14 N 2 O 6 + + + + MassAvg + 258.23 + + + + MassMono + 258.085186 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00674 + MOD:00906 + PSI-MOD + + + MOD:00208 + O4'-(phospho-5'-adenosine)-L-tyrosine + + A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine. + + 0 + DeltaMass + + + 5543675 + PubMed + + + AA0203 + RESID + + + 405#Y + UniMod + + + From DeltaMass: Average Mass: 329. + PSI-MOD-slim + + (2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid + RESID-systematic + + + 5'-adenylic-O-tyrosine + RESID-alternate + + + AMP binding site + UniMod-description + + + hydrogen 5'-adenylate tyrosine ester + RESID-alternate + + + MOD_RES O-AMP-tyrosine + UniProt-feature + + + O-5'-Adenosylation ( of Tyrosine) + DeltaMass-label + + + O4'-(phospho-5'-adenosine)-L-tyrosine + RESID-name + + + O4'-L-tyrosine 5'-adenosine phosphodiester + RESID-alternate + + + OAMPTyr + PSI-MOD-label + + + Phosphoadenosine + PSI-MS-label + + + + DiffAvg + 329.21 + + + + DiffFormula + C 10 H 12 N 5 O 6 P 1 + + + + DiffMono + 329.052520 + + + + Formula + C 19 H 21 N 6 O 8 P 1 + + + + MassAvg + 492.38 + + + + MassMono + 492.115848 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00919 + MOD:01165 + PSI-MOD + + + MOD:00209 + S-(2-aminovinyl)-D-cysteine (Cys-Ser) + + A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. + + 3181159 + PubMed + + + 3769923 + PubMed + + + AA0204#SER + RESID + + + Cross-link 2. + + (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid + RESID-systematic + + + (S,Z)-S-(2-aminovinyl)cysteine + RESID-alternate + + + CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys) + UniProt-feature + + + S-(2-aminovinyl)-D-cysteine + RESID-name + + + XLNK-(D)SCys-VinAm + PSI-MOD-label + + + + DiffAvg + -64.04 + + + + DiffFormula + C -1 H -4 N 0 O -3 S 0 + + + + DiffMono + -64.016044 + + + + Formula + C 5 H 7 N 2 O 1 S 1 + + + + MassAvg + 143.18 + + + + MassMono + 143.027909 + + + + Origin + C, S + + + + TermSpec + C-term + + MOD:00916 + MOD:01850 + PSI-MOD + + + MOD:00210 + L-cysteine sulfenic acid + + A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid. + + 41 + DeltaMass + + + 10964927 + PubMed + + + 2501303 + PubMed + + + 8756456 + PubMed + + + 9214307 + PubMed + + + 9586994 + PubMed + + + 9587003 + PubMed + + + AA0205 + RESID + + + 35#C + UniMod + + + From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH). + PSI-MOD-slim + + (2R)-2-amino-3-(hydroxysulfanyl)propanoic acid + RESID-systematic + + + (2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer] + RESID-alternate + + + 2-amino-2-carboxyethanesulfenic acid + RESID-alternate + + + 2-amino-3-sulfinylpropanoic acid [tautomer] + RESID-alternate + + + 3-sulfenoalanine + RESID-alternate + + + ACT_SITE Cysteine sulfenic acid (-SOH) intermediate + UniProt-feature + + + CysOH + PSI-MOD-label + + + cysteine S-oxide [tautomer] + RESID-alternate + + + cysteine sulfoxide [tautomer] + RESID-alternate + + + cysteine sulphenic acid + RESID-alternate + + + L-cysteine sulfenic acid + RESID-name + + + mod193 + OMSSA-label + + + MOD_RES Cysteine sulfenic acid (-SOH) + UniProt-feature + + + Oxidation + PSI-MS-label + + + S-hydroxycysteine + RESID-alternate + + + S-oxocysteine [tautomer] + RESID-alternate + + + S-oxycysteine [tautomer] + RESID-alternate + + + Sulfenic Acid (from Cysteine) + DeltaMass-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 S 0 + + + + DiffMono + 15.994915 + + + + Formula + C 3 H 5 N 1 O 2 S 1 + + + + MassAvg + 119.14 + + + + MassMono + 119.004099 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00708 + MOD:01854 + PSI-MOD + + + MOD:00211 + S-(glycyl)-L-cysteine (Cys-Gly) + + A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine. + + 22050 + ChEBI + + + 3306404 + PubMed + + + AA0206 + RESID + + + Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cycteine see MOD:01777 [JSG]. + PSI-MOD-slim + + (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid + RESID-systematic + + + 1-(cystein-S-yl)-glycinate + RESID-alternate + + + ACT_SITE Glycyl thioester intermediate + UniProt-feature + + + glycine cysteine thioester + RESID-alternate + + + S-(2-amino-1-oxoethyl)cysteine + RESID-alternate + + + S-(glycyl)-L-cysteine + RESID-name + + + XLNK-SCys-1Gly + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 7 N 2 O 2 S 1 + + + + MassAvg + 159.18 + + + + MassMono + 159.022823 + + + + Origin + C, G + + + + TermSpec + C-term + + MOD:00395 + MOD:00908 + MOD:00954 + PSI-MOD + + + MOD:00212 + S-4-hydroxycinnamyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine. + + 7947803 + PubMed + + + 7981196 + PubMed + + + AA0207 + RESID + + + 407 + UniMod + + + + (2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid + RESID-systematic + + + cinnamate cysteine thioester + RESID-alternate + + + Hydroxycinnamyl + PSI-MS-label + + + hydroxycinnamyl + UniMod-description + + + MOD_RES S-(4-hydroxycinnamyl)cysteine + UniProt-feature + + + S-4-hydroxycinnamyl-L-cysteine + RESID-name + + + S-para-coumaryl-L-cysteine + RESID-alternate + + + + DiffAvg + 146.14 + + + + DiffFormula + C 9 H 6 N 0 O 2 S 0 + + + + DiffMono + 146.036779 + + + + Formula + C 12 H 11 N 1 O 3 S 1 + + + + MassAvg + 249.28 + + + + MassMono + 249.045964 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00213 + chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine + + A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. + + 1794445 + PubMed + + + 1898736 + PubMed + + + 3472204 + PubMed + + + AA0208 + RESID + + + + chondroitin 4-sulfate (chondroitin sulfate A) + RESID-alternate + + + chondroitin 6-sulfate (chondroitin sulfate C) + RESID-alternate + + + chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine + RESID-name + + + poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine + RESID-systematic + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007825 + + + + Formula + C 3 H 4 N 1 O 2 + + + + MassAvg + 86.07 + + + + MassMono + 86.024203 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:00214 + dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine + + A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. + + 2914936 + PubMed + + + 3472204 + PubMed + + + AA0209 + RESID + + + + beta-heparin + RESID-alternate + + + chondroitin sulfate B + RESID-alternate + + + dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine + RESID-name + + + poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine + RESID-systematic + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007825 + + + + Formula + C 3 H 4 N 1 O 2 + + + + MassAvg + 86.07 + + + + MassMono + 86.024203 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:00215 + heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine + + A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. + + 3472204 + PubMed + + + AA0210 + RESID + + + + heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine + RESID-name + + + heparin + RESID-alternate + + + heparitin sulfate + RESID-alternate + + + poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine + RESID-systematic + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007825 + + + + Formula + C 3 H 4 N 1 O 2 + + + + MassAvg + 86.07 + + + + MassMono + 86.024203 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:00216 + N6-formyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine. + + 15799070 + PubMed + + + AA0211 + RESID + + + 122#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(formylamino)hexanoic acid + RESID-systematic + + + epsilon-formyllysine + RESID-alternate + + + Formyl + PSI-MS-label + + + Formylation + UniMod-description + + + formylk + OMSSA-label + + + MOD_RES N6-formyllysine + UniProt-feature + + + N(zeta)-formyllysine + RESID-alternate + + + N6-formyl-L-lysine + RESID-name + + + N6-formylated L-lysine + PSI-MOD-alternate + + + N6FoLys + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 7 H 12 N 2 O 2 + + + + MassAvg + 156.19 + + + + MassMono + 156.089878 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00409 + MOD:01875 + PSI-MOD + + + MOD:00217 + O4-arabinosyl-L-hydroxyproline + + A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline. + + 0 + DeltaMass + + + 666730 + PubMed + + + 7852316 + PubMed + + + AA0212 + RESID + + + 408 + UniMod + + + secondary to RESID:AA0030; From DeltaMass: Average Mass: 147. + PSI-MOD-slim + + (2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid + RESID-systematic + + + 4-(beta-L-arabinofuranosyloxy)proline + RESID-alternate + + + 4-Glycosyloxy- (pentosyl,C5) (of Proline) + DeltaMass-label + + + beta-arabinofuranosyl-4-hydroxyproline + RESID-alternate + + + Glycosyl + PSI-MS-label + + + glycosyl-L-hydroxyproline + UniMod-description + + + O4-arabinosyl-L-hydroxyproline + RESID-name + + + O4-glycosyl-hydroxyproline + RESID-alternate + + + OAra4HyPro + PSI-MOD-label + + + + DiffAvg + 148.11 + + + + DiffFormula + C 5 H 8 N 0 O 5 + + + + DiffMono + 148.037173 + + + + Formula + C 10 H 15 N 1 O 6 + + + + MassAvg + 245.23 + + + + MassMono + 245.089937 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00396 + MOD:00915 + PSI-MOD + + + MOD:00218 + O-(phospho-5'-RNA)-L-serine + + A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine. + + 1705009 + PubMed + + + AA0213 + RESID + + + + (S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid + RESID-systematic + + + MOD_RES O-(5'-phospho-RNA)-serine + UniProt-feature + + + O-(phospho-5'-RNA)-L-serine + RESID-name + + + O3-(phospho-5'-RNA)-L-serine + RESID-alternate + + + O3-L-serine 5'-RNA phosphodiester + RESID-alternate + + + + DiffAvg + 78.97 + + + + DiffFormula + C 0 H 0 N 0 O 3 P 1 + + + + DiffMono + 78.958505 + + + + Formula + C 3 H 5 N 1 O 5 P 1 + + + + MassAvg + 166.05 + + + + MassMono + 165.990534 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00751 + MOD:00916 + PSI-MOD + + + MOD:00219 + L-citrulline + + A protein modification that effectively converts an L-arginine residue to L-citrulline. + + 0 + DeltaMass + + + 2466844 + PubMed + + + AA0214 + RESID + + + 7#R + UniMod + + + This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group. + PSI-MOD-slim + + (S)-2-amino-5-(carbamoylamino)pentanoic acid + RESID-systematic + + + 2-amino-5-(aminocarbonyl)aminopentanoic acid + RESID-alternate + + + alpha-amino-delta-ureidovaleric acid + RESID-alternate + + + Cit + PSI-MOD-label + + + citrullinationr + OMSSA-label + + + Citrulline + DeltaMass-label + + + Deamidated + PSI-MS-label + + + Deamidated + UniMod-interim + + + Deamidation + UniMod-description + + + delta-ureidonorvaline + RESID-alternate + + + L-citrulline + RESID-name + + + MOD_RES Citrulline + UniProt-feature + + + N5-(aminocarbonyl)ornithine + RESID-alternate + + + N5-carbamoylornithine + RESID-alternate + + + N5-carbamylornithine + RESID-alternate + + + + DiffAvg + 0.98 + + + + DiffFormula + C 0 H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + C 6 H 11 N 3 O 2 + + + + MassAvg + 157.17 + + + + MassMono + 157.085127 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00902 + PSI-MOD + + + MOD:00220 + 4-hydroxy-L-arginine + + A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine. + + 10966817 + PubMed + + + 7650037 + PubMed + + + AA0215 + RESID + + + + (2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid + RESID-systematic + + + 2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer] + RESID-alternate + + + 2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer] + RESID-alternate + + + 2-amino-5-guanidino-4-hydroxypentanoic acid + RESID-alternate + + + 4-hydroxy-L-arginine + RESID-name + + + 4-hydroxylated L-arginine + PSI-MOD-alternate + + + 4HyArg + PSI-MOD-label + + + C(gamma)-hydroxyarginine + RESID-alternate + + + gamma-hydroxyarginine + RESID-alternate + + + MOD_RES 4-hydroxyarginine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 4 O 2 + + + + MassAvg + 172.19 + + + + MassMono + 172.096026 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00682 + PSI-MOD + + + MOD:00221 + N-(L-isoaspartyl)-L-cysteine + + A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine. + + 8286361 + PubMed + + + AA0216 + RESID + + + Cross-link 2. + + (S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid + RESID-systematic + + + 2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid + RESID-alternate + + + 2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid + RESID-alternate + + + CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn) + UniProt-feature + + + N-(L-isoaspartyl)-L-cysteine + RESID-name + + + N-beta-aspartylcysteine + RESID-alternate + + + N-isoaspartyl cysteine + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 S 0 + + + + DiffMono + -17.026549 + + + + Formula + C 7 H 9 N 2 O 3 S 1 + + + + MassAvg + 201.22 + + + + MassMono + 201.033388 + + + + Origin + C, N + + + + Source + natural + + + + TermSpec + N-term + + MOD:00903 + MOD:00905 + PSI-MOD + + + MOD:00222 + 2'-alpha-mannosyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan. + + 15279557 + PubMed + + + 7547911 + PubMed + + + 7947762 + PubMed + + + AA0217 + RESID + + + 41#W + UniMod + + + + (2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 2'-mannosyl-L-tryptophan + RESID-name + + + 2'-tryptophan C-mannoside + RESID-alternate + + + C2'ManTrp + PSI-MOD-label + + + CARBOHYD C-linked (Man) + UniProt-feature + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 17 H 20 N 2 O 6 + + + + MassAvg + 348.36 + + + + MassMono + 348.132136 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00421 + MOD:00595 + MOD:00761 + MOD:00918 + PSI-MOD + + + MOD:00223 + N6-mureinyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine. + + 4261992 + PubMed + + + AA0218 + RESID + + + + MOD_RES N6-murein peptidoglycan lysine + UniProt-feature + + + N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine + RESID-alternate + + + N6-mureinyl-L-lysine + RESID-name + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007825 + + + + Formula + C 6 H 11 N 2 O 1 + + + + MassAvg + 127.17 + + + + MassMono + 127.087138 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01159 + MOD:01875 + PSI-MOD + + + MOD:00224 + 1-chondroitin sulfate-L-aspartic acid ester + + A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester + + 1898736 + PubMed + + + AA0219 + RESID + + + + 1-aspartic acid ester with 6-chondroitin 4-sulfate + RESID-alternate + + + 1-chondroitin sulfate-L-aspartic acid ester + RESID-name + + + MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester + UniProt-feature + + + poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose) + RESID-alternate + + + protein-glycosaminoglycan-protein cross-link + RESID-alternate + + + + DiffAvg + 441.36 + + + + DiffFormula + C 14 H 19 N 1 O 13 S 1 + + + + DiffMono + 441.057711 + + + + Formula + C 18 H 25 N 2 O 17 S 1 + + + + MassAvg + 573.45 + + + + MassMono + 573.087393 + + + + Origin + D + + + + TermSpec + C-term + + MOD:00904 + PSI-MOD + + + MOD:00225 + S-(6-FMN)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine. + + 10869173 + PubMed + + + 1551870 + PubMed + + + 620783 + PubMed + + + AA0220 + RESID + + + 409#C + UniMod + + + PSI-MOD-slim + + (R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid + RESID-systematic + + + 6-[S-cysteinyl]flavin mononucleotide + RESID-alternate + + + 6-[S-cysteinyl]FMN + RESID-alternate + + + flavin mononucleotide + UniMod-description + + + FMNH + PSI-MS-label + + + MOD_RES S-6-FMN cysteine + UniProt-feature + + + S-(6-FMN)-L-cysteine + RESID-name + + + S6FMNCys + PSI-MOD-label + + + + DiffAvg + 454.33 + + + + DiffFormula + C 17 H 19 N 4 O 9 P 1 S 0 + + + + DiffMono + 454.088965 + + + + Formula + C 20 H 24 N 5 O 10 P 1 S 1 + + + + MassAvg + 557.47 + + + + MassMono + 557.098150 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00896 + MOD:00905 + PSI-MOD + + + MOD:00226 + 1'-(8alpha-FAD)-L-histidine + + A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine. + + 0 + DeltaMass + + + 10585424 + PubMed + + + 1396672 + PubMed + + + 4339951 + PubMed + + + 9261083 + PubMed + + + AA0221 + RESID + + + 50#H + UniMod + + + From DeltaMass: Average Mass: 784 + PSI-MOD-slim + + (S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid + RESID-systematic + + + 1'-(8alpha-FAD)-L-histidine + RESID-name + + + 8alpha-(N(epsilon)-histidyl)FAD + RESID-alternate + + + 8alpha-(N1'-histidyl)FAD + RESID-alternate + + + 8alpha-N3-histidyl FAD + RESID-misnomer + + + FAD + PSI-MS-label + + + Flavin adenine dinucleotide + UniMod-description + + + MOD_RES Tele-8alpha-FAD histidine + UniProt-feature + + + N theta and N pi-(8alpha-Flavin) (on Histidine) + DeltaMass-label + + + N(tau)-(8alpha-FAD)-histidine + RESID-alternate + + + Nt8aFADHis + PSI-MOD-label + + + tele-(8alpha-FAD)-histidine + RESID-alternate + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 + + + + DiffMono + 783.141485 + + + + Formula + C 33 H 38 N 12 O 16 P 2 + + + + MassAvg + 920.68 + + + + MassMono + 920.200396 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00895 + MOD:00909 + PSI-MOD + + + MOD:00227 + omega-N-phospho-L-arginine + + A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine. + + 8300603 + PubMed + + + AA0222 + RESID + + + 21#R + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid + RESID-systematic + + + (2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid + RESID-alternate + + + alpha-amino-delta-phosphonoguanidinovaleric acid + RESID-alternate + + + MOD_RES Phosphoarginine + UniProt-feature + + + N(gamma)-phosphoarginine + RESID-alternate + + + N(omega)-phosphono-L-arginine + RESID-alternate + + + N5-[imino(phosphonoamino)methyl]-L-ornithine + RESID-alternate + + + omega-N-phospho-L-arginine + RESID-name + + + PArg + PSI-MOD-label + + + Phospho + PSI-MS-label + + + phosphoarginine + RESID-alternate + + + Phosphorylation + UniMod-description + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 6 H 13 N 4 O 4 P 1 + + + + MassAvg + 236.17 + + + + MassMono + 236.067442 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00902 + MOD:01456 + PSI-MOD + + + MOD:00228 + S-diphytanylglycerol diether-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine. + + 7797461 + PubMed + + + 8195126 + PubMed + + + AA0223 + RESID + + + 410 + UniMod + + + incidental to RESID:AA0043. + PSI-MOD-slim + + (2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid + RESID-systematic + + + Archaeol + PSI-MS-label + + + LIPID S-archaeol cysteine + UniProt-feature + + + S-(diphytanylglyceryl)-L-cysteine + RESID-name + + + S-[2',3'-bis(phytanyloxy)propyl]cysteine + RESID-alternate + + + S-archaeol cysteine + RESID-alternate + + + S-diphytanylglycerol diether + UniMod-description + + + SPhyt2GlyceroCys + PSI-MOD-label + + + + DiffAvg + 635.16 + + + + DiffFormula + C 43 H 86 N 0 O 2 S 0 + + + + DiffMono + 634.662782 + + + + Formula + C 46 H 91 N 1 O 3 S 1 + + + + MassAvg + 738.30 + + + + MassMono + 737.671967 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01155 + PSI-MOD + + + MOD:00229 + alpha-1-microglobulin-Ig alpha complex chromophore + + A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore. + + 11058759 + PubMed + + + 11877257 + PubMed + + + 7506257 + PubMed + + + 7535251 + PubMed + + + AA0224 + RESID + + + Cross-link 2. + + alpha-1-microglobulin-Ig alpha complex chromophore + RESID-name + + + BINDING Multimeric 3-hydroxykynurenine chromophore (covalent) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 2 S 2 + + + + MassAvg + 204.26 + + + + MassMono + 204.002720 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00230 + bis-L-cysteinyl bis-L-histidino diiron disulfide + + A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide. + + 2765515 + PubMed + + + 9651245 + PubMed + + + AA0225 + RESID + + + Cross-link 4. + + bis-L-cysteinyl bis-L-histidino diiron disulfide + RESID-name + + + di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron) + RESID-systematic + + + METAL Iron-sulfur (2Fe-2S) + UniProt-feature + + + METAL Iron-sulfur (2Fe-2S); via pros nitrogen + UniProt-feature + + + Rieske iron-sulfur cofactor + RESID-alternate + + + + DiffAvg + 171.78 + + + + DiffFormula + C 0 Fe 2 H -4 N 0 O 0 S 2 + + + + DiffMono + 171.783814 + + + + FormalCharge + 2- + + + + Formula + C 18 Fe 2 H 20 N 8 O 4 S 4 + + + + MassAvg + 652.34 + + + + MassMono + 651.920007 + + + + Origin + C, C, H, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00231 + hexakis-L-cysteinyl hexairon hexasulfide + + A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide. + + 1311311 + PubMed + + + 1318833 + PubMed + + + AA0226 + RESID + + + Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon + RESID-systematic + + + hexa-mu3-sulfido-hexakis(S-cysteinyliron) + RESID-alternate + + + hexakis-L-cysteinyl hexairon hexasulfide + RESID-name + + + prismane iron-sulfur cofactor + RESID-alternate + + + + DiffAvg + 521.38 + + + + DiffFormula + C 0 Fe 6 H -6 N 0 O 0 S 6 + + + + DiffMono + 521.395649 + + + + FormalCharge + 1- + + + + Formula + C 18 Fe 6 H 24 N 6 O 6 S 12 + + + + MassAvg + 1140.22 + + + + MassMono + 1139.450758 + + + + Origin + C, C, C, C, C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00232 + N6-(phospho-5'-adenosine)-L-lysine + + A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine. + + 316 + DeltaMass + + + 3882425 + PubMed + + + 4944632 + PubMed + + + AA0227 + RESID + + + 405#K + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid + RESID-systematic + + + 5'-adenylic-N6-L-lysine + RESID-alternate + + + ACT_SITE N6-AMP-lysine intermediate + UniProt-feature + + + AMP binding site + UniMod-description + + + AMP Lysyl + DeltaMass-label + + + epsilon-5'-adenylic-L-lysine + RESID-alternate + + + L-lysine monoanhydride with 5'-adenylic acid + RESID-alternate + + + N(zeta)-5'-adenylic-L-lysine + RESID-alternate + + + N6-(phospho-5'-adenosine)-L-lysine + RESID-name + + + N6-L-lysine 5'-adenosine phosphoramidester + RESID-alternate + + + N6AMPLys + PSI-MOD-label + + + Phosphoadenosine + PSI-MS-label + + + + DiffAvg + 329.21 + + + + DiffFormula + C 10 H 12 N 5 O 6 P 1 + + + + DiffMono + 329.052520 + + + + Formula + C 16 H 24 N 7 O 7 P 1 + + + + MassAvg + 457.38 + + + + MassMono + 457.147483 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01165 + PSI-MOD + + + MOD:00233 + N6-(phospho-5'-guanosine)-L-lysine + + A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine. + + 304 + DeltaMass + + + 6092377 + PubMed + + + 6264433 + PubMed + + + AA0228 + RESID + + + 413#K + UniMod + + + From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex + PSI-MOD-slim + + (2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid + RESID-systematic + + + 5'-guanylic-N6-L-lysine + RESID-alternate + + + 5'phos Guanosyl + DeltaMass-label + + + ACT_SITE N6-GMP-lysine intermediate + UniProt-feature + + + epsilon-5'-guanylic-L-lysine + RESID-alternate + + + L-lysine monoanhydride with 5'-guanylic acid + RESID-alternate + + + lysine guanosine-5'-monophosphate + RESID-alternate + + + N(zeta)-5'-guanylic-lysine + RESID-alternate + + + N6-(5'-guanylyl)-lysine + RESID-alternate + + + N6-(phospho-5'-guanosine)-L-lysine + RESID-name + + + N6-L-lysine 5'-guanosine phosphoramidester + RESID-alternate + + + N6GMPLys + PSI-MOD-label + + + phospho-guanosine + UniMod-description + + + Phosphoguanosine + PSI-MS-label + + + + DiffAvg + 345.21 + + + + DiffFormula + C 10 H 12 N 5 O 7 P 1 + + + + DiffMono + 345.047434 + + + + Formula + C 16 H 24 N 7 O 8 P 1 + + + + MassAvg + 473.38 + + + + MassMono + 473.142397 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01163 + PSI-MOD + + + MOD:00234 + L-cysteine glutathione disulfide + + A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine. + + 21264 + ChEBI + + + 0 + DeltaMass + + + 3083866 + PubMed + + + 8344916 + PubMed + + + AA0229 + RESID + + + 55 + UniMod + + + From DeltaMass: Average Mass: 305 + PSI-MOD-slim + + (2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid + RESID-systematic + + + cysteinyl glutathione + RESID-alternate + + + Glutathionation + DeltaMass-label + + + Glutathione + PSI-MS-label + + + glutathione disulfide + UniMod-description + + + glutathionec + OMSSA-label + + + L-cysteine glutathione disulfide + RESID-name + + + L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine + RESID-alternate + + + MOD_RES S-glutathionyl cysteine + UniProt-feature + + + N-(N-gamma-glutamyl-cystinyl)-glycine + RESID-alternate + + + SGltCys + PSI-MOD-label + + + + DiffAvg + 305.30 + + + + DiffFormula + C 10 H 15 N 3 O 6 S 1 + + + + DiffMono + 305.068156 + + + + Formula + C 13 H 20 N 4 O 7 S 2 + + + + MassAvg + 408.44 + + + + MassMono + 408.077341 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01862 + PSI-MOD + + + MOD:00235 + S-nitrosyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine. + + 10442087 + PubMed + + + 11562475 + PubMed + + + 15688001 + PubMed + + + 8626764 + PubMed + + + 8637569 + PubMed + + + AA0230 + RESID + + + 275 + UniMod + + + PSI-MOD-slim + + (2R)-2-amino-3-nitrososulfanyl-propanoic acid + RESID-systematic + + + L-cysteine nitrite ester + RESID-alternate + + + MOD_RES S-nitrosocysteine + UniProt-feature + + + Nitrosyl + PSI-MS-label + + + S-nitrosocysteine + RESID-alternate + + + S-nitrosyl-L-cysteine + RESID-name + + + S-nitrosylation + UniMod-description + + + SNOCys + PSI-MOD-label + + + + DiffAvg + 29.00 + + + + DiffFormula + C 0 H -1 N 1 O 1 S 0 + + + + DiffMono + 28.990164 + + + + Formula + C 3 H 4 N 2 O 2 S 1 + + + + MassAvg + 132.14 + + + + MassMono + 131.999348 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00236 + N4-(ADP-ribosyl)-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine. + + 15842200 + PubMed + + + 2498316 + PubMed + + + AA0231 + RESID + + + 213#N + UniMod + + + + (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid + RESID-systematic + + + ADP Ribose addition + UniMod-description + + + ADP-Ribosyl + PSI-MS-label + + + MOD_RES ADP-ribosylasparagine + UniProt-feature + + + N4-(ADP-ribosyl)-L-asparagine + RESID-name + + + N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine + RESID-alternate + + + N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 19 H 27 N 7 O 15 P 2 + + + + MassAvg + 655.41 + + + + MassMono + 655.104036 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00903 + PSI-MOD + + + MOD:00237 + L-beta-methylthioaspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid. + + 61 + DeltaMass + + + 15473684 + PubMed + + + 8844851 + PubMed + + + AA0232 + RESID + + + 39#D + UniMod + + + PSI-MOD-slim + + (2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid + RESID-systematic + + + 3-(methylthio)-L-aspartic acid + RESID-name + + + 3-carboxy-S-methyl-cysteine + RESID-alternate + + + 3-methylthio-aspartic acid + RESID-alternate + + + 3MeSAsp + PSI-MOD-label + + + beta-Methylthio-aspartic acid + DeltaMass-label + + + beta-methylthio-aspartic acid + RESID-alternate + + + Beta-methylthiolation + UniMod-description + + + bmethylthiold + OMSSA-label + + + Methylthio + UniMod-interim + + + methythiold + OMSSA-label + + + MOD_RES 3-methylthioaspartic acid + UniProt-feature + + + + DiffAvg + 46.09 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 1 + + + + DiffMono + 45.987721 + + + + Formula + C 5 H 7 N 1 O 3 S 1 + + + + MassAvg + 161.18 + + + + MassMono + 161.014664 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01153 + PSI-MOD + + + MOD:00238 + 5'-(N6-L-lysine)-L-topaquinone + + A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone. + + 8688089 + PubMed + + + AA0233 + RESID + + + Cross-link 2; secondary to RESID:AA0147. + + 1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione + RESID-systematic + + + 2'-(L-lys-N6-yl)-L-4',5'-topaquinone + RESID-name + + + 2'-(L-lysine)-L-tyrosyl-4',5'-quinone + RESID-alternate + + + CROSSLNK Lysine tyrosylquinone (Lys-Tyr) + UniProt-feature + + + CROSSLNK Lysine tyrosylquinone (Tyr-Lys) + UniProt-feature + + + LTQ + RESID-alternate + + + lysyl oxidase cofactor + RESID-alternate + + + + DiffAvg + 11.97 + + + + DiffFormula + C 0 H -4 N 0 O 1 + + + + DiffMono + 11.963614 + + + + Formula + C 15 H 17 N 3 O 4 + + + + MassAvg + 303.32 + + + + MassMono + 303.121906 + + + + Origin + K, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00912 + MOD:00919 + PSI-MOD + + + MOD:00239 + S-methyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine. + + 10660523 + PubMed + + + 11875433 + PubMed + + + 1339288 + PubMed + + + AA0234 + RESID + + + 34#C + UniMod + + + PSI-MOD-slim + + (R)-2-amino-3-(methylsulfanyl)propanoic acid + RESID-systematic + + + ACT_SITE S-methylcysteine intermediate + UniProt-feature + + + L-3-(methylthio)alanine + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES S-methylcysteine + UniProt-feature + + + S-methyl-L-cysteine + RESID-name + + + S-methylated L-cysteine + PSI-MOD-alternate + + + SMeCys + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 0 + + + + DiffMono + 14.015650 + + + + Formula + C 4 H 7 N 1 O 1 S 1 + + + + MassAvg + 117.17 + + + + MassMono + 117.024835 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00654 + MOD:01682 + PSI-MOD + + + MOD:00240 + 4-hydroxy-L-lysine + + A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine. + + 4005040 + PubMed + + + AA0235 + RESID + + + This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2S,4R)-2,6-diamino-4-hydroxyhexanoic acid + RESID-systematic + + + 4-hydroxy-L-lysine + RESID-name + + + 4-hydroxylated L-lysine + PSI-MOD-alternate + + + 4HyLys + PSI-MOD-label + + + alpha,epsilon-diamino-gamma-hydroxycaproic acid + RESID-alternate + + + L-threo-gamma-hydroxylysine + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 2 O 2 + + + + MassAvg + 144.17 + + + + MassMono + 144.089878 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01047 + PSI-MOD + + + MOD:00241 + N4-hydroxymethyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine. + + AA0236 + RESID + + + 414 + UniMod + + + N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid + RESID-systematic + + + 2-amino-N4-hydroxymethylbutanediamic acid + RESID-alternate + + + beta-hydroxymethylasparagine + RESID-alternate + + + Hydroxymethyl + PSI-MS-label + + + hydroxymethyl + UniMod-description + + + N(gamma)-hydroxymethylasparagine + RESID-alternate + + + N4-hydroxymethyl-L-asparagine + RESID-name + + + N4-hydroxymethylasparagine + RESID-alternate + + + + DiffAvg + 30.03 + + + + DiffFormula + C 1 H 2 N 0 O 1 + + + + DiffMono + 30.010565 + + + + Formula + C 5 H 8 N 2 O 3 + + + + MassAvg + 144.13 + + + + MassMono + 144.053492 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:00903 + PSI-MOD + + + MOD:00242 + O-(ADP-ribosyl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine. + + 15842200 + PubMed + + + 3141412 + PubMed + + + AA0237 + RESID + + + 213#S + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid + RESID-systematic + + + ADP Ribose addition + UniMod-description + + + ADP-Ribosyl + PSI-MS-label + + + MOD_RES ADP-ribosylserine + UniProt-feature + + + O-(ADP-ribosyl)-L-serine + RESID-name + + + O3-(ADP-ribosyl)-L-serine + RESID-alternate + + + O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine + RESID-alternate + + + O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + OADPRibSer + PSI-MOD-label + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 18 H 26 N 6 O 15 P 2 + + + + MassAvg + 628.38 + + + + MassMono + 628.093137 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00916 + PSI-MOD + + + MOD:00243 + L-cysteine oxazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. + + 8183941 + PubMed + + + 8895467 + PubMed + + + AA0238 + RESID + + + Cross-link 2. + + 2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid + RESID-alternate + + + 2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser) + UniProt-feature + + + L-cysteine oxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 6 H 6 N 2 O 2 S 1 + + + + MassAvg + 170.19 + + + + MassMono + 170.014998 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01421 + MOD:01888 + PSI-MOD + + + MOD:00244 + L-cysteine oxazoline-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid. + + 1880060 + PubMed + + + AA0239 + RESID + + + Cross-link 2. + + (4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser) + UniProt-feature + + + L-cysteine oxazoline-4-carboxylic acid + RESID-name + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01421 + PSI-MOD + + + MOD:00245 + glycine oxazole-4-carboxylic acid + + A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid. + + 8183941 + PubMed + + + 8895467 + PubMed + + + AA0240 + RESID + + + Cross-link 2. + + 2-aminomethyl-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-azanylmethyl-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser) + UniProt-feature + + + glycine oxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 5 H 4 N 2 O 2 + + + + MassAvg + 124.10 + + + + MassMono + 124.027277 + + + + Origin + G, S + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:01421 + MOD:01888 + PSI-MOD + + + MOD:00246 + glycine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid. + + 21276 + ChEBI + + + 8183941 + PubMed + + + 8895467 + PubMed + + + AA0241 + RESID + + + Cross-link 2. + + 2-(aminomethyl)-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys) + UniProt-feature + + + glycine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 5 H 4 N 2 O 1 S 1 + + + + MassAvg + 140.16 + + + + MassMono + 140.004434 + + + + Origin + C, G + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:00247 + L-serine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid. + + 8183941 + PubMed + + + 8895467 + PubMed + + + AA0242 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys) + UniProt-feature + + + L-serine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 6 H 6 N 2 O 2 S 1 + + + + MassAvg + 170.19 + + + + MassMono + 170.014998 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:00248 + L-phenylalanine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid. + + 1880060 + PubMed + + + AA0243 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys) + UniProt-feature + + + L-phenylalanine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 12 H 10 N 2 O 1 S 1 + + + + MassAvg + 230.29 + + + + MassMono + 230.051384 + + + + Origin + C, F + + + + Source + natural + + + + TermSpec + none + + MOD:00914 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:00249 + L-cysteine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid. + + 1880060 + PubMed + + + AA0244 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys) + UniProt-feature + + + L-cysteine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 6 H 6 N 2 O 1 S 2 + + + + MassAvg + 186.25 + + + + MassMono + 185.992155 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:00250 + L-lysine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid. + + 1880060 + PubMed + + + AA0245 + RESID + + + Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + 2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + L-lysine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 9 H 13 N 3 O 1 S 1 + + + + MassAvg + 211.28 + + + + MassMono + 211.077933 + + + + Origin + C, K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00912 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:00251 + O-(phospho-5'-DNA)-L-serine + + A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine. + + 7142163 + PubMed + + + 7265205 + PubMed + + + AA0246 + RESID + + + + (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid + RESID-systematic + + + ACT_SITE O-(5'-phospho-DNA)-serine intermediate + UniProt-feature + + + MOD_RES O-(5'-phospho-DNA)-serine + UniProt-feature + + + O-(phospho-5'-DNA)-L-serine + RESID-name + + + O3-(phospho-5'-DNA)-L-serine + RESID-alternate + + + O3-L-serine 5'-DNA phosphodiester + RESID-alternate + + + + DiffAvg + 78.97 + + + + DiffFormula + C 0 H 0 N 0 O 3 P 1 + + + + DiffMono + 78.958505 + + + + Formula + C 3 H 5 N 1 O 5 P 1 + + + + MassAvg + 166.05 + + + + MassMono + 165.990534 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00750 + MOD:00916 + PSI-MOD + + + MOD:00252 + keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine + + A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. + + 1417734 + PubMed + + + 3472204 + PubMed + + + AA0247 + RESID + + + + keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine + RESID-name + + + keratosulfate + RESID-alternate + + + poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine + RESID-systematic + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007825 + + + + Formula + C 4 H 6 N 1 O 2 + + + + MassAvg + 100.10 + + + + MassMono + 100.039853 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00005 + PSI-MOD + + + MOD:00253 + L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec) + + A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). + + 14235557 + PubMed + + + 2211698 + PubMed + + + 8052647 + PubMed + + + 9036855 + PubMed + + + AA0248#SEC + RESID + + + 415 + UniMod + + + + + DiffAvg + 1572.02 + + + + DiffFormula + C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0 + + + + DiffMono + 1572.985775 + + + + Formula + C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1 + + + + MassAvg + 1722.07 + + + + MassMono + 1723.939410 + + + + Origin + U + + + + Source + natural + + + + TermSpec + none + + MOD:00744 + MOD:01158 + PSI-MOD + + + MOD:00254 + O4'-(phospho-5'-RNA)-L-tyrosine + + A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine. + + 1702164 + PubMed + + + 209034 + PubMed + + + 217003 + PubMed + + + 6264310 + PubMed + + + AA0249 + RESID + + + + (S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid + RESID-systematic + + + MOD_RES O-(5'-phospho-RNA)-tyrosine + UniProt-feature + + + O4'-(phospho-5'-RNA)-L-tyrosine + RESID-name + + + O4'-L-tyrosine 5'-RNA phosphodiester + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 9 H 10 N 1 O 5 P 1 + + + + MassAvg + 243.15 + + + + MassMono + 243.029659 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00751 + MOD:00919 + PSI-MOD + + + MOD:00255 + 3-(3'-L-histidyl)-L-tyrosine + + A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine. + + 9144772 + PubMed + + + AA0250 + RESID + + + Cross-link 2. + + (2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid + RESID-systematic + + + 3-(3'-L-histidyl)-L-tyrosine + RESID-name + + + 3-(N3'-histidyl)tyrosine + RESID-alternate + + + 3-(pi-histidyl)tyrosine + RESID-alternate + + + 3-(pros-histidyl)tyrosine + RESID-alternate + + + beta-(N(delta)-histidyl)tyrosine + RESID-alternate + + + beta-(N3'-histidyl)tyrosine + RESID-alternate + + + CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 15 H 14 N 4 O 3 + + + + MassAvg + 298.30 + + + + MassMono + 298.106590 + + + + Origin + H, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00909 + MOD:00919 + PSI-MOD + + + MOD:00256 + L-methionine sulfone + + A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone. + + 205 + DeltaMass + + + 12686488 + PubMed + + + 7786407 + PubMed + + + 7791219 + PubMed + + + 9252331 + PubMed + + + AA0251 + RESID + + + 425#M + UniMod + + + DeltaMass gives the formula C 5 H 9 N 3 O 1 S 1 with mass 163 + PSI-MOD-slim + + (2S)-2-amino-4-(methylsulfonyl)butanoic acid + RESID-systematic + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + L-methionine S,S-dioxide + RESID-alternate + + + L-methionine sulfone + RESID-name + + + MethionylSulphone + DeltaMass-label + + + MetO2 + PSI-MOD-label + + + MOD_RES Methionine sulfone + UniProt-feature + + + Oxidation of Methionine (to Sulphone) + DeltaMass-label + + + S,S-dioxymethionine + RESID-alternate + + + suphonem + OMSSA-label + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 S 0 + + + + DiffMono + 31.989829 + + + + Formula + C 5 H 9 N 1 O 3 S 1 + + + + MassAvg + 163.19 + + + + MassMono + 163.030314 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:00709 + MOD:01855 + PSI-MOD + + + MOD:00257 + dipyrrolylmethanemethyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine. + + 3042456 + PubMed + + + 3196304 + PubMed + + + 3421931 + PubMed + + + 8727319 + PubMed + + + AA0252 + RESID + + + 416 + UniMod + + + + (2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid + RESID-systematic + + + 3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid + RESID-alternate + + + dipyrrole cofactor + RESID-alternate + + + Dipyrrolylmethanemethyl + PSI-MS-label + + + dipyrrolylmethanemethyl + UniMod-description + + + dipyrrolylmethanemethyl-L-cysteine + RESID-name + + + dipyrrolylmethyl-L-cysteine + RESID-alternate + + + dipyrromethane cofactor + RESID-alternate + + + MOD_RES S-(dipyrrolylmethanemethyl)cysteine + UniProt-feature + + + pyrromethane cofactor + RESID-alternate + + + + DiffAvg + 418.40 + + + + DiffFormula + C 20 H 22 N 2 O 8 S 0 + + + + DiffMono + 418.137616 + + + + Formula + C 23 H 27 N 3 O 9 S 1 + + + + MassAvg + 521.54 + + + + MassMono + 521.146800 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00258 + S-(2-aminovinyl)-3-methyl-D-cysteine + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine. + + 9119018 + PubMed + + + AA0253 + RESID + + + Cross-link 2. + + (2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid + RESID-systematic + + + 2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid + RESID-alternate + + + CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys) + UniProt-feature + + + decarboxylated methyllanthionine + RESID-alternate + + + S-(2-aminovinyl)-3-methyl-D-cysteine + RESID-name + + + + DiffAvg + -64.04 + + + + DiffFormula + C -1 H -4 N 0 O -3 S 0 + + + + DiffMono + -64.016044 + + + + Formula + C 6 H 9 N 2 O 1 S 1 + + + + MassAvg + 157.21 + + + + MassMono + 157.043559 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00687 + MOD:00917 + PSI-MOD + + + MOD:00259 + O4'-(phospho-5'-DNA)-L-tyrosine + + A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine. + + 1861973 + PubMed + + + 2940511 + PubMed + + + 3684578 + PubMed + + + AA0254 + RESID + + + + (S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid + RESID-systematic + + + ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate + UniProt-feature + + + MOD_RES O-(5'-phospho-DNA)-tyrosine + UniProt-feature + + + O4'-(phospho-5'-DNA)-L-tyrosine + RESID-name + + + O4'-L-tyrosine 5'-DNA phosphodiester + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 9 H 10 N 1 O 5 P 1 + + + + MassAvg + 243.15 + + + + MassMono + 243.029659 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00750 + MOD:00919 + PSI-MOD + + + MOD:00260 + O-(phospho-5'-DNA)-L-threonine + + A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine. + + 3081736 + PubMed + + + AA0255 + RESID + + + + (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid + RESID-systematic + + + O-(phospho-5'-DNA)-L-threonine + RESID-name + + + O3-(phospho-5'-DNA)-L-threonine + RESID-alternate + + + O3-L-threonine 5'-DNA phosphodiester + RESID-alternate + + + + DiffAvg + 78.97 + + + + DiffFormula + C 0 H 0 N 0 O 3 P 1 + + + + DiffMono + 78.958505 + + + + Formula + C 4 H 7 N 1 O 5 P 1 + + + + MassAvg + 180.08 + + + + MassMono + 180.006184 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00750 + MOD:00917 + PSI-MOD + + + MOD:00261 + O4'-(phospho-5'-uridine)-L-tyrosine + + A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine. + + 0 + DeltaMass + + + 11467524 + PubMed + + + 2885322 + PubMed + + + AA0256 + RESID + + + 417#Y + UniMod + + + From DeltaMass: Average Mass: 306. + PSI-MOD-slim + + (S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid + RESID-systematic + + + 5'-uridylic-O-tyrosine + RESID-alternate + + + hydrogen 5'-uridylate tyrosine ester + RESID-alternate + + + MOD_RES O-UMP-tyrosine + UniProt-feature + + + O-Uridinylylation (of Tyrosine) + DeltaMass-label + + + O4'-(phospho-5'-uridine)-L-tyrosine + RESID-name + + + O4'-L-tyrosine 5'-uridine phosphodiester + RESID-alternate + + + OUMPTyr + PSI-MOD-label + + + PhosphoUridine + PSI-MS-label + + + uridine phosphodiester + UniMod-description + + + + DiffAvg + 306.17 + + + + DiffFormula + C 9 H 11 N 2 O 8 P 1 + + + + DiffMono + 306.025302 + + + + Formula + C 18 H 20 N 3 O 10 P 1 + + + + MassAvg + 469.34 + + + + MassMono + 469.088630 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00919 + MOD:01166 + PSI-MOD + + + MOD:00262 + N-(L-glutamyl)-L-tyrosine + + A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine. + + 21477 + ChEBI + + + 6387372 + PubMed + + + 8093886 + PubMed + + + AA0257 + RESID + + + Cross-link 2. + + (S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid + RESID-systematic + + + L-glutamyl L-tyrosine + RESID-name + + + N-(L-glutamyl)-L-tyrosine + RESID-alternate + + + SITE Involved in polymerization + UniProt-feature + + + + DiffAvg + -17.01 + + + + DiffFormula + C 0 H -1 N 0 O -1 + + + + DiffMono + -17.002740 + + + + Formula + C 14 H 16 N 2 O 5 + + + + MassAvg + 292.29 + + + + MassMono + 292.105922 + + + + Origin + E, Y + + + + Source + natural + + + + TermSpec + C-term + + MOD:00906 + MOD:00919 + PSI-MOD + + + MOD:00263 + S-phycoviolobilin-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin. + + 2106585 + PubMed + + + 3208761 + PubMed + + + AA0258 + RESID + + + 387 + UniMod + + + + (4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione + RESID-systematic + + + BINDING Phycoviolobilin chromophore (covalent; via 1 link) + UniProt-feature + + + cryptobiliviolin + RESID-alternate + + + cryptoviolin + RESID-alternate + + + cryptoviolobilin + RESID-alternate + + + PBV + RESID-alternate + + + Phycocyanobilin + PSI-MS-label + + + phycocyanobilin + UniMod-description + + + PVB + RESID-alternate + + + PXB + RESID-alternate + + + S-phycobiliviolin-L-cysteine + RESID-alternate + + + S-phycoviolobilin-L-cysteine + RESID-name + + + + DiffAvg + 586.69 + + + + DiffFormula + C 33 H 38 N 4 O 6 S 0 + + + + DiffMono + 586.279135 + + + + Formula + C 36 H 43 N 5 O 7 S 1 + + + + MassAvg + 689.83 + + + + MassMono + 689.288320 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:00264 + phycoerythrobilin-bis-L-cysteine + + A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin. + + 3208761 + PubMed + + + 3838747 + PubMed + + + AA0259 + RESID + + + Cross-link 2. + + (2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione + RESID-systematic + + + 3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid + RESID-alternate + + + BINDING Phycoerythrobilin chromophore (covalent; via 2 links) + UniProt-feature + + + PEB + RESID-alternate + + + phycoerythrobilin biscysteine adduct + RESID-alternate + + + phycoerythrobilin-bis-L-cysteine + RESID-name + + + + DiffAvg + 586.69 + + + + DiffFormula + C 33 H 38 N 4 O 6 S 0 + + + + DiffMono + 586.279135 + + + + Formula + C 39 H 48 N 6 O 8 S 2 + + + + MassAvg + 792.97 + + + + MassMono + 792.297505 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:00265 + phycourobilin-bis-L-cysteine + + A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin. + + 3208761 + PubMed + + + 3838665 + PubMed + + + 3838747 + PubMed + + + 8876649 + PubMed + + + AA0260 + RESID + + + Cross-link 2. + + 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid + RESID-alternate + + + 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione + RESID-systematic + + + BINDING Phycourobilin chromophore (covalent; via 2 links) + UniProt-feature + + + phycourobilin biscysteine adduct + RESID-alternate + + + phycourobilin-bis-L-cysteine + RESID-name + + + PUB + RESID-alternate + + + + DiffAvg + 586.69 + + + + DiffFormula + C 33 H 38 N 4 O 6 S 0 + + + + DiffMono + 586.279135 + + + + Formula + C 39 H 48 N 6 O 8 S 2 + + + + MassAvg + 792.97 + + + + MassMono + 792.297505 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:00266 + N-L-glutamyl-poly-L-glutamic acid + + A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid. + + 2570347 + PubMed + + + 328274 + PubMed + + + AA0261 + RESID + + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 10 H 15 N 2 O 7 + + + + MassAvg + 275.24 + + + + MassMono + 275.087926 + + + + Origin + E + + + + Source + natural + + + + TermSpec + C-term + + MOD:00906 + PSI-MOD + + + MOD:00267 + L-cysteine sulfinic acid + + A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid. + + 16345 + ChEBI + + + 12686488 + PubMed + + + 9252331 + PubMed + + + 9586994 + PubMed + + + AA0262 + RESID + + + 425#C + UniMod + + + "Hyun Ae Woo, et. al., Science 300 (5619), 653-656" + PSI-MOD-slim + + (2R)-2-amino-3-sulfinopropanoic acid + RESID-systematic + + + 2-amino-2-carboxyethanesulfinic acid + RESID-alternate + + + 2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer] + RESID-alternate + + + 2-amino-3-sulfonylpropanoic acid [tautomer] + RESID-alternate + + + 3-sulfinoalanine + RESID-alternate + + + 3-sulphinoalanine + RESID-alternate + + + CysO2H + PSI-MOD-label + + + cysteine sulphinic acid + RESID-alternate + + + cysteine-S,S-dioxide [tautomer] + RESID-alternate + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + L-cysteine sulfinic acid + RESID-name + + + MOD_RES Cysteine sulfinic acid (-SO2H) + UniProt-feature + + + S-cysteinesulfinic acid + RESID-alternate + + + S-sulfinocysteine + RESID-alternate + + + sulfinicacid + OMSSA-label + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 S 0 + + + + DiffMono + 31.989829 + + + + Formula + C 3 H 5 N 1 O 3 S 1 + + + + MassAvg + 135.14 + + + + MassMono + 134.999014 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00708 + MOD:01855 + PSI-MOD + + + MOD:00268 + L-3',4',5'-trihydroxyphenylalanine + + A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine. + + 0 + DeltaMass + + + 12686488 + PubMed + + + 12771378 + PubMed + + + 8554314 + PubMed + + + 9252331 + PubMed + + + 9434739 + PubMed + + + AA0263 + RESID + + + 425#Y + UniMod + + + From DeltaMass: Average Mass: 32 + + (S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid + RESID-systematic + + + 3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA) + DeltaMass-label + + + 35Hy2Tyr + PSI-MOD-label + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + L-3',4',5'-trihydroxyphenylalanine + RESID-name + + + L-3,4,5-TOPA + RESID-alternate + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 9 H 9 N 1 O 4 + + + + MassAvg + 195.17 + + + + MassMono + 195.053158 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00428 + MOD:00707 + PSI-MOD + + + MOD:00269 + O-(sn-1-glycerophosphoryl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine. + + 8645220 + PubMed + + + AA0264 + RESID + + + 419#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid + RESID-systematic + + + alpha-glycerophosphoryl serine + RESID-alternate + + + Glycerophospho + PSI-MS-label + + + glycerophospho + UniMod-description + + + glycerophosphoserine + RESID-alternate + + + MOD_RES O-(sn-1-glycerophosphoryl)serine + UniProt-feature + + + O-(sn-1-glycerophosphoryl)-L-serine + RESID-name + + + O3-(sn-1-glycerophosphoryl)-L-serine + RESID-alternate + + + O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester + RESID-alternate + + + O3-L-serine glyceryl-1-phosphodiester + RESID-alternate + + + + DiffAvg + 154.06 + + + + DiffFormula + C 3 H 7 N 0 O 5 P 1 + + + + DiffMono + 154.003110 + + + + Formula + C 6 H 12 N 1 O 7 P 1 + + + + MassAvg + 241.14 + + + + MassMono + 241.035138 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + PSI-MOD + + + MOD:00270 + 1-thioglycine (internal) + + A protein modification that effectively converts a glycine residue to an internal 1-thioglycine. + + 11463785 + PubMed + + + 9367957 + PubMed + + + AA0265#INT + RESID + + + This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid). + PSI-MOD-slim + + 1-thioglycine + RESID-name + + + 2-amino-1-sulfanylethanone + RESID-alternate + + + aminoethanethioic acid + RESID-systematic + + + aminoethanethioic O-acid + RESID-alternate + + + aminoethanethionic acid + RESID-alternate + + + aminothioacetic acid + RESID-alternate + + + Carboxy->Thiocarboxy + PSI-MS-label + + + MOD_RES 1-thioglycine + UniProt-feature + + + S(O)Gly + PSI-MOD-label + + + thiocarboxylic acid + UniMod-description + + + + DiffAvg + 16.06 + + + + DiffFormula + C 0 H 0 N 0 O -1 S 1 + + + + DiffMono + 15.977156 + + + + Formula + C 2 H 3 N 1 S 1 + + + + MassAvg + 73.11 + + + + MassMono + 72.998620 + + + + Origin + G + + + + Source + natural + + + + TermSpec + none + + MOD:01625 + PSI-MOD + + + MOD:00271 + heme P460-bis-L-cysteine-L-tyrosine + + A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 8325841 + PubMed + + + 9095195 + PubMed + + + AA0266 + RESID + + + Cross-link 3. + + (10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + BINDING Heme (covalent; via 3 links) + UniProt-feature + + + bis(S-cysteinyl)-(tyros-3'-yl)-heme + RESID-alternate + + + heme P460-bis-L-cysteine-L-tyrosine + RESID-name + + + + DiffAvg + 614.48 + + + + DiffFormula + C 34 Fe 1 H 30 N 4 O 4 S 0 + + + + DiffMono + 614.161643 + + + + Formula + C 49 Fe 1 H 49 N 7 O 8 S 2 + + + + MassAvg + 983.94 + + + + MassMono + 983.243341 + + + + Origin + C, C, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00905 + MOD:00919 + PSI-MOD + + + MOD:00272 + O-(phospho-5'-adenosine)-L-threonine + + A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine. + + 2989287 + PubMed + + + 8917428 + PubMed + + + AA0267 + RESID + + + 405#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid + RESID-systematic + + + 5'-adenylic-O3-L-threonine + RESID-alternate + + + ACT_SITE O-AMP-threonine intermediate + UniProt-feature + + + AMP binding site + UniMod-description + + + beta-5'-adenylic-L-threonine + RESID-alternate + + + L-threonine monoanhydride with 5'-adenylic acid + RESID-alternate + + + MOD_RES O-AMP-threonine + UniProt-feature + + + O(gamma)-5'-adenylic-L-threonine + RESID-alternate + + + O-(phospho-5'-adenosine)-L-threonine + RESID-name + + + O3-(phospho-5'-adenosine)-L-threonine + RESID-alternate + + + O3-L-threonine 5'-adenosine phosphodiester + RESID-alternate + + + Phosphoadenosine + PSI-MS-label + + + + DiffAvg + 329.21 + + + + DiffFormula + C 10 H 12 N 5 O 6 P 1 + + + + DiffMono + 329.052520 + + + + Formula + C 14 H 19 N 6 O 8 P 1 + + + + MassAvg + 430.31 + + + + MassMono + 430.100198 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01165 + PSI-MOD + + + MOD:00273 + tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide + + A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide. + + 12764602 + PubMed + + + AA0268 + RESID + + + Cross-link 7; secondary to RESID:AA0269. + + 4Fe-2S-3O cluster + RESID-alternate + + + hybrid four iron cluster 2 + RESID-alternate + + + METAL Iron-oxo-sulfur (4Fe-2O-2S) + UniProt-feature + + + METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group + UniProt-feature + + + METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen + UniProt-feature + + + mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron) + RESID-systematic + + + prismane iron-sulfur cofactor + RESID-misnomer + + + tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide + RESID-name + + + + DiffAvg + 360.50 + + + + DiffFormula + C 0 Fe 4 H -7 N 0 O 3 S 3 + + + + DiffMono + 360.585932 + + + + Formula + C 28 Fe 4 H 34 N 9 O 14 S 7 + + + + MassAvg + 1168.43 + + + + MassMono + 1167.766769 + + + + Origin + C, C, C, C, E, E, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00906 + MOD:00909 + PSI-MOD + + + MOD:00274 + L-cysteine persulfide + + A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide. + + 28839 + ChEBI + + + 15096637 + PubMed + + + 4276457 + PubMed + + + 8161529 + PubMed + + + AA0269 + RESID + + + 421 + UniMod + + + PSI-MOD-slim + + (R)-2-amino-3-disulfanylpropanoic acid + RESID-systematic + + + 2-amino-3-disulfanylpropanoic acid + RESID-alternate + + + 2-amino-3-hydrodisulfidopropanoic acid + RESID-alternate + + + 2-amino-3-hydropersulfidopropanoic acid + RESID-alternate + + + 2-amino-3-persulfhydrylpropanoic acid + RESID-alternate + + + 3-(thiosulfeno)-alanine + RESID-alternate + + + 3-disulfanylalanine + RESID-alternate + + + ACT_SITE Cysteine persulfide intermediate + UniProt-feature + + + L-cysteine persulfide + RESID-name + + + MOD_RES Cysteine persulfide + UniProt-feature + + + persulfide + UniMod-description + + + S-mercaptocysteine + RESID-alternate + + + S-sulfanylcysteine + RESID-alternate + + + Sulfide + PSI-MS-label + + + thiocysteine + RESID-alternate + + + + DiffAvg + 32.06 + + + + DiffFormula + C 0 H 0 N 0 O 0 S 1 + + + + DiffMono + 31.972071 + + + + Formula + C 3 H 5 N 1 O 1 S 2 + + + + MassAvg + 135.20 + + + + MassMono + 134.981256 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01886 + PSI-MOD + + + MOD:00275 + 3'-(1'-L-histidyl)-L-tyrosine + + A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine. + + 19837 + ChEBI + + + 10338009 + PubMed + + + AA0270 + RESID + + + Cross-link 2. + PSI-MOD-slim + + (2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid + RESID-systematic + + + 3'-(1'-L-histidyl)-L-tyrosine + RESID-name + + + 3'-(N(epsilon)-histidyl)tyrosine + RESID-alternate + + + 3'-(N1'-histidyl)tyrosine + RESID-alternate + + + 3'-(tau-histidyl)tyrosine + RESID-alternate + + + 3'-(tele-histidyl)tyrosine + RESID-alternate + + + CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 15 H 14 N 4 O 3 + + + + MassAvg + 298.30 + + + + MassMono + 298.106590 + + + + Origin + H, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00909 + MOD:00919 + PSI-MOD + + + MOD:00276 + heme P460-bis-L-cysteine-L-lysine + + A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 12709052 + PubMed + + + 9237682 + PubMed + + + AA0271 + RESID + + + Cross-link 3. + + (19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + BINDING Heme (covalent; via 3 links) + UniProt-feature + + + bis(S-cysteinyl)-N6-lysino-heme + RESID-alternate + + + heme P460-bis-L-cysteine-L-lysine + RESID-name + + + + DiffAvg + 614.48 + + + + DiffFormula + C 34 Fe 1 H 30 N 4 O 4 S 0 + + + + DiffMono + 614.161643 + + + + Formula + C 46 Fe 1 H 52 N 8 O 7 S 2 + + + + MassAvg + 948.94 + + + + MassMono + 948.274976 + + + + Origin + C, C, K + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00905 + MOD:00912 + PSI-MOD + + + MOD:00277 + 5-methyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine. + + 10660523 + PubMed + + + 11875433 + PubMed + + + 9367957 + PubMed + + + AA0272 + RESID + + + + (2S,5S)-2-amino-5-carbamimidamidohexanoic acid + RESID-systematic + + + 2-amino-5-guanidinohexanoic acid + RESID-alternate + + + 4-methylarginine + RESID-misnomer + + + 5-methyl-L-arginine + RESID-name + + + 5-methylated L-arginine + PSI-MOD-alternate + + + C5Me1Arg + PSI-MOD-label + + + delta-methylarginine + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES 5-methylarginine + UniProt-feature + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 14 N 4 O 1 + + + + MassAvg + 170.22 + + + + MassMono + 170.116761 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00414 + MOD:00656 + PSI-MOD + + + MOD:00278 + 2-methyl-L-glutamine + + A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine. + + 10660523 + PubMed + + + 11875433 + PubMed + + + 9367957 + PubMed + + + AA0273 + RESID + + + + (S)-2-amino-2-methylpentanediamic acid + RESID-systematic + + + 2-methyl-L-glutamine + RESID-name + + + 2-methylated L-glutamine + PSI-MOD-alternate + + + 2-methylglutamine + RESID-alternate + + + alpha-methylglutamine + RESID-alternate + + + C2MeGln + PSI-MOD-label + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES 2-methylglutamine + UniProt-feature + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 10 N 2 O 2 + + + + MassAvg + 142.16 + + + + MassMono + 142.074228 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00656 + MOD:00722 + PSI-MOD + + + MOD:00279 + N-pyruvic acid 2-iminyl-L-cysteine + + A protein modification that effectively converts an Lcysteline residue to N-pyruvic acid 2-iminyl-L-cysteine. + + 1388164 + PubMed + + + AA0274 + RESID + + + 422#C + UniMod + + + PSI-MOD-slim + + (R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid + RESID-systematic + + + MOD_RES N-pyruvate 2-iminyl-cysteine + UniProt-feature + + + N-pyruvic acid 2-iminyl + UniMod-description + + + N-pyruvic acid 2-iminyl-L-cysteine + RESID-name + + + PyruvicAcidIminyl + PSI-MS-label + + + + DiffAvg + 70.05 + + + + DiffFormula + C 3 H 2 N 0 O 2 S 0 + + + + DiffMono + 70.005479 + + + + Formula + C 6 H 8 N 1 O 3 S 1 + + + + MassAvg + 174.19 + + + + MassMono + 174.022489 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + MOD:01170 + PSI-MOD + + + MOD:00280 + N-pyruvic acid 2-iminyl-L-valine + + A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine. + + 2071591 + PubMed + + + AA0275 + RESID + + + 422#V + UniMod + + + PSI-MOD-slim + + (S)-2-(1-carboxy-2-methylpropanimino)propanoic acid + RESID-systematic + + + MOD_RES N-pyruvate 2-iminyl-valine + UniProt-feature + + + N-pyruvic acid 2-iminyl + UniMod-description + + + N-pyruvic acid 2-iminyl-L-valine + RESID-name + + + PyruvicAcidIminyl + PSI-MS-label + + + + DiffAvg + 70.05 + + + + DiffFormula + C 3 H 2 N 0 O 2 + + + + DiffMono + 70.005479 + + + + Formula + C 8 H 12 N 1 O 3 + + + + MassAvg + 170.19 + + + + MassMono + 170.081718 + + + + Origin + V + + + + Source + natural + + + + TermSpec + N-term + + MOD:00920 + MOD:01170 + PSI-MOD + + + MOD:00281 + 3'-heme-L-histidine + + A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 12119398 + PubMed + + + 12429096 + PubMed + + + 12486054 + PubMed + + + 9712585 + PubMed + + + AA0276 + RESID + + + + 2-[1-(N3'-histidyl)ethyl]protoporphyrin IX + RESID-alternate + + + 3'-heme-L-histidine + RESID-name + + + [7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + BINDING Heme (covalent; via pros nitrogen) + UniProt-feature + + + N(delta)-histidyl heme + RESID-alternate + + + N(pi)-histidyl heme + RESID-alternate + + + N3'-histidyl heme + RESID-alternate + + + pros-histidyl heme + RESID-alternate + + + + DiffAvg + 616.50 + + + + DiffFormula + C 34 Fe 1 H 32 N 4 O 4 + + + + DiffMono + 616.177293 + + + + Formula + C 40 Fe 1 H 39 N 7 O 5 + + + + MassAvg + 753.64 + + + + MassMono + 753.236205 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00909 + PSI-MOD + + + MOD:00282 + S-selenyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine. + + 10430865 + PubMed + + + 10966817 + PubMed + + + 11827487 + PubMed + + + 12716131 + PubMed + + + 14594807 + PubMed + + + AA0277 + RESID + + + 423#C + UniMod + + + + (R)-2-amino-3-(selanylsulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-hydroselenosulfidopropanoic acid + RESID-alternate + + + 2-amino-3-hydroselenylsulfidopropanoic acid + RESID-alternate + + + 2-amino-3-hydroselenylthiopropanoic acid + RESID-alternate + + + ACT_SITE S-selanylcysteine intermediate + UniProt-feature + + + cysteine perselenide + RESID-misnomer + + + Delta:Se(1) + PSI-MS-label + + + MOD_RES S-selanylcysteine + UniProt-feature + + + S-selanyl-L-cysteine + RESID-name + + + S-selanylcysteine + RESID-alternate + + + S-selenylcysteine + RESID-alternate + + + selenyl + UniMod-description + + + + DiffAvg + 78.97 + + + + DiffFormula + C 0 H 0 N 0 O 0 S 0 Se 1 + + + + DiffMono + 79.916521 + + + + Formula + C 3 H 5 N 1 O 1 S 1 Se 1 + + + + MassAvg + 182.11 + + + + MassMono + 182.925706 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00745 + MOD:00778 + MOD:00905 + PSI-MOD + + + MOD:00283 + N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine + + A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine. + + 10550045 + PubMed + + + 11349130 + PubMed + + + AA0278 + RESID + + + + (alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)] + RESID-systematic + + + lysine derivative Lys(x) + RESID-alternate + + + MOD_RES N6-poly(methylaminopropyl)lysine + UniProt-feature + + + N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine + RESID-alternate + + + N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine + RESID-name + + + silaffin polycationic lysine derivative + RESID-alternate + + + + DiffAvg + 426.74 + + + + DiffFormula + C 24 H 54 N 6 O 0 + + + + DiffMono + 426.440996 + + + + Formula + C 30 H 66 N 8 O 1 + + + + MassAvg + 554.91 + + + + MassMono + 554.535959 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00284 + dihydroxyheme-L-aspartate ester-L-glutamate ester + + A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 10447690 + PubMed + + + AA0279 + RESID + + + Cross-link 2. + + 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester + RESID-alternate + + + [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + BINDING Heme (covalent; via 2 links) + UniProt-feature + + + dihydroxyheme-L-aspartate ester-L-glutamate ester + RESID-name + + + peroxidase heme cofactor + RESID-alternate + + + + DiffAvg + 612.47 + + + + DiffFormula + C 34 Fe 1 H 28 N 4 O 4 + + + + DiffMono + 612.145993 + + + + Formula + C 43 Fe 1 H 40 N 6 O 10 + + + + MassAvg + 856.67 + + + + MassMono + 856.215529 + + + + Origin + D, E + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00699 + MOD:00904 + MOD:00906 + PSI-MOD + + + MOD:00285 + dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium + + A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 10447690 + PubMed + + + 10480885 + PubMed + + + 1320128 + PubMed + + + 7840679 + PubMed + + + AA0280 + RESID + + + Cross-link 3. + + 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium + RESID-alternate + + + [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + BINDING Heme (covalent; via 3 links) + UniProt-feature + + + dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium + RESID-name + + + myeloperoxidase heme cofactor + RESID-alternate + + + + DiffAvg + 613.47 + + + + DiffFormula + C 34 Fe 1 H 29 N 4 O 4 S 0 + + + + DiffMono + 613.153269 + + + + FormalCharge + 1+ + + + + Formula + C 48 Fe 1 H 50 N 7 O 11 S 1 + + + + MassAvg + 988.87 + + + + MassMono + 988.263290 + + + + Origin + D, E, M + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00904 + MOD:00906 + MOD:00913 + PSI-MOD + + + MOD:00286 + L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) + + A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide). + + AA0281 + RESID + + + 424#C + UniMod + + + + 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide + RESID-alternate + + + bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum + RESID-systematic + + + L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) + RESID-name + + + molybdenum bis(molybdopterin guanine dinucleotide) + UniMod-description + + + MolybdopterinGD + PSI-MS-label + + + + DiffAvg + 1572.02 + + + + DiffFormula + C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 + + + + DiffMono + 1572.985775 + + + + Formula + C 43 H 52 Mo 1 N 21 O 27 P 4 S 5 + + + + MassAvg + 1675.15 + + + + MassMono + 1675.994960 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00905 + MOD:01167 + PSI-MOD + + + MOD:00287 + (2S,3R,4S)-3,4-dihydroxyproline + + A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline. + + 0 + DeltaMass + + + 12686488 + PubMed + + + AA0282 + RESID + + + 425#P + UniMod + + + From DeltaMass: Average Mass: 32. + + (2S,3R,4S)-3,4-dihydroxyproline + RESID-name + + + (2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid + RESID-systematic + + + 2,3-trans-3,4-cis-3,4-dihydroxy-L-proline + RESID-alternate + + + 2-alpha-3-beta-4-beta-3,4-dihydroxyproline + RESID-alternate + + + 3,4-dihydroxylated L-proline + PSI-MOD-alternate + + + 3,4-Dihydroxylation (of Proline) + DeltaMass-label + + + 34Hy2Pro + PSI-MOD-label + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + MOD_RES (3R,4S)-3,4-dihydroxyproline + UniProt-feature + + + trans-2,3-cis-3,4-dihydroxy-L-proline + RESID-alternate + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00866 + PSI-MOD + + + MOD:00288 + pyrroloquinoline quinone + + A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone. + + 18315 + ChEBI + + + 1310505 + PubMed + + + 7665488 + PubMed + + + AA0283 + RESID + + + Cross-link 2. + + 2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone + RESID-alternate + + + 2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione + RESID-alternate + + + 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid + RESID-systematic + + + coenzyme PQQ + RESID-alternate + + + CROSSLNK Pyrroloquinoline quinone (Glu-Tyr) + UniProt-feature + + + methoxatin + RESID-alternate + + + pyrroloquinoline quinone + RESID-name + + + + DiffAvg + 37.92 + + + + DiffFormula + C 0 H -10 N 0 O 3 + + + + DiffMono + 37.906494 + + + + Formula + C 14 H 6 N 2 O 8 + + + + MassAvg + 330.21 + + + + MassMono + 330.012415 + + + + Origin + E, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00906 + MOD:00919 + PSI-MOD + + + MOD:00289 + tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide. + + 9836629 + PubMed + + + AA0284 + RESID + + + Cross-link 4. + + METAL Iron-sulfur (4Fe-4S) + UniProt-feature + + + METAL Iron-sulfur (4Fe-4S); via tele nitrogen + UniProt-feature + + + tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron) + RESID-systematic + + + tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide + RESID-name + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.597831 + + + + FormalCharge + 2- + + + + Formula + C 15 Fe 4 H 18 N 6 O 4 S 7 + + + + MassAvg + 794.15 + + + + MassMono + 793.684297 + + + + Origin + C, C, C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00290 + tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide. + + 7854413 + PubMed + + + AA0285 + RESID + + + Cross-link 4. + + METAL Iron-sulfur (4Fe-4S) + UniProt-feature + + + METAL Iron-sulfur (4Fe-4S); via pros nitrogen + UniProt-feature + + + tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron) + RESID-systematic + + + tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide + RESID-name + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.597831 + + + + FormalCharge + 2- + + + + Formula + C 15 Fe 4 H 18 N 6 O 4 S 7 + + + + MassAvg + 794.15 + + + + MassMono + 793.684297 + + + + Origin + C, C, C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00291 + tris-L-cysteinyl L-aspartato tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide. + + 7819255 + PubMed + + + 9283079 + PubMed + + + AA0286 + RESID + + + Cross-link 4. + + METAL Iron-sulfur (4Fe-4S) + UniProt-feature + + + tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron) + RESID-systematic + + + tris-L-cysteinyl L-aspartato tetrairon tetrasulfide + RESID-name + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.597831 + + + + FormalCharge + 2- + + + + Formula + C 13 Fe 4 H 16 N 4 O 6 S 7 + + + + MassAvg + 772.09 + + + + MassMono + 771.652328 + + + + Origin + C, C, C, D + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00904 + MOD:00905 + PSI-MOD + + + MOD:00292 + N6-pyruvic acid 2-iminyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine. + + 1463470 + PubMed + + + 7853400 + PubMed + + + 9047371 + PubMed + + + AA0287 + RESID + + + 422#K + UniMod + + + + (2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid + RESID-systematic + + + ACT_SITE Schiff-base intermediate with substrate + UniProt-feature + + + N-pyruvic acid 2-iminyl + UniMod-description + + + N6-pyruvic acid 2-iminyl-L-lysine + RESID-name + + + PyruvicAcidIminyl + PSI-MS-label + + + + DiffAvg + 70.05 + + + + DiffFormula + C 3 H 2 N 0 O 2 + + + + DiffMono + 70.005479 + + + + Formula + C 9 H 14 N 2 O 3 + + + + MassAvg + 198.22 + + + + MassMono + 198.100442 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01170 + PSI-MOD + + + MOD:00293 + tris-L-cysteinyl L-serinyl tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide. + + AA0288 + RESID + + + Cross-link 4. + + tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron) + RESID-systematic + + + tris-L-cysteinyl L-serinyl tetrairon tetrasulfide + RESID-name + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.597831 + + + + FormalCharge + 2- + + + + Formula + C 12 Fe 4 H 16 N 4 O 5 S 7 + + + + MassAvg + 744.08 + + + + MassMono + 743.657414 + + + + Origin + C, C, C, S + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00916 + PSI-MOD + + + MOD:00294 + bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide + + A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide. + + AA0289 + RESID + + + Cross-link 4. + + bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide + RESID-name + + + METAL Iron-sulfur (4Fe-4S) + UniProt-feature + + + METAL Iron-sulfur (4Fe-4S); via pros nitrogen + UniProt-feature + + + tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron) + RESID-systematic + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.597831 + + + + FormalCharge + 2- + + + + Formula + C 15 Fe 4 H 18 N 6 O 5 S 6 + + + + MassAvg + 778.09 + + + + MassMono + 777.707141 + + + + Origin + C, C, H, S + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00909 + MOD:00916 + PSI-MOD + + + MOD:00295 + O-octanoyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine. + + 10604470 + PubMed + + + 12716131 + PubMed + + + AA0290 + RESID + + + 426#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(octanoyloxy)propanoic acid + RESID-systematic + + + L-serine octanoate ester + RESID-alternate + + + LIPID O-octanoyl serine + UniProt-feature + + + O-octanoyl-L-serine + RESID-name + + + O-octanoylated L-serine + PSI-MOD-alternate + + + O3-octanoyl-L-serine + RESID-alternate + + + Octanoyl + PSI-MS-label + + + octanoyl + UniMod-description + + + OOctSer + PSI-MOD-label + + + + DiffAvg + 126.20 + + + + DiffFormula + C 8 H 14 N 0 O 1 + + + + DiffMono + 126.104465 + + + + Formula + C 11 H 19 N 1 O 3 + + + + MassAvg + 213.28 + + + + MassMono + 213.136493 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00669 + MOD:00916 + PSI-MOD + + + MOD:00296 + O-D-glucuronosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine. + + 10858503 + PubMed + + + 12716131 + PubMed + + + 7398618 + PubMed + + + AA0291 + RESID + + + 54#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (GlcA) + UniProt-feature + + + Glucuronyl + PSI-MS-label + + + N-glucuronylation + UniMod-description + + + O-D-glucuronosyl-L-serine + RESID-name + + + O3-D-glucuronosyl-L-serine + RESID-alternate + + + + DiffAvg + 176.12 + + + + DiffFormula + C 6 H 8 N 0 O 6 + + + + DiffMono + 176.032088 + + + + Formula + C 9 H 13 N 1 O 8 + + + + MassAvg + 263.20 + + + + MassMono + 263.064116 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00447 + MOD:00916 + PSI-MOD + + + MOD:00297 + tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide + + A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. + + AA0292 + RESID + + + Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + carbon monoxide dehydrogenase nickel-iron cofactor + RESID-alternate + + + hybrid nickel-triiron cluster + RESID-alternate + + + mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron) + RESID-systematic + + + Ni-3Fe-2S-3O cluster + RESID-alternate + + + tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide + RESID-name + + + + DiffAvg + 363.35 + + + + DiffFormula + C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3 + + + + DiffMono + 362.586337 + + + + Formula + C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7 + + + + MassAvg + 1171.28 + + + + MassMono + 1169.767174 + + + + Origin + C, C, C, C, E, E, H + + + + Source + artifact + + + + TermSpec + none + + MOD:00739 + MOD:00741 + MOD:00905 + MOD:00906 + MOD:00909 + PSI-MOD + + + MOD:00298 + tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + + A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. + + 2550436 + PubMed + + + AA0293 + RESID + + + Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + carbon monoxide dehydrogenase nickel-iron cofactor + RESID-alternate + + + hybrid nickel-triiron cluster + RESID-alternate + + + mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron) + RESID-systematic + + + Ni-3Fe-2S-3O cluster + RESID-alternate + + + tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + RESID-name + + + + DiffAvg + 363.35 + + + + DiffFormula + C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3 + + + + DiffMono + 362.586337 + + + + Formula + C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7 + + + + MassAvg + 1129.24 + + + + MassMono + 1127.756609 + + + + Origin + C, C, C, C, E, H, S + + + + Source + artifact + + + + TermSpec + none + + MOD:00739 + MOD:00741 + MOD:00905 + MOD:00906 + MOD:00909 + MOD:00916 + PSI-MOD + + + MOD:00299 + N6-(L-isoaspartyl)-L-lysine (Asn) + + A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia. + + 21862 + ChEBI + + + 0 + DeltaMass + + + 11000116 + PubMed + + + 6503713 + PubMed + + + AA0294 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid + RESID-systematic + + + beta-(N6-lysyl)aspartyl acid + RESID-alternate + + + CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) + UniProt-feature + + + isoaspartyl N6-lysine + RESID-alternate + + + N(epsilon)-(beta-aspartyl)lysine + RESID-alternate + + + N-(beta-Aspartyl)-Lysine (Crosslink) + DeltaMass-label + + + N6-(L-isoaspartyl)-L-lysine + RESID-name + + + XLNK-4Asp-N6Lys(Asn) + PSI-MOD-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 10 H 15 N 3 O 3 + + + + MassAvg + 225.25 + + + + MassMono + 225.111341 + + + + Origin + K, N + + + + Source + natural + + + + TermSpec + none + + MOD:00903 + MOD:00946 + MOD:01929 + PSI-MOD + + + MOD:00300 + L-glutamyl-5-poly(ADP-ribose) + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose). + + 0 + DeltaMass + + + 11246023 + PubMed + + + 15842200 + PubMed + + + 8533153 + PubMed + + + AA0295 + RESID + + + 213#E + UniMod + + + + (S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid + RESID-systematic + + + ADP Ribose addition + UniMod-description + + + ADP-Ribosyl + PSI-MS-label + + + L-glutamyl-5-poly(ADP-ribose) + RESID-name + + + L-isoglutamyl-poly(ADP-ribose) + RESID-alternate + + + MOD_RES PolyADP-ribosyl glutamic acid + UniProt-feature + + + O-ADP-ribosylation (on Glutamate or C terminus) + DeltaMass-label + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 20 H 28 N 6 O 16 P 2 + + + + MassAvg + 670.42 + + + + MassMono + 670.103702 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00906 + PSI-MOD + + + MOD:00301 + O-(N-acetylglucosamine-1-phosphoryl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine. + + 0 + DeltaMass + + + 6438439 + PubMed + + + 6993483 + PubMed + + + 8631906 + PubMed + + + AA0296 + RESID + + + 428 + UniMod + + + + (2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid + RESID-systematic + + + N-acetylglucosamine-1-phosphoryl + UniMod-description + + + O-(N-acetylglucosamine-1-phosphoryl)-L-serine + RESID-name + + + O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine + RESID-alternate + + + O-GlcNAc-1-phosphorylation (of Serine) + DeltaMass-label + + + O3-(N-acetylglucosamine-1-phosphoryl)-L-serine + RESID-alternate + + + O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester + RESID-alternate + + + PhosphoHexNAc + PSI-MS-label + + + + DiffAvg + 283.17 + + + + DiffFormula + C 8 H 14 N 1 O 8 P 1 + + + + DiffMono + 283.045703 + + + + Formula + C 11 H 19 N 2 O 10 P 1 + + + + MassAvg + 370.25 + + + + MassMono + 370.077731 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01804 + PSI-MOD + + + MOD:00302 + O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. + + 10037765 + PubMed + + + 15649890 + PubMed + + + AA0297 + RESID + + + 429 + UniMod + + + + O-(alpha-D-mannosyl-1-phosphoryl)-L-serine + RESID-alternate + + + O-(D-mannose-1-phosphoryl)-L-serine + RESID-name + + + O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine + RESID-systematic + + + O3-(D-mannose-1-phosphoryl)-L-serine + RESID-alternate + + + O3-L-serine alpha-D-mannopyranose 1-phosphodiester + RESID-alternate + + + phosphoglycosyl-D-mannose-1-phosphoryl + UniMod-description + + + PhosphoHex + PSI-MS-label + + + + DiffAvg + 242.12 + + + + DiffFormula + C 6 H 11 N 0 O 8 P 1 + + + + DiffMono + 242.019154 + + + + Formula + C 9 H 16 N 1 O 10 P 1 + + + + MassAvg + 329.20 + + + + MassMono + 329.051182 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01804 + PSI-MOD + + + MOD:00303 + heptakis-L-histidino tetracopper mu4-sulfide hydroxide + + A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide. + + 11024061 + PubMed + + + 11041839 + PubMed + + + AA0298 + RESID + + + Cross-link 7. + + heptakis-L-histidino tetracopper mu4-sulfide hydroxide + RESID-name + + + mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper) + RESID-systematic + + + nitrous oxide reductase nosZ CuZ cluster + RESID-alternate + + + pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide + RESID-alternate + + + + DiffAvg + 296.19 + + + + DiffFormula + C 0 Cu 4 H -6 N 0 O 1 S 1 + + + + DiffMono + 293.638425 + + + + Formula + C 42 Cu 4 H 43 N 21 O 8 S 1 + + + + MassAvg + 1256.19 + + + + MassMono + 1253.050808 + + + + Origin + H, H, H, H, H, H, H + + + + Source + natural + + + + TermSpec + none + + MOD:00742 + MOD:00860 + MOD:00909 + PSI-MOD + + + MOD:00304 + L-leucine methyl ester + + A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester. + + 10191253 + PubMed + + + 11875433 + PubMed + + + 8206937 + PubMed + + + AA0299 + RESID + + + 34#C-term + UniMod + + + incidental to RESID:AA0039 + PSI-MOD-slim + + 2-amino-4-methylpentanoic methyl ester + RESID-alternate + + + alpha-aminoisocaproic methyl ester + RESID-alternate + + + L-leucine methyl ester + RESID-name + + + Methyl + PSI-MS-label + + + methyl (2S)-2-amino-4-methylpentanoate + RESID-systematic + + + methyl esterified L-leucine + PSI-MOD-alternate + + + methyl L-leucinate + RESID-alternate + + + Methylation + UniMod-description + + + MOD_RES Leucine methyl ester + UniProt-feature + + + OMeLeu + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 14 N 1 O 2 + + + + MassAvg + 144.19 + + + + MassMono + 144.102454 + + + + Origin + L + + + + Source + natural + + + + TermSpec + C-term + + MOD:00599 + MOD:00662 + MOD:01689 + PSI-MOD + + + MOD:00305 + hexakis-L-cysteinyl L-serinyl octairon heptasulfide + + A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide. + + 10525412 + PubMed + + + 12215645 + PubMed + + + 9063865 + PubMed + + + AA0300 + RESID + + + Cross-link 7; incidental to RESID:AA0141. + + Cys6Ser-[8Fe7S] + PSI-MOD-label + + + hexakis-L-cysteinyl L-serinyl octairon heptasulfide + RESID-name + + + METAL Iron-sulfur (8Fe-7S) + UniProt-feature + + + nitrogenase P-cluster + RESID-alternate + + + + DiffAvg + 663.12 + + + + DiffFormula + C 0 Fe 8 H -8 N 0 O 0 S 7 + + + + DiffMono + 663.223042 + + + + FormalCharge + 3- + + + + Formula + C 21 Fe 8 H 27 N 7 O 8 S 13 + + + + MassAvg + 1369.03 + + + + MassMono + 1368.310179 + + + + Origin + C, C, C, C, C, C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00916 + PSI-MOD + + + MOD:00306 + residues isobaric at 113.084064 Da + + Natural or modified residues with a mass of 113.084064 Da. + + 10523135 + PubMed + + + AA0301 + RESID + + + PSI-MOD-slim + + L-isoleucine or L-leucine + RESID-name + + + Xle + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00569 + MOD:00624 + PSI-MOD + + + MOD:00307 + L-aspartimide + + A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide. + + 18 + DeltaMass + + + 12771378 + PubMed + + + 2378679 + PubMed + + + 7662664 + PubMed + + + 7988548 + PubMed + + + 9309583 + PubMed + + + AA0302 + RESID + + + 23#N + UniMod + + + From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956. + + (3S)-3-amino-2,5-pyrrolidinedione + RESID-systematic + + + 2-amino-butanimide + RESID-alternate + + + alpha-aminosuccinimide + RESID-alternate + + + ASI + RESID-alternate + + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + L-2-aminosuccinimide + RESID-alternate + + + L-3-aminosuccinimide + RESID-misnomer + + + L-asparaginimide + RESID-alternate + + + L-aspartimide + RESID-name + + + Succinimide formation from asparagine + DeltaMass-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 4 H 5 N 2 O 2 + + + + MassAvg + 113.10 + + + + MassMono + 113.035102 + + + + Origin + N + + + + Source + natural + + + + TermSpec + C-term + + MOD:00601 + MOD:00704 + MOD:00903 + PSI-MOD + + + MOD:00308 + L-glutamimide + + A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide. + + 12771378 + PubMed + + + 14593103 + PubMed + + + AA0303 + RESID + + + 23#Q + UniMod + + + + (3S)-3-aminopiperidine-2,6-dione + RESID-systematic + + + 2-aminopentanimide + RESID-alternate + + + 3-amino-2,6-piperidinedione + RESID-alternate + + + alpha-aminoglutarimide + RESID-alternate + + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + L-glutamimide + RESID-name + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 7 N 2 O 2 + + + + MassAvg + 127.12 + + + + MassMono + 127.050752 + + + + Origin + Q + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00601 + MOD:00704 + MOD:00907 + PSI-MOD + + + MOD:00309 + L-beta-carboxyaspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid. + + 6390094 + PubMed + + + 7138832 + PubMed + + + 7457858 + PubMed + + + 8135347 + PubMed + + + AA0304 + RESID + + + 299#D + UniMod + + + References to this modification as a gamma-carboxylation are in error [JSG]. + + (2S)-2-aminoethane-1,1,2-tricarboxylic acid + RESID-systematic + + + 2-amino-3-carboxybutanedioic acid + RESID-alternate + + + 3-carboxy-L-aspartic acid + RESID-name + + + 3-carboxyaspartic acid + RESID-alternate + + + 3CbxAsp + PSI-MOD-label + + + beta-carboxyaspartic acid + RESID-alternate + + + Carboxy + PSI-MS-label + + + Carboxy + UniMod-interim + + + Carboxylation + UniMod-description + + + gammacarboxyld + OMSSA-label + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 + + + + DiffMono + 43.989829 + + + + Formula + C 5 H 5 N 1 O 5 + + + + MassAvg + 159.10 + + + + MassMono + 159.016772 + + + + Origin + D + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00904 + MOD:01152 + PSI-MOD + + + MOD:00310 + N5-methyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine. + + 11875433 + PubMed + + + 9792625 + PubMed + + + 9873020 + PubMed + + + AA0305 + RESID + + + + (2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid + RESID-systematic + + + delta-N-methylarginine + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N5-methylarginine + UniProt-feature + + + N5-carbamimidoyl-N5-methyl-L-ornithine + RESID-alternate + + + N5-methyl-L-arginine + RESID-name + + + N5-methylated L-arginine + PSI-MOD-alternate + + + N5Me1Arg + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 14 N 4 O 1 + + + + MassAvg + 170.22 + + + + MassMono + 170.116761 + + + + Origin + R + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00414 + MOD:00602 + PSI-MOD + + + MOD:00311 + L-cysteine coenzyme A disulfide + + A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide. + + 0 + DeltaMass + + + 1734967 + PubMed + + + AA0306 + RESID + + + 281#C + UniMod + + + DeltaMass gives no formula with mass as 454. + + (2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) + RESID-systematic + + + coenzyme A L-cysteine mixed disulfide + RESID-alternate + + + CoenzymeA + PSI-MS-label + + + Cysteine modified Coenzyme A + UniMod-description + + + L-cysteine coenzyme A disulfide + RESID-name + + + SCoACys + PSI-MOD-label + + + + DiffAvg + 765.52 + + + + DiffFormula + C 21 H 34 N 7 O 16 P 3 S 1 + + + + DiffMono + 765.099559 + + + + Formula + C 24 H 39 N 8 O 17 P 3 S 2 + + + + MassAvg + 868.66 + + + + MassMono + 868.108744 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00861 + MOD:00905 + MOD:01862 + PSI-MOD + + + MOD:00312 + S-myristoyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine. + + 10026218 + PubMed + + + 10080938 + PubMed + + + 8824274 + PubMed + + + AA0307 + RESID + + + 45#C + UniMod + + + + (R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid + RESID-systematic + + + LIPID S-myristoyl cysteine + UniProt-feature + + + Myristoyl + PSI-MS-label + + + Myristoylation + UniMod-description + + + S-(C14:1 aliphatic acyl)cysteine + PSI-MOD-alternate + + + S-myristoyl-L-cysteine + RESID-name + + + S-myristoylated L-cysteine + PSI-MOD-alternate + + + SMyrCys + PSI-MOD-label + + + tetradecanoate cysteine thioester + RESID-alternate + + + + DiffAvg + 210.36 + + + + DiffFormula + C 14 H 26 N 0 O 1 S 0 + + + + DiffMono + 210.198365 + + + + Formula + C 17 H 31 N 1 O 2 S 1 + + + + MassAvg + 313.50 + + + + MassMono + 313.207550 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00655 + MOD:00905 + PSI-MOD + + + MOD:00313 + S-palmitoleyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine. + + 8294460 + PubMed + + + AA0308 + RESID + + + 431#C + UniMod + + + + (R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid + RESID-systematic + + + cis-9-hexadecenoate cysteine thioester + RESID-alternate + + + mod187 + OMSSA-label + + + Palmitoleyl + PSI-MS-label + + + palmitoleyl + UniMod-description + + + S-palmitoleyl-L-cysteine + RESID-name + + + S-palmitoleylated L-cysteine + PSI-MOD-alternate + + + SPamD1Cys + PSI-MOD-label + + + + DiffAvg + 236.40 + + + + DiffFormula + C 16 H 28 N 0 O 1 S 0 + + + + DiffMono + 236.214016 + + + + Formula + C 19 H 33 N 1 O 2 S 1 + + + + MassAvg + 339.54 + + + + MassMono + 339.223200 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00672 + MOD:00905 + MOD:01423 + PSI-MOD + + + MOD:00314 + glycine cholesterol ester + + A protein modification that effectively converts a glycine residue to glycine cholesterol ester. + + 11111088 + PubMed + + + 8824192 + PubMed + + + AA0309 + RESID + + + 432#C-term + UniMod + + + Incidental to RESID:AA0060. UniMod origin corrected [JSG]. + PSI-MOD-slim + + C-cholesterol + UniMod-interim + + + cholesterol ester + UniMod-description + + + cholesteryl glycinate + RESID-alternate + + + glycine cholest-5-en-3beta-ol ester + RESID-systematic + + + glycine cholesterol ester + RESID-name + + + hedgehog lipophilic adduct + RESID-alternate + + + LIPID Cholesterol glycine ester + UniProt-feature + + + + DiffAvg + 368.65 + + + + DiffFormula + C 27 H 44 N 0 O 0 + + + + DiffMono + 368.344301 + + + + Formula + C 29 H 48 N 1 O 2 + + + + MassAvg + 442.71 + + + + MassMono + 442.368505 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:00908 + MOD:01155 + PSI-MOD + + + MOD:00315 + pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide + + A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide. + + 11509720 + PubMed + + + 2550436 + PubMed + + + AA0310 + RESID + + + Cross-link 6. + + carbon monoxide dehydrogenase nickel-iron cofactor + RESID-alternate + + + METAL Nickel-iron-sulfur (Ni-4Fe-5S) + UniProt-feature + + + METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen + UniProt-feature + + + mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron) + RESID-systematic + + + Ni-4Fe-5S cluster + RESID-alternate + + + pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide + RESID-name + + + + DiffAvg + 436.33 + + + + DiffFormula + C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5 + + + + DiffMono + 435.488498 + + + + Formula + C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10 + + + + MassAvg + 1089.16 + + + + MassMono + 1087.593333 + + + + Origin + C, C, C, C, C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00741 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00316 + N4,N4-dimethyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine. + + 12964758 + PubMed + + + 14570711 + PubMed + + + 8783012 + PubMed + + + AA0311 + RESID + + + 36#N + UniMod + + + + (2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid + RESID-systematic + + + 2-amino-N4,N4-dimethylbutanediamic acid + RESID-alternate + + + beta-dimethylasparagine + RESID-misnomer + + + di-Methylation + UniMod-description + + + Dimethyl + PSI-MS-label + + + MOD_RES N4,N4-dimethylasparagine + UniProt-feature + + + N(gamma),N(gamma)-dimethylasparagine + RESID-alternate + + + N4,N4-dimethyl-L-asparagine + RESID-name + + + N4,N4-dimethylated L-asparagine + PSI-MOD-alternate + + + N4Me2Asn + PSI-MOD-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 6 H 10 N 2 O 2 + + + + MassAvg + 142.16 + + + + MassMono + 142.074228 + + + + Origin + N + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00429 + MOD:00602 + MOD:00673 + PSI-MOD + + + MOD:00317 + N6-3,4-didehydroretinylidene-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine. + + 10717661 + PubMed + + + 3257009 + PubMed + + + 4056688 + PubMed + + + AA0312 + RESID + + + 433#K + UniMod + + + + (S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid + RESID-systematic + + + 3,4-didehydroretinylidene + UniMod-description + + + Didehydroretinylidene + PSI-MS-label + + + N6-(3,4-didehydroretinylidene)-L-lysine + RESID-name + + + N6-3-dehydroretinal-L-lysine + RESID-alternate + + + N6-3-dehydroretinyl-lysine + RESID-alternate + + + + DiffAvg + 264.41 + + + + DiffFormula + C 20 H 24 N 0 O 0 + + + + DiffMono + 264.187801 + + + + Formula + C 26 H 36 N 2 O 1 + + + + MassAvg + 392.59 + + + + MassMono + 392.282764 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + MOD:00318 + 4'-(S-L-cysteinyl)-L-tryptophyl quinone + + A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone. + + 11555656 + PubMed + + + 11717396 + PubMed + + + AA0313 + RESID + + + Cross-link 2; secondary to RESID:AA0148. + + (2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid + RESID-systematic + + + 3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione + RESID-alternate + + + 4'-(L-cystein-S-yl)-L-tryptophyl quinone + RESID-name + + + 4-(S-cysteinyl)tryptophan-6,7-dione + RESID-alternate + + + CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp) + UniProt-feature + + + CTQ + RESID-alternate + + + cysteine tryptophylquinone + RESID-alternate + + + + DiffAvg + 27.97 + + + + DiffFormula + C 0 H -4 N 0 O 2 S 0 + + + + DiffMono + 27.958529 + + + + Formula + C 14 H 11 N 3 O 4 S 1 + + + + MassAvg + 317.32 + + + + MassMono + 317.047027 + + + + Origin + C, W + + + + Source + natural + + + + TermSpec + none + + MOD:00687 + MOD:00918 + PSI-MOD + + + MOD:00319 + 3-(S-L-cysteinyl)-L-aspartic acid + + A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid. + + 11555656 + PubMed + + + 11717396 + PubMed + + + AA0314 + RESID + + + Cross-link 2. + + (2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid + RESID-systematic + + + (2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid + RESID-alternate + + + 3-(L-cystein-S-yl)-L-aspartic acid + RESID-name + + + 3-carboxy-L-lanthionine + RESID-alternate + + + CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 7 H 8 N 2 O 4 S 1 + + + + MassAvg + 216.21 + + + + MassMono + 216.020478 + + + + Origin + C, D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01993 + PSI-MOD + + + MOD:00320 + 4-(S-L-cysteinyl)-L-glutamic acid + + A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid. + + 20293 + ChEBI + + + 11555656 + PubMed + + + 11717396 + PubMed + + + AA0315 + RESID + + + Cross-link 2. + + (2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid + RESID-alternate + + + (2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid + RESID-systematic + + + 4-(L-cystein-S-yl)-L-glutamic acid + RESID-name + + + CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 8 H 10 N 2 O 4 S 1 + + + + MassAvg + 230.24 + + + + MassMono + 230.036128 + + + + Origin + C, E + + + + Source + natural + + + + TermSpec + none + + MOD:00687 + MOD:00906 + PSI-MOD + + + MOD:00321 + cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester + + A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester. + + 11435437 + PubMed + + + 7949339 + PubMed + + + AA0316 + RESID + + + 434#D + UniMod + + + + (7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid + RESID-systematic + + + barley lipid transfer protein modification + RESID-alternate + + + CHDH + PSI-MS-label + + + cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester + RESID-name + + + cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester + UniMod-description + + + LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester + UniProt-feature + + + + DiffAvg + 294.39 + + + + DiffFormula + C 17 H 26 N 0 O 4 + + + + DiffMono + 294.183109 + + + + Formula + C 21 H 31 N 1 O 7 + + + + MassAvg + 409.48 + + + + MassMono + 409.210052 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01155 + PSI-MOD + + + MOD:00322 + 1'-methyl-L-histidine + + A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine. + + 10601317 + PubMed + + + 11474090 + PubMed + + + 11875433 + PubMed + + + 6692818 + PubMed + + + 8076 + PubMed + + + 8645219 + PubMed + + + AA0317 + RESID + + + PSI-MOD-slim + + (S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid + RESID-systematic + + + 1'-methyl-L-histidine + RESID-name + + + 3-methylhistidine + RESID-misnomer + + + 4-methyl-histidine + RESID-misnomer + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES Tele-methylhistidine + UniProt-feature + + + N(epsilon)-methylhistidine + RESID-alternate + + + N(tau)-methylhistidine + RESID-alternate + + + NteleMeHis + PSI-MOD-label + + + tele-methylated L-histidine + PSI-MOD-alternate + + + tele-methylhistidine + RESID-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 9 N 3 O 1 + + + + MassAvg + 151.17 + + + + MassMono + 151.074562 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00724 + PSI-MOD + + + MOD:00323 + L-lysine methyl ester + + A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester. + + 10973948 + PubMed + + + 11875433 + PubMed + + + AA0318 + RESID + + + 34#C-term + UniMod + + + PSI-MOD-slim + + 2,6-diaminohexanoic methyl ester + RESID-alternate + + + alpha,epsilon-diaminocaproic methyl ester + RESID-alternate + + + L-lysine methyl ester + RESID-name + + + Methyl + PSI-MS-label + + + methyl (S)-2,6-diaminohexanoate + RESID-systematic + + + methyl esterified L-lysine + PSI-MOD-alternate + + + methyl L-lysinate + RESID-alternate + + + Methylation + UniMod-description + + + MOD_RES Lysine methyl ester + UniProt-feature + + + OMeLys + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 15 N 2 O 2 + + + + MassAvg + 159.21 + + + + MassMono + 159.113353 + + + + Origin + K + + + + Source + natural + + + + TermSpec + C-term + + MOD:01683 + MOD:01689 + PSI-MOD + + + MOD:00324 + L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) + + A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide). + + 8658132 + PubMed + + + 8658134 + PubMed + + + AA0319 + RESID + + + + 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide + RESID-alternate + + + bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide + RESID-systematic + + + L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) + RESID-name + + + + DiffAvg + 1588.01 + + + + DiffFormula + C 40 H 47 Mo 1 N 20 O 27 P 4 S 4 + + + + DiffMono + 1588.980690 + + + + Formula + C 43 H 52 Mo 1 N 21 O 29 P 4 S 4 + + + + MassAvg + 1675.09 + + + + MassMono + 1676.012718 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00744 + MOD:00916 + PSI-MOD + + + MOD:00325 + L-beta-methylthioasparagine + + A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine. + + AA0320 + RESID + + + 39#N + UniMod + + + This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid + RESID-systematic + + + 2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid + RESID-alternate + + + 3-(methylthio)-L-asparagine + RESID-name + + + 3-carboxamido-S-methyl-cysteine + RESID-alternate + + + beta-(methylthio)asparagine + RESID-alternate + + + Beta-methylthiolation + UniMod-description + + + Methylthio + UniMod-interim + + + + DiffAvg + 46.09 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 1 + + + + DiffMono + 45.987721 + + + + Formula + C 5 H 8 N 2 O 2 S 1 + + + + MassAvg + 160.19 + + + + MassMono + 160.030649 + + + + Origin + N + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00903 + MOD:01153 + PSI-MOD + + + MOD:00326 + L-pyrrolysine (Lys) + + A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process). + + 11435424 + PubMed + + + 12029131 + PubMed + + + 12029132 + PubMed + + + 15314242 + PubMed + + + 16096277 + PubMed + + + AA0321#LYS + RESID + + + 435#K + UniMod + + + This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG]. + + (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid + RESID-systematic + + + 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid + RESID-alternate + + + L-pyrrolysine + RESID-name + + + monomethylamine methyltransferase cofactor lysine adduct + RESID-alternate + + + N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine + RESID-alternate + + + N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine + RESID-alternate + + + N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine + RESID-alternate + + + NON_STD Pyrrolysine + UniProt-feature + + + Pyl(Lys) + PSI-MOD-label + + + + DiffAvg + 109.13 + + + + DiffFormula + C 6 H 7 N 1 O 1 + + + + DiffMono + 109.052764 + + + + Formula + C 12 H 19 N 3 O 2 + + + + MassAvg + 237.30 + + + + MassMono + 237.147727 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01187 + PSI-MOD + + + MOD:00327 + 3-hydroxy-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan. + + 10024453 + PubMed + + + 11457355 + PubMed + + + AA0322 + RESID + + + + (2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid + RESID-systematic + + + 3-hydroxy-L-tryptophan + RESID-name + + + 3-hydroxylated L-tryptophan + PSI-MOD-alternate + + + 3-hydroxytryptophan + RESID-alternate + + + 3HyTrp + PSI-MOD-label + + + beta-hydroxytryptophan + RESID-alternate + + + MOD_RES 3-hydroxytryptophan + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 11 H 10 N 2 O 2 + + + + MassAvg + 202.21 + + + + MassMono + 202.074228 + + + + Origin + W + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01622 + PSI-MOD + + + MOD:00328 + O4'-(phospho-3'-DNA)-L-tyrosine + + A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine. + + 2211714 + PubMed + + + AA0323 + RESID + + + + (S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid + RESID-systematic + + + ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate + UniProt-feature + + + O4'-(phospho-3'-DNA)-L-tyrosine + RESID-name + + + O4'-L-tyrosine 3'-DNA phosphodiester + RESID-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 9 H 10 N 1 O 5 P 1 + + + + MassAvg + 243.15 + + + + MassMono + 243.029659 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00750 + MOD:00919 + PSI-MOD + + + MOD:00329 + hydroxyheme-L-glutamate ester + + A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 11139583 + PubMed + + + 11821421 + PubMed + + + 11980497 + PubMed + + + AA0324 + RESID + + + 436#E + UniMod + + + + 5-hydroxymethyl protoporphyrin IX 5-glutamate ester + RESID-alternate + + + [3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + BINDING Heme (covalent; via 1 link) + UniProt-feature + + + cytochrome P450 CYP4A family heme cofactor + RESID-alternate + + + Hydroxyheme + PSI-MS-label + + + hydroxyheme + UniMod-description + + + hydroxyheme-L-glutamate ester + RESID-name + + + + DiffAvg + 614.48 + + + + DiffFormula + C 34 Fe 1 H 30 N 4 O 4 + + + + DiffMono + 614.161643 + + + + Formula + C 39 Fe 1 H 37 N 5 O 7 + + + + MassAvg + 743.60 + + + + MassMono + 743.204236 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00699 + MOD:00906 + PSI-MOD + + + MOD:00330 + (phospho-5'-guanosine)-L-histidine + + A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine. + + 10529169 + PubMed + + + 10869342 + PubMed + + + 7559521 + PubMed + + + AA0325 + RESID + + + 413#H + UniMod + + + + (2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid + RESID-systematic + + + 1'-(phospho-5'-guanosine)-L-histidine + RESID-name + + + ACT_SITE GMP-histidine intermediate + UniProt-feature + + + L-histidine 5'-guanosine phosphoramidester + RESID-alternate + + + L-histidine monoanhydride with 5'-guanylic acid + RESID-alternate + + + N(tau)-5'-guanylic-L-histidine + RESID-alternate + + + N1'-guanylylated histidine + RESID-alternate + + + phospho-guanosine + UniMod-description + + + Phosphoguanosine + PSI-MS-label + + + tele-5'-guanylic-L-histidine + RESID-alternate + + + + DiffAvg + 345.21 + + + + DiffFormula + C 10 H 12 N 5 O 7 P 1 + + + + DiffMono + 345.047434 + + + + Formula + C 16 H 19 N 8 O 8 P 1 + + + + MassAvg + 482.35 + + + + MassMono + 482.106346 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + MOD:01163 + PSI-MOD + + + MOD:00331 + tetrakis-L-cysteinyl triiron tetrasulfide + + A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide. + + 11592901 + PubMed + + + 11941493 + PubMed + + + 2511202 + PubMed + + + 6094558 + PubMed + + + AA0326 + RESID + + + Cross-link 4. + + bis[bis-L-cysteinyl iron disulfido]iron + RESID-alternate + + + di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron) + RESID-systematic + + + tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron + RESID-alternate + + + tetrakis-L-cysteinyl linear [3Fe-4S] cluster + RESID-alternate + + + tetrakis-L-cysteinyl triiron tetrasulfide + RESID-name + + + tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster + RESID-alternate + + + + DiffAvg + 291.74 + + + + DiffFormula + C 0 Fe 3 H -4 N 0 O 0 S 4 + + + + DiffMono + 291.663442 + + + + FormalCharge + 3- + + + + Formula + C 12 Fe 3 H 16 N 4 O 4 S 8 + + + + MassAvg + 704.30 + + + + MassMono + 703.700181 + + + + Origin + C, C, C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00332 + omega-N-glucosyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine. + + 15279557 + PubMed + + + 8521968 + PubMed + + + 9536051 + PubMed + + + AA0327 + RESID + + + 41#R + UniMod + + + + (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid + RESID-systematic + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + NG-beta-D-glucosylarginine + RESID-alternate + + + omega-N-(beta-D-glucosyl)-L-arginine + RESID-alternate + + + omega-N-glucosyl-L-arginine + RESID-name + + + omega-N-glycosyl-L-arginine + RESID-alternate + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 12 H 22 N 4 O 6 + + + + MassAvg + 318.33 + + + + MassMono + 318.153934 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00433 + MOD:00761 + MOD:01980 + PSI-MOD + + + MOD:00333 + (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine + + A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine. + + 7559516 + PubMed + + + 7835418 + PubMed + + + 8183363 + PubMed + + + AA0328 + RESID + + + 437#C-term + UniMod + + + UniMod origin shown as C-term [JSG]. + + (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine + RESID-name + + + (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine + UniMod-description + + + 5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine + RESID-systematic + + + 9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine + RESID-alternate + + + C-Asn-deriv + UniMod-interim + + + microcin C7 asparagine modification + RESID-alternate + + + MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide + UniProt-feature + + + N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide + RESID-alternate + + + + DiffAvg + 386.30 + + + + DiffFormula + C 13 H 19 N 6 O 6 P 1 + + + + DiffMono + 386.110369 + + + + Formula + C 17 H 26 N 8 O 9 P 1 + + + + MassAvg + 517.42 + + + + MassMono + 517.156036 + + + + Origin + N + + + + Source + natural + + + + TermSpec + C-term + + MOD:00701 + MOD:00903 + PSI-MOD + + + MOD:00334 + 1'-heme-L-histidine + + A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. + + 12033922 + PubMed + + + 12121092 + PubMed + + + AA0329 + RESID + + + 390#H + UniMod + + + + (S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate + RESID-systematic + + + 1'-heme-L-histidine + RESID-name + + + 2-[1-(N1'-histidyl)ethyl]protoporphyrin IX + RESID-alternate + + + BINDING Heme (covalent; via tele nitrogen) + UniProt-feature + + + Heme + PSI-MS-label + + + heme + UniMod-description + + + N(epsilon)-histidyl heme + RESID-alternate + + + N(tau)-histidyl heme + RESID-alternate + + + N1'-histidyl heme + RESID-alternate + + + tele-histidyl heme + RESID-alternate + + + + DiffAvg + 616.50 + + + + DiffFormula + C 34 Fe 1 H 32 N 4 O 4 + + + + DiffMono + 616.177293 + + + + Formula + C 40 Fe 1 H 39 N 7 O 5 + + + + MassAvg + 753.64 + + + + MassMono + 753.236205 + + + + Origin + H + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00699 + MOD:00909 + PSI-MOD + + + MOD:00335 + (2S,3S,2'R)-3-methyllanthionine sulfoxide + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide. + + 7737178 + PubMed + + + 9219543 + PubMed + + + AA0330 + RESID + + + Cross-link 2. + + (2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid + RESID-alternate + + + (2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid + RESID-systematic + + + 3-methyl-L-lanthionine S-oxide + RESID-alternate + + + 3-methyl-L-lanthionine sulfoxide + RESID-name + + + CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys) + UniProt-feature + + + S-oxy-3-methyllanthionine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 7 H 10 N 2 O 3 S 1 + + + + MassAvg + 202.23 + + + + MassMono + 202.041213 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01993 + + has_functional_parent + MOD:019810 + + PSI-MOD + + + MOD:00336 + tris-L-cysteinyl L-aspartato diiron disulfide + + A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide. + + 10968624 + PubMed + + + 1312028 + PubMed + + + 7947772 + PubMed + + + AA0331 + RESID + + + Cross-link 4. + + di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron) + RESID-systematic + + + METAL Iron-sulfur (2Fe-2S) + UniProt-feature + + + tris-L-cysteinyl L-aspartato diiron disulfide + RESID-name + + + + DiffAvg + 171.78 + + + + DiffFormula + C 0 Fe 2 H -4 N 0 O 0 S 2 + + + + DiffMono + 171.783814 + + + + FormalCharge + 2- + + + + Formula + C 13 Fe 2 H 16 N 4 O 6 S 5 + + + + MassAvg + 596.28 + + + + MassMono + 595.838311 + + + + Origin + C, C, C, D + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00904 + MOD:00905 + PSI-MOD + + + MOD:00337 + S-carbamoyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine. + + 12586941 + PubMed + + + 240389 + PubMed + + + AA0332 + RESID + + + 5#C + UniMod + + + + (R)-2-amino-3-(carbamoylsulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(aminocarbonyl)sulfanylpropanoic acid + RESID-alternate + + + 2-amino-3-(aminocarbonyl)thiopropanoic acid + RESID-alternate + + + alpha-amino-beta-carbamylthiopropionic acid + RESID-alternate + + + beta-carbamylthioalanine + RESID-alternate + + + MOD_RES S-carbamoylcysteine + UniProt-feature + + + S-(aminocarbonyl)cysteine + RESID-alternate + + + S-carbamoyl-L-cysteine + RESID-name + + + S-carbamoylcysteine + RESID-alternate + + + S-carbamylcysteine + RESID-alternate + + + S-cysteinyl carbamate ester + RESID-alternate + + + SCbmCys + PSI-MOD-label + + + + DiffAvg + 43.02 + + + + DiffFormula + C 1 H 1 N 1 O 1 S 0 + + + + DiffMono + 43.005814 + + + + Formula + C 4 H 6 N 2 O 2 S 1 + + + + MassAvg + 146.16 + + + + MassMono + 146.014998 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00398 + MOD:00905 + PSI-MOD + + + MOD:00338 + S-cyano-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine. + + 12586941 + PubMed + + + 4808702 + PubMed + + + AA0333 + RESID + + + 438#C + UniMod + + + + (2R)-2-amino-3-thiocyanatopropanoic acid + RESID-systematic + + + alpha-amino-beta-thiocyanatopropionic acid + RESID-alternate + + + beta-thiocyanatoalanine + RESID-alternate + + + Cyano + PSI-MS-label + + + cyano + UniMod-description + + + MOD_RES S-cyanocysteine + UniProt-feature + + + S-cyano-L-cysteine + RESID-name + + + S-cyanocysteine + RESID-alternate + + + serine thiocyanic acid ester + RESID-alternate + + + + DiffAvg + 25.01 + + + + DiffFormula + C 1 H -1 N 1 O 0 S 0 + + + + DiffMono + 24.995249 + + + + Formula + C 4 H 4 N 2 O 1 S 1 + + + + MassAvg + 128.15 + + + + MassMono + 128.004434 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00893 + MOD:00905 + PSI-MOD + + + MOD:00339 + L-cysteinyl hydrogenase diiron subcluster + + A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster. + + 10694885 + PubMed + + + 9836629 + PubMed + + + AA0334 + RESID + + + 439#C + UniMod + + + incidental to RESID:AA0140. + + 1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile + RESID-alternate + + + Diironsubcluster + PSI-MS-label + + + hydrogenase diiron subcluster + UniMod-description + + + L-cysteinyl hydrogenase diiron subcluster + RESID-name + + + METAL Diiron subcluster + UniProt-feature + + + mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron + RESID-systematic + + + + DiffAvg + 342.87 + + + + DiffFormula + C 5 Fe 2 H -1 N 2 O 5 S 2 + + + + DiffMono + 342.786913 + + + + Formula + C 8 Fe 2 H 4 N 3 O 6 S 3 + + + + MassAvg + 446.01 + + + + MassMono + 445.796098 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00738 + MOD:00905 + PSI-MOD + + + MOD:00340 + S-amidino-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine. + + 9148748 + PubMed + + + AA0335 + RESID + + + 440#C + UniMod + + + + (2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-amidinosulfanylpropanoic acid + RESID-alternate + + + 2-amino-3-amidinothiopropanoic acid + RESID-alternate + + + ACT_SITE Amidino-cysteine intermediate + UniProt-feature + + + alpha-amino-beta-amidinothiopropionic acid + RESID-alternate + + + Amidino + PSI-MS-label + + + amidino + UniMod-description + + + beta-(S-isothiourea)alanine + RESID-alternate + + + beta-amidinothioalanine + RESID-alternate + + + S-amidino-L-cysteine + RESID-name + + + S-amidinocysteine + RESID-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 1 H 2 N 2 O 0 S 0 + + + + DiffMono + 42.021798 + + + + Formula + C 4 H 7 N 3 O 1 S 1 + + + + MassAvg + 145.18 + + + + MassMono + 145.030983 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00341 + N-methyl-L-isoleucine + + A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine. + + 11875433 + PubMed + + + AA0336 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + + (2S,3S)-2-methylamino-3-methylpentanoic acid + RESID-systematic + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N-methylisoleucine + UniProt-feature + + + N-methyl-L-isoleucine + RESID-name + + + N-methylated L-isoleucine + PSI-MOD-alternate + + + N-methylisoleucine + RESID-alternate + + + NMe1Ile + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 13 N 1 O 1 + + + + MassAvg + 127.19 + + + + MassMono + 127.099714 + + + + Origin + I + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00715 + MOD:01680 + PSI-MOD + + + MOD:00342 + N-methyl-L-leucine + + A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine. + + 11875433 + PubMed + + + AA0337 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + + (S)-2-methylamino-4-methylpentanoic acid + RESID-systematic + + + 2-(methylamino)-4-methyl-valeric acid + RESID-alternate + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + MOD_RES N-methylleucine + UniProt-feature + + + N-methyl-L-leucine + RESID-name + + + N-methylated L-leucine + PSI-MOD-alternate + + + N-methylleucine + RESID-alternate + + + NMe1Leu + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 13 N 1 O 1 + + + + MassAvg + 127.19 + + + + MassMono + 127.099714 + + + + Origin + L + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01680 + MOD:01808 + PSI-MOD + + + MOD:00343 + N-methyl-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine. + + 0 + DeltaMass + + + AA0338 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + + (2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid + RESID-systematic + + + Methyl + PSI-MS-label + + + MOD_RES N-methyltyrosine + UniProt-feature + + + N-methyl Tyrosinyl + DeltaMass-label + + + N-methyl-L-tyrosine + RESID-name + + + N-methylated L-tyrosine + PSI-MOD-alternate + + + N-methyltyrosine + RESID-alternate + + + NMe1Tyr + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 10 H 11 N 1 O 2 + + + + MassAvg + 177.20 + + + + MassMono + 177.078979 + + + + Origin + Y + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00718 + MOD:01680 + PSI-MOD + + + MOD:00344 + N-palmitoylglycine + + A protein modification that effectively converts a glycine residue to N-palmitoylglycine. + + 12574119 + PubMed + + + AA0339 + RESID + + + incidental to RESID:AA0060 + PSI-MOD-slim + + (hexadecanamido)acetic acid + RESID-alternate + + + (hexadecanoylamino)acetic acid + RESID-alternate + + + (hexadecanoylamino)ethanoic acid + RESID-systematic + + + LIPID N-palmitoyl glycine + UniProt-feature + + + N-(1-oxohexadecyl)glycine + RESID-alternate + + + N-palmitoyl-glycine + RESID-name + + + N-palmitoylated glycine + PSI-MOD-alternate + + + NPamGly + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + C 18 H 34 N 1 O 2 + + + + MassAvg + 296.47 + + + + MassMono + 296.258954 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00908 + MOD:01685 + PSI-MOD + + + MOD:00345 + 2-(S-L-cysteinyl)-L-phenylalanine + + A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine. + + 12696888 + PubMed + + + 3936839 + PubMed + + + AA0340 + RESID + + + Cross-link 2. + + (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid + RESID-systematic + + + (2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid + RESID-alternate + + + 2-(L-cystein-S-yl)-L-phenylalanine + RESID-name + + + alpha-(L-cystein-S-yl)-L-phenylalanine + RESID-alternate + + + CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 12 H 12 N 2 O 2 S 1 + + + + MassAvg + 248.30 + + + + MassMono + 248.061949 + + + + Origin + C, F + + + + Source + natural + + + + TermSpec + none + + MOD:00914 + MOD:01992 + PSI-MOD + + + MOD:00346 + 2-(S-L-cysteinyl)-D-phenylalanine + + A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine. + + 12696888 + PubMed + + + 3936839 + PubMed + + + AA0341 + RESID + + + Cross-link 2. + + (2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid + RESID-systematic + + + (2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid + RESID-alternate + + + 2-(L-cystein-S-yl)-D-phenylalanine + RESID-name + + + alpha-(L-cystein-S-yl)-D-phenylalanine + RESID-alternate + + + CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 12 H 12 N 2 O 2 S 1 + + + + MassAvg + 248.30 + + + + MassMono + 248.061949 + + + + Origin + C, F + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00914 + MOD:01992 + PSI-MOD + + + MOD:00347 + 2-(S-L-cysteinyl)-D-allo-threonine + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine. + + 12696888 + PubMed + + + 3936839 + PubMed + + + AA0342 + RESID + + + Cross-link 2. + + (2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid + RESID-alternate + + + (2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid + RESID-systematic + + + 2-(L-cystein-S-yl)-D-allo-threonine + RESID-name + + + alpha-(L-cystein-S-yl)-D-allo-threonine + RESID-alternate + + + CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 7 H 10 N 2 O 3 S 1 + + + + MassAvg + 202.23 + + + + MassMono + 202.041213 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00917 + MOD:01992 + PSI-MOD + + + MOD:00348 + N-carbamoyl-L-alanine + + A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine. + + 12203680 + PubMed + + + AA0343 + RESID + + + + (S)-2-(carbamoylamino)propanoic acid + RESID-systematic + + + 2-ureidopropanoic acid + RESID-alternate + + + MOD_RES N-carbamoylalanine + UniProt-feature + + + N-carbamoyl-L-alanine + RESID-name + + + N-carbamylalanine + RESID-alternate + + + N2CbmAla + PSI-MOD-label + + + + DiffAvg + 43.02 + + + + DiffFormula + C 1 H 1 N 1 O 1 + + + + DiffMono + 43.005814 + + + + Formula + C 4 H 7 N 2 O 2 + + + + MassAvg + 115.11 + + + + MassMono + 115.050752 + + + + Origin + A + + + + Source + natural + + + + TermSpec + N-term + + MOD:00901 + MOD:01679 + PSI-MOD + + + MOD:00349 + 4-amino-3-isothiazolidinone-L-serine + + A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine. + + 12802338 + PubMed + + + 12802339 + PubMed + + + AA0344 + RESID + + + Cross-link 2. + + (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid + RESID-systematic + + + 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid + RESID-alternate + + + 4-amino-3-isothiazolidinone-L-serine + RESID-alternate + + + CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser) + UniProt-feature + + + N,N-(L-cysteine-1,S-diyl)-L-serine + RESID-name + + + serine-cysteine sulfenyl amide cross-link + RESID-alternate + + + serine-cysteine sulphenyl amide cross-link + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 3 S 1 + + + + MassAvg + 188.20 + + + + MassMono + 188.025563 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:00916 + MOD:01861 + PSI-MOD + + + MOD:00350 + L-threonyl-pentaglycyl-murein peptidoglycan + + A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide. + + 10754567 + PubMed + + + 1638631 + PubMed + + + AA0345 + RESID + + + + (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine + RESID-alternate + + + L-threonyl-pentaglycyl-murein peptidoglycan + RESID-name + + + MOD_RES Pentaglycyl murein peptidoglycan amidated threonine + UniProt-feature + + + + DiffAvg + 268.25 + + + + DiffFormula + C 10 H 14 N 5 O 4 + + + + DiffMono + 268.104579 + + + + Formula + C 14 H 22 N 6 O 7 + + + + MassAvg + 386.37 + + + + MassMono + 386.154997 + + + + Origin + T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00917 + MOD:01159 + PSI-MOD + + + MOD:00351 + N-glycyl-1-(phosphatidyl)ethanolamine + + A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine. + + 11100732 + PubMed + + + AA0346 + RESID + + + + (R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane + RESID-systematic + + + LIPID Phosphatidylethanolamine amidated glycine + UniProt-feature + + + N-glycyl-1-(phosphatidyl)ethanolamine + RESID-name + + + N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + RESID-alternate + + + + DiffAvg + 699.99 + + + + DiffFormula + C 39 H 74 N 1 O 7 P 1 + + + + DiffMono + 699.520290 + + + + Formula + C 41 H 78 N 2 O 9 P 1 + + + + MassAvg + 774.05 + + + + MassMono + 773.544494 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:00908 + MOD:01155 + PSI-MOD + + + MOD:00352 + L-glutamyl 5-omega-hydroxyceramide ester + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester. + + 10411887 + PubMed + + + 9651377 + PubMed + + + AA0347 + RESID + + + + (S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid + RESID-systematic + + + 2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine + RESID-alternate + + + L-glutamyl 5-omega-hydroxyceramide ester + RESID-name + + + LIPID Omega-hydroxyceramide glutamate ester + UniProt-feature + + + + DiffAvg + 761.31 + + + + DiffFormula + C 50 H 96 N 0 O 4 + + + + DiffMono + 760.730862 + + + + Formula + C 55 H 104 N 2 O 6 + + + + MassAvg + 889.44 + + + + MassMono + 888.789439 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + MOD:01155 + PSI-MOD + + + MOD:00353 + S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium + + A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. + + 12172540 + PubMed + + + 16285713 + PubMed + + + AA0348 + RESID + + + Cross-link 3. + + 5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium + RESID-alternate + + + S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium + RESID-name + + + + DiffAvg + -3.02 + + + + DiffFormula + C 0 H -3 N 0 O 0 S 0 + + + + DiffMono + -3.024024 + + + + FormalCharge + 1+ + + + + Formula + C 25 H 25 N 4 O 4 S 1 + + + + MassAvg + 477.56 + + + + MassMono + 477.159103 + + + + Origin + M, W, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00913 + MOD:00918 + MOD:00919 + PSI-MOD + + + MOD:00354 + O-(riboflavin phosphoryl)-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine. + + 10587447 + PubMed + + + 11163785 + PubMed + + + 11248234 + PubMed + + + AA0349 + RESID + + + 442#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid + RESID-systematic + + + FMN + PSI-MS-label + + + MOD_RES FMN phosphoryl threonine + UniProt-feature + + + O-(riboflavin phosphoryl)-L-threonine + RESID-name + + + O3-(riboflavin phosphoryl) + UniMod-description + + + O3-threonyl flavin mononucleotide + RESID-alternate + + + O3-threonyl FMN + RESID-alternate + + + OFMNThr + PSI-MOD-label + + + + DiffAvg + 438.33 + + + + DiffFormula + C 17 H 19 N 4 O 8 P 1 + + + + DiffMono + 438.094050 + + + + Formula + C 21 H 26 N 5 O 10 P 1 + + + + MassAvg + 539.44 + + + + MassMono + 539.141729 + + + + Origin + T + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00917 + MOD:01164 + PSI-MOD + + + MOD:00355 + O-(riboflavin phosphoryl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine. + + AA0350 + RESID + + + 442#S + UniMod + + + PSI-MOD-slim + + (R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid + RESID-systematic + + + FMN + PSI-MS-label + + + MOD_RES FMN phosphoryl serine + UniProt-feature + + + O-(riboflavin phosphoryl)-L-serine + RESID-name + + + O3-(riboflavin phosphoryl) + UniMod-description + + + O3-seryl flavin mononucleotide + RESID-alternate + + + O3-seryl FMN + RESID-alternate + + + OFMNSer + PSI-MOD-label + + + + DiffAvg + 438.33 + + + + DiffFormula + C 17 H 19 N 4 O 8 P 1 + + + + DiffMono + 438.094050 + + + + Formula + C 20 H 24 N 5 O 10 P 1 + + + + MassAvg + 525.41 + + + + MassMono + 525.126079 + + + + Origin + S + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00916 + MOD:01164 + PSI-MOD + + + MOD:00356 + S-(4a-FMN)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine. + + 12668455 + PubMed + + + 12846567 + PubMed + + + 7692961 + PubMed + + + AA0351 + RESID + + + 443#C + UniMod + + + PSI-MOD-slim + + (R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid + RESID-systematic + + + 4a-(S-cysteinyl)flavin mononucleotide + RESID-alternate + + + 4a-(S-cysteinyl)FMN + RESID-alternate + + + FMNC + PSI-MS-label + + + MOD_RES S-4a-FMN cysteine + UniProt-feature + + + S-(4a-FMN) + UniMod-description + + + S-(4a-FMN)-L-cysteine + RESID-name + + + S4aFMNCys + PSI-MOD-label + + + + DiffAvg + 456.35 + + + + DiffFormula + C 17 H 21 N 4 O 9 P 1 S 0 + + + + DiffMono + 456.104615 + + + + Formula + C 20 H 26 N 5 O 10 P 1 S 1 + + + + MassAvg + 559.49 + + + + MassMono + 559.113800 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00896 + MOD:00905 + PSI-MOD + + + MOD:00357 + 1'-(8alpha-FMN)-L-histidine + + A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine. + + 11902668 + PubMed + + + 8611516 + PubMed + + + AA0352 + RESID + + + 409#H + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid + RESID-systematic + + + 1'-(8alpha-FMN)-L-histidine + RESID-name + + + 8alpha-(N(epsilon)-histidyl)FMN + RESID-alternate + + + 8alpha-(N1'-histidyl)FMN + RESID-alternate + + + flavin mononucleotide + UniMod-description + + + FMNH + PSI-MS-label + + + MOD_RES Tele-8alpha-FMN histidine + UniProt-feature + + + N(tau)-(8alpha-FMN)-histidine + RESID-alternate + + + Ntele8aFMNHis + PSI-MOD-label + + + tele-(8alpha-FMN)-histidine + RESID-alternate + + + + DiffAvg + 454.33 + + + + DiffFormula + C 17 H 19 N 4 O 9 P 1 + + + + DiffMono + 454.088965 + + + + Formula + C 23 H 26 N 7 O 10 P 1 + + + + MassAvg + 591.47 + + + + MassMono + 591.147877 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00896 + MOD:00909 + PSI-MOD + + + MOD:00358 + 3'-(8alpha-FMN)-L-histidine + + A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine. + + 12417325 + PubMed + + + AA0353 + RESID + + + 409#H + UniMod + + + In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + PSI-MOD-slim + + (S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid + RESID-systematic + + + 3'-(8alpha-FMN)-L-histidine + RESID-name + + + 8alpha-(N(delta)-histidyl)FMN + RESID-alternate + + + 8alpha-(N3'-histidyl)FMN + RESID-alternate + + + flavin mononucleotide + UniMod-description + + + FMNH + PSI-MS-label + + + N(pi)-(8alpha-FMN)-histidine + RESID-alternate + + + Npros8aFMNHis + PSI-MOD-label + + + pros-(8alpha-FMN)-histidine + RESID-alternate + + + + DiffAvg + 454.33 + + + + DiffFormula + C 17 H 19 N 4 O 9 P 1 + + + + DiffMono + 454.088965 + + + + Formula + C 23 H 26 N 7 O 10 P 1 + + + + MassAvg + 591.47 + + + + MassMono + 591.147877 + + + + Origin + H + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00896 + MOD:00909 + PSI-MOD + + + MOD:00359 + N2-acetyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine. + + 12883043 + PubMed + + + 1894641 + PubMed + + + AA0354 + RESID + + + + (S)-2-acetamido-5-carbamimidamidopentanoic acid + RESID-systematic + + + 2-acetamido-5-guanidinopentanoic acid + RESID-alternate + + + 2-acetylamino-5-guanidinopentanoic acid + RESID-alternate + + + AcArg + PSI-MOD-label + + + acetylarginine + RESID-alternate + + + alpha-acetylamino-delta-guanidinovaleric acid + RESID-alternate + + + MOD_RES N2-acetylarginine + UniProt-feature + + + N(alpha)-acetylarginine + RESID-alternate + + + N2-acetyl-L-arginine + RESID-name + + + N2-acetylated L-arginine + PSI-MOD-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 15 N 4 O 2 + + + + MassAvg + 199.23 + + + + MassMono + 199.119501 + + + + Origin + R + + + + Source + natural + + + + TermSpec + N-term + + MOD:00902 + MOD:01458 + PSI-MOD + + + MOD:00360 + L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide + + A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide. + + 12475995 + PubMed + + + AA0355 + RESID + + + 444#C + UniMod + + + + [8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide + RESID-systematic + + + copper sulfido molybdopterin cytosine dinuncleotide + UniMod-description + + + CuSMo + PSI-MS-label + + + cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide + RESID-alternate + + + L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide + RESID-name + + + + DiffAvg + 922.07 + + + + DiffFormula + C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3 + + + + DiffMono + 922.834854 + + + + Formula + C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4 + + + + MassAvg + 1025.20 + + + + MassMono + 1025.844039 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00742 + MOD:00744 + MOD:00860 + MOD:00905 + PSI-MOD + + + MOD:00361 + tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. + + 11222759 + PubMed + + + 14704425 + PubMed + + + AA0356 + RESID + + + Cross-link 3. + + METAL Iron-sulfur (4Fe-4S-S-AdoMet) + UniProt-feature + + + tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron) + RESID-systematic + + + tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide + RESID-name + + + + DiffAvg + 747.03 + + + + DiffFormula + C 15 Fe 4 H 19 N 6 O 5 S 5 + + + + DiffMono + 746.742346 + + + + FormalCharge + 1- + + + + Formula + C 24 Fe 4 H 34 N 9 O 8 S 8 + + + + MassAvg + 1056.45 + + + + MassMono + 1055.769901 + + + + Origin + C, C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:00362 + tris-L-cysteinyl L-arginyl diiron disulfide + + A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide. + + 14704425 + PubMed + + + AA0357 + RESID + + + Cross-link 4. + + di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron) + RESID-systematic + + + METAL Iron-sulfur (2Fe-2S) + UniProt-feature + + + tris-L-cysteinyl L-arginyl diiron disulfide + RESID-name + + + + DiffAvg + 172.79 + + + + DiffFormula + C 0 Fe 2 H -3 N 0 O 0 S 2 + + + + DiffMono + 172.791639 + + + + FormalCharge + 2- + + + + Formula + C 15 Fe 2 H 24 N 7 O 4 S 5 + + + + MassAvg + 638.39 + + + + MassMono + 637.920304 + + + + Origin + C, C, C, R + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00902 + MOD:00905 + PSI-MOD + + + MOD:00363 + L-cysteinyl-L-selenocysteine (Cys-Sec) + + A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine. + + 12911312 + PubMed + + + AA0358#SEC + RESID + + + Cross-link 2. + PSI-MOD-slim + + (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid + RESID-systematic + + + CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) + UniProt-feature + + + CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) + UniProt-feature + + + L-cysteinyl-L-selenocysteine + RESID-name + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 Se 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 2 S 1 Se 1 + + + + MassAvg + 251.17 + + + + MassMono + 251.947170 + + + + Origin + C, U + + + + Source + natural + + + + TermSpec + none + + MOD:01158 + MOD:01627 + PSI-MOD + + + MOD:00364 + 5-hydroxy-N6,N6,N6-trimethyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine. + + 11349130 + PubMed + + + 14661085 + PubMed + + + AA0359 + RESID + + + 445#K + UniMod + + + Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074. + + (2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium + RESID-systematic + + + (2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium + RESID-alternate + + + (2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium + RESID-alternate + + + 5-hydroxy-N(zeta)-trimethyllysine + RESID-alternate + + + 5-hydroxy-N6,N6,N6-trimethyl + UniMod-description + + + 5-hydroxy-N6,N6,N6-trimethyl-L-lysine + RESID-name + + + 5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium + RESID-alternate + + + 5-hydroxy-N6,N6,N6-trimethyllysine cation + RESID-alternate + + + 5-hydroxylated N6,N6,N6-trimethylated L-lysine + PSI-MOD-alternate + + + 5HyN6Me3Lys + PSI-MOD-label + + + alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid + RESID-alternate + + + delta-hydroxy-epsilon-N,N,N-trimethyllysine + RESID-alternate + + + Hydroxytrimethyl + PSI-MS-label + + + lysine derivative Lys(z) + RESID-alternate + + + MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine + UniProt-feature + + + + DiffAvg + 59.09 + + + + DiffFormula + C 3 H 7 N 0 O 1 + + + + DiffMono + 59.049141 + + + + FormalCharge + 1+ + + + + Formula + C 9 H 19 N 2 O 2 + + + + MassAvg + 187.26 + + + + MassMono + 187.144104 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00602 + MOD:00912 + + has_functional_parent + MOD:000370 + + + has_functional_parent + MOD:000830 + + PSI-MOD + + + MOD:00365 + N-(L-isoglutamyl)-glycine + + A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine. + + 14531691 + PubMed + + + AA0360 + RESID + + + Cross-link 2. + + (S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid + RESID-systematic + + + 2-amino-N5-(carboxymethyl)-pentanediamic acid + RESID-alternate + + + CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu) + UniProt-feature + + + isoglutamyl glycine + RESID-alternate + + + N-(L-isoglutamyl)-glycine + RESID-name + + + N-gamma-glutamylglycine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 9 N 2 O 3 + + + + MassAvg + 169.16 + + + + MassMono + 169.061317 + + + + Origin + E, G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00688 + MOD:00906 + MOD:00908 + MOD:00954 + PSI-MOD + + + MOD:00366 + O-sulfo-L-serine + + A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine. + + 14752058 + PubMed + + + AA0361 + RESID + + + 40#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(sulfooxy)propanoic acid + RESID-systematic + + + 2-amino-3-hydroxypropanoic acid 3-sulfate + RESID-alternate + + + MOD_RES Sulfoserine + UniProt-feature + + + O-sulfo-L-serine + RESID-name + + + O-Sulfonation + UniMod-description + + + O3-sulfonoserine + RESID-alternate + + + O3-sulfoserine + RESID-alternate + + + serine sulfate ester + RESID-alternate + + + Sulfo + PSI-MS-label + + + + DiffAvg + 80.06 + + + + DiffFormula + C 0 H 0 N 0 O 3 S 1 + + + + DiffMono + 79.956815 + + + + Formula + C 3 H 5 N 1 O 5 S 1 + + + + MassAvg + 167.13 + + + + MassMono + 166.988843 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00695 + MOD:00771 + MOD:00916 + PSI-MOD + + + MOD:00367 + O-sulfo-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine. + + 14752058 + PubMed + + + AA0362 + RESID + + + 40#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(sulfooxy)butanoic acid + RESID-systematic + + + 2-amino-3-hydroxybutanoic acid 3-sulfate + RESID-alternate + + + MOD_RES Sulfothreonine + UniProt-feature + + + O-sulfo-L-threonine + RESID-name + + + O-Sulfonation + UniMod-description + + + O3-sulfonothreonine + RESID-alternate + + + O3-sulfothreonine + RESID-alternate + + + Sulfo + PSI-MS-label + + + threonine sulfate ester + RESID-alternate + + + + DiffAvg + 80.06 + + + + DiffFormula + C 0 H 0 N 0 O 3 S 1 + + + + DiffMono + 79.956815 + + + + Formula + C 4 H 7 N 1 O 5 S 1 + + + + MassAvg + 181.16 + + + + MassMono + 181.004493 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00695 + MOD:00773 + MOD:00917 + PSI-MOD + + + MOD:00368 + N-carboxy-L-methionine + + A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine. + + 10368287 + PubMed + + + 11120890 + PubMed + + + 12595263 + PubMed + + + 8312270 + PubMed + + + AA0363 + RESID + + + 299#M + UniMod + + + At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG]. + + (S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-carbamic-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + 2-carbamic-4-(methylthio)butanoic acid + RESID-alternate + + + Carboxy + UniMod-interim + + + Carboxylation + UniMod-description + + + N-carboxy-L-methionine + RESID-name + + + N-carboxymethionine + RESID-alternate + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 S 0 + + + + DiffMono + 43.989829 + + + + Formula + C 6 H 10 N 1 O 3 S 1 + + + + MassAvg + 176.21 + + + + MassMono + 176.038139 + + + + Origin + M + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00913 + MOD:01152 + PSI-MOD + + + MOD:00369 + O-acetyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine. + + 17981 + ChEBI + + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + 16731519 + PubMed + + + 489587 + PubMed + + + 7309355 + PubMed + + + AA0364 + RESID + + + 1#S + UniMod + + + incidental to RESID:AA0051 + PSI-MOD-slim + + (2S)-3-(acetyloxy)-2-aminopropanoic acid + RESID-systematic + + + Acetyl + PSI-MS-label + + + Acetylation + UniMod-description + + + MOD_RES O-acetylserine + UniProt-feature + + + O-acetyl-L-serine + RESID-name + + + O-acetylated L-serine + PSI-MOD-alternate + + + O-acetylserine + RESID-alternate + + + OAcSer + PSI-MOD-label + + + serine acetate ester + RESID-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00644 + MOD:00647 + PSI-MOD + + + MOD:00370 + (E)-2,3-didehydrotyrosine + + A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine. + + 12623015 + PubMed + + + AA0365 + RESID + + + incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 + PSI-MOD-slim + + (2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid + RESID-systematic + + + (E)-2,3-didehydrogenated tyrosine + PSI-MOD-alternate + + + (E)-2,3-didehydrotyrosine + RESID-name + + + 2-amino-3-oxo-butanoic_acid + UniMod-description + + + amino-(para-hydroxybenzylidenyl)acetic acid + RESID-alternate + + + blue non-fluorescent pocilloporin chromophore + RESID-alternate + + + Didehydro + PSI-MS-label + + + E-dHTyr + PSI-MOD-label + + + MOD_RES (E)-2,3-didehydrotyrosine + UniProt-feature + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + trans-dehydrotyrosine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 9 H 7 N 1 O 2 + + + + MassAvg + 161.16 + + + + MassMono + 161.047678 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00706 + PSI-MOD + + + MOD:00371 + bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide + + A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide. + + 14764885 + PubMed + + + AA0366 + RESID + + + Cross-link 6. + + 4Mn-Ca-4O cluster + RESID-alternate + + + bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide + RESID-name + + + mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese + RESID-systematic + + + photosystem II catalytic cluster + RESID-alternate + + + + DiffAvg + 317.78 + + + + DiffFormula + C 0 Ca 1 H -6 Mn 4 N 0 O 4 + + + + DiffMono + 317.647480 + + + + Formula + C 29 Ca 1 H 32 Mn 4 N 8 O 20 + + + + MassAvg + 1072.44 + + + + MassMono + 1071.888057 + + + + Origin + D, D, E, E, E, H + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00740 + MOD:00904 + MOD:00906 + MOD:00909 + MOD:01482 + PSI-MOD + + + MOD:00372 + 3'-(3'-L-tyrosinyl)-L-tyrosine + + A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine. + + 0 + DeltaMass + + + 14249161 + PubMed + + + 637884 + PubMed + + + 8702710 + PubMed + + + 8937563 + PubMed + + + AA0367 + RESID + + + Cross-link 2; From DeltaMass: Average Mass: -2. + + (2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid) + RESID-systematic + + + 3'-(L-tyros-3'-yl)-L-tyrosine + RESID-name + + + 3,3'-BiTyr (Crosslink) + DeltaMass-label + + + 6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid) + RESID-alternate + + + alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid + RESID-alternate + + + bityrosine + RESID-alternate + + + o,o-dityrosine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 18 H 16 N 2 O 4 + + + + MassAvg + 324.34 + + + + MassMono + 324.111007 + + + + Origin + Y, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00919 + PSI-MOD + + + MOD:00373 + 3'-(O4'-L-tyrosinyl)-L-tyrosine + + A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine. + + 0 + DeltaMass + + + 12719529 + PubMed + + + 7115340 + PubMed + + + 8702710 + PubMed + + + AA0368 + RESID + + + Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2. + + (2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid + RESID-systematic + + + 2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid + RESID-alternate + + + 3'-(L-tyros-O4'-yl)-L-tyrosine + RESID-name + + + CROSSLNK Isodityrosine (Tyr-Tyr) + UniProt-feature + + + IsodiTyr (Crosslink) + DeltaMass-label + + + isodityrosine + RESID-alternate + + + O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 18 H 16 N 2 O 4 + + + + MassAvg + 324.34 + + + + MassMono + 324.111007 + + + + Origin + Y, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00919 + PSI-MOD + + + MOD:00374 + 3,4-dihydroxy-L-arginine + + A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine. + + 10978343 + PubMed + + + 12686488 + PubMed + + + AA0369 + RESID + + + 425#R + UniMod + + + + (2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid + RESID-systematic + + + 2-amino-5-guanidino-3,4-dihydroxypentanoic acid + RESID-alternate + + + 3,4-dihydroxy-L-arginine + RESID-name + + + 3,4-dihydroxylated L-arginine + PSI-MOD-alternate + + + 34Hy2Arg + PSI-MOD-label + + + beta,gamma-dihydroxyarginine + RESID-alternate + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + MOD_RES 3,4-dihydroxyarginine + UniProt-feature + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 12 N 4 O 3 + + + + MassAvg + 188.19 + + + + MassMono + 188.090940 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00428 + MOD:00682 + PSI-MOD + + + MOD:00375 + 4,5-dihydroxy-L-lysine + + A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine. + + 10978343 + PubMed + + + 12686488 + PubMed + + + AA0370 + RESID + + + 425#K + UniMod + + + + (2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid + RESID-systematic + + + 4,5-dihydroxy-L-lysine + RESID-name + + + 4,5-dihydroxylated L-lysine + PSI-MOD-alternate + + + 45Hy2Lys + PSI-MOD-label + + + alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid + RESID-alternate + + + delta,gamma-dihydroxylysine + RESID-alternate + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + MOD_RES 4,5-dihydroxylysine + UniProt-feature + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 12 N 2 O 3 + + + + MassAvg + 160.17 + + + + MassMono + 160.084792 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00428 + MOD:00681 + PSI-MOD + + + MOD:00376 + 1'-(phospho-5'-adenosine)-L-histidine + + A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine. + + 15182206 + PubMed + + + 9323207 + PubMed + + + AA0371 + RESID + + + 405#H + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid + RESID-systematic + + + 1'-(phospho-5'-adenosine)-L-histidine + RESID-name + + + ACT_SITE Tele-AMP-histidine intermediate + UniProt-feature + + + AMP binding site + UniMod-description + + + L-histidine 5'-adenosine phosphoramidester + RESID-alternate + + + L-histidine monoanhydride with 5'-adenylic acid + RESID-alternate + + + N(tau)-5'-adenylic-L-histidine + RESID-alternate + + + N1'-adenylylated histidine + RESID-alternate + + + Phosphoadenosine + PSI-MS-label + + + tele-5'-adenylic-L-histidine + RESID-alternate + + + + DiffAvg + 329.21 + + + + DiffFormula + C 10 H 12 N 5 O 6 P 1 + + + + DiffMono + 329.052520 + + + + Formula + C 16 H 19 N 8 O 7 P 1 + + + + MassAvg + 466.35 + + + + MassMono + 466.111432 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + MOD:01165 + PSI-MOD + + + MOD:00377 + 1'-(phospho-5'-uridine)-L-histidine + + A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine. + + 11467524 + PubMed + + + 321007 + PubMed + + + 380639 + PubMed + + + 8794735 + PubMed + + + AA0372 + RESID + + + 417#H + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid + RESID-systematic + + + 1'-(phospho-5'-uridine)-L-histidine + RESID-name + + + ACT_SITE Tele-UMP-histidine intermediate + UniProt-feature + + + L-histidine 5'-uridine phosphoramidester + RESID-alternate + + + L-histidine monoanhydride with 5'-uridylic acid + RESID-alternate + + + N(tau)-5'-uridylic-L-histidine + RESID-alternate + + + N1'-uridylylated histidine + RESID-alternate + + + PhosphoUridine + PSI-MS-label + + + tele-5'-uridylic-L-histidine + RESID-alternate + + + uridine phosphodiester + UniMod-description + + + + DiffAvg + 306.17 + + + + DiffFormula + C 9 H 11 N 2 O 8 P 1 + + + + DiffMono + 306.025302 + + + + Formula + C 15 H 18 N 5 O 9 P 1 + + + + MassAvg + 443.31 + + + + MassMono + 443.084214 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + MOD:01166 + PSI-MOD + + + MOD:00378 + L-aspartyl semialdehyde + + A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde. + + 1093385 + PubMed + + + 14235557 + PubMed + + + 15237995 + PubMed + + + AA0373 + RESID + + + 447#D + UniMod + + + PSI-MOD-slim + + (S)-2-amino-4-oxobutanoic acid + RESID-systematic + + + aspartyl 4-semialdehyde + PSI-MOD-alternate + + + aspartyl aldehyde + PSI-MOD-alternate + + + Deoxy + PSI-MS-label + + + L-aminosuccinaldehydic acid + RESID-alternate + + + L-aminosuccinic acid semialdehyde + RESID-alternate + + + L-aspartate-beta-semialdehyde + RESID-alternate + + + L-aspartic beta-semialdehyde + RESID-alternate + + + L-aspartyl aldehyde + RESID-name + + + L-beta-formylalanine + RESID-alternate + + + MOD_RES Aspartyl aldehyde + UniProt-feature + + + reduction + UniMod-description + + + + DiffAvg + -16.00 + + + + DiffFormula + C 0 H 0 N 0 O -1 + + + + DiffMono + -15.994915 + + + + Formula + C 4 H 5 N 1 O 2 + + + + MassAvg + 99.09 + + + + MassMono + 99.032028 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01161 + PSI-MOD + + + MOD:00379 + L-serine microcin E492 siderophore ester + + A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester. + + 15102848 + PubMed + + + AA0374 + RESID + + + 448#C-term + UniMod + + + UniMod origin corrected [JSG]. + + L-serine microcin E492 siderophore ester + RESID-name + + + Microcin + PSI-MS-label + + + microcin E492 siderophore ester from serine + UniMod-description + + + MOD_RES Serine microcin E492 siderophore ester + UniProt-feature + + + N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine + RESID-systematic + + + + DiffAvg + 831.69 + + + + DiffFormula + C 36 H 37 N 3 O 20 + + + + DiffMono + 831.197041 + + + + Formula + C 39 H 43 N 4 O 23 + + + + MassAvg + 935.78 + + + + MassMono + 935.231809 + + + + Origin + S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00916 + PSI-MOD + + + MOD:00380 + L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) + + A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). + + 12910261 + PubMed + + + 14725769 + PubMed + + + AA0375 + RESID + + + 424#D + UniMod + + + + 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide + RESID-alternate + + + bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum + RESID-systematic + + + L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) + RESID-name + + + molybdenum bis(molybdopterin guanine dinucleotide) + UniMod-description + + + MolybdopterinGD + PSI-MS-label + + + nitrate reductase A aspartyl Mo-bisMGD cofactor + RESID-alternate + + + phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester + RESID-alternate + + + + DiffAvg + 1572.02 + + + + DiffFormula + C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 + + + + DiffMono + 1572.985775 + + + + Formula + C 44 H 52 Mo 1 N 21 O 29 P 4 S 4 + + + + MassAvg + 1687.10 + + + + MassMono + 1688.012718 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01167 + PSI-MOD + + + MOD:00381 + L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec) + + A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). + + 11372198 + PubMed + + + 12220497 + PubMed + + + AA0376#SEC + RESID + + + + + DiffAvg + 1691.97 + + + + DiffFormula + C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1 + + + + DiffMono + 1691.003369 + + + + Formula + C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1 + + + + MassAvg + 1842.02 + + + + MassMono + 1841.957004 + + + + Origin + U + + + + Source + natural + + + + TermSpec + none + + MOD:00746 + MOD:00748 + MOD:01158 + PSI-MOD + + + MOD:00382 + 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one + + A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one. + + 10852900 + PubMed + + + 11259412 + PubMed + + + 15491166 + PubMed + + + AA0377 + RESID + + + carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + 3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one + RESID-systematic + + + 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol + RESID-alternate + + + 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one + RESID-name + + + GFP-like chromoprotein asFP595 chromophore + RESID-alternate + + + L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine + RESID-alternate + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 14 H 15 N 2 O 2 S 1 + + + + MassAvg + 275.35 + + + + MassMono + 275.085424 + + + + Origin + M, Y + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00913 + MOD:00919 + PSI-MOD + + + MOD:00383 + 2-imino-glutamic acid 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine. + + 11682051 + PubMed + + + AA0378 + RESID + + + Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. + + 2,N-didehydroglutamyl-5-imidazolinone glycine + RESID-alternate + + + 2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 2-imino-glutamic acid 5-imidazolinone glycine + RESID-name + + + 2-imino-glutamyl-5-imidazolinone glycine + RESID-alternate + + + 4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid + RESID-systematic + + + [2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid + RESID-alternate + + + CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly) + UniProt-feature + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 6 N 2 O 3 + + + + MassAvg + 166.14 + + + + MassMono + 166.037842 + + + + Origin + E, G + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00906 + MOD:00908 + MOD:01882 + PSI-MOD + + + MOD:00384 + 2-imino-methionine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine. + + 10852900 + PubMed + + + 12185250 + PubMed + + + 12909624 + PubMed + + + 15542608 + PubMed + + + AA0379 + RESID + + + Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. + + (2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid + RESID-alternate + + + (2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2,N-didehydromethionyl-5-imidazolinone glycine + RESID-alternate + + + 2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 2-imino-methionine 5-imidazolinone glycine + RESID-name + + + 2-imino-methionyl-5-imidazolinone glycine + RESID-alternate + + + CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly) + UniProt-feature + + + GFP-like chromoprotein asFP595 chromophore + RESID-alternate + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + red fluorescent protein eqFP611 chromophore + RESID-alternate + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 8 N 2 O 1 S 1 + + + + MassAvg + 168.21 + + + + MassMono + 168.035734 + + + + Origin + G, M + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:00913 + MOD:01882 + PSI-MOD + + + MOD:00385 + L-asparagine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine. + + 10504696 + PubMed + + + AA0380 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. + + (2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + [2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid + RESID-alternate + + + asparaginyl-5-imidazolinone glycine + RESID-alternate + + + CROSSLNK 5-imidazolinone (Asn-Gly) + UniProt-feature + + + L-asparagine 5-imidazolinone glycine + RESID-name + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + Zoanthus sp. fluorescent protein FP506 chromophore + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 7 N 3 O 2 + + + + MassAvg + 153.14 + + + + MassMono + 153.053826 + + + + Origin + G, N + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00903 + MOD:00908 + MOD:01882 + PSI-MOD + + + MOD:00386 + L-lysine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine. + + 10504696 + PubMed + + + AA0381 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. + + (2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + [2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid + RESID-alternate + + + Anemonia majano fluorescent protein FP486 chromophore + RESID-alternate + + + CROSSLNK 5-imidazolinone (Lys-Gly) + UniProt-feature + + + L-lysine 5-imidazolinone glycine + RESID-name + + + lysyl-5-imidazolinone glycine + RESID-alternate + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 8 H 13 N 3 O 1 + + + + MassAvg + 167.21 + + + + MassMono + 167.105862 + + + + Origin + G, K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00908 + MOD:00912 + MOD:01882 + PSI-MOD + + + MOD:00387 + 2-tetrahydropyridinyl-5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine. + + 10504696 + PubMed + + + 15628861 + PubMed + + + AA0382 + RESID + + + Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. + + 2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine + RESID-alternate + + + 2-tetrahydropyridinyl-5-imidazolinone glycine + RESID-name + + + [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid + RESID-alternate + + + [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid + RESID-systematic + + + CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly) + UniProt-feature + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + Zoanthus sp. fluorescent protein zFP538 chromophore + RESID-alternate + + + + DiffAvg + -37.06 + + + + DiffFormula + C 0 H -7 N -1 O -1 + + + + DiffMono + -37.052764 + + + + Formula + C 8 H 9 N 2 O 1 + + + + MassAvg + 149.17 + + + + MassMono + 149.071488 + + + + Origin + G, K + + + + Source + natural + + + + TermSpec + N-term + + MOD:00908 + MOD:00912 + MOD:01882 + PSI-MOD + + + MOD:00388 + L-alanyl-pentaglycyl-murein peptidoglycan + + A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide. + + 8163519 + PubMed + + + AA0383 + RESID + + + + (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine + RESID-alternate + + + L-alanyl-pentaglycyl-murein peptidoglycan + RESID-name + + + MOD_RES Pentaglycyl murein peptidoglycan amidated alanine + UniProt-feature + + + + DiffAvg + 268.25 + + + + DiffFormula + C 10 H 14 N 5 O 4 + + + + DiffMono + 268.104579 + + + + Formula + C 13 H 20 N 6 O 6 + + + + MassAvg + 356.34 + + + + MassMono + 356.144432 + + + + Origin + A + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00901 + MOD:01159 + PSI-MOD + + + MOD:00389 + N-formyl-L-proline + + A protein modification that effectively converts an L-proline residue to N-formyl-L-proline. + + 12051774 + PubMed + + + 5464655 + PubMed + + + AA0384 + RESID + + + 122#N-term + UniMod + + + CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG]. + + (2S)-1-formylpyrrolidine-2-carboxylic acid + RESID-systematic + + + 1-formyl-2-pyrrolidinecarboxylic acid + RESID-alternate + + + 1-formylproline + RESID-alternate + + + N-formyl-L-proline + RESID-name + + + N-formylated L-proline + PSI-MOD-alternate + + + NFoPro + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 6 H 8 N 1 O 2 + + + + MassAvg + 126.14 + + + + MassMono + 126.055504 + + + + Origin + P + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00409 + MOD:00915 + MOD:01696 + PSI-MOD + + + MOD:00390 + O-decanoyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine. + + 12630926 + PubMed + + + AA0385 + RESID + + + 449#S + UniMod + + + + (2S)-2-amino-3-(decanoyloxy)propanoic acid + RESID-systematic + + + Decanoyl + PSI-MS-label + + + L-serine decanoate ester + RESID-alternate + + + lipid + UniMod-description + + + LIPID O-decanoyl serine + UniProt-feature + + + O-decanoyl-L-serine + RESID-name + + + O-decanoylated L-serine + PSI-MOD-alternate + + + O3-decanoyl-L-serine + RESID-alternate + + + ODecSer + PSI-MOD-label + + + + DiffAvg + 154.25 + + + + DiffFormula + C 10 H 18 N 0 O 1 + + + + DiffMono + 154.135765 + + + + Formula + C 13 H 23 N 1 O 3 + + + + MassAvg + 241.33 + + + + MassMono + 241.167794 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00668 + MOD:00916 + PSI-MOD + + + MOD:00391 + O-octanoyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine. + + 11546772 + PubMed + + + 12716131 + PubMed + + + AA0386 + RESID + + + 426#T + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(octanoyloxy)butanoic acid + RESID-systematic + + + L-threonine octanoate ester + RESID-alternate + + + LIPID O-octanoyl threonine + UniProt-feature + + + O-octanoyl-L-threonine + RESID-name + + + O-octanoylated L-threonine + PSI-MOD-alternate + + + O3-octanoyl-L-threonine + RESID-alternate + + + Octanoyl + PSI-MS-label + + + octanoyl + UniMod-description + + + OOctThr + PSI-MOD-label + + + + DiffAvg + 126.20 + + + + DiffFormula + C 8 H 14 N 0 O 1 + + + + DiffMono + 126.104465 + + + + Formula + C 12 H 21 N 1 O 3 + + + + MassAvg + 227.30 + + + + MassMono + 227.152144 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00669 + MOD:00917 + PSI-MOD + + + MOD:00392 + O-decanoyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine. + + 11546772 + PubMed + + + AA0387 + RESID + + + 449#T + UniMod + + + + (2S)-2-amino-3-(decanoyloxy)propanoic acid + RESID-systematic + + + Decanoyl + PSI-MS-label + + + L-threonine decanoate ester + RESID-alternate + + + lipid + UniMod-description + + + LIPID O-decanoyl threonine + UniProt-feature + + + O-decanoyl-L-threonine + RESID-name + + + O-decanoylated L-threonine + PSI-MOD-alternate + + + O3-decanoyl-L-threonine + RESID-alternate + + + ODecThr + PSI-MOD-label + + + + DiffAvg + 154.25 + + + + DiffFormula + C 10 H 18 N 0 O 1 + + + + DiffMono + 154.135765 + + + + Formula + C 14 H 25 N 1 O 3 + + + + MassAvg + 255.36 + + + + MassMono + 255.183444 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00668 + MOD:00917 + PSI-MOD + + + MOD:00393 + O-methylated residue + + A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid. + + 18688235 + PubMed + + + PSI-MOD-slim + + OMeRes + PSI-MOD-label + + MOD:00427 + PSI-MOD + + + MOD:00394 + acetylated residue + + A protein modification that effectively replaces a hydrogen atom with an acetyl group. + + 0 + DeltaMass + + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 14730666 + PubMed + + + 15350136 + PubMed + + + 1 + UniMod + + + Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42 + PSI-MOD-slim + + Acetyl + PSI-MS-label + + + Acetylation + UniMod-description + + + Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac) + DeltaMass-label + + + AcRes + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:00395 + thioester crosslinked residues + + A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + MOD:00905 + PSI-MOD + + + MOD:00396 + O-glycosylated residue + + A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + OGlycoRes + PSI-MOD-label + + MOD:00693 + PSI-MOD + + + MOD:00397 + iodoacetamide derivatized residue + + A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group. + + 11327326 + PubMed + + + 11510821 + PubMed + + + 12422359 + PubMed + + + 4 + UniMod + + + PSI-MOD-slim + + Carbamidomethyl + PSI-MS-label + + + Iodoacetamide derivative + UniMod-description + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00398 + carbamoylated residue + + A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group. + + 56 + DeltaMass + + + 10978403 + PubMed + + + 12203680 + PubMed + + + 5 + UniMod + + + This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG]. + PSI-MOD-slim + + Carbamyl + UniMod-interim + + + Carbamylation + DeltaMass-label + + + Carbamylation + UniMod-description + + + + DiffAvg + 43.02 + + + + DiffFormula + C 1 H 1 N 1 O 1 + + + + DiffMono + 43.005814 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00399 + iodoacetic acid derivatized residue + + A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group. + + 64 + DeltaMass + + + 6 + UniMod + + + From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine. + PSI-MOD-slim + + Carboxymethyl + PSI-MS-label + + + Carboxymethyl (on Cysteine) + DeltaMass-label + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00400 + deamidated residue + + A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen. + + 32 + DeltaMass + + + 7 + UniMod + + + From DeltaMass: References:Vish Katta. + PSI-MOD-slim + + Deamidated + PSI-MS-label + + + Deamidation + UniMod-description + + + Deamidation of Asparagine and Glutamine to Aspartate and Glutamate + DeltaMass-label + + + deamidationkq + OMSSA-label + + + dNRes + PSI-MOD-label + + + + DiffAvg + 0.98 + + + + DiffFormula + H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00401 + Gygi ICAT(TM) d0 modified cysteine + + A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent. + + 10504701 + PubMed + + + 8#C + UniMod + + + + Gygi ICAT(TM) d0 + UniMod-description + + + ICAT-G + PSI-MS-label + + + + DiffAvg + 486.63 + + + + DiffFormula + C 22 H 38 N 4 O 6 S 1 + + + + DiffMono + 486.251206 + + + + Formula + C 25 H 43 N 5 O 7 S 2 + + + + MassAvg + 589.77 + + + + MassMono + 589.260391 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01820 + PSI-MOD + + + MOD:00402 + Gygi ICAT(TM) d8 modified cysteine + + A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent. + + 10504701 + PubMed + + + 9#C + UniMod + + + + Gygi ICAT(TM) d8 + UniMod-description + + + ICAT-G:2H(8) + PSI-MS-label + + + + DiffAvg + 494.30 + + + + DiffFormula + C 22 (1)H 30 (2)H 8 N 4 O 6 S 1 + + + + DiffMono + 494.301420 + + + + Formula + C 25 (1)H 35 (2)H 8 N 5 O 7 S 2 + + + + MassAvg + 597.31 + + + + MassMono + 597.310605 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01431 + MOD:01820 + PSI-MOD + + + MOD:00403 + homoserine + + A protein modification that effectively converts an L-methionine residue to homoserine. + + 113 + DeltaMass + + + 10#M + UniMod + + + Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group. + PSI-MOD-slim + + ctermpephsem + OMSSA-label + + + Homoserine + UniMod-description + + + Homoserine formed from Met by CNBr treatment + DeltaMass-label + + + Met->Hse + PSI-MS-label + + + + DiffAvg + -30.09 + + + + DiffFormula + C -1 H -2 O 1 S -1 + + + + DiffMono + -29.992806 + + + + Formula + C 4 H 7 N 1 O 2 + + + + MassAvg + 101.10 + + + + MassMono + 101.047678 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00913 + PSI-MOD + + + MOD:00404 + homoserine lactone + + A protein modification that effectively converts an L-methionine residue to homoserine lactone. + + 90 + DeltaMass + + + 11#M + UniMod + + + Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone. + PSI-MOD-slim + + ctermpephselactm + OMSSA-label + + + Homoserine lactone + UniMod-description + + + Met->Hsl + UniMod-interim + + + + DiffAvg + -48.10 + + + + DiffFormula + C -1 H -4 S -1 + + + + DiffMono + -48.003371 + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00601 + MOD:00913 + PSI-MOD + + + MOD:00405 + Applied Biosystems original ICAT(TM) d8 modified cysteine + + A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent. + + 12#C + UniMod + + + PSI-MOD-slim + + Applied Biosystems original ICAT(TM) d8 + UniMod-description + + + ICAT-D:2H(8) + PSI-MS-label + + + + DiffAvg + 450.28 + + + + DiffFormula + C 20 (1)H 26 (2)H 8 N 4 O 5 S 1 + + + + DiffMono + 450.275205 + + + + Formula + C 23 (1)H 31 (2)H 8 N 5 O 6 S 2 + + + + MassAvg + 553.28 + + + + MassMono + 553.284390 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01431 + MOD:01820 + PSI-MOD + + + MOD:00406 + Applied Biosystems original ICAT(TM) d0 modified cysteine + + A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent. + + 13#C + UniMod + + + PSI-MOD-slim + + Applied Biosystems original ICAT(TM) d0 + UniMod-description + + + ICAT-D + PSI-MS-label + + + + DiffAvg + 442.22 + + + + DiffFormula + C 20 (1)H 34 N 4 O 5 S 1 + + + + DiffMono + 442.224991 + + + + Formula + C 23 (1)H 39 N 5 O 6 S 2 + + + + MassAvg + 545.23 + + + + MassMono + 545.234176 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01820 + PSI-MOD + + + MOD:00407 + residue methyl ester + + A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because UniMod:14 merged with entry 34, remap to MOD:00599. + + 14 merged with entry 34 + UniMod + + + 18688235 + PubMed + + + + ResOMe + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 + + + + DiffMono + 14.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00408 + N-acetylated residue + + A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + N-Acetyl + PSI-MOD-alternate + + + N-Acetylation + PSI-MOD-alternate + + + NAcRes + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00394 + MOD:00670 + PSI-MOD + + + MOD:00409 + N-formylated residue + + A protein modification that effectively replaces a residue amino group with a formamido group. + + PSI-MOD-slim + + Formyl + PSI-MS-label + + + NFoRes + PSI-MOD-label + + + ntermformyl + OMSSA-label + + + ntermpepformyl + OMSSA-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 O 1 + + + + DiffMono + 27.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00493 + MOD:00670 + PSI-MOD + + + MOD:00410 + S-(N-isopropylcarboxamidomethyl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine. + + 11465505 + PubMed + + + 8465942 + PubMed + + + 17#C + UniMod + + + + N-isopropylcarboxamidomethyl + UniMod-description + + + NIPCAM + PSI-MS-label + + + nipcam + OMSSA-label + + + + DiffAvg + 99.13 + + + + DiffFormula + C 5 H 9 N 1 O 1 S 0 + + + + DiffMono + 99.068414 + + + + Formula + C 8 H 14 N 2 O 2 S 1 + + + + MassAvg + 202.27 + + + + MassMono + 202.077599 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00411 + O18 label + + modification from UniMod Isotopic label. OBSOLETE because UniMod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label' + + 18 is now merged with entry 258 remap to MOD:00581 'single 018 label'" [PubMed:18688235 + UniMod + + + A modification from UniMod:18 + + + DiffAvg + 2.00 + + + + DiffFormula + (16)O -1 (18)O 1 + + + + DiffMono + 2.004246 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00412 + oxidation + + modification from UniMod artifact. OBSOLETE because UniMod entry 19 is now merged with UniMod 35 remap to MOD:00425 'monohydroxylated residue'. + + 18688235 + PubMed + + + + + DiffAvg + 16.00 + + + + DiffFormula + O 1 + + + + DiffMono + 15.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00413 + biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine + + A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine. + + 20#C + UniMod + + + + Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine + UniMod-description + + + PEO-Iodoacetyl-LC-Biotin + UniMod-interim + + + + DiffAvg + 414.52 + + + + DiffFormula + C 18 H 30 N 4 O 5 S 1 + + + + DiffMono + 414.193691 + + + + Formula + C 21 H 35 N 5 O 6 S 2 + + + + MassAvg + 517.66 + + + + MassMono + 517.202876 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00414 + monomethylated L-arginine + + A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group. + + 215 + DeltaMass + + + 34#R + UniMod + + + From DeltaMass: formula incorrect, N and O reversed + PSI-MOD-slim + + Me1Arg + PSI-MOD-label + + + Methyl + PSI-MS-label + + + methylr + OMSSA-label + + + N-methyl Arginyl + DeltaMass-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 14 N 4 O 1 + + + + MassAvg + 170.22 + + + + MassMono + 170.116761 + + + + Origin + R + + + + Source + none + + + + TermSpec + none + + MOD:00599 + MOD:00658 + PSI-MOD + + + MOD:00415 + phosphorylation without neutral loss + + modification from UniMod - OBSOLETE because UniMod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'. + + 18688235 + PubMed + + + + + DiffAvg + 79.98 + + + + DiffFormula + H 1 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00416 + phosphorylation of an hydroxyl amino acid with prompt loss of phosphate + + A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment. + + 23 + UniMod + + + O4-phosphotyrosine does not lose phosphate by this mechanism. UniMod does not provide a citation for this particular modification [JSG]. + PSI-MOD-slim + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + + DiffAvg + -18.02 + + + + DiffFormula + H -2 O -1 + + + + DiffMono + -18.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00432 + MOD:00704 + PSI-MOD + + + MOD:00417 + S-carboxamidoethyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine. + + 72 + DeltaMass + + + 1481983 + PubMed + + + 24#C + UniMod + + + From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys) + + Acrylamide adduct + UniMod-description + + + PAM-Cys + DeltaMass-label + + + Propionamide + PSI-MS-label + + + Propionamide or Acrylamide adduct + DeltaMass-label + + + propionamidec + OMSSA-label + + + S-(3-amino-3-oxopropyl)cysteine + PSI-MOD-alternate + + + S-carbamoylethyl-L-cysteine + PSI-MOD-alternate + + + S-propanamide-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + 71.08 + + + + DiffFormula + C 3 H 5 N 1 O 1 S 0 + + + + DiffMono + 71.037114 + + + + Formula + C 6 H 10 N 2 O 2 S 1 + + + + MassAvg + 174.22 + + + + MassMono + 174.046299 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00418 + pyridylacetylated residue + + A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group. + + 9276974 + PubMed + + + 25 + UniMod + + + Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. + + Pyridylacetyl + PSI-MS-label + + + pyridylacetyl + UniMod-description + + + + DiffAvg + 119.12 + + + + DiffFormula + C 7 H 5 N 1 O 1 + + + + DiffMono + 119.037114 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00649 + MOD:00848 + PSI-MOD + + + MOD:00419 + (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid + + A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid. + + 336 + DeltaMass + + + 12643538 + PubMed + + + 26#C + UniMod + + + From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue. + + (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid + DeltaMass-label + + + 5-oxothiomorpholine-3-carboxylic acid + PSI-MOD-alternate + + + Otc + DeltaMass-label + + + Pyro-carbamidomethyl + UniMod-interim + + + S-carbamoylmethylcysteine cyclization (N-terminus) + DeltaMass-label + + + S-carbamoylmethylcysteine cyclization (N-terminus) + UniMod-description + + + + DiffAvg + 40.02 + + + + DiffFormula + C 2 H 0 N 0 O 1 S 0 + + + + DiffMono + 39.994915 + + + + Formula + C 5 H 6 N 1 O 2 S 1 + + + + MassAvg + 144.17 + + + + MassMono + 144.011924 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00601 + MOD:00905 + PSI-MOD + + + MOD:00420 + 2-pyrrolidone-5-carboxylic acid (Glu) + + A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid. + + 16 + DeltaMass + + + 10214721 + PubMed + + + 1836357 + PubMed + + + 3473473 + PubMed + + + 8382902 + PubMed + + + AA0031#GLU + RESID + + + 27#E + UniMod + + + From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG]. + + (2S)-5-oxo-2-pyrrolidinecarboxylic acid + RESID-systematic + + + 2-oxopyrrolidine-5-carboxylic acid + RESID-alternate + + + 2-pyrrolidone-5-carboxylic acid + RESID-name + + + 5-oxoproline + RESID-alternate + + + 5-oxopyrrolidine-2-carboxylic acid + RESID-alternate + + + 5-pyrrolidone-2-carboxylic acid + RESID-alternate + + + Glu->pyro-Glu + PSI-MS-label + + + MOD_RES Pyrrolidone carboxylic acid (Glu) + UniProt-feature + + + ntermpeppyroe + OMSSA-label + + + PCA + RESID-alternate + + + PyrGlu(Glu) + PSI-MOD-label + + + Pyro-glu from E + UniMod-description + + + pyroglutamic acid + RESID-alternate + + + Pyroglutamic Acid formed from Glutamic Acid + DeltaMass-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 6 N 1 O 2 + + + + MassAvg + 112.11 + + + + MassMono + 112.039853 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00906 + MOD:01048 + PSI-MOD + + + MOD:00421 + C-glycosylated residue + + A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + CGlycoRes + PSI-MOD-label + + MOD:00693 + PSI-MOD + + + MOD:00422 + alpha-amino morpholine-2-acetylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group. + + 10446193 + PubMed + + + 29#N-term + UniMod + + + The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. + + N-Succinimidyl-2-morpholine acetate + UniMod-description + + + N-succinimidylmorpholine-2-acetate alpha-amino derivative + PSI-MOD-alternate + + + SMA + PSI-MS-label + + + + DiffAvg + 127.14 + + + + DiffFormula + C 6 H 9 N 1 O 2 + + + + DiffMono + 127.063329 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01696 + MOD:01813 + PSI-MOD + + + MOD:00423 + monosodium salt + + A protein modification that effectively substitutes one sodium atom for one hydrogen atom. + + 0 + DeltaMass + + + 30 + UniMod + + + PSI-MOD-slim + + Cation:Na + PSI-MS-label + + + Na1Res + PSI-MOD-label + + + Sodium + DeltaMass-label + + + Sodium adduct + UniMod-description + + + + DiffAvg + 21.98 + + + + DiffFormula + H -1 Na 1 + + + + DiffMono + 21.981944 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00747 + PSI-MOD + + + MOD:00424 + S-pyridylethyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine. + + 253 + DeltaMass + + + 11760118 + PubMed + + + 626389 + PubMed + + + 8297018 + PubMed + + + 8783016 + PubMed + + + 31#C + UniMod + + + From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex + + PECys + DeltaMass-label + + + Pyridylethyl + PSI-MS-label + + + Pyridylethyl Cystenyl + DeltaMass-label + + + S-pyridinylethyl-L-cysteine + PSI-MOD-alternate + + + S-pyridylethylation + UniMod-description + + + spyridylethylc + OMSSA-label + + + vinylpyridine derivatized cysteine residue + PSI-MOD-alternate + + + + DiffAvg + 105.14 + + + + DiffFormula + C 7 H 7 N 1 + + + + DiffMono + 105.057849 + + + + Formula + C 10 H 12 N 2 O 1 S 1 + + + + MassAvg + 208.28 + + + + MassMono + 208.067034 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00425 + monohydroxylated residue + + A protein modification that effectively replaces one hydrogen atom with a hydroxyl group. + + 35 + UniMod + + + PSI-MOD-slim + + Hy1Res + PSI-MOD-label + + + Oxidation + UniMod-interim + + + Oxidation or Hydroxylation + UniMod-description + + + + DiffAvg + 16.00 + + + + DiffFormula + O 1 + + + + DiffMono + 15.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + C-term + + MOD:00677 + PSI-MOD + + + MOD:00426 + S-glycosylated residue + + A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond. + + 18688235 + PubMed + + + + SGlycoRes + PSI-MOD-label + + MOD:00693 + PSI-MOD + + + MOD:00427 + methylated residue + + A protein modification that effectively replaces a hydrogen atom with a methyl group. + + 36 + DeltaMass + + + From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355 + PSI-MOD-slim + + MeRes + PSI-MOD-label + + + Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine) + DeltaMass-label + + MOD:00001 + PSI-MOD + + + MOD:00428 + dihydroxylated residue + + A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups. + + 12686488 + PubMed + + + 425 + UniMod + + + PSI-MOD-slim + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + Hy2Res + PSI-MOD-label + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00677 + PSI-MOD + + + MOD:00429 + dimethylated residue + + A protein modification that effectively replaces two hydrogen atoms with two methyl groups. + + 0 + DeltaMass + + + 12964758 + PubMed + + + 14570711 + PubMed + + + 36 + UniMod + + + For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG]. + PSI-MOD-slim + + di-Methylation + UniMod-description + + + Dimethyl + PSI-MS-label + + + Me2Res + PSI-MOD-label + + + N,N dimethylation (of Arginine or Lysine) + DeltaMass-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00427 + PSI-MOD + + + MOD:00430 + trimethylated residue + + A protein modification that effectively replaces three hydrogen atoms with three methyl groups. + + 12590383 + PubMed + + + 3145979 + PubMed + + + 4304194 + PubMed + + + 6778808 + PubMed + + + 7093227 + PubMed + + + 8453381 + PubMed + + + 37 + UniMod + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation. + PSI-MOD-slim + + Me3Res + PSI-MOD-label + + + tri-Methylation + UniMod-description + + + Trimethyl + PSI-MS-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 + + + + DiffMono + 42.046950 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00427 + PSI-MOD + + + MOD:00431 + modified residue with a secondary neutral loss + + Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment. + + 18688235 + PubMed + + + PSI-MOD-slim + + NLModRes + PSI-MOD-label + + MOD:01157 + PSI-MOD + + + MOD:00432 + modified residue with neutral loss of phosphate + + Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. + + 18688235 + PubMed + + + PSI-MOD-slim + + dPhosModRes + PSI-MOD-label + + MOD:00431 + PSI-MOD + + + MOD:00433 + glucosylated residue + + A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + GlcRes + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00434 + MOD:00726 + PSI-MOD + + + MOD:00434 + hexosylated residue + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond. + + 203 + DeltaMass + + + 15279557 + PubMed + + + 41 + UniMod + + + From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex. + PSI-MOD-slim + + Hex + PSI-MOD-label + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + Hexoses (Fru, Gal, Glc, Man) + DeltaMass-label + + + O-Glycosyl- + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00435 + O-phospho-L-serine with neutral loss of phosphate + + Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. + + 18688235 + PubMed + + + PSI-MOD-slim + + dPhosOPhosSer + PSI-MOD-label + + + + DiffAvg + -97.99 + + + + DiffFormula + C 0 H -3 N 0 O -4 P -1 + + + + DiffMono + -97.976895 + + + + Formula + C 3 H 3 N 1 O 1 + + + + MassAvg + 69.06 + + + + MassMono + 69.021464 + + + + Origin + MOD:00046 + + + + Source + artifact + + + + TermSpec + none + + MOD:01151 + + derives_from + MOD:000460 + + PSI-MOD + + + MOD:00436 + N-acetylhexosaminylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + HexNAc + PSI-MS-label + + + HexNAc + PSI-MOD-label + + + N-Acetylhexosamine + UniMod-description + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00437 + farnesylated residue + + A protein modification that effectively replaces a hydrogen atom with a farnesyl group. + + 0 + DeltaMass + + + 15609361 + PubMed + + + 44 + UniMod + + + From DeltaMass: Average Mass: 204 + PSI-MOD-slim + + Farnesyl + PSI-MS-label + + + Farnesylation + DeltaMass-label + + + Farnesylation + UniMod-description + + + FarnRes + PSI-MOD-label + + + + DiffAvg + 204.36 + + + + DiffFormula + C 15 H 24 + + + + DiffMono + 204.187801 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00703 + PSI-MOD + + + MOD:00438 + myristoylated residue + + A protein modification that effectively replaces a hydrogen atom with a myristoyl group. + + 0 + DeltaMass + + + 45 + UniMod + + + From DeltaMass: Average Mass: 210 + PSI-MOD-slim + + C14:0 aliphatic acylated residue + PSI-MOD-alternate + + + Myristoyl + PSI-MS-label + + + Myristoylation + DeltaMass-label + + + Myristoylation + UniMod-description + + + MyrRes + PSI-MOD-label + + + + DiffAvg + 210.36 + + + + DiffFormula + C 14 H 26 O 1 + + + + DiffMono + 210.198365 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00649 + MOD:01155 + PSI-MOD + + + MOD:00439 + O-phospho-L-threonine with neutral loss of phosphate + + Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. + + 18688235 + PubMed + + + PSI-MOD-slim + + dPhosOPhosThr + PSI-MOD-label + + + + DiffAvg + -97.99 + + + + DiffFormula + C 0 H -3 N 0 O -4 P -1 + + + + DiffMono + -97.976895 + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + MOD:00047 + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01151 + + derives_from + MOD:000470 + + PSI-MOD + + + MOD:00440 + palmitoylated residue + + A protein modification that effectively replaces a hydrogen atom with a palmitoyl group. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 238 + PSI-MOD-slim + + Palmitoyl + PSI-MS-label + + + Palmitoylation + DeltaMass-label + + + Palmitoylation + UniMod-description + + + PamRes + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 O 1 + + + + DiffMono + 238.229666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00649 + MOD:01155 + PSI-MOD + + + MOD:00441 + geranylgeranylated residue + + A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group. + + 0 + DeltaMass + + + 15609361 + PubMed + + + 48 + UniMod + + + From DeltaMass: Average Mass: 272 + PSI-MOD-slim + + Geranyl-geranyl + UniMod-description + + + GeranylGeranyl + PSI-MS-label + + + Geranylgeranylation + DeltaMass-label + + + GergerRes + PSI-MOD-label + + + + DiffAvg + 272.48 + + + + DiffFormula + C 20 H 32 + + + + DiffMono + 272.250401 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00703 + PSI-MOD + + + MOD:00442 + protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide + + Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment. + + 15835918 + PubMed + + + 18688235 + PubMed + + + + dCDI-NNMe2+Arg + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 1 H 2 N 2 O 0 + + + + DiffMono + 42.021798 + + + + Formula + C 7 H 14 N 2 O 1 + + + + MassAvg + 142.20 + + + + MassMono + 142.110613 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00431 + MOD:00902 + PSI-MOD + + + MOD:00443 + protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine + + Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment. + + 15835918 + PubMed + + + 18688235 + PubMed + + + + dDMA-NoMe2+Arg + PSI-MOD-label + + + + DiffAvg + 59.09 + + + + DiffFormula + C 2 H 7 N 2 + + + + DiffMono + 59.060923 + + + + Formula + C 6 H 10 N 3 O 1 + + + + MassAvg + 140.17 + + + + MassMono + 140.082387 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00431 + MOD:00902 + PSI-MOD + + + MOD:00444 + N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine + + A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. + + 10356335 + PubMed + + + 51 + UniMod + + + + N-acyl diglyceride cysteine + UniMod-description + + + ntermpeptripalmitatec + OMSSA-label + + + Tripalmitate + PSI-MS-label + + + + DiffAvg + 789.32 + + + + DiffFormula + C 51 H 96 O 5 + + + + DiffMono + 788.725776 + + + + Formula + C 54 H 101 N 1 O 6 S 1 + + + + MassAvg + 892.46 + + + + MassMono + 891.734961 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00899 + + has_functional_parent + MOD:011440 + + PSI-MOD + + + MOD:00445 + L-homoarginine + + A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea. + + 11078590 + PubMed + + + 11085420 + PubMed + + + 11821862 + PubMed + + + 52 + UniMod + + + PSI-MOD-slim + + Guanidination + UniMod-description + + + guanidinationk + OMSSA-label + + + Guanidinyl + PSI-MS-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 1 H 2 N 2 + + + + DiffMono + 42.021798 + + + + Formula + C 7 H 14 N 4 O 1 + + + + MassAvg + 170.22 + + + + MassMono + 170.116761 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00912 + PSI-MOD + + + MOD:00446 + 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal. + + 11327326 + PubMed + + + 15133838 + PubMed + + + 53 + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + 4-hydroxynonenal (HNE) + UniMod-description + + + HNE + PSI-MS-label + + + + DiffAvg + 156.22 + + + + DiffFormula + C 9 H 16 O 2 + + + + DiffMono + 156.115030 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01155 + PSI-MOD + + + MOD:00447 + N-glucuronylated residue + + A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation. + + 0 + DeltaMass + + + 7398618 + PubMed + + + 54#N-term + UniMod + + + PSI-MOD-slim + + Glucuronyl + PSI-MS-label + + + N-Glucuronyl (N terminus) + DeltaMass-label + + + N-glucuronylation + UniMod-description + + + + DiffAvg + 176.12 + + + + DiffFormula + C 6 H 8 O 6 + + + + DiffMono + 176.032088 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00764 + PSI-MOD + + + MOD:00448 + N-acetylaminoglucosylated residue + + A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + GlcNAcRes + PSI-MOD-label + + + HexNAc + PSI-MS-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00733 + MOD:01673 + PSI-MOD + + + MOD:00449 + acetate labeling reagent (N-term) (heavy form, +3amu) + + modification from UniMod Isotopic label + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 56 + UniMod + + + + Acetate labeling reagent (N-term & K) (heavy form, +3amu) + UniMod-description + + + Acetyl:2H(3) + PSI-MS-label + + + + DiffAvg + 45.03 + + + + DiffFormula + C 2 (1)H -1 (2)H 3 O 1 + + + + DiffMono + 45.029395 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01431 + PSI-MOD + + + MOD:00450 + acetate labeling reagent light form (K) + + OBSOLETE because this isotopic label from UniMod entry 57 is deprecated + + 11857757 + PubMed + + + + + DiffAvg + 42.01 + + + + DiffFormula + C 2 (1)H 2 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00451 + alpha-amino propanoylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 58#N-term + UniMod + + + + Propionate labeling reagent light form (N-term & K) + UniMod-description + + + Propionyl + PSI-MS-label + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01894 + PSI-MOD + + + MOD:00452 + alpha-amino 3x(13)C-labeled propanoylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 59#N-term + UniMod + + + + Propionate labeling reagent heavy form (+3amu), N-term & K + UniMod-description + + + Propionyl:13C(3) + PSI-MS-label + + + + DiffAvg + 59.04 + + + + DiffFormula + (13)C 3 H 4 O 1 + + + + DiffMono + 59.036279 + + + + Formula + (12)C 6 (13)C 3 H 16 N 2 O 2 + + + + MassAvg + 187.13 + + + + MassMono + 187.131242 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00451 + PSI-MOD + + + MOD:00453 + quaternary amine labeling reagent light form (N-term & K) + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group. + + 11857757 + PubMed + + + 60 + UniMod + + + + GIST-Quat + PSI-MS-label + + + Quaternary amine labeling reagent light form (N-term & K) + UniMod-description + + + + DiffAvg + 127.19 + + + + DiffFormula + C 7 H 13 N 1 O 1 + + + + DiffMono + 127.099714 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00454 + quaternary amine labeling reagent heavy form (+3amu) (N-term & K) + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group. + + 11857757 + PubMed + + + 61 + UniMod + + + + GIST-Quat:2H(3) + PSI-MS-label + + + Quaternary amine labeling reagent heavy (+3amu) form, N-term & K + UniMod-description + + + + DiffAvg + 130.12 + + + + DiffFormula + C 7 (1)H 10 (2)H 3 N 1 O 1 + + + + DiffMono + 130.118544 + + + + Formula + C 13 (1)H 22 (2)H 3 N 3 O 2 + + + + MassAvg + 258.21 + + + + MassMono + 258.213507 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00455 + quaternary amine labeling reagent heavy form (+6amu) (N-term & K) + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group. + + 11857757 + PubMed + + + 62 + UniMod + + + + GIST-Quat:2H(6) + PSI-MS-label + + + Quaternary amine labeling reagent heavy form (+6amu), N-term & K + UniMod-description + + + + DiffAvg + 133.14 + + + + DiffFormula + C 7 H 7 (2)H 6 N 1 O 1 + + + + DiffMono + 133.137375 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00456 + quaternary amine labeling reagent heavy form (+9amu) (N-term & K) + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group. + + 11857757 + PubMed + + + 63 + UniMod + + + + GIST-Quat:2H(9) + PSI-MS-label + + + Quaternary amine labeling reagent heavy form (+9amu), N-term & K + UniMod-description + + + + DiffAvg + 136.16 + + + + DiffFormula + C 7 (1)H 4 (2)H 9 N 1 O 1 + + + + DiffMono + 136.156205 + + + + Formula + C 13 (1)H 16 (2)H 9 N 3 O 2 + + + + MassAvg + 264.25 + + + + MassMono + 264.251168 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00457 + alpha-amino succinylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 64#N-term + UniMod + + + + Succinic anhydride labeling reagent light form (N-term) + UniMod-description + + + Succinyl + PSI-MS-label + + + + DiffAvg + 100.02 + + + + DiffFormula + (12)C 4 (1)H 4 O 3 + + + + DiffMono + 100.016044 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00848 + MOD:01029 + MOD:01696 + PSI-MOD + + + MOD:00458 + 4x(2)H labeled alpha-amino succinylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 65#N-term + UniMod + + + + Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term + UniMod-description + + + Succinyl:2H(4) + PSI-MS-label + + + + DiffAvg + 104.04 + + + + DiffFormula + C 4 (2)H 4 O 3 + + + + DiffMono + 104.041151 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00457 + PSI-MOD + + + MOD:00459 + 4x(13)C labeled alpha-amino succinylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 66#N-term + UniMod + + + + Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K + UniMod-description + + + Succinyl:13C(4) + PSI-MS-label + + + + DiffAvg + 104.03 + + + + DiffFormula + (13)C 4 H 4 O 3 + + + + DiffMono + 104.029463 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00457 + PSI-MOD + + + MOD:00460 + L-cysteic acid (L-cysteine sulfonic acid) + + A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid. + + 17285 + ChEBI + + + 334 + DeltaMass + + + 14678012 + PubMed + + + 18306178 + PubMed + + + 19522542 + PubMed + + + 9252331 + PubMed + + + AA0556 + RESID + + + 345#C + UniMod + + + From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. + PSI-MOD-slim + + (2R)-2-amino-3-sulfopropanoic acid + RESID-systematic + + + 2-amino-2-carboxyethanesulfonic acid + RESID-alternate + + + 2-azanyl-3-sulfopropanoic acid + RESID-alternate + + + 3-sulfoalanine + RESID-alternate + + + Cya + DeltaMass-label + + + CysO3H + PSI-MOD-label + + + cysteic acid + RESID-alternate + + + Cysteic acid, oxidation of cysteine + DeltaMass-label + + + cysteicacidc + OMSSA-label + + + cysteine oxidation to cysteic acid + UniMod-description + + + cysteine sulphonic acid + RESID-alternate + + + L-cysteine sulfonic acid + RESID-name + + + Trioxidation + PSI-MS-label + + + + DiffAvg + 48.00 + + + + DiffFormula + C 0 H 0 N 0 O 3 S 0 + + + + DiffMono + 47.984744 + + + + Formula + C 3 H 5 N 1 O 4 S 1 + + + + MassAvg + 151.14 + + + + MassMono + 150.993929 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00708 + PSI-MOD + + + MOD:00461 + nitrosylation + + A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom. + + 0 + DeltaMass + + + 8839040 + PubMed + + + 9252331 + PubMed + + + 354 + UniMod + + + Note, this is often misrepresented as the introduction of a nitrate (NO3) group [JSG]. + PSI-MOD-slim + + Nitro + PSI-MS-label + + + Nitro (NO2) + DeltaMass-label + + + Oxidation to nitro + UniMod-description + + + + DiffAvg + 45.00 + + + + DiffFormula + H -1 N 1 O 2 + + + + DiffMono + 44.985078 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00462 + L-kynurenine + + A protein modification that effectively converts an L-tryptophan residue to L-kynurenine. + + 357 + DeltaMass + + + 11029593 + PubMed + + + 9252331 + PubMed + + + 351#W + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid + PSI-MOD-alternate + + + kynureninw + OMSSA-label + + + Trp->Kynurenin + PSI-MS-label + + + tryptophan oxidation to kynurenin + UniMod-description + + + + DiffAvg + 3.99 + + + + DiffFormula + C -1 O 1 + + + + DiffMono + 3.994915 + + + + Formula + C 10 H 10 N 2 O 2 + + + + MassAvg + 190.20 + + + + MassMono + 190.074228 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00918 + PSI-MOD + + + MOD:00463 + 3'-hydroxy-L-kynurenine + + A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine. + + 9252331 + PubMed + + + 350#W + UniMod + + + PSI-MOD-slim + + hydroxykynureninw + OMSSA-label + + + Trp->Hydroxykynurenin + PSI-MS-label + + + tryptophan oxidation to hydroxykynurenin + UniMod-description + + + + DiffAvg + 19.99 + + + + DiffFormula + C -1 O 2 + + + + DiffMono + 19.989829 + + + + Formula + C 10 H 10 N 2 O 3 + + + + MassAvg + 206.20 + + + + MassMono + 206.069142 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00679 + MOD:00918 + PSI-MOD + + + MOD:00464 + N'-formyl-L-kynurenine + + A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine. + + 356 + DeltaMass + + + 12124932 + PubMed + + + 12686488 + PubMed + + + 9252331 + PubMed + + + 425#W + UniMod + + + From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg. + PSI-MOD-slim + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + Double oxidation of Trp + DeltaMass-label + + + formylkynureninw + OMSSA-label + + + tryptophan oxidation to formylkynurenin + UniMod-alternate + + + + DiffAvg + 32.00 + + + + DiffFormula + O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 11 H 10 N 2 O 3 + + + + MassAvg + 218.21 + + + + MassMono + 218.069142 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00679 + MOD:00918 + PSI-MOD + + + MOD:00465 + dihydroxyphenylalanine (Phe) + + A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine. + + 1610822 + PubMed + + + 1903612 + PubMed + + + 3734192 + PubMed + + + 9252331 + PubMed + + + AA0146#var + RESID + + + 425#F + UniMod + + + Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG]. + PSI-MOD-slim + + dihydroxy + UniMod-description + + + dihydroxyf + OMSSA-label + + + Dioxidation + PSI-MS-label + + + + DiffAvg + 32.00 + + + + DiffFormula + O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 9 H 9 N 1 O 3 + + + + MassAvg + 179.17 + + + + MassMono + 179.058243 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00428 + MOD:00914 + PSI-MOD + + + MOD:00466 + glycosylsphingolipidinositolated residue + + A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated. + + 12626404 + PubMed + + + 18688235 + PubMed + + + 8404891 + PubMed + + + + GSIRes + PSI-MOD-label + + MOD:00764 + MOD:01155 + PSI-MOD + + + MOD:00467 + iminobiotinyl modified residue + + A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom. + + 9750125 + PubMed + + + 89 + UniMod + + + + Iminobiotin + PSI-MS-label + + + Iminobiotinylation + UniMod-description + + + + DiffAvg + 225.31 + + + + DiffFormula + C 10 H 15 N 3 O 1 S 1 + + + + DiffMono + 225.093583 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00468 + ESP-Tag light d0 + + modification from UniMod Isotopic label + + 90 + UniMod + + + + ESP + PSI-MS-label + + + ESP-Tag light d0 + UniMod-description + + + + DiffAvg + 338.47 + + + + DiffFormula + C 16 H 26 N 4 O 2 S 1 + + + + DiffMono + 338.177647 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00469 + ESP-Tag heavy d10 + + modification from UniMod Isotopic label + + 91 + UniMod + + + + ESP-Tag heavy d10 + UniMod-description + + + ESP:2H(10) + PSI-MS-label + + + + DiffAvg + 348.24 + + + + DiffFormula + C 16 (1)H 16 (2)H 10 N 4 O 2 S 1 + + + + DiffMono + 348.240415 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01431 + PSI-MOD + + + MOD:00470 + NHS-LC-Biotin + + modification from UniMod Chemical derivative + + 92 + UniMod + + + + NHS-LC-Biotin + UniMod-interim + + + NHS-LC-Biotin + UniMod-description + + + + DiffAvg + 339.45 + + + + DiffFormula + C 16 H 25 N 3 O 3 S 1 + + + + DiffMono + 339.161663 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00471 + EDT-maleimide-PEO-biotin + + modification from UniMod Chemical derivative + + 93 + UniMod + + + + EDT-maleimide-PEO-biotin + UniMod-interim + + + EDT-maleimide-PEO-biotin + UniMod-description + + + + DiffAvg + 601.80 + + + + DiffFormula + C 25 H 39 N 5 O 6 S 3 + + + + DiffMono + 601.206247 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00472 + IMID d0 + + modification from UniMod Isotopic label + + 11746907 + PubMed + + + 94 + UniMod + + + + IMID + PSI-MS-label + + + IMID d0 + UniMod-description + + + + DiffAvg + 68.04 + + + + DiffFormula + C 3 (1)H 4 N 2 + + + + DiffMono + 68.037448 + + + + Formula + C 9 H 16 N 4 O 1 + + + + MassAvg + 196.13 + + + + MassMono + 196.132411 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00473 + IMID d4 + + modification from UniMod Isotopic label + + 11746907 + PubMed + + + 95 + UniMod + + + + IMID d4 + UniMod-description + + + IMID:2H(4) + PSI-MS-label + + + + DiffAvg + 72.06 + + + + DiffFormula + C 3 (2)H 4 N 2 + + + + DiffMono + 72.062555 + + + + Formula + C 9 (1)H 12 (2)H 4 N 4 O 1 + + + + MassAvg + 200.16 + + + + MassMono + 200.157518 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00474 + S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine. + + 97#C + UniMod + + + + Acrylamide d3 + UniMod-description + + + Propionamide:2H(3) + PSI-MS-label + + + S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine + PSI-MOD-alternate + + + S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine + PSI-MOD-alternate + + + S-([1,1,2-(2)H3]-propanamide)-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + 74.06 + + + + DiffFormula + C 3 (1)H 2 (2)H 3 N 1 O 1 + + + + DiffMono + 74.055944 + + + + Formula + C 6 (1)H 7 (2)H 3 N 2 O 2 S 1 + + + + MassAvg + 177.07 + + + + MassMono + 177.065129 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00417 + MOD:01426 + PSI-MOD + + + MOD:00475 + tyrosine oxidation to 2-aminotyrosine + + modification from UniMod Chemical derivative + + 8839040 + PubMed + + + 9252331 + PubMed + + + 342#Y + UniMod + + + May be misdescribed. Name (if not misdescribed) should be 2'-aminotyrosine [JSG]. + + Amino + PSI-MS-label + + + Tyrosine oxidation to 2-aminotyrosine + UniMod-description + + + + DiffAvg + 15.02 + + + + DiffFormula + H 1 N 1 + + + + DiffMono + 15.010899 + + + + Formula + C 9 H 10 N 2 O 2 + + + + MassAvg + 178.19 + + + + MassMono + 178.074228 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00476 + galactosylated residue + + A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + GalRes + PSI-MOD-label + + MOD:00434 + MOD:00728 + PSI-MOD + + + MOD:00477 + 2-pyrrolidone + + A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain. + + 2161657 + PubMed + + + 9252331 + PubMed + + + 360#P + UniMod + + + The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the UniMod entry. + + Pro->Pyrrolidinone + PSI-MS-label + + + Proline oxidation to pyrrolidinone + UniMod-description + + + + DiffAvg + -13.02 + + + + DiffFormula + C -1 H -1 N 0 O 0 + + + + DiffMono + -13.007825 + + + + Formula + C 4 H 6 N 1 O 1 + + + + MassAvg + 84.10 + + + + MassMono + 84.044939 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00683 + MOD:00915 + MOD:00960 + PSI-MOD + + + MOD:00478 + glutamyl semialdehyde (Pro) + + A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde. + + 354 + DeltaMass + + + 11120890 + PubMed + + + 2563380 + PubMed + + + 9252331 + PubMed + + + 35#P + UniMod + + + + gamma-glutamyl semialdehyde + PSI-MOD-alternate + + + glutamyl 5-semialdehyde + PSI-MOD-alternate + + + glutamyl aldehyde + PSI-MOD-alternate + + + Oxidation + UniMod-interim + + + Oxidation of proline to gamma-glutamyl semialdehyde + DeltaMass-label + + + Oxidation or Hydroxylation + UniMod-description + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00679 + MOD:00915 + MOD:01440 + PSI-MOD + + + MOD:00479 + glutamyl semialdehyde (Arg) + + A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde. + + 351 + DeltaMass + + + 11120890 + PubMed + + + 1680314 + PubMed + + + 9252331 + PubMed + + + 344#R + UniMod + + + From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. + + Arg->GluSA + PSI-MS-label + + + Arginine oxidation to glutamic semialdehyde + UniMod-description + + + Oxidation of arginine (to glutamic acid) + DeltaMass-label + + + + DiffAvg + -43.07 + + + + DiffFormula + C -1 H -5 N -3 O 1 + + + + DiffMono + -43.053433 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00902 + MOD:01440 + PSI-MOD + + + MOD:00480 + Applied Biosystems cleavable ICAT(TM) light + + modification from UniMod Isotopic label + + 105#C + UniMod + + + PSI-MOD-slim + + Applied Biosystems cleavable ICAT(TM) light + UniMod-description + + + ICAT-C + PSI-MS-label + + + icatlight + OMSSA-label + + + + DiffAvg + 227.26 + + + + DiffFormula + C 10 H 17 N 3 O 3 + + + + DiffMono + 227.126991 + + + + Formula + C 13 H 22 N 4 O 4 S 1 + + + + MassAvg + 330.40 + + + + MassMono + 330.136176 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00481 + Applied Biosystems cleavable ICAT(TM) heavy + + modification from UniMod Isotopic label + + 106#C + UniMod + + + PSI-MOD-slim + + Applied Biosystems cleavable ICAT(TM) heavy + UniMod-description + + + ICAT-C:13C(9) + PSI-MS-label + + + icatheavy + OMSSA-label + + + + DiffAvg + 236.16 + + + + DiffFormula + (12)C 1 (13)C 9 H 17 N 3 O 3 + + + + DiffMono + 236.157185 + + + + Formula + (12)C 4 (13)C 9 H 22 N 4 O 4 S 1 + + + + MassAvg + 339.17 + + + + MassMono + 339.166370 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + PSI-MOD + + + MOD:00482 + N-formyl-L-methionine (Met) + + A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process). + + 11152118 + PubMed + + + 2165784 + PubMed + + + 3042771 + PubMed + + + AA0021#MET + RESID + + + This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG]. + + (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-formamido-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + 2-formylamino-4-(methylthio)butanoic acid + RESID-alternate + + + 2-formylazanyl-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + MOD_RES N-formylmethionine + UniProt-feature + + + N-formyl-L-methionine + RESID-name + + + N-formylated L-methionine + PSI-MOD-alternate + + + NFoMet + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 S 0 + + + + DiffMono + 27.994915 + + + + Formula + C 6 H 10 N 1 O 2 S 1 + + + + MassAvg + 160.21 + + + + MassMono + 160.043225 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00030 + MOD:00913 + PSI-MOD + + + MOD:00483 + N-ethylmaleimide derivatized cysteine + + A protein modification that is produced by reaction with N-ethylmaleimide. + + 11813307 + PubMed + + + 12777388 + PubMed + + + 108#C + UniMod + + + + N-ethylmaleimide on cysteines + UniMod-description + + + nemc + OMSSA-label + + + Nethylmaleimide + PSI-MS-label + + + + DiffAvg + 125.13 + + + + DiffFormula + C 6 H 7 N 1 O 2 + + + + DiffMono + 125.047678 + + + + Formula + C 9 H 12 N 2 O 3 S 1 + + + + MassAvg + 228.27 + + + + MassMono + 228.056863 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00484 + oxidized lysine biotinylated with biotin-LC-hydrazide, reduced + + modification from UniMod Chemical derivative + + 112#K + UniMod + + + + Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced + UniMod-description + + + OxLysBiotinRed + UniMod-interim + + + + DiffAvg + 354.47 + + + + DiffFormula + C 16 H 26 N 4 O 3 S 1 + + + + DiffMono + 354.172562 + + + + Formula + C 22 H 38 N 6 O 4 S 1 + + + + MassAvg + 482.64 + + + + MassMono + 482.267525 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00912 + PSI-MOD + + + MOD:00485 + oxidized lysine biotinylated with biotin-LC-hydrazide + + modification from UniMod Chemical derivative + + 113#K + UniMod + + + + Oxidized lysine biotinylated with biotin-LC-hydrazide + UniMod-description + + + OxLysBiotin + UniMod-interim + + + + DiffAvg + 352.45 + + + + DiffFormula + C 16 H 24 N 4 O 3 S 1 + + + + DiffMono + 352.156912 + + + + Formula + C 22 H 36 N 6 O 4 S 1 + + + + MassAvg + 480.63 + + + + MassMono + 480.251875 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00912 + PSI-MOD + + + MOD:00486 + oxidized proline biotinylated with biotin-LC-hydrazide, reduced + + modification from UniMod Chemical derivative + + 114#C + UniMod + + + + Oxidized proline biotinylated with biotin-LC-hydrazide, reduced + UniMod-description + + + OxProBiotinRed + UniMod-interim + + + + DiffAvg + 371.50 + + + + DiffFormula + C 16 H 29 N 5 O 3 S 1 + + + + DiffMono + 371.199111 + + + + Formula + C 21 H 36 N 6 O 4 S 1 + + + + MassAvg + 468.62 + + + + MassMono + 468.251875 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00915 + PSI-MOD + + + MOD:00487 + oxidized proline biotinylated with biotin-LC-hydrazide + + modification from UniMod Chemical derivative + + 115#C + UniMod + + + + Oxidized Proline biotinylated with biotin-LC-hydrazide + UniMod-description + + + OxProBiotin + UniMod-interim + + + + DiffAvg + 369.48 + + + + DiffFormula + C 16 H 27 N 5 O 3 S 1 + + + + DiffMono + 369.183461 + + + + Formula + C 21 H 34 N 6 O 4 S 1 + + + + MassAvg + 466.60 + + + + MassMono + 466.236225 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00915 + PSI-MOD + + + MOD:00488 + oxidized arginine biotinylated with biotin-LC-hydrazide + + modification from UniMod Chemical derivative + + 116#C + UniMod + + + + OxArgBiotin + UniMod-interim + + + Oxidized arginine biotinylated with biotin-LC-hydrazide + UniMod-description + + + + DiffAvg + 310.41 + + + + DiffFormula + C 15 H 22 N 2 O 3 S 1 + + + + DiffMono + 310.135114 + + + + Formula + C 21 H 34 N 6 O 4 S 1 + + + + MassAvg + 466.60 + + + + MassMono + 466.236225 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00902 + PSI-MOD + + + MOD:00489 + oxidized arginine biotinylated with biotin-LC-hydrazide, reduced + + modification from UniMod Chemical derivative + + 117#C + UniMod + + + + OxArgBiotinRed + UniMod-interim + + + Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced + UniMod-description + + + + DiffAvg + 312.43 + + + + DiffFormula + C 15 H 24 N 2 O 3 S 1 + + + + DiffMono + 312.150764 + + + + Formula + C 21 H 36 N 6 O 4 S 1 + + + + MassAvg + 468.62 + + + + MassMono + 468.251875 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00902 + PSI-MOD + + + MOD:00490 + EDT-iodo-PEO-biotin + + modification from UniMod Chemical derivative + + 118 + UniMod + + + + EDT-iodo-PEO-biotin + UniMod-description + + + EDT-iodoacetyl-PEO-biotin + PSI-MS-label + + + + DiffAvg + 490.70 + + + + DiffFormula + C 20 H 34 N 4 O 4 S 3 + + + + DiffMono + 490.174219 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00491 + thio ether formation - BTP Adduct + + modification from UniMod Chemical derivative + + 11861642 + PubMed + + + 119#C + UniMod + + + + IBTP + PSI-MS-label + + + Thio Ether Formation - BTP Adduct + UniMod-description + + + + DiffAvg + 316.38 + + + + DiffFormula + C 22 H 21 P 1 + + + + DiffMono + 316.138087 + + + + Formula + C 25 H 26 N 1 O 1 P 1 S 1 + + + + MassAvg + 419.52 + + + + MassMono + 419.147272 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00861 + MOD:00905 + PSI-MOD + + + MOD:00492 + ubiquitination signature dipeptidyl lysine + + A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin. + + 11125103 + PubMed + + + 12612601 + PubMed + + + 12872131 + PubMed + + + AA0125#var + RESID + + + 121#K + UniMod + + + + GlyGly + PSI-MS-label + + + glyglyk + OMSSA-label + + + N6-(glycylglycyl)lysine + PSI-MOD-alternate + + + N6-glycylglycyl-L-lysine + PSI-MOD-alternate + + + ubiquitinylation residue + UniMod-description + + + + DiffAvg + 114.10 + + + + DiffFormula + C 4 H 6 N 2 O 2 + + + + DiffMono + 114.042927 + + + + Formula + C 10 H 18 N 4 O 3 + + + + MassAvg + 242.28 + + + + MassMono + 242.137890 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00908 + MOD:01875 + + derives_from + MOD:011480 + + PSI-MOD + + + MOD:00493 + formylated residue + + A protein modification that effectively replaces a hydrogen atom with a formyl group. + + 0 + DeltaMass + + + 15799070 + PubMed + + + 122 + UniMod + + + From DeltaMass: Average Mass: 28 + PSI-MOD-slim + + FoRes + PSI-MOD-label + + + Formyl + PSI-MS-label + + + Formylation + UniMod-description + + + Formylation (CHO) + DeltaMass-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 O 1 + + + + DiffMono + 27.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:00494 + N-iodoacetyl, p-chlorobenzyl-12C6-glucamine + + modification from UniMod Isotopic label + + 12185208 + PubMed + + + 123#C + UniMod + + + + ICAT-H + PSI-MS-label + + + N-iodoacetyl, p-chlorobenzyl-12C6-glucamine + UniMod-description + + + + DiffAvg + 345.78 + + + + DiffFormula + C 15 Cl 1 H 20 N 1 O 6 S 0 + + + + DiffMono + 345.097915 + + + + Formula + C 18 Cl 1 H 25 N 2 O 7 S 1 + + + + MassAvg + 448.91 + + + + MassMono + 448.107100 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + MOD:01426 + PSI-MOD + + + MOD:00495 + N-iodoacetyl, p-chlorobenzyl-13C6-glucamine + + modification from UniMod Isotopic label + + 12185208 + PubMed + + + 124#C + UniMod + + + + ICAT-H:13C(6) + PSI-MS-label + + + N-iodoacetyl, p-chlorobenzyl-13C6-glucamine + UniMod-description + + + + DiffAvg + 351.12 + + + + DiffFormula + (12)C 9 (13)C 6 Cl 1 H 20 N 1 O 6 S 0 + + + + DiffMono + 351.118044 + + + + Formula + (12)C 12 (13)C 6 Cl 1 H 25 N 2 O 7 S 1 + + + + MassAvg + 454.13 + + + + MassMono + 454.127229 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + MOD:01426 + PSI-MOD + + + MOD:00496 + reductive amination-D + + OBSOLETE because UniMod entry 125 is merged with entry 199, remap to id: MOD:00552 + + 125 + UniMod + + + + + DiffAvg + 32.06 + + + + DiffFormula + C 2 (2)H 4 + + + + DiffMono + 32.056407 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00497 + 3-sulfanylpropanoyl (N-term and Lys) + + modification from UniMod [(35)S]dithiobis(succinimidyl propionate) crosslinking + + 957432 + PubMed + + + 126 + UniMod + + + The name "thioacylation of primary amines" in UniMod was a misdescription [JSG]. + + 3,3-Dithio-bis-(sulfosuccinimidyl)propionate + UniMod-alternate + + + 3-sulfanylpropanoyl + UniMod-description + + + Thioacyl + PSI-MS-label + + + + DiffAvg + 88.12 + + + + DiffFormula + C 3 H 4 O 1 S 1 + + + + DiffMono + 87.998286 + + + + Formula + C 9 H 16 N 2 O 2 S 1 + + + + MassAvg + 216.30 + + + + MassMono + 216.093249 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00912 + PSI-MOD + + + MOD:00498 + fluorinated residue + + A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom. + + 18688235 + PubMed + + + + Fluoro + PSI-MS-label + + + fluorophenylalanine replacement of phenylalanine + UniMod-description + + + Fluorophenylalanyl + DeltaMass-label + + + FRes + PSI-MOD-label + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00694 + PSI-MOD + + + MOD:00499 + 5-iodoacetamidofluorescein + + modification from UniMod Chemical derivative + + 3311742 + PubMed + + + 3578767 + PubMed + + + 128#C + UniMod + + + + 5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR) + UniMod-description + + + Fluorescein + PSI-MS-label + + + + DiffAvg + 388.35 + + + + DiffFormula + C 22 H 14 N 1 O 6 + + + + DiffMono + 388.082112 + + + + Formula + C 25 H 19 N 2 O 7 S 1 + + + + MassAvg + 491.49 + + + + MassMono + 491.091297 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00500 + monoiodinated residue + + A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom. + + 0 + DeltaMass + + + 15627961 + PubMed + + + 2026710 + PubMed + + + 129 + UniMod + + + From DeltaMass: Average Mass: 126 + PSI-MOD-slim + + I1Res + PSI-MOD-label + + + Iodination + UniMod-description + + + Iodination (of Histidine[C4] or Tyrosine[C3]) + DeltaMass-label + + + Iodo + PSI-MS-label + + + + DiffAvg + 125.90 + + + + DiffFormula + H -1 I 1 + + + + DiffMono + 125.896648 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00755 + PSI-MOD + + + MOD:00501 + diiodinated residue + + A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms. + + 130 + UniMod + + + From DeltaMass: Average Mass: 252 + PSI-MOD-slim + + di-Iodination + UniMod-description + + + Diiodo + PSI-MS-label + + + I2Res + PSI-MOD-label + + + + DiffAvg + 251.79 + + + + DiffFormula + H -2 I 2 + + + + DiffMono + 251.793295 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + none + + MOD:00755 + PSI-MOD + + + MOD:00502 + triiodinated residue + + A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms. + + 15627961 + PubMed + + + 2026710 + PubMed + + + 131 + UniMod + + + From UniMod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG]. + PSI-MOD-slim + + I3Res + PSI-MOD-label + + + tri-Iodination + UniMod-description + + + triiodinationy + OMSSA-label + + + Triiodo + PSI-MS-label + + + + DiffAvg + 377.69 + + + + DiffFormula + H -3 I 3 + + + + DiffMono + 377.689943 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00755 + PSI-MOD + + + MOD:00503 + N-(cis-delta 5)-tetradecaenoylglycine + + A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine. + + 11955007 + PubMed + + + 11955008 + PubMed + + + 1326520 + PubMed + + + 1386601 + PubMed + + + 6436247 + PubMed + + + 7543369 + PubMed + + + AA0059#var + RESID + + + 134#G + UniMod + + + + (cis-delta 5)-tetradecaenoyl + UniMod-description + + + Myristoleyl + PSI-MS-label + + + myristoleylation (one double bond) + DeltaMass-label + + + N-(C14:1 aliphatic acyl)glycine + PSI-MOD-alternate + + + ntermpepmyristoyeylationg + OMSSA-label + + + + DiffAvg + 208.35 + + + + DiffFormula + C 14 H 24 N 0 O 1 + + + + DiffMono + 208.182715 + + + + Formula + C 16 H 27 N 1 O 2 + + + + MassAvg + 265.40 + + + + MassMono + 265.204179 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00908 + MOD:01696 + PSI-MOD + + + MOD:00504 + N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine + + A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine. + + 11955007 + PubMed + + + 11955008 + PubMed + + + 1326520 + PubMed + + + 1386601 + PubMed + + + 6436247 + PubMed + + + 7543369 + PubMed + + + AA0059#var + RESID + + + 135#G + UniMod + + + + (cis,cis-delta 5, delta 8)-tetradecadienoyl + UniMod-description + + + Myristoyl+Delta:H(-4) + PSI-MS-label + + + myristoylation-4H (two double bonds) + DeltaMass-label + + + N-(C14:2 aliphatic acyl)glycine + PSI-MOD-alternate + + + ntermpepmyristoyl4hg + OMSSA-label + + + + DiffAvg + 206.33 + + + + DiffFormula + C 14 H 22 O 1 + + + + DiffMono + 206.167065 + + + + Formula + C 16 H 25 N 1 O 2 + + + + MassAvg + 263.38 + + + + MassMono + 263.188529 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00908 + MOD:01696 + PSI-MOD + + + MOD:00505 + benzoyl labeling reagent light form (N-term and K) + + modification from UniMod Isotopic label + + 0 + DeltaMass + + + 15456300 + PubMed + + + 136 + UniMod + + + From DeltaMass: Average Mass: 104 + + Benzoyl + PSI-MS-label + + + Benzoyl (Bz) + DeltaMass-label + + + labeling reagent light form (N-term & K) + UniMod-description + + + + DiffAvg + 104.11 + + + + DiffFormula + C 7 H 4 O 1 + + + + DiffMono + 104.026215 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00506 + N-linked glycan core + + modification from UniMod N-linked glycosylation, Hex(5) HexNAc(2) + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 137#N + UniMod + + + + Hex(5)HexNAc(2) + PSI-MS-label + + + N-linked glycan core + UniMod-description + + + + DiffAvg + 1217.09 + + + + DiffFormula + C 46 H 76 N 2 O 35 + + + + DiffMono + 1216.422862 + + + + Formula + C 50 H 82 N 4 O 37 + + + + MassAvg + 1331.20 + + + + MassMono + 1330.465790 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00507 + 5-dimethylaminonaphthalene-1-sulfonyl + + OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653. + + 0 + DeltaMass + + + 139 + UniMod + + + From DeltaMass: Average Mass: 233 + + 5-dimethylaminonaphthalene-1-sulfonyl + UniMod-description + + + Dansyl + PSI-MS-label + + + Dansyl (Dns) + DeltaMass-label + + + + DiffAvg + 233.29 + + + + DiffFormula + C 12 H 11 N 1 O 2 S 1 + + + + DiffMono + 233.051050 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00508 + ISD a-series (C-Term) + + modification from UniMod Other + + 14588022 + PubMed + + + 140 + UniMod + + + Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer. + + a-type-ion + PSI-MS-label + + + ISD a-series (C-Term) + UniMod-description + + + + DiffAvg + -29.02 + + + + DiffFormula + C -1 H -1 O -1 + + + + DiffMono + -29.002740 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00003 + PSI-MOD + + + MOD:00509 + amidination of lysines or N-terminal amines with methyl acetimidate + + modification from UniMod Chemical derivative + + 12643539 + PubMed + + + 6273432 + PubMed + + + 141 + UniMod + + + + amidination of lysines or N-terminal amines with methyl acetimidate + UniMod-description + + + Amidine + PSI-MS-label + + + + DiffAvg + 41.05 + + + + DiffFormula + C 2 H 3 N 1 + + + + DiffMono + 41.026549 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00510 + HexNAc1dHex1 + + modification from UniMod N-linked glycosylation, dHex HexNAc + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 142 + UniMod + + + + dHexHexNAcN + OMSSA-label + + + HexNAc(1)dHex(1) + PSI-MS-label + + + HexNAc1dHex1 + UniMod-description + + + + DiffAvg + 349.34 + + + + DiffFormula + C 14 H 23 N 1 O 9 + + + + DiffMono + 349.137281 + + + + Formula + C 18 H 29 N 3 O 11 + + + + MassAvg + 463.44 + + + + MassMono + 463.180209 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00511 + HexNAc2 + + modification from UniMod N-linked glycosylation, HexNAc(2) + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 143 + UniMod + + + + HexNAc(2) + PSI-MS-label + + + HexNAc2 + UniMod-description + + + + DiffAvg + 406.39 + + + + DiffFormula + C 16 H 26 N 2 O 10 + + + + DiffMono + 406.158745 + + + + Formula + C 20 H 32 N 4 O 12 + + + + MassAvg + 520.49 + + + + MassMono + 520.201672 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00512 + Hex3 + + modification from UniMod N-linked glycosylation, Hex3 + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 144 + UniMod + + + + Hex(3) + PSI-MS-label + + + Hex3 + UniMod-description + + + + DiffAvg + 486.42 + + + + DiffFormula + C 18 H 30 O 15 + + + + DiffMono + 486.158470 + + + + Formula + C 22 H 36 N 2 O 17 + + + + MassAvg + 600.53 + + + + MassMono + 600.201398 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00513 + HexNAc1dHex2 + + modification from UniMod N-linked glycosylation, dHex(2) HexNAc + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 145 + UniMod + + + + HexNAc(1)dHex(2) + PSI-MS-label + + + HexNAc1dHex2 + UniMod-description + + + + DiffAvg + 495.48 + + + + DiffFormula + C 20 H 33 N 1 O 13 + + + + DiffMono + 495.195190 + + + + Formula + C 24 H 39 N 3 O 15 + + + + MassAvg + 609.58 + + + + MassMono + 609.238118 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00514 + Hex1HexNAc1dHex1 + + modification from UniMod N-linked glycosylation, dHex Hex HexNAc + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 146 + UniMod + + + + Hex(1)HexNAc(1)dHex(1) + PSI-MS-label + + + Hex1HexNAc1dHex1 + UniMod-description + + + + DiffAvg + 511.48 + + + + DiffFormula + C 20 H 33 N 1 O 14 + + + + DiffMono + 511.190105 + + + + Formula + C 24 H 39 N 3 O 16 + + + + MassAvg + 625.58 + + + + MassMono + 625.233032 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00515 + HexNAc2dHex1 + + modification from UniMod N-linked glycosylation, dHex HexNAc(2) + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + 147 + UniMod + + + + HexNAc(2)dHex(1) + PSI-MS-label + + + HexNAc2dHex1 + UniMod-description + + + + DiffAvg + 552.53 + + + + DiffFormula + C 22 H 36 N 2 O 14 + + + + DiffMono + 552.216654 + + + + Formula + C 26 H 42 N 4 O 16 + + + + MassAvg + 666.63 + + + + MassMono + 666.259581 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00516 + Hex1HexNAc2 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 148 + UniMod + + + + Hex(1)HexNAc(2) + PSI-MS-label + + + Hex1HexNAc2 + UniMod-description + + + + DiffAvg + 568.53 + + + + DiffFormula + C 22 H 36 N 2 O 15 + + + + DiffMono + 568.211568 + + + + Formula + C 26 H 42 N 4 O 17 + + + + MassAvg + 682.63 + + + + MassMono + 682.254496 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00517 + Hex1HexNAc1NeuAc1 glycosylated residue + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. + + 0 + DeltaMass + + + 149 + UniMod + + + From DeltaMass: Average Mass: 657 + + Hex(1)HexNAc(1)NeuAc(1) + PSI-MS-label + + + Hex1HexNAc1NeuAc1 + UniMod-description + + + NeuAc-Hex-HexNAc + DeltaMass-label + + + + DiffAvg + 657.60 + + + + DiffFormula + C 25 H 41 N 2 O 18 + + + + DiffMono + 657.235437 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00518 + HexNAc2dHex2 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 150 + UniMod + + + + HexNAc(2)dHex(2) + PSI-MS-label + + + HexNAc2dHex2 + UniMod-description + + + + DiffAvg + 698.67 + + + + DiffFormula + C 28 H 46 N 2 O 18 + + + + DiffMono + 698.274563 + + + + Formula + C 32 H 52 N 4 O 20 + + + + MassAvg + 812.78 + + + + MassMono + 812.317490 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00519 + Hex1HexNAc2Pent1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 151 + UniMod + + + + Hex(1)HexNAc(2)Pent(1) + PSI-MS-label + + + Hex1HexNAc2Pent1 + UniMod-description + + + + DiffAvg + 700.64 + + + + DiffFormula + C 27 H 44 N 2 O 19 + + + + DiffMono + 700.253827 + + + + Formula + C 31 H 50 N 4 O 21 + + + + MassAvg + 814.75 + + + + MassMono + 814.296755 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00520 + Hex1HexNAc2dHex1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 152 + UniMod + + + + Hex(1)HexNAc(2)dHex(1) + PSI-MS-label + + + Hex1HexNAc2dHex1 + UniMod-description + + + + DiffAvg + 714.67 + + + + DiffFormula + C 28 H 46 N 2 O 19 + + + + DiffMono + 714.269477 + + + + Formula + C 32 H 52 N 4 O 21 + + + + MassAvg + 828.77 + + + + MassMono + 828.312405 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00521 + Hex2HexNAc2 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 153 + UniMod + + + + Hex(2)HexNAc(2) + PSI-MS-label + + + Hex2HexNAc2 + UniMod-description + + + + DiffAvg + 730.67 + + + + DiffFormula + C 28 H 46 N 2 O 20 + + + + DiffMono + 730.264392 + + + + Formula + C 32 H 52 N 4 O 22 + + + + MassAvg + 844.77 + + + + MassMono + 844.307319 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00522 + Hex3HexNAc1Pent1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 154 + UniMod + + + + Hex(3)HexNAc(1)Pent(1) + PSI-MS-label + + + Hex3HexNAc1Pent1 + UniMod-description + + + + DiffAvg + 821.73 + + + + DiffFormula + C 31 H 51 N 1 O 24 + + + + DiffMono + 821.280102 + + + + Formula + C 35 H 57 N 3 O 26 + + + + MassAvg + 935.84 + + + + MassMono + 935.323029 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00523 + Hex1HexNAc2dHex1Pent1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 155 + UniMod + + + + Hex(1)HexNAc(2)dHex(1)Pent(1) + PSI-MS-label + + + Hex1HexNAc2dHex1Pent1 + UniMod-description + + + + DiffAvg + 846.79 + + + + DiffFormula + C 33 H 54 N 2 O 23 + + + + DiffMono + 846.311736 + + + + Formula + C 35 H 57 N 3 O 26 + + + + MassAvg + 935.84 + + + + MassMono + 935.323029 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00524 + Hex1HexNAc2dHex2 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 156 + UniMod + + + + Hex(1)HexNAc(2)dHex(2) + PSI-MS-label + + + Hex1HexNAc2dHex2 + UniMod-description + + + + DiffAvg + 860.81 + + + + DiffFormula + C 34 H 56 N 2 O 23 + + + + DiffMono + 860.327386 + + + + Formula + C 38 H 62 N 4 O 25 + + + + MassAvg + 974.92 + + + + MassMono + 974.370313 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00525 + Hex2HexNAc2Pent1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 157 + UniMod + + + + Hex(2)HexNAc(2)Pent(1) + PSI-MS-label + + + Hex2HexNAc2Pent1 + UniMod-description + + + + DiffAvg + 862.79 + + + + DiffFormula + C 33 H 54 N 2 O 24 + + + + DiffMono + 862.306651 + + + + Formula + C 37 H 60 N 4 O 26 + + + + MassAvg + 976.89 + + + + MassMono + 976.349578 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00526 + Hex2HexNAc2dHex1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 158 + UniMod + + + + Hex(2)HexNAc(2)dHex(1) + PSI-MS-label + + + Hex2HexNAc2dHex1 + UniMod-description + + + + DiffAvg + 876.81 + + + + DiffFormula + C 34 H 56 N 2 O 24 + + + + DiffMono + 876.322301 + + + + Formula + C 38 H 62 N 4 O 26 + + + + MassAvg + 990.92 + + + + MassMono + 990.365228 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00527 + Hex3HexNAc2 + + modification from UniMod N-linked glycosylation + + 0 + DeltaMass + + + AA0151#var + RESID + + + 159 + UniMod + + + From DeltaMass: Average Mass: 893 + + (Hex)3-HexNAc-HexNAc + DeltaMass-label + + + Hex(3)HexNAc(2) + PSI-MS-label + + + Hex3HexNAc2 + UniMod-description + + + + DiffAvg + 892.81 + + + + DiffFormula + C 34 H 56 N 2 O 25 + + + + DiffMono + 892.317215 + + + + Formula + C 38 H 62 N 4 O 27 + + + + MassAvg + 1006.92 + + + + MassMono + 1006.360143 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00528 + Hex1HexNAc1NeuAc2 glycosylated residue + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. + + 160 + UniMod + + + + Hex(1)HexNAc(1)NeuAc(2) + PSI-MS-label + + + Hex1HexNAc1NeuAc2 + UniMod-description + + + + DiffAvg + 947.85 + + + + DiffFormula + C 36 H 57 N 3 O 26 + + + + DiffMono + 947.323029 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00529 + Hex3HexNAc2P1 + + modification from UniMod N-linked glycosylation + + AA0151#var + RESID + + + 161 + UniMod + + + + Hex(3)HexNAc(2)P(1) + PSI-MS-label + + + Hex3HexNAc2P1 + UniMod-description + + + + DiffAvg + 972.79 + + + + DiffFormula + C 34 H 57 N 2 O 28 P 1 + + + + DiffMono + 972.283546 + + + + Formula + C 38 H 63 N 4 O 30 P 1 + + + + MassAvg + 1086.89 + + + + MassMono + 1086.326473 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00530 + L-selenomethionine + + A protein modification that effectively converts an L-methionine residue to L-selenomethionine. + + 12148805 + PubMed + + + 162#M + UniMod + + + + Delta:S(-1)Se(1) + PSI-MS-label + + + Se(S)Met + PSI-MOD-label + + + Selenium replaces sulphur + UniMod-description + + + semetm + OMSSA-label + + + + DiffAvg + 46.91 + + + + DiffFormula + C 0 H 0 N 0 S -1 Se 1 + + + + DiffMono + 47.944450 + + + + Formula + C 5 H 9 N 1 O 1 Se 1 + + + + MassAvg + 178.10 + + + + MassMono + 178.984935 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00007 + MOD:00913 + PSI-MOD + + + MOD:00531 + (18)O labeled deglycosylated asparagine + + A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water. + + 14435542 + PubMed + + + 170 + UniMod + + + PSI-MOD-slim + + Delta:H(1)O(-1)18O(1) + PSI-MS-label + + + glycosylated asparagine 18O labeling + UniMod-description + + + + DiffAvg + 2.99 + + + + DiffFormula + H -1 N -1 (18)O 1 + + + + DiffMono + 2.988262 + + + + Formula + C 4 H 5 N 1 (16)O 2 (18)O 1 + + + + MassAvg + 117.03 + + + + MassMono + 117.031189 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:01293 + PSI-MOD + + + MOD:00532 + Shimadzu 13CNBS + + modification from UniMod Chemical derivative + + 12845591 + PubMed + + + 171 + UniMod + + + + NBS:13C(6) + UniMod-interim + + + Shimadzu NBS-13C + UniMod-description + + + + DiffAvg + 159.01 + + + + DiffFormula + (13)C 6 H 3 N 1 O 2 S 1 + + + + DiffMono + 159.008578 + + + + Formula + (12)C 11 (13)C 6 H 13 N 3 O 3 S 1 + + + + MassAvg + 345.09 + + + + MassMono + 345.087891 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00533 + Shimadzu 12CNBS + + modification from UniMod Chemical derivative + + 12845591 + PubMed + + + 172 + UniMod + + + + NBS + UniMod-interim + + + Shimadzu NBS-12C + UniMod-description + + + + DiffAvg + 152.99 + + + + DiffFormula + (12)C 6 H 3 N 1 O 2 S 1 + + + + DiffMono + 152.988449 + + + + Formula + (12)C 17 H 13 N 3 O 3 S 1 + + + + MassAvg + 339.07 + + + + MassMono + 339.067762 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00534 + Michael addition of BHT quinone methide to cysteine and lysine + + modification from UniMod Post-translational + + 9448752 + PubMed + + + 176 + UniMod + + + Butylated Hydroxytoluene adduct. + + BHT + PSI-MS-label + + + Michael addition of BHT quinone methide to Cysteine and Lysine + UniMod-description + + + + DiffAvg + 218.34 + + + + DiffFormula + C 15 H 22 O 1 + + + + DiffMono + 218.167065 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00535 + phosphorylation to amine thiol + + modification from UniMod Chemical derivative + + 12216740 + PubMed + + + 178 + UniMod + + + DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site. + + DAET + PSI-MS-label + + + phosphorylation to amine thiol + UniMod-description + + + + DiffAvg + 87.18 + + + + DiffFormula + C 4 H 9 N 1 O -1 S 1 + + + + DiffMono + 87.050656 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00536 + L-serine to L-alanine replacement + + OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue + + 179 + UniMod + + + + Ser_Ala + PSI-MOD-label + + + + DiffAvg + -16.00 + + + + DiffFormula + O -1 + + + + DiffMono + -15.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00537 + L-alanine residue (Thr) + + A protein modification that effectively converts an L-threonine residue to L-alanine. + + 659 + UniMod + + + This could represent either an engineered replacement or a chemical modification. + + Thr(Ala) + PSI-MOD-label + + + Thr->Ala + UniMod-interim + + + Thr->Ala substitution + UniMod-description + + + + DiffAvg + -30.03 + + + + DiffFormula + C -1 H -2 O -1 + + + + DiffMono + -30.010565 + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + T + + + + Source + none + + + + TermSpec + none + + MOD:00010 + MOD:00917 + PSI-MOD + + + MOD:00538 + protein modification categorized by isobaric sets + + Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00000 + PSI-MOD + + + MOD:00539 + threonine reduced to aminobutynate + + OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? modification from UniMod O-linked glycosylation + + 182 + UniMod + + + + + DiffAvg + -17.01 + + + + DiffFormula + H -1 O -1 + + + + DiffMono + -17.002740 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00540 + 9x(13)C labeled residue + + A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue. + + 12716131 + PubMed + + + 184 + UniMod + + + + 13C(9) Silac label + UniMod-description + + + Label:13C(9) + PSI-MS-label + + + + DiffAvg + 9.03 + + + + DiffFormula + (12)C -9 (13)C 9 + + + + DiffMono + 9.030194 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + PSI-MOD + + + MOD:00541 + 9x(13)C labeled L-phosphotyrosine + + A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine. + + 12716131 + PubMed + + + 185 + UniMod + + + + C13 label (Phosphotyrosine) + UniMod-description + + + Label:13C(9)+Phospho + PSI-MS-label + + + + DiffAvg + 89.00 + + + + DiffFormula + (12)C -9 (13)C 9 H 1 O 3 P 1 + + + + DiffMono + 88.996524 + + + + Formula + (13)C 9 H 10 N 1 O 5 P 1 + + + + MassAvg + 252.06 + + + + MassMono + 252.059853 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00540 + MOD:00919 + + derives_from + MOD:000480 + + PSI-MOD + + + MOD:00542 + hydroxyphenylglyoxal arginine + + modification from UniMod Chemical derivative + + 11698400 + PubMed + + + 11914093 + PubMed + + + 186 + UniMod + + + + HPG + PSI-MS-label + + + Hydroxyphenylglyoxal arginine + UniMod-description + + + + DiffAvg + 132.12 + + + + DiffFormula + C 8 H 4 O 2 + + + + DiffMono + 132.021129 + + + + Formula + C 14 H 16 N 4 O 3 + + + + MassAvg + 288.31 + + + + MassMono + 288.122240 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00543 + bis(hydroxyphenylglyoxal) arginine + + modification from UniMod Chemical derivative + + 11698400 + PubMed + + + 187 + UniMod + + + OH-PGO and PGO react with arginine at a stoichiometry of 2:1 [UniMod]. + + 2HPG + PSI-MS-label + + + bis(hydroxphenylglyoxal) arginine + UniMod-description + + + + DiffAvg + 282.25 + + + + DiffFormula + C 16 H 10 O 5 + + + + DiffMono + 282.052823 + + + + Formula + C 22 H 22 N 4 O 6 + + + + MassAvg + 438.44 + + + + MassMono + 438.153934 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00544 + 6x(13)C labeled residue + + A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue. + + 12716131 + PubMed + + + 188 + UniMod + + + PSI-MOD-slim + + 13C(6) Silac label + UniMod-description + + + Label:13C(6) + PSI-MS-label + + + + DiffAvg + 6.02 + + + + DiffFormula + (12)C -6 (13)C 6 + + + + DiffMono + 6.020129 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + PSI-MOD + + + MOD:00545 + deuterated dimethyl labeling (D) + + OBSOLETE because redundant with MOD:00927. Remap to MOD:00927. + + 14670044 + PubMed + + + + + DiffAvg + 34.07 + + + + DiffFormula + C 2 (1)H -2 (2)H 6 + + + + DiffMono + 34.068961 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + 1 + PSI-MOD + + + MOD:00546 + (18)O label at both C-terminal oxygens + + A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group. + + 11467524 + PubMed + + + 193 + UniMod + + + PSI-MOD-slim + + ctermpepdio18 + OMSSA-label + + + Label:18O(2) + PSI-MS-label + + + O18 label at both C-terminal oxygens + UniMod-description + + + + DiffAvg + 4.01 + + + + DiffFormula + (16)O -2 (18)O 2 + + + + DiffMono + 4.008493 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00847 + PSI-MOD + + + MOD:00547 + 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate + + modification from UniMod Chemical derivative + + 14997490 + PubMed + + + 194 + UniMod + + + + 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate + UniMod-description + + + AccQTag + PSI-MS-label + + + + DiffAvg + 170.17 + + + + DiffFormula + C 10 H 6 N 2 O 1 + + + + DiffMono + 170.048013 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00548 + APTA-d0 + + modification from UniMod Chemical derivative + + 15283597 + PubMed + + + 195 + UniMod + + + Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride [JSG]. + + APTA-d0 + UniMod-description + + + QAT + PSI-MS-label + + + + DiffAvg + 171.26 + + + + DiffFormula + C 9 H 19 N 2 O 1 + + + + DiffMono + 171.149738 + + + + Formula + C 12 H 24 N 3 O 2 S 1 + + + + MassAvg + 274.40 + + + + MassMono + 274.158923 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00549 + APTA d3 + + modification from UniMod Isotopic label + + 15283597 + PubMed + + + 196 + UniMod + + + Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG]. + + (3-acrylamidopropyl)trimethylammonium + UniMod-description + + + APTA d3 + UniMod-description + + + QAT:2H(3) + PSI-MS-label + + + + DiffAvg + 174.17 + + + + DiffFormula + C 9 (1)H 16 (2)H 3 N 2 O 1 + + + + DiffMono + 174.168568 + + + + Formula + C 12 (1)H 21 (2)H 3 N 3 O 2 S 1 + + + + MassAvg + 277.18 + + + + MassMono + 277.177753 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01431 + PSI-MOD + + + MOD:00550 + EAPTA d0 + + modification from UniMod Chemical derivative + + 197 + UniMod + + + + EAPTA d0 + UniMod-description + + + EQAT + PSI-MS-label + + + + DiffAvg + 184.28 + + + + DiffFormula + C 10 H 20 N 2 O 1 + + + + DiffMono + 184.157563 + + + + Formula + C 13 H 25 N 3 O 2 S 1 + + + + MassAvg + 287.42 + + + + MassMono + 287.166748 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00551 + EAPTA d5 + + modification from UniMod Isotopic label + + 198 + UniMod + + + + EAPTA d5 + UniMod-description + + + EQAT:2H(5) + PSI-MS-label + + + + DiffAvg + 189.19 + + + + DiffFormula + C 10 (1)H 15 (2)H 5 N 2 O 1 + + + + DiffMono + 189.188947 + + + + Formula + C 13 (1)H 20 (2)H 5 N 3 O 2 S 1 + + + + MassAvg + 292.20 + + + + MassMono + 292.198132 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01431 + PSI-MOD + + + MOD:00552 + 4x(2)H labeled dimethylated residue + + A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue. + + 14670044 + PubMed + + + 199 + UniMod + + + Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. + PSI-MOD-slim + + DiMethyl-CHD2 + UniMod-description + + + Dimethyl:2H(4) + PSI-MS-label + + + + DiffAvg + 32.06 + + + + DiffFormula + C 2 (2)H 4 + + + + DiffMono + 32.056407 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + PSI-MOD + + + MOD:00553 + 1,2-ethanedithiol modified residue + + A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group. + + 0 + DeltaMass + + + 11507762 + PubMed + + + 200 + UniMod + + + From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine. + + 1,2-ethanedithiol (EDT) + DeltaMass-label + + + EDT + UniMod-description + + + Ethanedithiol + PSI-MS-label + + + + DiffAvg + 76.18 + + + + DiffFormula + C 2 H 4 O -1 S 2 + + + + DiffMono + 75.980528 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00554 + APTA-d0 with no neutral loss + + OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative + + 202 + UniMod + + + + + DiffAvg + 170.26 + + + + DiffFormula + C 9 H 18 N 2 O 1 + + + + DiffMono + 170.141913 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00555 + APTA-d0 with quaternary amine loss + + OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative + + 203 + UniMod + + + + + DiffAvg + 170.26 + + + + DiffFormula + C 9 H 18 N 2 O 1 + + + + DiffMono + 170.141913 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00556 + acrolein addition +94 + + modification from UniMod Other + + 205 + UniMod + + + + Acrolein addition +94 + UniMod-description + + + Delta:H(6)C(6)O(1) + PSI-MS-label + + + + DiffAvg + 94.11 + + + + DiffFormula + C 6 H 6 O 1 + + + + DiffMono + 94.041865 + + + + Formula + C 12 H 18 N 2 O 2 + + + + MassAvg + 222.29 + + + + MassMono + 222.136828 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00557 + acrolein addition +56 + + modification from UniMod Other + + 10825247 + PubMed + + + 15541752 + PubMed + + + 206 + UniMod + + + + Acrolein addition +56 + UniMod-description + + + Delta:H(4)C(3)O(1) + PSI-MS-label + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00558 + acrolein addition +38 + + modification from UniMod Other + + 207 + UniMod + + + + Acrolein addition +38 + UniMod-description + + + Delta:H(2)C(3) + PSI-MS-label + + + + DiffAvg + 38.05 + + + + DiffFormula + C 3 H 2 + + + + DiffMono + 38.015650 + + + + Formula + C 9 H 14 N 2 O 1 + + + + MassAvg + 166.22 + + + + MassMono + 166.110613 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00559 + acrolein addition +76 + + modification from UniMod Other + + 208 + UniMod + + + + Acrolein addition +76 + UniMod-description + + + Delta:H(4)C(6) + PSI-MS-label + + + + DiffAvg + 76.10 + + + + DiffFormula + C 6 H 4 + + + + DiffMono + 76.031300 + + + + Formula + C 12 H 16 N 2 O 1 + + + + MassAvg + 204.27 + + + + MassMono + 204.126263 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00560 + acrolein addition +112 + + modification from UniMod Other + + 209 + UniMod + + + + Acrolein addition +112 + UniMod-description + + + Delta:H(8)C(6)O(2) + PSI-MS-label + + + + DiffAvg + 112.13 + + + + DiffFormula + C 6 H 8 O 2 + + + + DiffMono + 112.052429 + + + + Formula + C 12 H 20 N 2 O 3 + + + + MassAvg + 240.30 + + + + MassMono + 240.147393 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00561 + N-ethyl iodoacetamide-d0 + + modification from UniMod Isotopic label + + 12766232 + PubMed + + + 211 + UniMod + + + + N-ethyl iodoacetamide-d0 + UniMod-description + + + NEIAA + PSI-MS-label + + + + DiffAvg + 85.11 + + + + DiffFormula + C 4 H 7 N 1 O 1 + + + + DiffMono + 85.052764 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00562 + N-ethyl iodoacetamide-d5 + + modification from UniMod Isotopic label + + 12766232 + PubMed + + + 212 + UniMod + + + + N-ethyl iodoacetamide-d5 + UniMod-description + + + NEIAA:2H(5) + PSI-MS-label + + + + DiffAvg + 90.08 + + + + DiffFormula + C 4 (1)H 2 (2)H 5 N 1 O 1 + + + + DiffMono + 90.084148 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01431 + PSI-MOD + + + MOD:00563 + N-acetylaminogalactosylated residue + + A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + GalNAcRes + PSI-MOD-label + + + HexNAc + PSI-MS-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00734 + MOD:01673 + PSI-MOD + + + MOD:00564 + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + + Modification from UniMod Isotopic label. The UniMod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497. + + 214 + UniMod + + + + iTRAQ4plex + UniMod-interim + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 O 1 + + + + DiffMono + 144.102062 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00565 + deglycosylated asparagine + + modification from UniMod N-linked glycosylation + + 7#N + UniMod + + + Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG]. + + Deamidated + UniMod-interim + + + Deamidation + UniMod-description + + + + DiffAvg + 0.98 + + + + DiffFormula + H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:00903 + PSI-MOD + + + MOD:00566 + label cysteine with IGBP reagent + + modification from UniMod Chemical derivative + + 243 + UniMod + + + "IDBEST tag for quantitation, http://www.targetdiscovery.com/index.php?topic=prod.idbe" + + IGBP + PSI-MS-label + + + Light IDBEST tag for quantitation + UniMod-description + + + + DiffAvg + 297.15 + + + + DiffFormula + Br 1 C 12 H 13 N 2 O 2 + + + + DiffMono + 296.016040 + + + + Formula + Br 1 C 15 H 18 N 3 O 3 S 1 + + + + MassAvg + 400.29 + + + + MassMono + 399.025225 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00567 + histidine oxidation to asparagine + + OBSOLETE because UniMod entry 244 is redundant with UniMod 348. Remap to MOD:00775. + + 29956 + ChEBI + + + 15736973 + PubMed + + + 5681232 + PubMed + + + 6692818 + PubMed + + + 9789001 + PubMed + + + AA0003 + RESID + + + 244 + UniMod + + + + + DiffAvg + -23.04 + + + + DiffFormula + C -2 H -1 N -1 O 1 + + + + DiffMono + -23.015984 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00568 + histidine oxidation to aspartic acid + + OBSOLETE because UniMod entry 245 is redundant with UniMod 349. Remap to MOD:00776 + + 1097438 + PubMed + + + 339692 + PubMed + + + 4399050 + PubMed + + + 5764436 + PubMed + + + 6692818 + PubMed + + + 8089117 + PubMed + + + 9521123 + PubMed + + + 9582379 + PubMed + + + 245 + UniMod + + + + + DiffAvg + -22.05 + + + + DiffFormula + C -2 H -2 N -2 O 2 + + + + DiffMono + -22.031969 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00569 + residues isobaric at a resolution below 0.000001 Da + + Natural or modified residues that are isobaric at a resolution below 0.000001 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00770 + PSI-MOD + + + MOD:00570 + residues isobaric at 71.037114 Da + + Natural or modified residues with a mass of 71.037114 Da. + + 18688235 + PubMed + + + MOD:00569 + MOD:00769 + PSI-MOD + + + MOD:00571 + 2-pyrrolidone-5-carboxylic acid (Pro) + + A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid. + + 9252331 + PubMed + + + 359 + UniMod + + + The review article PubMed:9252331 does not provide an original citation for this modification [JSG]. + + Pro->pyro-Glu + PSI-MS-label + + + PyrGlu(Pro) + PSI-MOD-label + + + Pyroglutamic + UniMod-interim + + + pyroglutamicp + OMSSA-label + + + + DiffAvg + 13.98 + + + + DiffFormula + H -2 O 1 + + + + DiffMono + 13.979265 + + + + Formula + C 5 H 6 N 1 O 2 + + + + MassAvg + 112.11 + + + + MassMono + 112.039853 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00679 + MOD:00915 + MOD:01048 + PSI-MOD + + + MOD:00572 + oxidized arginine biotinylated with biotin hydrazide + + modification from UniMod Chemical derivative + + 15174056 + PubMed + + + 15828771 + PubMed + + + 343 + UniMod + + + + Argbiotinhydrazide + UniMod-interim + + + oxidized Arginine biotinylated with biotin hydrazide + UniMod-description + + + + DiffAvg + 199.27 + + + + DiffFormula + C 9 H 13 N 1 O 2 S 1 + + + + DiffMono + 199.066700 + + + + Formula + C 15 H 25 N 5 O 3 S 1 + + + + MassAvg + 355.46 + + + + MassMono + 355.167811 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00573 + oxidized lysine biotinylated with biotin hydrazide + + modification from UniMod Chemical derivative + + 15174056 + PubMed + + + 353 + UniMod + + + "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" + + Lysbiotinhydrazide + UniMod-interim + + + oxidized Lysine biotinylated with biotin hydrazide + UniMod-description + + + + DiffAvg + 241.31 + + + + DiffFormula + C 10 H 15 N 3 O 2 S 1 + + + + DiffMono + 241.088498 + + + + Formula + C 16 H 27 N 5 O 3 S 1 + + + + MassAvg + 369.48 + + + + MassMono + 369.183461 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00574 + oxidized proline biotinylated with biotin hydrazide + + modification from UniMod Chemical derivative + + 15174056 + PubMed + + + 357 + UniMod + + + "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" + + oxidized proline biotinylated with biotin hydrazide + UniMod-description + + + probiotinhydrazide + UniMod-interim + + + + DiffAvg + 258.34 + + + + DiffFormula + C 10 H 18 N 4 O 2 S 1 + + + + DiffMono + 258.115047 + + + + Formula + C 15 H 25 N 5 O 3 S 1 + + + + MassAvg + 355.46 + + + + MassMono + 355.167811 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00575 + oxidized threonine biotinylated with biotin hydrazide + + modification from UniMod Chemical derivative + + 15174056 + PubMed + + + 361 + UniMod + + + "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" + + oxidized Threonine biotinylated with biotin hydrazide + UniMod-description + + + Thrbiotinhydrazide + UniMod-interim + + + + DiffAvg + 240.32 + + + + DiffFormula + C 10 H 16 N 4 O 1 S 1 + + + + DiffMono + 240.104482 + + + + Formula + C 14 H 23 N 5 O 3 S 1 + + + + MassAvg + 341.43 + + + + MassMono + 341.152161 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00576 + crotonaldehyde + + modification from UniMod Other + + 11283024 + PubMed + + + 253 + UniMod + + + + Crotonaldehyde + PSI-MS-label + + + Crotonaldehyde + UniMod-description + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 O 1 + + + + DiffMono + 70.041865 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00577 + acetaldehyde +26 + + modification from UniMod Other + + 7744761 + PubMed + + + 254 + UniMod + + + + Acetaldehyde +26 + UniMod-description + + + Delta:H(2)C(2) + PSI-MS-label + + + + DiffAvg + 26.04 + + + + DiffFormula + C 2 H 2 + + + + DiffMono + 26.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00578 + acetaldehyde +28 + + modification from UniMod Other + + 255 + UniMod + + + + Acetaldehyde +28 + UniMod-description + + + Delta:H(4)C(2) + PSI-MS-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00579 + propionaldehyde +40 + + modification from UniMod Other + + 256 + UniMod + + + + Delta:H(4)C(3) + PSI-MS-label + + + Propionaldehyde +40 + UniMod-description + + + + DiffAvg + 40.06 + + + + DiffFormula + C 3 H 4 + + + + DiffMono + 40.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00580 + propionaldehyde +42 + + OBSOLETE because entry removed from UniMod. Remap potentially to MOD:00579 propionaldehyde +40 + + 257 + UniMod + + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 + + + + DiffMono + 42.046950 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00581 + (18)O monosubstituted residue + + A protein modification that effectively substitutes one (18)O atom for one (16)O atom. + + 11467524 + PubMed + + + 258 + UniMod + + + PSI-MOD-slim + + ctermpepo18 + OMSSA-label + + + Label:18O(1) + PSI-MS-label + + + O18 Labeling + UniMod-description + + + + DiffAvg + 2.00 + + + + DiffFormula + (16)O -1 (18)O 1 + + + + DiffMono + 2.004246 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00845 + PSI-MOD + + + MOD:00582 + 6x(13)C,2x(15)N labeled L-lysine + + A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine. + + 12716131 + PubMed + + + 259 + UniMod + + + + 13C(6) 15N(2) Silac label + UniMod-description + + + Label:13C(6)15N(2) + PSI-MS-label + + + lys-13C615N2 + OMSSA-label + + + + DiffAvg + 8.01 + + + + DiffFormula + (12)C -6 (13)C 6 (14)N -2 (15)N 2 + + + + DiffMono + 8.014199 + + + + Formula + (13)C 6 H 12 (15)N 2 O 1 + + + + MassAvg + 136.11 + + + + MassMono + 136.109162 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + MOD:00843 + MOD:00912 + PSI-MOD + + + MOD:00583 + thiophosphorylated residue + + A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate'). + + 12110917 + PubMed + + + 260 + UniMod + + + + Thiophospho + PSI-MS-label + + + Thiophosphorylation + UniMod-description + + + + DiffAvg + 96.04 + + + + DiffFormula + H 1 O 2 P 1 S 1 + + + + DiffMono + 95.943487 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00860 + MOD:00861 + PSI-MOD + + + MOD:00584 + 4-sulfophenyl isothiocyanate derivatized residue + + A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate. + + 14689565 + PubMed + + + 14745769 + PubMed + + + 16526082 + PubMed + + + 261 + UniMod + + + + 4-sulfophenyl isothiocyanate + UniMod-description + + + SPITC + PSI-MS-label + + + + DiffAvg + 215.24 + + + + DiffFormula + C 7 H 5 N 1 O 3 S 2 + + + + DiffMono + 214.971085 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00841 + PSI-MOD + + + MOD:00585 + deuterium trisubstituted residue + + A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms. + + 262 + UniMod + + + + D(H)3Res + PSI-MOD-label + + + Label:2H(3) + PSI-MS-label + + + Trideuteration + UniMod-description + + + + DiffAvg + 3.02 + + + + DiffFormula + (1)H -3 (2)H 3 + + + + DiffMono + 3.018830 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00786 + PSI-MOD + + + MOD:00586 + phosphorylation to pyridyl thiol + + modification from UniMod Chemical derivative + + 264 + UniMod + + + + PET + PSI-MS-label + + + phosphorylation to pyridyl thiol + UniMod-description + + + + DiffAvg + 121.20 + + + + DiffFormula + C 7 H 7 N 1 O -1 S 1 + + + + DiffMono + 121.035006 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00587 + 6x(13)C,4x(15)N labeled L-arginine + + A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine. + + 12716131 + PubMed + + + 267 + UniMod + + + PSI-MOD-slim + + 13C(6) 15N(4) Silac label + UniMod-description + + + arg-13c6-15n4 + OMSSA-label + + + Label:13C(6)15N(4) + PSI-MS-label + + + + DiffAvg + 10.01 + + + + DiffFormula + (12)C -6 (13)C 6 (14)N -4 (15)N 4 + + + + DiffMono + 10.008269 + + + + Formula + (13)C 6 H 12 (15)N 4 O 1 + + + + MassAvg + 166.11 + + + + MassMono + 166.109380 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + MOD:00843 + MOD:00902 + PSI-MOD + + + MOD:00588 + 5x(13)C,1x(15)N labeled L-valine + + A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine. + + 12771378 + PubMed + + + 268#V + UniMod + + + + 13C(5) 15N(1) Silac label + UniMod-description + + + Label:13C(5)15N(1) + PSI-MS-label + + + + DiffAvg + 6.01 + + + + DiffFormula + (12)C -5 (13)C 5 (14)N -1 (15)N 1 + + + + DiffMono + 6.013809 + + + + Formula + (13)C 5 H 9 (15)N 1 O 1 + + + + MassAvg + 105.08 + + + + MassMono + 105.082223 + + + + Origin + V + + + + Source + artifact + + + + TermSpec + none + + MOD:00920 + MOD:01809 + PSI-MOD + + + MOD:00589 + 1x(13)C,1x(15)N labeled L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine. + + 12771378 + PubMed + + + 269 + UniMod + + + + 13C(9) 15N(1) Silac label + UniMod-description + + + Label:13C(9)15N(1) + PSI-MS-label + + + + DiffAvg + 10.03 + + + + DiffFormula + (12)C -9 (13)C 9 (14)N -1 (15)N 1 + + + + DiffMono + 10.027228 + + + + Formula + (13)C 9 H 9 (15)N 1 O 1 + + + + MassAvg + 157.10 + + + + MassMono + 157.095642 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + MOD:00843 + MOD:00914 + PSI-MOD + + + MOD:00590 + nucleophilic addtion to cytopiloyne + + modification from UniMod Chemical derivative + + 15549660 + PubMed + + + 270 + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00591 + nucleophilic addition to cytopiloyne+H2O + + modification from UniMod Chemical derivative + + 15549660 + PubMed + + + 271 + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00592 + sulfonation of N-terminal + + modification from UniMod Chemical derivative + + 12705581 + PubMed + + + 15732931 + PubMed + + + 16046801 + PubMed + + + 272 + UniMod + + + + CAF + PSI-MS-label + + + sulfonation of N-terminus + UniMod-description + + + + DiffAvg + 136.12 + + + + DiffFormula + C 3 H 4 O 4 S 1 + + + + DiffMono + 135.983030 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00003 + PSI-MOD + + + MOD:00593 + covalent modification of lysine by omega-maleimido alkanoyl N-hydroxysuccinimido esters + + modification from UniMod Chemical derivative + + 273 + UniMod + + + J. Prot. Chem. 2, 263-277, 1983 + + covalent modification of lysine by cross-linking reagent + UniMod-description + + + Xlink:SSD + PSI-MS-label + + + + DiffAvg + 253.25 + + + + DiffFormula + C 12 H 15 N 1 O 5 + + + + DiffMono + 253.095023 + + + + Formula + C 18 H 27 N 3 O 6 + + + + MassAvg + 381.43 + + + + MassMono + 381.189986 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00594 + residues isobaric at 113.047678 Da + + Natural or modified resiues with a mass of 113.047678 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00569 + MOD:00624 + PSI-MOD + + + MOD:00595 + mannosylated residue + + A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond + + 18688235 + PubMed + + + PSI-MOD-slim + + ManRes + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00434 + MOD:00727 + PSI-MOD + + + MOD:00596 + 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue + + A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS. + + 235 + DeltaMass + + + 8597590 + PubMed + + + 276 + UniMod + + + From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution. + + AEBS + PSI-MS-label + + + AEBSF + DeltaMass-label + + + Aminoethylbenzenesulfonylation + UniMod-description + + + + DiffAvg + 183.23 + + + + DiffFormula + C 8 H 9 N 1 O 2 S 1 + + + + DiffMono + 183.035400 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01652 + PSI-MOD + + + MOD:00597 + methyl methanethiosulfonate + + OBSOLETE because UniMod entry 277 redundant with UniMod 39. Remap to MOD:00110. + + 277 + UniMod + + + + + DiffAvg + 46.09 + + + + DiffFormula + C 1 H 2 S 1 + + + + DiffMono + 45.987721 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00598 + S-(2-hydroxyethyl)cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine + + 15351294 + PubMed + + + 278 + UniMod + + + This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG]. + PSI-MOD-slim + + Ethanolation of Cys + UniMod-description + + + Ethanolyl + PSI-MS-label + + + + DiffAvg + 44.05 + + + + DiffFormula + C 2 H 4 O 1 + + + + DiffMono + 44.026215 + + + + Formula + C 5 H 9 N 1 O 2 S 1 + + + + MassAvg + 147.19 + + + + MassMono + 147.035400 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00599 + monomethylated residue + + A protein modification that effectively replaces one hydrogen atom with one methyl group. + + 11875433 + PubMed + + + 34 + UniMod + + + PSI-MOD-slim + + Me1Res + PSI-MOD-label + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 + + + + DiffMono + 14.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00427 + PSI-MOD + + + MOD:00600 + L-glutamic acid 5-ethyl ester + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester. + + 0 + DeltaMass + + + 9629898 + PubMed + + + 280#E + UniMod + + + From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG]. + + Ethyl + DeltaMass-label + + + Ethyl + PSI-MS-label + + + Ethylation + UniMod-description + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + C 7 H 11 N 1 O 3 + + + + MassAvg + 157.17 + + + + MassMono + 157.073893 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00906 + MOD:01339 + PSI-MOD + + + MOD:00601 + cyclized residue + + A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain. + + 18688235 + PubMed + + + PSI-MOD-slim + + CycRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00602 + N-methylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + NMeRes + PSI-MOD-label + + MOD:00427 + PSI-MOD + + + MOD:00603 + N-ethylation + + OBSOLETE because UniMod entry 283 is redundant with UniMod 280. Remap to MOD:00600 + + 283 + UniMod + + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + 1 + PSI-MOD + + + MOD:00604 + 2x(2)H monomethylated L-lysine + + A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine. + + 15525938 + PubMed + + + 284 + UniMod + + + + Deuterium Methylation of Lysine + UniMod-description + + + Methyl:2H(2) + PSI-MS-label + + + + DiffAvg + 16.03 + + + + DiffFormula + C 1 (2)H 2 + + + + DiffMono + 16.028204 + + + + Formula + C 7 (1)H 12 (2)H 2 N 2 O 1 + + + + MassAvg + 144.12 + + + + MassMono + 144.123167 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00912 + + derives_from + MOD:000850 + + PSI-MOD + + + MOD:00605 + Sulfanilic Acid (SA), light C12 + + modification from UniMod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation + + 285 + UniMod + + + + Light Sulfanilic Acid (SA) C12 + UniMod-description + + + SulfanilicAcid + PSI-MS-label + + + + DiffAvg + 155.17 + + + + DiffFormula + C 6 H 5 N 1 O 2 S 1 + + + + DiffMono + 155.004099 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + C-term + + MOD:01426 + PSI-MOD + + + MOD:00606 + Sulfanilic Acid (SA), heavy C13 + + modification from UniMod Chemical derivative + + 9254591 + PubMed + + + 286 + UniMod + + + + Heavy Sulfanilic Acid (SA) C13 + UniMod-description + + + SulfanilicAcid:13C(6) + PSI-MS-label + + + + DiffAvg + 161.02 + + + + DiffFormula + (13)C 6 H 5 N 1 O 2 S 1 + + + + DiffMono + 161.024228 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + C-term + + MOD:01426 + PSI-MOD + + + MOD:00607 + dioxoindolealanine lactone + + modification from UniMod Chemical derivative + + 7949339 + PubMed + + + 288 + UniMod + + + UniMod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG]. + + Trp->Oxolactone + PSI-MS-label + + + Tryptophan oxidation to oxolactone + UniMod-description + + + + DiffAvg + 30.99 + + + + DiffFormula + H -1 O 2 + + + + DiffMono + 30.982004 + + + + Formula + C 11 H 9 N 2 O 3 + + + + MassAvg + 217.20 + + + + MassMono + 217.061317 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00918 + PSI-MOD + + + MOD:00608 + biotin polyethyleneoxide amine + + modification from UniMod Chemical derivative + + 289 + UniMod + + + + Biotin polyethyleneoxide amine + UniMod-description + + + Biotin-PEO-Amine + UniMod-interim + + + + DiffAvg + 356.49 + + + + DiffFormula + C 16 H 28 N 4 O 3 S 1 + + + + DiffMono + 356.188212 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00609 + Pierce EZ-Link Biotin-HPDP + + modification from UniMod Chemical derivative + + 290 + UniMod + + + + Biotin-HPDP + UniMod-interim + + + Pierce EZ-Link Biotin-HPDP + UniMod-description + + + + DiffAvg + 428.61 + + + + DiffFormula + C 19 H 32 N 4 O 3 S 2 + + + + DiffMono + 428.191583 + + + + Formula + C 22 H 37 N 5 O 4 S 3 + + + + MassAvg + 531.75 + + + + MassMono + 531.200768 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00610 + cysteinyl mercury + + modification from UniMod Chemical derivative + + 10695144 + PubMed + + + 291 + UniMod + + + + Delta:Hg(1) + PSI-MS-label + + + Mercury Mercaptan + UniMod-description + + + + DiffAvg + 200.59 + + + + DiffFormula + Hg 1 + + + + DiffMono + 201.970643 + + + + Formula + C 3 H 5 Hg 1 N 1 O 1 S 1 + + + + MassAvg + 303.73 + + + + MassMono + 304.979828 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + MOD:01075 + PSI-MOD + + + MOD:00611 + iodouridine monophosphate derivatized residue + + A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with a residue. + + 11112526 + PubMed + + + 11567090 + PubMed + + + 6540775 + PubMed + + + 292 + UniMod + + + + Cross-link of (Iodo)-uracil MP with W,F,Y + UniMod-description + + + IodoU-AMP + PSI-MS-label + + + + DiffAvg + 322.17 + + + + DiffFormula + C 9 H 11 N 2 O 9 P 1 + + + + DiffMono + 322.020217 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00612 + 3-(carboxamidomethylthio)propanoylated residue + + A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide. + + 15121203 + PubMed + + + 293 + UniMod + + + + 3-(carbamidomethylthio)propanoyl + UniMod-description + + + CAMthiopropanoyl + PSI-MS-label + + + + DiffAvg + 145.18 + + + + DiffFormula + C 5 H 7 N 1 O 2 S 1 + + + + DiffMono + 145.019749 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00649 + MOD:00848 + PSI-MOD + + + MOD:00613 + biotinoyl-iodoacetyl-ethylenediamine + + modification from UniMod Chemical derivative + + 10906242 + PubMed + + + 294 + UniMod + + + + biotinoyl-iodoacetyl-ethylenediamine + UniMod-description + + + IED-Biotin + PSI-MS-label + + + + DiffAvg + 326.42 + + + + DiffFormula + C 14 H 22 N 4 O 3 S 1 + + + + DiffMono + 326.141262 + + + + Formula + C 17 H 27 N 5 O 4 S 2 + + + + MassAvg + 429.55 + + + + MassMono + 429.150446 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00614 + fucosylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond. + + 11344537 + PubMed + + + 15189151 + PubMed + + + 295 + UniMod + + + PSI-MOD-slim + + dHex + PSI-MS-label + + + Fuc + PSI-MOD-label + + + Fucose + UniMod-description + + + + DiffAvg + 146.14 + + + + DiffFormula + C 6 H 10 O 4 + + + + DiffMono + 146.057909 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00736 + PSI-MOD + + + MOD:00615 + 4-sulfophenyl isothiocyante modification to N-term R + + OBSOLETE because entry UniMod:261 site N-term R was abandoned. Remap to MOD:00584 + + 261 site N-term R was abandoned. Remap to MOD:00584" [PubMed:14689565 + UniMod + + + 261 + UniMod + + + + + DiffAvg + 215.24 + + + + DiffFormula + C 7 H 5 N 1 O 3 S 2 + + + + DiffMono + 214.971085 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + R + + + + Source + artifact + + + + TermSpec + N-term + + 1 + PSI-MOD + + + MOD:00616 + residues isobaric at a resolution below 0.1 Da + + Natural or modified residues that are isobaric at a resolution below 0.1 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00538 + PSI-MOD + + + MOD:00617 + 3x(2)H residue methyl ester + + A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester. + + 298 + UniMod + + + + ctermpeptrideuteromethyl + OMSSA-label + + + deuterated methyl ester + UniMod-description + + + Methyl:2H(3) + PSI-MS-label + + + + DiffAvg + 17.03 + + + + DiffFormula + C 1 (1)H -1 (2)H 3 + + + + DiffMono + 17.034480 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + C-term + + MOD:00839 + PSI-MOD + + + MOD:00618 + tryptophan carboxylation + + modification from UniMod Chemical derivative + + 299#W + UniMod + + + There is no literature citation for this UniMod entry [JSG]. + + Carboxy + UniMod-interim + + + Carboxylation + UniMod-description + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 O 2 + + + + DiffMono + 43.989829 + + + + Formula + C 12 H 10 N 2 O 3 + + + + MassAvg + 230.22 + + + + MassMono + 230.069142 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00918 + MOD:01152 + PSI-MOD + + + MOD:00619 + hydroxylethanone + + OBSOLETE because entry 300 is redundant with UniMod 6 remap to MOD:01328 + + 300 + UniMod + + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00620 + cysteine monobromobimane derivative + + modification from UniMod Chemical derivative + + 7856876 + PubMed + + + 301 + UniMod + + + 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione, C 10 H 11 Br 1 N 2 O 2. + + Bromobimane + PSI-MS-label + + + Monobromobimane derivative + UniMod-description + + + + DiffAvg + 190.20 + + + + DiffFormula + C 10 H 10 N 2 O 2 + + + + DiffMono + 190.074228 + + + + Formula + C 13 H 15 N 3 O 3 S 1 + + + + MassAvg + 293.34 + + + + MassMono + 293.083412 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00621 + menadione quinone derivative + + modification from UniMod Chemical derivative + + 15939799 + PubMed + + + 302 + UniMod + + + + Menadione + UniMod-interim + + + Menadione quinone derivative + UniMod-description + + + + DiffAvg + 170.17 + + + + DiffFormula + C 11 H 6 O 2 + + + + DiffMono + 170.036779 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00622 + cysteine mercaptoethanol + + modification from UniMod Chemical derivative + + 80 + DeltaMass + + + 12442261 + PubMed + + + 303 + UniMod + + + From DeltaMass: Average Mass: 76 Average Mass Change:76 PubMed:8019414. + + Beta mercaptoethanol adduct + DeltaMass-label + + + Cysteine mercaptoethanol + UniMod-description + + + DeStreak + PSI-MS-label + + + + DiffAvg + 76.11 + + + + DiffFormula + C 2 H 4 O 1 S 1 + + + + DiffMono + 75.998286 + + + + Formula + C 5 H 9 N 1 O 2 S 2 + + + + MassAvg + 179.25 + + + + MassMono + 179.007471 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00623 + fucosylated biantennary (-2 galactose) + + modification from UniMod N-linked glycosylation + + 305 + UniMod + + + + dHex(1)Hex(3)HexNAc(4) + PSI-MS-label + + + Fucosylated biantennary (-2 galactose) + UniMod-description + + + + DiffAvg + 1443.33 + + + + DiffFormula + C 56 H 90 N 4 O 39 + + + + DiffMono + 1442.518219 + + + + Formula + C 60 H 96 N 6 O 41 + + + + MassAvg + 1557.43 + + + + MassMono + 1556.561147 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00624 + residues isobaric at 113.0-113.1 Da + + Natural or modified residues with a mass of 113.0-113.1 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00616 + PSI-MOD + + + MOD:00625 + N-methylmaleimide derivatized residue + + modification from UniMod Chemical derivative + + 314 + UniMod + + + + Nmethylmaleimide + PSI-MS-label + + + Nmethylmaleimide + UniMod-description + + + + DiffAvg + 111.10 + + + + DiffFormula + C 5 H 5 N 1 O 2 + + + + DiffMono + 111.032028 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00626 + fluorescein-5-thiosemicarbazide + + modification from UniMod Chemical derivative + + 2883911 + PubMed + + + 478 + UniMod + + + + fluorescein-5-thiosemicarbazide + UniMod-description + + + FTC + PSI-MS-label + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00627 + 2,5-dimethylpyrrole lysine from 2,5-hexanedione adduct + + modification from UniMod Chemical derivative + + 316 + UniMod + + + There is no citation for this UniMod entry. Add PubMed:7981420, correct spelling [JSG]. + + (2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid + PSI-MOD-alternate + + + 2,5-dimethypyrrole + UniMod-description + + + 6-(2,5-dimethylpyrrolidin-1-yl)norleucine + PSI-MOD-alternate + + + DimethylpyrroleAdduct + PSI-MS-label + + + + DiffAvg + 78.11 + + + + DiffFormula + C 6 H 6 + + + + DiffMono + 78.046950 + + + + Formula + C 12 H 18 N 2 O 1 + + + + MassAvg + 206.29 + + + + MassMono + 206.141913 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00912 + PSI-MOD + + + MOD:00628 + Hex2 + + a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds + + 18688235 + PubMed + + + + + DiffAvg + 324.28 + + + + DiffFormula + C 12 H 20 O 10 + + + + DiffMono + 324.105647 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:00629 + MDA adduct +62 + + modification from UniMod Chemical derivative + + 318 + UniMod + + + Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt]. + + Delta:H(2)C(5) + PSI-MS-label + + + MDA adduct +62 + UniMod-description + + + + DiffAvg + 62.07 + + + + DiffFormula + C 5 H 2 + + + + DiffMono + 62.015650 + + + + Formula + C 11 H 14 N 2 O 1 + + + + MassAvg + 190.25 + + + + MassMono + 190.110613 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00912 + PSI-MOD + + + MOD:00630 + C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. + + modification from UniMod Chemical derivative + + 9328283 + PubMed + + + 319 + UniMod + + + This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG] + + Delta:H(2)C(3)O(1) + PSI-MS-label + + + MDA adduct +54 + UniMod-description + + + + DiffAvg + 54.05 + + + + DiffFormula + C 3 H 2 O 1 + + + + DiffMono + 54.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00631 + hydrolyzed N-ethylmaleimide adduct + + modification from UniMod Chemical derivative + + 320 + UniMod + + + N-ethylmaeimide adduct + H20 (a mixture of isobaric products) [JSG]. + + Nethylmaleimide+water + PSI-MS-label + + + Nethylmaleimidehydrolysis + UniMod-description + + + + DiffAvg + 143.14 + + + + DiffFormula + C 6 H 9 N 1 O 3 + + + + DiffMono + 143.058243 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00632 + N-succinimide + + OBSOLETE because this chemical derivative modification from UniMod 321 is deprecated. + + 321 + UniMod + + + + + DiffAvg + -17.01 + + + + DiffFormula + H -1 O -1 + + + + DiffMono + -17.002740 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00633 + bis-N-I-sulfonerahodamine + + modification from UniMod Chemical derivative + + 323 + UniMod + + + Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [UniMod]. + + bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine + PSI-MOD-alternate + + + bis-N-I-sulfonerahodamine + UniMod-description + + + Xlink:B10621 + PSI-MS-label + + + + DiffAvg + 713.57 + + + + DiffFormula + C 31 H 30 I 1 N 4 O 6 S 1 + + + + DiffMono + 713.093078 + + + + Formula + C 34 H 35 I 1 N 5 O 7 S 2 + + + + MassAvg + 816.71 + + + + MassMono + 816.102263 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00634 + dimethyl 3,3'-dithiobispropionimidate + + modification from UniMod Chemical derivative + + 770170 + PubMed + + + 324 + UniMod + + + Pierce reagent, needs sites for N, Q, R, K, and N-term [JSG]. + + dimethyl 3,3'-dithiobispropionimidate + UniMod-description + + + DTBP + UniMod-interim + + + + DiffAvg + 123.60 + + + + DiffFormula + C 3 Cl 1 H 6 N 1 S 1 + + + + DiffMono + 122.990948 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00635 + 10-fluoroethoxyphosphinyl-N-(biotinamidopentyl)decanamide + + modification from UniMod Chemical derivative + + 10611275 + PubMed + + + 325 + UniMod + + + + 10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide + UniMod-description + + + FP-Biotin + UniMod-interim + + + + DiffAvg + 572.75 + + + + DiffFormula + C 27 H 49 N 4 O 5 P 1 S 1 + + + + DiffMono + 572.316128 + + + + Formula + C 30 H 54 N 5 O 7 P 1 S 1 + + + + MassAvg + 659.82 + + + + MassMono + 659.348157 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:00636 + S-ethylcysteine (Ser) + + A protein modification that effectively converts an L-serine residue to S-ethylcysteine. + + 327 + UniMod + + + Modification from UniMod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine. + + Delta:H(4)C(2)O(-1)S(1) + PSI-MS-label + + + S-Ethylcystine from Serine + UniMod-description + + + + DiffAvg + 44.11 + + + + DiffFormula + C 2 H 4 O -1 S 1 + + + + DiffMono + 44.008457 + + + + Formula + C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 131.19 + + + + MassMono + 131.040485 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + PSI-MOD + + + MOD:00637 + 1x(13)C,3x(2)H labeled monomethylated L-arginine + + A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine. + + 329 + UniMod + + + + Methyl:2H(3)13C(1) + PSI-MS-label + + + monomethylated arginine + UniMod-description + + + + DiffAvg + 18.04 + + + + DiffFormula + (13)C 1 (1)H -1 (2)H 3 + + + + DiffMono + 18.037835 + + + + Formula + (12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1 + + + + MassAvg + 174.14 + + + + MassMono + 174.138946 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00842 + MOD:00902 + + derives_from + MOD:004140 + + PSI-MOD + + + MOD:00638 + 2x(13)C,6x(2)H labeled dimethylated L-arginine + + A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine. + + 15782174 + PubMed + + + 330 + UniMod + + + + Dimethyl:2H(6)13C(2) + PSI-MS-label + + + dimethylated arginine + UniMod-description + + + + DiffAvg + 36.08 + + + + DiffFormula + (13)C 2 (1)H -2 (2)H 6 + + + + DiffMono + 36.075670 + + + + Formula + (12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1 + + + + MassAvg + 192.18 + + + + MassMono + 192.176781 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00842 + MOD:00902 + + derives_from + MOD:007830 + + PSI-MOD + + + MOD:00639 + thiophosphate labeled with biotin-HPDP + + modification from UniMod Chemical derivative + + 332 + UniMod + + + + Thiophos-S-S-biotin + PSI-MS-label + + + thiophosphate labeled with biotin-HPDP + UniMod-description + + + + DiffAvg + 525.66 + + + + DiffFormula + C 19 H 34 N 4 O 5 P 1 S 3 + + + + DiffMono + 525.142895 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00861 + PSI-MOD + + + MOD:00640 + 6-N-biotinylaminohexyl isopropyl phosphorofluoridate + + modification from UniMod Chemical derivative + + 333 + UniMod + + + + 6-N-biotinylaminohexyl isopropyl phosphate + UniMod-description + + + Can-FP-biotin + UniMod-interim + + + + DiffAvg + 467.54 + + + + DiffFormula + C 19 F 1 H 35 N 3 O 5 P 1 S 1 + + + + DiffMono + 467.201907 + + + + Formula + C 22 F 1 H 40 N 4 O 7 P 1 S 1 + + + + MassAvg + 554.62 + + + + MassMono + 554.233935 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:00641 + CAMthiopropanoyl of Lys + + OBSOLETE because UniMod entry 334 is merged with UniMod 293. Remap to MOD:00612 + + 334 + UniMod + + + + + DiffAvg + 146.18 + + + + DiffFormula + C 5 H 8 N 1 O 2 S 1 + + + + DiffMono + 146.027574 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00642 + reduced 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. + + 11910026 + PubMed + + + 15133838 + PubMed + + + 335 + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + HNE+Delta:H(2) + PSI-MS-label + + + reduced 4-Hydroxynonenal + UniMod-description + + + + DiffAvg + 158.24 + + + + DiffFormula + C 9 H 18 O 2 + + + + DiffMono + 158.130680 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:01155 + + derives_from + MOD:004460 + + PSI-MOD + + + MOD:00643 + methylamine Michael addition derivatized residue + + modification from UniMod Artifact + + 11968134 + PubMed + + + 337 + UniMod + + + + Methylamine + PSI-MS-label + + + Michael addition with methylamine + UniMod-description + + + + DiffAvg + 13.04 + + + + DiffFormula + C 1 H 3 N 1 O -1 + + + + DiffMono + 13.031634 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00003 + PSI-MOD + + + MOD:00644 + O-acetylated residue + + A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group. + + 18688235 + PubMed + + + PSI-MOD-slim + + OAcRes + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00394 + MOD:00671 + PSI-MOD + + + MOD:00645 + S-acetylated residue + + A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + SAcRes + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 O 1 S 0 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00394 + MOD:00672 + PSI-MOD + + + MOD:00646 + acetylated L-cysteine + + A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine. + + 18688235 + PubMed + + + PSI-MOD-slim + + AcCys + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 S 0 + + + + DiffMono + 42.010565 + + + + Formula + C 5 H 7 N 1 O 2 S 1 + + + + MassAvg + 145.18 + + + + MassMono + 145.019749 + + + + Origin + C + + + + Source + natural + + MOD:00394 + MOD:00905 + PSI-MOD + + + MOD:00647 + acetylated L-serine + + A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine. + + 18688235 + PubMed + + + PSI-MOD-slim + + AcSer + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + S + + + + Source + natural + + MOD:00394 + MOD:00916 + PSI-MOD + + + MOD:00648 + N,O-diacetylated L-serine + + A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine. + + 16731519 + PubMed + + + 489587 + PubMed + + + 7309355 + PubMed + + + AA0051#var + RESID + + + AA0364#var + RESID + + + The samples were prepared using glacial acetic acid, and were probably artifactual [JSG]. + + (S)-2-acetamido-3-acetyloxypropanoic acid + PSI-MOD-alternate + + + N,O-diacetyl-L-serine + PSI-MOD-alternate + + + N,O-diacetylserine + PSI-MOD-alternate + + + NOAc2Ser + PSI-MOD-label + + + + DiffAvg + 84.07 + + + + DiffFormula + C 4 H 4 N 0 O 2 + + + + DiffMono + 84.021129 + + + + Formula + C 7 H 10 N 1 O 4 + + + + MassAvg + 172.16 + + + + MassMono + 172.060983 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00408 + MOD:00644 + MOD:00647 + + has_functional_parent + MOD:000600 + + + has_functional_parent + MOD:003690 + + PSI-MOD + + + MOD:00649 + acylated residue + + A protein modification that effectively replaces a hydrogen atom with an acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + AcylRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00650 + N-myristoylated residue + + A protein modification that effectively replaces a residue amino group with a myristoylamino group. + + 18688235 + PubMed + + + PSI-MOD-slim + + NMyrRes + PSI-MOD-label + + + + DiffAvg + 210.36 + + + + DiffFormula + C 14 H 26 O 1 + + + + DiffMono + 210.198365 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00438 + MOD:00670 + PSI-MOD + + + MOD:00651 + N-palmitoylated residue + + A protein modification that effectively replaces a residue amino group with a palmitoylamino group. + + 18688235 + PubMed + + + PSI-MOD-slim + + NPamRes + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 O 1 + + + + DiffMono + 238.229666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00440 + MOD:00670 + PSI-MOD + + + MOD:00652 + O-palmitoylated residue + + A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group. + + 18688235 + PubMed + + + PSI-MOD-slim + + OPamRes + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 O 1 + + + + DiffMono + 238.229666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00440 + MOD:00671 + PSI-MOD + + + MOD:00653 + S-palmitoylated residue + + A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + SPamRes + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00440 + MOD:00672 + PSI-MOD + + + MOD:00654 + S-methylated residue + + a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group + + 18688235 + PubMed + + + PSI-MOD-slim + + SMeRes + PSI-MOD-label + + MOD:00427 + PSI-MOD + + + MOD:00655 + S-myristoylated residue + + A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group. + + 18688235 + PubMed + + + + SMyrRes + PSI-MOD-label + + + + DiffAvg + 210.36 + + + + DiffFormula + C 14 H 26 O 1 S 0 + + + + DiffMono + 210.198365 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00438 + MOD:00672 + PSI-MOD + + + MOD:00656 + C-methylated residue + + A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group. + + 18688235 + PubMed + + + + CMeRes + PSI-MOD-label + + MOD:00427 + PSI-MOD + + + MOD:00657 + L-glutamic acid 5-methyl ester (Gln) + + A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester. + + 16888 + PubMed + + + 6300110 + PubMed + + + AA0072#GLN + RESID + + + 528 + UniMod + + + This is known to be a natural modification of glutamine in prokaryotes. + PSI-MOD-slim + + (2S)-2-amino-5-methoxy-5-oxopentanoic acid + RESID-systematic + + + (5)-methyl L-hydrogen glutamate + RESID-alternate + + + 2-aminopentanedioic acid 5-methyl ester + RESID-alternate + + + 5-methyl L-2-aminoglutarate + RESID-alternate + + + 5-methyl L-glutamate + RESID-alternate + + + deamidated 5-methyl esterified glutamine + PSI-MOD-alternate + + + Deamidation followed by a methylation + UniMod-description + + + glutamic acid 5-methyl ester + RESID-alternate + + + glutamic acid gamma-methyl ester + RESID-alternate + + + L-glutamic acid 5-methyl ester + RESID-name + + + Methyl+Deamidated + PSI-MS-label + + + MOD_RES Glutamate methyl ester (Gln) + UniProt-feature + + + O5MeGlu(Gln) + PSI-MOD-label + + + + DiffAvg + 15.01 + + + + DiffFormula + C 1 H 1 N -1 O 1 + + + + DiffMono + 14.999666 + + + + Formula + C 6 H 9 N 1 O 3 + + + + MassAvg + 143.14 + + + + MassMono + 143.058243 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:01369 + MOD:01453 + + has_functional_parent + MOD:006590 + + PSI-MOD + + + MOD:00658 + methylated arginine + + A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeArg + PSI-MOD-label + + + + Origin + R + + MOD:00427 + MOD:00902 + PSI-MOD + + + MOD:00659 + methylated glutamine + + A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeGln + PSI-MOD-label + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00907 + PSI-MOD + + + MOD:00660 + methylated cysteine + + A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeCys + PSI-MOD-label + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00905 + PSI-MOD + + + MOD:00661 + methylated histidine + + A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeHis + PSI-MOD-label + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00909 + PSI-MOD + + + MOD:00662 + methylated leucine + + A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeLeu + PSI-MOD-label + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00911 + PSI-MOD + + + MOD:00663 + methylated lysine + + A protein modification that effectively converts an L-lysine residue to a methylated lysine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeLys + PSI-MOD-label + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00912 + PSI-MOD + + + MOD:00664 + stereoisomerized residue + + A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer. + + 18688235 + PubMed + + + + D-Res + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00665 + methylated alanine + + A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeAla + PSI-MOD-label + + + + Origin + A + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00901 + PSI-MOD + + + MOD:00666 + octanoylated residue + + A protein modification that effectively replaces a hydrogen atom with an octanoyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + OctRes + PSI-MOD-label + + + + DiffAvg + 126.20 + + + + DiffFormula + C 8 H 14 N 0 O 1 + + + + DiffMono + 126.104465 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00649 + MOD:01155 + PSI-MOD + + + MOD:00667 + decanoylated residue + + A protein modification that effectively replaces a hydrogen atom with a decanoyl group. + + 18688235 + PubMed + + + + DecRes + PSI-MOD-label + + + + DiffAvg + 154.25 + + + + DiffFormula + C 10 H 18 N 0 O 1 + + + + DiffMono + 154.135765 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00649 + MOD:01155 + PSI-MOD + + + MOD:00668 + O-decanoylated residue + + A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group. + + 449 + UniMod + + + + Decanoyl + PSI-MS-label + + + lipid + UniMod-description + + + ODecRes + PSI-MOD-label + + + + DiffAvg + 154.25 + + + + DiffFormula + C 10 H 18 N 0 O 1 + + + + DiffMono + 154.135765 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00667 + MOD:00671 + PSI-MOD + + + MOD:00669 + O-octanoylated residue + + A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group. + + 426 + UniMod + + + PSI-MOD-slim + + Octanoyl + PSI-MS-label + + + octanoyl + UniMod-description + + + OOctRes + PSI-MOD-label + + + + DiffAvg + 126.20 + + + + DiffFormula + C 8 H 14 N 0 O 1 + + + + DiffMono + 126.104465 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00666 + MOD:00671 + PSI-MOD + + + MOD:00670 + N-acylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + NAcylRes + PSI-MOD-label + + MOD:00649 + PSI-MOD + + + MOD:00671 + O-acylated residue + + A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group. + + 18688235 + PubMed + + + PSI-MOD-slim + + OAcylRes + PSI-MOD-label + + MOD:00649 + PSI-MOD + + + MOD:00672 + S-acylated residue + + A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + SAcylRes + PSI-MOD-label + + MOD:00649 + PSI-MOD + + + MOD:00673 + methylated asparagine + + A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeAsn + PSI-MOD-label + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00903 + PSI-MOD + + + MOD:00674 + amidated residue + + A protein modification that effectively replaces a carboxyl group with a carboxamido group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00675 + oxidized residue + + A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + OxRes + PSI-MOD-label + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00676 + oxygenated residue + + A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + OxyRes + PSI-MOD-label + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00675 + PSI-MOD + + + MOD:00677 + hydroxylated residue + + A protein modification that effectively replaces a hydrogen atom with an hydroxyl group. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 16 + PSI-MOD-slim + + Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate) + DeltaMass-label + + + HyRes + PSI-MOD-label + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00679 + PSI-MOD + + + MOD:00678 + hydroxylated proline + + A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline. + + 18688235 + PubMed + + + PSI-MOD-slim + + HyPro + PSI-MOD-label + + + + Origin + P + + + + Source + none + + + + TermSpec + none + + MOD:00677 + MOD:00915 + PSI-MOD + + + MOD:00679 + carbon oxygenated residue + + A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + COxyRes + PSI-MOD-label + + MOD:00676 + PSI-MOD + + + MOD:00680 + sulfur oxygenated residue + + A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + SOxyRes + PSI-MOD-label + + MOD:00676 + PSI-MOD + + + MOD:00681 + hydroxylated lysine + + A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine. + + 18688235 + PubMed + + + PSI-MOD-slim + + HyLys + PSI-MOD-label + + + + Origin + K + + MOD:00677 + MOD:00912 + PSI-MOD + + + MOD:00682 + hydroxylated arginine + + A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine. + + 18688235 + PubMed + + + + HyArg + PSI-MOD-label + + + + Origin + R + + MOD:00677 + MOD:00902 + PSI-MOD + + + MOD:00683 + dehydrogenated residue + + A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + dHRes + PSI-MOD-label + + + + Origin + X + + MOD:00675 + PSI-MOD + + + MOD:00684 + deamidated L-asparagine + + A protein modification that effectively converts an L-asparagine residue to L-aspartic acid. + + 1097438 + PubMed + + + 339692 + PubMed + + + 4399050 + PubMed + + + 5764436 + PubMed + + + 6692818 + PubMed + + + 8089117 + PubMed + + + 9521123 + PubMed + + + 9582379 + PubMed + + + AA0004#ASN + RESID + + + 7#N + UniMod + + + incidental to RESID:AA0059 + PSI-MOD-slim + + (2S)-2-aminobutanedioic acid + RESID-systematic + + + 2-azanylbutanedioic acid + RESID-alternate + + + aminosuccinic acid + RESID-alternate + + + dNAsn + PSI-MOD-label + + + L-aspartic acid + RESID-name + + + MOD_RES Deamidated asparagine + UniProt-feature + + + + DiffAvg + 0.98 + + + + DiffFormula + C 0 H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00013 + MOD:00400 + MOD:00903 + PSI-MOD + + + MOD:00685 + deamidated L-glutamine + + A protein modification that effectively converts an L-glutamine residue to L-glutamic acid. + + 1881881 + PubMed + + + 4565668 + PubMed + + + 4922541 + PubMed + + + 6692818 + PubMed + + + 9192900 + PubMed + + + 957425 + PubMed + + + AA0006#GLN + RESID + + + 7#Q + UniMod + + + PSI-MOD-slim + + (2S)-2-aminopentanedioic acid + RESID-systematic + + + 1-aminopropane-1,3-dicarboxylic acid + RESID-alternate + + + 2-aminoglutaric acid + RESID-alternate + + + 2-azanylpentanedioic acid + RESID-alternate + + + alpha-aminoglutaric acid + RESID-alternate + + + dNGln + PSI-MOD-label + + + glutaminic acid + RESID-alternate + + + L-glutamic acid + RESID-name + + + MOD_RES Deamidated glutamine + UniProt-feature + + + + DiffAvg + 0.98 + + + + DiffFormula + C 0 H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00015 + MOD:00400 + PSI-MOD + + + MOD:00686 + L-selenocysteine (Cys) + + A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process). + + 10523135 + PubMed + + + 2037562 + PubMed + + + 2963330 + PubMed + + + 6217842 + PubMed + + + 6714945 + PubMed + + + AA0022#CYS + RESID + + + 162#C + UniMod + + + This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG]. + + (2R)-2-amino-3-selanylpropanoic acid + RESID-systematic + + + 2-azanyl-3-selanylpropanoic acid + RESID-alternate + + + 3-selenylalanine + RESID-alternate + + + L-selenocysteine + RESID-name + + + NON_STD Selenocysteine + UniProt-feature + + + Sec(Cys) + PSI-MOD-label + + + SeCys + RESID-alternate + + + selenium cysteine + RESID-alternate + + + + DiffAvg + 46.91 + + + + DiffFormula + C 0 H 0 N 0 O 0 S -1 Se 1 + + + + DiffMono + 47.944450 + + + + Formula + C 3 H 5 N 1 O 1 Se 1 + + + + MassAvg + 150.05 + + + + MassMono + 150.953635 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00007 + MOD:00031 + MOD:00905 + PSI-MOD + + + MOD:00687 + thioether crosslinked residues + + A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine. + + 18688235 + PubMed + + + MOD:00033 + MOD:00905 + PSI-MOD + + + MOD:00688 + isopeptide crosslinked residues + + A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + PSI-MOD + + + MOD:00689 + disulfide crosslinked residues + + A protein modification that crosslinks two cysteine residues by formation of a disulfide bond. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01619 + PSI-MOD + + + MOD:00690 + oxazole/thiazole ring crosslinked residues + + A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring. + + 18688235 + PubMed + + + MOD:00033 + PSI-MOD + + + MOD:00691 + 5-imidazolinone ring crosslinked residues + + A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring. + + 18688235 + PubMed + + + MOD:00033 + PSI-MOD + + + MOD:00692 + uncategorized crosslinked residues + + A protein crosslink modification that is not chemically categorized. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + PSI-MOD + + + MOD:00693 + glycosylated residue + + A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + GlycoRes + PSI-MOD-label + + + + Source + natural + + MOD:00764 + PSI-MOD + + + MOD:00694 + halogen containing residue + + A protein modification that effectively substitutes a halogen atom for a hydrogen atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + halogenated residue + PSI-MOD-alternate + + + HalRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00695 + sulfated residue + + A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group. + + 0 + DeltaMass + + + 14752058 + PubMed + + + 40 + UniMod + + + From DeltaMass: Average Mass: 80. + PSI-MOD-slim + + O-Sulfonation + UniMod-description + + + Sulfo + PSI-MS-label + + + SulfRes + PSI-MOD-label + + + Sulphonation (SO3H) (of PMC group) + DeltaMass-label + + + + DiffAvg + 80.06 + + + + DiffFormula + O 3 S 1 + + + + DiffMono + 79.956815 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00860 + PSI-MOD + + + MOD:00696 + phosphorylated residue + + A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate'). + + 0 + DeltaMass + + + 21 + UniMod + + + From DeltaMass: Average Mass: 80. + PSI-MOD-slim + + Phospho + PSI-MS-label + + + Phosphorylation + UniMod-description + + + Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) + DeltaMass-label + + + PhosRes + PSI-MOD-label + + + + DiffAvg + 79.98 + + + + DiffFormula + H 1 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00861 + PSI-MOD + + + MOD:00697 + flavin modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a flavin group. + + 50 + UniMod + + + PSI-MOD-slim + + FAD + PSI-MS-label + + + Flavin adenine dinucleotide + UniMod-description + + + FlavRes + PSI-MOD-label + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 S 0 + + + + DiffMono + 783.141485 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00698 + metal or metal cluster containing modified residue + + A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion. + + 18688235 + PubMed + + + PSI-MOD-slim + + MetalRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00699 + porphyrin modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group. + + 18688235 + PubMed + + + PSI-MOD-slim + + PorphRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00700 + tetrapyrrole modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group. + + 18688235 + PubMed + + + + TetrapyrRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00701 + nucleotide or nucleic acid modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond. + + 18688235 + PubMed + + + PSI-MOD-slim + + NucRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00702 + isotope labeled residue + + A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common. + + 18688235 + PubMed + + + In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426. + PSI-MOD-slim + + IsoTagRes + PSI-MOD-label + + + SILAC + PSI-MOD-alternate + + MOD:01156 + PSI-MOD + + + MOD:00703 + isoprenylated residue + + A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group. + + 18688235 + PubMed + + + PSI-MOD-slim + + IpRes + PSI-MOD-label + + MOD:00001 + MOD:01155 + PSI-MOD + + + MOD:00704 + dehydrated residue + + A protein modification that effectively forms a double bond by removing a molecule of water from a residue. + + 0 + DeltaMass + + + 23 + UniMod + + + PSI-MOD-slim + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00705 + D-valine + + A protein modification that effectively converts an L-valine residue to D-valine. + + 30016 + ChEBI + + + 15853325 + PubMed + + + AA0200 + RESID + + + + (R)-2-amino-3-methylbutanoic acid + RESID-systematic + + + alpha-amino-beta-methylbutyric acid + RESID-alternate + + + alpha-aminoisovaleric acid + RESID-alternate + + + D-Val + PSI-MOD-label + + + D-valine + RESID-name + + + MOD_RES D-valine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 5 H 9 N 1 O 1 + + + + MassAvg + 99.13 + + + + MassMono + 99.068414 + + + + Origin + V + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + PSI-MOD + + + MOD:00706 + dehydrogenated tyrosine + + A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine. + + 401#Y + UniMod + + + PSI-MOD-slim + + dHTyr + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 9 H 7 N 1 O 2 + + + + MassAvg + 161.16 + + + + MassMono + 161.047678 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00919 + MOD:01888 + PSI-MOD + + + MOD:00707 + hydroxylated tyrosine + + a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine + + 18688235 + PubMed + + + PSI-MOD-slim + + HyTyr + PSI-MOD-label + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00677 + MOD:00919 + PSI-MOD + + + MOD:00708 + sulfur oxygenated L-cysteine + + A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + SOxyCys + PSI-MOD-label + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00680 + MOD:00905 + PSI-MOD + + + MOD:00709 + sulfur oxygenated L-methionine + + A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + SOxyMet + PSI-MOD-label + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00680 + MOD:00913 + PSI-MOD + + + MOD:00710 + protonated-dimethylated residue + + A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups. + + 18688235 + PubMed + + + For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation. + PSI-MOD-slim + + Me2+Res + PSI-MOD-label + + MOD:00429 + PSI-MOD + + + MOD:00711 + trimethylated protonated-residue + + A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group. + + 18688235 + PubMed + + + For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation. + PSI-MOD-slim + + Me3+Res + PSI-MOD-label + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 S 0 + + + + DiffMono + 43.054227 + + + + FormalCharge + 1+ + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00430 + PSI-MOD + + + MOD:00712 + methylated proline + + A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline. + + 18688235 + PubMed + + + PSI-MOD-slim + + MePro + PSI-MOD-label + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00915 + PSI-MOD + + + MOD:00713 + methylated glutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeGlu + PSI-MOD-label + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00906 + PSI-MOD + + + MOD:00714 + methylated glycine + + A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine. + + 18688235 + PubMed + + + + MeGly + PSI-MOD-label + + + + Origin + G + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00908 + PSI-MOD + + + MOD:00715 + methylated isoleucine + + A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine. + + 18688235 + PubMed + + + + MeIle + PSI-MOD-label + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00910 + PSI-MOD + + + MOD:00716 + methylated methionine + + A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeMet + PSI-MOD-label + + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:00427 + MOD:00913 + PSI-MOD + + + MOD:00717 + methylated phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MePhe + PSI-MOD-label + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00914 + PSI-MOD + + + MOD:00718 + methylated tyrosine + + A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine. + + 18688235 + PubMed + + + + MeTyr + PSI-MOD-label + + + + Origin + Y + + + + Source + natural + + + + TermSpec + N-term + + MOD:00427 + MOD:00919 + PSI-MOD + + + MOD:00719 + L-methionine sulfoxide + + A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues. + + 177 + DeltaMass + + + 21406390 + PubMed + + + 22116028 + PubMed + + + AA0581 + RESID + + + 35#M + UniMod + + + From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex. + PSI-MOD-slim + + (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid + RESID-systematic + + + L-methionine (R)-S-oxide + RESID-alternate + + + L-methionine (R)-sulfoxide + RESID-name + + + L-methionine S-oxide + PSI-MOD-alternate + + + L-methionine sulfoxide + PSI-MOD-alternate + + + Methionyl Sulfoxide + DeltaMass-label + + + MetO + PSI-MOD-label + + + MOD_RES Methionine (R)-sulfoxide + UniProt-feature + + + Oxidation + PSI-MS-label + + + oxym + OMSSA-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 S 0 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 9 N 1 O 2 S 1 + + + + MassAvg + 147.19 + + + + MassMono + 147.035400 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00709 + MOD:01854 + PSI-MOD + + + MOD:00720 + L-methionine (R)-sulfoxide + + A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer. + + 45764 + ChEBI + + + 21406390 + PubMed + + + 22116028 + PubMed + + + 23911929 + PubMed + + + AA0581 + RESID + + + + (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid + RESID-systematic + + + L-methionine (R)-S-oxide + RESID-alternate + + + L-methionine (R)-sulfoxide + RESID-name + + + MOD_RES Methionine (R)-sulfoxide + UniProt-feature + + + R-MetO + PSI-MOD-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 S 0 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 9 N 1 O 2 S 1 + + + + MassAvg + 147.19 + + + + MassMono + 147.035400 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:00719 + PSI-MOD + + + MOD:00721 + L-methionine (S)-sulfoxide + + A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer. + + 18688235 + PubMed + + + + S-MetO + PSI-MOD-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 S 0 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 9 N 1 O 2 S 1 + + + + MassAvg + 147.19 + + + + MassMono + 147.035400 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00719 + PSI-MOD + + + MOD:00722 + monomethylated L-glutamine + + A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group. + + 34#Q + UniMod + + + PSI-MOD-slim + + Me1Gln + PSI-MOD-label + + + methylq + OMSSA-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 10 N 2 O 2 + + + + MassAvg + 142.16 + + + + MassMono + 142.074228 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00599 + MOD:00659 + PSI-MOD + + + MOD:00723 + N-acetylated L-lysine + + A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine. + + 18688235 + PubMed + + + PSI-MOD-slim + + NAcLys + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 15 N 2 O 2 + + + + MassAvg + 171.22 + + + + MassMono + 171.113353 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00408 + MOD:00912 + PSI-MOD + + + MOD:00724 + N-methylated L-histidine + + A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group. + + 34#H + UniMod + + + PSI-MOD-slim + + Methyl + PSI-MS-label + + + methylh + OMSSA-label + + + NMeHis + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 9 N 3 O 1 + + + + MassAvg + 151.17 + + + + MassMono + 151.074562 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00599 + MOD:00602 + MOD:00661 + PSI-MOD + + + MOD:00725 + complex glycosylation + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond. + + 18688235 + PubMed + + + MOD:00693 + PSI-MOD + + + MOD:00726 + glucosylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond. + + 18688235 + PubMed + + + + Glc + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00727 + mannosylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond, + + 18688235 + PubMed + + + + Man + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00728 + galactosylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond. + + 18688235 + PubMed + + + + Gal + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00729 + pentosylated residue + + a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond + + 172 + DeltaMass + + + for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146 + + Pent + PSI-MOD-label + + + Pentoses (Ara, Rib, Xyl) + DeltaMass-label + + + Pentosyl + DeltaMass-label + + + + DiffAvg + 132.12 + + + + DiffFormula + C 5 H 8 O 4 + + + + DiffMono + 132.042259 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00730 + arabinosylated + + a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond + + 18688235 + PubMed + + + + Ara + PSI-MOD-label + + + + DiffAvg + 132.12 + + + + DiffFormula + C 5 H 8 O 4 + + + + DiffMono + 132.042259 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00729 + PSI-MOD + + + MOD:00731 + ribosylated + + a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond + + 18688235 + PubMed + + + + Rib + PSI-MOD-label + + + + DiffAvg + 132.12 + + + + DiffFormula + C 5 H 8 O 4 + + + + DiffMono + 132.042259 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00729 + PSI-MOD + + + MOD:00732 + xylosylated + + a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond + + 18688235 + PubMed + + + + Xyl + PSI-MOD-label + + + + DiffAvg + 132.12 + + + + DiffFormula + C 5 H 8 O 4 + + + + DiffMono + 132.042259 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00729 + PSI-MOD + + + MOD:00733 + N-acetylaminoglucosylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond. + + 18688235 + PubMed + + + + GlcNAc + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00436 + PSI-MOD + + + MOD:00734 + N-acetylaminogalactosylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond. + + 247 + DeltaMass + + + From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex + + GalNAc + PSI-MOD-label + + + N-acetylhexosamines (GalNAc, GlcNAc) + DeltaMass-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00436 + PSI-MOD + + + MOD:00735 + hexosuronylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond. + + 18688235 + PubMed + + + + HexA + PSI-MOD-label + + + + DiffAvg + 176.12 + + + + DiffFormula + C 6 H 8 O 6 + + + + DiffMono + 176.032088 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00736 + deoxyhexosylated + + a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 146 + PSI-MOD-slim + + Deoxyhexoses (Fuc, Rha) + DeltaMass-label + + + dHex + PSI-MOD-label + + + + DiffAvg + 146.14 + + + + DiffFormula + C 6 H 10 O 4 + + + + DiffMono + 146.057909 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00737 + N-acetylneuraminylated + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 291 + + N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA) + DeltaMass-label + + + NeuNAc + PSI-MOD-label + + + + DiffAvg + 291.26 + + + + DiffFormula + C 11 H 17 N 1 O 8 + + + + DiffMono + 291.095417 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00738 + iron containing modified residue + + A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion. + + 18688235 + PubMed + + + + FeRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00739 + iron-sulfur cluster containing modification + + A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms. + + 18688235 + PubMed + + + + FeSRes + PSI-MOD-label + + MOD:00738 + MOD:00860 + PSI-MOD + + + MOD:00740 + manganese containing modified residue + + A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion. + + 18688235 + PubMed + + + + MnRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00741 + nickel containing modified residue + + A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion. + + 18688235 + PubMed + + + + NiRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00742 + copper containing modified residue + + A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion. + + 18688235 + PubMed + + + + CuRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00743 + molybdenum containing modified residue + + A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion. + + 18688235 + PubMed + + + PSI-MOD-slim + + MoRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00744 + molybdenum pterin containing modification + + A protein modification containing a molybdenum atom in a pterin ring system. + + 18688235 + PubMed + + + PSI-MOD-slim + + MoPterRes + PSI-MOD-label + + MOD:00743 + MOD:00748 + PSI-MOD + + + MOD:00745 + selenium containing residue + + A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + SeRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00746 + tungsten containing modified residue + + A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion. + + 18688235 + PubMed + + + + WRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00747 + sodium containing modified residue + + A protein modification that effectively substitutes a sodium atom for a hydrogen atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + NaRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00748 + pterin modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a pterin group. + + 18688235 + PubMed + + + PSI-MOD-slim + + PterRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:00749 + sulfur substitution for oxygen + + A protein modification that effectively substitutes a sulfur atom for an oxygen atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + S(O)Res + PSI-MOD-label + + MOD:00860 + PSI-MOD + + + MOD:00750 + deoxyribonucleic acid linked residue + + A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond. + + 18688235 + PubMed + + + + DNARes + PSI-MOD-label + + MOD:00701 + PSI-MOD + + + MOD:00751 + ribonucleic acid linked residue + + a protein modification + + 18688235 + PubMed + + + + RNARes + PSI-MOD-label + + MOD:00701 + PSI-MOD + + + MOD:00752 + adenosine diphosphoribosyl (ADP-ribosyl) modified residue + + A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 541. + PSI-MOD-slim + + ADP-rybosylation (from NAD) + DeltaMass-label + + + ADPRibRes + PSI-MOD-label + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00701 + PSI-MOD + + + MOD:00753 + chlorinated residue + + A protein modification that effectively substitutes a chlorine atom for a hydrogen atom. + + 18688235 + PubMed + + + + ClRes + PSI-MOD-label + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00694 + PSI-MOD + + + MOD:00754 + brominated residue + + A protein modification that effectively substitutes a bromine atom for a hydrogen atom. + + 18688235 + PubMed + + + + BrRes + PSI-MOD-label + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00694 + PSI-MOD + + + MOD:00755 + iodinated residue + + A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + IRes + PSI-MOD-label + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00694 + PSI-MOD + + + MOD:00756 + 4-hydroxy-D-valine + + A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine. + + 15853325 + PubMed + + + AA0388 + RESID + + + + (2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid + RESID-systematic + + + 4-hydroxy-D-valine + RESID-name + + + D-4HyVal + PSI-MOD-label + + + D-gamma-hydroxyvaline + RESID-alternate + + + MOD_RES D-4-hydroxyvaline + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 9 N 1 O 2 + + + + MassAvg + 115.13 + + + + MassMono + 115.063329 + + + + Origin + V + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00664 + PSI-MOD + + + MOD:00757 + O4-galactosyl-L-hydroxyproline + + A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline. + + AA0389 + RESID + + + secondary to RESID:AA0030 + + (2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid + RESID-systematic + + + 4-(beta-D-galactopyranosyloxy)proline + RESID-alternate + + + 4-(galactosyloxy)proline + RESID-alternate + + + beta-galactopyranosyl-4-hydroxyproline + RESID-alternate + + + O4-galactosyl-L-hydroxyproline + RESID-name + + + O4-glycosyl-hydroxyproline + RESID-alternate + + + + DiffAvg + 178.14 + + + + DiffFormula + C 6 H 10 N 0 O 6 + + + + DiffMono + 178.047738 + + + + Formula + C 11 H 17 N 1 O 7 + + + + MassAvg + 275.26 + + + + MassMono + 275.100502 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00915 + PSI-MOD + + + MOD:00758 + O4-(N-acetylamino)glucosyl-L-hydroxyproline + + A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline. + + 15238247 + PubMed + + + 9660787 + PubMed + + + AA0390 + RESID + + + secondary to RESID:AA0030 + + (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid + RESID-systematic + + + 4-(N-acetylglucosaminyloxy)proline + RESID-alternate + + + 4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline + RESID-alternate + + + alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline + RESID-alternate + + + HexNAc + PSI-MS-label + + + O4-(N-acetylamino)glucosyl-L-hydroxyproline + RESID-name + + + O4-glycosyl-hydroxyproline + RESID-alternate + + + O4GlcNAcHyPro + PSI-MOD-label + + + + DiffAvg + 219.19 + + + + DiffFormula + C 8 H 13 N 1 O 6 + + + + DiffMono + 219.074287 + + + + Formula + C 13 H 20 N 2 O 7 + + + + MassAvg + 316.31 + + + + MassMono + 316.127051 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00448 + MOD:01677 + PSI-MOD + + + MOD:00759 + fucosylated biantennary (-1 galactose) + + modification from UniMod N-linked glycosylation + + 307 + UniMod + + + + dHex(1)Hex(4)HexNAc(4) + PSI-MS-label + + + Fucosylated biantennary (-1 galactose) + UniMod-description + + + + DiffAvg + 1607.48 + + + + DiffFormula + C 62 H 102 N 4 O 44 + + + + DiffMono + 1606.586693 + + + + Formula + C 66 H 108 N 6 O 46 + + + + MassAvg + 1721.59 + + + + MassMono + 1720.629620 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00760 + biantennary + + modification from UniMod N-linked glycosylation - missing ref + + 311 + UniMod + + + + Biantennary + UniMod-description + + + Hex(5)HexNAc(4) + PSI-MS-label + + + + DiffAvg + 1623.48 + + + + DiffFormula + C 62 H 102 N 4 O 45 + + + + DiffMono + 1622.581607 + + + + Formula + C 66 H 108 N 6 O 47 + + + + MassAvg + 1737.59 + + + + MassMono + 1736.624535 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00761 + monohexosylated (Hex1) + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond. + + 18688235 + PubMed + + + + Hex1 + PSI-MOD-alternate + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00434 + PSI-MOD + + + MOD:00762 + biantennary (-2 galactose) + + modification from UniMod N-linked glycosylation - missing ref + + 309 + UniMod + + + + Biantennary (-2 galactose) + UniMod-description + + + Hex(3)HexNAc(4) + PSI-MS-label + + + + DiffAvg + 1299.20 + + + + DiffFormula + C 50 H 82 N 4 O 35 + + + + DiffMono + 1298.475960 + + + + Formula + C 54 H 88 N 6 O 37 + + + + MassAvg + 1413.30 + + + + MassMono + 1412.518888 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00763 + biantennary (-1 galactose) + + modification from UniMod N-linked glycosylation - missing ref + + 310 + UniMod + + + + Biantennary (-1 galactose) + UniMod-description + + + Hex(4)HexNAc(4) + PSI-MS-label + + + + DiffAvg + 1461.34 + + + + DiffFormula + C 56 H 92 N 4 O 40 + + + + DiffMono + 1460.528784 + + + + Formula + C 60 H 98 N 6 O 42 + + + + MassAvg + 1575.44 + + + + MassMono + 1574.571711 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + MOD:00903 + PSI-MOD + + + MOD:00764 + glycoconjugated residue + + A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct. + + 18688235 + PubMed + + + 3743566 + PubMed + + + PSI-MOD-slim + MOD:01156 + PSI-MOD + + + MOD:00765 + cysteinylation (disulfide with free L-cysteine) + + A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine. + + 260 + DeltaMass + + + 1988019 + PubMed + + + 2001356 + PubMed + + + 2076469 + PubMed + + + 3083866 + PubMed + + + 366603 + PubMed + + + 7918467 + PubMed + + + 8344916 + PubMed + + + AA0025#CYS1 + RESID + + + 312 + UniMod + + + This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283 + PSI-MOD-slim + + (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) + RESID-systematic + + + 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid + RESID-misnomer + + + 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) + RESID-alternate + + + 3,3'-dithiobis(2-aminopropanoic acid) + RESID-alternate + + + 3,3'-dithiobisalanine + RESID-alternate + + + 3,3'-dithiodialanine + RESID-alternate + + + beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide + RESID-alternate + + + beta,beta'-dithiodialanine + RESID-alternate + + + bis(alpha-aminopropionic acid)-beta-disulfide + RESID-alternate + + + bis(beta-amino-beta-carboxyethyl)disulfide + RESID-alternate + + + Cysteinylation + DeltaMass-label + + + dicysteine + RESID-alternate + + + L-cystine + RESID-name + + + MOD_RES S-cysteinyl cysteine + UniProt-feature + + + S-cystenyl cystenyl + DeltaMass-label + + + SCysCys + PSI-MOD-label + + + + DiffAvg + 119.14 + + + + DiffFormula + C 3 H 5 N 1 O 2 S 1 + + + + DiffMono + 119.004099 + + + + Formula + C 6 H 10 N 2 O 3 S 2 + + + + MassAvg + 222.28 + + + + MassMono + 222.013284 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01862 + PSI-MOD + + + MOD:00766 + C terminal -K from HC of MAb + + modification from UniMod Post-translational - C-terminal loss of lysine + + 16078144 + PubMed + + + 313 + UniMod + + + + Loss of C-terminal K from Heavy Chain of MAb + UniMod-description + + + Lys-loss + PSI-MS-label + + + + DiffAvg + -128.18 + + + + DiffFormula + C -6 H -12 N -2 O -1 + + + + DiffMono + -128.094963 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + TermSpec + C-term + + MOD:00003 + PSI-MOD + + + MOD:00767 + glycated residue + + A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct. + + 18688235 + PubMed + + + + + Source + artifact + + MOD:00764 + PSI-MOD + + + MOD:00768 + methionine oxidation with neutral loss of 80 Da + + Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H. + + 18688235 + PubMed + + + 9004526 + PubMed + + + Originally created from UniMod:508 that was later deleted. + + + DiffAvg + -80.10 + + + + DiffFormula + C -1 H -4 N 0 O -2 S -1 + + + + DiffMono + -79.993200 + + + + Formula + C 4 H 5 N 1 O 1 S 0 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00431 + PSI-MOD + + + MOD:00769 + residues isobaric at 71.0-71.1 Da + + Natural or modified residues with a mass of 71.0-71.1 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00616 + PSI-MOD + + + MOD:00770 + residues isobaric at a resolution below 0.01 Da + + Natural or modified residues that are isobaric at a resolution below 0.01 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00616 + PSI-MOD + + + MOD:00771 + residues isobaric at 166.98-167.00 Da + + Natural or modified residues with a mass of 166.98-167.00 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00770 + PSI-MOD + + + MOD:00772 + vanadium containing modified residue + + A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion. + + 18688235 + PubMed + + + + VRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00773 + residues isobaric at 181.00-181.02 Da + + Natural or modified residues with a mass of 181.00-181.02 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00770 + PSI-MOD + + + MOD:00774 + residues isobaric at 243.02-243.03 Da + + Natural or modified residues with a mass of 243.02-243.03 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00770 + PSI-MOD + + + MOD:00775 + L-asparagine (His) + + An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation. + + 9252331 + PubMed + + + 348 + UniMod + + + + His->Asn + PSI-MS-label + + + his2asnh + OMSSA-label + + + histidine oxidation to aspargine + UniMod-description + + + + DiffAvg + -23.04 + + + + DiffFormula + C -2 H -1 N -1 O 1 + + + + DiffMono + -23.015984 + + + + Formula + C 4 H 6 N 2 O 2 + + + + MassAvg + 114.10 + + + + MassMono + 114.042927 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00012 + MOD:00909 + PSI-MOD + + + MOD:00776 + L-aspartic acid (His) + + An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation. + + 9252331 + PubMed + + + 349 + UniMod + + + From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG]. + + His->Asp + PSI-MS-label + + + his2asph + OMSSA-label + + + histidine oxidation to aspartic acid + UniMod-description + + + + DiffAvg + -22.05 + + + + DiffFormula + C -2 H -2 N -2 O 2 + + + + DiffMono + -22.031969 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00013 + MOD:00909 + PSI-MOD + + + MOD:00777 + residues isobaric at 182.96-182.98 Da + + Natural or modified residues with a mass of 182.96-182.98 Da. + + 18688235 + PubMed + + + MOD:00770 + MOD:00778 + PSI-MOD + + + MOD:00778 + residues isobaric at 182.9-183.0 Da + + Natural or modified residues with a mass of 182.9-183.0 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00616 + PSI-MOD + + + MOD:00779 + lysine oxidation to aminoadipic semialdehyde + + OBSOLETE because redundant with MOD:00130. Remap to MOD:00130. + + 352 + DeltaMass + + + 11332453 + PubMed + + + 358196 + PubMed + + + 5337886 + PubMed + + + 5529814 + PubMed + + + 352 + UniMod + + + From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. + + Oxidation of lysine (to aminoadipic semialdehyde) + DeltaMass-label + + + + DiffAvg + -1.03 + + + + DiffFormula + H -3 N -1 O 1 + + + + DiffMono + -1.031634 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00780 + N-acetyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine. + + 18688235 + PubMed + + + This modification has not been observed to occur naturally. + + AcAsn + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 6 H 8 N 2 O 3 + + + + MassAvg + 156.14 + + + + MassMono + 156.053492 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00903 + MOD:01458 + PSI-MOD + + + MOD:00781 + N2-acetyl-L-histidine + + A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine. + + 18688235 + PubMed + + + This modification has not been observed to occur naturally. + + AcHis + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 9 N 3 O 2 + + + + MassAvg + 179.18 + + + + MassMono + 179.069477 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00909 + MOD:01458 + PSI-MOD + + + MOD:00782 + N-acetyl-L-leucine + + A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine. + + 18688235 + PubMed + + + This modification has not been observed to occur naturally. + + AcLeu + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 8 H 14 N 1 O 2 + + + + MassAvg + 156.20 + + + + MassMono + 156.102454 + + + + Origin + L + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00911 + MOD:01458 + PSI-MOD + + + MOD:00783 + dimethylated L-arginine + + A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups. + + 36#R + UniMod + + + PSI-MOD-slim + + Dimethyl + PSI-MS-label + + + dimethylr + OMSSA-label + + + NNMe2Arg + PSI-MOD-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 4 O 1 + + + + MassAvg + 184.24 + + + + MassMono + 184.132411 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00429 + MOD:00658 + PSI-MOD + + + MOD:00784 + N-acetyl-L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine. + + 18688235 + PubMed + + + This modification has not been observed to occur naturally. + + AcPhe + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 11 H 11 N 1 O 2 + + + + MassAvg + 189.21 + + + + MassMono + 189.078979 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00914 + MOD:01458 + PSI-MOD + + + MOD:00785 + N2-acetyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan. + + 18688235 + PubMed + + + This modification has not been observed to occur naturally. + + AcTrp + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 13 H 12 N 2 O 2 + + + + MassAvg + 228.25 + + + + MassMono + 228.089878 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00918 + MOD:01458 + PSI-MOD + + + MOD:00786 + deuterium substituted residue + + A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + D(H)Res + PSI-MOD-label + + MOD:00839 + PSI-MOD + + + MOD:00787 + diisopropylphosphoserine + + modification from UniMod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin + + 362 + UniMod + + + + Diisopropylphosphate + UniMod-interim + + + O-Diisopropylphosphorylation + UniMod-description + + + + DiffAvg + 164.14 + + + + DiffFormula + C 6 H 13 O 3 P 1 + + + + DiffMono + 164.060231 + + + + Formula + C 9 H 18 N 1 O 5 P 1 + + + + MassAvg + 251.22 + + + + MassMono + 251.092259 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:00788 + isopropylphosphotyrosine + + modification from UniMod + + 363 + UniMod + + + + Isopropylphospho + UniMod-interim + + + O-Isopropylphosphorylation + UniMod-description + + + + DiffAvg + 122.06 + + + + DiffFormula + C 3 H 7 O 3 P 1 + + + + DiffMono + 122.013281 + + + + Formula + C 12 H 16 N 1 O 5 P 1 + + + + MassAvg + 285.24 + + + + MassMono + 285.076609 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00861 + MOD:00919 + PSI-MOD + + + MOD:00789 + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form + + modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. + + 15602776 + PubMed + + + 364 + UniMod + + + + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form + UniMod-description + + + ICPL:13C(6) + PSI-MS-label + + + + DiffAvg + 111.04 + + + + DiffFormula + (13)C 6 H 3 N 1 O 1 + + + + DiffMono + 111.041593 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00790 + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form + + modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. + + 15602776 + PubMed + + + 365 + UniMod + + + + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form + UniMod-description + + + ICPL + PSI-MS-label + + + + DiffAvg + 105.02 + + + + DiffFormula + (12)C 6 H 3 N 1 O 1 + + + + DiffMono + 105.021464 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + PSI-MOD + + + MOD:00791 + 1x(18)O labeled deamidated L-glutamine + + A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O. + + 8382902 + PubMed + + + 366#Q + UniMod + + + PSI-MOD-slim + + Deamidated:18O(1) + PSI-MS-label + + + Deamidation in presence of O18 + UniMod-description + + + + DiffAvg + 2.99 + + + + DiffFormula + H -1 N -1 (18)O 1 + + + + DiffMono + 2.988262 + + + + Formula + C 5 H 7 N 1 (16)O 2 (18)O 1 + + + + MassAvg + 131.05 + + + + MassMono + 131.046839 + + + + Origin + Q + + + + Source + artifact + + + + TermSpec + none + + MOD:00685 + MOD:00852 + PSI-MOD + + + MOD:00792 + deuterium monosubstituted residue + + A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + D(H)1Res + PSI-MOD-label + + MOD:00786 + PSI-MOD + + + MOD:00793 + dehydroalanine (Cys) + + A protein modification that effectively converts an L-cysteine residue to dehydroalanine. + + 17123 + ChEBI + + + 8 + DeltaMass + + + 10220322 + PubMed + + + 11212008 + PubMed + + + 1547888 + PubMed + + + 15799070 + PubMed + + + 1815586 + PubMed + + + 20805503 + PubMed + + + 2914619 + PubMed + + + 7947813 + PubMed + + + 8239649 + PubMed + + + AA0181#CYS + RESID + + + 368 + UniMod + + + From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG]. + PSI-MOD-slim + + 2,3-didehydroalanine + RESID-alternate + + + 2-aminoacrylic acid + RESID-alternate + + + 2-aminopropenoic acid + RESID-systematic + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + anhydroserine + RESID-alternate + + + Cys->Dha + PSI-MS-label + + + dehydroalanine + RESID-name + + + Dehydroalanine (from Cysteine) + DeltaMass-label + + + Dehydroalanine (from Cysteine) + UniMod-description + + + Dha + RESID-alternate + + + dHAla(Cys) + PSI-MOD-label + + + MOD_RES 2,3-didehydroalanine (Cys) + UniProt-feature + + + + DiffAvg + -34.08 + + + + DiffFormula + C 0 H -2 N 0 O 0 S -1 + + + + DiffMono + -33.987721 + + + + Formula + C 3 H 3 N 1 O 1 + + + + MassAvg + 69.06 + + + + MassMono + 69.021464 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01168 + PSI-MOD + + + MOD:00794 + pyrrolidone from proline + + OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477. + + 9252331 + PubMed + + + 369 + UniMod + + + This UniMod entry appears to have come from the same description in PubMed:9252331 as UniMod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657. + + Pro->Pyrrolidone + UniMod-interim + + + Pyrrolidone from Proline + UniMod-description + + + + DiffAvg + -28.01 + + + + DiffFormula + C -1 O -1 + + + + DiffMono + -27.994915 + + + + Formula + C 4 H 7 N 1 O 0 + + + + MassAvg + 69.11 + + + + MassMono + 69.057849 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00795 + Michael addition of hydroxymethylvinyl ketone to cysteine + + modification from UniMod + + 11743741 + PubMed + + + 371 + UniMod + + + + HMVK + PSI-MS-label + + + Michael addition of hydroxymethylvinyl ketone to cysteine + UniMod-description + + + + DiffAvg + 86.09 + + + + DiffFormula + C 4 H 6 O 2 + + + + DiffMono + 86.036779 + + + + Formula + C 7 H 11 N 1 O 3 S 1 + + + + MassAvg + 189.23 + + + + MassMono + 189.045964 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00796 + L-ornithine (Arg) + + A protein modification that effectively converts an L-arginine residue to L-ornithine. + + 129 + DeltaMass + + + 15489230 + PubMed + + + 372 + UniMod + + + PSI-MOD-slim + + Arg->Orn + PSI-MS-label + + + arg2orn + OMSSA-label + + + Ornithine (from Arginine) + DeltaMass-label + + + Ornithine from Arginine + UniMod-description + + + Ornithyl + DeltaMass-label + + + + DiffAvg + -42.04 + + + + DiffFormula + C -1 H -2 N -2 + + + + DiffMono + -42.021798 + + + + Formula + C 5 H 10 N 2 O 1 + + + + MassAvg + 114.15 + + + + MassMono + 114.079313 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00902 + PSI-MOD + + + MOD:00797 + 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal + + a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal + + 4696757 + PubMed + + + 7999765 + PubMed + + + 8664284 + PubMed + + + AA0391 + RESID + + + + (2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid + RESID-systematic + + + 2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid + RESID-alternate + + + 2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid + RESID-alternate + + + 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal + RESID-name + + + cysteinyl pyruvate O-phosphothioketal + RESID-alternate + + + MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal + UniProt-feature + + + phosphoenolpyruvate cysteine adduct + RESID-alternate + + + phospholactoyl cysteine adduct + RESID-alternate + + + S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine + RESID-alternate + + + SPEPCys + PSI-MOD-label + + + + DiffAvg + 168.04 + + + + DiffFormula + C 3 H 5 N 0 O 6 P 1 S 0 + + + + DiffMono + 167.982375 + + + + Formula + C 6 H 10 N 1 O 7 P 1 S 1 + + + + MassAvg + 271.18 + + + + MassMono + 270.991559 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00861 + MOD:00905 + PSI-MOD + + + MOD:00798 + half cystine + + A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed. + + 1988019 + PubMed + + + 2001356 + PubMed + + + 2076469 + PubMed + + + 3083866 + PubMed + + + 366603 + PubMed + + + 7918467 + PubMed + + + 8344916 + PubMed + + + 374 + UniMod + + + + Dehydro + PSI-MS-label + + + Half of a disulfide bridge + UniMod-description + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 S 0 + + + + DiffMono + -1.007825 + + + + Formula + C 3 H 4 N 1 O 1 S 1 + + + + MassAvg + 102.13 + + + + MassMono + 102.001360 + + + + Origin + C + + + + Source + none + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:00799 + S-galactosyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine. + + 11945907 + PubMed + + + AA0392 + RESID + + + The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid + RESID-systematic + + + S-(beta-D-galactopyranosyl)cysteine + RESID-alternate + + + S-galactosyl-L-cysteine + RESID-name + + + S-glycosyl-cysteine + RESID-alternate + + + SGalCys + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 S 0 + + + + DiffMono + 162.052823 + + + + Formula + C 9 H 15 N 1 O 6 S 1 + + + + MassAvg + 265.28 + + + + MassMono + 265.062008 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00426 + MOD:00476 + MOD:00761 + MOD:00905 + PSI-MOD + + + MOD:00800 + L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide + + A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide. + + 2345152 + PubMed + + + AA0393 + RESID + + + Cross-link 2; incidental to RESID:AA0300. + + CysHis-[V7Fe9S] + PSI-MOD-label + + + L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide + RESID-name + + + nitrogenase iron-vanadium cofactor + RESID-alternate + + + + DiffAvg + 932.51 + + + + DiffFormula + C 7 Fe 7 H 6 N 0 O 7 S 9 V 1 + + + + DiffMono + 932.248513 + + + + Formula + C 16 Fe 7 H 18 N 4 O 9 S 10 V 1 + + + + MassAvg + 1172.80 + + + + MassMono + 1172.316610 + + + + Origin + C, H + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00772 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00801 + L-cysteinyl-L-histidino-homocitryl octairon nonasulfide + + A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide. + + 8392330 + PubMed + + + AA0394 + RESID + + + Cross-link 2; incidental to RESID:AA0300. + + CysHis-[8Fe9S] + PSI-MOD-label + + + L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide + RESID-name + + + nitrogenase iron-iron cofactor + RESID-alternate + + + + DiffAvg + 937.42 + + + + DiffFormula + C 7 Fe 8 H 6 N 0 O 7 S 9 + + + + DiffMono + 937.240588 + + + + FormalCharge + 2- + + + + Formula + C 16 Fe 8 H 18 N 4 O 9 S 10 + + + + MassAvg + 1177.70 + + + + MassMono + 1177.308685 + + + + Origin + C, H + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00802 + L-histidino vanadium tetraoxide + + a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide + + 10543953 + PubMed + + + 16494433 + PubMed + + + 8552646 + PubMed + + + AA0395 + RESID + + + + (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium + RESID-alternate + + + 1'-vanadato-L-histidine + RESID-alternate + + + bromoperoxidase vanadium cofactor + RESID-alternate + + + chloroperoxidase vanadium cofactor + RESID-alternate + + + dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate + RESID-systematic + + + haloperoxidase vanadium cofactor + RESID-alternate + + + histidine-1-vanadate + RESID-alternate + + + histidine-N(epsilon)-vanadate + RESID-alternate + + + histidine-N1'-vanadate + RESID-alternate + + + L-histidino vanadium tetraoxide + RESID-name + + + N(tau)-vanadatohistidine + RESID-alternate + + + NtauH2VO4His + PSI-MOD-label + + + tele-vanadatohistidine + RESID-alternate + + + + DiffAvg + 116.95 + + + + DiffFormula + C 0 H 2 N 0 O 4 V 1 + + + + DiffMono + 116.939268 + + + + Formula + C 6 H 9 N 3 O 5 V 1 + + + + MassAvg + 254.10 + + + + MassMono + 253.998180 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00772 + MOD:00909 + PSI-MOD + + + MOD:00803 + 3-(S-L-cysteinyl)-L-tyrosine + + A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine. + + 15342250 + PubMed + + + AA0396 + RESID + + + Cross-link 2. + + (2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid + RESID-systematic + + + 2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid + RESID-alternate + + + 3-(L-cystein-S-yl)-L-tyrosine + RESID-name + + + CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr) + UniProt-feature + + + S-(tyros-3'-yl)cysteine + RESID-alternate + + + XLNKSCys3Tyr + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 12 H 12 N 2 O 3 S 1 + + + + MassAvg + 264.30 + + + + MassMono + 264.056863 + + + + Origin + C, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00919 + MOD:01993 + PSI-MOD + + + MOD:00804 + O-glucosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine. + + 10734111 + PubMed + + + 2105311 + PubMed + + + 2511201 + PubMed + + + AA0397 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (Glc) + UniProt-feature + + + CARBOHYD O-linked (Hex) + UniProt-feature + + + O-glucosyl-L-serine + RESID-name + + + O-glycosylserine + RESID-alternate + + + O3-glucosylserine + RESID-alternate + + + OGlcSer + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 9 H 15 N 1 O 7 + + + + MassAvg + 249.22 + + + + MassMono + 249.084852 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + MOD:00433 + MOD:00761 + PSI-MOD + + + MOD:00805 + O-(N-acetylamino)glucosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine. + + 3086323 + PubMed + + + 8404891 + PubMed + + + AA0398 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (GlcNAc) + UniProt-feature + + + CARBOHYD O-linked (HexNAc) + UniProt-feature + + + HexNAc + PSI-MS-label + + + O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine + RESID-alternate + + + O-(N-acetylamino)glucosyl-L-serine + RESID-name + + + O-(N-acetylglucosaminyl)serine + RESID-alternate + + + O-glycosylserine + RESID-alternate + + + O-seryl-beta-N-acetylglucosaminide + RESID-alternate + + + O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine + RESID-alternate + + + O3-(N-acetylglucosaminyl)serine + RESID-alternate + + + OGlcNAcSer + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 11 H 18 N 2 O 7 + + + + MassAvg + 290.27 + + + + MassMono + 290.111401 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00448 + MOD:01675 + PSI-MOD + + + MOD:00806 + O-(N-acetylamino)glucosyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine. + + 3086323 + PubMed + + + 8404891 + PubMed + + + AA0399 + RESID + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid + RESID-systematic + + + CARBOHYD O-linked (GlcNAc) + UniProt-feature + + + CARBOHYD O-linked (HexNAc) + UniProt-feature + + + HexNAc + PSI-MS-label + + + O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine + RESID-alternate + + + O-(N-acetylamino)glucosyl-L-threonine + RESID-name + + + O-(N-acetylglucosaminyl)-L-threonine + RESID-alternate + + + O-glycosylthreonine + RESID-alternate + + + O-threonyl-beta-N-acetylglucosaminide + RESID-alternate + + + O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine + RESID-alternate + + + O3-(N-acetylglucosaminyl)threonine + RESID-alternate + + + OGlcNAcThr + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 12 H 20 N 2 O 7 + + + + MassAvg + 304.30 + + + + MassMono + 304.127051 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00448 + MOD:01676 + PSI-MOD + + + MOD:00807 + pyruvic acid (Ser) + + A protein modification that effectively converts an L-serine residue to pyruvic acid. + + 23 + DeltaMass + + + 10085076 + PubMed + + + 3042771 + PubMed + + + 8464063 + PubMed + + + AA0127#SER + RESID + + + 385#S + UniMod + + + DeltaMass gives mass 70 and difference mass -16 with no formula + PSI-MOD-slim + + 2-oxopropanoic acid + RESID-systematic + + + MOD_RES Pyruvic acid (Ser) + UniProt-feature + + + Pyruvate + DeltaMass-label + + + pyruvic acid + RESID-name + + + Pyruvoyl- (Serine) + DeltaMass-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 3 H 3 O 2 + + + + MassAvg + 71.06 + + + + MassMono + 71.013304 + + + + Origin + S + + + + Source + natural + + + + TermSpec + N-term + + MOD:00916 + MOD:01154 + MOD:01160 + PSI-MOD + + + MOD:00808 + O-galactosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-galactosylserine. + + 666730 + PubMed + + + AA0400 + RESID + + + + (2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (Gal) + UniProt-feature + + + CARBOHYD O-linked (Hex) + UniProt-feature + + + O-galactosyl-L-serine + RESID-name + + + O-glycosylserine + RESID-alternate + + + O3-galactosylserine + RESID-alternate + + + OGalSer + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 9 H 15 N 1 O 7 + + + + MassAvg + 249.22 + + + + MassMono + 249.084852 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + MOD:00476 + MOD:00761 + PSI-MOD + + + MOD:00809 + O-galactosyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine. + + 2673008 + PubMed + + + AA0401 + RESID + + + + (2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid + RESID-systematic + + + CARBOHYD O-linked (Gal) + UniProt-feature + + + CARBOHYD O-linked (Hex) + UniProt-feature + + + O-galactosyl-L-threonine + RESID-name + + + O-glycosylthreonine + RESID-alternate + + + O3-galactosylthreonine + RESID-alternate + + + OGalThr + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 10 H 17 N 1 O 7 + + + + MassAvg + 263.25 + + + + MassMono + 263.100502 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00476 + MOD:00761 + MOD:01348 + PSI-MOD + + + MOD:00810 + O-mannosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-mannosylserine. + + 391559 + PubMed + + + AA0402 + RESID + + + + (2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (Hex) + UniProt-feature + + + CARBOHYD O-linked (Man) + UniProt-feature + + + O-glycosylserine + RESID-alternate + + + O-mannopyranosylserine + RESID-alternate + + + O-mannosyl-L-serine + RESID-name + + + O3-mannosylserine + RESID-alternate + + + OManSer + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 9 H 15 N 1 O 7 + + + + MassAvg + 249.22 + + + + MassMono + 249.084852 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + MOD:00595 + MOD:00761 + PSI-MOD + + + MOD:00811 + O-mannosyl-L-threonine + + a protein modification that effectively forms a O3-mannosylthreonine + + 391559 + PubMed + + + AA0403 + RESID + + + + (2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid + RESID-systematic + + + CARBOHYD O-linked (Hex) + UniProt-feature + + + CARBOHYD O-linked (Man) + UniProt-feature + + + O-glycosylthreonine + RESID-alternate + + + O-mannosyl-L-threonine + RESID-name + + + O3-mannosylthreonine + RESID-alternate + + + OManThr + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 10 H 17 N 1 O 7 + + + + MassAvg + 263.25 + + + + MassMono + 263.100502 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00595 + MOD:00761 + MOD:01348 + PSI-MOD + + + MOD:00812 + O-fucosyl-L-serine + + A protein modification that effectively converts an L-serine residue to an O-fucosylserine. + + 10734111 + PubMed + + + 11067851 + PubMed + + + 11344537 + PubMed + + + 12096136 + PubMed + + + 1517205 + PubMed + + + 15189151 + PubMed + + + 1904059 + PubMed + + + 3311742 + PubMed + + + 3578767 + PubMed + + + AA0404 + RESID + + + 295#S + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid + RESID-systematic + + + CARBOHYD O-linked (dHex) + UniProt-feature + + + CARBOHYD O-linked (Fuc) + UniProt-feature + + + dHex + PSI-MS-label + + + Fucose + UniMod-description + + + O-fucosyl-L-serine + RESID-name + + + O-glycosylserine + RESID-alternate + + + O3-fucosylserine + RESID-alternate + + + OFucSer + PSI-MOD-label + + + + DiffAvg + 146.14 + + + + DiffFormula + C 6 H 10 N 0 O 4 + + + + DiffMono + 146.057909 + + + + Formula + C 9 H 15 N 1 O 6 + + + + MassAvg + 233.22 + + + + MassMono + 233.089937 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + MOD:00614 + PSI-MOD + + + MOD:00813 + O-fucosyl-L-threonine + + A protein modification that effectively converts an threonine residue to an O-fucosylthreonine. + + 11344537 + PubMed + + + 11857757 + PubMed + + + 15189151 + PubMed + + + 1740125 + PubMed + + + 1900431 + PubMed + + + AA0405 + RESID + + + 295#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid + RESID-systematic + + + CARBOHYD O-linked (dHex) + UniProt-feature + + + CARBOHYD O-linked (Fuc) + UniProt-feature + + + dHex + PSI-MS-label + + + Fucose + UniMod-description + + + O-fucosyl-L-threonine + RESID-name + + + O-glycosylthreonine + RESID-alternate + + + O3-fucosylthreonine + RESID-alternate + + + OFucThr + PSI-MOD-label + + + + DiffAvg + 146.14 + + + + DiffFormula + C 6 H 10 N 0 O 4 + + + + DiffMono + 146.057909 + + + + Formula + C 10 H 17 N 1 O 6 + + + + MassAvg + 247.25 + + + + MassMono + 247.105587 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00005 + MOD:00614 + PSI-MOD + + + MOD:00814 + O-xylosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-xylosylserine. + + 8747463 + PubMed + + + AA0406 + RESID + + + One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG]. + + (2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid + RESID-systematic + + + O-(beta-D-xylopyranosyl)-L-serine + RESID-alternate + + + O-glycosylserine + RESID-alternate + + + O-xylosyl-L-serine + RESID-name + + + O3-xylosylserine + RESID-alternate + + + OXylSer + PSI-MOD-label + + + + DiffAvg + 132.12 + + + + DiffFormula + C 5 H 8 N 0 O 4 + + + + DiffMono + 132.042259 + + + + Formula + C 8 H 13 N 1 O 6 + + + + MassAvg + 219.19 + + + + MassMono + 219.074287 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:00815 + molybdopterin + + OBSOLETE because redundant with MOD:00151. Remap to MOD:00151. + + 14527393 + PubMed + + + 7878465 + PubMed + + + 9428520 + PubMed + + + + + DiffAvg + 520.27 + + + + DiffFormula + C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 + + + + DiffMono + 521.884074 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00816 + S-stearoyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine. + + 0 + DeltaMass + + + 2371783 + PubMed + + + 3143715 + PubMed + + + 8761467 + PubMed + + + AA0407 + RESID + + + From DeltaMass: Average Mass: 266 + PSI-MOD-slim + + (R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(octadecanoylthio)propanoic acid + RESID-alternate + + + cysteine octadecanoate thioester + RESID-alternate + + + cysteine stearate thioester + RESID-alternate + + + LIPID S-stearoyl cysteine + UniProt-feature + + + S-stearoyl-L-cysteine + RESID-name + + + SSteCys + PSI-MOD-label + + + Stearoylation + DeltaMass-label + + + + DiffAvg + 266.47 + + + + DiffFormula + C 18 H 34 N 0 O 1 S 0 + + + + DiffMono + 266.260966 + + + + Formula + C 21 H 39 N 1 O 2 S 1 + + + + MassAvg + 369.61 + + + + MassMono + 369.270150 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00672 + MOD:00905 + MOD:01155 + PSI-MOD + + + MOD:00817 + 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. + + 35304 + ChEBI + + + 16407988 + PubMed + + + 8168130 + PubMed + + + AA0408 + RESID + + + + (2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid + RESID-systematic + + + (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan + RESID-alternate + + + 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan + RESID-name + + + 3'Ger2'N2cycTrp + PSI-MOD-label + + + LIPID 3'-geranyl-2',N2-cyclotryptophan + UniProt-feature + + + + DiffAvg + 136.24 + + + + DiffFormula + C 10 H 16 N 0 O 0 + + + + DiffMono + 136.125201 + + + + Formula + C 21 H 26 N 2 O 1 + + + + MassAvg + 322.45 + + + + MassMono + 322.204513 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00601 + MOD:01115 + PSI-MOD + + + MOD:00818 + glycosylphosphatidylinositolated residue + + A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated. + + 12643538 + PubMed + + + 394#C-term + UniMod + + + + glycosylphosphatidylinositol + UniMod-description + + + GPIanchor + UniMod-interim + + + GPIRes + PSI-MOD-label + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + C-term + + MOD:00764 + MOD:00861 + MOD:01155 + PSI-MOD + + + MOD:00819 + L-2-aminobutanoic acid (Glu) + + A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid. + + 35619 + ChEBI + + + 0 + DeltaMass + + + 11740505 + PubMed + + + AA0409 + RESID + + + + (S)-2-aminobutanoic acid + RESID-systematic + + + Abu + DeltaMass-label + + + Abu + PSI-MOD-label + + + alpha-amino-n-butyric acid + PSI-MOD-alternate + + + alpha-aminobutyric acid + PSI-MOD-alternate + + + butyrine + PSI-MOD-alternate + + + dCbxGlu + PSI-MOD-alternate + + + L-2-amino-n-butyric acid + RESID-alternate + + + L-2-aminobutanoic acid + RESID-name + + + L-2-aminobutyric acid + RESID-alternate + + + L-alpha-amino-n-butyric acid + RESID-alternate + + + L-alpha-aminobutyric acid + RESID-alternate + + + L-butyrine + RESID-alternate + + + + DiffAvg + -44.01 + + + + DiffFormula + C -1 H 0 N 0 O -2 + + + + DiffMono + -43.989829 + + + + Formula + C 4 H 7 N 1 O 1 + + + + MassAvg + 85.11 + + + + MassMono + 85.052764 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + PSI-MOD + + + MOD:00820 + 2-imino-alanine 5-imidazolinone glycine + + A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine. + + 16627946 + PubMed + + + AA0410 + RESID + + + Cross-link 2; carboxamidine. + + (2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid + RESID-systematic + + + 2,N-didehydroalanyl-5-imidazolinone glycine + RESID-alternate + + + 2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one + RESID-alternate + + + 2-imino-alanine 5-imidazolinone glycine + RESID-name + + + 2-imino-alanyl-5-imidazolinone glycine + RESID-alternate + + + [2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid + RESID-alternate + + + alanyl-5-imidazolinone glycine + RESID-alternate + + + para-hydroxybenzylidene-imidazolidinone chromophore + RESID-alternate + + + red fluorescent protein zRFP574 chromophore + RESID-alternate + + + + DiffAvg + -64.04 + + + + DiffFormula + C -1 H -4 N 0 O -3 + + + + DiffMono + -64.016044 + + + + Formula + C 5 H 4 N 2 O 1 + + + + MassAvg + 108.10 + + + + MassMono + 108.032363 + + + + Origin + D, G + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:00908 + MOD:01882 + PSI-MOD + + + MOD:00821 + S-(L-alanyl)-L-cysteine + + A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine. + + 11807079 + PubMed + + + AA0411 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid + RESID-systematic + + + alanine cysteine thioester + RESID-alternate + + + CROSSLNK Alanyl cysteine thioester (Cys-Ala) + UniProt-feature + + + S-(2-aminopropanoyl)cysteine + RESID-alternate + + + S-(L-alanyl)-L-cysteine + RESID-name + + + XLNK1AlaSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 9 N 2 O 2 S 1 + + + + MassAvg + 173.21 + + + + MassMono + 173.038474 + + + + Origin + A, C + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00395 + MOD:00901 + MOD:00954 + PSI-MOD + + + MOD:00822 + S-(L-leucyl)-L-cysteine + + A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine. + + 12591958 + PubMed + + + AA0412 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid + RESID-systematic + + + CROSSLNK Leucyl cysteine thioester (Cys-Leu) + UniProt-feature + + + leucine cysteine thioester + RESID-alternate + + + S-(2-amino-4-methylpentanoyl)cysteine + RESID-alternate + + + S-(L-leucyl)-L-cysteine + RESID-name + + + XLNK1LeuSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 9 H 15 N 2 O 2 S 1 + + + + MassAvg + 215.29 + + + + MassMono + 215.085424 + + + + Origin + C, L + + + + Source + natural + + + + TermSpec + C-term + + MOD:00395 + MOD:00911 + MOD:00954 + PSI-MOD + + + MOD:00823 + S-(L-methionyl)-L-cysteine + + A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine. + + 12146974 + PubMed + + + AA0413 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid + RESID-systematic + + + CROSSLNK Methionyl cysteine thioester (Cys-Met) + UniProt-feature + + + methionine cysteine thioester + RESID-alternate + + + S-(2-amino-4-methylthiobutanoyl)cysteine + RESID-alternate + + + S-(L-methionyl)-L-cysteine + RESID-name + + + XLNK1MetSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 8 H 13 N 2 O 2 S 2 + + + + MassAvg + 233.32 + + + + MassMono + 233.041845 + + + + Origin + C, M + + + + Source + natural + + + + TermSpec + C-term + + MOD:00395 + MOD:00913 + MOD:00954 + PSI-MOD + + + MOD:00824 + dehydroalanine (Tyr) + + A protein modification that effectively converts an L-tyrosine residue to dehydroalanine. + + 10220322 + PubMed + + + 1547888 + PubMed + + + 1815586 + PubMed + + + 2914619 + PubMed + + + 6838602 + PubMed + + + 7947813 + PubMed + + + 8239649 + PubMed + + + AA0181#TYR + RESID + + + 400 + UniMod + + + incidental to RESID:AA0178 + + 2,3-didehydroalanine + RESID-alternate + + + 2-aminoacrylic acid + RESID-alternate + + + 2-aminopropenoic acid + RESID-systematic + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + anhydroserine + RESID-alternate + + + dehydroalanine + RESID-name + + + Dha + RESID-alternate + + + dHAla(Tyr) + PSI-MOD-label + + + + DiffAvg + -94.11 + + + + DiffFormula + C -6 H -6 N 0 O -1 + + + + DiffMono + -94.041865 + + + + Formula + C 3 H 3 N 1 O 1 + + + + MassAvg + 69.06 + + + + MassMono + 69.021464 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00919 + MOD:01168 + PSI-MOD + + + MOD:00825 + S-(L-phenylalanyl)-L-cysteine + + A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine. + + 12591958 + PubMed + + + AA0414 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid + RESID-systematic + + + CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe) + UniProt-feature + + + phenylalanine cysteine thioester + RESID-alternate + + + S-(2-amino-3-phenylpropanoyl)cysteine + RESID-alternate + + + S-(L-phenylalanyl)-L-cysteine + RESID-name + + + XLNK1PheSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 12 H 13 N 2 O 2 S 1 + + + + MassAvg + 249.31 + + + + MassMono + 249.069774 + + + + Origin + C, F + + + + Source + natural + + + + TermSpec + C-term + + MOD:00395 + MOD:00914 + MOD:00954 + PSI-MOD + + + MOD:00826 + S-(L-threonyl)-L-cysteine + + A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine. + + 15268951 + PubMed + + + AA0415 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid + RESID-systematic + + + CROSSLNK Threonyl cysteine thioester (Cys-Thr) + UniProt-feature + + + S-(2-amino-3-hydroxybutanoyl)cysteine + RESID-alternate + + + S-(L-threonyl)-L-cysteine + RESID-name + + + threonine cysteine thioester + RESID-alternate + + + XLNK1ThrSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 11 N 2 O 3 S 1 + + + + MassAvg + 203.24 + + + + MassMono + 203.049038 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00395 + MOD:00917 + MOD:00954 + PSI-MOD + + + MOD:00827 + S-(L-tyrosyl)-L-cysteine + + A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine. + + 11807079 + PubMed + + + AA0416 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid + RESID-systematic + + + CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr) + UniProt-feature + + + S-(L-tyrosyl)-L-cysteine + RESID-name + + + S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine + RESID-alternate + + + tyrosine cysteine thioester + RESID-alternate + + + XLNK1TyrSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 12 H 13 N 2 O 3 S 1 + + + + MassAvg + 265.31 + + + + MassMono + 265.064688 + + + + Origin + C, Y + + + + Source + natural + + + + TermSpec + C-term + + MOD:00395 + MOD:00919 + MOD:00954 + PSI-MOD + + + MOD:00828 + S-(L-tryptophanyl)-L-cysteine + + A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine. + + 16030216 + PubMed + + + AA0417 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid + RESID-systematic + + + CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp) + UniProt-feature + + + S-(L-tryptophanyl)-L-cysteine + RESID-name + + + S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine + RESID-alternate + + + tryptophan cysteine thioester + RESID-alternate + + + XLNK1TrpSCys + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 14 H 14 N 3 O 2 S 1 + + + + MassAvg + 288.35 + + + + MassMono + 288.080673 + + + + Origin + C, W + + + + Source + natural + + + + TermSpec + C-term + + MOD:00395 + MOD:00918 + MOD:00954 + PSI-MOD + + + MOD:00829 + O-(L-phenylalanyl)-L-serine + + A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine. + + 12591958 + PubMed + + + AA0418 + RESID + + + Cross-link 2. + + (2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid + RESID-systematic + + + CROSSLNK Phenylalanyl serine ester (Ser-Phe) + UniProt-feature + + + O-(2-amino-3-phenylpropanoyl)serine + RESID-alternate + + + O-(L-phenylalanyl)-L-serine + RESID-name + + + phenylalanine serine ester + RESID-alternate + + + XLNK1PheOSer + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 12 H 13 N 2 O 3 + + + + MassAvg + 233.25 + + + + MassMono + 233.092617 + + + + Origin + F, S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00885 + MOD:00914 + MOD:00916 + MOD:00954 + PSI-MOD + + + MOD:00830 + N-methyl-L-proline + + A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline. + + 3127388 + PubMed + + + AA0419 + RESID + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + PSI-MOD-slim + + (S)-1-methylpyrrolidine-2-carboxylic acid + RESID-systematic + + + 1-methylpyrrolidine-2-carboxylic acid + RESID-alternate + + + hygric acid + RESID-alternate + + + MOD_RES N-methylproline + UniProt-feature + + + N-methyl-L-proline + RESID-name + + + N-methylated L-proline + PSI-MOD-alternate + + + NMePro + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 10 N 1 O 1 + + + + MassAvg + 112.15 + + + + MassMono + 112.076239 + + + + Origin + P + + + + Source + natural + + + + TermSpec + N-term + + MOD:01417 + MOD:01462 + MOD:01680 + PSI-MOD + + + MOD:00831 + N4-(N-acetylamino)glucosyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine. + + 111247 + PubMed + + + 1694179 + PubMed + + + 5490222 + PubMed + + + AA0151#var + RESID + + + PSI-MOD-slim + + HexNAc + PSI-MS-label + + + N4GlcNAcAsn + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 12 H 19 N 3 O 7 + + + + MassAvg + 317.30 + + + + MassMono + 317.122300 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00448 + MOD:01674 + PSI-MOD + + + MOD:00832 + N4-(N-acetylamino)galactosyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine. + + 8262914 + PubMed + + + AA0420 + RESID + + + + (2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid + RESID-systematic + + + HexNAc + PSI-MS-label + + + N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine + RESID-alternate + + + N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine + RESID-alternate + + + N4-(N-acetylamino)galactosyl-L-asparagine + RESID-name + + + N4-(N-acetylgalactosaminyl)asparagine + RESID-alternate + + + N4-asparagine-beta-N-acetylgalactosaminide + RESID-alternate + + + N4-glycosyl-L-asparagine + RESID-alternate + + + N4-glycosylasparagine + RESID-alternate + + + N4GalNAcAsn + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 12 H 19 N 3 O 7 + + + + MassAvg + 317.30 + + + + MassMono + 317.122300 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00563 + MOD:01674 + PSI-MOD + + + MOD:00833 + N4-glucosyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine. + + 1569073 + PubMed + + + 3410849 + PubMed + + + AA0421 + RESID + + + + (2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid + RESID-systematic + + + CARBOHYD N-linked (Glc) + UniProt-feature + + + N4-(D-glucopyranosyl)-L-asparagine + RESID-alternate + + + N4-asparagine-glucoside + RESID-alternate + + + N4-glucosyl-L-asparagine + RESID-name + + + N4-glucosylasparagine + RESID-alternate + + + N4-glycosyl-L-asparagine + RESID-alternate + + + N4-glycosylasparagine + RESID-alternate + + + N4GlcAsn + PSI-MOD-label + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 10 H 16 N 2 O 7 + + + + MassAvg + 276.25 + + + + MassMono + 276.095751 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00433 + MOD:00761 + MOD:01346 + PSI-MOD + + + MOD:00834 + O-(N-acetylamino)fucosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine. + + 11342554 + PubMed + + + 12010970 + PubMed + + + AA0422 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid + RESID-systematic + + + O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine + RESID-alternate + + + O-(N-acetylamino)fucosyl-L-serine + RESID-name + + + O-(N-acetylfucosaminyl)serine + RESID-alternate + + + O-seryl-beta-N-acetylfucosaminide + RESID-alternate + + + O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine + RESID-alternate + + + O3-(N-acetylfucosaminyl)serine + RESID-alternate + + + OFucNAcSer + PSI-MOD-label + + + + DiffAvg + 187.19 + + + + DiffFormula + C 8 H 13 N 1 O 4 + + + + DiffMono + 187.084458 + + + + Formula + C 11 H 18 N 2 O 6 + + + + MassAvg + 274.27 + + + + MassMono + 274.116486 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:00835 + L-3-oxoalanine (Ser) + + A protein modification that effectively converts an L-serine residue to L-oxoalanine. + + 349 + DeltaMass + + + 14563551 + PubMed + + + 7628016 + PubMed + + + 8681943 + PubMed + + + 9276974 + PubMed + + + 9478923 + PubMed + + + AA0185#SER + RESID + + + 401#S + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-oxopropanoic acid + RESID-systematic + + + 2-amino-3-oxopropionic acid + RESID-alternate + + + C(alpha)-formylglycine + RESID-misnomer + + + dehydrogenated serine residue + UniMod-description + + + Didehydro + PSI-MS-label + + + formylglycine + UniMod-alternate + + + formylglycine (from serine) + DeltaMass-label + + + L-3-oxoalanine + RESID-name + + + L-amino-malonic acid semialdehyde + RESID-alternate + + + L-aminomalonaldehydic acid + RESID-alternate + + + L-serinesemialdehyde + RESID-misnomer + + + MOD_RES 3-oxoalanine (Ser) + UniProt-feature + + + oxoalanine + UniMod-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 3 H 3 N 1 O 2 + + + + MassAvg + 85.06 + + + + MassMono + 85.016378 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01169 + MOD:01888 + PSI-MOD + + + MOD:00836 + deuterium disubstituted residue + + A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + D(H)2Res + PSI-MOD-label + + MOD:00786 + PSI-MOD + + + MOD:00837 + deuterium tetrasubstituted residue + + A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms. + + 18688235 + PubMed + + + + D(H)4Res + PSI-MOD-label + + MOD:00786 + PSI-MOD + + + MOD:00838 + 3x(2)H labeled L-leucine + + A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine. + + 262#L + UniMod + + + + D(H)3Leu + PSI-MOD-label + + + Label:2H(3) + PSI-MS-label + + + Trideuteration + UniMod-description + + + + DiffAvg + 3.02 + + + + DiffFormula + (1)H -3 (2)H 3 + + + + DiffMono + 3.018830 + + + + Formula + C 6 (1)H 8 (2)H 3 N 1 O 1 + + + + MassAvg + 116.10 + + + + MassMono + 116.102894 + + + + Origin + L + + + + Source + artifact + + + + TermSpec + none + + MOD:00585 + MOD:00911 + PSI-MOD + + + MOD:00839 + (2)H deuterium labeled residue + + A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00702 + PSI-MOD + + + MOD:00840 + isocyanate reagent derivatized residue + + A protein modification produced by formation of an adduct with an isocyanate compound. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00848 + PSI-MOD + + + MOD:00841 + isothiocyanate reagent derivatized residue + + A protein modification produced by formation of an adduct with an isothiocyanate compound. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00848 + PSI-MOD + + + MOD:00842 + (13)C labeled residue + + A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00702 + PSI-MOD + + + MOD:00843 + (15)N labeled residue + + A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00702 + PSI-MOD + + + MOD:00844 + (18)O labeled residue + + A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00702 + PSI-MOD + + + MOD:00845 + (18)O substituted residue + + A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00844 + PSI-MOD + + + MOD:00846 + levuglandinyl (prostaglandin H2) adduct + + stub + + 18688235 + PubMed + + + MOD:00848 + PSI-MOD + + + MOD:00847 + (18)O disubstituted residue + + A protein modification that effectively substitutes two (18)O atom for two (16)O atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00845 + PSI-MOD + + + MOD:00848 + reagent derivatized residue + + A protein modification that is produced by formation of an adduct with a particular compound used as a reagent. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01156 + PSI-MOD + + + MOD:00849 + potassium containing modified residue + + A protein modification that effectively substitutes a potassium atom for a hydrogen atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + KRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:00850 + unnatural residue + + A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01157 + PSI-MOD + + + MOD:00851 + (18)O labeled deamidated residue + + A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00400 + MOD:00844 + PSI-MOD + + + MOD:00852 + 1x(18)O labeled deamidated residue + + A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O. + + 8382902 + PubMed + + + 366 + UniMod + + + PSI-MOD-slim + + + DiffAvg + 2.99 + + + + DiffFormula + H -1 N -1 (18)O 1 + + + + DiffMono + 2.988262 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00851 + PSI-MOD + + + MOD:00853 + 2x(18)O labeled deamidated residue + + A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O. + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 4.99 + + + + DiffFormula + H -1 N -1 (16)O -1 (18)O 2 + + + + DiffMono + 4.992508 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00851 + PSI-MOD + + + MOD:00854 + protonated L-lysine (L-lysinium) residue + + A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine). + + 18688235 + PubMed + + + Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative. + PSI-MOD-slim + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 13 N 2 O 1 + + + + MassAvg + 129.18 + + + + MassMono + 129.102239 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01699 + PSI-MOD + + + MOD:00855 + N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue) + + A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine. + + 0 + DeltaMass + + + 12590383 + PubMed + + + 3145979 + PubMed + + + 4304194 + PubMed + + + 6778808 + PubMed + + + 7093227 + PubMed + + + 8453381 + PubMed + + + 37#K + UniMod + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation. + PSI-MOD-slim + + N6Me3Lys + PSI-MOD-label + + + trimethylk + OMSSA-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 + + + + DiffMono + 42.046402 + + + + FormalCharge + 1+ + + + + Formula + C 9 H 19 N 2 O 1 + + + + MassAvg + 171.26 + + + + MassMono + 171.149190 + + + + Origin + MOD:00854 + + + + Source + natural + + + + TermSpec + none + + MOD:00430 + + derives_from + MOD:008540 + + PSI-MOD + + + MOD:00856 + protonated L-alanine (L-alaninium) residue + + A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine). + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + C 3 H 7 N 1 O 1 + + + + MassAvg + 73.09 + + + + MassMono + 73.052215 + + + + Origin + A + + + + Source + natural + + + + TermSpec + N-term + + MOD:00901 + MOD:01700 + PSI-MOD + + + MOD:00857 + N,N,N-trimethyl-L-alanine (from L-alaninium) + + A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine. + + 12590383 + PubMed + + + 332162 + PubMed + + + 3979397 + PubMed + + + 6778808 + PubMed + + + 7715456 + PubMed + + + 37#A + UniMod + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation. + PSI-MOD-slim + + N2Me3Ala + PSI-MOD-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 + + + + DiffMono + 42.046402 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 13 N 1 O 1 + + + + MassAvg + 115.18 + + + + MassMono + 115.099165 + + + + Origin + MOD:00856 + + + + Source + natural + + + + TermSpec + N-term + + MOD:01687 + + derives_from + MOD:008560 + + PSI-MOD + + + MOD:00858 + D-alanine (Ser) + + A protein modification that effectively converts an L-serine residue to D-alanine. + + 7961627 + PubMed + + + AA0191#SER + RESID + + + + (R)-2-aminopropanoic acid + RESID-systematic + + + D-Ala(Ser) + PSI-MOD-label + + + D-alanine + RESID-name + + + MOD_RES D-alanine (Ser) + UniProt-feature + + + + DiffAvg + -16.00 + + + + DiffFormula + C 0 H 0 N 0 O -1 + + + + DiffMono + -15.994915 + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00862 + MOD:00916 + MOD:01161 + PSI-MOD + + + MOD:00859 + modified residue that can arise from different natural residues + + A protein modification that can be derived from different natural residues by different chemical processes. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01157 + PSI-MOD + + + MOD:00860 + sulfur containing modified residue + + A protein modification that produces an amino acid residue containing an exogenous sulfur atom. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01156 + PSI-MOD + + + MOD:00861 + phosphorus containing modified residue + + A protein modification that produces an amino acid residue containing a phosphorus atom. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01156 + PSI-MOD + + + MOD:00862 + D-alanine + + A protein modification that effectively converts a source amino acid residue to D-alanine. + + 29949 + ChEBI + + + 7287302 + PubMed + + + 7961627 + PubMed + + + AA0191 + RESID + + + + (R)-2-aminopropanoic acid + RESID-systematic + + + D-alanine + RESID-name + + + MOD_RES D-alanine (Ala) + UniProt-feature + + + MOD_RES D-alanine (Ser) + UniProt-feature + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00859 + PSI-MOD + + + MOD:00863 + D-allo-threonine + + A protein modification that effectively converts an L-threonine residue to D-allo-threonine. + + 32826 + ChEBI + + + 18025465 + PubMed + + + 6893271 + PubMed + + + AA0199 + RESID + + + + (2R,3R)-2-amino-3-hydroxybutanoic acid + RESID-systematic + + + D-Thr + PSI-MOD-label + + + D-threonine + RESID-name + + + MOD_RES D-threonine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 4 H 7 N 1 O 2 + + + + MassAvg + 101.10 + + + + MassMono + 101.047678 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00917 + PSI-MOD + + + MOD:00864 + tris-L-cysteinyl L-histidino diiron disulfide + + A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide. + + 17766439 + PubMed + + + 17766440 + PubMed + + + AA0438 + RESID + + + Cross-link 4. + + CDGSH domain iron-sulfur cluster + RESID-alternate + + + di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron) + RESID-systematic + + + METAL Iron-sulfur (2Fe-2S) + UniProt-feature + + + METAL Iron-sulfur (2Fe-2S); via pros nitrogen + UniProt-feature + + + tris-L-cysteinyl L-histidino diiron disulfide + RESID-name + + + + DiffAvg + 171.78 + + + + DiffFormula + C 0 Fe 2 H -4 N 0 O 0 S 2 + + + + DiffMono + 171.783814 + + + + FormalCharge + 2- + + + + Formula + C 15 Fe 2 H 18 N 6 O 4 S 5 + + + + MassAvg + 618.34 + + + + MassMono + 617.870280 + + + + Origin + C, C, C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00909 + PSI-MOD + + + MOD:00865 + N-aspartyl-glycosylsphingolipidinositolethanolamine + + A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine. + + AA0439 + RESID + + + + GSIAsp + PSI-MOD-label + + + LIPID GPI-like-anchor amidated aspartate + UniProt-feature + + + N-aspartyl-glycosylsphingolipidinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 6 H 12 N 2 O 7 P 1 + + + + MassAvg + 255.14 + + + + MassMono + 255.038212 + + + + Origin + D + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00466 + MOD:00904 + PSI-MOD + + + MOD:00866 + dihydroxylated proline + + A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline. + + 18688235 + PubMed + + + + Hy2Pro + PSI-MOD-label + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00428 + MOD:00678 + PSI-MOD + + + MOD:00867 + L-cysteinyl-L-selenocysteine (Cys-Cys) + + A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine. + + 10801974 + PubMed + + + 12911312 + PubMed + + + 17177418 + PubMed + + + AA0358#CYS + RESID + + + Cross-link 2. + + (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid + RESID-systematic + + + CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) + UniProt-feature + + + CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) + UniProt-feature + + + L-cysteinyl-L-selenocysteine + RESID-name + + + + DiffAvg + 44.90 + + + + DiffFormula + C 0 H -2 N 0 O 0 S -1 Se 1 + + + + DiffMono + 45.928800 + + + + Formula + C 6 H 8 N 2 O 2 S 1 Se 1 + + + + MassAvg + 251.17 + + + + MassMono + 251.947170 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00007 + MOD:01627 + PSI-MOD + + + MOD:00868 + natural, non-standard encoded residue + + A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine. + + 18688235 + PubMed + + + These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications. + PSI-MOD-slim + + + Origin + X + + + + Source + natural + + MOD:00009 + PSI-MOD + + + MOD:00869 + L-alanine residue (Asp) + + A protein modification that effectively converts an L-aspartic acid residue to L-alanine. + + 17138938 + PubMed + + + AA0001#ASP + RESID + + + This has been reported to occur by a natural process of beta-decarboxylation. + + (2S)-2-aminopropanoic acid + RESID-systematic + + + 2-aminopropionic acid + RESID-alternate + + + 2-azanylpropanoic acid + RESID-alternate + + + alpha-alanine + RESID-alternate + + + alpha-aminopropionic acid + RESID-alternate + + + Asp(Ala) + PSI-MOD-label + + + L-alanine + RESID-name + + + MOD_RES Beta-decarboxylated aspartate + UniProt-feature + + + + DiffAvg + -44.01 + + + + DiffFormula + C -1 H 0 N 0 O -2 + + + + DiffMono + -43.989829 + + + + Formula + C 3 H 5 N 1 O 1 + + + + MassAvg + 71.08 + + + + MassMono + 71.037114 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00010 + MOD:00904 + PSI-MOD + + + MOD:00870 + phenyl isocyanate derivatized residue + + A protein modification produced by formation of an adduct with phenyl isocyanate. + + 411 + UniMod + + + From UniMod with no citation. + PSI-MOD-slim + + phenyl isocyanate + UniMod-description + + + Phenylisocyanate + PSI-MS-label + + + + DiffAvg + 119.12 + + + + DiffFormula + C 7 H 5 N 1 O 1 + + + + DiffMono + 119.037114 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00840 + PSI-MOD + + + MOD:00871 + (2)H5-phenyl isocyanate derivatized residue + + A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate. + + 412 + UniMod + + + From UniMod with no citation. + PSI-MOD-slim + + d5-phenyl isocyanate + UniMod-description + + + Phenylisocyanate:2H(5) + PSI-MS-label + + + + DiffAvg + 124.07 + + + + DiffFormula + C 7 (2)H 5 N 1 O 1 + + + + DiffMono + 124.068498 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00870 + MOD:01431 + PSI-MOD + + + MOD:00872 + L-isoglutamyl monoglutamic acid + + OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970. + + 10747868 + PubMed + + + 15525938 + PubMed + + + 1680872 + PubMed + + + AA0202#var + RESID + + + 450 + UniMod + + + + Glu + UniMod-interim + + + monoglutamyl + UniMod-description + + + N alpha -(gamma-Glutamyl)-Glu + DeltaMass-label + + + + DiffAvg + 129.12 + + + + DiffFormula + C 5 H 7 N 1 O 3 + + + + DiffMono + 129.042593 + + + + Formula + C 10 H 14 N 2 O 6 + + + + MassAvg + 258.23 + + + + MassMono + 258.085186 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00873 + L-isoglutamyl diglutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid. + + 0 + DeltaMass + + + 10747868 + PubMed + + + 1680872 + PubMed + + + AA0202#var + RESID + + + 451 + UniMod + + + + diglutamyl + UniMod-description + + + GluGlu + UniMod-interim + + + + DiffAvg + 258.23 + + + + DiffFormula + C 10 H 14 N 2 O 6 + + + + DiffMono + 258.085186 + + + + Formula + C 15 H 21 N 3 O 9 + + + + MassAvg + 387.35 + + + + MassMono + 387.127779 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00207 + PSI-MOD + + + MOD:00874 + L-isoglutamyl triglutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid. + + 0 + DeltaMass + + + 10747868 + PubMed + + + 1680872 + PubMed + + + AA0202#var + RESID + + + 452 + UniMod + + + From DeltaMass: Average Mass: 388. + + GluGluGlu + UniMod-interim + + + N alpha -(gamma-Glutamyl)-Glu3 + DeltaMass-label + + + triglutamyl + UniMod-description + + + + DiffAvg + 387.35 + + + + DiffFormula + C 15 H 21 N 3 O 9 + + + + DiffMono + 387.127779 + + + + Formula + C 20 H 28 N 4 O 12 + + + + MassAvg + 516.46 + + + + MassMono + 516.170372 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00207 + PSI-MOD + + + MOD:00875 + L-isoglutamyl tetraglutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid. + + 10747868 + PubMed + + + 1680872 + PubMed + + + AA0202#var + RESID + + + 453 + UniMod + + + + GluGluGluGlu + UniMod-interim + + + tetraglutamyl + UniMod-description + + + + DiffAvg + 516.46 + + + + DiffFormula + C 20 H 28 N 4 O 12 + + + + DiffMono + 516.170372 + + + + Formula + C 25 H 35 N 5 O 15 + + + + MassAvg + 645.57 + + + + MassMono + 645.212965 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00207 + PSI-MOD + + + MOD:00876 + hexosaminylated residue + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond. + + 454 + UniMod + + + + HexN + PSI-MS-label + + + Hexosamine + UniMod-description + + + Hexosamines (GalN, GlcN) + DeltaMass-label + + + + DiffAvg + 161.16 + + + + DiffFormula + C 6 H 11 N 1 O 4 + + + + DiffMono + 161.068808 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00877 + imidoester crosslink dimethyl pimelimidate singly attached + + dimethyl pimelimidate modification from UniMod + + 455 + UniMod + + + + One end of crosslink attached, one end free + UniMod-description + + + Xlink:DMP-s + UniMod-interim + + + + DiffAvg + 154.21 + + + + DiffFormula + C 8 H 14 N 2 O 1 + + + + DiffMono + 154.110613 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00878 + imidoester crosslink dimethyl pimelimidate doubly attached + + dimethyl pimelimidate modification from UniMod - Mechanism of the reaction of imidoesters with amines + + 7171546 + PubMed + + + 456 + UniMod + + + + Both ends of crosslink attached to same peptide + UniMod-description + + + Xlink:DMP + UniMod-interim + + + + DiffAvg + 122.17 + + + + DiffFormula + C 7 H 10 N 2 + + + + DiffMono + 122.084398 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00879 + naphthalene-2,3-dicarboxaldehyde + + modification from UniMod + + 2081203 + PubMed + + + 457 + UniMod + + + + naphthalene-2,3-dicarboxaldehyde + UniMod-description + + + NDA + UniMod-interim + + + + DiffAvg + 175.19 + + + + DiffFormula + C 13 H 5 N 1 + + + + DiffMono + 175.042199 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00880 + 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue + + A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate. + + 15536630 + PubMed + + + 16526082 + PubMed + + + 464 + UniMod + + + + 4-sulfophenyl isothiocyanate (Heavy C13) + UniMod-description + + + SPITC:13C(6) + PSI-MS-label + + + + DiffAvg + 220.99 + + + + DiffFormula + (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 + + + + DiffMono + 220.991214 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00584 + MOD:01428 + PSI-MOD + + + MOD:00881 + N-reductive amination-D + + OBSOLETE because UniMod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D. + + 9252331 + PubMed + + + 465 + UniMod + + + + + DiffAvg + 32.06 + + + + DiffFormula + C 2 (2)H 4 + + + + DiffMono + 32.056407 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00882 + S-(2-aminoethyl)cysteine (Ser) + + A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine. + + 171 + DeltaMass + + + 12923550 + PubMed + + + 472#S + UniMod + + + From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. + + AEC-MAEC + UniMod-interim + + + Aminoethyl Cysteinyl (AECys) + DeltaMass-label + + + aminoethylcysteine + UniMod-description + + + + DiffAvg + 59.13 + + + + DiffFormula + C 2 H 5 N 1 O -1 S 1 + + + + DiffMono + 59.019356 + + + + Formula + C 5 H 10 N 2 O 1 S 1 + + + + MassAvg + 146.21 + + + + MassMono + 146.051384 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + PSI-MOD + + + MOD:00883 + C1-amidated residue + + A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group. + + 0 + DeltaMass + + + 2 + UniMod + + + The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG]. + PSI-MOD-slim + + alpha-amidated residue + PSI-MOD-alternate + + + Amidated + PSI-MS-label + + + Amidation + UniMod-description + + + Amide formation (C terminus) + DeltaMass-label + + + ctermamide + OMSSA-label + + + ResN + PSI-MOD-label + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + C-term + + MOD:00674 + PSI-MOD + + + MOD:00884 + S-aminoethylcysteine (Cys) + + A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine. + + 1175632 + PubMed + + + 18688235 + PubMed + + + This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine. + PSI-MOD-slim + + 4-thialysine + PSI-MOD-alternate + + + L-cysteine aziridine adduct + PSI-MOD-alternate + + + S-(2-aminoethyl)-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + 43.07 + + + + DiffFormula + C 2 H 5 N 1 O 0 S 0 + + + + DiffMono + 43.042199 + + + + Formula + C 5 H 10 N 2 O 1 S 1 + + + + MassAvg + 146.21 + + + + MassMono + 146.051384 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00885 + ester crosslinked residues + + A protein modification that crosslinks two residues by formation of an ester bond. + + 18688235 + PubMed + + + MOD:00033 + PSI-MOD + + + MOD:00886 + 6'-chloro-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan. + + 9033387 + PubMed + + + AA0180 + RESID + + + 936#W + UniMod + + + The UniMod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by UniMod:936 [JSG]. + + (2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 6'-chloro-L-tryptophan + RESID-name + + + 6'-ClTrp + PSI-MOD-label + + + MOD_RES 6'-chlorotryptophan + UniProt-feature + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 11 Cl 1 H 9 N 2 O 1 + + + + MassAvg + 220.66 + + + + MassMono + 220.040341 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:01913 + PSI-MOD + + + MOD:00887 + methylated aspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester. + + 18688235 + PubMed + + + MOD:00427 + MOD:00904 + PSI-MOD + + + MOD:00888 + protonated L-proline (L-prolinium) residue + + A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline). + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 9 N 1 O 1 + + + + MassAvg + 99.13 + + + + MassMono + 99.067865 + + + + Origin + P + + + + Source + natural + + + + TermSpec + N-term + + MOD:00915 + MOD:01700 + PSI-MOD + + + MOD:00889 + N,N-dimethyl-L-proline (from L-prolinium) + + A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline. + + 36#P + UniMod + + + PSI-MOD-slim + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.030752 + + + + FormalCharge + 1+ + + + + Formula + C 7 H 13 N 1 O 1 + + + + MassAvg + 127.19 + + + + MassMono + 127.099165 + + + + Origin + MOD:00888 + + + + Source + natural + + + + TermSpec + N-term + + MOD:00075 + + derives_from + MOD:008880 + + PSI-MOD + + + MOD:00890 + phosphorylated L-histidine + + A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine. + + 21#H + UniMod + + + PSI-MOD-slim + + mod192 + OMSSA-label + + + NPhosHis + PSI-MOD-label + + + Phospho + PSI-MS-label + + + phosphohistidine + PSI-MOD-alternate + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 6 H 8 N 3 O 4 P 1 + + + + MassAvg + 217.12 + + + + MassMono + 217.025242 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + MOD:01456 + PSI-MOD + + + MOD:00891 + D-serine + + A protein modification that effectively converts a source amino acid residue to D-serine. + + 29998 + ChEBI + + + 6893271 + PubMed + + + 7973665 + PubMed + + + AA0195 + RESID + + + + (R)-2-amino-3-hydroxypropanoic acid + RESID-systematic + + + D-Ser + PSI-MOD-label + + + D-serine + RESID-name + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 3 H 5 N 1 O 2 + + + + MassAvg + 87.08 + + + + MassMono + 87.032028 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00859 + PSI-MOD + + + MOD:00892 + D-serine (Cys) + + A protein modification that effectively converts an L-cysteine residue to D-serine. + + 18025465 + PubMed + + + 6893271 + PubMed + + + AA0195#CYS + RESID + + + + (R)-2-amino-3-hydroxypropanoic acid + RESID-systematic + + + D-serine + RESID-name + + + + DiffAvg + -16.06 + + + + DiffFormula + C 0 H 0 N 0 O 1 S -1 + + + + DiffMono + -15.977156 + + + + Formula + C 3 H 5 N 1 O 2 + + + + MassAvg + 87.08 + + + + MassMono + 87.032028 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00891 + MOD:00905 + PSI-MOD + + + MOD:00893 + residues isobaric at 128.0-128.1 + + Natural or modified residues with a mass of 128.0-128.1 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00616 + PSI-MOD + + + MOD:00894 + residues isobaric at 128.058578 Da + + Natural or modified resiues with a mass of 128.058578 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00569 + MOD:00893 + PSI-MOD + + + MOD:00895 + FAD modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00697 + MOD:00861 + PSI-MOD + + + MOD:00896 + FMN modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00697 + MOD:00861 + PSI-MOD + + + MOD:00897 + N-acetyl-S-archeol-cysteine + + A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine. + + AA0043#var + RESID + + + AA0223#var + RESID + + + + + DiffAvg + 677.20 + + + + DiffFormula + C 45 H 88 N 0 O 3 S 0 + + + + DiffMono + 676.673347 + + + + Formula + C 48 H 93 N 1 O 4 S 1 + + + + MassAvg + 780.34 + + + + MassMono + 779.682531 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + + has_functional_parent + MOD:000520 + + + has_functional_parent + MOD:002280 + + PSI-MOD + + + MOD:00898 + S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. + + 10896212 + PubMed + + + 4575979 + PubMed + + + 9056182 + PubMed + + + AA0107#var + RESID + + + 377 + UniMod + + + Incidental to RESID:AA0060. + + Diacylglycerol + PSI-MS-label + + + diacylglycerol + UniMod-description + + + + DiffAvg + 576.95 + + + + DiffFormula + C 37 H 68 N 0 O 4 S 0 + + + + DiffMono + 576.511761 + + + + Formula + C 40 H 73 N 1 O 5 S 1 + + + + MassAvg + 680.09 + + + + MassMono + 679.520945 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00116 + PSI-MOD + + + MOD:00899 + N-palmitoyl-S-diacylglycerol-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine. + + AA0069#var + RESID + + + AA0107#var + RESID + + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + + has_functional_parent + MOD:000690 + + + has_functional_parent + MOD:001160 + + PSI-MOD + + + MOD:00900 + N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine + + A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. + + 18688235 + PubMed + + + + (R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid + PSI-MOD-alternate + + + 2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid + PSI-MOD-alternate + + + + DiffAvg + 815.36 + + + + DiffFormula + C 53 H 98 N 0 O 5 S 0 + + + + DiffMono + 814.741426 + + + + Formula + C 56 H 103 N 1 O 6 S 1 + + + + MassAvg + 918.50 + + + + MassMono + 917.750611 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00899 + + has_functional_parent + MOD:000690 + + + has_functional_parent + MOD:008980 + + PSI-MOD + + + MOD:00901 + modified L-alanine residue + + A protein modification that modifies an L-alanine. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModAla + PSI-MOD-label + + + + Origin + A + + MOD:01157 + PSI-MOD + + + MOD:00902 + modified L-arginine residue + + A protein modification that modifies an L-arginine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModArg + PSI-MOD-label + + + + Origin + R + + MOD:01157 + PSI-MOD + + + MOD:00903 + modified L-asparagine residue + + A protein modification that modifies an L-asparagine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModAsn + PSI-MOD-label + + + + Origin + N + + MOD:01157 + PSI-MOD + + + MOD:00904 + modified L-aspartic acid residue + + A protein modification that modifies an L-aspartic acid residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModAsp + PSI-MOD-label + + + + Origin + D + + MOD:01157 + PSI-MOD + + + MOD:00905 + modified L-cysteine residue + + A protein modification that modifies an L-cysteine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModCys + PSI-MOD-label + + + + Origin + C + + MOD:01157 + PSI-MOD + + + MOD:00906 + modified L-glutamic acid residue + + A protein modification that modifies an L-glutamic acid residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModGlu + PSI-MOD-label + + + + Origin + E + + MOD:01157 + PSI-MOD + + + MOD:00907 + modified L-glutamine residue + + A protein modification that modifies an L-glutamine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModGln + PSI-MOD-label + + + + Origin + Q + + MOD:01157 + PSI-MOD + + + MOD:00908 + modified glycine residue + + A protein modification that modifies a glycine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModGly + PSI-MOD-label + + + + Origin + G + + MOD:01157 + PSI-MOD + + + MOD:00909 + modified L-histidine residue + + A protein modification that modifies an L-histidine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModHis + PSI-MOD-label + + + + Origin + H + + MOD:01157 + PSI-MOD + + + MOD:00910 + modified L-isoleucine residue + + A protein modification that modifies an L-isoleucine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModIle + PSI-MOD-label + + + + Origin + I + + MOD:01157 + PSI-MOD + + + MOD:00911 + modified L-leucine residue + + A protein modification that modifies an L-leucine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModLeu + PSI-MOD-label + + + + Origin + L + + MOD:01157 + PSI-MOD + + + MOD:00912 + modified L-lysine residue + + A protein modification that modifies an L-lysine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModLys + PSI-MOD-label + + + + Origin + K + + MOD:01157 + PSI-MOD + + + MOD:00913 + modified L-methionine residue + + A protein modification that modifies an L-methionine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModMet + PSI-MOD-label + + + + Origin + M + + MOD:01157 + PSI-MOD + + + MOD:00914 + modified L-phenylalanine residue + + A protein modification that modifies an L-phenylalanine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModPhe + PSI-MOD-label + + + + Origin + F + + MOD:01157 + PSI-MOD + + + MOD:00915 + modified L-proline residue + + A protein modification that modifies an L-proline residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModPro + PSI-MOD-label + + + + Origin + P + + MOD:01157 + PSI-MOD + + + MOD:00916 + modified L-serine residue + + A protein modification that modifies an L-serine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModSer + PSI-MOD-label + + + + Origin + S + + MOD:01157 + PSI-MOD + + + MOD:00917 + modified L-threonine residue + + A protein modification that modifies an L-threonine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModThr + PSI-MOD-label + + + + Origin + T + + MOD:01157 + PSI-MOD + + + MOD:00918 + modified L-tryptophan residue + + A protein modification that modifies an L-tryptophan residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModTrp + PSI-MOD-label + + + + Origin + W + + MOD:01157 + PSI-MOD + + + MOD:00919 + modified L-tyrosine residue + + A protein modification that modifies an L-tyrosine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModTyr + PSI-MOD-label + + + + Origin + Y + + MOD:01157 + PSI-MOD + + + MOD:00920 + modified L-valine residue + + A protein modification that modifies an L-valine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + ModVal + PSI-MOD-label + + + + Origin + V + + MOD:01157 + PSI-MOD + + + MOD:00921 + new uncategorized UniMod entries + + New uncategorized UniMod. OBSOLETE because organizational use is no longer required. + + 18688235 + PubMed + + + 1 + PSI-MOD + + + MOD:00922 + Cy3 CyDye DIGE Fluor saturation dye + + modification from UniMod Chemical derivative + + 494 + UniMod + + + + Cy3 CyDye DIGE Fluor saturation dye + UniMod-description + + + CyDye-Cy3 + UniMod-interim + + + + DiffAvg + 672.84 + + + + DiffFormula + C 37 H 44 N 4 O 6 S 1 + + + + DiffMono + 672.298156 + + + + Formula + C 40 H 49 N 5 O 7 S 2 + + + + MassAvg + 775.98 + + + + MassMono + 775.307341 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00923 + Cy5 CyDye DIGE Fluor saturation dye + + modification from UniMod Chemical derivative + + 495 + UniMod + + + + Cy5 CyDye DIGE Fluor saturation dye + UniMod-description + + + CyDye-Cy5 + UniMod-interim + + + + DiffAvg + 684.85 + + + + DiffFormula + C 38 H 44 N 4 O 6 S 1 + + + + DiffMono + 684.298156 + + + + Formula + C 41 H 49 N 5 O 7 S 2 + + + + MassAvg + 787.99 + + + + MassMono + 787.307341 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00924 + N6-(L-threonyl)-L-lysine + + A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine. + + 18063774 + PubMed + + + AA0440 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid + RESID-systematic + + + N6-(L-threonyl)-L-lysine + RESID-name + + + N6-threonyl-lysine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 10 H 18 N 3 O 3 + + + + MassAvg + 228.27 + + + + MassMono + 228.134816 + + + + Origin + K, T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00688 + MOD:00917 + MOD:00954 + MOD:01875 + PSI-MOD + + + MOD:00925 + heptosylated residue + + A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond. + + 490 + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00693 + PSI-MOD + + + MOD:00926 + Bisphenol A diglycidyl ether derivative + + Modification from UniMod Non-standard residue. OBSOLETE because not an amino acid modification. From UniMod not an approved entry. + + 11225353 + PubMed + + + 493 + UniMod + + + + BADGE + UniMod-interim + + + Bisphenol A diglycidyl ether derivative + UniMod-description + + + + DiffAvg + 340.42 + + + + DiffFormula + C 21 H 24 O 4 + + + + DiffMono + 340.167459 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00927 + 2x(13)C,4x(2)H labeled dimethylated residue + + A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue. + + 16335955 + PubMed + + + 3802193 + PubMed + + + 510 + UniMod + + + + DiMethyl-C13HD2 + UniMod-description + + + Dimethyl:2H(4)13C(2) + PSI-MS-label + + + + DiffAvg + 34.06 + + + + DiffFormula + (13)C 2 (2)H 4 + + + + DiffMono + 34.063117 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00842 + PSI-MOD + + + MOD:00928 + [3-(2,5)-dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium + + modification from UniMod Chemical derivative + + 16771548 + PubMed + + + 513 + UniMod + + + Should have children for K and X-N-term [JSG]. + + [3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium + UniMod-description + + + C8-QAT + UniMod-interim + + + + DiffAvg + 227.39 + + + + DiffFormula + C 14 H 29 N 1 O 1 + + + + DiffMono + 227.224915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00929 + lactose glycated lysine + + A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct. + + 9606156 + PubMed + + + 512 + UniMod + + + The term lactosylation used with this meaning is a misnomer [JSG]. + + Hex(2) + UniMod-interim + + + Lactosylation + UniMod-description + + + + DiffAvg + 342.30 + + + + DiffFormula + C 12 H 22 O 11 + + + + DiffMono + 342.116212 + + + + Formula + C 18 H 34 N 2 O 12 + + + + MassAvg + 470.47 + + + + MassMono + 470.211175 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00767 + MOD:00912 + PSI-MOD + + + MOD:00930 + propyl-NAG tyrosine adduct + + tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline. + + 15795231 + PubMed + + + 514 + UniMod + + + + + DiffAvg + 232.27 + + + + DiffFormula + C 9 H 14 N 1 O 4 S 1 + + + + DiffMono + 232.064354 + + + + Formula + C 18 H 23 N 2 O 6 S 1 + + + + MassAvg + 395.45 + + + + MassMono + 395.127682 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00919 + PSI-MOD + + + MOD:00931 + Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K + + modification from UniMod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups + + 11085420 + PubMed + + + 498 + UniMod + + + + BHTOH + UniMod-interim + + + Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K + UniMod-description + + + + DiffAvg + 234.34 + + + + DiffFormula + C 15 H 22 O 2 + + + + DiffMono + 234.161980 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00932 + IDBEST tag for quantitation + + modification from UniMod Isotopic label + + 11821862 + PubMed + + + 499 + UniMod + + + + Heavy IDBEST tag for quantitation + UniMod-description + + + IGBP:13C(2) + PSI-MS-label + + + + DiffAvg + 298.02 + + + + DiffFormula + Br 1 (12)C 10 (13)C 2 H 13 N 2 O 2 + + + + DiffMono + 298.022749 + + + + Formula + Br 1 (12)C 13 (13)C 2 H 18 N 3 O 3 S 1 + + + + MassAvg + 401.03 + + + + MassMono + 401.031934 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + MOD:01426 + PSI-MOD + + + MOD:00933 + methylglyoxal arginine adduct (+54 amu) + + modification from UniMod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu) + + 319#R + UniMod + + + Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52. + + Delta:H(2)C(3)O(1) + PSI-MS-label + + + MDA adduct +54 + UniMod-description + + + + DiffAvg + 54.05 + + + + DiffFormula + C 3 H 2 O 1 + + + + DiffMono + 54.010565 + + + + Formula + C 9 H 14 N 4 O 2 + + + + MassAvg + 210.24 + + + + MassMono + 210.111676 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00630 + MOD:00902 + PSI-MOD + + + MOD:00934 + Levuglandinyl - arginine hydroxylactam adduct + + modification from UniMod Post-translational + + 506 + UniMod + + + + Levuglandinyl - arginine hydroxylactam adduct + UniMod-description + + + LG-Hlactam-R + UniMod-interim + + + + DiffAvg + 306.40 + + + + DiffFormula + C 19 H 26 N -2 O 5 + + + + DiffMono + 306.171876 + + + + Formula + C 25 H 38 N 2 O 6 + + + + MassAvg + 462.59 + + + + MassMono + 462.272987 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00846 + MOD:00902 + PSI-MOD + + + MOD:00935 + methionine oxidation with neutral loss of 64 Da + + Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH. + + 18688235 + PubMed + + + 9004526 + PubMed + + + Originally created from UniMod:507 that was later deleted. + + + DiffAvg + -64.10 + + + + DiffFormula + C -1 H -4 N 0 O -1 S -1 + + + + DiffMono + -63.998286 + + + + Formula + C 4 H 5 N 1 O 1 S 0 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00431 + MOD:00913 + PSI-MOD + + + MOD:00936 + Levuglandinyl - hydroxylactam adduct, K and N-term + + modification from UniMod Post-translational + + 504 + UniMod + + + + Levuglandinyl - lysine hydroxylactam adduct + UniMod-description + + + LG-Hlactam-K + UniMod-interim + + + + DiffAvg + 348.44 + + + + DiffFormula + C 20 H 28 O 5 + + + + DiffMono + 348.193674 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00846 + PSI-MOD + + + MOD:00937 + Levuglandinyl - arginine lactam adduct + + modification from UniMod Post-translational + + 505 + UniMod + + + + Levuglandinyl - arginine lactam adduct + UniMod-description + + + LG-lactam-R + UniMod-interim + + + + DiffAvg + 290.40 + + + + DiffFormula + C 19 H 26 N -2 O 4 + + + + DiffMono + 290.176961 + + + + Formula + C 25 H 38 N 2 O 5 + + + + MassAvg + 446.59 + + + + MassMono + 446.278072 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00846 + MOD:00902 + PSI-MOD + + + MOD:00938 + Levuglandinyl - lactam adduct, K and N-term + + modification from UniMod Post-translational + + 12590383 + PubMed + + + 503 + UniMod + + + + Levuglandinyl - lysine lactam adduct + UniMod-description + + + LG-lactam-K + UniMod-interim + + + + DiffAvg + 332.44 + + + + DiffFormula + C 20 H 28 O 4 + + + + DiffMono + 332.198759 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00846 + PSI-MOD + + + MOD:00939 + hydrolyzed N-methylmaleimide cysteine adduct + + modification from UniMod Chemical derivative + + 500 + UniMod + + + + Nmethylmaleimide+water + UniMod-interim + + + Nmethylmaleimidehydrolysis + UniMod-description + + + + DiffAvg + 129.12 + + + + DiffFormula + C 5 H 7 N 1 O 3 + + + + DiffMono + 129.042593 + + + + Formula + C 8 H 12 N 2 O 4 S 1 + + + + MassAvg + 232.25 + + + + MassMono + 232.051778 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00940 + 3-methyl-2-pyridyl isocyanate derivatized residue + + A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate. + + 11078590 + PubMed + + + 501 + UniMod + + + + 3-methyl-2-pyridyl isocyanate + UniMod-description + + + PyMIC + UniMod-interim + + + + DiffAvg + 134.14 + + + + DiffFormula + C 7 H 6 N 2 O 1 + + + + DiffMono + 134.048013 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00840 + PSI-MOD + + + MOD:00941 + dehydropyrrolizidine alkaloid (dehydroretronecine) derivatized cysteine + + modification from UniMod Chemical derivative + + 12175151 + PubMed + + + 488 + UniMod + + + + Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines + UniMod-description + + + DHP + UniMod-interim + + + + DiffAvg + 118.16 + + + + DiffFormula + C 8 H 8 N 1 + + + + DiffMono + 118.065674 + + + + Formula + C 11 H 13 N 2 S 1 + + + + MassAvg + 205.30 + + + + MassMono + 205.079944 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:00942 + (4,4,5,5-(2)H4)-L-lysine + + A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine. + + 481 + UniMod + + + For SILAC experiments. + + 4,4,5,5-D4 Lysine + UniMod-description + + + 4,4,5,5-tetradeuterolysine + PSI-MOD-alternate + + + Label:2H(4) + UniMod-interim + + + lys-2H4 + OMSSA-label + + + + DiffAvg + 4.03 + + + + DiffFormula + (1)H -4 (2)H 4 + + + + DiffMono + 4.025107 + + + + Formula + C 6 (1)H 8 (2)H 4 N 2 O 1 + + + + MassAvg + 132.12 + + + + MassMono + 132.120070 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00837 + MOD:00912 + PSI-MOD + + + MOD:00943 + 4-trimethylammoniumbutanoyl derivatized residue + + modification from UniMod Isotopic label + + 12643539 + PubMed + + + 476 + UniMod + + + + 4-trimethyllammoniumbutyryl- + UniMod-description + + + TMAB + UniMod-interim + + + + DiffAvg + 128.19 + + + + DiffFormula + C 7 H 14 N 1 O 1 + + + + DiffMono + 128.107539 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00944 + d9-4-trimethylammoniumbutanoyl derivatized residue + + modification from UniMod Isotopic label + + 477 + UniMod + + + + d9-4-trimethyllammoniumbutyryl- + UniMod-description + + + TMAB:2H(9) + UniMod-interim + + + + DiffAvg + 137.16 + + + + DiffFormula + C 7 (1)H 5 (2)H 9 N 1 O 1 + + + + DiffMono + 137.164030 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00943 + MOD:01431 + PSI-MOD + + + MOD:00945 + fluorescein-5-thiosemicarbazide adduct + + OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626. + + 18688235 + PubMed + + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00946 + crosslinked residues with loss of ammonia + + A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + PSI-MOD + + + MOD:00947 + DeltaMass + + Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all. + + 18688235 + PubMed + + + MOD:00032 + PSI-MOD + + + MOD:00948 + 5'-dephospho + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: -79 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00949 + desmosine + + OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: -58 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00950 + decomposed carboxymethylated methionine + + modification from DeltaMass + + 3 + DeltaMass + + + From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + M + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00951 + L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide + + Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment. + + 58 + DeltaMass + + + From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI. + + d4CbxGlu + PSI-MOD-label + + + + DiffAvg + -44.01 + + + + DiffFormula + C -1 H 0 N 0 O -2 + + + + DiffMono + -43.989829 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00015 + MOD:00906 + MOD:00957 + MOD:00960 + PSI-MOD + + + MOD:00952 + (2-aminosuccinimidyl)acetic acid (Asp) + + A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule. + + 10801322 + PubMed + + + AA0441#ASP + RESID + + + Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue. + PSI-MOD-slim + + (2-aminosuccinimidyl)acetic acid + RESID-name + + + (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid + RESID-alternate + + + [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid + RESID-systematic + + + anhydroaspartyl glycine + RESID-alternate + + + aspartimide glycine + RESID-alternate + + + CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly) + UniProt-feature + + + N-(2-aminosuccinyl)glycine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 6 N 2 O 3 + + + + MassAvg + 154.13 + + + + MassMono + 154.037842 + + + + Origin + D, G + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00904 + MOD:00954 + MOD:01628 + PSI-MOD + + + MOD:00953 + O-(L-isoglutamyl)-L-serine (Glu-Ser) + + A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine. + + 0 + DeltaMass + + + 19035375 + PubMed + + + AA0597#ESX + RESID + + + Cross-link 2; From DeltaMass: with no citation. + + (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid + RESID-systematic + + + CROSSLNK isoglutamyl serine ester (Ser-Glu) + UniProt-feature + + + O(beta)-(gamma-glutamyl)serine + RESID-alternate + + + O-(L-isoglutamyl)-L-serine + RESID-name + + + O-gamma-Glutamyl- (Crosslink to Serine) + DeltaMass-label + + + O3-(isoglutamyl)-serine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 8 H 10 N 2 O 4 + + + + MassAvg + 198.18 + + + + MassMono + 198.064057 + + + + Origin + E, S + + + + Source + artifact + + + + TermSpec + none + + MOD:00906 + MOD:00954 + MOD:01977 + PSI-MOD + + + MOD:00954 + crosslinked residues with loss of water + + A protein modification that crosslinks two residues with a covalent bond and the loss of water. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + PSI-MOD + + + MOD:00955 + alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine) + + A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine. + + 0 + DeltaMass + + + Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG]. + + beta-alaninohistidine + PSI-MOD-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 9 H 10 N 4 O 2 + + + + MassAvg + 206.20 + + + + MassMono + 206.080376 + + + + Origin + H, S + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:00916 + MOD:00954 + PSI-MOD + + + MOD:00956 + misincorporation of norleucine for methionine + + modification from DeltaMass + + 10 + DeltaMass + + + From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration. + + + DiffAvg + -18.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 S -1 + + + + DiffMono + -17.956421 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + M + + + + Source + none + + + + TermSpec + none + + MOD:01026 + PSI-MOD + + + MOD:00957 + modified residue with neutral loss of carbon dioxide + + Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment. + + 18688235 + PubMed + + + + dCO2ModRes + PSI-MOD-label + + + + DiffAvg + -44.01 + + + + DiffFormula + C -1 H 0 N 0 O -2 + + + + DiffMono + -43.989829 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00431 + PSI-MOD + + + MOD:00958 + crosslink between Arg and His sidechains + + modification from DeltaMass + + 0 + DeltaMass + + + Cross-link 2; From DeltaMass: Average Mass: -5 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + H, R + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00959 + 3,3',5,5'-TerTyr (Crosslink) + + modification from DeltaMass + + 0 + DeltaMass + + + Cross-link 4; From DeltaMass: Average Mass: -4 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Y, Y, Y, Y + + + + Source + none + + + + TermSpec + none + + MOD:00692 + PSI-MOD + + + MOD:00960 + decarboxylated residue + + A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom. + + 18688235 + PubMed + + + + + DiffAvg + -44.01 + + + + DiffFormula + C -1 H 0 N 0 O -2 + + + + DiffMono + -43.989829 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:00961 + reduction of disulfide crosslink in cystine to two cysteines + + A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues. + + 333 + DeltaMass + + + Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine. + PSI-MOD-slim + + + DiffAvg + 2.02 + + + + DiffFormula + C 0 H 2 N 0 O 0 S 0 + + + + DiffMono + 2.015650 + + + + Formula + C 6 H 10 N 2 O 2 S 2 + + + + MassAvg + 206.28 + + + + MassMono + 206.018370 + + + + Origin + MOD:00034 + + + + Source + none + + + + TermSpec + none + + MOD:00905 + MOD:01473 + + derives_from + MOD:000340 + + PSI-MOD + + + MOD:00962 + 2',3'-dihydrotryptophan + + A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan. + + 343 + DeltaMass + + + From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG]. + + + DiffAvg + 2.02 + + + + DiffFormula + C 0 H 2 N 0 O 0 S 0 + + + + DiffMono + 2.015650 + + + + Formula + C 11 H 12 N 2 O 1 + + + + MassAvg + 188.23 + + + + MassMono + 188.094963 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00918 + MOD:01473 + PSI-MOD + + + MOD:00963 + Oxidation of Trp to kynurenine + + Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462. + + 357 + DeltaMass + + + From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00964 + lysine epsilon amino to imine + 12 amu + + modification from DeltaMass + + 34 + DeltaMass + + + From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt. + + N6-(methylidene)-lysine + PSI-MOD-alternate + + + + DiffAvg + 12.01 + + + + DiffFormula + C 1 H 0 N 0 O 0 + + + + DiffMono + 12.000000 + + + + Formula + C 7 H 12 N 2 O 1 + + + + MassAvg + 140.19 + + + + MassMono + 140.094963 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00965 + 4-thiazolidinecarboxylic acid + + A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid. + + 342 + DeltaMass + + + From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501. + + thioproline + DeltaMass-label + + + + DiffAvg + 12.01 + + + + DiffFormula + C 1 H 0 N 0 O 0 S 0 + + + + DiffMono + 12.000000 + + + + Formula + C 4 H 6 N 1 O 1 S 1 + + + + MassAvg + 116.16 + + + + MassMono + 116.017010 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00905 + PSI-MOD + + + MOD:00966 + 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid + + A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. + + 339 + DeltaMass + + + From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red. + + + DiffAvg + 12.01 + + + + DiffFormula + C 1 H 0 N 0 O 0 S 0 + + + + DiffMono + 12.000000 + + + + Formula + C 12 H 10 N 2 O 1 + + + + MassAvg + 198.22 + + + + MassMono + 198.079313 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00918 + PSI-MOD + + + MOD:00967 + syndesine + + A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine. + + 35 + DeltaMass + + + 75151974 + PubMed + + + Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG]. + + hydroxylysinohydroxynorleucine + PSI-MOD-alternate + + + + DiffAvg + 16.96 + + + + DiffFormula + C 0 H -3 N -2 O 3 + + + + DiffMono + 16.955121 + + + + Formula + C 12 H 21 N 2 O 5 + + + + MassAvg + 273.31 + + + + MassMono + 273.145047 + + + + Origin + K, K + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00968 + CM-Cys vs PAM-Cys + + modification from DeltaMass + + 347 + DeltaMass + + + From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00969 + CAM-Cys vs PAM-Cys + + modification from DeltaMass + + 346 + DeltaMass + + + From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00970 + delta-hydroxy-allysine (Lys) + + modification from DeltaMass + + 37 + DeltaMass + + + From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00971 + Oxohistidine (from histidine) + + modification from DeltaMass + + 38 + DeltaMass + + + From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + H + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00972 + monobrominated L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine. + + 340#F + UniMod + + + From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa + + Br1Phe + PSI-MOD-label + + + bromination + UniMod-description + + + Bromo + PSI-MS-label + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 9 H 8 N 1 O 1 + + + + MassAvg + 226.07 + + + + MassMono + 224.978926 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:01066 + MOD:01912 + PSI-MOD + + + MOD:00973 + Oxidation of proline (to glutamic acid) + + modification from DeltaMass + + 355 + DeltaMass + + + From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished) + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00974 + (35)Cl labeled 3'-chlorotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 34 + + + DiffAvg + 33.96 + + + + DiffFormula + (35)Cl 1 H -1 + + + + DiffMono + 33.961028 + + + + Formula + C 9 (35)Cl 1 H 8 N 1 O 2 + + + + MassAvg + 197.02 + + + + MassMono + 197.024356 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01046 + PSI-MOD + + + MOD:00975 + (37)Cl labeled 3'-chlorotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 36 + + + DiffAvg + 35.96 + + + + DiffFormula + (37)Cl 1 H -1 + + + + DiffMono + 35.958078 + + + + Formula + C 9 (37)Cl 1 H 8 N 1 O 2 + + + + MassAvg + 199.02 + + + + MassMono + 199.021406 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01046 + PSI-MOD + + + MOD:00976 + potassium salt + + modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 38 + + + DiffAvg + 38.09 + + + + DiffFormula + H -1 K 1 + + + + DiffMono + 37.955882 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00977 + disodium salt + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 44 + PSI-MOD-slim + + + DiffAvg + 43.96 + + + + DiffFormula + H -2 Na 2 + + + + DiffMono + 43.963888 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00747 + PSI-MOD + + + MOD:00978 + piperidine adduct to C-terminal Cys + + modification from DeltaMass + + 345 + DeltaMass + + + From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00979 + t-butyl ester (OtBu) and t-butyl (tBu) + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 56 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00980 + Carboxamidomethyl (on Cysteine) + + modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. + + 337 + DeltaMass + + + From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00981 + sodium and potassium salt + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 60 + PSI-MOD-slim + + + DiffAvg + 60.07 + + + + DiffFormula + H -2 K 1 Na 1 + + + + DiffMono + 59.937826 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00747 + MOD:00849 + PSI-MOD + + + MOD:00982 + L-selenocysteine (Ser) + + A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process). + + 0 + DeltaMass + + + [From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG]. + + Sec(Ser) + PSI-MOD-label + + + Selenocysteine (from Serine) + DeltaMass-label + + + + DiffAvg + 62.97 + + + + DiffFormula + C 0 H 0 N 0 O -1 Se 1 + + + + DiffMono + 63.921607 + + + + Formula + C 3 H 5 N 1 O 1 Se 1 + + + + MassAvg + 150.05 + + + + MassMono + 150.953635 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00031 + MOD:00916 + PSI-MOD + + + MOD:00983 + Asp transamidation with piperidine + + modification from DeltaMass + + 67 + DeltaMass + + + From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00984 + (35)Cl labeled 3',5'-dichlorotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 68 + + + DiffAvg + 67.92 + + + + DiffFormula + (35)Cl 2 H -2 + + + + DiffMono + 67.922055 + + + + Formula + C 9 (35)Cl 2 H 7 N 1 O 2 + + + + MassAvg + 230.99 + + + + MassMono + 230.985384 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01045 + PSI-MOD + + + MOD:00985 + halogenated tyrosine + + A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + HalTyr + PSI-MOD-label + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:00694 + MOD:00919 + PSI-MOD + + + MOD:00986 + (35)Cl and (37)Cl labeled 3',5'-dichlorotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 70. + + + DiffAvg + 69.92 + + + + DiffFormula + (35)Cl 1 (37)Cl 1 H -2 + + + + DiffMono + 69.919105 + + + + Formula + C 9 (35)Cl 1 (37)Cl 1 H 7 N 1 O 2 + + + + MassAvg + 232.98 + + + + MassMono + 232.982434 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01045 + PSI-MOD + + + MOD:00987 + chlorinated tyrosine + + A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom. + + 18688235 + PubMed + + + + ClTyr + PSI-MOD-label + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:00753 + MOD:00985 + PSI-MOD + + + MOD:00988 + brominated tyrosine + + A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom. + + 18688235 + PubMed + + + + BrTyr + PSI-MOD-label + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:00754 + MOD:00985 + PSI-MOD + + + MOD:00989 + acetamidomethyl (Acm) + + OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079. + + 0 + DeltaMass + + + From DeltaMass with no citation or formula. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:00990 + (37)Cl labeled 3',5'-dichlorotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 72 + + + DiffAvg + 71.92 + + + + DiffFormula + (37)Cl 2 H -2 + + + + DiffMono + 71.916155 + + + + Formula + C 9 (37)Cl 2 H 7 N 1 O 2 + + + + MassAvg + 234.98 + + + + MassMono + 234.979484 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01045 + PSI-MOD + + + MOD:00991 + S-(sn-1-glyceryl)-L-cysteine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 74 with no citation. + + + DiffAvg + 74.08 + + + + DiffFormula + C 3 H 6 O 2 + + + + DiffMono + 74.036779 + + + + Formula + C 6 H 11 N 1 O 3 S 1 + + + + MassAvg + 177.22 + + + + MassMono + 177.045964 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:00992 + glutamate 5-glycerol ester + + modification from DeltaMass + + 78 + DeltaMass + + + 18767873 + PubMed + + + From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG]. + + + DiffAvg + 74.08 + + + + DiffFormula + C 3 H 6 O 2 + + + + DiffMono + 74.036779 + + + + Formula + C 8 H 13 N 1 O 5 + + + + MassAvg + 203.19 + + + + MassMono + 203.079373 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00906 + PSI-MOD + + + MOD:00993 + phenyl ester + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 76, on acidic amino acids + + OPh + DeltaMass-label + + + + DiffAvg + 76.10 + + + + DiffFormula + C 6 H 4 + + + + DiffMono + 76.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00994 + (79)Br labeled 3'-bromotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 78 + + + DiffAvg + 77.91 + + + + DiffFormula + (79)Br 1 H -1 + + + + DiffMono + 77.910512 + + + + Formula + (79)Br 1 C 9 H 8 N 1 O 2 + + + + MassAvg + 240.97 + + + + MassMono + 240.973841 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01025 + PSI-MOD + + + MOD:00995 + (81)Br labeled 2'-bromophenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 80 + + + DiffAvg + 79.91 + + + + DiffFormula + (81)Br 1 H -1 + + + + DiffMono + 79.908466 + + + + Formula + (81)Br 1 C 9 H 8 N 1 O 1 + + + + MassAvg + 226.98 + + + + MassMono + 226.976879 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00183 + PSI-MOD + + + MOD:00996 + (81)Br labeled 3'-bromotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 80 + + + DiffAvg + 79.91 + + + + DiffFormula + (81)Br 1 H -1 + + + + DiffMono + 79.908466 + + + + Formula + (81)Br 1 C 9 H 8 N 1 O 2 + + + + MassAvg + 242.97 + + + + MassMono + 242.971794 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01025 + PSI-MOD + + + MOD:00997 + cyclohexyl ester + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 82 + + OcHex + DeltaMass-label + + + + DiffAvg + 82.15 + + + + DiffFormula + C 6 H 10 + + + + DiffMono + 82.078250 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:00998 + iodinated tyrosine + + A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom. + + 18688235 + PubMed + + + PSI-MOD-slim + + ITyr + PSI-MOD-label + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:00755 + MOD:00985 + PSI-MOD + + + MOD:00999 + homoseryl lactone + + OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404. + + 90 + DeltaMass + + + From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01000 + monobrominated tyrosine + + A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom. + + 18688235 + PubMed + + + + Br1Tyr + PSI-MOD-label + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:00988 + PSI-MOD + + + MOD:01001 + 2-aminoisobutyric acid residue (Aib) + + A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid. + + 0 + DeltaMass + + + Modification from DeltaMass: Average Mass: 85. + + 2-amino-2-methylpropanoic acid + PSI-MOD-alternate + + + 2-amino-2-methylpropionic acid + PSI-MOD-alternate + + + 2-methylalanine + PSI-MOD-alternate + + + Aib + PSI-MOD-alternate + + + alpha,alpha-dimethylglycine + PSI-MOD-alternate + + + alpha-aminoisobutyric acid + PSI-MOD-alternate + + + alpha-methylalanine + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 4 H 7 N 1 O 1 + + + + MassAvg + 85.11 + + + + MassMono + 85.052764 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00850 + PSI-MOD + + + MOD:01002 + gamma-aminobutyryl + + modification from DeltaMass + + 92 + DeltaMass + + + From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106 + + + DiffAvg + 85.11 + + + + DiffFormula + C 4 H 7 N 1 O 1 + + + + DiffMono + 85.052764 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01003 + t-butyloxymethyl (Bum) + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 86 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01004 + diaminopropionyl + + modification from DeltaMass + + 95 + DeltaMass + + + From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094 + + + DiffAvg + 86.09 + + + + DiffFormula + C 3 H 6 N 2 O 1 + + + + DiffMono + 86.048013 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01005 + t-butylsulfenyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 88 + + StBu + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01006 + dibrominated tyrosine + + A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms. + + 534 + UniMod + + + + Br2Tyr + PSI-MOD-label + + + Dibromo + PSI-MS-label + + + Dibromo + UniMod-description + + + + DiffAvg + 157.79 + + + + DiffFormula + Br 2 C 0 H -2 N 0 O 0 + + + + DiffMono + 155.821024 + + + + Formula + Br 2 C 9 H 7 N 1 O 2 + + + + MassAvg + 320.97 + + + + MassMono + 318.884353 + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:00988 + PSI-MOD + + + MOD:01007 + anisyl modified residue + + A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position. + + 0 + DeltaMass + + + From DeltaMass with no citation or formula: Average Mass: 90. + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01008 + benzyl (Bzl) and benzyl ester (OBzl) modified residue + + A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom. + + 0 + DeltaMass + + + From DeltaMass with no citation or formula: Average Mass: 90 + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01009 + dehydrogenated proline + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass with no citation. + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 5 H 5 N 1 O 1 + + + + MassAvg + 95.10 + + + + MassMono + 95.037114 + + + + Origin + P + + + + Source + none + + + + TermSpec + none + + MOD:00915 + MOD:01888 + PSI-MOD + + + MOD:01010 + trifluoroacetylated residue + + A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom. + + 0 + DeltaMass + + + + TFA + DeltaMass-label + + + + DiffAvg + 96.01 + + + + DiffFormula + C 2 F 3 H -1 O 1 + + + + DiffMono + 95.982299 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00498 + MOD:00649 + MOD:00848 + PSI-MOD + + + MOD:01011 + N-hydroxysuccinimide (ONSu, OSu) + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 97 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01012 + oxidation of disulfide crosslink in cystine to two cysteic acids + + A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues. + + 335 + DeltaMass + + + Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. + + + DiffAvg + 98.01 + + + + DiffFormula + C 0 H 2 N 0 O 6 S 0 + + + + DiffMono + 97.985138 + + + + Formula + C 6 H 10 N 2 O 8 S 2 + + + + MassAvg + 302.27 + + + + MassMono + 301.987857 + + + + Origin + MOD:00034 + + + + Source + artifact + + + + TermSpec + none + + MOD:00460 + + derives_from + MOD:000340 + + PSI-MOD + + + MOD:01013 + tetramethylguanidinium termination by-product on amine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 98 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01014 + phosphate/sulphate adduct of proteins + + modification from DeltaMass + + 358 + DeltaMass + + + From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01015 + isovaline residue (Iva) + + A protein modification that inserts or replaces a residue with an isovaline. + + 110 + DeltaMass + + + + 2-amino-2-methylbutanoic acid + PSI-MOD-alternate + + + Isovalyl (-I-,-Iva-) + DeltaMass-label + + + Iva + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 9 N 1 O 1 + + + + MassAvg + 99.13 + + + + MassMono + 99.068414 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00850 + PSI-MOD + + + MOD:01016 + t-butyloxycarbonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 100 + + tBoc + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01017 + homoseryl (-Hse-) + + OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403. + + 113 + DeltaMass + + + From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01018 + 4-methylbenzyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 104 + + Meb + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01019 + hydroxymethylphenyl linker + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 106 + + HMP + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01020 + thioanisyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 106 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01021 + thiocresyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 106 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01022 + 2-piperidinecarboxylic acid + + A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid. + + 0 + DeltaMass + + + + Pip + DeltaMass-label + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 6 H 9 N 1 O 1 + + + + MassAvg + 111.14 + + + + MassMono + 111.068414 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00601 + MOD:00912 + MOD:01160 + PSI-MOD + + + MOD:01023 + 3',5'-dibromo-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine. + + 156 + DeltaMass + + + + 3',5'-Br2Tyr + PSI-MOD-label + + + + DiffAvg + 157.79 + + + + DiffFormula + Br 2 C 0 H -2 N 0 O 0 + + + + DiffMono + 155.821024 + + + + Formula + Br 2 C 9 H 7 N 1 O 2 + + + + MassAvg + 320.97 + + + + MassMono + 318.884353 + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:01006 + PSI-MOD + + + MOD:01024 + monohydroxylated proline + + A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline. + + 0 + DeltaMass + + + 35#P + UniMod + + + From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG]. + PSI-MOD-slim + + Hy1Pro + PSI-MOD-label + + + hydroxylationp + OMSSA-label + + + Hydroxyproline + DeltaMass-label + + + Hyp + DeltaMass-label + + + Oxidation + PSI-MS-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00594 + MOD:00678 + PSI-MOD + + + MOD:01025 + 3'-bromo-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine. + + 18688235 + PubMed + + + + 3'-BrTyr + PSI-MOD-label + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 H -1 + + + + DiffMono + 77.910512 + + + + Formula + Br 1 C 9 H 8 N 1 O 2 + + + + MassAvg + 242.07 + + + + MassMono + 240.973841 + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + MOD:01000 + PSI-MOD + + + MOD:01026 + norleucine residue (Nle) + + A protein modification that inserts or replaces a residue with a norleucine. + + 126 + DeltaMass + + + + Nle + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00850 + PSI-MOD + + + MOD:01027 + t-amyloxycarbonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 114 + + Aoc + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01028 + monochlorinated L-tyrosine + + A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom. + + 18688235 + PubMed + + + + Cl1Tyr + PSI-MOD-label + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 9 Cl 1 H 8 N 1 O 2 + + + + MassAvg + 197.62 + + + + MassMono + 197.024356 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00987 + MOD:01911 + PSI-MOD + + + MOD:01029 + succinylated residue + + A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon. + + 0 + DeltaMass + + + 64 + UniMod + + + From DeltaMass with no citation or formula, Average Mass: 117 [JSG]. + PSI-MOD-slim + + Succinic anhydride labeling reagent light form (N-term & K) + UniMod-description + + + + DiffAvg + 100.07 + + + + DiffFormula + C 4 H 4 O 3 + + + + DiffMono + 100.016044 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:01030 + hydroxybenzotriazole ester + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 117 + + HOBt + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01031 + dimethylbenzyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 118 + + diMeBzl + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01032 + benzyloxymethyl modified residue + + A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Bom + DeltaMass-label + + + + DiffAvg + 120.15 + + + + DiffFormula + C 8 H 8 O 1 + + + + DiffMono + 120.057515 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01033 + p-methoxybenzyl modified residue + + A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Mbzl + DeltaMass-label + + + Mob + DeltaMass-label + + + + DiffAvg + 120.15 + + + + DiffFormula + C 8 H 8 O 1 + + + + DiffMono + 120.057515 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01034 + 4-nitrophenyl modified residue + + A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom. + + 0 + DeltaMass + + + + ONp + DeltaMass-label + + + p-nitrophenyl + DeltaMass-label + + + + DiffAvg + 121.10 + + + + DiffFormula + C 6 H 3 N 1 O 2 + + + + DiffMono + 121.016378 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01035 + chlorobenzyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 125 + + ClBzl + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01036 + O-methyl aspartyl + + OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181. + + 18688235 + PubMed + + + From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + D + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01037 + dichlorinated tyrosine + + A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms. + + 18688235 + PubMed + + + + Cl2Tyr + PSI-MOD-label + + + + DiffAvg + 68.88 + + + + DiffFormula + C 0 Cl 2 H -2 N 0 O 0 + + + + DiffMono + 67.922055 + + + + Formula + C 9 Cl 2 H 7 N 1 O 2 + + + + MassAvg + 232.06 + + + + MassMono + 230.985384 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00987 + PSI-MOD + + + MOD:01038 + norleucine (Nle) + + OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 131. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01039 + hydroxy aspartyl + + OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036. + + 18688235 + PubMed + + + From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 4 H 5 N 1 O 4 + + + + MassAvg + 131.09 + + + + MassMono + 131.021858 + + + + Origin + D + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01040 + penicillamine residue + + A protein modification that inserts or replaces a residue with a penicillamine. + + 154 + DeltaMass + + + From DeltaMass: Name misspelled 'bb-dimethyl cystenyl'. No citation provided. + + 2-amino-3-mercapto-3-methylbutanoic acid + PSI-MOD-alternate + + + 2-amino-3-methyl-3-sulfanylbutanoic acid + PSI-MOD-alternate + + + 3,3-dimethylcysteine + PSI-MOD-alternate + + + 3-mercapto-L-valine + PSI-MOD-alternate + + + beta,beta-dimethylcysteine + DeltaMass-label + + + Pen + DeltaMass-label + + + Pen + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 131.19 + + + + MassMono + 131.040485 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00850 + PSI-MOD + + + MOD:01041 + benzyloxycarbonyl modified residue + + A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Z + DeltaMass-label + + + + DiffAvg + 134.13 + + + + DiffFormula + C 8 H 6 O 2 + + + + DiffMono + 134.036779 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01042 + adamantyl modified residue + + A protein modification that effectively substitutes a adamantyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Ada + DeltaMass-label + + + + DiffAvg + 134.22 + + + + DiffFormula + C 10 H 14 + + + + DiffMono + 134.109550 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01043 + p-nitrobenzyl ester modified residue + + A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group. + + 0 + DeltaMass + + + + ONb + DeltaMass-label + + + + DiffAvg + 135.12 + + + + DiffFormula + C 7 H 5 N 1 O 2 + + + + DiffMono + 135.032028 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01044 + N-methyl glutamyl + + OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080. + + 166 + DeltaMass + + + From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl) + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Q + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01045 + 3',5'-dichloro-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine. + + 18688235 + PubMed + + + + 3',5'-Cl2Tyr + PSI-MOD-label + + + + DiffAvg + 68.88 + + + + DiffFormula + C 0 Cl 2 H -2 N 0 O 0 + + + + DiffMono + 67.922055 + + + + Formula + C 9 Cl 2 H 7 N 1 O 2 + + + + MassAvg + 232.06 + + + + MassMono + 230.985384 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01037 + PSI-MOD + + + MOD:01046 + 3'-chloro-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine. + + 18688235 + PubMed + + + + 3'-ClTyr + PSI-MOD-label + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 9 Cl 1 H 8 N 1 O 2 + + + + MassAvg + 197.62 + + + + MassMono + 197.024356 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01028 + PSI-MOD + + + MOD:01047 + monohydroxylated lysine + + A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine. + + 168 + DeltaMass + + + 35#K + UniMod + + + From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174. + PSI-MOD-slim + + Hy1Lys + PSI-MOD-label + + + Hydroxy Lysyl (-Hyl-) + DeltaMass-label + + + hydroxylationk + OMSSA-label + + + Oxidation + PSI-MS-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 2 O 2 + + + + MassAvg + 144.17 + + + + MassMono + 144.089878 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00681 + PSI-MOD + + + MOD:01048 + 2-pyrrolidone-5-carboxylic acid + + A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid. + + 18688235 + PubMed + + + From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52. + PSI-MOD-slim + + PyrGlu + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 6 N 1 O 2 + + + + MassAvg + 112.11 + + + + MassMono + 112.039853 + + + + Origin + X + + + + Source + none + + + + TermSpec + N-term + + MOD:00601 + MOD:00859 + PSI-MOD + + + MOD:01049 + halogenated histidine + + A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom. + + 18688235 + PubMed + + + + HalHis + PSI-MOD-label + + + + Origin + H + + + + Source + none + + + + TermSpec + none + + MOD:00694 + MOD:00909 + PSI-MOD + + + MOD:01050 + pyridyl alanyl + + modification from DeltaMass + + 180 + DeltaMass + + + From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + A + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01051 + 2-nitrobenzoyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 149 + + NBz + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01052 + dimethoxybenzyl Trp + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 150 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01053 + 2-nitrophenylsulphenyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 153 + + Nps + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01054 + 4-toluenesulfonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 154 + + 4-toluenesulphonyl + DeltaMass-label + + + Tos + DeltaMass-label + + + Tosyl + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01055 + 3-nitro-2-pyridinesulfenyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 154 + + Npys + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01056 + (79)Br labeled 3',5'-dibromotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 156 + + + DiffAvg + 155.82 + + + + DiffFormula + (79)Br 2 C 0 H -2 N 0 O 0 + + + + DiffMono + 155.821024 + + + + Formula + (79)Br 2 C 9 H 7 N 1 O 2 + + + + MassAvg + 318.88 + + + + MassMono + 318.884353 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01023 + PSI-MOD + + + MOD:01057 + (79)Br and (81)Br labeled 3',5'-dibromotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 158 + + + DiffAvg + 157.82 + + + + DiffFormula + (79)Br 1 (81)Br 1 C 0 H -2 N 0 O 0 + + + + DiffMono + 157.818978 + + + + Formula + (79)Br 1 (81)Br 1 C 9 H 7 N 1 O 2 + + + + MassAvg + 320.88 + + + + MassMono + 320.882306 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01023 + PSI-MOD + + + MOD:01058 + dichlorobenzyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 159 + + Dcb + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01059 + (81)Br labeled 3',5'-dibromotyrosine + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 160 + + + DiffAvg + 159.82 + + + + DiffFormula + (81)Br 2 C 0 H -2 N 0 O 0 + + + + DiffMono + 159.816931 + + + + Formula + (81)Br 2 C 9 H 7 N 1 O 2 + + + + MassAvg + 322.88 + + + + MassMono + 322.880260 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:01023 + PSI-MOD + + + MOD:01060 + S-carboxamidomethyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine. + + 196 + DeltaMass + + + 337 + DeltaMass + + + 10504701 + PubMed + + + 11510821 + PubMed + + + 12422359 + PubMed + + + 18306178 + PubMed + + + 4#C + UniMod + + + From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG]. + PSI-MOD-slim + + amidocarboxymethylcysteine + DeltaMass-label + + + CamC + PSI-MOD-alternate + + + CamCys + DeltaMass-label + + + Carbamidomethyl + PSI-MS-label + + + carbamidomethylc + OMSSA-label + + + carbamoylmethylcysteine + DeltaMass-label + + + Carboxamidomethyl (on Cysteine) + DeltaMass-label + + + Carboxyamidomethyl Cystenyl + DeltaMass-label + + + Iodoacetamide derivative + UniMod-description + + + S-carbamoylmethyl-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 S 0 + + + + DiffMono + 57.021464 + + + + Formula + C 5 H 8 N 2 O 2 S 1 + + + + MassAvg + 160.19 + + + + MassMono + 160.030649 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00905 + PSI-MOD + + + MOD:01061 + S-carboxymethyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine. + + 0 + DeltaMass + + + 197 + DeltaMass + + + 6#C + UniMod + + + From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG]. + PSI-MOD-slim + + Carboxymethyl + PSI-MS-label + + + Carboxymethyl cysteine + DeltaMass-label + + + Carboxymethyl Cystenyl + DeltaMass-label + + + carboxymethylc + OMSSA-label + + + CmC + PSI-MOD-alternate + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 N 0 O 2 S 0 + + + + DiffMono + 58.005479 + + + + Formula + C 5 H 7 N 1 O 3 S 1 + + + + MassAvg + 161.18 + + + + MassMono + 161.014664 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00399 + MOD:00905 + PSI-MOD + + + MOD:01062 + carboxymethyl cysteinyl + + OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 + + 197 + DeltaMass + + + From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179 + + Carboxymethyl Cystenyl + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 7 N 3 O 1 S 1 + + + + MassAvg + 157.19 + + + + MassMono + 157.030983 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01063 + monomethylated phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine. + + 198 + DeltaMass + + + From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG]. + PSI-MOD-slim + + NMePhe + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 10 H 11 N 1 O 1 + + + + MassAvg + 161.20 + + + + MassMono + 161.084064 + + + + Origin + F + + + + Source + none + + + + TermSpec + none + + MOD:00599 + MOD:00717 + PSI-MOD + + + MOD:01064 + inositol + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 162 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01065 + hexose glycated N-terminal + + A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine (or aminoketose) residue adduct. + + 0 + DeltaMass + + + 41#N-term + UniMod + + + From DeltaMass: Average Mass: 162 + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + N-term + + MOD:00767 + PSI-MOD + + + MOD:01066 + halogenated phenylalanine + + A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom. + + 18688235 + PubMed + + + + HalPhe + PSI-MOD-label + + + + Origin + F + + + + Source + none + + + + TermSpec + none + + MOD:00694 + MOD:00914 + PSI-MOD + + + MOD:01067 + linker attached to peptide in Fmoc peptide synthesis + + modification from DeltaMass + + 341 + DeltaMass + + + From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01068 + halogenated tryptophan + + A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom. + + 18688235 + PubMed + + + + HalTrp + PSI-MOD-label + + + + Origin + W + + + + Source + none + + + + TermSpec + none + + MOD:00694 + MOD:00918 + PSI-MOD + + + MOD:01069 + 2,4-dinitrophenyl modified residue + + A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Dnp + DeltaMass-label + + + + DiffAvg + 166.09 + + + + DiffFormula + C 6 H 2 N 2 O 4 + + + + DiffMono + 166.001457 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01070 + pentafluorophenyl modified residue + + A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom. + + 0 + DeltaMass + + + From DeltaMass: name mispelled "pentaflourophenyl" + + Pfp + DeltaMass-label + + + + DiffAvg + 166.05 + + + + DiffFormula + C 6 F 5 H -1 + + + + DiffMono + 165.984191 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01071 + diphenylmethyl modified residue + + A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Dpm + DeltaMass-label + + + + DiffAvg + 166.22 + + + + DiffFormula + C 13 H 10 + + + + DiffMono + 166.078250 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01072 + monopotassium salt + + A protein modification that effectively substitutes one potassium atom for one hydrogen atom. + + 0 + DeltaMass + + + PSI-MOD-slim + + K1Res + PSI-MOD-label + + + + DiffAvg + 38.09 + + + + DiffFormula + H -1 K 1 + + + + DiffMono + 37.955882 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00849 + PSI-MOD + + + MOD:01073 + 2-chlorobenzyloxycarbonyl modified residue + + A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Clz + DeltaMass-label + + + + DiffAvg + 169.58 + + + + DiffFormula + C 8 Cl 1 H 6 O 2 + + + + DiffMono + 169.005632 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01074 + napthylacetyl modified residue + + A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom. + + 0 + DeltaMass + + + + + DiffAvg + 169.20 + + + + DiffFormula + C 12 H 9 O 1 + + + + DiffMono + 169.065340 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01075 + mercury containing modified residue + + A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion. + + 18688235 + PubMed + + + + HgRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:01076 + N-methyl arginyl + + modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414. + + 215 + DeltaMass + + + From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 7 H 14 N 4 O 1 + + + + MassAvg + 170.22 + + + + MassMono + 170.116761 + + + + Origin + R + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01077 + ethanedithiol/TFA cyclic adduct + + modification from DeltaMass + + 216 + DeltaMass + + + From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997) + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01078 + S-(2-aminoethyl)-3-methylcysteine (Thr) + + A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine. + + 12923550 + PubMed + + + 472#T + UniMod + + + From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. + + 2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid + PSI-MOD-alternate + + + AEC-MAEC + UniMod-interim + + + beta-methylaminoethylcysteine + UniMod-description + + + S-aminoethyl-3-methylcysteine + PSI-MOD-alternate + + + + DiffAvg + 59.13 + + + + DiffFormula + C 2 H 5 N 1 O -1 S 1 + + + + DiffMono + 59.019356 + + + + Formula + C 6 H 12 N 2 O 1 S 1 + + + + MassAvg + 160.24 + + + + MassMono + 160.067034 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + PSI-MOD + + + MOD:01079 + S-(acetylamino)methyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine. + + 218 + DeltaMass + + + 8572278 + PubMed + + + From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG]. + + Acetamidomethyl Cystenyl + DeltaMass-label + + + Acm-Cys + PSI-MOD-alternate + + + N-(hydroxymethyl)acetamide derivatized L-cysteine + PSI-MOD-alternate + + + S-(acetamido)methyl-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + 71.08 + + + + DiffFormula + C 3 H 5 N 1 O 1 S 0 + + + + DiffMono + 71.037114 + + + + Formula + C 6 H 10 N 2 O 2 S 1 + + + + MassAvg + 174.22 + + + + MassMono + 174.046299 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:01080 + acrylamidyl cysteinyl + + modification from DeltaMass + + 219 + DeltaMass + + + From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221 + + Acrylamidyl Cystenyl + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 10 N 2 O 2 S 1 + + + + MassAvg + 174.22 + + + + MassMono + 174.046299 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01081 + delta-glycosyloxy- (of lysine) or beta-glycosyloxy- (of phenylalanine or tyrosine) + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 177. CAUTION - mass does not match formula. + + + DiffAvg + 178.14 + + + + DiffFormula + C 6 H 10 O 6 + + + + DiffMono + 178.047738 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01082 + 4-glycosyloxy- (hexosyl, C6) (of proline) + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose. + + + DiffAvg + 178.14 + + + + DiffFormula + C 6 H 10 O 6 + + + + DiffMono + 178.047738 + + + + Formula + C 11 H 17 N 1 O 6 + + + + MassAvg + 259.26 + + + + MassMono + 259.105587 + + + + Origin + P + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01083 + O-benzyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine. + + 0 + DeltaMass + + + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + C 10 H 11 N 1 O 2 + + + + MassAvg + 177.20 + + + + MassMono + 177.078979 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01008 + PSI-MOD + + + MOD:01084 + iodoacetic acid derivatized amino-terminal residue + + A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group. + + 6#N-term + UniMod + + + PSI-MOD-slim + + Carboxymethyl + PSI-MS-label + + + Carboxymethyl (on Cysteine) + DeltaMass-label + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00399 + PSI-MOD + + + MOD:01085 + alpha-N-gluconoylation (His Tagged proteins) + + modification from DeltaMass + + 226 + DeltaMass + + + From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01086 + p-nitrobenzyloxycarbonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 179 + + 4Nz + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01087 + 2,4,5-trichlorophenyl modified residue + + A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom. + + 0 + DeltaMass + + + + + DiffAvg + 179.42 + + + + DiffFormula + C 6 Cl 3 H 1 + + + + DiffMono + 177.914383 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01088 + 2,4,6-trimethyloxybenzyl modified residue + + A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom. + + 0 + DeltaMass + + + + Tmob + DeltaMass-label + + + + DiffAvg + 180.20 + + + + DiffFormula + C 10 H 12 O 3 + + + + DiffMono + 180.078644 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01089 + xanthyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 180 + + Xan + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01090 + iodoacetamide derivatized amino-terminal residue + + A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group. + + 11327326 + PubMed + + + 11510821 + PubMed + + + 12422359 + PubMed + + + 4#N-term + UniMod + + + PSI-MOD-slim + + (carbamoylmethyl)amino + PSI-MOD-alternate + + + Carbamidomethyl + PSI-MS-label + + + Iodoacetamide derivative + UniMod-description + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00397 + PSI-MOD + + + MOD:01091 + monochlorinated L-phenylalanine + + A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom. + + 233 + DeltaMass + + + From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623 + + Cl1Phe + PSI-MOD-label + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 9 Cl 1 H 8 N 1 O 1 + + + + MassAvg + 181.62 + + + + MassMono + 181.029442 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:01066 + MOD:01911 + PSI-MOD + + + MOD:01092 + mesitylene-2-sulfonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 182 + + Mts + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01093 + isopropyl lysyl + + modification from DeltaMass + + 236 + DeltaMass + + + From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 9 H 16 N 2 O 2 + + + + MassAvg + 184.24 + + + + MassMono + 184.121178 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01094 + N6-carboxymethyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine. + + 237 + DeltaMass + + + 6#K + UniMod + + + From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG]. + PSI-MOD-slim + + Carboxymethyl + PSI-MS-label + + + Carboxymethyl Lysyl + DeltaMass-label + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + C 8 H 14 N 2 O 3 + + + + MassAvg + 186.21 + + + + MassMono + 186.100442 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00399 + PSI-MOD + + + MOD:01095 + Matrix alpha cyano MH+ + + Modification from DeltaMass. OBSOLETE because not an amino acid modification. + + 240 + DeltaMass + + + From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 10 H 8 N 1 O 3 + + + + MassAvg + 190.18 + + + + MassMono + 190.050418 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01096 + O-benzyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine. + + 0 + DeltaMass + + + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + C 11 H 13 N 1 O 2 + + + + MassAvg + 191.23 + + + + MassMono + 191.094629 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01008 + PSI-MOD + + + MOD:01097 + S-benzyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine. + + 242 + DeltaMass + + + From DeltaMass: misspelled "Benzyl Cystenyl". + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + C 10 H 11 N 1 O 1 S 1 + + + + MassAvg + 193.26 + + + + MassMono + 193.056135 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + MOD:01008 + PSI-MOD + + + MOD:01098 + naphthylalanine residue + + A protein modification that inserts or replaces a residue with a naphthylalanine. + + 243 + DeltaMass + + + From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG]. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 13 H 11 N 1 O 1 + + + + MassAvg + 197.24 + + + + MassMono + 197.084064 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00850 + PSI-MOD + + + MOD:01099 + succinyl beta-aspartyl anhydride + + A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride. + + 244 + DeltaMass + + + From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG]. + + succinyl aspartamyl + DeltaMass-label + + + + DiffAvg + 82.06 + + + + DiffFormula + C 4 H 2 N 0 O 2 + + + + DiffMono + 82.005479 + + + + Formula + C 8 H 8 N 1 O 5 + + + + MassAvg + 198.15 + + + + MassMono + 198.040247 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00904 + MOD:01029 + PSI-MOD + + + MOD:01100 + HMP (hydroxymethylphenyl)/TFA adduct + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 201 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01101 + S-Farnesyl- + + OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111. + + 0 + DeltaMass + + + Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01102 + myristoylation-4H (two double bonds) + + OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504. + + 348 + DeltaMass + + + From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds) + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01103 + myristoleylation (one double bond) + + OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503. + + 0 + DeltaMass + + + From DeltaMass with no citation or formula: Average Mass: 208. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01104 + 4-methoxy-2,3,6-trimethylbenzenesulfonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 212 with no citation. + + Mtr + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01105 + 2-bromobenzyloxycarbonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 213 with no citation. + + BrZ + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01106 + N-formyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan. + + 0 + DeltaMass + + + From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG] + + formyl tryptophanyl + DeltaMass-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 12 H 10 N 2 O 2 + + + + MassAvg + 214.22 + + + + MassMono + 214.074228 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00409 + MOD:00918 + PSI-MOD + + + MOD:01107 + O5-benzyl-L-glutamate + + A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate. + + 258 + DeltaMass + + + From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + C 12 H 13 N 1 O 3 + + + + MassAvg + 219.24 + + + + MassMono + 219.089543 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00906 + MOD:01008 + PSI-MOD + + + MOD:01108 + 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu) + + A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct. + + 259 + DeltaMass + + + From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. + + anisole adducted glutamyl + DeltaMass-label + + + + DiffAvg + 90.13 + + + + DiffFormula + C 7 H 6 + + + + DiffMono + 90.046950 + + + + Formula + C 12 H 13 N 1 O 3 + + + + MassAvg + 219.24 + + + + MassMono + 219.089543 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00906 + MOD:01007 + PSI-MOD + + + MOD:01109 + 9-fluorenylmethyloxycarbonyl (Fmoc) + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 222 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01110 + isoprenylated cysteine + + A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). + + 18688235 + PubMed + + + PSI-MOD-slim + + IpCys + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + none + + + + TermSpec + none + + MOD:00703 + MOD:00905 + PSI-MOD + + + MOD:01111 + dimethoxybenzhydryl modified residue + + A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG]. + + 4,4'-dimethoxybenzhydryl + PSI-MOD-alternate + + + bis(4-methoxyphenyl)methyl + PSI-MOD-alternate + + + Mbh + DeltaMass-label + + + + DiffAvg + 226.27 + + + + DiffFormula + C 15 H 14 O 2 + + + + DiffMono + 226.099380 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01112 + nicotinoyl lysine + + modification from DeltaMass + + 266 + DeltaMass + + + From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271 + + nicotinyl lysyl + DeltaMass-label + + + + DiffAvg + 105.10 + + + + DiffFormula + C 6 H 3 N 1 O 1 + + + + DiffMono + 105.021464 + + + + Formula + C 12 H 15 N 3 O 2 + + + + MassAvg + 233.27 + + + + MassMono + 233.116427 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01113 + 2-(p-biphenyl)isopropyl-oxycarbonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 238 with no citation. + + Bpoc + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01114 + triphenylmethyl + + modification from DeltaMass + + 270 + DeltaMass + + + From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N + + Trityl + DeltaMass-label + + + Trt + DeltaMass-label + + + + DiffAvg + 242.32 + + + + DiffFormula + C 19 H 14 + + + + DiffMono + 242.109550 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01115 + isoprenylated tryptophan + + A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). + + 18688235 + PubMed + + + + IpTrp + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + W + + + + Source + none + + + + TermSpec + none + + MOD:00703 + MOD:00918 + PSI-MOD + + + MOD:01116 + S-farnesyl-L-cysteine methyl ester + + A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester. + + 15609361 + PubMed + + + AA0102#var + RESID + + + AA0105#var + RESID + + + PSI-MOD-slim + + SFarnOMeCys + PSI-MOD-label + + + + DiffAvg + 218.38 + + + + DiffFormula + C 16 H 26 N 0 O 0 S 0 + + + + DiffMono + 218.203451 + + + + Formula + C 19 H 32 N 1 O 2 S 1 + + + + MassAvg + 338.53 + + + + MassMono + 338.215375 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:00905 + + has_functional_parent + MOD:001110 + + + has_functional_parent + MOD:001140 + + PSI-MOD + + + MOD:01117 + pentamethyldihydrobenzofuransulfonyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 252 with no citation. + + Pbf + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01118 + alpha-N-6-phosphogluconoylation (His Tagged proteins) + + modification from DeltaMass + + 275 + DeltaMass + + + From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01119 + S-geranylgeranyl-L-cysteine methyl ester + + A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester. + + 1483450 + PubMed + + + 15609361 + PubMed + + + AA0104#var + RESID + + + AA0105#var + RESID + + + PSI-MOD-slim + + SGergerOMeCys + PSI-MOD-label + + + + DiffAvg + 286.50 + + + + DiffFormula + C 21 H 34 N 0 O 0 S 0 + + + + DiffMono + 286.266051 + + + + Formula + C 24 H 40 N 1 O 2 S 1 + + + + MassAvg + 406.65 + + + + MassMono + 406.277976 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:00905 + + has_functional_parent + MOD:001130 + + + has_functional_parent + MOD:001140 + + PSI-MOD + + + MOD:01120 + 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue + + A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG]. + + 2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl + PSI-MOD-alternate + + + 2,2,5,7,8-pentamethyl-6-chromansulfonyl + PSI-MOD-alternate + + + 2,2,5,7,8-pentamethyl-chromane-6-sulfonyl + PSI-MOD-alternate + + + 2,2,5,7,8-pentamethylchroman-6-sulfonyl + PSI-MOD-alternate + + + 2,2,5,7,8-pentamethylchroman-6-sulphonyl + PSI-MOD-alternate + + + 3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl + PSI-MOD-alternate + + + Pmc + DeltaMass-label + + + PmcRes + PSI-MOD-label + + + + DiffAvg + 266.36 + + + + DiffFormula + C 14 H 18 O 3 S 1 + + + + DiffMono + 266.097665 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01652 + PSI-MOD + + + MOD:01121 + monomethoxytrityl + + modification from DeltaMass + + 280 + DeltaMass + + + From DeltaMass: Average Mass: 272 Average Mass Change: 272 + + Mmt + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01122 + 5'phos dCytidinyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 289 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01123 + monoiodated tyrosine + + OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 289 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01124 + aldohexosyl lysyl + + modification from DeltaMass + + 285 + DeltaMass + + + From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317 + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 N 0 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 12 H 22 N 2 O 6 + + + + MassAvg + 290.32 + + + + MassMono + 290.147786 + + + + Origin + K + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01125 + 5'phos dThymidinyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 304 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01126 + 5'phos Cytidinyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 305 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01127 + 5'phos Uridinyl + + OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166. + + 292 + DeltaMass + + + From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01128 + N-glycolneuraminic acid + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 307 with no citation. + + NeuGc + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01129 + 5'phos dAdenosyl + + modification from DeltaMass + + 295 + DeltaMass + + + From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01130 + SucPhencarb Lysyl + + modification from DeltaMass + + 297 + DeltaMass + + + From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01131 + 5'phos dGuanosyl + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 329 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01132 + 5'phos Adenosinyl + + OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 329 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01133 + S-12-hydroxyfarnesyl-L-cysteine methyl ester + + A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester. + + 17790543 + PubMed + + + AA0103#var + RESID + + + AA0105#var + RESID + + + + S12HyFarnOMeCys + PSI-MOD-label + + + + DiffAvg + 234.38 + + + + DiffFormula + C 16 H 26 N 0 O 1 S 0 + + + + DiffMono + 234.198365 + + + + Formula + C 19 H 32 N 1 O 3 S 1 + + + + MassAvg + 354.53 + + + + MassMono + 354.210290 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:00905 + + has_functional_parent + MOD:001120 + + + has_functional_parent + MOD:001140 + + PSI-MOD + + + MOD:01134 + fluorescein labelling of peptide N-terminal using NHS ester + + modification from DeltaMass + + 306 + DeltaMass + + + From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01135 + Hex-HexNAc + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 365 with no citation. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01136 + dioctyl phthalate + + modification from DeltaMass + + 309 + DeltaMass + + + From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01137 + N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine + + A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine. + + 310 + DeltaMass + + + From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534 + + PMC lysyl + DeltaMass-label + + + PmcLys + PSI-MOD-label + + + + DiffAvg + 266.36 + + + + DiffFormula + C 14 H 18 O 3 S 1 + + + + DiffMono + 266.097665 + + + + Formula + C 20 H 30 N 2 O 4 S 1 + + + + MassAvg + 394.53 + + + + MassMono + 394.192628 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00902 + MOD:01120 + PSI-MOD + + + MOD:01138 + Aedans Cystenyl + + modification from DeltaMass + + 311 + DeltaMass + + + [probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01139 + dioctyl phthalate sodium adduct + + modification from DeltaMass + + 312 + DeltaMass + + + From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + artifact + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01140 + diiodinated tyrosine + + A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms. + + 0 + DeltaMass + + + 15627961 + PubMed + + + 130#Y + UniMod + + + PSI-MOD-slim + + 3,5-Diiodination (of Tyrosine) + DeltaMass-label + + + di-Iodination + UniMod-description + + + diiodinationy + OMSSA-label + + + Diiodo + PSI-MS-label + + + I2Tyr + PSI-MOD-label + + + + DiffAvg + 251.79 + + + + DiffFormula + C 0 H -2 I 2 N 0 O 0 + + + + DiffMono + 251.793295 + + + + Formula + C 9 H 7 I 2 N 1 O 2 + + + + MassAvg + 414.97 + + + + MassMono + 414.856624 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00501 + MOD:00998 + PSI-MOD + + + MOD:01141 + omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine + + A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine. + + 314 + DeltaMass + + + From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547 + + PMC arginyl + DeltaMass-label + + + PmcArg + PSI-MOD-label + + + + DiffAvg + 266.36 + + + + DiffFormula + C 14 H 18 O 3 S 1 + + + + DiffMono + 266.097665 + + + + Formula + C 20 H 30 N 4 O 4 S 1 + + + + MassAvg + 422.54 + + + + MassMono + 422.198776 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00902 + MOD:01120 + PSI-MOD + + + MOD:01142 + S-15,16-dihydrobiliverdin-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin. + + 10430868 + PubMed + + + 15504407 + PubMed + + + 1559975 + PubMed + + + 3208761 + PubMed + + + AA0428 + RESID + + + + (16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione + RESID-systematic + + + 15,16-Dhbv + RESID-alternate + + + 15,16-dihydrobiliverdin cysteine adduct + RESID-alternate + + + 15,16-dihydrobiliverdin IXalpha + RESID-alternate + + + 18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione + RESID-alternate + + + 3'-cysteinyl-15,16-dihydrobiliverdin + RESID-alternate + + + 3alpha-cysteinyl-15,16-dihydrobiliverdin + RESID-alternate + + + BINDING 15,16-dihydrobiliverdin (covalent; via 1 link) + UniProt-feature + + + DBV + RESID-alternate + + + S-15,16-dihydrobiliverdin-L-cysteine + RESID-name + + + + DiffAvg + 584.67 + + + + DiffFormula + C 33 H 36 N 4 O 6 S 0 + + + + DiffMono + 584.263485 + + + + Formula + C 36 H 41 N 5 O 7 S 1 + + + + MassAvg + 687.81 + + + + MassMono + 687.272670 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:01143 + 15,16-dihydrobiliverdin-bis-L-cysteine + + A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin. + + 1559975 + PubMed + + + 2222853 + PubMed + + + 3208761 + PubMed + + + 8420941 + PubMed + + + AA0429 + RESID + + + Cross-link 2. + + (16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione + RESID-systematic + + + 15,16-Dhbv + RESID-alternate + + + 15,16-dihydrobiliverdin cysteine adduct + RESID-alternate + + + 15,16-dihydrobiliverdin IXalpha + RESID-alternate + + + 15,16-dihydrobiliverdin-bis-L-cysteine + RESID-name + + + 3'',18'-biscysteinyl-15,16-dihydrobiliverdin + RESID-alternate + + + 3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin + RESID-alternate + + + 8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione + RESID-alternate + + + BINDING 15,16-dihydrobiliverdin (covalent; via 2 links) + UniProt-feature + + + DBV + RESID-alternate + + + + DiffAvg + 584.67 + + + + DiffFormula + C 33 H 36 N 4 O 6 S 0 + + + + DiffMono + 584.263485 + + + + Formula + C 39 H 46 N 6 O 8 S 2 + + + + MassAvg + 790.95 + + + + MassMono + 790.281854 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:01144 + S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. + + 0 + DeltaMass + + + 10896212 + PubMed + + + 4575979 + PubMed + + + 9056182 + PubMed + + + AA0107#var + RESID + + + From DeltaMass: Average Mass: 524 + PSI-MOD-slim + + S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine) + DeltaMass-label + + + + DiffAvg + 550.91 + + + + DiffFormula + C 35 H 66 N 0 O 4 S 0 + + + + DiffMono + 550.496111 + + + + Formula + C 38 H 71 N 1 O 5 S 1 + + + + MassAvg + 654.05 + + + + MassMono + 653.505295 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00116 + PSI-MOD + + + MOD:01145 + N-tau-(ADP-ribosyl)diphthamide + + A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide. + + 0 + DeltaMass + + + From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648 + + + DiffAvg + 684.51 + + + + DiffFormula + C 22 H 36 N 7 O 14 P 2 + + + + DiffMono + 684.178999 + + + + FormalCharge + 1+ + + + + Formula + C 28 H 43 N 10 O 15 P 2 + + + + MassAvg + 821.65 + + + + MassMono + 821.237910 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00909 + + derives_from + MOD:000490 + + PSI-MOD + + + MOD:01146 + S-(6-FAD)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine. + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 784 with no citation. This modification has not been reported [JSG]. + PSI-MOD-slim + + FAD + PSI-MS-label + + + S6FADCys + PSI-MOD-label + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 S 0 + + + + DiffMono + 783.141485 + + + + Formula + C 30 H 36 N 10 O 16 P 2 S 1 + + + + MassAvg + 886.68 + + + + MassMono + 886.150669 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00895 + MOD:00905 + PSI-MOD + + + MOD:01147 + (Hex)3-HexNAc-(dHex)HexNAc + + modification from DeltaMass + + 0 + DeltaMass + + + From DeltaMass: Average Mass: 1,039 + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + none + + + + TermSpec + none + + MOD:00947 + PSI-MOD + + + MOD:01148 + ubiquitinylated lysine + + A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin. + + 11125103 + PubMed + + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:01875 + + contains + MOD:001340 + + PSI-MOD + + + MOD:01149 + sumoylated lysine + + A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein. + + 12612601 + PubMed + + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:01875 + + contains + MOD:001340 + + PSI-MOD + + + MOD:01150 + neddylated lysine + + A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein. + + 11125103 + PubMed + + + 12612601 + PubMed + + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:01875 + + contains + MOD:001340 + + PSI-MOD + + + MOD:01151 + phosphorylated residue with neutral loss of phosphate + + Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + -97.99 + + + + DiffFormula + C 0 H -3 N 0 O -4 P -1 + + + + DiffMono + -97.976895 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00432 + PSI-MOD + + + MOD:01152 + carboxylated residue + + A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group. + + 299 + UniMod + + + PSI-MOD-slim + + Carboxy + UniMod-interim + + + Carboxylation + UniMod-description + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 + + + + DiffMono + 43.989829 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:01153 + methylthiolated residue + + A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group). + + 39 + UniMod + + + PSI-MOD-slim + + Beta-methylthiolation + UniMod-description + + + Methylthio + UniMod-interim + + + + DiffAvg + 46.09 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 1 + + + + DiffMono + 45.987721 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01886 + PSI-MOD + + + MOD:01154 + pyruvic acid + + A protein modification that effectively converts a source amino acid to pyruvic acid. + + 10085076 + PubMed + + + 3042771 + PubMed + + + 8464063 + PubMed + + + AA0127 + RESID + + + PSI-MOD-slim + + 2-oxopropanoic acid + RESID-systematic + + + MOD_RES Pyruvic acid (Cys) + UniProt-feature + + + MOD_RES Pyruvic acid (Ser) + UniProt-feature + + + pyruvic acid + RESID-name + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 3 H 3 O 2 + + + + MassAvg + 71.06 + + + + MassMono + 71.013304 + + + + Origin + X + + + + Source + none + + + + TermSpec + N-term + + MOD:00769 + MOD:00859 + PSI-MOD + + + MOD:01155 + lipoconjugated residue + + A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01156 + PSI-MOD + + + MOD:01156 + protein modification categorized by chemical process + + Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00000 + PSI-MOD + + + MOD:01157 + protein modification categorized by amino acid modified + + A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00000 + PSI-MOD + + + MOD:01158 + modified L-selenocysteine residue + + A protein modification that modifies an L-selenocysteine residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + U + + MOD:00745 + MOD:01157 + + derives_from + MOD:000310 + + PSI-MOD + + + MOD:01159 + peptidoglycanated residue + + A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage. + + 18688235 + PubMed + + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00764 + PSI-MOD + + + MOD:01160 + deaminated residue + + A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen. + + 385 + UniMod + + + PSI-MOD-slim + + Ammonia-loss + UniMod-interim + + + Loss of ammonia + UniMod-description + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:01161 + deoxygenated residue + + A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms. + + 14235557 + PubMed + + + 447 + UniMod + + + PSI-MOD-slim + + Deoxy + PSI-MS-label + + + dOxyRes + PSI-MOD-label + + + reduction + UniMod-description + + + + DiffAvg + -16.00 + + + + DiffFormula + C 0 H 0 N 0 O -1 + + + + DiffMono + -15.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01472 + PSI-MOD + + + MOD:01162 + fucosylated biantennary + + modification from UniMod N-linked glycosylation + + 308 + UniMod + + + + dHex(1)Hex(5)HexNAc(4) + PSI-MS-label + + + Fucosylated biantennary + UniMod-description + + + + DiffAvg + 1769.62 + + + + DiffFormula + C 68 H 112 N 4 O 49 + + + + DiffMono + 1768.639516 + + + + Formula + C 72 H 118 N 6 O 51 + + + + MassAvg + 1883.73 + + + + MassMono + 1882.682443 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00725 + PSI-MOD + + + MOD:01163 + guanylated residue + + A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond. + + 304 + DeltaMass + + + 413 + UniMod + + + From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209. + + 5'phos Guanosyl + DeltaMass-label + + + phospho-guanosine + UniMod-description + + + Phosphoguanosine + PSI-MS-label + + + + DiffAvg + 345.21 + + + + DiffFormula + C 10 H 12 N 5 O 7 P 1 + + + + DiffMono + 345.047434 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00701 + PSI-MOD + + + MOD:01164 + riboflavin-phosphoryl + + A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond. + + 442 + UniMod + + + PSI-MOD-slim + + FMN + PSI-MS-label + + + O3-(riboflavin phosphoryl) + UniMod-description + + + + DiffAvg + 438.33 + + + + DiffFormula + C 17 H 19 N 4 O 8 P 1 + + + + DiffMono + 438.094050 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00896 + PSI-MOD + + + MOD:01165 + adenylated residue + + A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond. + + 0 + DeltaMass + + + 405 + UniMod + + + From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329 + PSI-MOD-slim + + 5'phos Adenosinyl + DeltaMass-label + + + AMP binding site + UniMod-description + + + Phosphoadenosine + PSI-MS-label + + + + DiffAvg + 329.21 + + + + DiffFormula + C 10 H 12 N 5 O 6 P 1 + + + + DiffMono + 329.052520 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00701 + PSI-MOD + + + MOD:01166 + uridylated residue + + A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond. + + 292 + DeltaMass + + + 417 + UniMod + + + From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 + + 5'phos Uridinyl + DeltaMass-label + + + PhosphoUridine + PSI-MS-label + + + uridine phosphodiester + UniMod-description + + + + DiffAvg + 306.17 + + + + DiffFormula + C 9 H 11 N 2 O 8 P 1 + + + + DiffMono + 306.025302 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00701 + PSI-MOD + + + MOD:01167 + molybdopterin guanine dinucleotide + + modification from UniMod + + 424 + UniMod + + + + molybdenum bis(molybdopterin guanine dinucleotide) + UniMod-description + + + MolybdopterinGD + PSI-MS-label + + + + DiffAvg + 1572.02 + + + + DiffFormula + C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 + + + + DiffMono + 1572.985775 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00744 + PSI-MOD + + + MOD:01168 + dehydroalanine + + A protein modification that effectively converts a source amino acid residue to dehydroalanine. + + 10220322 + PubMed + + + 1547888 + PubMed + + + 1815586 + PubMed + + + 2914619 + PubMed + + + 6838602 + PubMed + + + 7947813 + PubMed + + + 8239649 + PubMed + + + AA0181 + RESID + + + PSI-MOD-slim + + 2,3-didehydroalanine + RESID-alternate + + + 2-aminoacrylic acid + RESID-alternate + + + 2-aminopropenoic acid + RESID-systematic + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + anhydroserine + RESID-alternate + + + dehydroalanine + RESID-name + + + Dha + RESID-alternate + + + dHAla + PSI-MOD-label + + + MOD_RES 2,3-didehydroalanine (Cys) + UniProt-feature + + + MOD_RES 2,3-didehydroalanine (Ser) + UniProt-feature + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 3 H 3 N 1 O 1 + + + + MassAvg + 69.06 + + + + MassMono + 69.021464 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + PSI-MOD + + + MOD:01169 + L-3-oxoalanine + + A protein modification that effectively converts a source amino acid residue to L-oxoalanine. + + 349 + DeltaMass + + + 14563551 + PubMed + + + 7628016 + PubMed + + + 8681943 + PubMed + + + 9478923 + PubMed + + + AA0185 + RESID + + + PSI-MOD-slim + + (S)-2-amino-3-oxopropanoic acid + RESID-systematic + + + 2-amino-3-oxopropionic acid + RESID-alternate + + + C(alpha)-formylglycine + RESID-misnomer + + + L-3-oxoalanine + RESID-name + + + L-amino-malonic acid semialdehyde + RESID-alternate + + + L-aminomalonaldehydic acid + RESID-alternate + + + L-serinesemialdehyde + RESID-misnomer + + + MOD_RES 3-oxoalanine (Cys) + UniProt-feature + + + MOD_RES 3-oxoalanine (Ser) + UniProt-feature + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 3 H 3 N 1 O 2 + + + + MassAvg + 85.06 + + + + MassMono + 85.016378 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + PSI-MOD + + + MOD:01170 + pyruvic acid iminylated residue + + A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group. + + 422 + UniMod + + + + N-pyruvic acid 2-iminyl + UniMod-description + + + PyruvicAcidIminyl + PSI-MS-label + + + + DiffAvg + 70.05 + + + + DiffFormula + C 3 H 2 N 0 O 2 + + + + DiffMono + 70.005479 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + N-term + + MOD:01156 + PSI-MOD + + + MOD:01171 + O-acetyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine. + + 16728640 + PubMed + + + AA0423 + RESID + + + 1#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-3-(acetyloxy)-2-aminobutanoic acid + RESID-systematic + + + Acetylation + UniMod-description + + + ACT_SITE O-acetylthreonine intermediate + UniProt-feature + + + MOD_RES O-acetylthreonine + UniProt-feature + + + O-acetyl-L-threonine + RESID-name + + + O-acetylthreonine + RESID-alternate + + + OAcThr + PSI-MOD-label + + + threonine acetate ester + RESID-alternate + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + C 6 H 9 N 1 O 3 + + + + MassAvg + 143.14 + + + + MassMono + 143.058243 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00644 + MOD:01186 + PSI-MOD + + + MOD:01172 + N-alanyl-glycosylsphingolipidinositolethanolamine + + A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine. + + 12626404 + PubMed + + + AA0424 + RESID + + + + GSIAla + PSI-MOD-label + + + LIPID GPI-like-anchor amidated alanine + UniProt-feature + + + N-alanyl-glycosylsphingolipidinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 5 H 12 N 2 O 5 P 1 + + + + MassAvg + 211.13 + + + + MassMono + 211.048383 + + + + Origin + A + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00466 + MOD:00901 + PSI-MOD + + + MOD:01173 + N-asparaginyl-glycosylsphingolipidinositolethanolamine + + A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine. + + 12626404 + PubMed + + + AA0425 + RESID + + + + GSIAsn + PSI-MOD-label + + + LIPID GPI-like-anchor amidated asparagine + UniProt-feature + + + N-asparaginyl-glycosylsphingolipidinositolethanolamine + RESID-name + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 6 H 13 N 3 O 6 P 1 + + + + MassAvg + 254.16 + + + + MassMono + 254.054197 + + + + Origin + N + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00466 + MOD:00903 + PSI-MOD + + + MOD:01174 + S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine. + + 27485 + ChEBI + + + 11466314 + PubMed + + + 12684535 + PubMed + + + AA0426 + RESID + + + + (2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid + RESID-alternate + + + (5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid + RESID-systematic + + + LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine + UniProt-feature + + + PG-J2Cys + PSI-MOD-label + + + S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine + RESID-name + + + + DiffAvg + 316.44 + + + + DiffFormula + C 20 H 28 N 0 O 3 S 0 + + + + DiffMono + 316.203845 + + + + Formula + C 23 H 33 N 1 O 4 S 1 + + + + MassAvg + 419.58 + + + + MassMono + 419.213030 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01155 + PSI-MOD + + + MOD:01175 + S-phycourobilin-L-cysteine + + A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin. + + 1903388 + PubMed + + + 3208761 + PubMed + + + 3838747 + PubMed + + + AA0427 + RESID + + + + (2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione + RESID-systematic + + + 18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid + RESID-alternate + + + BINDING Phycourobilin chromophore (covalent; via 1 link) + UniProt-feature + + + phycourobilin cysteine adduct + RESID-alternate + + + PUB + RESID-alternate + + + PUBCys + PSI-MOD-label + + + S-phycourobilin-L-cysteine + RESID-name + + + + DiffAvg + 586.69 + + + + DiffFormula + C 33 H 38 N 4 O 6 S 0 + + + + DiffMono + 586.279135 + + + + Formula + C 36 H 43 N 5 O 7 S 1 + + + + MassAvg + 689.83 + + + + MassMono + 689.288320 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00700 + MOD:00905 + PSI-MOD + + + MOD:01176 + L-dehydrolysinonorleucine + + A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine. + + 16929109 + PubMed + + + AA0430 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid + RESID-systematic + + + 6-(N6-L-didehydrolysino)-L-norleucine + RESID-alternate + + + CROSSLNK Dehydrolysinonorleucine (Lys-Lys) + UniProt-feature + + + dehydrolysinorleucine [misspelling] + RESID-alternate + + + dehydrolysylnorleucine + RESID-alternate + + + didehydrolysinonorleucine + RESID-alternate + + + L-dehydrolysinonorleucine + RESID-name + + + N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine + RESID-alternate + + + XLNK6NleN6Lys + PSI-MOD-label + + + + DiffAvg + -19.05 + + + + DiffFormula + C 0 H -5 N -1 O 0 + + + + DiffMono + -19.042199 + + + + Formula + C 12 H 19 N 3 O 2 + + + + MassAvg + 237.30 + + + + MassMono + 237.147727 + + + + Origin + K, K + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00912 + PSI-MOD + + + MOD:01177 + 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine + + A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine. + + 16760471 + PubMed + + + AA0431 + RESID + + + + (S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid + RESID-systematic + + + 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine + RESID-name + + + 1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine + RESID-alternate + + + MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine + UniProt-feature + + + N(epsilon)-histidine dihydroxyacetone adduct + RESID-alternate + + + N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine + RESID-alternate + + + NtauDHAHis + PSI-MOD-label + + + tele-(1,2,3-trihydroxypropan-2-yl)histidine + RESID-alternate + + + + DiffAvg + 90.08 + + + + DiffFormula + C 3 H 6 N 0 O 3 + + + + DiffMono + 90.031694 + + + + Formula + C 9 H 13 N 3 O 4 + + + + MassAvg + 227.22 + + + + MassMono + 227.090606 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + PSI-MOD + + + MOD:01178 + S-(aspart-4-yloxy) thiocarbonate + + A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate. + + 16627948 + PubMed + + + AA0432 + RESID + + + This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. + + (2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid + RESID-systematic + + + 4-aspartyloxysulfanylcarbonate + RESID-alternate + + + AspOSCO2H + PSI-MOD-label + + + O-carboxysulfanyl-4-oxo-L-homoserine + RESID-alternate + + + S-(aspart-4-yloxy) thiocarbonate + RESID-name + + + + DiffAvg + 76.07 + + + + DiffFormula + C 1 H 0 N 0 O 2 S 1 + + + + DiffMono + 75.961900 + + + + Formula + C 5 H 5 N 1 O 5 S 1 + + + + MassAvg + 191.16 + + + + MassMono + 190.988843 + + + + Origin + D + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00904 + PSI-MOD + + + MOD:01179 + N,N-dimethyl-L-alanine + + A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine. + + 17691833 + PubMed + + + 387091 + PubMed + + + AA0433 + RESID + + + + (S)-1-carboxy-N,N-dimethylaminoethane + RESID-alternate + + + (S)-2-(dimethylamino)propanoic acid + RESID-systematic + + + MOD_RES N,N-dimethylalanine + UniProt-feature + + + N,N-dimethyl-L-alanine + RESID-name + + + N,N-dimethylalanine + RESID-alternate + + + NMe2Ala + PSI-MOD-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 5 H 10 N 1 O 1 + + + + MassAvg + 100.14 + + + + MassMono + 100.076239 + + + + Origin + A + + + + Source + natural + + + + TermSpec + N-term + + MOD:01461 + MOD:01686 + PSI-MOD + + + MOD:01180 + 2-hydroxyglycine observational artifact + + A protein modification that effectively converts a glycine residue to 2-hydroxyglycine. + + 38048 + ChEBI + + + 16178056 + PubMed + + + 17431180 + PubMed + + + 17823333 + PubMed + + + AA0434 + RESID + + + CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG]. + + 2-hydroxyglycine + RESID-name + + + 2HyGly + PSI-MOD-label + + + alpha-hydroxyglycine + RESID-alternate + + + amino(hydroxy)acetic acid + RESID-systematic + + + aminohydroxyacetic acid + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 2 H 3 N 1 O 2 + + + + MassAvg + 73.05 + + + + MassMono + 73.016378 + + + + Origin + G + + + + Source + artifact + + + + TermSpec + none + + MOD:00425 + MOD:00908 + PSI-MOD + + + MOD:01181 + L-aspartic acid 4-methyl ester + + A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester. + + 1556110 + PubMed + + + 16888766 + PubMed + + + 9629898 + PubMed + + + AA0435 + RESID + + + 34#D + UniMod + + + CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG]. + + (2S)-2-amino-4-methoxy-4-oxobutanoic acid + RESID-systematic + + + 2-aminobutanedioic acid 4-methyl ester + RESID-alternate + + + 4-methyl L-2-aminosuccinic acid + RESID-alternate + + + 4-methyl L-aspartate + RESID-alternate + + + 4-methyl L-hydrogen aspartate + RESID-alternate + + + aspartic acid 4-methyl ester + RESID-alternate + + + aspartic acid beta-methyl ester + RESID-alternate + + + L-aspartic acid 4-methyl ester + RESID-name + + + meesterd + OMSSA-label + + + Methyl + PSI-MS-label + + + O4MeAsp + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00393 + MOD:01681 + PSI-MOD + + + MOD:01182 + 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD + + A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD. + + + PubMed + + + AA0436 + RESID + + + Cross-link 2. + PSI-MOD-slim + + 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine + RESID-systematic + + + 6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD + RESID-alternate + + + 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD + RESID-alternate + + + 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD + RESID-alternate + + + 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD + RESID-alternate + + + 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD + RESID-name + + + BINDING FAD (covalent; via 2 links) + UniProt-feature + + + BINDING FAD (covalent; via 2 links, pros nitrogen) + UniProt-feature + + + SCys6-NprosHis8a-FAD + PSI-MOD-label + + + + DiffAvg + 781.52 + + + + DiffFormula + C 27 H 29 N 9 O 15 P 2 S 0 + + + + DiffMono + 781.125835 + + + + Formula + C 36 H 41 N 13 O 17 P 2 S 1 + + + + MassAvg + 1021.81 + + + + MassMono + 1021.193931 + + + + Origin + C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00895 + MOD:00905 + MOD:00909 + MOD:01621 + PSI-MOD + + + MOD:01183 + L-selenocystine (oxidized selenocysteine) (Sec-Sec) + + A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine, + + 28553 + ChEBI + + + 17715293 + PubMed + + + 6076213 + PubMed + + + AA0437 + RESID + + + Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184. + PSI-MOD-slim + + (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) + RESID-systematic + + + 3,3'-diselenobis(2-aminopropanoic acid) + RESID-alternate + + + 3,3'-diselenobisalanine + RESID-alternate + + + 3,3'-diselenodialanine + RESID-alternate + + + beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide + RESID-alternate + + + beta,beta'-diselenodialanine + RESID-alternate + + + bis(alpha-aminopropionic acid)-beta-diselenide + RESID-alternate + + + bis(beta-amino-beta-carboxyethyl)diselenide + RESID-alternate + + + CROSSLNK Selenocystine (Sec-Sec) + UniProt-feature + + + diselenocysteine + RESID-alternate + + + L-selenocystine + RESID-name + + + Sec2 + PSI-MOD-label + + + selenium cystine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 Se 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 2 Se 2 + + + + MassAvg + 298.08 + + + + MassMono + 299.891620 + + + + Origin + U, U + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00692 + MOD:01158 + PSI-MOD + + + MOD:01184 + L-selenocystine (selenium disubstituted L-cystine) + + A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine. + + 17715293 + PubMed + + + AA0437#CYS2 + RESID + + + Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183. + + (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) + RESID-systematic + + + 3,3'-diselenobis(2-aminopropanoic acid) + RESID-alternate + + + 3,3'-diselenobisalanine + RESID-alternate + + + 3,3'-diselenodialanine + RESID-alternate + + + beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide + RESID-alternate + + + beta,beta'-diselenodialanine + RESID-alternate + + + bis(alpha-aminopropionic acid)-beta-diselenide + RESID-alternate + + + bis(beta-amino-beta-carboxyethyl)diselenide + RESID-alternate + + + CROSSLNK Selenocystine (Sec-Sec) + UniProt-feature + + + diselenocysteine + RESID-alternate + + + L-selenocystine + RESID-name + + + Se2(S2)Cys2 + PSI-MOD-label + + + selenium cystine + RESID-alternate + + + + DiffAvg + 91.81 + + + + DiffFormula + C 0 H -2 N 0 O 0 S -2 Se 2 + + + + DiffMono + 93.873250 + + + + Formula + C 6 H 8 N 2 O 2 Se 2 + + + + MassAvg + 298.08 + + + + MassMono + 299.891620 + + + + Origin + C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00007 + MOD:00905 + PSI-MOD + + + MOD:01185 + 4-amidated L-aspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to L-asparagine. + + 17962566 + PubMed + + + AA0003#ASP + RESID + + + + (2S)-2-amino-4-butanediamic acid + RESID-systematic + + + 2,4-bis(azanyl)-4-oxobutanoic acid + RESID-alternate + + + 2,4-diamino-4-oxobutanoic acid + RESID-alternate + + + 2-amino-3-carbamoylpropanoic acid + RESID-alternate + + + 2-amino-4-butanediamic acid + RESID-alternate + + + 2-aminosuccinamic acid + RESID-alternate + + + 2-aminosuccinic acid 4-amide + RESID-alternate + + + 4NAsp + PSI-MOD-label + + + alpha-amino-beta-carbamylpropionic acid + RESID-alternate + + + alpha-aminosuccinamic acid + RESID-alternate + + + aspartic acid 4-amide + RESID-alternate + + + aspartic acid beta-amide + RESID-alternate + + + beta-asparagine + RESID-alternate + + + L-asparagine + RESID-name + + + MOD_RES Amidated aspartic acid + UniProt-feature + + + + DiffAvg + -0.98 + + + + DiffFormula + C 0 H 1 N 1 O -1 + + + + DiffMono + -0.984016 + + + + Formula + C 4 H 6 N 2 O 2 + + + + MassAvg + 114.10 + + + + MassMono + 114.042927 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00012 + MOD:00674 + MOD:00904 + PSI-MOD + + + MOD:01186 + acetylated L-threonine + + A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine. + + 18688235 + PubMed + + + PSI-MOD-slim + + AcThr + PSI-MOD-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + T + + + + Source + natural + + MOD:00394 + MOD:00917 + PSI-MOD + + + MOD:01187 + L-pyrrolysine residue + + A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification. + + 21860 + ChEBI + + + 11435424 + PubMed + + + 12029131 + PubMed + + + 12029132 + PubMed + + + 15314242 + PubMed + + + 16096277 + PubMed + + + AA0321 + RESID + + + 435 + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid + RESID-systematic + + + 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid + RESID-alternate + + + L-pyrrolysine + RESID-name + + + monomethylamine methyltransferase cofactor lysine adduct + RESID-alternate + + + N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine + RESID-alternate + + + N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine + RESID-alternate + + + N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine + RESID-alternate + + + NON_STD Pyrrolysine + UniProt-feature + + + Pyl + PSI-MOD-label + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 12 H 19 N 3 O 2 + + + + MassAvg + 237.30 + + + + MassMono + 237.147727 + + + + Origin + O + + + + Source + natural + + + + TermSpec + none + + MOD:00868 + PSI-MOD + + + MOD:01188 + N-ethyl iodoacetamide-d5 - site Y + + modification from UniMod Isotopic label - + + 11710128 + PubMed + + + 12766232 + PubMed + + + 3155470 + PubMed + + + 957432 + PubMed + + + 212#Y + UniMod + + + + N-ethyl iodoacetamide-d5 + UniMod-description + + + NEIAA:2H(5) + PSI-MS-label + + + + DiffAvg + 90.08 + + + + DiffFormula + C 4 (1)H 2 (2)H 5 N 1 O 1 + + + + DiffMono + 90.084148 + + + + Formula + C 13 (1)H 11 (2)H 5 N 2 O 3 + + + + MassAvg + 253.15 + + + + MassMono + 253.147476 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00562 + PSI-MOD + + + MOD:01189 + N-ethyl iodoacetamide-d5 - site C + + modification from UniMod Isotopic label - + + 12766232 + PubMed + + + 212#C + UniMod + + + + N-ethyl iodoacetamide-d5 + UniMod-description + + + NEIAA:2H(5) + PSI-MS-label + + + + DiffAvg + 90.08 + + + + DiffFormula + C 4 (1)H 2 (2)H 5 N 1 O 1 + + + + DiffMono + 90.084148 + + + + Formula + C 7 (1)H 7 (2)H 5 N 2 O 2 S 1 + + + + MassAvg + 193.09 + + + + MassMono + 193.093332 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00562 + PSI-MOD + + + MOD:01190 + dibromo + + Modification from UniMod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006. + + 534 + UniMod + + + + Dibromo + PSI-MS-label + + + Dibromo + UniMod-description + + + + DiffAvg + 157.79 + + + + DiffFormula + Br 2 H -2 + + + + DiffMono + 155.821024 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Y + + + + Source + none + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01191 + N-ethyl iodoacetamide-d0 - site C + + modification from UniMod Isotopic label - + + 12766232 + PubMed + + + 211#C + UniMod + + + + N-ethyl iodoacetamide-d0 + UniMod-description + + + NEIAA + PSI-MS-label + + + + DiffAvg + 85.11 + + + + DiffFormula + C 4 H 7 N 1 O 1 + + + + DiffMono + 85.052764 + + + + Formula + C 7 H 12 N 2 O 2 S 1 + + + + MassAvg + 188.25 + + + + MassMono + 188.061949 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00561 + PSI-MOD + + + MOD:01192 + N-ethyl iodoacetamide-d0 - site Y + + modification from UniMod Isotopic label - + + 11760118 + PubMed + + + 12766232 + PubMed + + + 211#Y + UniMod + + + + N-ethyl iodoacetamide-d0 + UniMod-description + + + NEIAA + PSI-MS-label + + + + DiffAvg + 85.11 + + + + DiffFormula + C 4 H 7 N 1 O 1 + + + + DiffMono + 85.052764 + + + + Formula + C 13 H 16 N 2 O 3 + + + + MassAvg + 248.28 + + + + MassMono + 248.116092 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00561 + PSI-MOD + + + MOD:01193 + phosphorylation to pyridyl thiol - site T + + modification from UniMod Chemical derivative - + + 1093385 + PubMed + + + 264#T + UniMod + + + + PET + PSI-MS-label + + + phosphorylation to pyridyl thiol + UniMod-description + + + + DiffAvg + 121.20 + + + + DiffFormula + C 7 H 7 N 1 O -1 S 1 + + + + DiffMono + 121.035006 + + + + Formula + C 11 H 14 N 2 O 1 S 1 + + + + MassAvg + 222.31 + + + + MassMono + 222.082684 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00586 + PSI-MOD + + + MOD:01194 + phosphorylation to pyridyl thiol - site S + + modification from UniMod Chemical derivative - + + 15279557 + PubMed + + + 264#S + UniMod + + + + PET + PSI-MS-label + + + phosphorylation to pyridyl thiol + UniMod-description + + + + DiffAvg + 121.20 + + + + DiffFormula + C 7 H 7 N 1 O -1 S 1 + + + + DiffMono + 121.035006 + + + + Formula + C 10 H 12 N 2 O 1 S 1 + + + + MassAvg + 208.28 + + + + MassMono + 208.067034 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00586 + PSI-MOD + + + MOD:01195 + benzoyl labeling reagent light form - site K + + modification from UniMod Isotopic label - + + 11813307 + PubMed + + + 12777388 + PubMed + + + 15456300 + PubMed + + + 136#K + UniMod + + + + Benzoyl + PSI-MS-label + + + labeling reagent light form (N-term & K) + UniMod-description + + + + DiffAvg + 104.11 + + + + DiffFormula + C 7 H 4 O 1 + + + + DiffMono + 104.026215 + + + + Formula + C 13 H 16 N 2 O 2 + + + + MassAvg + 232.28 + + + + MassMono + 232.121178 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00505 + PSI-MOD + + + MOD:01196 + 5-dimethylaminonaphthalene-1-sulfonyl - site K + + OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654. + + 139 + UniMod + + + + 5-dimethylaminonaphthalene-1-sulfonyl + UniMod-description + + + Dansyl + PSI-MS-label + + + + DiffAvg + 233.29 + + + + DiffFormula + C 12 H 11 N 1 O 2 S 1 + + + + DiffMono + 233.051050 + + + + Formula + C 18 H 23 N 3 O 3 S 1 + + + + MassAvg + 361.46 + + + + MassMono + 361.146013 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01197 + N-heptosyl-L-glutamine + + A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine. + + 490#Q + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + C 12 H 20 N 2 O 8 + + + + MassAvg + 320.30 + + + + MassMono + 320.121966 + + + + Origin + Q + + + + Source + artifact + + + + TermSpec + none + + MOD:00925 + PSI-MOD + + + MOD:01198 + O-heptosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine. + + 490#S + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + C 10 H 17 N 1 O 8 + + + + MassAvg + 279.25 + + + + MassMono + 279.095417 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00925 + PSI-MOD + + + MOD:01199 + N-heptosyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine. + + 490#R + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + C 13 H 24 N 4 O 7 + + + + MassAvg + 348.36 + + + + MassMono + 348.164499 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00925 + PSI-MOD + + + MOD:01200 + O-heptosyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine. + + 490#T + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + C 11 H 19 N 1 O 8 + + + + MassAvg + 293.27 + + + + MassMono + 293.111067 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00925 + PSI-MOD + + + MOD:01201 + N6-heptosyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine. + + 490#K + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + C 13 H 24 N 2 O 7 + + + + MassAvg + 320.34 + + + + MassMono + 320.158351 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00925 + PSI-MOD + + + MOD:01202 + N-heptosyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine. + + 490#N + UniMod + + + From UniMod with no citation [JSG]. + + Hep + PSI-MS-label + + + Heptose + UniMod-description + + + + DiffAvg + 192.17 + + + + DiffFormula + C 7 H 12 O 6 + + + + DiffMono + 192.063388 + + + + Formula + C 11 H 18 N 2 O 8 + + + + MassAvg + 306.27 + + + + MassMono + 306.106316 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:00925 + PSI-MOD + + + MOD:01203 + N6-(pyridylacetyl)lysine + + A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine. + + 9276974 + PubMed + + + 25#K + UniMod + + + Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. + + Pyridylacetyl + PSI-MS-label + + + pyridylacetyl + UniMod-description + + + + DiffAvg + 119.12 + + + + DiffFormula + C 7 H 5 N 1 O 1 + + + + DiffMono + 119.037114 + + + + Formula + C 13 H 17 N 3 O 2 + + + + MassAvg + 247.30 + + + + MassMono + 247.132077 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00418 + MOD:01875 + PSI-MOD + + + MOD:01204 + prompt loss of methanethiol from oxidixed methionine + + modification from UniMod Artifact - + + 9004526 + PubMed + + + 526 + UniMod + + + + Dethiomethyl + PSI-MS-label + + + Prompt loss of side chain from oxidised Met + UniMod-description + + + + DiffAvg + -48.10 + + + + DiffFormula + C -1 H -4 S -1 + + + + DiffMono + -48.003371 + + + + Formula + C 4 H 5 N 1 O 1 S 0 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00913 + PSI-MOD + + + MOD:01205 + Hex1HexNAc1NeuAc2 O-glycosylated serine + + A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. + + 7949339 + PubMed + + + 160#S + UniMod + + + + Hex(1)HexNAc(1)NeuAc(2) + PSI-MS-label + + + Hex1HexNAc1NeuAc2 + UniMod-description + + + + DiffAvg + 947.85 + + + + DiffFormula + C 36 H 57 N 3 O 26 + + + + DiffMono + 947.323029 + + + + Formula + C 39 H 62 N 4 O 28 + + + + MassAvg + 1034.93 + + + + MassMono + 1034.355057 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00528 + MOD:00916 + PSI-MOD + + + MOD:01206 + Hex1HexNAc1NeuAc2 O-glycosylated threonine + + A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. + + 160#T + UniMod + + + + Hex(1)HexNAc(1)NeuAc(2) + PSI-MS-label + + + Hex1HexNAc1NeuAc2 + UniMod-description + + + + DiffAvg + 947.85 + + + + DiffFormula + C 36 H 57 N 3 O 26 + + + + DiffMono + 947.323029 + + + + Formula + C 40 H 64 N 4 O 28 + + + + MassAvg + 1048.95 + + + + MassMono + 1048.370707 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00528 + MOD:00917 + PSI-MOD + + + MOD:01207 + Hex1HexNAc1NeuAc2 N4-glycosylated asparagine + + A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. + + 160#N + UniMod + + + + Hex(1)HexNAc(1)NeuAc(2) + PSI-MS-label + + + Hex1HexNAc1NeuAc2 + UniMod-description + + + + DiffAvg + 947.85 + + + + DiffFormula + C 36 H 57 N 3 O 26 + + + + DiffMono + 947.323029 + + + + Formula + C 40 H 63 N 5 O 28 + + + + MassAvg + 1061.95 + + + + MassMono + 1061.365956 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00528 + MOD:00903 + PSI-MOD + + + MOD:01208 + copper(1+) carboxylate C-terminal residue + + A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt. + + 531#C-term + UniMod + + + + Cation:Cu[I] + PSI-MS-label + + + cuprous salt + PSI-MOD-alternate + + + Replacement of proton by copper + UniMod-description + + + + DiffAvg + 62.54 + + + + DiffFormula + Cu 1 H -1 + + + + DiffMono + 61.921772 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + C-term + + MOD:00742 + PSI-MOD + + + MOD:01209 + copper(1+) L-aspartate + + A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt. + + 531#D + UniMod + + + + Cation:Cu[I] + PSI-MS-label + + + cuprous salt + PSI-MOD-alternate + + + Replacement of proton by copper + UniMod-description + + + + DiffAvg + 62.54 + + + + DiffFormula + Cu 1 H -1 + + + + DiffMono + 61.921772 + + + + Formula + C 4 Cu 1 H 4 N 1 O 3 + + + + MassAvg + 177.63 + + + + MassMono + 176.948715 + + + + Origin + D + + + + Source + none + + + + TermSpec + none + + MOD:00742 + MOD:00904 + PSI-MOD + + + MOD:01210 + copper(1+) L-glutamate + + A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt. + + 531#E + UniMod + + + + Cation:Cu[I] + PSI-MS-label + + + cuprous salt + PSI-MOD-alternate + + + Replacement of proton by copper + UniMod-description + + + + DiffAvg + 62.54 + + + + DiffFormula + Cu 1 H -1 + + + + DiffMono + 61.921772 + + + + Formula + C 5 Cu 1 H 6 N 1 O 3 + + + + MassAvg + 191.65 + + + + MassMono + 190.964366 + + + + Origin + E + + + + Source + none + + + + TermSpec + none + + MOD:00742 + MOD:00906 + PSI-MOD + + + MOD:01211 + N6-(morpholine-2-acetyl)-lysine + + A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine. + + 10446193 + PubMed + + + 29#K + UniMod + + + The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. + + N-Succinimidyl-2-morpholine acetate + UniMod-description + + + N-succinimidylmorpholine-2-acetate N6-derivatized lysine + PSI-MOD-alternate + + + SMA + PSI-MS-label + + + + DiffAvg + 127.14 + + + + DiffFormula + C 6 H 9 N 1 O 2 + + + + DiffMono + 127.063329 + + + + Formula + C 12 H 21 N 3 O 3 + + + + MassAvg + 255.32 + + + + MassMono + 255.158292 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01813 + MOD:01875 + PSI-MOD + + + MOD:01212 + iodoacetamide N6-derivatized lysine + + A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine. + + 11510821 + PubMed + + + 12422359 + PubMed + + + 12686488 + PubMed + + + 4#K + UniMod + + + PSI-MOD-slim + + Carbamidomethyl + PSI-MS-label + + + carbamidomethylk + OMSSA-label + + + Iodoacetamide derivative + UniMod-description + + + N6-(2-amino-2-oxoethyl)lysine + PSI-MOD-alternate + + + N6-(carbamoylmethyl)lysine + PSI-MOD-alternate + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + C 8 H 15 N 3 O 2 + + + + MassAvg + 185.23 + + + + MassMono + 185.116427 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00912 + PSI-MOD + + + MOD:01213 + iodoacetamide derivatized histidine + + A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine. + + 11510821 + PubMed + + + 12422359 + PubMed + + + 15627961 + PubMed + + + 2026710 + PubMed + + + 4#H + UniMod + + + PSI-MOD-slim + + Carbamidomethyl + PSI-MS-label + + + carbamidometylh + OMSSA-label + + + Iodoacetamide derivative + UniMod-description + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + C 8 H 10 N 4 O 2 + + + + MassAvg + 194.19 + + + + MassMono + 194.080376 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00909 + PSI-MOD + + + MOD:01214 + iodoacetamide - site C + + modification from UniMod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. + + 10504701 + PubMed + + + 11510821 + PubMed + + + 12422359 + PubMed + + + 4#C + UniMod + + + + Carbamidomethyl + PSI-MS-label + + + Iodoacetamide derivative + UniMod-description + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01215 + iodoacetamide derivatized aspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate. + + 11510821 + PubMed + + + 12422359 + PubMed + + + 16526082 + PubMed + + + 4#D + UniMod + + + PSI-MOD-slim + + Carbamidomethyl + PSI-MS-label + + + carbamidomethyld + OMSSA-label + + + Iodoacetamide derivative + UniMod-description + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + C 6 H 8 N 2 O 4 + + + + MassAvg + 172.14 + + + + MassMono + 172.048407 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00904 + PSI-MOD + + + MOD:01216 + iodoacetamide derivatized glutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate. + + 11510821 + PubMed + + + 12422359 + PubMed + + + 4#E + UniMod + + + PSI-MOD-slim + + Carbamidomethyl + PSI-MS-label + + + carbamidomethyle + OMSSA-label + + + Iodoacetamide derivative + UniMod-description + + + + DiffAvg + 57.05 + + + + DiffFormula + C 2 H 3 N 1 O 1 + + + + DiffMono + 57.021464 + + + + Formula + C 7 H 10 N 2 O 4 + + + + MassAvg + 186.17 + + + + MassMono + 186.064057 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00906 + PSI-MOD + + + MOD:01217 + Sulfanilic Acid (SA), light C12 - site D + + modification from UniMod Isotopic label - + + 12872131 + PubMed + + + 285#D + UniMod + + + + Light Sulfanilic Acid (SA) C12 + UniMod-description + + + SulfanilicAcid + PSI-MS-label + + + + DiffAvg + 155.00 + + + + DiffFormula + (12)C 6 H 5 N 1 O 2 S 1 + + + + DiffMono + 155.004099 + + + + Formula + (12)C 10 H 10 N 2 O 5 S 1 + + + + MassAvg + 270.03 + + + + MassMono + 270.031042 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00605 + PSI-MOD + + + MOD:01218 + Sulfanilic Acid (SA), light C12 - site E + + modification from UniMod Isotopic label - + + 15283597 + PubMed + + + 285#E + UniMod + + + + Light Sulfanilic Acid (SA) C12 + UniMod-description + + + SulfanilicAcid + PSI-MS-label + + + + DiffAvg + 155.00 + + + + DiffFormula + (12)C 6 H 5 N 1 O 2 S 1 + + + + DiffMono + 155.004099 + + + + Formula + (12)C 11 H 12 N 2 O 5 S 1 + + + + MassAvg + 284.05 + + + + MassMono + 284.046692 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00605 + PSI-MOD + + + MOD:01219 + Sulfanilic Acid (SA), heavy C13 - site D + + modification from UniMod Chemical derivative - + + 9254591 + PubMed + + + 9750125 + PubMed + + + 286#D + UniMod + + + + Heavy Sulfanilic Acid (SA) C13 + UniMod-description + + + SulfanilicAcid:13C(6) + PSI-MS-label + + + + DiffAvg + 161.02 + + + + DiffFormula + (13)C 6 H 5 N 1 O 2 S 1 + + + + DiffMono + 161.024228 + + + + Formula + (12)C 4 (13)C 6 H 10 N 2 O 5 S 1 + + + + MassAvg + 276.05 + + + + MassMono + 276.051171 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00606 + PSI-MOD + + + MOD:01220 + Sulfanilic Acid (SA), heavy C13 - site E + + modification from UniMod Chemical derivative - + + 15121203 + PubMed + + + 9254591 + PubMed + + + 286#E + UniMod + + + + Heavy Sulfanilic Acid (SA) C13 + UniMod-description + + + SulfanilicAcid:13C(6) + PSI-MS-label + + + + DiffAvg + 161.02 + + + + DiffFormula + (13)C 6 H 5 N 1 O 2 S 1 + + + + DiffMono + 161.024228 + + + + Formula + (12)C 5 (13)C 6 H 12 N 2 O 5 S 1 + + + + MassAvg + 290.07 + + + + MassMono + 290.066822 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00606 + PSI-MOD + + + MOD:01221 + O-formyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine. + + 11861642 + PubMed + + + 15799070 + PubMed + + + 122#T + UniMod + + + From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). + + Formyl + PSI-MS-label + + + Formylation + UniMod-description + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01483 + PSI-MOD + + + MOD:01222 + O-formyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-formyl-L-serine. + + 15627961 + PubMed + + + 15799070 + PubMed + + + 122#S + UniMod + + + From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). + + Formyl + PSI-MS-label + + + Formylation + UniMod-description + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01483 + PSI-MOD + + + MOD:01223 + thioacylation of primary amines - site N-term + + modification from UniMod Other - + + 11710128 + PubMed + + + 3155470 + PubMed + + + 957432 + PubMed + + + 126#N-term + UniMod + + + This UniMod entry is misdescribed as "thioacylation" [JSG]. + + 3,3-Dithio-bis-(sulfosuccinimidyl)propionate + UniMod-alternate + + + ntermpeptioacetyl + OMSSA-label + + + Thioacyl + PSI-MS-label + + + thioacylation of primary amines (N-term and Lys) + UniMod-description + + + + DiffAvg + 88.12 + + + + DiffFormula + C 3 H 4 O 1 S 1 + + + + DiffMono + 87.998286 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00497 + PSI-MOD + + + MOD:01224 + thioacylation of primary amines - site K + + modification from UniMod Other - + + 11710128 + PubMed + + + 3155470 + PubMed + + + 957432 + PubMed + + + 126#K + UniMod + + + This UniMod entry is misdescribed as "thioacylation" [JSG]. + + 3,3-Dithio-bis-(sulfosuccinimidyl)propionate + UniMod-alternate + + + thioacetylk + OMSSA-label + + + Thioacyl + PSI-MS-label + + + thioacylation of primary amines (N-term and Lys) + UniMod-description + + + + DiffAvg + 88.12 + + + + DiffFormula + C 3 H 4 O 1 S 1 + + + + DiffMono + 87.998286 + + + + Formula + C 9 H 16 N 2 O 2 S 1 + + + + MassAvg + 216.30 + + + + MassMono + 216.093249 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00497 + PSI-MOD + + + MOD:01225 + monofluorinated L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine. + + 8069568 + PubMed + + + 127#Y + UniMod + + + From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. + + Fluoro + PSI-MS-label + + + fluorophenylalanine replacement of phenylalanine + UniMod-description + + + phef + OMSSA-label + + + + DiffAvg + 17.99 + + + + DiffFormula + F 1 H -1 + + + + DiffMono + 17.990578 + + + + Formula + C 9 F 1 H 8 N 1 O 2 + + + + MassAvg + 181.17 + + + + MassMono + 181.053907 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00498 + MOD:00985 + PSI-MOD + + + MOD:01226 + monofluorinated L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan. + + 8069568 + PubMed + + + 127#W + UniMod + + + From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. + + Fluoro + PSI-MS-label + + + fluorophenylalanine replacement of phenylalanine + UniMod-description + + + + DiffAvg + 17.99 + + + + DiffFormula + F 1 H -1 + + + + DiffMono + 17.990578 + + + + Formula + C 11 F 1 H 9 N 2 O 1 + + + + MassAvg + 204.20 + + + + MassMono + 204.069891 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00498 + MOD:01068 + PSI-MOD + + + MOD:01227 + monofluorinated L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine. + + 181 + DeltaMass + + + 8069568 + PubMed + + + 127#F + UniMod + + + From UniMod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG]. + + Fluoro + PSI-MS-label + + + fluorophenylalanine replacement of phenylalanine + UniMod-description + + + phef + OMSSA-label + + + + DiffAvg + 17.99 + + + + DiffFormula + C 0 F 1 H -1 N 0 O 0 + + + + DiffMono + 17.990578 + + + + Formula + C 9 F 1 H 8 N 1 O 1 + + + + MassAvg + 165.17 + + + + MassMono + 165.058992 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00498 + MOD:01066 + PSI-MOD + + + MOD:01228 + monoiodinated tyrosine + + A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom. + + 0 + DeltaMass + + + 1326520 + PubMed + + + 15627961 + PubMed + + + 2026710 + PubMed + + + 129#Y + UniMod + + + From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG]. + PSI-MOD-slim + + I1Tyr + PSI-MOD-label + + + Iodination + UniMod-description + + + iodinationy + OMSSA-label + + + Iodo + PSI-MS-label + + + + DiffAvg + 125.90 + + + + DiffFormula + H -1 I 1 + + + + DiffMono + 125.896648 + + + + Formula + C 9 H 8 I 1 N 1 O 2 + + + + MassAvg + 289.07 + + + + MassMono + 288.959976 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00500 + MOD:00998 + PSI-MOD + + + MOD:01229 + L-iodohistidine + + A protein modification that effectively converts an L-histidine residue to an L-iodohistidine. + + 15627961 + PubMed + + + 2026710 + PubMed + + + 129#H + UniMod + + + + I1His + PSI-MOD-label + + + Iodination + UniMod-description + + + Iodo + PSI-MS-label + + + + DiffAvg + 125.90 + + + + DiffFormula + C 0 H -1 I 1 N 0 O 0 + + + + DiffMono + 125.896648 + + + + Formula + C 6 H 6 I 1 N 3 O 1 + + + + MassAvg + 263.04 + + + + MassMono + 262.955560 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00500 + MOD:01049 + PSI-MOD + + + MOD:01230 + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form - site K + + modification from UniMod Isotopic label - + + 15602776 + PubMed + + + 365#K + UniMod + + + + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form + UniMod-description + + + ICPL + PSI-MS-label + + + + DiffAvg + 105.02 + + + + DiffFormula + (12)C 6 H 3 N 1 O 1 + + + + DiffMono + 105.021464 + + + + Formula + (12)C 12 H 15 N 3 O 2 + + + + MassAvg + 233.12 + + + + MassMono + 233.116427 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00790 + PSI-MOD + + + MOD:01231 + 3x(13)C labeled N6-propanoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 12442261 + PubMed + + + 59#K + UniMod + + + PSI-MOD-slim + + Propionate labeling reagent heavy form (+3amu), N-term & K + UniMod-description + + + Propionyl:13C(3) + PSI-MS-label + + + + DiffAvg + 59.04 + + + + DiffFormula + (13)C 3 H 4 O 1 + + + + DiffMono + 59.036279 + + + + Formula + (12)C 6 (13)C 3 H 16 N 2 O 2 + + + + MassAvg + 187.13 + + + + MassMono + 187.131242 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01398 + PSI-MOD + + + MOD:01232 + 3x(12)C labeled N6-propanoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 58#K + UniMod + + + PSI-MOD-slim + + Propionate labeling reagent light form (N-term & K) + UniMod-description + + + Propionyl + PSI-MS-label + + + + DiffAvg + 56.03 + + + + DiffFormula + (12)C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + (12)C 9 H 16 N 2 O 2 + + + + MassAvg + 184.12 + + + + MassMono + 184.121178 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01398 + PSI-MOD + + + MOD:01233 + 3x(2)H labeled N6-acetyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 56#K + UniMod + + + PSI-MOD-slim + + Acetate labeling reagent (N-term & K) (heavy form, +3amu) + UniMod-description + + + Acetyl:2H(3) + PSI-MS-label + + + + DiffAvg + 45.03 + + + + DiffFormula + C 2 (1)H -1 (2)H 3 O 1 + + + + DiffMono + 45.029395 + + + + Formula + C 8 (1)H 11 (2)H 3 N 2 O 2 + + + + MassAvg + 173.12 + + + + MassMono + 173.124358 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00064 + MOD:00449 + PSI-MOD + + + MOD:01234 + (18)O monosubstituted L-serine + + modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate + + 11467524 + PubMed + + + 258#S + UniMod + + + PSI-MOD-slim + + Label:18O(1) + PSI-MS-label + + + O18 Labeling + UniMod-description + + + + DiffAvg + 2.00 + + + + DiffFormula + (16)O -1 (18)O 1 + + + + DiffMono + 2.004246 + + + + Formula + C 3 H 5 N 1 (16)O 1 (18)O 1 + + + + MassAvg + 89.04 + + + + MassMono + 89.036275 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00581 + MOD:00916 + PSI-MOD + + + MOD:01235 + (18)O monosubstituted L-threonine + + modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate + + 11467524 + PubMed + + + 15549660 + PubMed + + + 258#T + UniMod + + + PSI-MOD-slim + + Label:18O(1) + PSI-MS-label + + + O18 Labeling + UniMod-description + + + + DiffAvg + 2.00 + + + + DiffFormula + (16)O -1 (18)O 1 + + + + DiffMono + 2.004246 + + + + Formula + C 4 H 7 N 1 (16)O 1 (18)O 1 + + + + MassAvg + 103.05 + + + + MassMono + 103.051925 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00581 + MOD:00917 + PSI-MOD + + + MOD:01236 + (18)O monosubstituted L-tyrosine + + modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate + + 11467524 + PubMed + + + 15549660 + PubMed + + + 258#Y + UniMod + + + PSI-MOD-slim + + Label:18O(1) + PSI-MS-label + + + O18 Labeling + UniMod-description + + + + DiffAvg + 2.00 + + + + DiffFormula + (16)O -1 (18)O 1 + + + + DiffMono + 2.004246 + + + + Formula + C 9 H 9 N 1 (16)O 1 (18)O 1 + + + + MassAvg + 165.07 + + + + MassMono + 165.067575 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00581 + MOD:00919 + PSI-MOD + + + MOD:01237 + cysteine 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal. + + 11327326 + PubMed + + + 15133838 + PubMed + + + 9629898 + PubMed + + + 53#C + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + 4-hydroxynonenal (HNE) + UniMod-description + + + HNE + PSI-MS-label + + + + DiffAvg + 156.22 + + + + DiffFormula + C 9 H 16 O 2 + + + + DiffMono + 156.115030 + + + + Formula + C 12 H 21 N 1 O 3 S 1 + + + + MassAvg + 259.36 + + + + MassMono + 259.124215 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00446 + PSI-MOD + + + MOD:01238 + lysine 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal. + + 11327326 + PubMed + + + 15133838 + PubMed + + + 9629898 + PubMed + + + 53#K + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + 4-hydroxynonenal (HNE) + UniMod-description + + + HNE + PSI-MS-label + + + + DiffAvg + 156.22 + + + + DiffFormula + C 9 H 16 O 2 + + + + DiffMono + 156.115030 + + + + Formula + C 15 H 28 N 2 O 3 + + + + MassAvg + 284.40 + + + + MassMono + 284.209993 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00446 + PSI-MOD + + + MOD:01239 + histidine 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal. + + 10717661 + PubMed + + + 11327326 + PubMed + + + 15133838 + PubMed + + + 53#H + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + 4-hydroxynonenal (HNE) + UniMod-description + + + HNE + PSI-MS-label + + + + DiffAvg + 156.22 + + + + DiffFormula + C 9 H 16 O 2 + + + + DiffMono + 156.115030 + + + + Formula + C 15 H 23 N 3 O 3 + + + + MassAvg + 293.37 + + + + MassMono + 293.173942 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00446 + PSI-MOD + + + MOD:01240 + ubiquitination signature tetrapeptidyl lysine + + A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin. + + 10504701 + PubMed + + + 535 + UniMod + + + + LeuArgGlyGly + PSI-MS-label + + + Ubiquitination + UniMod-description + + + + DiffAvg + 383.45 + + + + DiffFormula + C 16 H 29 N 7 O 4 + + + + DiffMono + 383.228102 + + + + Formula + C 22 H 41 N 9 O 5 + + + + MassAvg + 511.63 + + + + MassMono + 511.323065 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00908 + MOD:01875 + + derives_from + MOD:011480 + + PSI-MOD + + + MOD:01241 + 3x(2)H labeled L-aspartic acid 4-methyl ester + + A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester. + + 12185208 + PubMed + + + 298#D + UniMod + + + + deuterated methyl ester + UniMod-description + + + Methyl:2H(3) + PSI-MS-label + + + trideuteromethyld + OMSSA-label + + + + DiffAvg + 17.03 + + + + DiffFormula + C 1 (1)H -1 (2)H 3 + + + + DiffMono + 17.034480 + + + + Formula + C 5 (1)H 4 (2)H 3 N 1 O 3 + + + + MassAvg + 132.06 + + + + MassMono + 132.061423 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00617 + MOD:00904 + + derives_from + MOD:011810 + + PSI-MOD + + + MOD:01242 + 3x(2)H labeled L-glutamic acid 5-methyl ester + + A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester. + + 1326520 + PubMed + + + 298#E + UniMod + + + + deuterated methyl ester + UniMod-description + + + Methyl:2H(3) + PSI-MS-label + + + trideuteromethyle + OMSSA-label + + + + DiffAvg + 17.03 + + + + DiffFormula + C 1 (1)H -1 (2)H 3 + + + + DiffMono + 17.034480 + + + + Formula + C 6 (1)H 6 (2)H 3 N 1 O 3 + + + + MassAvg + 146.08 + + + + MassMono + 146.077073 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00617 + MOD:00906 + + derives_from + MOD:000810 + + PSI-MOD + + + MOD:01243 + potassium carboxylate C-terminal residue + + A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt. + + 530#C-term + UniMod + + + + Cation:K + PSI-MS-label + + + Replacement of proton by potassium + UniMod-description + + + + DiffAvg + 38.09 + + + + DiffFormula + H -1 K 1 + + + + DiffMono + 37.955882 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + C-term + + MOD:01072 + PSI-MOD + + + MOD:01244 + potassium L-glutamate + + A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt. + + 530#E + UniMod + + + + Cation:K + PSI-MS-label + + + Replacement of proton by potassium + UniMod-description + + + + DiffAvg + 38.09 + + + + DiffFormula + H -1 K 1 + + + + DiffMono + 37.955882 + + + + Formula + C 5 H 6 K 1 N 1 O 3 + + + + MassAvg + 167.21 + + + + MassMono + 166.998475 + + + + Origin + E + + + + Source + none + + + + TermSpec + none + + MOD:00906 + MOD:01072 + PSI-MOD + + + MOD:01245 + potassium L-aspartate + + A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt. + + 530#D + UniMod + + + + Cation:K + PSI-MS-label + + + Replacement of proton by potassium + UniMod-description + + + + DiffAvg + 38.09 + + + + DiffFormula + H -1 K 1 + + + + DiffMono + 37.955882 + + + + Formula + C 4 H 4 K 1 N 1 O 3 + + + + MassAvg + 153.18 + + + + MassMono + 152.982825 + + + + Origin + D + + + + Source + none + + + + TermSpec + none + + MOD:00904 + MOD:01072 + PSI-MOD + + + MOD:01246 + fucosylated -site S + + OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812. + + 11344537 + PubMed + + + 15189151 + PubMed + + + 3311742 + PubMed + + + 3578767 + PubMed + + + 295#S + UniMod + + + + dHex + PSI-MS-label + + + Fucose + UniMod-description + + + + DiffAvg + 147.15 + + + + DiffFormula + C 6 H 11 O 4 + + + + DiffMono + 147.065734 + + + + Formula + C 9 H 16 N 1 O 6 + + + + MassAvg + 234.23 + + + + MassMono + 234.097762 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01247 + fucosylated -site T + + OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813. + + 11344537 + PubMed + + + 11857757 + PubMed + + + 15189151 + PubMed + + + 295#T + UniMod + + + + dHex + PSI-MS-label + + + Fucose + UniMod-description + + + + DiffAvg + 147.15 + + + + DiffFormula + C 6 H 11 O 4 + + + + DiffMono + 147.065734 + + + + Formula + C 10 H 18 N 1 O 6 + + + + MassAvg + 248.26 + + + + MassMono + 248.113412 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01248 + iodouridine monophosphate derivatized tyrosine + + A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tyrosine residue to form an ether linkage. + + 11112526 + PubMed + + + 11567090 + PubMed + + + 6540775 + PubMed + + + 292#Y + UniMod + + + This has an ether linkage and not a phosphodiester linkage with UMP. + + Cross-link of (Iodo)-uracil MP with W,F,Y + UniMod-description + + + IodoU-AMP + PSI-MS-label + + + + DiffAvg + 322.17 + + + + DiffFormula + C 9 H 11 N 2 O 9 P 1 + + + + DiffMono + 322.020217 + + + + Formula + C 18 H 20 N 3 O 11 P 1 + + + + MassAvg + 485.34 + + + + MassMono + 485.083545 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00611 + MOD:00919 + PSI-MOD + + + MOD:01249 + iodouridine monophosphate derivatized tryptophan + + A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tryptophan residue. + + 11112526 + PubMed + + + 11567090 + PubMed + + + 6540775 + PubMed + + + 292#W + UniMod + + + This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP. + + Cross-link of (Iodo)-uracil MP with W,F,Y + UniMod-description + + + IodoU-AMP + PSI-MS-label + + + + DiffAvg + 322.17 + + + + DiffFormula + C 9 H 11 N 2 O 9 P 1 + + + + DiffMono + 322.020217 + + + + Formula + C 20 H 21 N 4 O 10 P 1 + + + + MassAvg + 508.38 + + + + MassMono + 508.099530 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00611 + MOD:00918 + PSI-MOD + + + MOD:01250 + iodouridine monophosphate derivatized phenylalanine + + A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-phenylalanine residue. + + 11112526 + PubMed + + + 11567090 + PubMed + + + 6540775 + PubMed + + + 292#F + UniMod + + + This has a carbon-carbon linkage and not a phosphodiester linkage with UMP. + + Cross-link of (Iodo)-uracil MP with W,F,Y + UniMod-description + + + IodoU-AMP + PSI-MS-label + + + + DiffAvg + 322.17 + + + + DiffFormula + C 9 H 11 N 2 O 9 P 1 + + + + DiffMono + 322.020217 + + + + Formula + C 18 H 20 N 3 O 10 P 1 + + + + MassAvg + 469.34 + + + + MassMono + 469.088630 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00611 + MOD:00914 + PSI-MOD + + + MOD:01251 + N6-[3-(carboxamidomethylthio)propanoyl]lysine + + A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine. + + 15121203 + PubMed + + + 293#K + UniMod + + + + 3-(carbamidomethylthio)propanoyl + UniMod-description + + + CAMthiopropanoyl + PSI-MS-label + + + + DiffAvg + 145.18 + + + + DiffFormula + C 5 H 7 N 1 O 2 S 1 + + + + DiffMono + 145.019749 + + + + Formula + C 11 H 19 N 3 O 3 S 1 + + + + MassAvg + 273.35 + + + + MassMono + 273.114712 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00612 + MOD:01875 + PSI-MOD + + + MOD:01252 + 5-hydro-5-methylimidazol-4-one, methylglyoxal arginine adduct (+54 amu) + + OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933. + + 9448752 + PubMed + + + 319#R + UniMod + + + + Delta:H(2)C(3)O(1) + PSI-MS-label + + + MDA adduct +54 + UniMod-description + + + + DiffAvg + 54.05 + + + + DiffFormula + C 3 H 2 O 1 + + + + DiffMono + 54.010565 + + + + Formula + C 9 H 14 N 4 O 2 + + + + MassAvg + 210.24 + + + + MassMono + 210.111676 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01253 + malondialdehyde lysine adduct (+54 amu) + + modification from UniMod Chemical derivative - Malondialdehyde (MDA) adduct + + 319#K + UniMod + + + + Delta:H(2)C(3)O(1) + PSI-MS-label + + + MDA adduct +54 + UniMod-description + + + + DiffAvg + 54.05 + + + + DiffFormula + C 3 H 2 O 1 + + + + DiffMono + 54.010565 + + + + Formula + C 9 H 14 N 2 O 2 + + + + MassAvg + 182.22 + + + + MassMono + 182.105528 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00630 + MOD:00912 + PSI-MOD + + + MOD:01254 + 4x(2)H labeled dimethylated L-lysine + + A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine. + + 14670044 + PubMed + + + 199#K + UniMod + + + PSI-MOD-slim + + DiMethyl-CHD2 + UniMod-description + + + Dimethyl:2H(4) + PSI-MS-label + + + mod189 + OMSSA-label + + + + DiffAvg + 32.06 + + + + DiffFormula + C 2 (2)H 4 + + + + DiffMono + 32.056407 + + + + Formula + C 8 H 12 (2)H 4 N 2 O 1 + + + + MassAvg + 160.15 + + + + MassMono + 160.151370 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00552 + MOD:00912 + + derives_from + MOD:000840 + + PSI-MOD + + + MOD:01255 + S-(2-sulfanylethyl)cysteine (Ser) + + A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine. + + 11507762 + PubMed + + + 200#S + UniMod + + + + EDT + UniMod-description + + + Ethanedithiol + PSI-MS-label + + + S-(2-mercaptoethyl)cysteine + PSI-MOD-alternate + + + + DiffAvg + 76.18 + + + + DiffFormula + C 2 H 4 O -1 S 2 + + + + DiffMono + 75.980528 + + + + Formula + C 5 H 9 N 1 O 1 S 2 + + + + MassAvg + 163.25 + + + + MassMono + 163.012556 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00553 + MOD:00916 + PSI-MOD + + + MOD:01256 + 3-methyl-S-(2-sulfanylethyl)cysteine (Thr) + + A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine. + + 11507762 + PubMed + + + 200#T + UniMod + + + + beta-methyl-S-(2-mercaptoethyl)cysteine + PSI-MOD-alternate + + + EDT + UniMod-description + + + Ethanedithiol + PSI-MS-label + + + + DiffAvg + 76.18 + + + + DiffFormula + C 2 H 4 O -1 S 2 + + + + DiffMono + 75.980528 + + + + Formula + C 6 H 11 N 1 O 1 S 2 + + + + MassAvg + 177.28 + + + + MassMono + 177.028206 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00553 + MOD:00917 + PSI-MOD + + + MOD:01257 + 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate - site K + + modification from UniMod Chemical derivative - + + 12716131 + PubMed + + + 14997490 + PubMed + + + 194#K + UniMod + + + + 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate + UniMod-description + + + AccQTag + PSI-MS-label + + + + DiffAvg + 170.17 + + + + DiffFormula + C 10 H 6 N 2 O 1 + + + + DiffMono + 170.048013 + + + + Formula + C 16 H 18 N 4 O 2 + + + + MassAvg + 298.35 + + + + MassMono + 298.142976 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00547 + PSI-MOD + + + MOD:01258 + N-methylmaleimide - site C + + modification from UniMod Chemical derivative - + + 9448752 + PubMed + + + 314#C + UniMod + + + + Nmethylmaleimide + PSI-MS-label + + + Nmethylmaleimide + UniMod-description + + + + DiffAvg + 111.10 + + + + DiffFormula + C 5 H 5 N 1 O 2 + + + + DiffMono + 111.032028 + + + + Formula + C 8 H 10 N 2 O 3 S 1 + + + + MassAvg + 214.24 + + + + MassMono + 214.041213 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00625 + MOD:00905 + PSI-MOD + + + MOD:01259 + N-methylmaleimide - site K + + modification from UniMod Chemical derivative - + + 9448752 + PubMed + + + 314#K + UniMod + + + + Nmethylmaleimide + PSI-MS-label + + + Nmethylmaleimide + UniMod-description + + + + DiffAvg + 111.10 + + + + DiffFormula + C 5 H 5 N 1 O 2 + + + + DiffMono + 111.032028 + + + + Formula + C 11 H 17 N 3 O 3 + + + + MassAvg + 239.27 + + + + MassMono + 239.126991 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00625 + MOD:00912 + PSI-MOD + + + MOD:01260 + nucleophilic addtion to cytopiloyne - site Y + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 270#Y + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + C 28 H 31 N 1 O 9 + + + + MassAvg + 525.55 + + + + MassMono + 525.199882 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00590 + MOD:00919 + PSI-MOD + + + MOD:01261 + nucleophilic addtion to cytopiloyne - site S + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 270#C + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + C 22 H 27 N 1 O 9 + + + + MassAvg + 449.46 + + + + MassMono + 449.168581 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00590 + MOD:00916 + PSI-MOD + + + MOD:01262 + nucleophilic addtion to cytopiloyne - site R + + modification from UniMod Chemical derivative - + + 12590383 + PubMed + + + 15549660 + PubMed + + + 270#R + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + C 25 H 34 N 4 O 8 + + + + MassAvg + 518.57 + + + + MassMono + 518.237664 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00590 + MOD:00902 + PSI-MOD + + + MOD:01263 + nucleophilic addtion to cytopiloyne - site K + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 270#K + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + C 25 H 34 N 2 O 8 + + + + MassAvg + 490.55 + + + + MassMono + 490.231516 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00590 + MOD:00912 + PSI-MOD + + + MOD:01264 + nucleophilic addtion to cytopiloyne - site C + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 270#C + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + C 22 H 27 N 1 O 8 S 1 + + + + MassAvg + 465.52 + + + + MassMono + 465.145738 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00590 + MOD:00905 + PSI-MOD + + + MOD:01265 + nucleophilic addtion to cytopiloyne - site P + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 270#P + UniMod + + + + Cytopiloyne + PSI-MS-label + + + nucleophilic addtion to cytopiloyne + UniMod-description + + + + DiffAvg + 362.38 + + + + DiffFormula + C 19 H 22 O 7 + + + + DiffMono + 362.136553 + + + + Formula + C 24 H 29 N 1 O 8 + + + + MassAvg + 459.50 + + + + MassMono + 459.189317 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00590 + MOD:00915 + PSI-MOD + + + MOD:01266 + nucleophilic addition to cytopiloyne+H2O - site C + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 271#C + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + C 22 H 29 N 1 O 9 S 1 + + + + MassAvg + 483.53 + + + + MassMono + 483.156303 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00591 + MOD:00905 + PSI-MOD + + + MOD:01267 + nucleophilic addition to cytopiloyne+H2O - site K + + modification from UniMod Chemical derivative - + + 11746907 + PubMed + + + 15549660 + PubMed + + + 271#K + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + C 25 H 36 N 2 O 9 + + + + MassAvg + 508.57 + + + + MassMono + 508.242081 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00591 + MOD:00912 + PSI-MOD + + + MOD:01268 + nucleophilic addition to cytopiloyne+H2O - site T + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 271#T + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + C 23 H 31 N 1 O 10 + + + + MassAvg + 481.50 + + + + MassMono + 481.194796 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00591 + MOD:00917 + PSI-MOD + + + MOD:01269 + nucleophilic addition to cytopiloyne+H2O - site R + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 271#R + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + C 25 H 36 N 4 O 9 + + + + MassAvg + 536.58 + + + + MassMono + 536.248229 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00591 + MOD:00902 + PSI-MOD + + + MOD:01270 + nucleophilic addition to cytopiloyne+H2O - site S + + modification from UniMod Chemical derivative - + + 14670044 + PubMed + + + 15549660 + PubMed + + + 271#S + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + C 22 H 29 N 1 O 10 + + + + MassAvg + 467.47 + + + + MassMono + 467.179146 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00591 + MOD:00916 + PSI-MOD + + + MOD:01271 + nucleophilic addition to cytopiloyne+H2O - site Y + + modification from UniMod Chemical derivative - + + 15549660 + PubMed + + + 271#Y + UniMod + + + + Cytopiloyne+water + PSI-MS-label + + + nucleophilic addition to cytopiloyne+H2O + UniMod-description + + + + DiffAvg + 380.39 + + + + DiffFormula + C 19 H 24 O 8 + + + + DiffMono + 380.147118 + + + + Formula + C 28 H 33 N 1 O 10 + + + + MassAvg + 543.57 + + + + MassMono + 543.210446 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00591 + MOD:00919 + PSI-MOD + + + MOD:01272 + iminobiotinylation - site K + + modification from UniMod Chemical derivative - + + 9750125 + PubMed + + + 89#K + UniMod + + + + Iminobiotin + PSI-MS-label + + + Iminobiotinylation + UniMod-description + + + + DiffAvg + 225.31 + + + + DiffFormula + C 10 H 15 N 3 O 1 S 1 + + + + DiffMono + 225.093583 + + + + Formula + C 16 H 27 N 5 O 2 S 1 + + + + MassAvg + 353.49 + + + + MassMono + 353.188546 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00467 + MOD:01875 + PSI-MOD + + + MOD:01273 + O-[4-(2-aminoethyl)benzenesulfonyl] serine + + A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue. + + 15283597 + PubMed + + + 8597590 + PubMed + + + 276#S + UniMod + + + + AEBS + PSI-MS-label + + + Aminoethylbenzenesulfonylation + UniMod-description + + + + DiffAvg + 183.23 + + + + DiffFormula + C 8 H 9 N 1 O 2 S 1 + + + + DiffMono + 183.035400 + + + + Formula + C 11 H 14 N 2 O 4 S 1 + + + + MassAvg + 270.30 + + + + MassMono + 270.067428 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00596 + MOD:00916 + PSI-MOD + + + MOD:01274 + N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine + + A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue. + + 8597590 + PubMed + + + 276#H + UniMod + + + + AEBS + PSI-MS-label + + + Aminoethylbenzenesulfonylation + UniMod-description + + + + DiffAvg + 183.23 + + + + DiffFormula + C 8 H 9 N 1 O 2 S 1 + + + + DiffMono + 183.035400 + + + + Formula + C 14 H 16 N 4 O 3 S 1 + + + + MassAvg + 320.37 + + + + MassMono + 320.094311 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00596 + MOD:00909 + PSI-MOD + + + MOD:01275 + N6-[4-(2-aminoethyl)benzenesulfonyl]lysine + + A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue. + + 8597590 + PubMed + + + 276#K + UniMod + + + + AEBS + PSI-MS-label + + + Aminoethylbenzenesulfonylation + UniMod-description + + + + DiffAvg + 183.23 + + + + DiffFormula + C 8 H 9 N 1 O 2 S 1 + + + + DiffMono + 183.035400 + + + + Formula + C 14 H 21 N 3 O 3 S 1 + + + + MassAvg + 311.40 + + + + MassMono + 311.130363 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00596 + MOD:00912 + PSI-MOD + + + MOD:01276 + O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine + + A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue. + + 10906242 + PubMed + + + 8597590 + PubMed + + + 276#Y + UniMod + + + + AEBS + PSI-MS-label + + + Aminoethylbenzenesulfonylation + UniMod-description + + + + DiffAvg + 183.23 + + + + DiffFormula + C 8 H 9 N 1 O 2 S 1 + + + + DiffMono + 183.035400 + + + + Formula + C 17 H 18 N 2 O 4 S 1 + + + + MassAvg + 346.40 + + + + MassMono + 346.098728 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00596 + MOD:00919 + PSI-MOD + + + MOD:01277 + crotonaldehyde - site C + + modification from UniMod Other - + + 11283024 + PubMed + + + 253#C + UniMod + + + + Crotonaldehyde + PSI-MS-label + + + Crotonaldehyde + UniMod-description + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 O 1 + + + + DiffMono + 70.041865 + + + + Formula + C 7 H 11 N 1 O 2 S 1 + + + + MassAvg + 173.23 + + + + MassMono + 173.051050 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00576 + MOD:00905 + PSI-MOD + + + MOD:01278 + crotonaldehyde - site K + + modification from UniMod Other - + + 11283024 + PubMed + + + 253#K + UniMod + + + + Crotonaldehyde + PSI-MS-label + + + Crotonaldehyde + UniMod-description + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 O 1 + + + + DiffMono + 70.041865 + + + + Formula + C 10 H 18 N 2 O 2 + + + + MassAvg + 198.27 + + + + MassMono + 198.136828 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00576 + MOD:00912 + PSI-MOD + + + MOD:01279 + crotonaldehyde - site H + + modification from UniMod Other - + + 11283024 + PubMed + + + 1443554 + PubMed + + + 253#H + UniMod + + + + Crotonaldehyde + PSI-MS-label + + + Crotonaldehyde + UniMod-description + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 O 1 + + + + DiffMono + 70.041865 + + + + Formula + C 10 H 13 N 3 O 2 + + + + MassAvg + 207.23 + + + + MassMono + 207.100777 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00576 + MOD:00909 + PSI-MOD + + + MOD:01280 + EDT-iodo-PEO-biotin - site T + + modification from UniMod Chemical derivative - + + 11857757 + PubMed + + + 12175151 + PubMed + + + 118#T + UniMod + + + + EDT-iodo-PEO-biotin + UniMod-description + + + EDT-iodoacetyl-PEO-biotin + PSI-MS-label + + + + DiffAvg + 490.70 + + + + DiffFormula + C 20 H 34 N 4 O 4 S 3 + + + + DiffMono + 490.174219 + + + + Formula + C 24 H 41 N 5 O 6 S 3 + + + + MassAvg + 591.80 + + + + MassMono + 591.221897 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00490 + MOD:00917 + PSI-MOD + + + MOD:01281 + EDT-iodo-PEO-biotin - site S + + modification from UniMod Chemical derivative - + + 16335955 + PubMed + + + 118#S + UniMod + + + + EDT-iodo-PEO-biotin + UniMod-description + + + EDT-iodoacetyl-PEO-biotin + PSI-MS-label + + + + DiffAvg + 490.70 + + + + DiffFormula + C 20 H 34 N 4 O 4 S 3 + + + + DiffMono + 490.174219 + + + + Formula + C 23 H 39 N 5 O 6 S 3 + + + + MassAvg + 577.77 + + + + MassMono + 577.206247 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00490 + MOD:00916 + PSI-MOD + + + MOD:01282 + acrolein addition +56 - site H + + modification from UniMod Other - + + 10825247 + PubMed + + + 15541752 + PubMed + + + 206#H + UniMod + + + + Acrolein addition +56 + UniMod-description + + + Delta:H(4)C(3)O(1) + PSI-MS-label + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + C 9 H 11 N 3 O 2 + + + + MassAvg + 193.21 + + + + MassMono + 193.085127 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00557 + MOD:00909 + PSI-MOD + + + MOD:01283 + acrolein addition +56 - site K + + modification from UniMod Other - + + 10825247 + PubMed + + + 15541752 + PubMed + + + 206#K + UniMod + + + + Acrolein addition +56 + UniMod-description + + + Delta:H(4)C(3)O(1) + PSI-MS-label + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + C 9 H 16 N 2 O 2 + + + + MassAvg + 184.24 + + + + MassMono + 184.121178 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00557 + MOD:00912 + PSI-MOD + + + MOD:01284 + acrolein addition +56 - site C + + modification from UniMod Other - + + 10825247 + PubMed + + + 15541752 + PubMed + + + 9254591 + PubMed + + + 206#C + UniMod + + + + Acrolein addition +56 + UniMod-description + + + Delta:H(4)C(3)O(1) + PSI-MS-label + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + C 6 H 9 N 1 O 2 S 1 + + + + MassAvg + 159.20 + + + + MassMono + 159.035400 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00557 + MOD:00905 + PSI-MOD + + + MOD:01285 + 6x(13)C,1x(15)N labeled L-leucine + + A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 695#L + UniMod + + + + 13C(6) 15N(1) Silac label + UniMod-description + + + Label:13C(6)15N(1) + PSI-MS-label + + + + DiffAvg + 7.02 + + + + DiffFormula + (12)C -6 (13)C 6 (14)N -1 (15)N 1 + + + + DiffMono + 7.017164 + + + + Formula + (13)C 6 H 11 (15)N 1 O 1 + + + + MassAvg + 120.10 + + + + MassMono + 120.101228 + + + + Origin + L + + + + Source + artifact + + + + TermSpec + none + + MOD:00911 + MOD:01370 + PSI-MOD + + + MOD:01286 + 6x(13)C,1x(15)N labeled L-isoleucine + + A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 695#I + UniMod + + + + 13C(6) 15N(1) Silac label + UniMod-description + + + Label:13C(6)15N(1) + PSI-MS-label + + + + DiffAvg + 7.02 + + + + DiffFormula + (12)C -6 (13)C 6 (14)N -1 (15)N 1 + + + + DiffMono + 7.017164 + + + + Formula + (13)C 6 H 11 (15)N 1 O 1 + + + + MassAvg + 120.10 + + + + MassMono + 120.101228 + + + + Origin + I + + + + Source + artifact + + + + TermSpec + none + + MOD:00910 + MOD:01370 + PSI-MOD + + + MOD:01287 + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form - site K + + modification from UniMod Isotopic label - + + 11857757 + PubMed + + + 15602776 + PubMed + + + 364#K + UniMod + + + + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form + UniMod-description + + + ICPL:13C(6) + PSI-MS-label + + + + DiffAvg + 111.04 + + + + DiffFormula + (13)C 6 H 3 N 1 O 1 + + + + DiffMono + 111.041593 + + + + Formula + C 6 (13)C 6 H 15 N 3 O 2 + + + + MassAvg + 239.14 + + + + MassMono + 239.136556 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00789 + MOD:00912 + PSI-MOD + + + MOD:01288 + acetaldehyde +28 - site H + + modification from UniMod Other - + + 255#H + UniMod + + + + Acetaldehyde +28 + UniMod-description + + + Delta:H(4)C(2) + PSI-MS-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 11 N 3 O 1 + + + + MassAvg + 165.20 + + + + MassMono + 165.090212 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00578 + MOD:00909 + PSI-MOD + + + MOD:01289 + acetaldehyde +28 - site K + + modification from UniMod Other - + + 255#K + UniMod + + + + Acetaldehyde +28 + UniMod-description + + + Delta:H(4)C(2) + PSI-MS-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 2 O 1 + + + + MassAvg + 156.23 + + + + MassMono + 156.126263 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00578 + MOD:00912 + PSI-MOD + + + MOD:01290 + dihydroxylated residue - site F + + OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 12686488 + PubMed + + + 9252331 + PubMed + + + 425 + UniMod + + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + + DiffAvg + 32.00 + + + + DiffFormula + O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 9 H 9 N 1 O 3 + + + + MassAvg + 179.17 + + + + MassMono + 179.058243 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01291 + dihydroxylated residue - site W + + OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464. + + 12643539 + PubMed + + + 12686488 + PubMed + + + 6273432 + PubMed + + + 9252331 + PubMed + + + 425 + UniMod + + + + dihydroxy + UniMod-description + + + Dioxidation + PSI-MS-label + + + + DiffAvg + 32.00 + + + + DiffFormula + O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 11 H 10 N 2 O 3 + + + + MassAvg + 218.21 + + + + MassMono + 218.069142 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01292 + dimethylation of proline residue + + OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075. + + 529 + UniMod + + + + Delta:H(5)C(2) + PSI-MS-label + + + Dimethylation of proline residue + UniMod-description + + + + DiffAvg + 29.06 + + + + DiffFormula + C 2 H 5 + + + + DiffMono + 29.039125 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01293 + 1x(18)O labeled deamidated L-asparagine + + A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O. + + 8382902 + PubMed + + + 366#N + UniMod + + + PSI-MOD-slim + + Deamidated:18O(1) + PSI-MS-label + + + Deamidation in presence of O18 + UniMod-description + + + oxy18 + OMSSA-label + + + + DiffAvg + 2.99 + + + + DiffFormula + H -1 N -1 (18)O 1 + + + + DiffMono + 2.988262 + + + + Formula + C 4 H 5 N 1 (16)O 2 (18)O 1 + + + + MassAvg + 117.03 + + + + MassMono + 117.031189 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:00852 + + derives_from + MOD:006840 + + PSI-MOD + + + MOD:01294 + deamidation in presence of O18 -site Q + + OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791. + + 8382902 + PubMed + + + + Deamidated:18O(1) + PSI-MS-label + + + Deamidation in presence of O18 + UniMod-description + + + + DiffAvg + 2.99 + + + + DiffFormula + H -1 N -1 (18)O 1 + + + + DiffMono + 2.988262 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Q + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01295 + monosodium L-aspartate + + A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate. + + 12216740 + PubMed + + + 30#D + UniMod + + + PSI-MOD-slim + + Cation:Na + PSI-MS-label + + + Na1Asp + PSI-MOD-label + + + Sodium adduct + UniMod-description + + + + DiffAvg + 21.98 + + + + DiffFormula + H -1 Na 1 + + + + DiffMono + 21.981944 + + + + Formula + C 4 H 4 N 1 Na 1 O 3 + + + + MassAvg + 137.07 + + + + MassMono + 137.008887 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00423 + MOD:00904 + PSI-MOD + + + MOD:01296 + monosodium L-glutamate + + A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate. + + 12216740 + PubMed + + + 30#E + UniMod + + + PSI-MOD-slim + + Cation:Na + PSI-MS-label + + + MSG + PSI-MOD-alternate + + + Na1Glu + PSI-MOD-label + + + Sodium adduct + UniMod-description + + + + DiffAvg + 21.98 + + + + DiffFormula + H -1 Na 1 + + + + DiffMono + 21.981944 + + + + Formula + C 5 H 6 N 1 Na 1 O 3 + + + + MassAvg + 151.10 + + + + MassMono + 151.024537 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00423 + MOD:00906 + PSI-MOD + + + MOD:01297 + 5x(13)C labeled L-proline + + A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline. + + 12716131 + PubMed + + + 772#P + UniMod + + + In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC. + + 13C(5) Silac label + UniMod-description + + + Label:13C(5) + PSI-MS-label + + + + DiffAvg + 5.02 + + + + DiffFormula + (12)C -5 (13)C 5 + + + + DiffMono + 5.016774 + + + + Formula + (13)C 5 H 7 N 1 O 1 + + + + MassAvg + 102.07 + + + + MassMono + 102.069538 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00915 + MOD:01832 + PSI-MOD + + + MOD:01298 + reduced cysteine 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. + + 11910026 + PubMed + + + 15133838 + PubMed + + + 335#C + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + HNE+Delta:H(2) + PSI-MS-label + + + reduced 4-Hydroxynonenal + UniMod-description + + + + DiffAvg + 158.24 + + + + DiffFormula + C 9 H 18 O 2 + + + + DiffMono + 158.130680 + + + + Formula + C 12 H 23 N 1 O 3 S 1 + + + + MassAvg + 261.38 + + + + MassMono + 261.139865 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00642 + MOD:00905 + + derives_from + MOD:012370 + + PSI-MOD + + + MOD:01299 + reduced lysine 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. + + 11910026 + PubMed + + + 12148805 + PubMed + + + 15133838 + PubMed + + + 335#K + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + HNE+Delta:H(2) + PSI-MS-label + + + reduced 4-Hydroxynonenal + UniMod-description + + + + DiffAvg + 158.24 + + + + DiffFormula + C 9 H 18 O 2 + + + + DiffMono + 158.130680 + + + + Formula + C 15 H 30 N 2 O 3 + + + + MassAvg + 286.42 + + + + MassMono + 286.225643 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00642 + MOD:00912 + + derives_from + MOD:012380 + + PSI-MOD + + + MOD:01300 + reduced histidine 4-hydroxynonenal adduct + + A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. + + 11910026 + PubMed + + + 12148805 + PubMed + + + 15133838 + PubMed + + + 335#H + UniMod + + + 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. + + HNE+Delta:H(2) + PSI-MS-label + + + reduced 4-Hydroxynonenal + UniMod-description + + + + DiffAvg + 158.24 + + + + DiffFormula + C 9 H 18 O 2 + + + + DiffMono + 158.130680 + + + + Formula + C 15 H 25 N 3 O 3 + + + + MassAvg + 295.38 + + + + MassMono + 295.189592 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00642 + MOD:00909 + + derives_from + MOD:012390 + + PSI-MOD + + + MOD:01301 + methylamine Michael addition derivatized threonine + + A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid. + + 11743741 + PubMed + + + 337#T + UniMod + + + In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid. + + Methylamine + PSI-MS-label + + + Michael addition with methylamine + UniMod-description + + + + DiffAvg + 13.04 + + + + DiffFormula + C 1 H 3 N 1 O -1 + + + + DiffMono + 13.031634 + + + + Formula + C 5 H 10 N 2 O 1 + + + + MassAvg + 114.15 + + + + MassMono + 114.079313 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00643 + MOD:00917 + PSI-MOD + + + MOD:01302 + methylamine Michael addition derivatized serine + + A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid. + + 11743741 + PubMed + + + 337#S + UniMod + + + In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid. + + Methylamine + PSI-MS-label + + + Michael addition with methylamine + UniMod-description + + + + DiffAvg + 13.04 + + + + DiffFormula + C 1 H 3 N 1 O -1 + + + + DiffMono + 13.031634 + + + + Formula + C 4 H 8 N 2 O 1 + + + + MassAvg + 100.12 + + + + MassMono + 100.063663 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00643 + MOD:00916 + PSI-MOD + + + MOD:01303 + N4-hexosaminylated asparagine + + A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine. + + 11467524 + PubMed + + + 454#N + UniMod + + + The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG]. + + HexN + PSI-MS-label + + + Hexosamine + UniMod-description + + + + DiffAvg + 161.16 + + + + DiffFormula + C 6 H 11 N 1 O 4 + + + + DiffMono + 161.068808 + + + + Formula + C 10 H 17 N 3 O 6 + + + + MassAvg + 275.26 + + + + MassMono + 275.111735 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:00160 + MOD:00876 + PSI-MOD + + + MOD:01304 + N6-hexosaminylated lysine + + A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group. + + 454#K + UniMod + + + + HexN + PSI-MS-label + + + Hexosamine + UniMod-description + + + + DiffAvg + 161.16 + + + + DiffFormula + C 6 H 11 N 1 O 4 + + + + DiffMono + 161.068808 + + + + Formula + C 12 H 23 N 3 O 5 + + + + MassAvg + 289.33 + + + + MassMono + 289.163771 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00876 + MOD:00912 + PSI-MOD + + + MOD:01305 + N1'-hexosaminylated tryptophan + + A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan. + + 454#W + UniMod + + + The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG]. + + HexN + PSI-MS-label + + + Hexosamine + UniMod-description + + + + DiffAvg + 161.16 + + + + DiffFormula + C 6 H 11 N 1 O 4 + + + + DiffMono + 161.068808 + + + + Formula + C 17 H 21 N 3 O 5 + + + + MassAvg + 347.37 + + + + MassMono + 347.148121 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00876 + MOD:00918 + PSI-MOD + + + MOD:01306 + O-hexosaminylated threonine + + A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine. + + 454#T + UniMod + + + The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG]. + + HexN + PSI-MS-label + + + Hexosamine + UniMod-description + + + + DiffAvg + 161.16 + + + + DiffFormula + C 6 H 11 N 1 O 4 + + + + DiffMono + 161.068808 + + + + Formula + C 10 H 18 N 2 O 6 + + + + MassAvg + 262.26 + + + + MassMono + 262.116486 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00005 + MOD:00876 + PSI-MOD + + + MOD:01307 + thiophosphate labeled with biotin-HPDP -site S + + modification from UniMod Chemical derivative - + + 332#S + UniMod + + + + Thiophos-S-S-biotin + PSI-MS-label + + + thiophosphate labeled with biotin-HPDP + UniMod-description + + + + DiffAvg + 525.66 + + + + DiffFormula + C 19 H 34 N 4 O 5 P 1 S 3 + + + + DiffMono + 525.142895 + + + + Formula + C 22 H 39 N 5 O 7 P 1 S 3 + + + + MassAvg + 612.74 + + + + MassMono + 612.174923 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00639 + MOD:00916 + PSI-MOD + + + MOD:01308 + thiophosphate labeled with biotin-HPDP -site T + + modification from UniMod Chemical derivative - + + 332#T + UniMod + + + + Thiophos-S-S-biotin + PSI-MS-label + + + thiophosphate labeled with biotin-HPDP + UniMod-description + + + + DiffAvg + 525.66 + + + + DiffFormula + C 19 H 34 N 4 O 5 P 1 S 3 + + + + DiffMono + 525.142895 + + + + Formula + C 23 H 41 N 5 O 7 P 1 S 3 + + + + MassAvg + 626.76 + + + + MassMono + 626.190573 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00639 + MOD:00917 + PSI-MOD + + + MOD:01309 + thiophosphate labeled with biotin-HPDP - site Y + + modification from UniMod Chemical derivative - + + 332#Y + UniMod + + + + Thiophos-S-S-biotin + PSI-MS-label + + + thiophosphate labeled with biotin-HPDP + UniMod-description + + + + DiffAvg + 525.66 + + + + DiffFormula + C 19 H 34 N 4 O 5 P 1 S 3 + + + + DiffMono + 525.142895 + + + + Formula + C 28 H 43 N 5 O 7 P 1 S 3 + + + + MassAvg + 688.83 + + + + MassMono + 688.206223 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00639 + MOD:00919 + PSI-MOD + + + MOD:01310 + quaternary amine labeling reagent light form N6-L-lysine + + A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group. + + 11857757 + PubMed + + + 60#K + UniMod + + + + GIST-Quat + PSI-MS-label + + + Quaternary amine labeling reagent light form (N-term & K) + UniMod-description + + + + DiffAvg + 59.07 + + + + DiffFormula + C 3 (1)H 9 N 1 + + + + DiffMono + 59.073499 + + + + Formula + C 9 (1)H 21 N 3 O 1 + + + + MassAvg + 187.17 + + + + MassMono + 187.168462 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01426 + PSI-MOD + + + MOD:01311 + quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine + + A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group. + + 11698400 + PubMed + + + 11857757 + PubMed + + + 11914093 + PubMed + + + 61#K + UniMod + + + + GIST-Quat:2H(3) + PSI-MS-label + + + Quaternary amine labeling reagent heavy (+3amu) form, N-term & K + UniMod-description + + + + DiffAvg + 62.09 + + + + DiffFormula + C 3 (1)H 6 (2)H 3 N 1 + + + + DiffMono + 62.092330 + + + + Formula + C 9 (1)H 18 (2)H 3 N 3 O 1 + + + + MassAvg + 190.19 + + + + MassMono + 190.187293 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01426 + PSI-MOD + + + MOD:01312 + quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine + + A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group. + + 11857757 + PubMed + + + 62#K + UniMod + + + Apparently incorrect parent [JSG]. + + GIST-Quat:2H(6) + PSI-MS-label + + + Quaternary amine labeling reagent heavy form (+6amu), N-term & K + UniMod-description + + + + DiffAvg + 65.11 + + + + DiffFormula + C 3 (1)H 3 (2)H 6 N 1 + + + + DiffMono + 65.111160 + + + + Formula + C 9 (1)H 15 (2)H 6 N 3 O 1 + + + + MassAvg + 193.21 + + + + MassMono + 193.206123 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01426 + PSI-MOD + + + MOD:01313 + quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine + + A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group. + + 11857757 + PubMed + + + 63#K + UniMod + + + + GIST-Quat:2H(9) + PSI-MS-label + + + Quaternary amine labeling reagent heavy form (+9amu), N-term & K + UniMod-description + + + + DiffAvg + 68.13 + + + + DiffFormula + C 3 (2)H 9 N 1 + + + + DiffMono + 68.129990 + + + + Formula + C 9 (1)H 12 (2)H 9 N 3 O 1 + + + + MassAvg + 196.22 + + + + MassMono + 196.224953 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01426 + PSI-MOD + + + MOD:01314 + 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 12716131 + PubMed + + + 64#K + UniMod + + + + Succinic anhydride labeling reagent light form (K) + UniMod-description + + + Succinyl + PSI-MS-label + + + + DiffAvg + 100.02 + + + + DiffFormula + (12)C 4 (1)H 4 O 3 + + + + DiffMono + 100.016044 + + + + Formula + (12)C 10 H 16 N 2 O 4 + + + + MassAvg + 228.11 + + + + MassMono + 228.111007 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01819 + PSI-MOD + + + MOD:01315 + 4x(2)H labeled N6-succinyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine. + + 11344537 + PubMed + + + 11857757 + PubMed + + + 12175151 + PubMed + + + 15189151 + PubMed + + + 65#K + UniMod + + + + Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K + UniMod-description + + + Succinyl:2H(4) + PSI-MS-label + + + + DiffAvg + 104.04 + + + + DiffFormula + C 4 (2)H 4 O 3 + + + + DiffMono + 104.041151 + + + + Formula + C 10 (1)H 12 (2)H 4 N 2 O 4 + + + + MassAvg + 232.14 + + + + MassMono + 232.136114 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01819 + PSI-MOD + + + MOD:01316 + 4x(13)C labeled N6-succinyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine. + + 11344537 + PubMed + + + 11857757 + PubMed + + + 12175151 + PubMed + + + 15189151 + PubMed + + + 66#K + UniMod + + + + Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), K + UniMod-description + + + Succinyl:13C(4) + PSI-MS-label + + + + DiffAvg + 104.03 + + + + DiffFormula + (13)C 4 H 4 O 3 + + + + DiffMono + 104.029463 + + + + Formula + (12)C 6 (13)C 4 H 16 N 2 O 4 + + + + MassAvg + 232.12 + + + + MassMono + 232.124426 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01819 + PSI-MOD + + + MOD:01317 + phosphorylation to amine thiol - site T + + modification from UniMod Chemical derivative - + + 12216740 + PubMed + + + 178#T + UniMod + + + + DAET + PSI-MS-label + + + phosphorylation to amine thiol + UniMod-description + + + + DiffAvg + 87.18 + + + + DiffFormula + C 4 H 9 N 1 O -1 S 1 + + + + DiffMono + 87.050656 + + + + Formula + C 8 H 16 N 2 O 1 S 1 + + + + MassAvg + 188.29 + + + + MassMono + 188.098334 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00535 + MOD:00917 + PSI-MOD + + + MOD:01318 + phosphorylation to amine thiol - site S + + modification from UniMod Chemical derivative - + + 11510821 + PubMed + + + 12216740 + PubMed + + + 12422359 + PubMed + + + 178#S + UniMod + + + + DAET + PSI-MS-label + + + phosphorylation to amine thiol + UniMod-description + + + + DiffAvg + 87.18 + + + + DiffFormula + C 4 H 9 N 1 O -1 S 1 + + + + DiffMono + 87.050656 + + + + Formula + C 7 H 14 N 2 O 1 S 1 + + + + MassAvg + 174.26 + + + + MassMono + 174.082684 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00535 + MOD:00916 + PSI-MOD + + + MOD:01319 + Michael addition of BHT quinone methide to histidine + + modification from UniMod Other + + 11510821 + PubMed + + + 12422359 + PubMed + + + 9448752 + PubMed + + + 176#H + UniMod + + + Secondary adduct, much less common than cysteine. [UniMod] + + BHT + PSI-MS-label + + + Michael addition of BHT quinone methide to Cysteine and Lysine + UniMod-description + + + + DiffAvg + 218.34 + + + + DiffFormula + C 15 H 22 O 1 + + + + DiffMono + 218.167065 + + + + Formula + C 21 H 29 N 3 O 2 + + + + MassAvg + 355.48 + + + + MassMono + 355.225977 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00534 + MOD:00909 + PSI-MOD + + + MOD:01320 + Michael addition of BHT quinone methide to lysine + + modification from UniMod Other + + 16078144 + PubMed + + + 9448752 + PubMed + + + 176#K + UniMod + + + Secondary adduct, much less common than cysteine. [UniMod] + + BHT + PSI-MS-label + + + Michael addition of BHT quinone methide to Cysteine and Lysine + UniMod-description + + + + DiffAvg + 218.34 + + + + DiffFormula + C 15 H 22 O 1 + + + + DiffMono + 218.167065 + + + + Formula + C 21 H 34 N 2 O 2 + + + + MassAvg + 346.51 + + + + MassMono + 346.262028 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00534 + MOD:00912 + PSI-MOD + + + MOD:01321 + Michael addition of BHT quinone methide to cysteine + + modification from UniMod Other + + 11510821 + PubMed + + + 12422359 + PubMed + + + 9448752 + PubMed + + + 176#C + UniMod + + + Primary adduct formed. [UniMod] + + BHT + PSI-MS-label + + + Michael addition of BHT quinone methide to Cysteine and Lysine + UniMod-description + + + + DiffAvg + 218.34 + + + + DiffFormula + C 15 H 22 O 1 + + + + DiffMono + 218.167065 + + + + Formula + C 18 H 27 N 1 O 2 S 1 + + + + MassAvg + 321.48 + + + + MassMono + 321.176250 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00534 + MOD:00905 + PSI-MOD + + + MOD:01322 + propionaldehyde +40 - site K + + modification from UniMod Other - + + 15549660 + PubMed + + + 256#K + UniMod + + + + Delta:H(4)C(3) + PSI-MS-label + + + Propionaldehyde +40 + UniMod-description + + + + DiffAvg + 40.06 + + + + DiffFormula + C 3 H 4 + + + + DiffMono + 40.031300 + + + + Formula + C 9 H 16 N 2 O 1 + + + + MassAvg + 168.24 + + + + MassMono + 168.126263 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00579 + MOD:00912 + PSI-MOD + + + MOD:01323 + propionaldehyde +40 - site H + + modification from UniMod Other - + + 256#H + UniMod + + + + Delta:H(4)C(3) + PSI-MS-label + + + Propionaldehyde +40 + UniMod-description + + + + DiffAvg + 40.06 + + + + DiffFormula + C 3 H 4 + + + + DiffMono + 40.031300 + + + + Formula + C 9 H 11 N 3 O 1 + + + + MassAvg + 177.21 + + + + MassMono + 177.090212 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00579 + MOD:00909 + PSI-MOD + + + MOD:01324 + acetaldehyde +26 - site H + + modification from UniMod Other - + + 7744761 + PubMed + + + 254#H + UniMod + + + + Acetaldehyde +26 + UniMod-description + + + Delta:H(2)C(2) + PSI-MS-label + + + + DiffAvg + 26.04 + + + + DiffFormula + C 2 H 2 + + + + DiffMono + 26.015650 + + + + Formula + C 8 H 9 N 3 O 1 + + + + MassAvg + 163.18 + + + + MassMono + 163.074562 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00577 + MOD:00909 + PSI-MOD + + + MOD:01325 + acetaldehyde +26 - site K + + modification from UniMod Other - + + 7744761 + PubMed + + + 254#K + UniMod + + + + Acetaldehyde +26 + UniMod-description + + + Delta:H(2)C(2) + PSI-MS-label + + + + DiffAvg + 26.04 + + + + DiffFormula + C 2 H 2 + + + + DiffMono + 26.015650 + + + + Formula + C 8 H 14 N 2 O 1 + + + + MassAvg + 154.21 + + + + MassMono + 154.110613 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00577 + MOD:00912 + PSI-MOD + + + MOD:01326 + 9x(13)C labeled L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine. + + 11510821 + PubMed + + + 12422359 + PubMed + + + 12716131 + PubMed + + + 184#Y + UniMod + + + + 13C(9) Silac label + UniMod-description + + + Label:13C(9) + PSI-MS-label + + + + DiffAvg + 9.03 + + + + DiffFormula + (12)C -9 (13)C 9 + + + + DiffMono + 9.030194 + + + + Formula + (13)C 9 H 9 N 1 O 2 + + + + MassAvg + 172.09 + + + + MassMono + 172.093522 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00540 + MOD:00919 + PSI-MOD + + + MOD:01327 + 9x(13)C labeled L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine. + + 12716131 + PubMed + + + 184#F + UniMod + + + + 13C(9) Silac label + UniMod-description + + + Label:13C(9) + PSI-MS-label + + + + DiffAvg + 9.03 + + + + DiffFormula + (12)C -9 (13)C 9 + + + + DiffMono + 9.030194 + + + + Formula + (13)C 9 H 9 N 1 O 1 + + + + MassAvg + 156.10 + + + + MassMono + 156.098607 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00540 + MOD:00914 + PSI-MOD + + + MOD:01328 + iodoacetic acid - site W + + modification from UniMod Chemical derivative - hydroxylethanone + + 17525468 + PubMed + + + 6#W + UniMod + + + There is no citation for this UniMod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG]. + + Carboxymethyl + PSI-MS-label + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + C 13 H 12 N 2 O 3 + + + + MassAvg + 244.25 + + + + MassMono + 244.084792 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00399 + MOD:00918 + PSI-MOD + + + MOD:01329 + iodoacetic acid - site C + + OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 + + 197 + DeltaMass + + + Modification from UniMod Chemical derivative, UniMod:6 site C + + Carboxymethyl + PSI-MS-label + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01330 + iodoacetic acid -site K + + OBSOLETE because identical with MOD:01094. Remap to MOD:01094 + + 18688235 + PubMed + + + a modification from UniMod:6 + + Carboxymethyl + PSI-MS-label + + + Iodoacetic acid derivative + UniMod-description + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 O 2 + + + + DiffMono + 58.005479 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01331 + 6x(13)C labeled L-arginine + + A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine. + + 12716131 + PubMed + + + 188#R + UniMod + + + PSI-MOD-slim + + 13C(6) Silac label + UniMod-description + + + arg-13c6 + OMSSA-label + + + Label:13C(6) + PSI-MS-label + + + + DiffAvg + 6.02 + + + + DiffFormula + (12)C -6 (13)C 6 + + + + DiffMono + 6.020129 + + + + Formula + (13)C 6 H 12 N 4 O 1 + + + + MassAvg + 162.12 + + + + MassMono + 162.121240 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00544 + PSI-MOD + + + MOD:01332 + 6x(13)C labeled L-leucine + + A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine. + + 12716131 + PubMed + + + 188#L + UniMod + + + PSI-MOD-slim + + 13C(6) Silac label + UniMod-description + + + Label:13C(6) + PSI-MS-label + + + + DiffAvg + 6.02 + + + + DiffFormula + (12)C -6 (13)C 6 + + + + DiffMono + 6.020129 + + + + Formula + (13)C 6 H 11 N 1 O 1 + + + + MassAvg + 119.10 + + + + MassMono + 119.104193 + + + + Origin + L + + + + Source + artifact + + + + TermSpec + none + + MOD:00544 + PSI-MOD + + + MOD:01333 + 6x(13)C labeled L-isoleucine + + A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine. + + 12716131 + PubMed + + + 12766232 + PubMed + + + 188#I + UniMod + + + PSI-MOD-slim + + 13C(6) Silac label + UniMod-description + + + Label:13C(6) + PSI-MS-label + + + + DiffAvg + 6.02 + + + + DiffFormula + (12)C -6 (13)C 6 + + + + DiffMono + 6.020129 + + + + Formula + (13)C 6 H 11 N 1 O 1 + + + + MassAvg + 119.10 + + + + MassMono + 119.104193 + + + + Origin + I + + + + Source + artifact + + + + TermSpec + none + + MOD:00544 + PSI-MOD + + + MOD:01334 + 6x(13)C labeled L-lysine + + A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 12716131 + PubMed + + + 188#K + UniMod + + + PSI-MOD-slim + + 13C(6) Silac label + UniMod-description + + + Label:13C(6) + PSI-MS-label + + + lys-13c6 + OMSSA-label + + + + DiffAvg + 6.02 + + + + DiffFormula + (12)C -6 (13)C 6 + + + + DiffMono + 6.020129 + + + + Formula + (13)C 6 H 12 N 2 O 1 + + + + MassAvg + 134.12 + + + + MassMono + 134.115092 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00544 + PSI-MOD + + + MOD:01335 + 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized lysine + + modification from UniMod Chemical derivative - + + 11467524 + PubMed + + + 16526082 + PubMed + + + 464#K + UniMod + + + + 4-sulfophenyl isothiocyanate (Heavy C13) + UniMod-description + + + SPITC:13C(6) + PSI-MS-label + + + + DiffAvg + 220.99 + + + + DiffFormula + (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 + + + + DiffMono + 220.991214 + + + + Formula + (12)C 7 (13)C 6 H 17 N 3 O 4 S 2 + + + + MassAvg + 349.09 + + + + MassMono + 349.086177 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00880 + MOD:00912 + PSI-MOD + + + MOD:01336 + deamidation followed by a methylation -site Q + + OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657. + + 18688235 + PubMed + + + Modification from UniMod Post-translational - UniMod:528. + + Deamidation followed by a methylation + UniMod-description + + + Methyl+Deamidated + PSI-MS-label + + + + DiffAvg + 15.01 + + + + DiffFormula + C 1 H 1 N -1 O 1 + + + + DiffMono + 14.999666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01337 + deamidated 4-methyl esterified asparagine + + A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester. + + 528#N + UniMod + + + The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG]. + + Deamidation followed by a methylation + UniMod-description + + + Methyl+Deamidated + PSI-MS-label + + + + DiffAvg + 15.01 + + + + DiffFormula + C 1 H 1 N -1 O 1 + + + + DiffMono + 14.999666 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + N + + + + Source + artifact + + + + TermSpec + none + + MOD:01181 + MOD:01369 + PSI-MOD + + + MOD:01338 + N6-ethyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine. + + 9629898 + PubMed + + + 280#K + UniMod + + + The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. + + Ethyl + PSI-MS-label + + + Ethylation + UniMod-description + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 2 O 1 + + + + MassAvg + 156.23 + + + + MassMono + 156.126263 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00912 + MOD:01339 + PSI-MOD + + + MOD:01339 + ethylated residue + + A protein modification that effectively replaces a hydrogen atom with an ethyl group. + + 9629898 + PubMed + + + 280 + UniMod + + + From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. + + Ethyl + PSI-MS-label + + + Ethylation + UniMod-description + + + EtRes + PSI-MOD-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00001 + PSI-MOD + + + MOD:01340 + ESP-Tag heavy d10 - site K + + modification from UniMod Isotopic label - + + 11078590 + PubMed + + + 11085420 + PubMed + + + 11821862 + PubMed + + + 91#K + UniMod + + + + ESP-Tag heavy d10 + UniMod-description + + + ESP:2H(10) + PSI-MS-label + + + + DiffAvg + 348.24 + + + + DiffFormula + C 16 (1)H 16 (2)H 10 N 4 O 2 S 1 + + + + DiffMono + 348.240415 + + + + Formula + C 22 (1)H 28 (2)H 10 N 6 O 3 S 1 + + + + MassAvg + 476.34 + + + + MassMono + 476.335378 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00469 + MOD:00912 + PSI-MOD + + + MOD:01341 + ESP-Tag light d0 - site K + + modification from UniMod Isotopic label - + + 90#K + UniMod + + + + ESP + PSI-MS-label + + + ESP-Tag light d0 + UniMod-description + + + + DiffAvg + 338.47 + + + + DiffFormula + C 16 H 26 N 4 O 2 S 1 + + + + DiffMono + 338.177647 + + + + Formula + C 22 H 38 N 6 O 3 S 1 + + + + MassAvg + 466.64 + + + + MassMono + 466.272610 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00468 + MOD:00912 + PSI-MOD + + + MOD:01342 + selenium substitution for sulfur - site M + + OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530. + + 12148805 + PubMed + + + 162 + UniMod + + + + Delta:S(-1)Se(1) + PSI-MS-label + + + Selenium replaces sulphur + UniMod-description + + + + DiffAvg + 46.91 + + + + DiffFormula + S -1 Se 1 + + + + DiffMono + 47.944450 + + + + Formula + C 5 H 9 N 1 O 1 S 0 Se 1 + + + + MassAvg + 178.10 + + + + MassMono + 178.984935 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01343 + selenium substitution for sulfur - site C + + OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686. + + 12148805 + PubMed + + + 162 + UniMod + + + + Delta:S(-1)Se(1) + PSI-MS-label + + + Selenium replaces sulphur + UniMod-description + + + + DiffAvg + 46.91 + + + + DiffFormula + S -1 Se 1 + + + + DiffMono + 47.944450 + + + + Formula + C 3 H 5 N 1 O 1 S 0 Se 1 + + + + MassAvg + 150.05 + + + + MassMono + 150.953635 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01344 + dehydrogenated residue - site S + + OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835. + + 9252331 + PubMed + + + 9276974 + PubMed + + + 401 + UniMod + + + + 2-amino-3-oxo-butanoic_acid + UniMod-description + + + Didehydro + PSI-MS-label + + + + DiffAvg + -2.02 + + + + DiffFormula + H -2 + + + + DiffMono + -2.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01345 + 2-amino-3-oxobutanoic acid + + A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid. + + 12716131 + PubMed + + + 9252331 + PubMed + + + 401#T + UniMod + + + There is no citation for this modification in the UniMod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG]. + + 2-amino-3-ketobutyric acid + PSI-MOD-alternate + + + 2-amino-3-oxo-butanoic_acid + UniMod-description + + + 3-ketobutyrine + PSI-MOD-alternate + + + Didehydro + PSI-MS-label + + + twoamino3oxobutanoicacid + OMSSA-label + + + + DiffAvg + -2.02 + + + + DiffFormula + H -2 + + + + DiffMono + -2.015650 + + + + Formula + C 4 H 5 N 1 O 2 + + + + MassAvg + 99.09 + + + + MassMono + 99.032028 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01888 + PSI-MOD + + + MOD:01346 + N4-hexosylated asparagine + + A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine. + + 11112526 + PubMed + + + 11567090 + PubMed + + + 15279557 + PubMed + + + 6540775 + PubMed + + + 41#N + UniMod + + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 10 H 16 N 2 O 7 + + + + MassAvg + 276.25 + + + + MassMono + 276.095751 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00160 + MOD:00434 + PSI-MOD + + + MOD:01347 + hexose glycated L-lysine + + A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct. + + 0 + DeltaMass + + + 15279557 + PubMed + + + 41#K + UniMod + + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 12 H 22 N 2 O 6 + + + + MassAvg + 290.32 + + + + MassMono + 290.147786 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00767 + MOD:00912 + PSI-MOD + + + MOD:01348 + O-hexosylated threonine + + A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine. + + 15279557 + PubMed + + + 8597590 + PubMed + + + 41#T + UniMod + + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + + DiffAvg + 162.14 + + + + DiffFormula + C 6 H 10 O 5 + + + + DiffMono + 162.052823 + + + + Formula + C 10 H 17 N 1 O 7 + + + + MassAvg + 263.25 + + + + MassMono + 263.100502 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00005 + MOD:00434 + PSI-MOD + + + MOD:01349 + hydrolyzed N-ethylmaleimide cysteine adduct + + modification from UniMod Chemical derivative - + + 320#C + UniMod + + + Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. + + Nethylmaleimide+water + PSI-MS-label + + + Nethylmaleimidehydrolysis + UniMod-description + + + + DiffAvg + 143.14 + + + + DiffFormula + C 6 H 9 N 1 O 3 + + + + DiffMono + 143.058243 + + + + Formula + C 9 H 14 N 2 O 4 S 1 + + + + MassAvg + 246.28 + + + + MassMono + 246.067428 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00631 + MOD:00905 + PSI-MOD + + + MOD:01350 + hydrolyzed N-ethylmaleimide lysine adduct + + modification from UniMod Chemical derivative - + + 320#K + UniMod + + + Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. + + Nethylmaleimide+water + PSI-MS-label + + + Nethylmaleimidehydrolysis + UniMod-description + + + + DiffAvg + 143.14 + + + + DiffFormula + C 6 H 9 N 1 O 3 + + + + DiffMono + 143.058243 + + + + Formula + C 12 H 21 N 3 O 4 + + + + MassAvg + 271.32 + + + + MassMono + 271.153206 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00631 + PSI-MOD + + + MOD:01351 + nitrated L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan. + + 8839040 + PubMed + + + 9252331 + PubMed + + + 354#W + UniMod + + + One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. + + Nitro + PSI-MS-label + + + nitrow + OMSSA-label + + + Oxidation to nitro + UniMod-description + + + + DiffAvg + 45.00 + + + + DiffFormula + H -1 N 1 O 2 + + + + DiffMono + 44.985078 + + + + Formula + C 11 H 9 N 3 O 3 + + + + MassAvg + 231.21 + + + + MassMono + 231.064391 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00461 + MOD:00918 + PSI-MOD + + + MOD:01352 + nitrated L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine. + + 14678012 + PubMed + + + 8839040 + PubMed + + + 9252331 + PubMed + + + 354#Y + UniMod + + + One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. + PSI-MOD-slim + + Nitro + PSI-MS-label + + + nitroy + OMSSA-label + + + Oxidation to nitro + UniMod-description + + + + DiffAvg + 45.00 + + + + DiffFormula + H -1 N 1 O 2 + + + + DiffMono + 44.985078 + + + + Formula + C 9 H 8 N 2 O 4 + + + + MassAvg + 208.17 + + + + MassMono + 208.048407 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00461 + MOD:00919 + PSI-MOD + + + MOD:01353 + amidination of lysines or N-terminal amines with methyl acetimidate - site K + + modification from UniMod Chemical derivative - + + 12643539 + PubMed + + + 15602776 + PubMed + + + 6273432 + PubMed + + + 141#K + UniMod + + + + amidination of lysines or N-terminal amines with methyl acetimidate + UniMod-description + + + Amidine + PSI-MS-label + + + + DiffAvg + 41.05 + + + + DiffFormula + C 2 H 3 N 1 + + + + DiffMono + 41.026549 + + + + Formula + C 8 H 15 N 3 O 1 + + + + MassAvg + 169.23 + + + + MassMono + 169.121512 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00509 + MOD:00912 + PSI-MOD + + + MOD:01354 + Hex1HexNAc1NeuAc1 N4-glycosylated asparagine + + A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. + + 11698400 + PubMed + + + 149#N + UniMod + + + + Hex(1)HexNAc(1)NeuAc(1) + PSI-MS-label + + + Hex1HexNAc1NeuAc1 + UniMod-description + + + + DiffAvg + 657.60 + + + + DiffFormula + C 25 H 41 N 2 O 18 + + + + DiffMono + 657.235437 + + + + Formula + C 29 H 47 N 4 O 20 + + + + MassAvg + 771.70 + + + + MassMono + 771.278365 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00517 + MOD:00903 + PSI-MOD + + + MOD:01355 + Hex1HexNAc1NeuAc1O-glycosylated threonine + + A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. + + 149#T + UniMod + + + + Hex(1)HexNAc(1)NeuAc(1) + PSI-MS-label + + + Hex1HexNAc1NeuAc1 + UniMod-description + + + + DiffAvg + 657.60 + + + + DiffFormula + C 25 H 41 N 2 O 18 + + + + DiffMono + 657.235437 + + + + Formula + C 29 H 48 N 3 O 20 + + + + MassAvg + 758.70 + + + + MassMono + 758.283116 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00517 + MOD:00917 + PSI-MOD + + + MOD:01356 + Hex1HexNAc1NeuAc1 O-glycosylated serine + + A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. + + 7856876 + PubMed + + + 149#S + UniMod + + + + Hex(1)HexNAc(1)NeuAc(1) + PSI-MS-label + + + Hex1HexNAc1NeuAc1 + UniMod-description + + + + DiffAvg + 657.60 + + + + DiffFormula + C 25 H 41 N 2 O 18 + + + + DiffMono + 657.235437 + + + + Formula + C 28 H 46 N 3 O 20 + + + + MassAvg + 744.68 + + + + MassMono + 744.267466 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00517 + MOD:00916 + PSI-MOD + + + MOD:01357 + 2x(13)C,4x(2)H labeled dimethylated L-lysine + + A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine. + + 12686488 + PubMed + + + 16335955 + PubMed + + + 510#K + UniMod + + + + DiMethyl-C13HD2 + UniMod-description + + + Dimethyl:2H(4)13C(2) + PSI-MS-label + + + + DiffAvg + 34.06 + + + + DiffFormula + (13)C 2 (2)H 4 + + + + DiffMono + 34.063117 + + + + Formula + (12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1 + + + + MassAvg + 162.16 + + + + MassMono + 162.158080 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:00927 + + derives_from + MOD:000840 + + PSI-MOD + + + MOD:01358 + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site N-term + + modification from UniMod Isotopic label - Use when labelling post-digest + + 15602776 + PubMed + + + 687#N-term + UniMod + + + + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form + UniMod-description + + + ICPL:2H(4) + PSI-MS-label + + + + DiffAvg + 109.05 + + + + DiffFormula + C 6 (1)H -1 (2)H 4 N 1 O 1 + + + + DiffMono + 109.046571 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01426 + PSI-MOD + + + MOD:01359 + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site K + + modification from UniMod Isotopic label - Use when labelling post-digest + + 15602776 + PubMed + + + 687#K + UniMod + + + + Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form + UniMod-description + + + ICPL:2H(4) + PSI-MS-label + + + + DiffAvg + 109.05 + + + + DiffFormula + C 6 (1)H -1 (2)H 4 N 1 O 1 + + + + DiffMono + 109.046571 + + + + Formula + C 12 (1)H 11 (2)H 4 N 3 O 2 + + + + MassAvg + 237.14 + + + + MassMono + 237.141534 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01426 + PSI-MOD + + + MOD:01360 + 4-sulfophenyl isothiocyanate N6-derivatized lysine + + A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine. + + 14689565 + PubMed + + + 14745769 + PubMed + + + 15549660 + PubMed + + + 16526082 + PubMed + + + 261#K + UniMod + + + + 4-sulfophenyl isothiocyanate + UniMod-description + + + N6-[(4-sulfophenyl)carbamothioyl]lysine + PSI-MOD-alternate + + + SPITC + PSI-MS-label + + + + DiffAvg + 215.24 + + + + DiffFormula + C 7 H 5 N 1 O 3 S 2 + + + + DiffMono + 214.971085 + + + + Formula + C 13 H 17 N 3 O 4 S 2 + + + + MassAvg + 343.42 + + + + MassMono + 343.066048 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00584 + MOD:00912 + PSI-MOD + + + MOD:01361 + O-thiophospho-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine. + + 11507762 + PubMed + + + 12110917 + PubMed + + + 260#T + UniMod + + + + Thiophospho + PSI-MS-label + + + Thiophosphorylation + UniMod-description + + + + DiffAvg + 96.04 + + + + DiffFormula + H 1 O 2 P 1 S 1 + + + + DiffMono + 95.943487 + + + + Formula + C 4 H 8 N 1 O 4 P 1 S 1 + + + + MassAvg + 197.14 + + + + MassMono + 196.991165 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00583 + MOD:00917 + PSI-MOD + + + MOD:01362 + O-thiophospho-L-serine + + A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine. + + 11507762 + PubMed + + + 12110917 + PubMed + + + 260#S + UniMod + + + + Thiophospho + PSI-MS-label + + + Thiophosphorylation + UniMod-description + + + + DiffAvg + 96.04 + + + + DiffFormula + H 1 O 2 P 1 S 1 + + + + DiffMono + 95.943487 + + + + Formula + C 3 H 6 N 1 O 4 P 1 S 1 + + + + MassAvg + 183.12 + + + + MassMono + 182.975515 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00583 + MOD:00916 + PSI-MOD + + + MOD:01363 + O4'-thiophospho-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine. + + 12110917 + PubMed + + + 15549660 + PubMed + + + 260#Y + UniMod + + + + Thiophospho + PSI-MS-label + + + Thiophosphorylation + UniMod-description + + + + DiffAvg + 96.04 + + + + DiffFormula + H 1 O 2 P 1 S 1 + + + + DiffMono + 95.943487 + + + + Formula + C 9 H 10 N 1 O 4 P 1 S 1 + + + + MassAvg + 259.22 + + + + MassMono + 259.006815 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00583 + MOD:00919 + PSI-MOD + + + MOD:01364 + fluorescein-5-thiosemicarbazide - site S + + modification from UniMod Chemical derivative - + + 11467524 + PubMed + + + 478#S + UniMod + + + + fluorescein-5-thiosemicarbazide + UniMod-description + + + FTC + PSI-MS-label + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + C 24 H 20 N 4 O 7 S 1 + + + + MassAvg + 508.51 + + + + MassMono + 508.105270 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00626 + MOD:00916 + PSI-MOD + + + MOD:01365 + fluorescein-5-thiosemicarbazide - site C + + modification from UniMod Chemical derivative - + + 478#C + UniMod + + + + fluorescein-5-thiosemicarbazide + UniMod-description + + + FTC + PSI-MS-label + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + C 24 H 20 N 4 O 6 S 2 + + + + MassAvg + 524.57 + + + + MassMono + 524.082426 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00626 + MOD:00905 + PSI-MOD + + + MOD:01366 + fluorescein-5-thiosemicarbazide - site K + + modification from UniMod Chemical derivative - + + 478#K + UniMod + + + + fluorescein-5-thiosemicarbazide + UniMod-description + + + FTC + PSI-MS-label + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + C 27 H 27 N 5 O 6 S 1 + + + + MassAvg + 549.60 + + + + MassMono + 549.168205 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00626 + MOD:00912 + PSI-MOD + + + MOD:01367 + fluorescein-5-thiosemicarbazide - site P + + modification from UniMod Chemical derivative - + + 478#P + UniMod + + + + fluorescein-5-thiosemicarbazide + UniMod-description + + + FTC + PSI-MS-label + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + C 26 H 22 N 4 O 6 S 1 + + + + MassAvg + 518.54 + + + + MassMono + 518.126005 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00626 + MOD:00915 + PSI-MOD + + + MOD:01368 + fluorescein-5-thiosemicarbazide - site R + + modification from UniMod Chemical derivative - + + 15525938 + PubMed + + + 478#R + UniMod + + + + fluorescein-5-thiosemicarbazide + UniMod-description + + + FTC + PSI-MS-label + + + + DiffAvg + 421.43 + + + + DiffFormula + C 21 H 15 N 3 O 5 S 1 + + + + DiffMono + 421.073242 + + + + Formula + C 27 H 27 N 7 O 6 S 1 + + + + MassAvg + 577.62 + + + + MassMono + 577.174353 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00626 + MOD:00902 + PSI-MOD + + + MOD:01369 + deamidated and methyl esterified residue + + A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group. + + 528 + UniMod + + + PSI-MOD-slim + + Deamidation followed by a methylation + UniMod-description + + + Methyl+Deamidated + PSI-MS-label + + + + DiffAvg + 15.01 + + + + DiffFormula + C 1 H 1 N -1 O 1 + + + + DiffMono + 14.999666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00393 + MOD:00400 + PSI-MOD + + + MOD:01370 + 6x(13)C,1x(15)N labeled residue + + A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 695 + UniMod + + + + 13C(6) 15N(1) Silac label + UniMod-description + + + Label:13C(6)15N(1) + PSI-MS-label + + + + DiffAvg + 7.02 + + + + DiffFormula + (12)C -6 (13)C 6 (14)N -1 (15)N 1 + + + + DiffMono + 7.017164 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + MOD:00843 + PSI-MOD + + + MOD:01371 + deamidation in presence of O18 + + OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851. + + 8382902 + PubMed + + + + Deamidated:18O(1) + PSI-MS-label + + + Deamidation in presence of O18 + UniMod-description + + + + DiffAvg + 2.99 + + + + DiffFormula + H -1 N -1 (18)O 1 + + + + DiffMono + 2.988262 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01372 + (2S)-4-hydroxyleucine + + A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine. + + 363352 + PubMed + + + 9164839 + PubMed + + + AA0442 + RESID + + + + (2S)-2-amino-4-hydroxy-4-methylpentanoic acid + RESID-systematic + + + (2S)-4-hydroxyleucine + RESID-name + + + gamma-hydroxyleucine + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 11 N 1 O 2 + + + + MassAvg + 129.16 + + + + MassMono + 129.078979 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:01411 + PSI-MOD + + + MOD:01373 + (2S,4R)-5-hydroxyleucine + + A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine. + + 16858410 + PubMed + + + 7690768 + PubMed + + + 9164839 + PubMed + + + AA0443 + RESID + + + + (2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid + RESID-systematic + + + (2S,4R)-5-hydroxyleucine + RESID-name + + + (4R)-5-hydroxyleucine + RESID-alternate + + + delta-hydroxyleucine + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 11 N 1 O 2 + + + + MassAvg + 129.16 + + + + MassMono + 129.078979 + + + + Origin + L + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01411 + PSI-MOD + + + MOD:01374 + (2S,4R)-5-oxoleucine + + A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine. + + 43739 + ChEBI + + + 16858410 + PubMed + + + AA0444 + RESID + + + + (2S,4R)-2-amino-4-methyl-5-oxopentanoic acid + RESID-systematic + + + (2S,4R)-5-oxoleucine + RESID-name + + + (4R)-5-oxo-L-leucine + RESID-alternate + + + + DiffAvg + 13.98 + + + + DiffFormula + C 0 H -2 N 0 O 1 + + + + DiffMono + 13.979265 + + + + Formula + C 6 H 9 N 1 O 2 + + + + MassAvg + 127.14 + + + + MassMono + 127.063329 + + + + Origin + L + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00679 + MOD:00911 + PSI-MOD + + + MOD:01375 + (2S,4R)-4,5-dihydroxyleucine + + A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine. + + 6010785 + PubMed + + + 6893271 + PubMed + + + AA0445 + RESID + + + + (2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid + RESID-systematic + + + (2S,4R)-4,5-dihydroxyleucine + RESID-name + + + (4R)-4,5-dihydroxyleucine + RESID-alternate + + + gamma,delta-dihydroxyleucine + RESID-alternate + + + MOD_RES (4R)-4,5-dihydroxyleucine + UniProt-feature + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 11 N 1 O 3 + + + + MassAvg + 145.16 + + + + MassMono + 145.073893 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:01412 + PSI-MOD + + + MOD:01376 + (2S,3S,4R)-3,4-dihydroxyisoleucine + + A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine. + + 11320328 + PubMed + + + AA0447 + RESID + + + + (2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid + RESID-systematic + + + (2S,3S,4R)-3,4-dihydroxyisoleucine + RESID-name + + + (3S,4R)-3,4-dihydroxyisoleucine + RESID-alternate + + + beta,gamma-dihydroxyisoleucine + RESID-alternate + + + MOD_RES (3S,4R)-3,4-dihydroxyisoleucine + UniProt-feature + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 11 N 1 O 3 + + + + MassAvg + 145.16 + + + + MassMono + 145.073893 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:01416 + PSI-MOD + + + MOD:01377 + (2S,3R,4S)-4-hydroxyisoleucine + + A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine. + + 363352 + PubMed + + + AA0448 + RESID + + + + (2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid + RESID-alternate + + + (2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid + RESID-systematic + + + (2S,3R,4S)-4-hydroxyisoleucine + RESID-name + + + (3R,4S)-4-hydroxyisoleucine + RESID-alternate + + + gamma-hydroxyisoleucine + RESID-alternate + + + MOD_RES (3R,4S)-4-hydroxyisoleucine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 11 N 1 O 2 + + + + MassAvg + 129.16 + + + + MassMono + 129.078979 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:01415 + PSI-MOD + + + MOD:01378 + (2S,3R,4R)-4,5-dihydroxyisoleucine + + A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine. + + 11805306 + PubMed + + + 18552824 + PubMed + + + 363352 + PubMed + + + AA0449 + RESID + + + + (2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid + RESID-systematic + + + (2S,3R,4R)-4,5-dihydroxyisoleucine + RESID-name + + + (3R,4R)-4,5-dihydroxyisoleucine + RESID-alternate + + + gamma,delta-dihydroxyisoleucine + RESID-alternate + + + MOD_RES (3R,4R)-4,5-dihydroxyisoleucine + UniProt-feature + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 11 N 1 O 3 + + + + MassAvg + 145.16 + + + + MassMono + 145.073893 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:01416 + PSI-MOD + + + MOD:01379 + 2'-methylsulfonyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan. + + 6893271 + PubMed + + + AA0450 + RESID + + + + 2'-methylsulfonyl-L-tryptophan + RESID-name + + + 2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole + RESID-systematic + + + MOD_RES 2'-methylsulfonyltryptophan + UniProt-feature + + + + DiffAvg + 78.09 + + + + DiffFormula + C 1 H 2 N 0 O 2 S 1 + + + + DiffMono + 77.977550 + + + + Formula + C 12 H 12 N 2 O 3 S 1 + + + + MassAvg + 264.30 + + + + MassMono + 264.056863 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00918 + PSI-MOD + + + MOD:01380 + 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide + + A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide. + + 11805306 + PubMed + + + 18552824 + PubMed + + + 363352 + PubMed + + + 4865716 + PubMed + + + AA0451 + RESID + + + Cross-link 2. + + 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide + RESID-name + + + 2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole + RESID-systematic + + + 6'-hydroxy-S-oxo-tryptathionine + RESID-alternate + + + CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys) + UniProt-feature + + + + DiffAvg + 29.98 + + + + DiffFormula + C 0 H -2 N 0 O 2 S 0 + + + + DiffMono + 29.974179 + + + + Formula + C 14 H 13 N 3 O 4 S 1 + + + + MassAvg + 319.33 + + + + MassMono + 319.062677 + + + + Origin + C, W + + + + Source + natural + + + + TermSpec + none + + MOD:00687 + MOD:00918 + PSI-MOD + + + MOD:01381 + O-palmitoleyl-L-serine + + A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine. + + 17141155 + PubMed + + + AA0455 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid + RESID-systematic + + + L-serine cis-9-hexadecenoate ester + RESID-alternate + + + LIPID O-palmitoleyl serine + UniProt-feature + + + mod186 + OMSSA-label + + + O-palmitoleyl-L-serine + RESID-name + + + O3-palmitoleyl-serine + RESID-alternate + + + + DiffAvg + 236.40 + + + + DiffFormula + C 16 H 28 N 0 O 1 + + + + DiffMono + 236.214016 + + + + Formula + C 19 H 33 N 1 O 3 + + + + MassAvg + 323.48 + + + + MassMono + 323.246044 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01768 + PSI-MOD + + + MOD:01382 + N,N,N-trimethyl-L-methionine + + A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine. + + 18611379 + PubMed + + + AA0456 + RESID + + + PSI-MOD-slim + + (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium + RESID-systematic + + + (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium + RESID-alternate + + + 2-trimethylammonio-4-(methylthio)butanoic acid + RESID-alternate + + + MOD_RES N,N,N-trimethylmethionine + UniProt-feature + + + N,N,N-trimethyl-L-methionine + RESID-name + + + N,N,N-trimethylmethionine cation + RESID-alternate + + + N,N,N-trimethylmethioninium + RESID-alternate + + + N2Me3+Met + PSI-MOD-label + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 S 0 + + + + DiffMono + 43.054227 + + + + FormalCharge + 1+ + + + + Formula + C 8 H 17 N 1 O 1 S 1 + + + + MassAvg + 175.29 + + + + MassMono + 175.102537 + + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:01463 + MOD:01698 + PSI-MOD + + + MOD:01383 + L-cystine S-oxide + + A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide. + + AA0457 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid + RESID-systematic + + + CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys) + UniProt-feature + + + cystine sulfoxide + RESID-alternate + + + L-cystine S-oxide + RESID-name + + + S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate + RESID-alternate + + + S-cysteinyl 3-(oxidosulfanyl)alanine + RESID-alternate + + + + DiffAvg + 13.98 + + + + DiffFormula + C 0 H -2 N 0 O 1 S 0 + + + + DiffMono + 13.979265 + + + + Formula + C 6 H 8 N 2 O 3 S 2 + + + + MassAvg + 220.26 + + + + MassMono + 219.997634 + + + + Origin + C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00689 + PSI-MOD + + + MOD:01384 + aminomalonic acid (Ser) + + A protein modification that effectively converts an L-serine residue to an aminomalonic acid. + + 1621954 + PubMed + + + 5415959 + PubMed + + + 6366787 + PubMed + + + 7457858 + PubMed + + + AA0458 + RESID + + + + 2-carboxyglycine + RESID-alternate + + + Ama + RESID-alternate + + + aminomalonic acid + RESID-name + + + aminopropanedioic acid + RESID-systematic + + + MOD_RES Aminomalonic acid (Ser) + UniProt-feature + + + + DiffAvg + 13.98 + + + + DiffFormula + C 0 H -2 N 0 O 1 S 0 + + + + DiffMono + 13.979265 + + + + Formula + C 3 H 3 N 1 O 3 + + + + MassAvg + 101.06 + + + + MassMono + 101.011293 + + + + Origin + S + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00916 + PSI-MOD + + + MOD:01385 + 3-hydroxy-L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine. + + 16795 + ChEBI + + + 10625477 + PubMed + + + 15651011 + PubMed + + + 16734421 + PubMed + + + 1880060 + PubMed + + + 7398618 + PubMed + + + 7844053 + PubMed + + + AA0462 + RESID + + + + (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid + RESID-systematic + + + 3-hydoxyphenylalanine + RESID-alternate + + + 3-hydroxy-L-phenylalanine + RESID-name + + + 3-phenyl-L-serine + RESID-alternate + + + 3HyPhe + PSI-MOD-label + + + beta-hydroxyphenylalanine + RESID-alternate + + + beta-phenylserine + RESID-alternate + + + hydroxylationf + OMSSA-label + + + L-threo-3-phenylserine + RESID-alternate + + + MOD_RES 3-hydroxyphenylalanine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 9 H 9 N 1 O 2 + + + + MassAvg + 163.18 + + + + MassMono + 163.063329 + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00677 + MOD:00914 + PSI-MOD + + + MOD:01386 + 3-hydroxy-L-valine + + A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine. + + 7328054 + PubMed + + + AA0463 + RESID + + + + (2S)-2-amino-3-hydroxy-3-methylbutanoic acid + RESID-systematic + + + 3-hydroxy-L-valine + RESID-name + + + 3-hydroxyvaline + RESID-alternate + + + 3HyVal + PSI-MOD-label + + + MOD_RES 3-hydroxyvaline + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 9 N 1 O 2 + + + + MassAvg + 115.13 + + + + MassMono + 115.063329 + + + + Origin + V + + + + Source + natural + + + + TermSpec + none + + MOD:00677 + MOD:00920 + PSI-MOD + + + MOD:01387 + O-methyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine. + + 7328054 + PubMed + + + AA0464 + RESID + + + + (2S,3R)-2-amino-3-methoxybutanoic acid + RESID-systematic + + + MOD_RES O-methylthreonine + UniProt-feature + + + O-methyl threonine + RESID-alternate + + + O-methyl-L-threonine + RESID-name + + + OMeThr + PSI-MOD-label + + + threonine methyl ether + RESID-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 5 H 9 N 1 O 2 + + + + MassAvg + 115.13 + + + + MassMono + 115.063329 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:01803 + PSI-MOD + + + MOD:01388 + 1-amino-2-propanol + + A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol. + + 15675 + ChEBI + + + 7328054 + PubMed + + + AA0465 + RESID + + + + (2R)-1-aminopropan-2-ol + RESID-systematic + + + 1-amino-2-hydroxypropane + RESID-alternate + + + 1-amino-2-propanol + RESID-name + + + 1-methyl-2-aminoethanol + RESID-alternate + + + 2-amino-1-methylethanol + RESID-alternate + + + 2-hydroxy-1-propylamine + RESID-alternate + + + 2-hydroxypropanamine + RESID-alternate + + + 2-hydroxypropylamine + RESID-alternate + + + alpha-aminoisopropyl alcohol + RESID-alternate + + + dCbxThr + PSI-MOD-label + + + decarboxylated threonine + RESID-alternate + + + isopropanolamine + RESID-alternate + + + MOD_RES Decarboxylated threonine + UniProt-feature + + + threamine + RESID-alternate + + + + DiffAvg + -44.01 + + + + DiffFormula + C -1 H 0 N 0 O -2 + + + + DiffMono + -43.989829 + + + + Formula + C 3 H 8 N 1 O 1 + + + + MassAvg + 74.10 + + + + MassMono + 74.060589 + + + + Origin + T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00917 + MOD:00960 + PSI-MOD + + + MOD:01389 + L-isoleucine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid. + + 11320328 + PubMed + + + AA0466 + RESID + + + Cross-link 2. + + 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys) + UniProt-feature + + + L-isoleucine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 9 H 12 N 2 O 1 S 1 + + + + MassAvg + 196.27 + + + + MassMono + 196.067034 + + + + Origin + C, I + + + + Source + natural + + + + TermSpec + none + + MOD:00910 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01390 + L-valine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid. + + 7328054 + PubMed + + + AA0467 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Val-Cys) + UniProt-feature + + + L-valine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 8 H 10 N 2 O 1 S 1 + + + + MassAvg + 182.24 + + + + MassMono + 182.051384 + + + + Origin + C, V + + + + Source + natural + + + + TermSpec + none + + MOD:00920 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01391 + L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid. + + 10625477 + PubMed + + + 1880060 + PubMed + + + 7844053 + PubMed + + + AA0468 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys) + UniProt-feature + + + L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + 24.02 + + + + DiffFormula + C 2 H 0 N 0 O 0 S 0 + + + + DiffMono + 24.000000 + + + + Formula + C 10 H 14 N 2 O 2 S 1 + + + + MassAvg + 226.29 + + + + MassMono + 226.077599 + + + + Origin + C, V + + + + Source + natural + + + + TermSpec + none + + MOD:00920 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01392 + L-asparagine 5-methylthiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid. + + 10625477 + PubMed + + + 1880060 + PubMed + + + 7844053 + PubMed + + + AA0469 + RESID + + + Cross-link 2. + + 2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + 2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys) + UniProt-feature + + + L-asparagine 5-methylthiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -6.00 + + + + DiffFormula + C 1 H -2 N 0 O -1 S 0 + + + + DiffMono + -6.010565 + + + + Formula + C 8 H 9 N 3 O 2 S 1 + + + + MassAvg + 211.24 + + + + MassMono + 211.041548 + + + + Origin + C, N + + + + Source + natural + + + + TermSpec + none + + MOD:00903 + MOD:01420 + MOD:01888 + + derives_from + MOD:006560 + + PSI-MOD + + + MOD:01393 + L-cysteine pyridine-2,5-dicarboxylic acid + + A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid. + + 10625477 + PubMed + + + 1880060 + PubMed + + + 7844053 + PubMed + + + AA0470 + RESID + + + Cross-link 3. + + 6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid + RESID-systematic + + + L-cysteine pyridine-2,5-dicarboxylic acid + RESID-name + + + + DiffAvg + -70.07 + + + + DiffFormula + C 0 H -8 N -1 O -3 S 0 + + + + DiffMono + -70.050418 + + + + Formula + C 9 H 7 N 2 O 2 S 1 + + + + MassAvg + 207.23 + + + + MassMono + 207.022823 + + + + Origin + C, S, S + + + + Source + natural + + + + TermSpec + none + + MOD:01425 + PSI-MOD + + + MOD:01394 + L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid + + A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid. + + 11320328 + PubMed + + + AA0471 + RESID + + + Cross-link 3. + + (5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid + RESID-systematic + + + L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid + RESID-name + + + L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid + RESID-alternate + + + + DiffAvg + -53.04 + + + + DiffFormula + C 0 H -5 N 0 O -3 S 0 + + + + DiffMono + -53.023869 + + + + Formula + C 9 H 11 N 3 O 2 S 1 + + + + MassAvg + 225.27 + + + + MassMono + 225.057198 + + + + Origin + C, S, S + + + + Source + natural + + + + TermSpec + N-term + + MOD:01425 + PSI-MOD + + + MOD:01395 + 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol + + A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol. + + 11320328 + PubMed + + + AA0472 + RESID + + + Cross-link 2. + + (7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline + RESID-systematic + + + 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol + RESID-name + + + BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links) + UniProt-feature + + + + DiffAvg + 215.21 + + + + DiffFormula + C 12 H 9 N 1 O 3 + + + + DiffMono + 215.058243 + + + + Formula + C 22 H 28 N 3 O 6 + + + + MassAvg + 430.48 + + + + MassMono + 430.197811 + + + + Origin + I, T + + + + Source + natural + + + + TermSpec + N-term + + MOD:00910 + MOD:00917 + MOD:01424 + PSI-MOD + + + MOD:01396 + 5-hydroxy-3-methyl-L-proline (Pro) + + A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline. + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0473 + RESID + + + This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG]. + + (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid + RESID-systematic + + + 5-hydroxy-3-methyl-L-proline + RESID-name + + + 5-hydroxy-3-methylproline + RESID-alternate + + + 5Hy3MePro + PSI-MOD-label + + + beta-methyl-delta-hydroxyproline + RESID-alternate + + + MOD_RES 5-hydroxy-3-methylproline (Ile) + UniProt-feature + + + + DiffAvg + 30.03 + + + + DiffFormula + C 1 H 2 N 0 O 1 + + + + DiffMono + 30.010565 + + + + Formula + C 6 H 9 N 1 O 2 + + + + MassAvg + 127.14 + + + + MassMono + 127.063329 + + + + Origin + P + + + + Source + artifactual + + + + TermSpec + none + + MOD:00915 + + has_functional_parent + MOD:010240 + + + has_functional_parent + MOD:014170 + + PSI-MOD + + + MOD:01397 + L-serine 5-methyloxazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid. + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0474 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr) + UniProt-feature + + + L-serine 5-methyloxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 8 N 2 O 3 + + + + MassAvg + 168.15 + + + + MassMono + 168.053492 + + + + Origin + S, T + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01422 + MOD:01888 + PSI-MOD + + + MOD:01398 + N6-propanoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine. + + 17267393 + PubMed + + + 17684016 + PubMed + + + 20715035 + PubMed + + + AA0475 + RESID + + + 58#K + UniMod + + + The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. + PSI-MOD-slim + + (2S)-2-amino-6-(propanoylamino)hexanoic acid + RESID-systematic + + + 2-amino-6-propionylaminocaproic acid + RESID-alternate + + + epsilon-propanoyl-L-lysine + RESID-alternate + + + epsilon-propionyl-L-lysine + RESID-alternate + + + N(zeta)-propanoyllysine + RESID-alternate + + + N6-(1-oxopropyl)-L-lysine + RESID-alternate + + + N6-propanoyl-L-lysine + RESID-name + + + N6-propionyllysine + RESID-alternate + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 N 0 O 1 + + + + DiffMono + 56.026215 + + + + Formula + C 9 H 16 N 2 O 2 + + + + MassAvg + 184.24 + + + + MassMono + 184.121178 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01155 + MOD:01875 + MOD:01894 + PSI-MOD + + + MOD:01399 + N6-(ADP-ribosyl)-L-lysine + + A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine. + + 18436469 + PubMed + + + AA0476 + RESID + + + + (S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid + RESID-systematic + + + 2-amino-6-(ADP-ribosyl)amino-hexanoic acid + RESID-alternate + + + epsilon-ADP-ribosyllysine + RESID-alternate + + + MOD_RES N6-(ADP-ribosyl)lysine + UniProt-feature + + + N(zeta)-ADP-ribosyllysine + RESID-alternate + + + N6-(ADP-ribosyl)-L-lysine + RESID-name + + + N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine + RESID-alternate + + + N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 21 H 33 N 7 O 14 P 2 + + + + MassAvg + 669.48 + + + + MassMono + 669.156072 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00752 + MOD:00912 + PSI-MOD + + + MOD:01400 + L-lysyl-poly(ADP-ribose) + + A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose). + + 6772638 + PubMed + + + AA0477 + RESID + + + + L-lysyl-poly(ADP-ribose) + RESID-name + + + MOD_RES Lysyl poly(ADP-ribose) + UniProt-feature + + + poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate + RESID-systematic + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 21 H 34 N 7 O 15 P 2 + + + + MassAvg + 686.48 + + + + MassMono + 686.158812 + + + + Origin + K + + + + Source + natural + + + + TermSpec + C-term + + MOD:00752 + MOD:00912 + PSI-MOD + + + MOD:01401 + (2S,3S)-3-hydroxyasparagine + + A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine. + + 50789 + ChEBI + + + 11823643 + PubMed + + + 12042299 + PubMed + + + 12215170 + PubMed + + + 17573339 + PubMed + + + AA0478 + RESID + + + PSI-MOD-slim + + (2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid + RESID-alternate + + + (2S,3S)-2-amino-3-hydroxy-4-butanediamic acid + RESID-systematic + + + (2S,3S)-3-hydroxyasparagine + RESID-name + + + (3S)3HyAsn + PSI-MOD-label + + + L-threo-beta-hydroxyasparagine + RESID-alternate + + + MOD_RES (3S)-3-hydroxyasparagine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 4 H 6 N 2 O 3 + + + + MassAvg + 130.10 + + + + MassMono + 130.037842 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:01688 + PSI-MOD + + + MOD:01402 + (2S,3R,4R)-3,4-dihydroxyproline + + A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline. + + 6893271 + PubMed + + + AA0479 + RESID + + + + (2S,3R,4R)-3,4-dihydroxyproline + RESID-name + + + (2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid + RESID-systematic + + + 2,3-trans-3,4-trans-3,4-dihydroxy-L-proline + RESID-alternate + + + 2-alpha-3-beta-4-alpha-3,4-dihydroxyproline + RESID-alternate + + + MOD_RES (3R,4R)-3,4-dihydroxyproline + UniProt-feature + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00866 + PSI-MOD + + + MOD:01403 + (2S)-4,5,5'-trihydroxyleucine + + A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine. + + 6893271 + PubMed + + + AA0480 + RESID + + + + (2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid + RESID-systematic + + + (2S)-4,5,5'-trihydroxyleucine + RESID-name + + + 4,5,5'-trihydroxyleucine + RESID-alternate + + + gamma,delta,delta'-trihydroxyleucine + RESID-alternate + + + MOD_RES 4,5,4'-trihydroxyleucine + UniProt-feature + + + + DiffAvg + 48.00 + + + + DiffFormula + C 0 H 0 N 0 O 3 + + + + DiffMono + 47.984744 + + + + Formula + C 6 H 11 N 1 O 4 + + + + MassAvg + 161.16 + + + + MassMono + 161.068808 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:01413 + PSI-MOD + + + MOD:01404 + L-asparagine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid. + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0481 + RESID + + + Cross-link 2. + + 2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys) + UniProt-feature + + + L-asparagine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 7 N 3 O 2 S 1 + + + + MassAvg + 197.21 + + + + MassMono + 197.025897 + + + + Origin + C, N + + + + Source + natural + + + + TermSpec + none + + MOD:00903 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01405 + L-proline thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid. + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0482 + RESID + + + Cross-link 2. + + 2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys) + UniProt-feature + + + L-proline thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 8 H 8 N 2 O 1 S 1 + + + + MassAvg + 180.22 + + + + MassMono + 180.035734 + + + + Origin + C, P + + + + Source + natural + + + + TermSpec + none + + MOD:00915 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01406 + L-threonine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid. + + 11320328 + PubMed + + + AA0483 + RESID + + + Cross-link 2. + + 2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys) + UniProt-feature + + + L-threonine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 8 N 2 O 2 S 1 + + + + MassAvg + 184.21 + + + + MassMono + 184.030649 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01407 + L-phenylalanine thiazoline-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid. + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0484 + RESID + + + Cross-link 2. + + (4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys) + UniProt-feature + + + L-phenylalanine thiazoline-4-carboxylic acid + RESID-name + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 12 H 12 N 2 O 1 S 1 + + + + MassAvg + 232.30 + + + + MassMono + 232.067034 + + + + Origin + C, F + + + + Source + natural + + + + TermSpec + none + + MOD:00914 + MOD:01420 + PSI-MOD + + + MOD:01408 + L-threonine thiazoline-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid. + + 11320328 + PubMed + + + AA0485 + RESID + + + Cross-link 2. + + (4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys) + UniProt-feature + + + L-threonine (4S)-thiazoline-4-carboxylic acid + RESID-name + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 10 N 2 O 2 S 1 + + + + MassAvg + 186.23 + + + + MassMono + 186.046299 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01420 + PSI-MOD + + + MOD:01409 + trihydroxylated residue + + A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups. + + 18688235 + PubMed + + + + Hy3Res + PSI-MOD-label + + + + DiffAvg + 48.00 + + + + DiffFormula + C 0 H 0 N 0 O 3 + + + + DiffMono + 47.984744 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00677 + PSI-MOD + + + MOD:01410 + hydroxylated leucine + + A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine. + + 18688235 + PubMed + + + + HyLeu + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + L + + + + Source + none + + + + TermSpec + none + + MOD:00677 + MOD:00911 + PSI-MOD + + + MOD:01411 + monohydroxylated leucine + + A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine. + + 18688235 + PubMed + + + + Hy1Leu + PSI-MOD-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 11 N 1 O 2 + + + + MassAvg + 129.16 + + + + MassMono + 129.078979 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:01410 + PSI-MOD + + + MOD:01412 + dihydroxylated leucine + + A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine. + + 18688235 + PubMed + + + + Hy2Leu + PSI-MOD-label + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 11 N 1 O 3 + + + + MassAvg + 145.16 + + + + MassMono + 145.073893 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:00428 + MOD:01410 + PSI-MOD + + + MOD:01413 + trihydroxylated leucine + + A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine. + + 18688235 + PubMed + + + + Hy3Leu + PSI-MOD-label + + + + DiffAvg + 48.00 + + + + DiffFormula + C 0 H 0 N 0 O 3 + + + + DiffMono + 47.984744 + + + + Formula + C 6 H 11 N 1 O 4 + + + + MassAvg + 161.16 + + + + MassMono + 161.068808 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:01409 + MOD:01410 + PSI-MOD + + + MOD:01414 + hydroxylated isoleucine + + A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine. + + 18688235 + PubMed + + + + HyIle + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + I + + + + Source + none + + + + TermSpec + none + + MOD:00677 + MOD:00910 + PSI-MOD + + + MOD:01415 + monohydroxylated isoleucine + + A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine. + + 18688235 + PubMed + + + + Hy1Ile + PSI-MOD-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 11 N 1 O 2 + + + + MassAvg + 129.16 + + + + MassMono + 129.078979 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:01414 + PSI-MOD + + + MOD:01416 + dihydroxylated isoleucine + + A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine. + + 18688235 + PubMed + + + + Hy2Ile + PSI-MOD-label + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 11 N 1 O 3 + + + + MassAvg + 145.16 + + + + MassMono + 145.073893 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00428 + MOD:01414 + PSI-MOD + + + MOD:01417 + monomethylated proline + + A protein modification that effectively converts an L-proline residue to a monomethylated proline. + + 18688235 + PubMed + + + PSI-MOD-slim + + Me1Pro + PSI-MOD-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 6 H 10 N 1 O 1 + + + + MassAvg + 112.15 + + + + MassMono + 112.076239 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00599 + MOD:00712 + PSI-MOD + + + MOD:01418 + methylated threonine + + A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine. + + 18688235 + PubMed + + + + MeThr + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00427 + MOD:00917 + PSI-MOD + + + MOD:01419 + oxazole/oxazoline ring crosslinked residues + + A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. + + 18688235 + PubMed + + + MOD:00690 + PSI-MOD + + + MOD:01420 + thiazole/thiazoline ring croslinked residues + + A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring. + + 18688235 + PubMed + + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00687 + MOD:00690 + PSI-MOD + + + MOD:01421 + oxazole/oxazoline ring crosslinked residues (Ser) + + A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring. + + 18688235 + PubMed + + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01419 + PSI-MOD + + + MOD:01422 + oxazole/oxazoline ring crosslinked residues (Thr) + + A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring. + + 18688235 + PubMed + + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01419 + PSI-MOD + + + MOD:01423 + palmitoleylated residue + + A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group. + + 431 + UniMod + + + PSI-MOD-slim + + + DiffAvg + 236.40 + + + + DiffFormula + C 16 H 28 N 0 O 1 + + + + DiffMono + 236.214016 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:01424 + quinaldate modified residue + + A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group. + + 18688235 + PubMed + + + MOD:01156 + PSI-MOD + + + MOD:01425 + pyridinyl ring crosslinked residues + + A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid. + + 18688235 + PubMed + + + Cross-link 3. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C, S, S + + + + Source + natural + + + + TermSpec + none + + MOD:00033 + MOD:00905 + MOD:00916 + PSI-MOD + + + MOD:01426 + isotope tagged reagent derivatized residue + + A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00848 + PSI-MOD + + + MOD:01427 + 2-aminobutanoic acid (Abu) + + OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819. + + 18688235 + PubMed + + + + Abu + DeltaMass-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 4 H 7 N 1 O 1 + + + + MassAvg + 85.11 + + + + MassMono + 85.052764 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01428 + (13)C isotope tagged reagent + + A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01426 + PSI-MOD + + + MOD:01429 + (15)N isotope tagged reagent + + A protein modification that forms an adduct with a (15)N labeled compound used as a reagent. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01426 + PSI-MOD + + + MOD:01430 + (18)O isotope tagged reagent + + A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01426 + PSI-MOD + + + MOD:01431 + (2)H deuterium tagged reagent + + A protein modification that forms an adduct with a (2)H labeled compound used as a reagent. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01426 + PSI-MOD + + + MOD:01432 + (2S,4S)-4,5-dihydroxyleucine + + A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine. + + 3718926 + PubMed + + + AA0446 + RESID + + + + (2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid + RESID-systematic + + + (2S,4S)-4,5-dihydroxyleucine + RESID-name + + + (4S)-4,5-dihydroxyleucine + RESID-alternate + + + gamma,delta-dihydroxyleucine + RESID-alternate + + + + DiffAvg + 32.00 + + + + DiffFormula + C 0 H 0 N 0 O 2 + + + + DiffMono + 31.989829 + + + + Formula + C 6 H 11 N 1 O 3 + + + + MassAvg + 145.16 + + + + MassMono + 145.073893 + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:01412 + PSI-MOD + + + MOD:01433 + 1-amino-2-propanone + + A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone. + + 17906 + ChEBI + + + 12715872 + PubMed + + + 19196969 + PubMed + + + AA0486 + RESID + + + + 1-amino-2-propanone + RESID-name + + + 1-aminopropan-2-one + RESID-alternate + + + 1-aminopropanone + RESID-systematic + + + aminoacetone + RESID-alternate + + + MOD_RES 1-amino-2-propanone + UniProt-feature + + + + DiffAvg + -46.03 + + + + DiffFormula + C -1 H -2 N 0 O -2 + + + + DiffMono + -46.005479 + + + + Formula + C 3 H 6 N 1 O 1 + + + + MassAvg + 72.09 + + + + MassMono + 72.044939 + + + + Origin + T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00683 + MOD:00917 + MOD:00960 + PSI-MOD + + + MOD:01434 + 4-hydroxy-L-glutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid. + + 893891 + PubMed + + + AA0487 + RESID + + + + (2S,4Xi)-2-amino-4-hydroxypentanedioic acid + RESID-systematic + + + 4-hydroxy-L-glutamic acid + RESID-name + + + gamma-hydroxy glutaminic acid + RESID-alternate + + + MOD_RES 4-hydroxyglutamate + UniProt-feature + + + threo-4-hydroxy-L-glutamic acid + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 7 N 1 O 4 + + + + MassAvg + 145.11 + + + + MassMono + 145.037508 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00906 + PSI-MOD + + + MOD:01435 + 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole + + A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole. + + 893891 + PubMed + + + AA0488 + RESID + + + Cross-link 2. + + 2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole + RESID-systematic + + + 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole + RESID-name + + + 2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole + RESID-alternate + + + BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links) + UniProt-feature + + + + DiffAvg + 169.18 + + + + DiffFormula + C 11 H 7 N 1 O 1 S 0 + + + + DiffMono + 169.052764 + + + + Formula + C 19 H 19 N 3 O 5 S 1 + + + + MassAvg + 401.44 + + + + MassMono + 401.104542 + + + + Origin + C, E + + + + Source + natural + + + + TermSpec + none + + MOD:00672 + MOD:00905 + MOD:00906 + PSI-MOD + + + MOD:01436 + cyclo[(prolylserin)-O-yl] cysteinate (Cys) + + A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate. + + 7961166 + PubMed + + + AA0489#CYS + RESID + + + + (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate + RESID-alternate + + + [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate + RESID-systematic + + + cyclo[(prolylserin)-O-yl] cysteinate + RESID-name + + + MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate + UniProt-feature + + + + DiffAvg + 166.18 + + + + DiffFormula + C 8 H 10 N 2 O 2 S 0 + + + + DiffMono + 166.074228 + + + + Formula + C 11 H 16 N 3 O 4 S 1 + + + + MassAvg + 286.33 + + + + MassMono + 286.086152 + + + + Origin + C + + + + Source + natural + + + + TermSpec + C-term + + MOD:01629 + PSI-MOD + + + MOD:01437 + cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link) + + A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate. + + 7961166 + PubMed + + + AA0489#TRI + RESID + + + Cross-link 3. + + (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate + RESID-alternate + + + [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate + RESID-systematic + + + cyclo[(prolylserin)-O-yl] cysteinate + RESID-name + + + MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate + UniProt-feature + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 11 H 16 N 3 O 4 S 1 + + + + MassAvg + 286.33 + + + + MassMono + 286.086152 + + + + Origin + C, P, S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00915 + MOD:00916 + MOD:01629 + PSI-MOD + + + MOD:01438 + S-[2-(pyridin-2-yl)ethyl]-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine. + + 18369855 + PubMed + + + 18688235 + PubMed + + + From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286 + + 2-PEC + PSI-MOD-alternate + + + 2-vinylpyridine derivatized cysteine residue + PSI-MOD-alternate + + + Pyridylethyl + PSI-MS-label + + + Pyridylethyl Cystenyl + DeltaMass-label + + + S-(pyridin-2-ylethyl)-L-cysteine + PSI-MOD-alternate + + + S-pyridylethylation + UniMod-description + + + + DiffAvg + 105.14 + + + + DiffFormula + C 7 H 7 N 1 + + + + DiffMono + 105.057849 + + + + Formula + C 10 H 12 N 2 O 1 S 1 + + + + MassAvg + 208.28 + + + + MassMono + 208.067034 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00424 + PSI-MOD + + + MOD:01439 + S-[2-(pyridin-4-yl)ethyl]-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine. + + 18688235 + PubMed + + + 6528972 + PubMed + + + + 4-PEC + PSI-MOD-alternate + + + Pyridylethyl + PSI-MS-label + + + Pyridylethyl Cystenyl + DeltaMass-label + + + S-(pyridin-4-ylethyl)-L-cysteine + PSI-MOD-alternate + + + S-pyridylethylation + UniMod-description + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00424 + PSI-MOD + + + MOD:01440 + glutamyl semialdehyde + + A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde. + + 18688235 + PubMed + + + + (S)-2-amino-5-oxopentanoic acid + PSI-MOD-alternate + + + L-glutamic gamma-semialdehyde + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00859 + PSI-MOD + + + MOD:01441 + natural, standard, encoded residue + + A protein modification that inserts or replaces a residue with a natural, standard, encoded residue. + + 18688235 + PubMed + + + 6692818 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00009 + PSI-MOD + + + MOD:01442 + 3-(O4'-L-tyrosyl)-L-valine + + A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine. + + 19321420 + PubMed + + + AA0490 + RESID + + + Cross-link 2. + + (2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid + RESID-systematic + + + 3-(O4'-L-tyrosyl)-L-valine + RESID-name + + + CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 14 H 16 N 2 O 3 + + + + MassAvg + 260.29 + + + + MassMono + 260.116092 + + + + Origin + V, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00919 + MOD:00920 + PSI-MOD + + + MOD:01443 + tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide + + A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide. + + 19321420 + PubMed + + + AA0491 + RESID + + + Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG]. + + + DiffAvg + 350.12 + + + + DiffFormula + C 14 Fe 1 H 23 Mn 1 N 0 O 3 + + + + DiffMono + 350.038251 + + + + FormalCharge + 1- + + + + Formula + C 46 Fe 1 H 65 Mn 1 N 10 O 17 + + + + MassAvg + 1140.86 + + + + MassMono + 1140.326447 + + + + Origin + E, E, E, E, H, H + + + + Source + natural + + + + TermSpec + none + + MOD:00438 + MOD:00738 + MOD:00740 + MOD:00906 + MOD:00909 + PSI-MOD + + + MOD:01444 + L-3,3-dihydroxyoalanine (Cys) + + A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine. + + 11435113 + PubMed + + + 17558559 + PubMed + + + AA0492#CYS + RESID + + + + (S)-2-amino-3,3-dihydroxypropanoic acid + RESID-systematic + + + 2-(dihydroxymethyl)glycine + RESID-alternate + + + 3,3-dihydroxy-L-alanine + RESID-name + + + 3,3-dihydroxyalanine + RESID-alternate + + + 3-hydroxy-L-serine + RESID-alternate + + + 3-oxoalanine hydrate + RESID-alternate + + + C(alpha)-formylglycine hydrate + RESID-misnomer + + + + DiffAvg + -0.06 + + + + DiffFormula + C 0 H 0 N 0 O 2 S -1 + + + + DiffMono + 0.017758 + + + + Formula + C 3 H 5 N 1 O 3 + + + + MassAvg + 103.08 + + + + MassMono + 103.026943 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01448 + PSI-MOD + + + MOD:01445 + L-3,3-dihydroxyoalanine (Ser) + + A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine. + + 11435113 + PubMed + + + 17558559 + PubMed + + + AA0492#SER + RESID + + + + (S)-2-amino-3,3-dihydroxypropanoic acid + RESID-systematic + + + 2-(dihydroxymethyl)glycine + RESID-alternate + + + 3,3-dihydroxy-L-alanine + RESID-name + + + 3,3-dihydroxyalanine + RESID-alternate + + + 3-hydroxy-L-serine + RESID-alternate + + + 3-oxoalanine hydrate + RESID-alternate + + + C(alpha)-formylglycine hydrate + RESID-misnomer + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 3 H 5 N 1 O 3 + + + + MassAvg + 103.08 + + + + MassMono + 103.026943 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01448 + PSI-MOD + + + MOD:01446 + N-(dihydroxymethyl)-L-methionine (fMet) + + A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine. + + 12595263 + PubMed + + + 9159480 + PubMed + + + AA0493 + RESID + + + + (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + N-(dihydroxymethyl)-L-methionine + RESID-name + + + N-formyl-L-methionine hydrate + RESID-alternate + + + N-orthoformylmethionine + RESID-alternate + + + + DiffAvg + 18.02 + + + + DiffFormula + C 0 H 2 N 0 O 1 S 0 + + + + DiffMono + 18.010565 + + + + Formula + C 6 H 12 N 1 O 3 S 1 + + + + MassAvg + 178.23 + + + + MassMono + 178.053789 + + + + Origin + MOD:00030 + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:01450 + + derives_from + MOD:000300 + + PSI-MOD + + + MOD:01447 + N-(dihydroxymethyl)-L-methionine (Met) + + A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process). + + 12595263 + PubMed + + + 9159480 + PubMed + + + AA0493 + RESID + + + This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446. + + (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + N-(dihydroxymethyl)-L-methionine + RESID-name + + + N-formyl-L-methionine hydrate + RESID-alternate + + + N-orthoformylmethionine + RESID-alternate + + + + DiffAvg + 46.03 + + + + DiffFormula + C 1 H 2 N 0 O 2 S 0 + + + + DiffMono + 46.005479 + + + + Formula + C 6 H 12 N 1 O 3 S 1 + + + + MassAvg + 178.23 + + + + MassMono + 178.053789 + + + + Origin + M + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00913 + PSI-MOD + + + MOD:01448 + L-3,3-dihydroxyoalanine + + A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine. + + 11435113 + PubMed + + + 17558559 + PubMed + + + AA0492 + RESID + + + + (S)-2-amino-3,3-dihydroxypropanoic acid + RESID-systematic + + + 2-(dihydroxymethyl)glycine + RESID-alternate + + + 3,3-dihydroxy-L-alanine + RESID-name + + + 3,3-dihydroxyalanine + RESID-alternate + + + 3-hydroxy-L-serine + RESID-alternate + + + 3-oxoalanine hydrate + RESID-alternate + + + C(alpha)-formylglycine hydrate + RESID-misnomer + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 3 H 5 N 1 O 3 + + + + MassAvg + 103.08 + + + + MassMono + 103.026943 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + PSI-MOD + + + MOD:01449 + L-3,3-dihydroxyoalanine (Oxoalanine) + + A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine. + + 11435113 + PubMed + + + 17558559 + PubMed + + + 18688235 + PubMed + + + + + DiffAvg + 18.02 + + + + DiffFormula + C 0 H 2 N 0 O 1 + + + + DiffMono + 18.010565 + + + + Formula + C 3 H 5 N 1 O 3 + + + + MassAvg + 103.08 + + + + MassMono + 103.026943 + + + + Origin + MOD:01169 + + + + Source + natural + + + + TermSpec + none + + MOD:01448 + + derives_from + MOD:011690 + + PSI-MOD + + + MOD:01450 + modified N-formyl-L-methionine residue + + A protein modification that modifies an N-formyl-L-methionine residue. + + 18688235 + PubMed + + + + + Origin + MOD:00030 + + + + TermSpec + N-term + + MOD:01157 + + derives_from + MOD:000300 + + PSI-MOD + + + MOD:01451 + O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine + + A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. + + 17042494 + PubMed + + + 18688235 + PubMed + + + Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin. + PSI-MOD-slim + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 3 H 6 N 1 O 5 P 1 + + + + MassAvg + 167.06 + + + + MassMono + 166.998359 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00046 + MOD:00431 + + derives_from + MOD:001590 + + PSI-MOD + + + MOD:01452 + O-phosphopantetheine-L-serine with neutral loss of pantetheine + + Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. + + 17042494 + PubMed + + + 18688235 + PubMed + + + Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin. + PSI-MOD-slim + + + DiffAvg + -260.35 + + + + DiffFormula + C -11 H -20 N -2 O -3 P 0 S -1 + + + + DiffMono + -260.119464 + + + + Formula + C 3 H 6 N 1 O 5 P 1 + + + + MassAvg + 167.06 + + + + MassMono + 166.998359 + + + + Origin + MOD:00159 + + + + Source + artifact + + + + TermSpec + none + + MOD:00046 + MOD:00431 + + derives_from + MOD:001590 + + PSI-MOD + + + MOD:01453 + L-glutamic acid 5-methyl ester + + A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester. + + AA0072 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-5-methoxy-5-oxopentanoic acid + RESID-systematic + + + (5)-methyl L-hydrogen glutamate + RESID-alternate + + + 2-aminopentanedioic acid 5-methyl ester + RESID-alternate + + + 5-methyl esterified L-glutamic acid + PSI-MOD-alternate + + + 5-methyl L-2-aminoglutarate + RESID-alternate + + + 5-methyl L-glutamate + RESID-alternate + + + glutamic acid 5-methyl ester + RESID-alternate + + + glutamic acid gamma-methyl ester + RESID-alternate + + + L-glutamic acid 5-methyl ester + RESID-name + + + O-methyl Glutamyl + DeltaMass-label + + + O5MeGlu + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 9 N 1 O 3 + + + + MassAvg + 143.14 + + + + MassMono + 143.058243 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00393 + MOD:00599 + MOD:00713 + MOD:00859 + PSI-MOD + + + MOD:01454 + N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium + + A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium. + + 10833024 + PubMed + + + 11847126 + PubMed + + + 9030608 + PubMed + + + AA0494 + RESID + + + This linkage is not a Schiff-base [JSG]. + + (1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium + RESID-systematic + + + DNA glycosylase proline Schiff base intermediate + RESID-misnomer + + + N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium + RESID-name + + + + DiffAvg + 179.09 + + + + DiffFormula + C 5 H 8 N 0 O 5 P 1 + + + + DiffMono + 179.010386 + + + + FormalCharge + 1+ + + + + Formula + C 10 H 16 N 1 O 6 P 1 + + + + MassAvg + 277.21 + + + + MassMono + 277.070975 + + + + Origin + P + + + + Source + natural + + + + TermSpec + N-term + + MOD:00750 + MOD:00915 + PSI-MOD + + + MOD:01455 + O-phosphorylated residue + + A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate'). + + 18688235 + PubMed + + + PSI-MOD-slim + + OPhosRes + PSI-MOD-label + + + + DiffAvg + 79.98 + + + + DiffFormula + H 1 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00696 + PSI-MOD + + + MOD:01456 + N-phosphorylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate'). + + 18688235 + PubMed + + + PSI-MOD-slim + + OPhosRes + PSI-MOD-label + + + + DiffAvg + 79.98 + + + + DiffFormula + H 1 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00696 + PSI-MOD + + + MOD:01457 + L-cysteine (Ser) + + A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process). + + 1849824 + PubMed + + + 18688235 + PubMed + + + + Cys(Ser) + PSI-MOD-label + + + + DiffAvg + -16.06 + + + + DiffFormula + C 0 H 0 N 0 O 1 S -1 + + + + DiffMono + -15.977156 + + + + Formula + C 3 H 5 N 1 O 1 S 1 + + + + MassAvg + 103.14 + + + + MassMono + 103.009185 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00014 + MOD:00749 + MOD:00916 + PSI-MOD + + + MOD:01458 + alpha-amino acetylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group. + + 1#N-term + UniMod + + + PSI-MOD-slim + + N2AcRes + PSI-MOD-label + + + ntermacetyl + OMSSA-label + + + + DiffAvg + 42.04 + + + + DiffFormula + C 2 H 2 N 0 O 1 + + + + DiffMono + 42.010565 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00408 + MOD:01696 + PSI-MOD + + + MOD:01459 + 4x(2)H labeled alpha-dimethylamino N-terminal residue + + A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue. + + 14670044 + PubMed + + + 199#N-term + UniMod + + + Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. + PSI-MOD-slim + + DiMethyl-CHD2 + UniMod-description + + + Dimethyl:2H(4) + PSI-MS-label + + + mod190 + OMSSA-label + + + + DiffAvg + 32.06 + + + + DiffFormula + C 2 (2)H 4 + + + + DiffMono + 32.056407 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00552 + PSI-MOD + + + MOD:01460 + alpha-amino methylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + N2MeRes + PSI-MOD-label + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00602 + PSI-MOD + + + MOD:01461 + N-methylated alanine + + A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + A + + + + Source + natural + + + + TermSpec + none + + MOD:00665 + MOD:01460 + PSI-MOD + + + MOD:01462 + N-methylated proline + + A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + P + + + + Source + natural + + + + TermSpec + N-term + + MOD:00712 + MOD:01460 + PSI-MOD + + + MOD:01463 + N-methylated methionine + + A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:00716 + MOD:01460 + PSI-MOD + + + MOD:01464 + protonated L-methionine (L-methioninium) residue + + A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine). + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 S 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 11 N 1 O 1 S 1 + + + + MassAvg + 133.21 + + + + MassMono + 133.055586 + + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:00913 + MOD:01700 + PSI-MOD + + + MOD:01465 + N,N,N-trimethyl-L-methionine (from L-methioninium) + + A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine. + + 18688235 + PubMed + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation. + PSI-MOD-slim + + N2Me3Met + PSI-MOD-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 S 0 + + + + DiffMono + 42.046402 + + + + FormalCharge + 1+ + + + + Formula + C 8 H 17 N 1 O 1 S 1 + + + + MassAvg + 175.29 + + + + MassMono + 175.102537 + + + + Origin + MOD:001464 + + + + Source + natural + + + + TermSpec + N-term + + MOD:01687 + + derives_from + MOD:014640 + + PSI-MOD + + + MOD:01466 + menadione quinone derivative - site C + + modification from UniMod Chemical derivative + + 15939799 + PubMed + + + 302#K + UniMod + + + + Menadione + UniMod-interim + + + Menadione quinone derivative + UniMod-description + + + + DiffAvg + 170.17 + + + + DiffFormula + C 11 H 6 O 2 + + + + DiffMono + 170.036779 + + + + Formula + C 14 H 11 N 1 O 3 S 1 + + + + MassAvg + 273.31 + + + + MassMono + 273.045964 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00621 + MOD:00905 + PSI-MOD + + + MOD:01467 + menadione quinone derivative - site K + + modification from UniMod Chemical derivative + + 15939799 + PubMed + + + 302#K + UniMod + + + + Menadione + UniMod-interim + + + Menadione quinone derivative + UniMod-description + + + + DiffAvg + 170.17 + + + + DiffFormula + C 11 H 6 O 2 + + + + DiffMono + 170.036779 + + + + Formula + C 17 H 18 N 2 O 3 + + + + MassAvg + 298.34 + + + + MassMono + 298.131742 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00621 + MOD:00912 + PSI-MOD + + + MOD:01468 + L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys) + + A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). + + 14235557 + PubMed + + + 2211698 + PubMed + + + 8052647 + PubMed + + + 9036855 + PubMed + + + AA0248#CYS + RESID + + + 415 + UniMod + + + This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253. + + 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide + RESID-alternate + + + bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum + RESID-systematic + + + formate dehydrogenase selenocysteine molybdenum cofactor + RESID-alternate + + + L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) + UniMod-description + + + L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) + RESID-name + + + molybdopterin-se + UniMod-interim + + + MolybdopterinGD+Delta:S(-1)Se(1) + PSI-MS-label + + + + DiffAvg + 1618.93 + + + + DiffFormula + C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1 + + + + DiffMono + 1620.930226 + + + + Formula + C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1 + + + + MassAvg + 1722.07 + + + + MassMono + 1723.939410 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00744 + MOD:00905 + PSI-MOD + + + MOD:01469 + L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys) + + A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). + + 11372198 + PubMed + + + 12220497 + PubMed + + + AA0376#CYS + RESID + + + This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381. + + + DiffAvg + 1738.88 + + + + DiffFormula + C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1 + + + + DiffMono + 1738.947820 + + + + Formula + C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1 + + + + MassAvg + 1842.02 + + + + MassMono + 1841.957004 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00746 + MOD:00748 + MOD:00905 + PSI-MOD + + + MOD:01470 + (E)-dehydrobutyrine (Thr) + + A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine. + + 0 + DeltaMass + + + 1547888 + PubMed + + + 20805503 + PubMed + + + 3769923 + PubMed + + + AA0547 + RESID + + + PSI-MOD-slim + + (2E)-2-aminobut-2-enoic acid + RESID-systematic + + + (E)-2-amino-2-butenoic acid + RESID-alternate + + + (E)-2-aminobutenoic acid + RESID-alternate + + + (E)-dehydrobutyrine + RESID-name + + + (E)dHAbu + PSI-MOD-label + + + 2,3-didehydrobutyrine + RESID-alternate + + + 3-methyldehydroalanine + RESID-alternate + + + alpha,beta-dehydroaminobutyric acid + RESID-alternate + + + anhydrothreonine + RESID-alternate + + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + Dehydroamino butyric acid + DeltaMass-label + + + Dhb + RESID-alternate + + + methyl-dehydroalanine + RESID-alternate + + + MOD_RES (E)-2,3-didehydrobutyrine + UniProt-feature + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00190 + PSI-MOD + + + MOD:01471 + (Z)-dehydrobutyrine (Thr) + + A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine. + + 0 + DeltaMass + + + 1547888 + PubMed + + + 3769923 + PubMed + + + AA0182 + RESID + + + PSI-MOD-slim + + (2Z)-2-aminobut-2-enoic acid + RESID-systematic + + + (Z)-2-amino-2-butenoic acid + RESID-alternate + + + (Z)-2-aminobutenoic acid + RESID-alternate + + + (Z)-dehydrobutyrine + RESID-name + + + (Z)dHAbu + PSI-MOD-label + + + 2,3-didehydrobutyrine + RESID-alternate + + + 3-methyldehydroalanine + RESID-alternate + + + alpha,beta-dehydroaminobutyric acid + RESID-alternate + + + anhydrothreonine + RESID-alternate + + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + Dehydroamino butyric acid + DeltaMass-label + + + Dhb + RESID-alternate + + + methyl-dehydroalanine + RESID-alternate + + + MOD_RES (Z)-2,3-didehydrobutyrine + UniProt-feature + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00190 + PSI-MOD + + + MOD:01472 + reduced residue + + A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + + RedRes + PSI-MOD-label + + MOD:01156 + PSI-MOD + + + MOD:01473 + hydrogenated residue + + A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + HRes + PSI-MOD-label + + MOD:01472 + PSI-MOD + + + MOD:01474 + O-[S-(carboxymethyl)phosphopantetheine]-L-serine + + A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine. + + 18688235 + PubMed + + + This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG]. + + + DiffAvg + 398.37 + + + + DiffFormula + C 13 H 23 N 2 O 8 P 1 S 1 + + + + DiffMono + 398.091273 + + + + Formula + C 16 H 28 N 3 O 10 P 1 S 1 + + + + MassAvg + 485.44 + + + + MassMono + 485.123302 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00399 + MOD:00861 + MOD:00916 + + derives_from + MOD:001590 + + PSI-MOD + + + MOD:01475 + O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine + + A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine. + + 18688235 + PubMed + + + This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG]. + + + DiffAvg + 397.38 + + + + DiffFormula + C 13 H 24 N 3 O 7 P 1 S 1 + + + + DiffMono + 397.107258 + + + + Formula + C 16 H 29 N 4 O 9 P 1 S 1 + + + + MassAvg + 484.46 + + + + MassMono + 484.139286 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00861 + MOD:00916 + + derives_from + MOD:001590 + + PSI-MOD + + + MOD:01476 + 2'-fluoro-L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine. + + 18688235 + PubMed + + + 8172898 + PubMed + + + + 2-fluorophenylalanine + PSI-MOD-alternate + + + o-fluorophenylalanine + PSI-MOD-alternate + + + ortho-fluorophenylalanine + PSI-MOD-alternate + + + + DiffAvg + 17.99 + + + + DiffFormula + C 0 F 1 H -1 N 0 O 0 + + + + DiffMono + 17.990578 + + + + Formula + C 9 F 1 H 8 N 1 O 1 + + + + MassAvg + 165.17 + + + + MassMono + 165.058992 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:01227 + PSI-MOD + + + MOD:01477 + 3'-fluoro-L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine. + + 18688235 + PubMed + + + 8172898 + PubMed + + + + 3-fluorophenylalanine + PSI-MOD-alternate + + + m-fluorophenylalanine + PSI-MOD-alternate + + + meta-fluorophenylalanine + PSI-MOD-alternate + + + + DiffAvg + 17.99 + + + + DiffFormula + C 0 F 1 H -1 N 0 O 0 + + + + DiffMono + 17.990578 + + + + Formula + C 9 F 1 H 8 N 1 O 1 + + + + MassAvg + 165.17 + + + + MassMono + 165.058992 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:01227 + PSI-MOD + + + MOD:01478 + 4'-fluoro-L-phenylalanine + + A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine. + + 18688235 + PubMed + + + 8172898 + PubMed + + + + 4-fluorophenylalanine + PSI-MOD-alternate + + + p-fluorophenylalanine + PSI-MOD-alternate + + + para-fluorophenylalanine + PSI-MOD-alternate + + + rho-fluorophenylalanine + PSI-MOD-alternate + + + + DiffAvg + 17.99 + + + + DiffFormula + C 0 F 1 H -1 N 0 O 0 + + + + DiffMono + 17.990578 + + + + Formula + C 9 F 1 H 8 N 1 O 1 + + + + MassAvg + 165.17 + + + + MassMono + 165.058992 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:01227 + PSI-MOD + + + MOD:01479 + 4'-fluoro-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan. + + 18688235 + PubMed + + + 8172898 + PubMed + + + + 4-fluorotryptophan + PSI-MOD-alternate + + + + DiffAvg + 17.99 + + + + DiffFormula + F 1 H -1 + + + + DiffMono + 17.990578 + + + + Formula + C 11 F 1 H 9 N 2 O 1 + + + + MassAvg + 204.20 + + + + MassMono + 204.069891 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01226 + PSI-MOD + + + MOD:01480 + 5'-fluoro-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan. + + 18688235 + PubMed + + + 8172898 + PubMed + + + + 5-fluorotryptophan + PSI-MOD-alternate + + + + DiffAvg + 17.99 + + + + DiffFormula + F 1 H -1 + + + + DiffMono + 17.990578 + + + + Formula + C 11 F 1 H 9 N 2 O 1 + + + + MassAvg + 204.20 + + + + MassMono + 204.069891 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01226 + PSI-MOD + + + MOD:01481 + 6'-fluoro-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan. + + 18688235 + PubMed + + + 8172898 + PubMed + + + + 6-fluorotryptophan + PSI-MOD-alternate + + + + DiffAvg + 17.99 + + + + DiffFormula + F 1 H -1 + + + + DiffMono + 17.990578 + + + + Formula + C 11 F 1 H 9 N 2 O 1 + + + + MassAvg + 204.20 + + + + MassMono + 204.069891 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01226 + PSI-MOD + + + MOD:01482 + calcium containing modified residue + + A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion. + + 18688235 + PubMed + + + PSI-MOD-slim + + CaRes + PSI-MOD-label + + MOD:00698 + PSI-MOD + + + MOD:01483 + O-formylated residue + + A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group. + + 18688235 + PubMed + + + + OFoRes + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 O 1 + + + + DiffMono + 27.994915 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00493 + MOD:00671 + PSI-MOD + + + MOD:01484 + N6-(L-isoglutamyl)-L-lysine (Glu) + + A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water. + + 21863 + ChEBI + + + 19015515 + PubMed + + + AA0124#GLU + RESID + + + Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP. + + (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid + RESID-systematic + + + 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid + RESID-alternate + + + 5-glutamyl N6-lysine + RESID-alternate + + + N alpha -(gamma-Glutamyl)-lysine + DeltaMass-label + + + N(epsilon)-(gamma-glutamyl)lysine + RESID-alternate + + + N6-(L-isoglutamyl)-L-lysine + RESID-name + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 11 H 17 N 3 O 3 + + + + MassAvg + 239.27 + + + + MassMono + 239.126991 + + + + Origin + K, E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + MOD:00954 + MOD:01630 + PSI-MOD + + + MOD:01485 + iTRAQ4plex-114 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 532 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 114 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ114 + UniMod-interim + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01430 + MOD:01516 + MOD:01518 + PSI-MOD + + + MOD:01486 + iTRAQ4plex-114 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 532#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 114 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ114 + UniMod-interim + + + iTRAQ114nterm + OMSSA-label + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01485 + MOD:01711 + PSI-MOD + + + MOD:01487 + iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 532#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 114 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ114 + UniMod-interim + + + iTRAQ114K + OMSSA-label + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + (12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1 + + + + MassAvg + 272.20 + + + + MassMono + 272.200882 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01485 + MOD:01709 + MOD:01875 + PSI-MOD + + + MOD:01488 + iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 532#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 114 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ114 + UniMod-interim + + + iTRAQ114Y + OMSSA-label + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + (12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1 + + + + MassAvg + 307.17 + + + + MassMono + 307.169248 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01485 + MOD:01713 + PSI-MOD + + + MOD:01489 + iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + (12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1 + + + + MassAvg + 281.16 + + + + MassMono + 281.164831 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01485 + MOD:01709 + PSI-MOD + + + MOD:01490 + iTRAQ4plex-114 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + (12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1 + + + + MassAvg + 231.14 + + + + MassMono + 231.137947 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01485 + MOD:01713 + PSI-MOD + + + MOD:01491 + iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex114 + PSI-MS-label + + + + DiffAvg + 144.11 + + + + DiffFormula + (12)C 5 (13)C 2 H 12 N 2 (18)O 1 + + + + DiffMono + 144.105919 + + + + Formula + (12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1 + + + + MassAvg + 245.15 + + + + MassMono + 245.153598 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01485 + MOD:01713 + PSI-MOD + + + MOD:01492 + iTRAQ4plex-115 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 533 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ115 + UniMod-interim + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01430 + MOD:01516 + MOD:01518 + PSI-MOD + + + MOD:01493 + iTRAQ4plex-115 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 533#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ115 + UniMod-interim + + + iTRAQ115nterm + OMSSA-label + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01492 + MOD:01711 + PSI-MOD + + + MOD:01494 + iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 533#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ115 + UniMod-interim + + + iTRAQ115K + OMSSA-label + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + (12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1 + + + + MassAvg + 272.19 + + + + MassMono + 272.194562 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01492 + MOD:01709 + MOD:01875 + PSI-MOD + + + MOD:01495 + iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 533#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ115 + UniMod-interim + + + iTRAQ115Y + OMSSA-label + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + (12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1 + + + + MassAvg + 307.16 + + + + MassMono + 307.162928 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01492 + MOD:01713 + PSI-MOD + + + MOD:01496 + iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + (12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1 + + + + MassAvg + 281.16 + + + + MassMono + 281.158511 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01492 + MOD:01709 + PSI-MOD + + + MOD:01497 + iTRAQ4plex-115 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + (12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1 + + + + MassAvg + 231.13 + + + + MassMono + 231.131628 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01492 + MOD:01713 + PSI-MOD + + + MOD:01498 + iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex115 + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 + + + + DiffMono + 144.099599 + + + + Formula + (12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1 + + + + MassAvg + 245.15 + + + + MassMono + 245.147278 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01492 + MOD:01713 + PSI-MOD + + + MOD:01499 + iTRAQ4plex-116 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 214 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ4plex + PSI-MS-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01517 + MOD:01518 + PSI-MOD + + + MOD:01500 + iTRAQ4plex-116 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 214#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ116nterm + OMSSA-label + + + iTRAQ4plex + PSI-MS-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01499 + MOD:01711 + PSI-MOD + + + MOD:01501 + iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 214#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ116K + OMSSA-label + + + iTRAQ4plex + PSI-MS-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1 + + + + MassAvg + 272.20 + + + + MassMono + 272.197025 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01499 + MOD:01709 + MOD:01875 + PSI-MOD + + + MOD:01502 + iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 214#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ116Y + OMSSA-label + + + iTRAQ4plex + PSI-MS-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1 + + + + MassAvg + 307.17 + + + + MassMono + 307.165391 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01499 + MOD:01713 + PSI-MOD + + + MOD:01503 + iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2 + + + + MassAvg + 281.16 + + + + MassMono + 281.160974 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01499 + MOD:01709 + PSI-MOD + + + MOD:01504 + iTRAQ4plex-116 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3 + + + + MassAvg + 231.13 + + + + MassMono + 231.134091 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01499 + MOD:01713 + PSI-MOD + + + MOD:01505 + iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3 + + + + MassAvg + 245.15 + + + + MassMono + 245.149741 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01499 + MOD:01713 + PSI-MOD + + + MOD:01506 + iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 214 + UniMod + + + 889 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ4plex + PSI-MS-label + + + mTRAQ heavy + UniMod-description + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01517 + MOD:01518 + MOD:01863 + PSI-MOD + + + MOD:01507 + iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 214#N-term + UniMod + + + 889N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ117nterm + OMSSA-label + + + iTRAQ4plex + PSI-MS-label + + + mTRAQ heavy + UniMod-description + + + mTRAQ heavy on nterm + OMSSA-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01506 + MOD:01711 + PSI-MOD + + + MOD:01508 + iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 214#K + UniMod + + + 889#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ117K + OMSSA-label + + + iTRAQ4plex + PSI-MS-label + + + mTRAQ heavy + UniMod-description + + + mTRAQ heavy on K + OMSSA-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1 + + + + MassAvg + 272.20 + + + + MassMono + 272.197025 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01506 + MOD:01709 + MOD:01875 + PSI-MOD + + + MOD:01509 + iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 214#Y + UniMod + + + 889#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + iTRAQ + UniMod-interim + + + iTRAQ117Y + OMSSA-label + + + iTRAQ4plex + PSI-MS-label + + + mTRAQ heavy + UniMod-description + + + mTRAQ heavy on Y + OMSSA-label + + + Representative mass and accurate mass for 116 & 117 + UniMod-description + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1 + + + + MassAvg + 307.17 + + + + MassMono + 307.165391 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01506 + MOD:01713 + PSI-MOD + + + MOD:01510 + iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2 + + + + MassAvg + 281.16 + + + + MassMono + 281.160974 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01506 + MOD:01709 + PSI-MOD + + + MOD:01511 + iTRAQ4plex-117 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3 + + + + MassAvg + 231.13 + + + + MassMono + 231.134091 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01506 + MOD:01713 + PSI-MOD + + + MOD:01512 + iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + iTRAQ4plex + PSI-MS-label + + + + DiffAvg + 144.10 + + + + DiffFormula + (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 + + + + DiffMono + 144.102062 + + + + Formula + (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3 + + + + MassAvg + 245.15 + + + + MassMono + 245.149741 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01506 + MOD:01713 + PSI-MOD + + + MOD:01513 + modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da + + Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00538 + PSI-MOD + + + MOD:01514 + modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da + + Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01513 + PSI-MOD + + + MOD:01515 + modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da + + Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01514 + PSI-MOD + + + MOD:01516 + modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. + + Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01514 + PSI-MOD + + + MOD:01517 + modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da + + Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01515 + MOD:01516 + PSI-MOD + + + MOD:01518 + iTRAQ4plex reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. + + 214 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01705 + PSI-MOD + + + MOD:01519 + reporter fragment + + A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process. + + 18688235 + PubMed + + + The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present. + PSI-MOD-slim + MOD:01156 + PSI-MOD + + + MOD:01520 + modification reporter fragment + + A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01519 + PSI-MOD + + + MOD:01521 + iTRAQ4plex reporter fragment + + A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01520 + PSI-MOD + + + MOD:01522 + iTRAQ4plex-114 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 5 (13)C 1 H 13 (14)N 2 + + + + MassAvg + 114.11 + + + + MassMono + 114.110680 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01521 + + derives_from + MOD:014850 + + PSI-MOD + + + MOD:01523 + iTRAQ4plex-115 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1 + + + + MassAvg + 115.11 + + + + MassMono + 115.107715 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01521 + + derives_from + MOD:014920 + + PSI-MOD + + + MOD:01524 + iTRAQ4plex-116 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1 + + + + MassAvg + 116.11 + + + + MassMono + 116.111069 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01521 + + derives_from + MOD:014990 + + PSI-MOD + + + MOD:01525 + iTRAQ4plex-117, mTRAQ heavy, reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1 + + + + MassAvg + 117.11 + + + + MassMono + 117.114424 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01521 + MOD:01870 + + derives_from + MOD:015060 + + PSI-MOD + + + MOD:01526 + iTRAQ8plex reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. + + 730 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01705 + PSI-MOD + + + MOD:01527 + residue reporter fragment + + A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01519 + PSI-MOD + + + MOD:01528 + iTRAQ8plex-113 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 730 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01591 + PSI-MOD + + + MOD:01529 + iTRAQ8plex-113 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 730#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01528 + MOD:01712 + PSI-MOD + + + MOD:01530 + iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 730#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 + + + + MassAvg + 432.30 + + + + MassMono + 432.300322 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01528 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01531 + iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 730#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 467.27 + + + + MassMono + 467.268688 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01528 + MOD:01714 + PSI-MOD + + + MOD:01532 + iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.264271 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01528 + MOD:01710 + PSI-MOD + + + MOD:01533 + iTRAQ8plex-113 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 391.24 + + + + MassMono + 391.237388 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01528 + MOD:01714 + PSI-MOD + + + MOD:01534 + iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.253038 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01528 + MOD:01714 + PSI-MOD + + + MOD:01535 + iTRAQ8plex-114 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 730 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01591 + PSI-MOD + + + MOD:01536 + iTRAQ8plex-114 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 730#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01535 + MOD:01712 + PSI-MOD + + + MOD:01537 + iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 730#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 + + + + MassAvg + 432.30 + + + + MassMono + 432.300322 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01535 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01538 + iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 730#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 467.27 + + + + MassMono + 467.268688 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01535 + MOD:01714 + PSI-MOD + + + MOD:01539 + iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.264271 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01535 + MOD:01710 + PSI-MOD + + + MOD:01540 + iTRAQ8plex-114 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 391.24 + + + + MassMono + 391.237388 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01535 + MOD:01714 + PSI-MOD + + + MOD:01541 + iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.253038 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01535 + MOD:01714 + PSI-MOD + + + MOD:01542 + iTRAQ8plex-115 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 731 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01584 + PSI-MOD + + + MOD:01543 + iTRAQ8plex-115 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 731#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01542 + MOD:01712 + PSI-MOD + + + MOD:01544 + iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 731#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 + + + + MassAvg + 432.29 + + + + MassMono + 432.294002 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01542 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01545 + iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 731#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 467.26 + + + + MassMono + 467.262368 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01542 + MOD:01714 + PSI-MOD + + + MOD:01546 + iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.257951 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01542 + MOD:01710 + PSI-MOD + + + MOD:01547 + iTRAQ8plex-115 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 391.23 + + + + MassMono + 391.231068 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01542 + MOD:01714 + PSI-MOD + + + MOD:01548 + iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.246718 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01542 + MOD:01714 + PSI-MOD + + + MOD:01549 + iTRAQ8plex-116 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 730 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01591 + PSI-MOD + + + MOD:01550 + iTRAQ8plex-116 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 730#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01549 + MOD:01712 + PSI-MOD + + + MOD:01551 + iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 730#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 + + + + MassAvg + 432.30 + + + + MassMono + 432.300322 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01549 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01552 + iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 730#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 467.27 + + + + MassMono + 467.268688 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01549 + MOD:01714 + PSI-MOD + + + MOD:01553 + iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.264271 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01549 + MOD:01710 + PSI-MOD + + + MOD:01554 + iTRAQ8plex-116 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 391.24 + + + + MassMono + 391.237388 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01549 + MOD:01714 + PSI-MOD + + + MOD:01555 + iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.253038 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01549 + MOD:01714 + PSI-MOD + + + MOD:01556 + iTRAQ8plex-117 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 730 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01591 + PSI-MOD + + + MOD:01557 + iTRAQ8plex-117 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 730#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01556 + MOD:01712 + PSI-MOD + + + MOD:01558 + iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 730#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 + + + + MassAvg + 432.30 + + + + MassMono + 432.300322 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01556 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01559 + iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 730#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex + UniMod-interim + + + iTRAQ8plex:13C(7)15N(1) + UniMod-alternate + + + Representative mass and accurate mass for 113, 114, 116 & 117 + UniMod-description + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 467.27 + + + + MassMono + 467.268688 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01556 + MOD:01714 + PSI-MOD + + + MOD:01560 + iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.264271 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01556 + MOD:01710 + PSI-MOD + + + MOD:01561 + iTRAQ8plex-117 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 391.24 + + + + MassMono + 391.237388 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01556 + MOD:01714 + PSI-MOD + + + MOD:01562 + iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.21 + + + + DiffFormula + (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 + + + + DiffMono + 304.205359 + + + + Formula + (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.253038 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01556 + MOD:01714 + PSI-MOD + + + MOD:01563 + iTRAQ8plex-118 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 731 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01584 + PSI-MOD + + + MOD:01564 + iTRAQ8plex-118 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 731#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01563 + MOD:01712 + PSI-MOD + + + MOD:01565 + iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 731#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 + + + + MassAvg + 432.29 + + + + MassMono + 432.294002 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01563 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01566 + iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 731#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 467.26 + + + + MassMono + 467.262368 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01563 + MOD:01714 + PSI-MOD + + + MOD:01567 + iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.257951 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01563 + MOD:01710 + PSI-MOD + + + MOD:01568 + iTRAQ8plex-118 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 391.23 + + + + MassMono + 391.231068 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01563 + MOD:01714 + PSI-MOD + + + MOD:01569 + iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.246718 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01563 + MOD:01714 + PSI-MOD + + + MOD:01570 + iTRAQ8plex-119 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 731 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01584 + PSI-MOD + + + MOD:01571 + iTRAQ8plex-119 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 731#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01570 + MOD:01712 + PSI-MOD + + + MOD:01572 + iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 731#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 + + + + MassAvg + 432.29 + + + + MassMono + 432.294002 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01570 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01573 + iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 731#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 467.26 + + + + MassMono + 467.262368 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01570 + MOD:01714 + PSI-MOD + + + MOD:01574 + iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.257951 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01570 + MOD:01710 + PSI-MOD + + + MOD:01575 + iTRAQ8plex-119 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 391.23 + + + + MassMono + 391.231068 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01570 + MOD:01714 + PSI-MOD + + + MOD:01576 + iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.246718 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01570 + MOD:01714 + PSI-MOD + + + MOD:01577 + iTRAQ8plex-121 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 731 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01526 + MOD:01584 + PSI-MOD + + + MOD:01578 + iTRAQ8plex-121 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 731#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01577 + MOD:01712 + PSI-MOD + + + MOD:01579 + iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 731#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 + + + + MassAvg + 432.29 + + + + MassMono + 432.294002 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01577 + MOD:01710 + MOD:01875 + PSI-MOD + + + MOD:01580 + iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 731#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Accurate mass for 115, 118, 119 & 121 + UniMod-description + + + Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry + UniMod-alternate + + + iTRAQ8plex:13C(6)15N(2) + UniMod-interim + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 467.26 + + + + MassMono + 467.262368 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01577 + MOD:01714 + PSI-MOD + + + MOD:01581 + iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 + + + + MassAvg + 441.26 + + + + MassMono + 441.257951 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01577 + MOD:01710 + PSI-MOD + + + MOD:01582 + iTRAQ8plex-121 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 391.23 + + + + MassMono + 391.231068 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01577 + MOD:01714 + PSI-MOD + + + MOD:01583 + iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + 304.20 + + + + DiffFormula + (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 + + + + DiffMono + 304.199039 + + + + Formula + (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 + + + + MassAvg + 405.25 + + + + MassMono + 405.246718 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01577 + MOD:01714 + PSI-MOD + + + MOD:01584 + modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da + + Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01515 + MOD:01592 + PSI-MOD + + + MOD:01585 + O-glycyl-L-serine + + A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine. + + 17502423 + PubMed + + + AA0495 + RESID + + + Cross-link 2. + + (2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid + RESID-systematic + + + O-(glycyl)-L-serine + RESID-name + + + O3-(aminoacetyl)serine + RESID-alternate + + + serine glycinate ester + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 7 N 2 O 3 + + + + MassAvg + 143.12 + + + + MassMono + 143.045667 + + + + Origin + G, S + + + + Source + natural + + + + TermSpec + C-term + + MOD:00885 + MOD:00908 + MOD:00916 + MOD:00954 + PSI-MOD + + + MOD:01586 + O-glycyl-L-threonine + + A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine. + + 17502423 + PubMed + + + AA0496 + RESID + + + Cross-link 2. + + (2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid + RESID-systematic + + + O-(glycyl)-L-threonine + RESID-name + + + O3-(2-aminoacetyl)threonine + RESID-alternate + + + threonine glycinate ester + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 9 N 2 O 3 + + + + MassAvg + 157.15 + + + + MassMono + 157.061317 + + + + Origin + G, T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00885 + MOD:00908 + MOD:00917 + MOD:00954 + PSI-MOD + + + MOD:01587 + O-(2-aminoethylphosphoryl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine. + + 15249686 + PubMed + + + 16825186 + PubMed + + + 16949362 + PubMed + + + AA0497 + RESID + + + + (2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid + RESID-systematic + + + MOD_RES O-(2-aminoethylphosphoryl)serine + UniProt-feature + + + O-(2-aminoethylphosphoryl)-L-serine + RESID-name + + + O3-(2-aminoethylphosphoryl)-L-serine + RESID-alternate + + + O3-(phosphoethanolamine)-L-serine + RESID-alternate + + + serine ethanolamine phosphate + RESID-alternate + + + serine ethanolamine phosphodiester + RESID-alternate + + + + DiffAvg + 123.05 + + + + DiffFormula + C 2 H 6 N 1 O 3 P 1 + + + + DiffMono + 123.008530 + + + + Formula + C 5 H 11 N 2 O 5 P 1 + + + + MassAvg + 210.13 + + + + MassMono + 210.040558 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:01588 + O-cholinephosphoryl-L-serine + + A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine. + + 15249686 + PubMed + + + 16825186 + PubMed + + + 16949362 + PubMed + + + AA0498 + RESID + + + + 2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium + RESID-systematic + + + 2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium + RESID-alternate + + + MOD_RES O-(2-cholinephosphoryl)serine + UniProt-feature + + + O-cholinephosphoryl-L-serine + RESID-name + + + O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine + RESID-alternate + + + O3-phosphocholine-L-serine + RESID-alternate + + + serine choline phosphate + RESID-alternate + + + serine choline phosphodiester + RESID-alternate + + + + DiffAvg + 166.14 + + + + DiffFormula + C 5 H 13 N 1 O 3 P 1 + + + + DiffMono + 166.062756 + + + + FormalCharge + 1+ + + + + Formula + C 8 H 18 N 2 O 5 P 1 + + + + MassAvg + 253.21 + + + + MassMono + 253.094785 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00861 + MOD:00916 + PSI-MOD + + + MOD:01589 + O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine. + + 15249686 + PubMed + + + 16949362 + PubMed + + + AA0499 + RESID + + + + (2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid + RESID-systematic + + + DADDGlc + RESID-alternate + + + O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine + RESID-alternate + + + O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine + RESID-name + + + O-[2,4-bis(acetylamino)]glucosyl-L-serine + RESID-alternate + + + O-seryl-beta-2,4-bis(acetylamino)glucoside + RESID-alternate + + + O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine + RESID-alternate + + + + DiffAvg + 244.25 + + + + DiffFormula + C 10 H 16 N 2 O 5 + + + + DiffMono + 244.105922 + + + + Formula + C 13 H 21 N 3 O 7 + + + + MassAvg + 331.33 + + + + MassMono + 331.137950 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:01590 + 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. + + 52950 + ChEBI + + + 18323630 + PubMed + + + AA0500 + RESID + + + + (2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid + RESID-systematic + + + 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan + RESID-name + + + LIPID 3'-farnesyl-2',N2-cyclotryptophan + UniProt-feature + + + + DiffAvg + 204.36 + + + + DiffFormula + C 15 H 24 N 0 O 0 + + + + DiffMono + 204.187801 + + + + Formula + C 26 H 34 N 2 O 1 + + + + MassAvg + 390.57 + + + + MassMono + 390.267114 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00437 + MOD:00601 + MOD:01115 + PSI-MOD + + + MOD:01591 + modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da + + Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01515 + MOD:01592 + PSI-MOD + + + MOD:01592 + modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da + + Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01514 + PSI-MOD + + + MOD:01593 + iTRAQ8plex reporter fragment + + A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + MOD:01520 + PSI-MOD + + + MOD:01594 + iTRAQ8plex-113 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 6 H 13 (14)N 2 + + + + MassAvg + 113.11 + + + + MassMono + 113.107325 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015280 + + PSI-MOD + + + MOD:01595 + iTRAQ8plex-114 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 5 (13)C 1 H 13 (14)N 2 + + + + MassAvg + 114.11 + + + + MassMono + 114.110680 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015350 + + PSI-MOD + + + MOD:01596 + iTRAQ8plex-115 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1 + + + + MassAvg + 115.11 + + + + MassMono + 115.107715 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015420 + + PSI-MOD + + + MOD:01597 + iTRAQ8plex-116 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1 + + + + MassAvg + 116.11 + + + + MassMono + 116.111069 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015490 + + PSI-MOD + + + MOD:01598 + iTRAQ8plex-117 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1 + + + + MassAvg + 117.11 + + + + MassMono + 117.114424 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015560 + + PSI-MOD + + + MOD:01599 + iTRAQ8plex-118 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 3 (13)C 3 H 13 (15)N 2 + + + + MassAvg + 118.11 + + + + MassMono + 118.111459 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015630 + + PSI-MOD + + + MOD:01600 + iTRAQ8plex-119 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 2 (13)C 4 H 13 (15)N 2 + + + + MassAvg + 119.11 + + + + MassMono + 119.114814 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015700 + + PSI-MOD + + + MOD:01601 + iTRAQ8plex-121 reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (13)C 6 H 13 (15)N 2 + + + + MassAvg + 121.12 + + + + MassMono + 121.121524 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01593 + + derives_from + MOD:015770 + + PSI-MOD + + + MOD:01602 + S-(L-lysyl)-L-methionine sulfilimine + + A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine. + + 12011424 + PubMed + + + 15951440 + PubMed + + + 19729652 + PubMed + + + AA0501 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid + RESID-systematic + + + (E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine + RESID-alternate + + + S-(L-lysyl)-L-methionine sulfilimine + RESID-name + + + S-lysyl-methionine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 11 H 19 N 3 O 2 S 1 + + + + MassAvg + 257.35 + + + + MassMono + 257.119798 + + + + Origin + K, M + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:00913 + PSI-MOD + + + MOD:01603 + 2x(15)N labeled L-lysine + + A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine. + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 1.99 + + + + DiffFormula + (14)N -2 (15)N 2 + + + + DiffMono + 1.994070 + + + + Formula + C 6 H 12 (15)N 2 O 1 + + + + MassAvg + 130.09 + + + + MassMono + 130.089033 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00843 + MOD:00912 + PSI-MOD + + + MOD:01604 + 4x(15)N labeled L-arginine + + A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine. + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 3.99 + + + + DiffFormula + (14)N -4 (15)N 4 + + + + DiffMono + 3.988140 + + + + Formula + C 6 H 12 (15)N 4 O 1 + + + + MassAvg + 160.09 + + + + MassMono + 160.089251 + + + + Origin + R + + + + Source + artifact + + + + TermSpec + none + + MOD:00843 + MOD:00902 + PSI-MOD + + + MOD:01605 + 5-glutamyl 2-aminoadipic acid + + A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid. + + 19620981 + PubMed + + + AA0502 + RESID + + + + (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid + RESID-systematic + + + 5-glutamyl 2-aminoadipic acid + RESID-name + + + MOD_RES 5-glutamyl 2-aminoadipic acid + UniProt-feature + + + N2-(gamma-glutamyl)-2-aminoadipic acid + RESID-alternate + + + N2-(isoglutamyl)-2-aminoadipic acid + RESID-alternate + + + + DiffAvg + 143.14 + + + + DiffFormula + C 6 H 9 N 1 O 3 + + + + DiffMono + 143.058243 + + + + Formula + C 11 H 16 N 2 O 6 + + + + MassAvg + 272.26 + + + + MassMono + 272.100836 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00674 + MOD:00906 + PSI-MOD + + + MOD:01606 + 5-glutamyl 2-aminoadipic 6-phosphoric anhydride + + A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride. + + 19620981 + PubMed + + + AA0503 + RESID + + + + (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid + RESID-systematic + + + 5-glutamyl 2-aminoadipic 6-phosphoric anhydride + RESID-name + + + + DiffAvg + 223.12 + + + + DiffFormula + C 6 H 10 N 1 O 6 P 1 + + + + DiffMono + 223.024574 + + + + Formula + C 11 H 17 N 2 O 9 P 1 + + + + MassAvg + 352.24 + + + + MassMono + 352.067167 + + + + Origin + E + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00674 + MOD:00861 + MOD:00906 + PSI-MOD + + + MOD:01607 + 5-glutamyl allysine + + A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine. + + 19620981 + PubMed + + + AA0504 + RESID + + + + (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid + RESID-systematic + + + 2-(5-glutamyl)amino-6-oxohexanoic acid + RESID-alternate + + + 5-glutamyl allysine + RESID-name + + + alpha-(gamma-glutamyl)allysine + RESID-alternate + + + N2-(gamma-glutamyl)allysine + RESID-alternate + + + N2-(isoglutamyl)allysine + RESID-alternate + + + + DiffAvg + 127.14 + + + + DiffFormula + C 6 H 9 N 1 O 2 + + + + DiffMono + 127.063329 + + + + Formula + C 11 H 16 N 2 O 5 + + + + MassAvg + 256.26 + + + + MassMono + 256.105922 + + + + Origin + E + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00674 + MOD:00906 + PSI-MOD + + + MOD:01608 + N2-(L-isoglutamyl)-L-lysine + + A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link. + + 19620981 + PubMed + + + AA0505 + RESID + + + + (2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid + RESID-systematic + + + 5-glutamyl N2-lysine + RESID-alternate + + + alpha-(gamma-glutamyl)lysine + RESID-alternate + + + gamma-glutamyl N2-lysine + RESID-alternate + + + MOD_RES 5-glutamyl N2-lysine + UniProt-feature + + + N2-(gamma-glutamyl)lysine + RESID-alternate + + + N2-(L-isoglutamyl)-L-lysine + RESID-name + + + + DiffAvg + 128.18 + + + + DiffFormula + C 6 H 12 N 2 O 1 + + + + DiffMono + 128.094963 + + + + Formula + C 11 H 19 N 3 O 4 + + + + MassAvg + 257.29 + + + + MassMono + 257.137556 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + PSI-MOD + + + MOD:01609 + 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan. + + 19584055 + PubMed + + + AA0506 + RESID + + + + (2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid + RESID-systematic + + + 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan + RESID-name + + + MOD_RES 7'-hydroxytryptophan + UniProt-feature + + + + DiffAvg + 178.14 + + + + DiffFormula + C 6 H 10 N 0 O 6 + + + + DiffMono + 178.047738 + + + + Formula + C 17 H 20 N 2 O 7 + + + + MassAvg + 364.35 + + + + MassMono + 364.127051 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00918 + + has_functional_parent + MOD:002220 + + + has_functional_parent + MOD:016640 + + PSI-MOD + + + MOD:01610 + L-threonine methyl ester + + A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester. + + 19745839 + PubMed + + + AA0507 + RESID + + + + L-threonine methyl ester + RESID-name + + + methyl (2S,3R)-2-amino-3-hydroxybutanoate + RESID-systematic + + + methyl L-threoninate + RESID-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 5 H 10 N 1 O 3 + + + + MassAvg + 132.14 + + + + MassMono + 132.066068 + + + + Origin + T + + + + Source + natural + + + + TermSpec + C-term + + MOD:01689 + MOD:01803 + PSI-MOD + + + MOD:01611 + 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN + + A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN. + + 17935335 + PubMed + + + AA0508 + RESID + + + Cross-link 2. + PSI-MOD-slim + + 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate + RESID-systematic + + + 6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN + RESID-alternate + + + 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN + RESID-alternate + + + 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN + RESID-alternate + + + 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN + RESID-alternate + + + 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN + RESID-name + + + BINDING FMN (covalent; via 2 links) + UniProt-feature + + + BINDING FMN (covalent; via 2 links, pros nitrogen) + UniProt-feature + + + + DiffAvg + 452.32 + + + + DiffFormula + C 17 H 17 N 4 O 9 P 1 S 0 + + + + DiffMono + 452.073315 + + + + Formula + C 26 H 29 N 8 O 11 P 1 S 1 + + + + MassAvg + 692.60 + + + + MassMono + 692.141411 + + + + Origin + C, H + + + + Source + natural + + + + TermSpec + none + + MOD:00896 + MOD:00905 + MOD:00909 + MOD:01621 + PSI-MOD + + + MOD:01612 + 3'-iodo-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine. + + 27847 + ChEBI + + + 8995307 + PubMed + + + AA0509 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid + RESID-systematic + + + 3'-iodo-L-tyrosine + RESID-name + + + 3-iodo-L-tyrosine + RESID-alternate + + + 3-iodotyrosine + RESID-alternate + + + 4-hydroxy-3-iodo-phenylalanine + RESID-alternate + + + MIT + RESID-alternate + + + MOD_RES Iodotyrosine + UniProt-feature + + + + DiffAvg + 125.90 + + + + DiffFormula + C 0 H -1 I 1 N 0 O 0 + + + + DiffMono + 125.896648 + + + + Formula + C 9 H 8 I 1 N 1 O 2 + + + + MassAvg + 289.07 + + + + MassMono + 288.959976 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:01228 + PSI-MOD + + + MOD:01613 + 3',5'-diiodo-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine. + + 15768 + ChEBI + + + 8995307 + PubMed + + + AA0510 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid + RESID-systematic + + + 3',5'-diiodo-L-tyrosine + RESID-name + + + 3,5-diiodo-L-tyrosine + RESID-alternate + + + 3,5-diiodotyrosine + RESID-alternate + + + DIT + RESID-alternate + + + iodogorgoic acid + RESID-alternate + + + MOD_RES Diiodotyrosine + UniProt-feature + + + + DiffAvg + 251.79 + + + + DiffFormula + C 0 H -2 I 2 N 0 O 0 + + + + DiffMono + 251.793295 + + + + Formula + C 9 H 7 I 2 N 1 O 2 + + + + MassAvg + 414.97 + + + + MassMono + 414.856624 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:01140 + PSI-MOD + + + MOD:01614 + glycyl phospho-5'-adenosine + + A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine. + + 16388576 + PubMed + + + 9632726 + PubMed + + + AA0511 + RESID + + + + (2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid + RESID-alternate + + + ([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate + RESID-alternate + + + 5'-adenylic-glyinate + RESID-alternate + + + aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate + RESID-systematic + + + glycine monoanhydride with 5'-adenylic acid + RESID-alternate + + + glycyl 5'-adenylate + RESID-alternate + + + glycyl adenosine-5'-phosphate + RESID-alternate + + + glycyl phospho-5'-adenosine + RESID-name + + + glycyladenylate + RESID-alternate + + + MOD_RES Glycyl adenylate + UniProt-feature + + + + DiffAvg + 329.21 + + + + DiffFormula + C 10 H 12 N 5 O 6 P 1 + + + + DiffMono + 329.052520 + + + + Formula + C 12 H 16 N 6 O 8 P 1 + + + + MassAvg + 403.27 + + + + MassMono + 403.076723 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:00908 + MOD:01165 + PSI-MOD + + + MOD:01615 + glycyl cysteine dithioester + + A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester. + + 11438688 + PubMed + + + 16388576 + PubMed + + + AA0512 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid + RESID-systematic + + + 2-(glycyldithio)alanine + RESID-alternate + + + glycyl cysteine dithioester + RESID-name + + + S-glycyl cysteine persulfide + RESID-alternate + + + S-glycyl thiocysteine + RESID-alternate + + + thioglycine cysteine disulfide + RESID-alternate + + + + DiffAvg + 14.05 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 1 + + + + DiffMono + 13.961506 + + + + Formula + C 5 H 7 N 2 O 2 S 2 + + + + MassAvg + 191.24 + + + + MassMono + 190.994894 + + + + Origin + C, G + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00395 + MOD:00908 + MOD:00954 + PSI-MOD + + + MOD:01616 + trithiocystine + + A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine. + + 19438211 + PubMed + + + AA0513 + RESID + + + Cross-link 2. + + (2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid) + RESID-systematic + + + 3,3'-pentathiobisalanine + RESID-alternate + + + bis(2-amino-2-carboxyethyl)pentasulfide + RESID-alternate + + + trithiocystine + RESID-name + + + + DiffAvg + 94.16 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 3 + + + + DiffMono + 93.900563 + + + + Formula + C 6 H 8 N 2 O 2 S 5 + + + + MassAvg + 300.44 + + + + MassMono + 299.918933 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:01620 + PSI-MOD + + + MOD:01617 + O-(6-phosphomannosyl)-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine. + + 20044576 + PubMed + + + AA0514 + RESID + + + + (2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid + RESID-systematic + + + O-(6-phosphomannosyl)-L-threonine + RESID-name + + + O3-(6-phosphomannosyl)threonine + RESID-alternate + + + + DiffAvg + 242.12 + + + + DiffFormula + C 6 H 11 N 0 O 8 P 1 + + + + DiffMono + 242.019154 + + + + Formula + C 10 H 18 N 1 O 10 P 1 + + + + MassAvg + 343.22 + + + + MassMono + 343.066832 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00005 + MOD:00595 + PSI-MOD + + + MOD:01618 + L-alanyl-L-isoaspartyl cyclopeptide + + A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide. + + 19928958 + PubMed + + + 3207697 + PubMed + + + AA0515 + RESID + + + Cross-link 2. + + (2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid + RESID-systematic + + + 1,4.2-anhydro(L-alanyl-L-aspartic acid) + RESID-alternate + + + CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn) + UniProt-feature + + + L-alanyl-L-isoaspartyl cyclopeptide + RESID-name + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 7 H 9 N 2 O 3 + + + + MassAvg + 169.16 + + + + MassMono + 169.061317 + + + + Origin + A, N + + + + Source + natural + + + + TermSpec + N-term + + MOD:00688 + MOD:00901 + MOD:00903 + MOD:00946 + PSI-MOD + + + MOD:01619 + multisulfide crosslinked residues + + A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + MOD:00905 + PSI-MOD + + + MOD:01620 + polysulfide crosslinked residues + + A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms. + + 18688235 + PubMed + + + MOD:00860 + MOD:01619 + PSI-MOD + + + MOD:01621 + flavin crosslinked residues + + A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00033 + MOD:00697 + PSI-MOD + + + MOD:01622 + monohydroxylated tryptophan + + A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan. + + 35#W + UniMod + + + + Oxidation + PSI-MS-label + + + oxyw + OMSSA-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 11 H 10 N 2 O 2 + + + + MassAvg + 202.21 + + + + MassMono + 202.074228 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00918 + PSI-MOD + + + MOD:01623 + 1-thioglycine (C-terminal) + + A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine. + + 11463785 + PubMed + + + 19145231 + PubMed + + + 9367957 + PubMed + + + AA0265#var + RESID + + + PSI-MOD-slim + + + DiffAvg + 16.06 + + + + DiffFormula + C 0 H 0 N 0 O -1 S 1 + + + + DiffMono + 15.977156 + + + + Formula + C 2 H 3 N 1 S 1 + + + + MassAvg + 73.11 + + + + MassMono + 72.998620 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:01625 + PSI-MOD + + + MOD:01624 + (2-aminosuccinimidyl)acetic acid (Asn) + + A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia. + + 10801322 + PubMed + + + 2015294 + PubMed + + + AA0441#ASN + RESID + + + Cross-link 2. + PSI-MOD-slim + + (2-aminosuccinimidyl)acetic acid + RESID-name + + + (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid + RESID-alternate + + + [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid + RESID-systematic + + + anhydroaspartyl glycine + RESID-alternate + + + aspartimide glycine + RESID-alternate + + + CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly) + UniProt-feature + + + N-(2-aminosuccinyl)glycine + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 6 H 6 N 2 O 3 + + + + MassAvg + 154.13 + + + + MassMono + 154.037842 + + + + Origin + G, N + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00903 + MOD:00946 + MOD:01628 + PSI-MOD + + + MOD:01625 + 1-thioglycine + + A protein modification that effectively converts a glycine residue to 1-thioglycine. + + 11463785 + PubMed + + + 9367957 + PubMed + + + AA0265 + RESID + + + This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG]. + PSI-MOD-slim + + 1-thioglycine + RESID-name + + + 2-amino-1-sulfanylethanone + RESID-alternate + + + aminoethanethioic acid + RESID-systematic + + + aminothioacetic acid + RESID-alternate + + + Carboxy->Thiocarboxy + PSI-MS-label + + + MOD_RES 1-thioglycine + UniProt-feature + + + S(O)Gly + PSI-MOD-label + + + thiocarboxylic acid + UniMod-description + + + + DiffAvg + 16.06 + + + + DiffFormula + C 0 H 0 N 0 O -1 S 1 + + + + DiffMono + 15.977156 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + G + + + + Source + natural + + MOD:00749 + MOD:00908 + PSI-MOD + + + MOD:01626 + L-cystine + + A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine. + + 16283 + ChEBI + + + 1988019 + PubMed + + + 2001356 + PubMed + + + 2076469 + PubMed + + + 3083866 + PubMed + + + 366603 + PubMed + + + 7918467 + PubMed + + + 8344916 + PubMed + + + AA0025 + RESID + + + This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765). + PSI-MOD-slim + + (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) + RESID-systematic + + + 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid + RESID-misnomer + + + 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) + RESID-alternate + + + 3,3'-dithiobis(2-aminopropanoic acid) + RESID-alternate + + + 3,3'-dithiobisalanine + RESID-alternate + + + 3,3'-dithiodialanine + RESID-alternate + + + beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide + RESID-alternate + + + beta,beta'-dithiodialanine + RESID-alternate + + + bis(alpha-aminopropionic acid)-beta-disulfide + RESID-alternate + + + bis(beta-amino-beta-carboxyethyl)disulfide + RESID-alternate + + + Cys2 + PSI-MOD-label + + + Cystine ((Cys)2) + DeltaMass-label + + + dicysteine + RESID-alternate + + + L-cystine + RESID-name + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + none + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:01627 + L-cysteinyl-L-selenocysteine + + A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine. + + 12911312 + PubMed + + + 18688235 + PubMed + + + Cross-link 2. + PSI-MOD-slim + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 8 N 2 O 2 S 1 Se 1 + + + + MassAvg + 251.17 + + + + MassMono + 251.947170 + + + + Origin + C, X + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00859 + MOD:00905 + PSI-MOD + + + MOD:01628 + (2-aminosuccinimidyl)acetic acid + + A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue. + + 10801322 + PubMed + + + 18688235 + PubMed + + + Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. + PSI-MOD-slim + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 6 N 2 O 3 + + + + MassAvg + 154.13 + + + + MassMono + 154.037842 + + + + Origin + G, X + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00908 + MOD:01944 + PSI-MOD + + + MOD:01629 + cyclo[(prolylserin)-O-yl] cysteinate + + A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue. + + 7961166 + PubMed + + + AA0489 + RESID + + + + (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate + RESID-alternate + + + [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate + RESID-systematic + + + cyclo[(prolylserin)-O-yl] cysteinate + RESID-name + + + MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate + UniProt-feature + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 11 H 16 N 3 O 4 S 1 + + + + MassAvg + 286.33 + + + + MassMono + 286.086152 + + + + Origin + X + + + + Source + natural + + + + TermSpec + C-term + + MOD:00859 + MOD:00905 + PSI-MOD + + + MOD:01630 + N6-(L-isoglutamyl)-L-lysine + + A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine . + + 21863 + ChEBI + + + 0 + DeltaMass + + + 2461365 + PubMed + + + 5637041 + PubMed + + + 5656070 + PubMed + + + 8598899 + PubMed + + + AA0124 + RESID + + + Cross-link 2. + PSI-MOD-slim + + (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid + RESID-systematic + + + 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid + RESID-alternate + + + 5-glutamyl N6-lysine + RESID-alternate + + + N alpha -(gamma-Glutamyl)-lysine + DeltaMass-label + + + N(epsilon)-(gamma-glutamyl)lysine + RESID-alternate + + + N6-(L-isoglutamyl)-L-lysine + RESID-name + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 11 H 17 N 3 O 3 + + + + MassAvg + 239.27 + + + + MassMono + 239.126991 + + + + Origin + K, X + + + + Source + natural + + + + TermSpec + none + + MOD:00688 + MOD:00859 + MOD:01875 + PSI-MOD + + + MOD:01631 + L-alanine removal + + A protein modification that effectively removes or replaces an L-alanine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -71.08 + + + + DiffFormula + C -3 H -5 N -1 O -1 + + + + DiffMono + -71.037114 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + A + + + + Source + natural + + + + TermSpec + none + + MOD:00901 + MOD:01651 + PSI-MOD + + + MOD:01632 + L-arginine removal + + A protein modification that effectively removes or replaces an L-arginine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -156.19 + + + + DiffFormula + C -6 H -12 N -4 O -1 + + + + DiffMono + -156.101111 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00902 + MOD:01651 + PSI-MOD + + + MOD:01633 + L-asparagine removal + + A protein modification that effectively removes or replaces an L-asparagine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -114.10 + + + + DiffFormula + C -4 H -6 N -2 O -2 + + + + DiffMono + -114.042927 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00903 + MOD:01651 + PSI-MOD + + + MOD:01634 + L-aspartic acid removal + + A protein modification that effectively removes or replaces an L-aspartic acid. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -115.09 + + + + DiffFormula + C -4 H -5 N -1 O -3 + + + + DiffMono + -115.026943 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01651 + PSI-MOD + + + MOD:01635 + L-cysteine removal + + A protein modification that effectively removes or replaces an L-cysteine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -103.14 + + + + DiffFormula + C -3 H -5 N -1 O -1 S -1 + + + + DiffMono + -103.009185 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01651 + PSI-MOD + + + MOD:01636 + L-glutamic acid removal + + A protein modification that effectively removes or replaces an L-glutamic acid. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -129.12 + + + + DiffFormula + C -5 H -7 N -1 O -3 + + + + DiffMono + -129.042593 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + MOD:01651 + PSI-MOD + + + MOD:01637 + L-glutamine removal + + A protein modification that effectively removes or replaces an L-glutamine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -128.13 + + + + DiffFormula + C -5 H -8 N -2 O -2 + + + + DiffMono + -128.058578 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + MOD:01651 + PSI-MOD + + + MOD:01638 + glycine removal + + A protein modification that effectively removes or replaces a glycine. + + 18688235 + PubMed + + + This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -57.05 + + + + DiffFormula + C -2 H -3 N -1 O -1 + + + + DiffMono + -57.021464 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + G + + + + Source + natural + + + + TermSpec + none + + MOD:00908 + MOD:01651 + PSI-MOD + + + MOD:01639 + L-histidine removal + + A protein modification that effectively removes or replaces an L-histidine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -137.14 + + + + DiffFormula + C -6 H -7 N -3 O -1 + + + + DiffMono + -137.058912 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00909 + MOD:01651 + PSI-MOD + + + MOD:01640 + L-isoleucine removal + + A protein modification that effectively removes or replaces an L-isoleucine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -113.16 + + + + DiffFormula + C -6 H -11 N -1 O -1 + + + + DiffMono + -113.084064 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00910 + MOD:01651 + PSI-MOD + + + MOD:01641 + L-leucine removal + + A protein modification that effectively removes or replaces an L-leucine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -113.16 + + + + DiffFormula + C -6 H -11 N -1 O -1 + + + + DiffMono + -113.084064 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + L + + + + Source + natural + + + + TermSpec + none + + MOD:00911 + MOD:01651 + PSI-MOD + + + MOD:01642 + L-lysine removal + + A protein modification that effectively removes or replaces an L-lysine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -128.18 + + + + DiffFormula + C -6 H -12 N -2 O -1 + + + + DiffMono + -128.094963 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01651 + PSI-MOD + + + MOD:01643 + L-methionine removal + + A protein modification that effectively removes or replaces an L-methionine. + + 3327521 + PubMed + + + 765 + UniMod + + + This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG]. + PSI-MOD-slim + + Met-loss + UniMod-interim + + + ntermmcleave + OMSSA-label + + + + DiffAvg + -131.19 + + + + DiffFormula + C -5 H -9 N -1 O -1 S -1 + + + + DiffMono + -131.040485 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:00913 + MOD:01651 + PSI-MOD + + + MOD:01644 + L-phenylalanine removal + + A protein modification that effectively removes or replaces an L-phenylalanine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -147.18 + + + + DiffFormula + C -9 H -9 N -1 O -1 + + + + DiffMono + -147.068414 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + F + + + + Source + natural + + + + TermSpec + none + + MOD:00914 + MOD:01651 + PSI-MOD + + + MOD:01645 + L-proline removal + + A protein modification that effectively removes or replaces an L-proline. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -97.12 + + + + DiffFormula + C -5 H -7 N -1 O -1 + + + + DiffMono + -97.052764 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00915 + MOD:01651 + PSI-MOD + + + MOD:01646 + L-serine removal + + A protein modification that effectively removes or replaces an L-serine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -87.08 + + + + DiffFormula + C -3 H -5 N -1 O -2 + + + + DiffMono + -87.032028 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01651 + PSI-MOD + + + MOD:01647 + L-threonine removal + + A protein modification that effectively removes or replaces an L-threonine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -101.10 + + + + DiffFormula + C -4 H -7 N -1 O -2 + + + + DiffMono + -101.047678 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01651 + PSI-MOD + + + MOD:01648 + L-tryptophan removal + + A protein modification that effectively removes or replaces an L-tryptophan. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -186.21 + + + + DiffFormula + C -11 H -10 N -2 O -1 + + + + DiffMono + -186.079313 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:00918 + MOD:01651 + PSI-MOD + + + MOD:01649 + L-tyrosine removal + + A protein modification that effectively removes or replaces an L-tyrosine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -163.18 + + + + DiffFormula + C -9 H -9 N -1 O -2 + + + + DiffMono + -163.063329 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00919 + MOD:01651 + PSI-MOD + + + MOD:01650 + L-valine removal + + A protein modification that effectively removes or replaces an L-valine. + + 18688235 + PubMed + + + This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + DiffAvg + -99.13 + + + + DiffFormula + C -5 H -9 N -1 O -1 + + + + DiffMono + -99.068414 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + V + + + + Source + natural + + + + TermSpec + none + + MOD:00920 + MOD:01651 + PSI-MOD + + + MOD:01651 + natural, standard, encoded residue removal + + A protein modification that effectively removes or replaces a natural, standard, encoded residue. + + 18688235 + PubMed + + + This represents the loss or replacement of an encoded residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. + PSI-MOD-slim + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00009 + PSI-MOD + + + MOD:01652 + sulfonyl halide reagent derivatized residue + + A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent. + + 18688235 + PubMed + + + These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide. + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01653 + dansyl chloride derivatized residue + + A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride. + + 0 + DeltaMass + + + 139 + UniMod + + + + 5-dimethylaminonaphthalene-1-sulfonyl + UniMod-description + + + Dansyl + PSI-MS-label + + + Dansyl (Dns) + DeltaMass-label + + + DansylRes + PSI-MOD-label + + + + DiffAvg + 233.29 + + + + DiffFormula + C 12 H 11 N 1 O 2 S 1 + + + + DiffMono + 233.051050 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01652 + PSI-MOD + + + MOD:01654 + N6-Dansyl derivatized lysine + + A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine. + + 139#K + UniMod + + + + 5-dimethylaminonaphthalene-1-sulfonyl + UniMod-description + + + Dansyl + PSI-MS-label + + + N6DansylLys + PSI-MOD-label + + + + DiffAvg + 233.29 + + + + DiffFormula + C 12 H 11 N 1 O 2 S 1 + + + + DiffMono + 233.051050 + + + + Formula + C 18 H 23 N 3 O 3 S 1 + + + + MassAvg + 361.46 + + + + MassMono + 361.146013 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01653 + PSI-MOD + + + MOD:01655 + alpha-amino-Dansyl derivatized residue + + A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue. + + 139#N-term + UniMod + + + + 5-dimethylaminonaphthalene-1-sulfonyl + UniMod-description + + + Dansyl + PSI-MS-label + + + N2DansylRes + PSI-MOD-label + + + + DiffAvg + 233.29 + + + + DiffFormula + C 12 H 11 N 1 O 2 S 1 + + + + DiffMono + 233.051050 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01653 + PSI-MOD + + + MOD:01656 + Dabsyl chloride derivatized residue + + A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride. + + 18688235 + PubMed + + + + 4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl + PSI-MOD-alternate + + + DabsylRes + PSI-MOD-label + + + + DiffAvg + 287.34 + + + + DiffFormula + C 14 H 13 N 3 O 2 S 1 + + + + DiffMono + 287.072848 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01652 + PSI-MOD + + + MOD:01657 + N6-Dabsyl derivatized lysine + + A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine. + + 18688235 + PubMed + + + + N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine + PSI-MOD-alternate + + + N6DabsylLys + PSI-MOD-label + + + + DiffAvg + 287.34 + + + + DiffFormula + C 14 H 13 N 3 O 2 S 1 + + + + DiffMono + 287.072848 + + + + Formula + C 20 H 25 N 5 O 3 S 1 + + + + MassAvg + 415.51 + + + + MassMono + 415.167811 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01656 + PSI-MOD + + + MOD:01658 + alpha-amino-Dabsyl derivatized residue + + A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue. + + 18688235 + PubMed + + + + N2DabsylRes + PSI-MOD-label + + + + DiffAvg + 287.34 + + + + DiffFormula + C 14 H 13 N 3 O 2 S 1 + + + + DiffMono + 287.072848 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01656 + PSI-MOD + + + MOD:01659 + Uniblue A derivatized residue + + A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A. + + 18688235 + PubMed + + + This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues. + + 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid + PSI-MOD-alternate + + + 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid + PSI-MOD-alternate + + + Uniblue A + PSI-MOD-alternate + + + UniblueARes + PSI-MOD-label + + + + DiffAvg + 484.50 + + + + DiffFormula + C 22 H 16 N 2 O 7 S 2 + + + + DiffMono + 484.039893 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01660 + Uniblue A derivatized cysteine + + A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct. + + 18688235 + PubMed + + + PSI-MOD-slim + + 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate + PSI-MOD-alternate + + + 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate + PSI-MOD-alternate + + + SUniblueACys + PSI-MOD-label + + + Uniblue A + PSI-MOD-alternate + + + + DiffAvg + 484.50 + + + + DiffFormula + C 22 H 16 N 2 O 7 S 2 + + + + DiffMono + 484.039893 + + + + Formula + C 25 H 21 N 3 O 8 S 3 + + + + MassAvg + 587.64 + + + + MassMono + 587.049078 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + MOD:01659 + PSI-MOD + + + MOD:01661 + pyruvic acid (Tyr) + + A protein modification that effectively converts an L-tyrosine residue to pyruvic acid. + + 10085076 + PubMed + + + 3042771 + PubMed + + + 500639 + PubMed + + + 8464063 + PubMed + + + AA0127#TYR + RESID + + + + 2-oxopropanoic acid + RESID-systematic + + + MOD_RES Pyruvic acid (Tyr) + UniProt-feature + + + pyruvic acid + RESID-name + + + + DiffAvg + -93.13 + + + + DiffFormula + C -6 H -7 N -1 O 0 + + + + DiffMono + -93.057849 + + + + Formula + C 3 H 3 O 2 + + + + MassAvg + 71.06 + + + + MassMono + 71.013304 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + N-term + + MOD:00919 + MOD:01154 + PSI-MOD + + + MOD:01662 + N5-(ADP-ribosyl)-L-glutamine + + A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine. + + 20185726 + PubMed + + + AA0518 + RESID + + + + (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid + RESID-systematic + + + N5-(ADP-ribosyl)-L-glutamine + RESID-name + + + N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine + RESID-alternate + + + N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 20 H 29 N 7 O 15 P 2 + + + + MassAvg + 669.43 + + + + MassMono + 669.119687 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00907 + PSI-MOD + + + MOD:01663 + O-(ADP-ribosyl)-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine. + + 20185726 + PubMed + + + AA0519 + RESID + + + + (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid + RESID-systematic + + + O-(ADP-ribosyl)-L-threonine + RESID-name + + + O3-(ADP-ribosyl)-L-threonine + RESID-alternate + + + O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine + RESID-alternate + + + O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) + RESID-alternate + + + + DiffAvg + 541.30 + + + + DiffFormula + C 15 H 21 N 5 O 13 P 2 + + + + DiffMono + 541.061109 + + + + Formula + C 19 H 28 N 6 O 15 P 2 + + + + MassAvg + 642.41 + + + + MassMono + 642.108787 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00752 + MOD:00917 + PSI-MOD + + + MOD:01664 + 7'-hydroxy-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan. + + 20223990 + PubMed + + + AA0520 + RESID + + + + (2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 7'-hydroxy-L-tryptophan + RESID-name + + + 7-hydroxy-L-tryptophan + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 11 H 10 N 2 O 2 + + + + MassAvg + 202.21 + + + + MassMono + 202.074228 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:01622 + PSI-MOD + + + MOD:01665 + N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine + + A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine. + + 20185759 + PubMed + + + AA0521 + RESID + + + + (2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid + RESID-systematic + + + ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen + UniProt-feature + + + DNA glycosylase valine Schiff base intermediate + RESID-alternate + + + N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine + RESID-name + + + + DiffAvg + 178.08 + + + + DiffFormula + C 5 H 7 N 0 O 5 P 1 + + + + DiffMono + 178.003110 + + + + Formula + C 10 H 17 N 1 O 6 P 1 + + + + MassAvg + 278.22 + + + + MassMono + 278.079349 + + + + Origin + V + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00750 + MOD:00920 + PSI-MOD + + + MOD:01666 + epicocconone derivatized residue + + A protein modification that is produced by formation of an adduct with epicocconone. + + 18688235 + PubMed + + + + (6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione + PSI-MOD-alternate + + + Deep Purple + PSI-MOD-alternate + + + LavaPurple + PSI-MOD-alternate + + + Lightning Fast + PSI-MOD-alternate + + + + DiffAvg + 410.42 + + + + DiffFormula + C 23 H 22 O 7 + + + + DiffMono + 410.136553 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + PSI-MOD + + + MOD:01667 + N6-epicoccononyl lysine adduct + + A protein modification that is produced by formation of an adduct with epicocconone. + + 18688235 + PubMed + + + + (6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione + PSI-MOD-alternate + + + DeepPurple + PSI-MOD-alternate + + + LavaPurple + PSI-MOD-alternate + + + Lightning Fast + PSI-MOD-alternate + + + + DiffAvg + 410.42 + + + + DiffFormula + C 23 H 22 O 7 + + + + DiffMono + 410.136553 + + + + Formula + C 29 H 34 N 2 O 8 + + + + MassAvg + 538.60 + + + + MassMono + 538.231516 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01666 + PSI-MOD + + + MOD:01668 + O4-(8alpha-FAD)-L-aspartate + + A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate. + + 20080101 + PubMed + + + AA0522 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid + RESID-systematic + + + 8alpha-[(4-aspartyl)oxy]FAD + RESID-alternate + + + O4-(8alpha-FAD)-L-aspartate + RESID-name + + + + DiffAvg + 783.54 + + + + DiffFormula + C 27 H 31 N 9 O 15 P 2 + + + + DiffMono + 783.141485 + + + + Formula + C 31 H 36 N 10 O 18 P 2 + + + + MassAvg + 898.63 + + + + MassMono + 898.168428 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00895 + MOD:00904 + PSI-MOD + + + MOD:01669 + trimethyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine. + + 11704273 + PubMed + + + 602668 + PubMed + + + AA0523 + RESID + + + 37#R + UniMod + + + + (2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid + RESID-systematic + + + (2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid + RESID-alternate + + + 2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine + RESID-alternate + + + N(G)-trimethylarginine + RESID-alternate + + + N5-[(dimethylamino)(imino)methyl]ornithine + RESID-alternate + + + NoNoNo'Me3Arg + PSI-MOD-label + + + omega-N,omega-N,omega-N'-trimethyl-L-arginine + RESID-name + + + tri-Methylation + UniMod-description + + + Trimethyl + PSI-MS-label + + + trimethylationr + OMSSA-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 + + + + DiffMono + 42.046950 + + + + Formula + C 9 H 18 N 4 O 1 + + + + MassAvg + 198.27 + + + + MassMono + 198.148061 + + + + Origin + R + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00430 + MOD:00602 + MOD:00658 + PSI-MOD + + + MOD:01670 + N6-chloro-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. + + 16091367 + PubMed + + + 16195462 + PubMed + + + 17260957 + PubMed + + + AA0524 + RESID + + + + (2S)-2-amino-6-(chloroamino)hexanoic acid + RESID-systematic + + + epsilon-chlorolysine + RESID-alternate + + + lysine chloramine + RESID-alternate + + + N(zeta)-chlorolysine + RESID-alternate + + + N6-chloro-L-lysine + RESID-name + + + N6ClLys + PSI-MOD-label + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 6 Cl 1 H 11 N 2 O 1 + + + + MassAvg + 162.62 + + + + MassMono + 162.055991 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00912 + MOD:01672 + MOD:01911 + PSI-MOD + + + MOD:01671 + O-(L-isoaspartyl)-L-threonine (active site intermediate) + + A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia. + + 8706862 + PubMed + + + AA0525#THR + RESID + + + This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. + + (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid + RESID-alternate + + + ACT_SITE O-isoaspartyl threonine intermediate + UniProt-feature + + + O(beta)-(beta-aspartyl)threonine + RESID-alternate + + + O-(L-isoaspartyl)-L-threonine + RESID-name + + + O3-(isoaspartyl)-threonine + RESID-alternate + + + + DiffAvg + 115.09 + + + + DiffFormula + C 4 H 5 N 1 O 3 + + + + DiffMono + 115.026943 + + + + Formula + C 8 H 12 N 2 O 5 + + + + MassAvg + 216.19 + + + + MassMono + 216.074621 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00671 + MOD:01978 + PSI-MOD + + + MOD:01672 + halogenated lysine + + A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom. + + 18688235 + PubMed + + + + + Origin + K + + + + Source + none + + + + TermSpec + none + + MOD:00694 + PSI-MOD + + + MOD:01673 + N-acetylaminohexosylated residue + + A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond. + + 43 + UniMod + + + PSI-MOD-slim + + HexNAc + PSI-MS-label + + + HexNAcRes + PSI-MOD-label + + + N-Acetylhexosamine + UniMod-description + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00436 + PSI-MOD + + + MOD:01674 + N4-(N-acetylamino)hexosyl-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine. + + 43#N + UniMod + + + PSI-MOD-slim + + (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid + PSI-MOD-alternate + + + HexNAc + PSI-MS-label + + + HexNAcAsn + PSI-MOD-label + + + hexNAcN + OMSSA-label + + + N-Acetylhexosamine + UniMod-description + + + N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine + PSI-MOD-alternate + + + N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine + PSI-MOD-alternate + + + N4-(N-acetylhexosaminyl)asparagine + PSI-MOD-alternate + + + N4-asparagine-beta-N-acetylhexosaminide + PSI-MOD-alternate + + + N4-glycosyl-L-asparagine + PSI-MOD-alternate + + + N4-glycosylasparagine + PSI-MOD-alternate + + + N4HexNAcAsn + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 12 H 19 N 3 O 7 + + + + MassAvg + 317.30 + + + + MassMono + 317.122300 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00160 + MOD:01673 + PSI-MOD + + + MOD:01675 + O-(N-acetylamino)hexosyl-L-serine + + A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine. + + 43#S + UniMod + + + PSI-MOD-slim + + (S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid + PSI-MOD-alternate + + + HexNAc + PSI-MS-label + + + hexNAcS + OMSSA-label + + + N-Acetylhexosamine + UniMod-description + + + O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine + PSI-MOD-alternate + + + O-(N-acetylhexosaminyl)serine + PSI-MOD-alternate + + + O-glycosylserine + PSI-MOD-alternate + + + O-seryl-beta-N-acetylhexosaminide + PSI-MOD-alternate + + + O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine + PSI-MOD-alternate + + + OHexNAcSer + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 11 H 18 N 2 O 7 + + + + MassAvg + 290.27 + + + + MassMono + 290.111401 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + MOD:01673 + PSI-MOD + + + MOD:01676 + O-(N-acetylamino)hexosyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine. + + 43#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid + PSI-MOD-alternate + + + HexNAc + PSI-MS-label + + + hexNAcT + OMSSA-label + + + N-Acetylhexosamine + UniMod-description + + + O-(N-acetylhexcosaminyl)-L-threonine + PSI-MOD-alternate + + + O-glycosylthreonine + PSI-MOD-alternate + + + O3-(N-acetylhexosaminyl)threonine + PSI-MOD-alternate + + + OHexNAcThr + PSI-MOD-label + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 12 H 20 N 2 O 7 + + + + MassAvg + 304.30 + + + + MassMono + 304.127051 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00005 + MOD:01673 + PSI-MOD + + + MOD:01677 + O4-(N-acetylamino)hexosyl-L-hydroxyproline + + A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline. + + 18688235 + PubMed + + + secondary to RESID:AA0030 + PSI-MOD-slim + + (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid + PSI-MOD-alternate + + + 4-(N-acetylhexosaminyloxy)proline + PSI-MOD-alternate + + + 4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline + PSI-MOD-alternate + + + alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline + PSI-MOD-alternate + + + HexNAc + PSI-MS-label + + + O4-glycosyl-hydroxyproline + PSI-MOD-alternate + + + O4HexNAcHyPro + PSI-MOD-label + + + + DiffAvg + 219.19 + + + + DiffFormula + C 8 H 13 N 1 O 6 + + + + DiffMono + 219.074287 + + + + Formula + C 13 H 20 N 2 O 7 + + + + MassAvg + 316.31 + + + + MassMono + 316.127051 + + + + Origin + P + + + + Source + natural + + + + TermSpec + none + + MOD:00915 + MOD:01673 + PSI-MOD + + + MOD:01678 + N6-carbamoyl-L-lysine + + A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine. + + 56 + DeltaMass + + + 10978403 + PubMed + + + 12203680 + PubMed + + + 5#K + UniMod + + + This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG]. + PSI-MOD-slim + + 2-amino-6-ureido-hexanoic acid + PSI-MOD-alternate + + + Carbamyl + UniMod-interim + + + Carbamylation + UniMod-description + + + carbamylk + OMSSA-label + + + homocitrulline + PSI-MOD-alternate + + + N6-(aminocarbonyl)-L-lysine + PSI-MOD-alternate + + + N6CbmLys + PSI-MOD-label + + + + DiffAvg + 43.02 + + + + DiffFormula + C 1 H 1 N 1 O 1 + + + + DiffMono + 43.005814 + + + + Formula + C 7 H 13 N 3 O 2 + + + + MassAvg + 171.20 + + + + MassMono + 171.100777 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00398 + PSI-MOD + + + MOD:01679 + alpha-aminocarbamoylated residue + + A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group. + + 56 + DeltaMass + + + 10978403 + PubMed + + + 12203680 + PubMed + + + 5#N-term + UniMod + + + This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG]. + PSI-MOD-slim + + Carbamyl + UniMod-interim + + + Carbamylation + UniMod-description + + + N2CbmRes + PSI-MOD-label + + + ntermcarbamyl + OMSSA-label + + + + DiffAvg + 43.02 + + + + DiffFormula + C 1 H 1 N 1 O 1 + + + + DiffMono + 43.005814 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00398 + PSI-MOD + + + MOD:01680 + alpha-amino monomethylated residue + + A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group. + + 34#N-term + UniMod + + + Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. + PSI-MOD-slim + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + N2Me1Res + PSI-MOD-label + + + ntermmethyl + OMSSA-label + + + ntermpepmethyl + OMSSA-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00599 + MOD:01460 + PSI-MOD + + + MOD:01681 + monomethylated L-aspartic acid + + A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group. + + 34#D + UniMod + + + + Me1Asp + PSI-MOD-label + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + methyld + OMSSA-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 5 H 7 N 1 O 3 + + + + MassAvg + 129.12 + + + + MassMono + 129.042593 + + + + Origin + D + + + + Source + artifact + + + + TermSpec + none + + MOD:00599 + MOD:00887 + PSI-MOD + + + MOD:01682 + monomethylated L-cysteine + + A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group. + + 34#C + UniMod + + + PSI-MOD-slim + + Me1Cys + PSI-MOD-label + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + methylc + OMSSA-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 4 H 7 N 1 O 1 S 1 + + + + MassAvg + 117.17 + + + + MassMono + 117.024835 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00599 + MOD:00660 + PSI-MOD + + + MOD:01683 + monomethylated L-lysine + + A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group. + + PSI-MOD-slim + + Me1Lys + PSI-MOD-label + + + Methyl + PSI-MS-label + + + Methylation + UniMod-description + + + methylk + OMSSA-label + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 7 H 15 N 2 O 2 + + + + MassAvg + 159.21 + + + + MassMono + 159.113353 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00599 + MOD:00663 + PSI-MOD + + + MOD:01684 + palmitoylated-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine. + + 47 + UniMod + + + PSI-MOD-slim + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + palmitoylationc + OMSSA-label + + + PamCys + PSI-MOD-label + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + C 19 H 35 N 1 O 2 S 1 + + + + MassAvg + 341.55 + + + + MassMono + 341.238850 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00440 + MOD:00905 + PSI-MOD + + + MOD:01685 + alpha-amino palmitoylated residue + + A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group. + + 47#N-term + UniMod + + + PSI-MOD-slim + + N2PamRes + PSI-MOD-label + + + Palmitoyl + PSI-MS-label + + + Palmitoylation + UniMod-description + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00651 + MOD:01696 + PSI-MOD + + + MOD:01686 + alpha-amino dimethylated residue + + A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group. + + 36#N-term + UniMod + + + For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889. + + di-Methylation + UniMod-description + + + Dimethyl + PSI-MS-label + + + N2Me2Res + PSI-MOD-label + + + ntermpepdimethyl + OMSSA-label + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 + + + + DiffMono + 28.031300 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + N-term + + MOD:00429 + MOD:01460 + PSI-MOD + + + MOD:01687 + alpha-amino trimethylated residue + + A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group. + + 37#N-term + UniMod + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation. + PSI-MOD-slim + + N2Me3Res + PSI-MOD-label + + + ntermtrimethyl + OMSSA-label + + + tri-Methylation + UniMod-description + + + Trimethyl + PSI-MS-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 + + + + DiffMono + 42.046402 + + + + FormalCharge + 1+ + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00430 + MOD:01460 + + derives_from + MOD:017000 + + PSI-MOD + + + MOD:01688 + 3-hydroxy-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues. + + 35#N + UniMod + + + PSI-MOD-slim + + 3HyAsn + PSI-MOD-label + + + hydroxylationn + OMSSA-label + + + monohydroxylated asparagine + PSI-MOD-alternate + + + Oxidation + PSI-MS-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 4 H 6 N 2 O 3 + + + + MassAvg + 130.10 + + + + MassMono + 130.037842 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00903 + PSI-MOD + + + MOD:01689 + alpha-carboxyl methylated residue + + A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester. + + 34#C-term + UniMod + + + PSI-MOD-slim + + C1OMeRes + PSI-MOD-label + + + ctermpepmeester + OMSSA-label + + + ctermpepmethyl + OMSSA-label + + + Methyl + PSI-MS-label + + + Methyl + UniMod-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 S 0 + + + + DiffMono + 14.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + C-term + + MOD:00393 + PSI-MOD + + + MOD:01690 + N-[(12R)-12-hydroxymyristoyl]-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine. + + AA0516 + RESID + + + + 2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid + RESID-systematic + + + LIPID N-[(12R)-12-hydroxymyristoyl]cysteine + UniProt-feature + + + N-[(12R)-12-hydroxymyristoyl]-L-cysteine + RESID-name + + + N-[(12R)-12-hydroxytetradecanoyl]cysteine + RESID-alternate + + + + DiffAvg + 226.36 + + + + DiffFormula + C 14 H 26 N 0 O 2 S 0 + + + + DiffMono + 226.193280 + + + + Formula + C 17 H 32 N 1 O 3 S 1 + + + + MassAvg + 330.51 + + + + MassMono + 330.210290 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + MOD:01696 + PSI-MOD + + + MOD:01691 + N-(12-ketomyristoyl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine. + + 19053188 + PubMed + + + AA0517 + RESID + + + + 2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid + RESID-systematic + + + LIPID N-(12-oxomyristoyl)cysteine + UniProt-feature + + + N-(12-ketomyristoyl)-L-cysteine + RESID-name + + + N-(12-oxotetradecanoyl)cysteine + RESID-alternate + + + + DiffAvg + 224.34 + + + + DiffFormula + C 14 H 24 N 0 O 2 S 0 + + + + DiffMono + 224.177630 + + + + Formula + C 17 H 30 N 1 O 3 S 1 + + + + MassAvg + 328.49 + + + + MassMono + 328.194640 + + + + Origin + C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + MOD:01696 + PSI-MOD + + + MOD:01692 + glutamyl semialdehyde (Glu) + + A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde. + + 18688235 + PubMed + + + 743268 + PubMed + + + + Deoxy + PSI-MS-label + + + gamma-glutamyl semialdehyde + PSI-MOD-alternate + + + glutamyl 5-semialdehyde + PSI-MOD-alternate + + + glutamyl aldehyde + PSI-MOD-alternate + + + + DiffAvg + -16.00 + + + + DiffFormula + C 0 H 0 N 0 O -1 + + + + DiffMono + -15.994915 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + none + + MOD:00906 + MOD:01161 + MOD:01440 + PSI-MOD + + + MOD:01693 + alpha-amino pyridylacetylated residue + + A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group. + + 9276974 + PubMed + + + 25#N-term + UniMod + + + Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. + + ntermpeppyridyl + OMSSA-label + + + Pyridylacetyl + PSI-MS-label + + + pyridylacetyl + UniMod-description + + + + DiffAvg + 119.12 + + + + DiffFormula + C 7 H 5 N 1 O 1 + + + + DiffMono + 119.037114 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00418 + MOD:01696 + PSI-MOD + + + MOD:01694 + S-(coelenterazin-3a-yl)-L-cysteine + + A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine. + + 2311 + ChEBI + + + 18997450 + PubMed + + + AA0526 + RESID + + + + (2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid + RESID-systematic + + + dehydrocoelenterazine cysteine adduct + RESID-alternate + + + MOD_RES S-(coelenterazin-3a-yl)cysteine + UniProt-feature + + + S-(coelenterazin-3a-yl)-L-cysteine + RESID-name + + + symplectin chromophore + RESID-alternate + + + + DiffAvg + 421.46 + + + + DiffFormula + C 26 H 19 N 3 O 3 S 0 + + + + DiffMono + 421.142641 + + + + Formula + C 29 H 24 N 4 O 4 S 1 + + + + MassAvg + 524.60 + + + + MassMono + 524.151826 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + PSI-MOD + + + MOD:01695 + alpha-amino 3-(carboxamidomethylthio)propanoylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group. + + 15121203 + PubMed + + + 293#N-term + UniMod + + + + 3-(carbamidomethylthio)propanoyl + UniMod-description + + + CAMthiopropanoyl + PSI-MS-label + + + + DiffAvg + 145.18 + + + + DiffFormula + C 5 H 7 N 1 O 2 S 1 + + + + DiffMono + 145.019749 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00612 + MOD:01696 + PSI-MOD + + + MOD:01696 + alpha-amino acylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00670 + PSI-MOD + + + MOD:01697 + alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group. + + 235 + DeltaMass + + + 8597590 + PubMed + + + 276#N-term + UniMod + + + See the comment for MOD:00596 [JSG]. + + AEBS + PSI-MS-label + + + Aminoethylbenzenesulfonylation + UniMod-description + + + + DiffAvg + 183.23 + + + + DiffFormula + C 8 H 9 N 1 O 2 S 1 + + + + DiffMono + 183.035400 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00596 + PSI-MOD + + + MOD:01698 + alpha-amino trimethylated protonated-residue + + A protein modification that effectively replaces an amino group with a trimethylaminium group. + + 18688235 + PubMed + + + PSI-MOD-slim + + N2Me3+Res + PSI-MOD-label + + + tri-Methylation + UniMod-description + + + Trimethyl + PSI-MS-label + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 S 0 + + + + DiffMono + 43.054227 + + + + FormalCharge + 1+ + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:00711 + MOD:01460 + PSI-MOD + + + MOD:01699 + protonated residue + + A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + H+NRes + PSI-MOD-label + + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:01700 + alpha-amino protonated residue + + A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively. + + 18688235 + PubMed + + + PSI-MOD-slim + + N2H+NRes + PSI-MOD-label + + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + N-term + + MOD:01699 + PSI-MOD + + + MOD:01701 + deprotonated residue + + A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + H-NRes + PSI-MOD-label + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007276 + + + + FormalCharge + 1- + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01156 + PSI-MOD + + + MOD:01702 + alpha-carboxyl deprotonated residue + + A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion. + + 18688235 + PubMed + + + PSI-MOD-slim + + C1H-NRes + PSI-MOD-label + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 + + + + DiffMono + -1.007276 + + + + FormalCharge + 1- + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + C-term + + MOD:01701 + PSI-MOD + + + MOD:01703 + dehydrobutyrine + + A protein modification that effectively converts a source amino acid residue to dehydrobutyrine. + + 18688235 + PubMed + + + PSI-MOD-slim + + beta-elim-t + OMSSA-label + + + Dehydrated + PSI-MS-label + + + Dehydrated + UniMod-interim + + + Dehydration + UniMod-description + + + dehydro + OMSSA-label + + + Dehydroamino butyric acid + DeltaMass-label + + + dHAbu + PSI-MOD-label + + + phospholosst + OMSSA-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00859 + PSI-MOD + + + MOD:01704 + dehydrobutyrine (Met) + + A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide. + + 18688235 + PubMed + + + It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG]. + PSI-MOD-slim + + dHAbu(Met) + PSI-MOD-label + + + + DiffAvg + -48.10 + + + + DiffFormula + C -1 H -4 N 0 O 0 S -1 + + + + DiffMono + -48.003371 + + + + Formula + C 4 H 5 N 1 O 1 + + + + MassAvg + 83.09 + + + + MassMono + 83.037114 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00913 + MOD:01703 + PSI-MOD + + + MOD:01705 + isotope tagged reagent acylated residue + + A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:01706 + isotope tagged reagent N-acylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00670 + PSI-MOD + + + MOD:01707 + isotope tagged reagent O-acylated residue + + A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group. + + 18688235 + PubMed + + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00671 + PSI-MOD + + + MOD:01708 + isotope tagged reagent alpha-amino acylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01696 + MOD:01705 + MOD:01706 + PSI-MOD + + + MOD:01709 + iTRAQ4plex reporter+balance reagent N-acylated residue + + A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01706 + PSI-MOD + + + MOD:01710 + iTRAQ8plex reporter+balance reagent N-acylated residue + + A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01706 + PSI-MOD + + + MOD:01711 + iTRAQ4plex reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. + + 214#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01708 + MOD:01709 + PSI-MOD + + + MOD:01712 + iTRAQ8plex reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. + + 214#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01708 + MOD:01710 + PSI-MOD + + + MOD:01713 + iTRAQ4plex reporter+balance reagent O-acylated residue + + A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01707 + PSI-MOD + + + MOD:01714 + iTRAQ8plex reporter+balance reagent O-acylated residue + + A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01707 + PSI-MOD + + + MOD:01715 + TMT6plex reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group. + + 214 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01428 + MOD:01429 + MOD:01705 + PSI-MOD + + + MOD:01716 + TMT6plex reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + cysTMT6plex reporter fragment + PSI-MOD-alternate + + MOD:01520 + + derives_from + MOD:017150 + + + derives_from + MOD:018210 + + PSI-MOD + + + MOD:01717 + TMT6plex reporter+balance reagent N-acylated residue + + A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01706 + PSI-MOD + + + MOD:01718 + TMT6plex reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. + + 214#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01708 + MOD:01717 + PSI-MOD + + + MOD:01719 + TMT6plex reporter+balance reagent O-acylated residue + + A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01707 + PSI-MOD + + + MOD:01720 + TMT6plex-126 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 737 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01715 + PSI-MOD + + + MOD:01721 + TMT6plex-126 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 737#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01718 + MOD:01720 + PSI-MOD + + + MOD:01722 + TMT6plex-126 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 737#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 + + + + MassAvg + 357.26 + + + + MassMono + 357.257895 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01717 + MOD:01720 + MOD:01875 + PSI-MOD + + + MOD:01723 + TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 737#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 392.23 + + + + MassMono + 392.226261 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01719 + MOD:01720 + PSI-MOD + + + MOD:01724 + TMT6plex-126 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 + + + + MassAvg + 366.22 + + + + MassMono + 366.221844 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01717 + MOD:01720 + PSI-MOD + + + MOD:01725 + TMT6plex-126 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 316.19 + + + + MassMono + 316.194961 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01719 + MOD:01720 + PSI-MOD + + + MOD:01726 + TMT6plex-126 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 330.21 + + + + MassMono + 330.210611 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01719 + MOD:01720 + PSI-MOD + + + MOD:01727 + TMT6plex-126 reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + cysTMT6plex-126 reporter fragment + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 8 H 16 (14)N 1 + + + + MassAvg + 126.13 + + + + MassMono + 126.127726 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01716 + + derives_from + MOD:017200 + + + derives_from + MOD:018220 + + + derives_from + MOD:018230 + + PSI-MOD + + + MOD:01728 + TMT6plex-127 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 737 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01715 + PSI-MOD + + + MOD:01729 + TMT6plex-127 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 737#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01718 + MOD:01728 + PSI-MOD + + + MOD:01730 + TMT6plex-127 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 737#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 + + + + MassAvg + 357.26 + + + + MassMono + 357.257895 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01717 + MOD:01728 + MOD:01875 + PSI-MOD + + + MOD:01731 + TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 737#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + MassAvg + 229.16 + + + + MassMono + 229.162932 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01719 + MOD:01728 + PSI-MOD + + + MOD:01732 + TMT6plex-127 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 + + + + MassAvg + 366.22 + + + + MassMono + 366.221844 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01717 + MOD:01728 + PSI-MOD + + + MOD:01733 + TMT6plex-127 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 316.19 + + + + MassMono + 316.194961 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01719 + MOD:01728 + PSI-MOD + + + MOD:01734 + TMT6plex-127 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 330.21 + + + + MassMono + 330.210611 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01719 + MOD:01728 + PSI-MOD + + + MOD:01735 + TMT6plex-127 reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + cysTMT6plex-127 reporter fragment + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 7 (13)C 1 H 16 (14)N 1 + + + + MassAvg + 127.13 + + + + MassMono + 127.131081 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01716 + + derives_from + MOD:017280 + + + derives_from + MOD:018240 + + PSI-MOD + + + MOD:01736 + TMT6plex-128 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 737 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01715 + PSI-MOD + + + MOD:01737 + TMT6plex-128 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 737#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01718 + MOD:01736 + PSI-MOD + + + MOD:01738 + TMT6plex-128 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 737#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 + + + + MassAvg + 357.26 + + + + MassMono + 357.257895 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01717 + MOD:01736 + MOD:01875 + PSI-MOD + + + MOD:01739 + TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 737#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 392.23 + + + + MassMono + 392.226261 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01719 + MOD:01736 + PSI-MOD + + + MOD:01740 + TMT6plex-128 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 + + + + MassAvg + 366.22 + + + + MassMono + 366.221844 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01717 + MOD:01736 + PSI-MOD + + + MOD:01741 + TMT6plex-128 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 316.19 + + + + MassMono + 316.194961 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01719 + MOD:01736 + PSI-MOD + + + MOD:01742 + TMT6plex-128 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 330.21 + + + + MassMono + 330.210611 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01719 + MOD:01736 + PSI-MOD + + + MOD:01743 + TMT6plex-128 reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + cysTMT6plex-128 reporter fragment + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 6 (13)C 2 H 16 (14)N 1 + + + + MassAvg + 128.13 + + + + MassMono + 128.134436 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01716 + + derives_from + MOD:017360 + + + derives_from + MOD:018250 + + PSI-MOD + + + MOD:01744 + TMT6plex-129 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 737 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01715 + PSI-MOD + + + MOD:01745 + TMT6plex-129 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 737#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01718 + MOD:01744 + PSI-MOD + + + MOD:01746 + TMT6plex-129 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 737#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 + + + + MassAvg + 357.26 + + + + MassMono + 357.257895 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01717 + MOD:01744 + MOD:01875 + PSI-MOD + + + MOD:01747 + TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 737#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 392.23 + + + + MassMono + 392.226261 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01719 + MOD:01744 + PSI-MOD + + + MOD:01748 + TMT6plex-129 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 + + + + MassAvg + 366.22 + + + + MassMono + 366.221844 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01717 + MOD:01744 + PSI-MOD + + + MOD:01749 + TMT6plex-129 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 316.19 + + + + MassMono + 316.194961 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01719 + MOD:01744 + PSI-MOD + + + MOD:01750 + TMT6plex-129 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 330.21 + + + + MassMono + 330.210611 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01719 + MOD:01744 + PSI-MOD + + + MOD:01751 + TMT6plex-129 reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + cysTMT6plex-129 reporter fragment + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 5 (13)C 3 H 16 (14)N 1 + + + + MassAvg + 129.14 + + + + MassMono + 129.137790 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01716 + + derives_from + MOD:017440 + + + derives_from + MOD:018260 + + PSI-MOD + + + MOD:01752 + TMT6plex-130 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 737 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01715 + + derives_from + MOD:018270 + + PSI-MOD + + + MOD:01753 + TMT6plex-130 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 737#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01718 + MOD:01752 + PSI-MOD + + + MOD:01754 + TMT6plex-130 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 737#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 + + + + MassAvg + 357.26 + + + + MassMono + 357.257895 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01717 + MOD:01752 + MOD:01875 + PSI-MOD + + + MOD:01755 + TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 737#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 392.23 + + + + MassMono + 392.226261 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01719 + MOD:01752 + PSI-MOD + + + MOD:01756 + TMT6plex-130 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 + + + + MassAvg + 366.22 + + + + MassMono + 366.221844 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01717 + MOD:01752 + PSI-MOD + + + MOD:01757 + TMT6plex-130 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 316.19 + + + + MassMono + 316.194961 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01719 + MOD:01752 + PSI-MOD + + + MOD:01758 + TMT6plex-130 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 330.21 + + + + MassMono + 330.210611 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01719 + MOD:01752 + PSI-MOD + + + MOD:01759 + TMT6plex-130 reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + cysTMT6plex-130 reporter fragment + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 4 (13)C 4 H 16 (14)N 1 + + + + MassAvg + 130.14 + + + + MassMono + 130.141145 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01716 + + derives_from + MOD:017520 + + PSI-MOD + + + MOD:01760 + TMT6plex-131 reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 737 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + cysTMT6plex-131 reporter fragment + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01715 + + derives_from + MOD:018280 + + PSI-MOD + + + MOD:01761 + TMT6plex-131 reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 737#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01718 + MOD:01760 + PSI-MOD + + + MOD:01762 + TMT6plex-131 reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 737#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 + + + + MassAvg + 357.26 + + + + MassMono + 357.257895 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01717 + MOD:01760 + MOD:01875 + PSI-MOD + + + MOD:01763 + TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 737#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 392.23 + + + + MassMono + 392.226261 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01719 + MOD:01760 + PSI-MOD + + + MOD:01764 + TMT6plex-131 reporter+balance reagent N'-acylated histidine + + A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 + + + + MassAvg + 366.22 + + + + MassMono + 366.221844 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01717 + MOD:01760 + PSI-MOD + + + MOD:01765 + TMT6plex-131 reporter+balance reagent O3-acylated serine + + A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 316.19 + + + + MassMono + 316.194961 + + + + Origin + S + + + + Source + artifact + + + + TermSpec + none + + MOD:00916 + MOD:01719 + MOD:01760 + PSI-MOD + + + MOD:01766 + TMT6plex-131 reporter+balance reagent O3-acylated threonine + + A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + 229.16 + + + + DiffFormula + (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 + + + + DiffMono + 229.162932 + + + + Formula + (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 + + + + MassAvg + 330.21 + + + + MassMono + 330.210611 + + + + Origin + T + + + + Source + artifact + + + + TermSpec + none + + MOD:00917 + MOD:01719 + MOD:01760 + PSI-MOD + + + MOD:01767 + TMT6plex-131 reporter fragment + + The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue. + + 18688235 + PubMed + + + + 2,6-dimethyl-1-methylidenepiperidinium + PSI-MOD-alternate + + + Sixplex Tandem Mass Tag(TM) + UniMod-description + + + TMT6plex + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 4 (13)C 4 H 16 (15)N 1 + + + + MassAvg + 131.14 + + + + MassMono + 131.138180 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01716 + + derives_from + MOD:017600 + + PSI-MOD + + + MOD:01768 + O-palmitoleylated residue + + A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 236.40 + + + + DiffFormula + C 16 H 28 N 0 O 1 + + + + DiffMono + 236.214016 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00671 + MOD:01423 + PSI-MOD + + + MOD:01769 + O-palmitoleyl-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine. + + 6642431 + PubMed + + + 8413602 + PubMed + + + AA0079#var + RESID + + + 431#T + UniMod + + + PSI-MOD-slim + + (2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid + PSI-MOD-alternate + + + L-threonine cis-9-hexadecenoate ester + PSI-MOD-alternate + + + mod188 + OMSSA-label + + + O-palmitoleylated L-threonine + PSI-MOD-alternate + + + O3-palmitoleyl-threonine + PSI-MOD-alternate + + + Palmitoleyl + PSI-MS-label + + + palmitoleyl + UniMod-description + + + + DiffAvg + 236.40 + + + + DiffFormula + C 16 H 28 N 0 O 1 + + + + DiffMono + 236.214016 + + + + Formula + C 20 H 35 N 1 O 3 + + + + MassAvg + 337.50 + + + + MassMono + 337.261694 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01768 + PSI-MOD + + + MOD:01770 + O-palmitoyl-L-threonine amide + + A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide. + + 8413602 + PubMed + + + AA0079#var + RESID + + + AA0097#var + RESID + + + + (2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide + PSI-MOD-alternate + + + OPamThrN + PSI-MOD-label + + + + DiffAvg + 254.44 + + + + DiffFormula + C 16 H 32 N 1 O 1 + + + + DiffMono + 254.248390 + + + + Formula + C 20 H 39 N 2 O 3 + + + + MassAvg + 355.54 + + + + MassMono + 355.296068 + + + + Origin + T + + + + Source + natural + + + + TermSpec + C-term + + MOD:00917 + + has_functional_parent + MOD:000880 + + + has_functional_parent + MOD:001060 + + PSI-MOD + + + MOD:01771 + farnesyl reporter fragment + + The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues. + + 15609361 + PubMed + + + 18688235 + PubMed + + + PSI-MOD-slim + + (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium + PSI-MOD-alternate + + + Farn+ + PSI-MOD-label + + + farnesyl cation + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + C 15 H 25 + + + + MassAvg + 205.36 + + + + MassMono + 205.195077 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01520 + + derives_from + MOD:004370 + + PSI-MOD + + + MOD:01772 + palmityl reporter fragment + + The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues. + + 18688235 + PubMed + + + 8413602 + PubMed + + + PSI-MOD-slim + + palmityl cation + PSI-MS-label + + + Pam+ + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + C 16 H 31 O 1 + + + + MassAvg + 239.42 + + + + MassMono + 239.236942 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:01520 + + derives_from + MOD:004400 + + PSI-MOD + + + MOD:01773 + N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine + + Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment. + + 17205979 + PubMed + + + 18688235 + PubMed + + + PSI-MOD-slim + + dMe3N6Me3+Lys + PSI-MOD-label + + + + DiffAvg + -59.11 + + + + DiffFormula + C -3 H -9 N -1 O 0 + + + + DiffMono + -59.074048 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 10 N 1 O 1 + + + + MassAvg + 112.15 + + + + MassMono + 112.075690 + + + + Origin + MOD:00083 + + + + Source + artifact + + + + TermSpec + none + + MOD:00431 + MOD:00912 + + derives_from + MOD:000830 + + PSI-MOD + + + MOD:01774 + N6-octanoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine. + + 12591875 + PubMed + + + 2215217 + PubMed + + + AA0527 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-6-(octanoylamino)hexanoic acid + RESID-systematic + + + epsilon-octanoyllysine + RESID-alternate + + + N(zeta)-octanoyllysine + RESID-alternate + + + N6-(1-oxooctyl)-L-lysine + RESID-alternate + + + N6-octanoyl-L-lysine + RESID-name + + + + DiffAvg + 126.20 + + + + DiffFormula + C 8 H 14 N 0 O 1 + + + + DiffMono + 126.104465 + + + + Formula + C 14 H 26 N 2 O 2 + + + + MassAvg + 254.37 + + + + MassMono + 254.199428 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00666 + MOD:01875 + PSI-MOD + + + MOD:01775 + 5-glutamyl serotonin + + A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin. + + 11805836 + PubMed + + + 14697203 + PubMed + + + AA0528 + RESID + + + + (2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid + RESID-systematic + + + 5-glutamyl serotonin + RESID-name + + + N2-(gamma-glutamyl)-5-hydoxytryptamine + RESID-alternate + + + N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine + RESID-alternate + + + + DiffAvg + 159.19 + + + + DiffFormula + C 10 H 9 N 1 O 1 + + + + DiffMono + 159.068414 + + + + Formula + C 15 H 17 N 3 O 3 + + + + MassAvg + 287.32 + + + + MassMono + 287.126991 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + PSI-MOD + + + MOD:01776 + S-methylthiocarbonylaminoethylcysteine (Cys) + + A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine. + + 18688235 + PubMed + + + 20608637 + PubMed + + + This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate). + + (2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid + PSI-MOD-alternate + + + L-cysteine N-(methylthiocarbonyl)aziridine adduct + PSI-MOD-alternate + + + MTCTK + PSI-MOD-alternate + + + N6-methylthiocarbonyl-4-thialysine + PSI-MOD-alternate + + + S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + 117.17 + + + + DiffFormula + C 4 H 7 N 1 O 1 S 1 + + + + DiffMono + 117.024835 + + + + Formula + C 7 H 12 N 2 O 2 S 2 + + + + MassAvg + 220.31 + + + + MassMono + 220.034020 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:00905 + PSI-MOD + + + MOD:01777 + S-(glycyl)-L-cysteine (Gly) + + A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine. + + 22050 + ChEBI + + + 17726030 + PubMed + + + 18359941 + PubMed + + + 18771296 + PubMed + + + 18799456 + PubMed + + + 18842002 + PubMed + + + 3306404 + PubMed + + + AA0206 + RESID + + + This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG]. + + (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid + RESID-systematic + + + 1-(cystein-S-yl)-glycinate + RESID-alternate + + + glycine cysteine thioester + RESID-alternate + + + MOD_RES CysO-cysteine adduct + UniProt-feature + + + S-(2-amino-1-oxoethyl)cysteine + RESID-alternate + + + S-(glycyl)-L-cysteine + RESID-name + + + + DiffAvg + 103.14 + + + + DiffFormula + C 3 H 5 N 1 O 1 S 1 + + + + DiffMono + 103.009185 + + + + Formula + C 5 H 9 N 2 O 3 S 1 + + + + MassAvg + 177.20 + + + + MassMono + 177.033388 + + + + Origin + G + + + + Source + natural + + + + TermSpec + C-term + + MOD:00908 + PSI-MOD + + + MOD:01778 + N-(glycyl)-L-cysteine + + A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine. + + 18771296 + PubMed + + + 18799456 + PubMed + + + 18842002 + PubMed + + + AA0529 + RESID + + + + (2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid + RESID-systematic + + + MOD_RES CysO-cysteine adduct + UniProt-feature + + + N-(2-amino-1-oxoethyl)cysteine + RESID-alternate + + + N-(glycyl)-L-cysteine + RESID-name + + + + DiffAvg + 103.14 + + + + DiffFormula + C 3 H 5 N 1 O 1 S 1 + + + + DiffMono + 103.009185 + + + + Formula + C 5 H 9 N 2 O 3 S 1 + + + + MassAvg + 177.20 + + + + MassMono + 177.033388 + + + + Origin + G + + + + Source + hypothetical + + + + TermSpec + C-term + + MOD:00908 + PSI-MOD + + + MOD:01779 + N6-(L-lysyl)-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine. + + 18201202 + PubMed + + + 20729861 + PubMed + + + AA0530 + RESID + + + This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG]. + + (2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid + RESID-systematic + + + N6-(alpha-lysyl)-lysine + RESID-alternate + + + N6-(L-lysyl)-L-lysine + RESID-name + + + + DiffAvg + 128.18 + + + + DiffFormula + C 6 H 12 N 2 O 1 + + + + DiffMono + 128.094963 + + + + Formula + C 12 H 24 N 4 O 2 + + + + MassAvg + 256.35 + + + + MassMono + 256.189926 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01875 + PSI-MOD + + + MOD:01780 + N6-(beta-lysyl)-L-5-hydroxylysine + + A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine. + + 18201202 + PubMed + + + 20729861 + PubMed + + + AA0531 + RESID + + + + (2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid + RESID-systematic + + + 5-hydroxy-N6-(beta-lysyl)-L-lysine + RESID-name + + + 5-hydroxy-N6-[(3R)-beta-lysyl]lysine + RESID-alternate + + + EF-P lysine derivative + RESID-alternate + + + lysyl spermidine derivative [misidentification] + RESID-alternate + + + MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine + UniProt-feature + + + N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine + RESID-alternate + + + + DiffAvg + 144.17 + + + + DiffFormula + C 6 H 12 N 2 O 2 + + + + DiffMono + 144.089878 + + + + Formula + C 12 H 24 N 4 O 3 + + + + MassAvg + 272.35 + + + + MassMono + 272.184841 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00037 + MOD:01875 + PSI-MOD + + + MOD:01781 + N6-butanoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine. + + 17267393 + PubMed + + + 20715035 + PubMed + + + AA0532 + RESID + + + 1289 + UniMod + + + The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. + + (2S)-2-amino-6-(butanoylamino)hexanoic acid + RESID-systematic + + + (2S)-2-azanyl-6-(butanoylamino)hexanoic acid + RESID-alternate + + + 2-amino-6-butyrylaminocaproic acid + RESID-alternate + + + epsilon-butanoyl-L-lysine + RESID-alternate + + + epsilon-butyryl-L-lysine + RESID-alternate + + + N(zeta)-butanoyllysine + RESID-alternate + + + N6-(1-oxobutyl)-L-lysine + RESID-alternate + + + N6-butanoyl-L-lysine + RESID-name + + + N6-butyryllysine + RESID-alternate + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 N 0 O 1 + + + + DiffMono + 70.041865 + + + + Formula + C 10 H 18 N 2 O 2 + + + + MassAvg + 198.27 + + + + MassMono + 198.136828 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01875 + MOD:01997 + PSI-MOD + + + MOD:01782 + N-methyl-L-serine + + A protein modification that effectively converts an L-serine residue to N-methyl-L-serine. + + 20668449 + PubMed + + + AA0533 + RESID + + + PSI-MOD-slim + + (2S)-3-hydroxy-2-(methylamino)propanoic acid + RESID-systematic + + + MOD_RES N-methylserine + UniProt-feature + + + N-methyl-L-serine + RESID-name + + + N-methylserine + RESID-alternate + + + + DiffAvg + 14.03 + + + + DiffFormula + C 1 H 2 N 0 O 0 + + + + DiffMono + 14.015650 + + + + Formula + C 4 H 7 N 1 O 2 + + + + MassAvg + 101.10 + + + + MassMono + 101.047678 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:01680 + MOD:01800 + PSI-MOD + + + MOD:01783 + N,N-dimethyl-L-serine + + A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine. + + 20668449 + PubMed + + + AA0534 + RESID + + + + (2S)-2-(dimethylamino)propanoic acid + RESID-systematic + + + MOD_RES N,N-dimethylserine + UniProt-feature + + + N,N-dimethyl-L-serine + RESID-name + + + N,N-dimethylserine + RESID-alternate + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 5 H 10 N 1 O 2 + + + + MassAvg + 116.14 + + + + MassMono + 116.071154 + + + + Origin + S + + + + Source + natural + + + + TermSpec + N-term + + MOD:01686 + MOD:01800 + PSI-MOD + + + MOD:01784 + N,N,N-trimethyl-L-serine + + A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine. + + 20668449 + PubMed + + + 3979397 + PubMed + + + AA0535 + RESID + + + PSI-MOD-slim + + (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium + RESID-systematic + + + (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium + RESID-alternate + + + (2S)-2-trimethylammonio-3-hydroxypropanoic acid + RESID-alternate + + + MOD_RES N,N,N-trimethylserine + UniProt-feature + + + N,N,N-trimethyl-L-serine + RESID-name + + + N,N,N-trimethylserine cation + RESID-alternate + + + N,N,N-trimethylserinium + RESID-alternate + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 + + + + DiffMono + 43.054227 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 13 N 1 O 2 + + + + MassAvg + 131.17 + + + + MassMono + 131.094080 + + + + Origin + S + + + + Source + natural + + + + TermSpec + N-term + + MOD:01698 + MOD:01800 + PSI-MOD + + + MOD:01785 + O-(L-isoglutamyl)-L-threonine (active site intermediate) + + A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia. + + 8706862 + PubMed + + + AA0536#THR + RESID + + + This is not an ester cross-link of peptides [JSG]. + + (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid + RESID-alternate + + + 5-(threon-O3-yl)glutamate + RESID-alternate + + + O(beta)-(gamma-glutamyl)threonine + RESID-alternate + + + O-(L-isoglutamyl)-L-threonine + RESID-name + + + O3-(isoglutamyl)threonine + RESID-alternate + + + + DiffAvg + 129.12 + + + + DiffFormula + C 5 H 7 N 1 O 3 + + + + DiffMono + 129.042593 + + + + Formula + C 9 H 14 N 2 O 5 + + + + MassAvg + 230.22 + + + + MassMono + 230.090272 + + + + Origin + T + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00671 + MOD:01979 + PSI-MOD + + + MOD:01786 + 3'-nitro-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine. + + 44454 + ChEBI + + + 16944230 + PubMed + + + 5339594 + PubMed + + + AA0537 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid + RESID-systematic + + + 3'-nitro-L-tyrosine + RESID-name + + + 3-nitro-L-tyrosine + RESID-alternate + + + 3-nitrotyrosine + RESID-alternate + + + m-nitrotyrosine + RESID-alternate + + + meta-nitrotyrosine + RESID-alternate + + + MOD_RES 3'-Nitrotyrosine + UniProt-feature + + + + DiffAvg + 45.00 + + + + DiffFormula + C 0 H -1 N 1 O 2 + + + + DiffMono + 44.985078 + + + + Formula + C 9 H 8 N 2 O 4 + + + + MassAvg + 208.17 + + + + MassMono + 208.048407 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:01352 + PSI-MOD + + + MOD:01787 + 5'-(L-tyros-5'-yl)amino-L-tyrosine + + A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine. + + 18781570 + PubMed + + + AA0459 + RESID + + + Cross-link 2. + + (2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid) + RESID-systematic + + + 5'-(L-tyros-5'-yl)amino-L-tyrosine + RESID-name + + + 5'-[(tyros-5'-yl)amino]tyrosine + RESID-alternate + + + 5'-tyrosyl-5'-aminotyrosine + RESID-alternate + + + bis(LTQ) linkage + RESID-alternate + + + CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain) + UniProt-feature + + + + DiffAvg + 13.00 + + + + DiffFormula + C 0 H -1 N 1 O 0 + + + + DiffMono + 12.995249 + + + + Formula + C 18 H 17 N 3 O 4 + + + + MassAvg + 339.35 + + + + MassMono + 339.121906 + + + + Origin + Y, Y + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00692 + MOD:00919 + PSI-MOD + + + MOD:01788 + histidine immonium ion + + A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion. + + 17074506 + PubMed + + + 18688235 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + PSI-MOD-slim + + 2-(1H-imidazolyl)ethaniminium + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 8 N 3 O 0 + + + + MassAvg + 110.14 + + + + MassMono + 110.071274 + + + + Origin + H + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01527 + PSI-MOD + + + MOD:01789 + phenylalanine immonium ion + + A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion. + + 17074506 + PubMed + + + 18688235 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + PSI-MOD-slim + + 2-phenylethaniminium + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 8 H 10 N 1 O 0 + + + + MassAvg + 120.17 + + + + MassMono + 120.080776 + + + + Origin + F + + + + Source + artifact + + + + TermSpec + none + + MOD:00914 + MOD:01527 + PSI-MOD + + + MOD:01790 + tyrosine immonium ion + + A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion. + + 17074506 + PubMed + + + 18688235 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + PSI-MOD-slim + + 2-(4-hydroxyphenyl)ethaniminium + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 8 H 10 N 1 O 1 + + + + MassAvg + 136.17 + + + + MassMono + 136.075690 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01527 + PSI-MOD + + + MOD:01791 + phosphohistidine immonium ion + + A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion. + + 17690871 + PubMed + + + 18688235 + PubMed + + + 20847263 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + PSI-MOD-slim + + 2-(1H-imidazolyl)ethaniminium + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 9 N 3 O 3 P 1 + + + + MassAvg + 190.12 + + + + MassMono + 190.037604 + + + + Origin + MOD:00890 + + + + Source + artifact + + + + TermSpec + none + + MOD:00909 + MOD:01527 + + derives_from + MOD:008900 + + PSI-MOD + + + MOD:01792 + phosphotyrosine immonium ion + + A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion. + + 17690871 + PubMed + + + 18688235 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + PSI-MOD-slim + + 2-(4-phosphonoxyphenyl)ethaniminium + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 8 H 11 N 1 O 4 P 1 + + + + MassAvg + 216.15 + + + + MassMono + 216.042021 + + + + Origin + MOD:00048 + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01527 + + derives_from + MOD:000480 + + PSI-MOD + + + MOD:01793 + S-carboxamidomethyl-L-cysteine sulfoxide + + A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide. + + 11212008 + PubMed + + + 17689096 + PubMed + + + 18306178 + PubMed + + + 18688235 + PubMed + + + + CamCO + PSI-MOD-alternate + + + S-carbamoylmethyl-L-cysteine sulfoxide + PSI-MOD-alternate + + + + DiffAvg + 73.05 + + + + DiffFormula + C 2 H 3 N 1 O 2 + + + + DiffMono + 73.016378 + + + + Formula + C 5 H 8 N 2 O 3 S 1 + + + + MassAvg + 176.19 + + + + MassMono + 176.025563 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00708 + MOD:01854 + + derives_from + MOD:010600 + + PSI-MOD + + + MOD:01794 + 1x(13)C,3x(2)H labeled monomethylated residue + + A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue. + + 18688235 + PubMed + + + + Methyl:2H(3)13C(1) + PSI-MS-label + + + + DiffAvg + 18.04 + + + + DiffFormula + (13)C 1 (1)H -1 (2)H 3 + + + + DiffMono + 18.037835 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00842 + PSI-MOD + + + MOD:01795 + 1x(13)C,3x(2)H C(6)-labeled L-methionine + + A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine. + + 15782174 + PubMed + + + 18688235 + PubMed + + + + Methyl:2H(3)13C(1) + PSI-MS-label + + + + DiffAvg + 4.02 + + + + DiffFormula + (12)C -1 (13)C 1 (1)H -3 (2)H 3 + + + + DiffMono + 4.022185 + + + + Formula + (12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 1 S 1 + + + + MassAvg + 135.06 + + + + MassMono + 135.062670 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00913 + MOD:01794 + PSI-MOD + + + MOD:01796 + 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide + + A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide. + + 15782174 + PubMed + + + 18688235 + PubMed + + + + + DiffAvg + 20.02 + + + + DiffFormula + (12)C -1 (13)C 1 (1)H -3 (2)H 3 O 1 + + + + DiffMono + 20.017100 + + + + Formula + (12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 2 S 1 + + + + MassAvg + 151.06 + + + + MassMono + 151.057585 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00839 + MOD:00913 + MOD:01794 + PSI-MOD + + + MOD:01797 + 1'-phosphohistidine immonium ion + + A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion. + + 17690871 + PubMed + + + 18688235 + PubMed + + + 20847263 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + + 2-((1-phosphono-1H-imidazol-4-yl)ethaniminium + PSI-MOD-alternate + + + Ntau-phosphorylated L-histidine + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 9 N 3 O 3 P 1 + + + + MassAvg + 190.12 + + + + MassMono + 190.037604 + + + + Origin + MOD:00044 + + + + Source + artifact + + + + TermSpec + none + + MOD:01791 + + derives_from + MOD:000440 + + PSI-MOD + + + MOD:01798 + 3'-phosphohistidine immonium ion + + A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion. + + 18688235 + PubMed + + + This fragment corresponds to the first ion in an a+ series. + + 2-(1-phosphono-1H-imidazol-5-yl)ethaniminium + PSI-MOD-alternate + + + Npi-phosphorylated L-histidine + PSI-MOD-alternate + + + + DiffAvg + -27.00 + + + + DiffFormula + C -1 H 1 N 0 O -1 + + + + DiffMono + -26.987638 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 9 N 3 O 3 P 1 + + + + MassAvg + 190.12 + + + + MassMono + 190.037604 + + + + Origin + MOD:00045 + + + + Source + artifact + + + + TermSpec + none + + MOD:01791 + + derives_from + MOD:000450 + + PSI-MOD + + + MOD:01799 + methylated serine + + A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeSer + PSI-MOD-label + + + + Origin + S + + MOD:00427 + MOD:00916 + PSI-MOD + + + MOD:01800 + N-methylated serine + + A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + S + + + + Source + natural + + + + TermSpec + N-term + + MOD:01460 + MOD:01799 + PSI-MOD + + + MOD:01801 + protonated L-serine (L-serinium) residue + + A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine). + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + C 3 H 7 N 1 O 2 + + + + MassAvg + 89.09 + + + + MassMono + 89.047130 + + + + Origin + S + + + + Source + natural + + + + TermSpec + N-term + + MOD:00916 + MOD:01700 + PSI-MOD + + + MOD:01802 + N,N,N-trimethyl-L-serine (from L-serinium) + + A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine. + + 18688235 + PubMed + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ser process (MOD:00071) accounts for both protonation and trimethylation. + PSI-MOD-slim + + N2Me3Ala + PSI-MOD-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 + + + + DiffMono + 42.046402 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 13 N 1 O 2 + + + + MassAvg + 131.17 + + + + MassMono + 131.094080 + + + + Origin + MOD:01801 + + + + Source + natural + + + + TermSpec + N-term + + MOD:01687 + + derives_from + MOD:018010 + + PSI-MOD + + + MOD:01803 + O-methylated threonine + + A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester. + + 18688235 + PubMed + + + + OMeThr + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + MOD:00393 + MOD:01418 + PSI-MOD + + + MOD:01804 + glycosylphosphorylated residue + + A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond. + + 18688235 + PubMed + + + MOD:00764 + MOD:00861 + PSI-MOD + + + MOD:01805 + N-(L-isoaspartyl)-glycine (Asp) + + A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water. + + 21479 + ChEBI + + + 1826288 + PubMed + + + 18671394 + PubMed + + + AA0126 + RESID + + + Cross-link 2. + + (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid + RESID-systematic + + + 2-amino-N4-(carboxymethyl)-butanediamic acid + RESID-alternate + + + CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly) + UniProt-feature + + + CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp) + UniProt-feature + + + isoaspartyl glycine + RESID-alternate + + + N-(L-isoaspartyl)-glycine + RESID-name + + + N-beta-aspartylglycine + RESID-alternate + + + N4-(carboxymethyl)-asparagine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 7 N 2 O 3 + + + + MassAvg + 155.13 + + + + MassMono + 155.045667 + + + + Origin + D, G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00904 + MOD:00954 + MOD:01928 + PSI-MOD + + + MOD:01806 + N,N-dimethyl-L-leucine + + A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine. + + 19522542 + PubMed + + + AA0538 + RESID + + + + (2S)-2-(dimethylamino)-4-methylpentanoic acid + RESID-systematic + + + 2-(dimethylamino)-4-methylvaleric acid + RESID-alternate + + + 2-(dimethylazanyl)-4-methylpentanoic acid + RESID-alternate + + + MOD_RES N,N-dimethylleucine + UniProt-feature + + + N,N-dimethyl-L-leucine + RESID-name + + + N,N-dimethylleucine + RESID-alternate + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 16 N 1 O 1 + + + + MassAvg + 142.22 + + + + MassMono + 142.123189 + + + + Origin + L + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:01686 + MOD:01808 + PSI-MOD + + + MOD:01807 + N-formyl-L-glutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid. + + 18001127 + PubMed + + + AA0539 + RESID + + + + (2S)-2-(formylamino)pentanedioic acid + RESID-systematic + + + 2-(formylazanyl)pentanedioic acid + RESID-alternate + + + 2-formamidopentanedioic acid + RESID-alternate + + + 2-formylaminopentanedioic acid + RESID-alternate + + + N-formyl-L-glutamic acid + RESID-name + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 6 H 8 N 1 O 4 + + + + MassAvg + 158.13 + + + + MassMono + 158.045333 + + + + Origin + E + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00409 + MOD:00906 + PSI-MOD + + + MOD:01808 + N-methylated leucine + + A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + MeLeu + PSI-MOD-label + + + + Origin + L + + MOD:00662 + MOD:01460 + PSI-MOD + + + MOD:01809 + 5x(13)C,1x(15)N labeled residue + + A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue. + + 12771378 + PubMed + + + 268 + UniMod + + + + 13C(5) 15N(1) Silac label + UniMod-description + + + Label:13C(5)15N(1) + PSI-MS-label + + + + DiffAvg + 6.01 + + + + DiffFormula + (12)C -5 (13)C 5 (14)N -1 (15)N 1 + + + + DiffMono + 6.013809 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + MOD:00843 + PSI-MOD + + + MOD:01810 + 5x(13)C,1x(15)N labeled L-proline + + A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline. + + 12771378 + PubMed + + + 268#P + UniMod + + + + 13C(5) 15N(1) Silac label + UniMod-description + + + Label:13C(5)15N(1) + PSI-MS-label + + + + DiffAvg + 6.01 + + + + DiffFormula + (12)C -5 (13)C 5 (14)N -1 (15)N 1 + + + + DiffMono + 6.013809 + + + + Formula + (13)C 5 H 7 (15)N 1 O 1 + + + + MassAvg + 103.07 + + + + MassMono + 103.066573 + + + + Origin + P + + + + Source + artifact + + + + TermSpec + none + + MOD:00915 + MOD:01809 + PSI-MOD + + + MOD:01811 + 5x(13)C,1x(15)N labeled L-methionine + + A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine. + + 12771378 + PubMed + + + 268#M + UniMod + + + + 13C(5) 15N(1) Silac label + UniMod-description + + + Label:13C(5)15N(1) + PSI-MS-label + + + + DiffAvg + 6.01 + + + + DiffFormula + (12)C -5 (13)C 5 (14)N -1 (15)N 1 + + + + DiffMono + 6.013809 + + + + Formula + (13)C 5 H 9 (15)N 1 O 1 S 1 + + + + MassAvg + 137.05 + + + + MassMono + 137.054294 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00913 + MOD:01809 + PSI-MOD + + + MOD:01812 + 5x(13)C,1x(15)N labeled L-methionine sulfoxide + + A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide. + + 12771378 + PubMed + + + 268#M + UniMod + + + + 13C(5) 15N(1) Silac label + UniMod-description + + + Label:13C(5)15N(1) + PSI-MS-label + + + + DiffAvg + 6.01 + + + + DiffFormula + (12)C -5 (13)C 5 (14)N -1 (15)N 1 + + + + DiffMono + 6.013809 + + + + Formula + (13)C 5 H 9 (15)N 1 O 2 S 1 + + + + MassAvg + 153.05 + + + + MassMono + 153.049209 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00719 + MOD:01809 + PSI-MOD + + + MOD:01813 + morpholine-2-acetylated residue + + A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom. + + 10446193 + PubMed + + + 29 + UniMod + + + The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. + + N-Succinimidyl-2-morpholine acetate + UniMod-description + + + N-succinimidylmorpholine-2-acetate derivative + PSI-MOD-alternate + + + SMA + PSI-MS-label + + + + DiffAvg + 127.14 + + + + DiffFormula + C 6 H 9 N 1 O 2 + + + + DiffMono + 127.063329 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + MOD:00649 + MOD:00848 + PSI-MOD + + + MOD:01814 + L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid + + A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid. + + 18406324 + PubMed + + + 19678698 + PubMed + + + 893891 + PubMed + + + AA0540 + RESID + + + Cross-link 3. + + 6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid + RESID-systematic + + + 6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid + RESID-alternate + + + L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid + RESID-name + + + + DiffAvg + -54.07 + + + + DiffFormula + C 0 H -8 N -1 O -2 S 0 + + + + DiffMono + -54.055504 + + + + Formula + C 9 H 7 N 2 O 3 S 1 + + + + MassAvg + 223.23 + + + + MassMono + 223.017738 + + + + Origin + C, S, S + + + + Source + natural + + + + TermSpec + none + + MOD:01425 + PSI-MOD + + + MOD:01815 + L-glutamate thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid. + + 18406324 + PubMed + + + 19678698 + PubMed + + + 893891 + PubMed + + + AA0541 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + 2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys) + UniProt-feature + + + L-glutamate thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 8 H 8 N 2 O 3 S 1 + + + + MassAvg + 212.22 + + + + MassMono + 212.025563 + + + + Origin + C, E + + + + Source + natural + + + + TermSpec + none + + MOD:00906 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01816 + 2'-hydroxy-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan. + + 11714714 + PubMed + + + AA0542 + RESID + + + + (2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 2'-hydroxy-L-tryptophan + RESID-name + + + 2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid + RESID-alternate + + + 2-hydroxy-L-tryptophan + RESID-alternate + + + 2-hydroxy-tryptophan + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 11 H 10 N 2 O 2 + + + + MassAvg + 202.21 + + + + MassMono + 202.074228 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01622 + PSI-MOD + + + MOD:01817 + oxidation of tryptophan to 2'-oxo-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan. + + 9461080 + PubMed + + + AA0543 + RESID + + + + (2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid + RESID-systematic + + + 2'-oxo-L-tryptophan + RESID-name + + + 2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid + RESID-alternate + + + 2-oxo-L-tryptophan + RESID-alternate + + + 2-oxotryptophan + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 11 H 10 N 2 O 2 + + + + MassAvg + 202.21 + + + + MassMono + 202.074228 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:00679 + MOD:00918 + PSI-MOD + + + MOD:01818 + 1'-(L-tryptophan-3'-yl)-L-tryptophan + + A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan. + + 20600836 + PubMed + + + AA0544 + RESID + + + Cross-link 2. + + (2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid) + RESID-alternate + + + 1-(L-tryptophan-3-yl)-L-tryptophan + RESID-name + + + 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid + RESID-alternate + + + 3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole + RESID-systematic + + + 3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole + RESID-alternate + + + ditryptophan + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 22 H 18 N 4 O 2 + + + + MassAvg + 370.41 + + + + MassMono + 370.142976 + + + + Origin + W, W + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00918 + PSI-MOD + + + MOD:01819 + N6-succinyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine. + + 16582421 + PubMed + + + 21151122 + PubMed + + + AA0545 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid + RESID-systematic + + + 2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid + RESID-alternate + + + 4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate + RESID-alternate + + + MOD_RES N6-succinyllysine + UniProt-feature + + + N(epsilon)-(succinyl)lysine + RESID-alternate + + + N6-succinyl-L-lysine + RESID-name + + + succinyllysine + RESID-alternate + + + + DiffAvg + 100.07 + + + + DiffFormula + C 4 H 4 N 0 O 3 + + + + DiffMono + 100.016044 + + + + Formula + C 10 H 16 N 2 O 4 + + + + MassAvg + 228.25 + + + + MassMono + 228.111007 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01029 + MOD:01875 + PSI-MOD + + + MOD:01820 + isotope tagged sufhydryl reagent modified cysteine + + A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00905 + MOD:01426 + PSI-MOD + + + MOD:01821 + cysTMT6plex reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group. + + 985 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01428 + MOD:01429 + MOD:01820 + PSI-MOD + + + MOD:01822 + cysTMT6plex-zero reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group. + + 984 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysTMT + UniMod-interim + + + Native cysteine-reactive Tandem Mass Tag(TM) + UniMod-description + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 299.17 + + + + DiffFormula + (12)C 14 H 25 (14)N 3 O 2 S 1 + + + + DiffMono + 299.166748 + + + + Formula + (12)C 17 H 32 (14)N 4 O 4 S 2 + + + + MassAvg + 420.19 + + + + MassMono + 420.186498 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01823 + cysTMT6plex-126 reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 304.18 + + + + DiffFormula + (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 + + + + DiffMono + 304.177202 + + + + Formula + (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 + + + + MassAvg + 425.20 + + + + MassMono + 425.196952 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01824 + cysTMT6plex-127 reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 304.18 + + + + DiffFormula + (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 + + + + DiffMono + 304.177202 + + + + Formula + (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 + + + + MassAvg + 425.20 + + + + MassMono + 425.196952 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01825 + cysTMT6plex-128 reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 304.18 + + + + DiffFormula + (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 + + + + DiffMono + 304.177202 + + + + Formula + (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 + + + + MassAvg + 425.20 + + + + MassMono + 425.196952 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01826 + cysTMT6plex-129 reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 304.18 + + + + DiffFormula + (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 + + + + DiffMono + 304.177202 + + + + Formula + (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 + + + + MassAvg + 425.20 + + + + MassMono + 425.196952 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01827 + cysTMT6plex-130 reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 304.18 + + + + DiffFormula + (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 + + + + DiffMono + 304.177202 + + + + Formula + (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 + + + + MassAvg + 425.20 + + + + MassMono + 425.196952 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01828 + cysTMT6plex-131 reporter+balance reagent cysteine disulfide + + A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + cysteine-reactive Sixplex Tandem Mass Tag(TM) + UniMod-description + + + cysTMT6plex + UniMod-interim + + + S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl + PSI-MOD-alternate + + + + DiffAvg + 304.18 + + + + DiffFormula + (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 + + + + DiffMono + 304.177202 + + + + Formula + (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 + + + + MassAvg + 425.20 + + + + MassMono + 425.196952 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:01821 + PSI-MOD + + + MOD:01829 + S-carboxymethyl-L-cysteine sulfoxide + + A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide. + + 17689096 + PubMed + + + 18688235 + PubMed + + + + CmCO + PSI-MOD-alternate + + + + DiffAvg + 58.04 + + + + DiffFormula + C 2 H 2 N 0 O 2 S 0 + + + + DiffMono + 58.005479 + + + + Formula + C 5 H 7 N 1 O 3 S 1 + + + + MassAvg + 161.18 + + + + MassMono + 161.014664 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00399 + MOD:00708 + MOD:01854 + + derives_from + MOD:010610 + + PSI-MOD + + + MOD:01830 + S-carboxymethyl-L-cysteine sulfone + + A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone. + + 18688235 + PubMed + + + + CmCO2 + PSI-MOD-label + + + + DiffAvg + 74.03 + + + + DiffFormula + C 2 H 2 N 0 O 3 S 0 + + + + DiffMono + 74.000394 + + + + Formula + C 5 H 7 N 1 O 4 S 1 + + + + MassAvg + 177.17 + + + + MassMono + 177.009579 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00399 + MOD:00708 + MOD:01855 + + derives_from + MOD:010610 + + PSI-MOD + + + MOD:01831 + S-carboxamidomethyl-L-cysteine sulfone + + A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone. + + 18688235 + PubMed + + + + CamCO2 + PSI-MOD-label + + + S-carbamoylmethyl-L-cysteine sulfone + PSI-MOD-alternate + + + + DiffAvg + 89.05 + + + + DiffFormula + C 2 H 3 N 1 O 3 + + + + DiffMono + 89.011293 + + + + Formula + C 5 H 8 N 2 O 4 S 1 + + + + MassAvg + 192.19 + + + + MassMono + 192.020478 + + + + Origin + C + + + + Source + artifact + + + + TermSpec + none + + MOD:00397 + MOD:00708 + MOD:01855 + + derives_from + MOD:010600 + + PSI-MOD + + + MOD:01832 + 5x(13)C-labeled residue + + A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue. + + 12771378 + PubMed + + + 772 + UniMod + + + + 13C(5) Silac label + UniMod-description + + + Label:13C(5) + PSI-MS-label + + + + DiffAvg + 5.02 + + + + DiffFormula + (12)C -5 (13)C 5 + + + + DiffMono + 5.016774 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00842 + PSI-MOD + + + MOD:01833 + 5x(13)C-labeled L-methionine + + A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine. + + 18688235 + PubMed + + + + + DiffAvg + 5.02 + + + + DiffFormula + (12)C -5 (13)C 5 H 0 N 0 O 0 S 0 + + + + DiffMono + 5.016774 + + + + Formula + (13)C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 136.06 + + + + MassMono + 136.057259 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00913 + MOD:01832 + PSI-MOD + + + MOD:01834 + 5x(13)C-labeled L-methionine sulfoxide + + A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide. + + 18688235 + PubMed + + + + + DiffAvg + 21.01 + + + + DiffFormula + (12)C -5 (13)C 5 H 0 N 0 O 1 S 0 + + + + DiffMono + 21.011689 + + + + Formula + (13)C 5 H 9 N 1 O 2 S 1 + + + + MassAvg + 152.05 + + + + MassMono + 152.052174 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00719 + MOD:01832 + PSI-MOD + + + MOD:01835 + 5x(13)C-labeled L-methionine sulfone + + A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone. + + 18688235 + PubMed + + + + + DiffAvg + 37.01 + + + + DiffFormula + (12)C -5 (13)C 5 H 0 N 0 O 2 S 0 + + + + DiffMono + 37.006603 + + + + Formula + (13)C 5 H 9 N 1 O 3 S 1 + + + + MassAvg + 168.05 + + + + MassMono + 168.047088 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + none + + MOD:00256 + MOD:01832 + PSI-MOD + + + MOD:01836 + N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine + + A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine. + + 18688235 + PubMed + + + 20218600 + PubMed + + + 21271704 + PubMed + + + + (2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid + PSI-MOD-alternate + + + [(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine + PSI-MOD-alternate + + + + DiffAvg + 237.17 + + + + DiffFormula + C 10 H 7 N 1 O 6 + + + + DiffMono + 237.027337 + + + + Formula + C 16 H 19 N 3 O 7 + + + + MassAvg + 365.34 + + + + MassMono + 365.122300 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00848 + MOD:01875 + PSI-MOD + + + MOD:01837 + L-lanthionine (Cys-Cys) + + A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine. + + 21347 + ChEBI + + + 20805503 + PubMed + + + 6007887 + PubMed + + + AA0110#CYS2 + RESID + + + Cross-link 2. + + (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + RESID-systematic + + + (R)-S-(2-amino-2-carboxyethyl)-L-cysteine + RESID-alternate + + + (R,R)-2,6-diamino-4-thiaheptanedioic acid + RESID-alternate + + + (R,R)-3,3'-thiobis-(2-aminopropanoic acid) + RESID-alternate + + + (R,R)-bis(2-amino-2-carboxyethyl)sulfide + RESID-alternate + + + 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid + RESID-alternate + + + 3,3'-thiobis-L-alanine + RESID-alternate + + + L-lanthionine + RESID-name + + + + DiffAvg + -34.08 + + + + DiffFormula + C 0 H -2 N 0 O 0 S -1 + + + + DiffMono + -33.987721 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01839 + PSI-MOD + + + MOD:01838 + L-lysinoalanine (Lys) + + A protein modification that effectively converts an L-lysine residue to L-lysinoalanine. + + 19155267 + PubMed + + + 2544544 + PubMed + + + AA0123#LYS + RESID + + + This entry is for the modification of peptidyl lysine by a free serine. For the crosslink of peptidyl serine and peptidyl lysine see MOD:00132. + + (2R,9S)-lysinoalanine + RESID-alternate + + + (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid + RESID-systematic + + + alaninolysine + RESID-alternate + + + L-lysinoalanine + RESID-name + + + LAL + RESID-alternate + + + lysino-D-alanine + RESID-alternate + + + MOD_RES Lysino-D-alanine (Lys) + UniProt-feature + + + N-epsilon-(2-amino-2-carboxyethyl)-L-lysine + RESID-alternate + + + N6-(2-amino-2-carboxyethyl)-L-lysine + RESID-alternate + + + + DiffAvg + 87.08 + + + + DiffFormula + C 3 H 5 N 1 O 2 + + + + DiffMono + 87.032028 + + + + Formula + C 9 H 17 N 3 O 3 + + + + MassAvg + 215.25 + + + + MassMono + 215.126991 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01853 + PSI-MOD + + + MOD:01839 + L-lanthionine + + A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. + + 18688235 + PubMed + + + Cross-link 2. For the natural form of the lanthionine cross-link see MOD:00120 meso-lanthionine [JSG]. + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + C, X + + + + Source + artifact + + + + TermSpec + none + + MOD:00859 + MOD:01841 + PSI-MOD + + + MOD:01840 + L-allo-isoleucine + + A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine. + + 43433 + ChEBI + + + 20805503 + PubMed + + + AA0546 + RESID + + + + (2S,3R)-2-amino-3-methylpentanoic acid + RESID-systematic + + + 2-azanyl-3-methylpentanoic acid + RESID-alternate + + + 3-methyl-norvaline + RESID-alternate + + + allo-L-isoleucine + RESID-alternate + + + alpha-amino-beta-methylvaleric acid + RESID-alternate + + + L-allo-isoleucine + RESID-name + + + L-threo-isoleucine + RESID-alternate + + + MOD_RES L-allo-isoleucine + UniProt-feature + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 6 H 11 N 1 O 1 + + + + MassAvg + 113.16 + + + + MassMono + 113.084064 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00910 + PSI-MOD + + + MOD:01841 + lanthionine + + A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine. + + 18688235 + PubMed + + + Cross-link 2. [JSG]. + + 2,6-diamino-4-thiaheptanedioic acid + PSI-MOD-alternate + + + 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid + PSI-MOD-alternate + + + 3,3'-thiobis-(2-aminopropanoic acid) + PSI-MOD-alternate + + + 3,3'-thiobis-L-alanine + PSI-MOD-alternate + + + bis(2-amino-2-carboxyethyl)sulfanediyl + PSI-MOD-alternate + + + bis(2-amino-2-carboxyethyl)sulfide + PSI-MOD-alternate + + + S-(2-amino-2-carboxyethyl)-L-cysteine + PSI-MOD-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + C, X + + + + Source + artifact + + + + TermSpec + none + + MOD:01993 + PSI-MOD + + + MOD:01842 + S-(2-aminovinyl)-L-cysteine + + A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine. + + 20805503 + PubMed + + + AA0548 + RESID + + + Cross-link 2. + + (2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid + RESID-systematic + + + (R,Z)-S-(2-aminovinyl)cysteine + RESID-alternate + + + S-(2-aminovinyl)-L-cysteine + RESID-name + + + + DiffAvg + -80.10 + + + + DiffFormula + C -1 H -4 N 0 O -2 S -1 + + + + DiffMono + -79.993200 + + + + Formula + C 5 H 7 N 2 O 1 S 1 + + + + MassAvg + 143.18 + + + + MassMono + 143.027909 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + C-term + + MOD:01851 + PSI-MOD + + + MOD:01843 + 5'-chloro-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan. + + 18215770 + PubMed + + + AA0549 + RESID + + + + (2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid + RESID-systematic + + + 5'-chloro-L-tryptophan + RESID-name + + + MOD_RES 5'-chlorotryptophan + UniProt-feature + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 11 Cl 1 H 9 N 2 O 1 + + + + MassAvg + 220.66 + + + + MassMono + 220.040341 + + + + Origin + W + + + + Source + natural + + + + TermSpec + none + + MOD:01913 + PSI-MOD + + + MOD:01844 + 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid + + A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid. + + 15361623 + PubMed + + + 18729522 + PubMed + + + 20961038 + PubMed + + + 21254756 + PubMed + + + AA0550 + RESID + + + Cross-link 2. + + (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer] + RESID-alternate + + + 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid + RESID-name + + + 5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid + RESID-systematic + + + MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys) + UniProt-feature + + + + DiffAvg + -5.06 + + + + DiffFormula + C 0 H -7 N -1 O 1 S 0 + + + + DiffMono + -5.062935 + + + + Formula + C 9 H 10 N 1 O 3 S 1 + + + + MassAvg + 212.24 + + + + MassMono + 212.038139 + + + + Origin + C, L + + + + Source + natural + + + + TermSpec + N-term + + MOD:00905 + MOD:00911 + MOD:01856 + PSI-MOD + + + MOD:01845 + L-proline 5-hydroxyoxazole-4-carbothionic acid + + A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid. + + 15361623 + PubMed + + + 18729522 + PubMed + + + 20961038 + PubMed + + + 21254756 + PubMed + + + AA0551 + RESID + + + Cross-link 2. + + (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer] + RESID-alternate + + + 5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid + RESID-systematic + + + CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys) + UniProt-feature + + + L-proline 5-hydroxy-oxazole-4-carbothionic acid + RESID-name + + + + DiffAvg + -4.03 + + + + DiffFormula + C 0 H -4 N 0 O 0 S 0 + + + + DiffMono + -4.031300 + + + + Formula + C 8 H 8 N 2 O 2 S 1 + + + + MassAvg + 196.22 + + + + MassMono + 196.030649 + + + + Origin + C, P + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:00915 + MOD:01856 + PSI-MOD + + + MOD:01846 + methanobactin OB3b copper complex + + A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex. + + 15361623 + PubMed + + + 18729522 + PubMed + + + 20961038 + PubMed + + + 21254756 + PubMed + + + AA0552 + RESID + + + Cross-link 2. + + bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper + RESID-systematic + + + METAL copper [Cu-methanobactin OB3b complex] + UniProt-feature + + + methanobactin OB3b copper complex + RESID-name + + + + DiffAvg + 85.46 + + + + DiffFormula + C 0 Cu 1 H -10 N 0 O 2 S 0 + + + + DiffMono + 84.841176 + + + + Formula + C 6 Cu 1 H 0 N 2 O 4 S 2 + + + + MassAvg + 291.74 + + + + MassMono + 290.859546 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + N-term + + MOD:00742 + MOD:00905 + PSI-MOD + + + MOD:01847 + L-cysteine sulfinyl phosphate + + A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate. + + 16565085 + PubMed + + + AA0557 + RESID + + + + (2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid + RESID-systematic + + + cysteine sulfinic phosphoryl ester + RESID-alternate + + + L-cysteine sulfinyl phosphate + RESID-name + + + + DiffAvg + 111.98 + + + + DiffFormula + C 0 H 1 N 0 O 5 P 1 S 0 + + + + DiffMono + 111.956160 + + + + Formula + C 3 H 6 N 1 O 6 P 1 S 1 + + + + MassAvg + 215.12 + + + + MassMono + 214.965345 + + + + Origin + C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00708 + MOD:00861 + PSI-MOD + + + MOD:01848 + S-(spermidinoglutathion-S-yl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine. + + 16613 + ChEBI + + + 20530482 + PubMed + + + AA0558 + RESID + + + + (2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid + RESID-systematic + + + cysteine glutathionylspermidine disulfide + RESID-alternate + + + L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide + RESID-alternate + + + S-(spermidinoglutathion-S-yl)-L-cysteine + RESID-name + + + + DiffAvg + 432.54 + + + + DiffFormula + C 17 H 32 N 6 O 5 S 1 + + + + DiffMono + 432.215489 + + + + Formula + C 20 H 37 N 7 O 6 S 2 + + + + MassAvg + 535.68 + + + + MassMono + 535.224674 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01862 + PSI-MOD + + + MOD:01849 + S-(2-aminovinyl)-D-cysteine (Cys-Cys) + + A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine. + + 20805503 + PubMed + + + AA0204#CYS2 + RESID + + + Cross-link 2. + + (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid + RESID-systematic + + + (S,Z)-S-(2-aminovinyl)cysteine + RESID-alternate + + + CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys) + UniProt-feature + + + S-(2-aminovinyl)-D-cysteine + RESID-name + + + + DiffAvg + -80.10 + + + + DiffFormula + C -1 H -4 N 0 O -2 S -1 + + + + DiffMono + -79.993200 + + + + Formula + C 5 H 7 N 2 O 1 S 1 + + + + MassAvg + 143.18 + + + + MassMono + 143.027909 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + C-term + + MOD:01850 + PSI-MOD + + + MOD:01850 + S-(2-aminovinyl)-D-cysteine + + A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. + + AA0204 + RESID + + + Cross-link 2. + + (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid + RESID-systematic + + + (S,Z)-S-(2-aminovinyl)cysteine + RESID-alternate + + + S-(2-aminovinyl)-D-cysteine + RESID-name + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 7 N 2 O 1 S 1 + + + + MassAvg + 143.18 + + + + MassMono + 143.027909 + + + + Origin + C, X + + + + Source + natural + + + + TermSpec + C-term + + MOD:01851 + PSI-MOD + + + MOD:01851 + S-(2-aminovinyl)-cysteine + + A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine. + + 18688235 + PubMed + + + Cross-link 2. + + 2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 5 H 7 N 2 O 1 S 1 + + + + MassAvg + 143.18 + + + + MassMono + 143.027909 + + + + Origin + C, X + + + + Source + natural + + + + TermSpec + C-term + + MOD:00687 + MOD:00859 + PSI-MOD + + + MOD:01852 + L-lysinoalanine (Lys-Cys) + + A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. + + 0 + DeltaMass + + + Cross-link 2. This entry is for a crosslink of peptidyl cysteine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34 with no citation or formula. [JSG] + + Lysinoalanine (from Cysteine) + DeltaMass-label + + + + DiffAvg + -34.08 + + + + DiffFormula + C 0 H -2 N 0 O 0 S -1 + + + + DiffMono + -33.987721 + + + + Formula + C 9 H 15 N 3 O 2 + + + + MassAvg + 197.24 + + + + MassMono + 197.116427 + + + + Origin + C, K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00692 + MOD:00905 + MOD:01853 + PSI-MOD + + + MOD:01853 + L-lysinoalanine + + A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine. + + 18688235 + PubMed + + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:00912 + PSI-MOD + + + MOD:01854 + sulfur monooxygenated residue + + A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00680 + PSI-MOD + + + MOD:01855 + sulfur dioxygenated residue + + A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:00680 + PSI-MOD + + + MOD:01856 + oxazole/oxazoline ring crosslinked residues (Cys) + + A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. + + 18688235 + PubMed + + + MOD:01419 + PSI-MOD + + + MOD:01857 + 2-(L-cystein-S-yl)-methionine + + A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine. + + 20805502 + PubMed + + + AA0559 + RESID + + + Cross-link 2. The chirality around the methionine alpha-carbon has not been determined. + + (2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-(L-cystein-S-yl)-methionine + RESID-name + + + CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met) + UniProt-feature + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 8 H 12 N 2 O 2 S 2 + + + + MassAvg + 232.32 + + + + MassMono + 232.034020 + + + + Origin + C, M + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:00913 + MOD:01992 + PSI-MOD + + + MOD:01858 + S-(N-acetylamino)glucosyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine. + + 61631 + ChEBI + + + 21251913 + PubMed + + + 21395300 + PubMed + + + AA0560 + RESID + + + + (2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid + RESID-systematic + + + CARBOHYD S-linked (GlcNAc) + UniProt-feature + + + S-(N-acetylamino)glucosyl-L-cysteine + RESID-name + + + S-[(N-acetylamino)glycosyl]cysteine + RESID-alternate + + + S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine + RESID-alternate + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 S 0 + + + + DiffMono + 203.079373 + + + + Formula + C 11 H 18 N 2 O 6 S 1 + + + + MassAvg + 306.33 + + + + MassMono + 306.088557 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00426 + MOD:00448 + MOD:00905 + PSI-MOD + + + MOD:01859 + 4-amino-3-isothiazolidinone-L-phenylalanine + + A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine. + + 17502599 + PubMed + + + AA0562 + RESID + + + Cross-link 2. + + (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid + RESID-systematic + + + 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid + RESID-alternate + + + 4-amino-3-isothiazolidinone-L-phenylalanine + RESID-alternate + + + CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe) + UniProt-feature + + + cysteinyl phenylalanine sulfenamide + RESID-alternate + + + N,N-(L-cysteine-1,S-diyl)-L-phenylalanine + RESID-name + + + phenylalanine-cysteine sulfenyl amide cross-link + RESID-alternate + + + phenylalanine-cysteine sulphenyl amide cross-link + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 12 H 12 N 2 O 2 S 1 + + + + MassAvg + 248.30 + + + + MassMono + 248.061949 + + + + Origin + C, F + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00905 + MOD:00914 + MOD:01861 + PSI-MOD + + + MOD:01860 + L-cysteine bacillithiol disulfide + + A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide. + + 61338 + ChEBI + + + 19578333 + PubMed + + + AA0563 + RESID + + + + (2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid + RESID-systematic + + + BSH + RESID-alternate + + + L-cysteine bacillithiol disulfide + RESID-name + + + MOD_RES S-bacillithiol cysteine disulfide + UniProt-feature + + + + DiffAvg + 396.37 + + + + DiffFormula + C 13 H 20 N 2 O 10 S 1 + + + + DiffMono + 396.083866 + + + + Formula + C 16 H 25 N 3 O 11 S 2 + + + + MassAvg + 499.51 + + + + MassMono + 499.093051 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01862 + PSI-MOD + + + MOD:01861 + isothiazolidinone ring crosslinked residues + + A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring. + + 18688235 + PubMed + + + The isothiazolidinone ring is usually formed by the reaction of a cysteine sulfenic acid with the amido nitrogen releasing water. + MOD:00033 + PSI-MOD + + + MOD:01862 + disulfide conjugated residue + + A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains. + + 18688235 + PubMed + + + PSI-MOD-slim + + S-thiolation + PSI-MOD-alternate + + + + Origin + C + + + + TermSpec + none + + MOD:01886 + PSI-MOD + + + MOD:01863 + mTRAQ reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups. + + 18688235 + PubMed + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01426 + MOD:01705 + PSI-MOD + + + MOD:01864 + mTRAQ light reporter+balance reagent acylated residue + + A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group. + + 888 + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + mTRAQ heavy + UniMod-description + + + + DiffAvg + 140.09 + + + + DiffFormula + (12)C 7 H 12 (14)N 2 (16)O 1 + + + + DiffMono + 140.094963 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01863 + MOD:01868 + PSI-MOD + + + MOD:01865 + mTRAQ light reporter+balance reagent acylated N-terminal + + A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group. + + 888#N-term + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + mTRAQ light + UniMod-description + + + mTRAQ light on nterm + OMSSA-label + + + + DiffAvg + 140.09 + + + + DiffFormula + (12)C 7 H 12 (14)N 2 (16)O 1 + + + + DiffMono + 140.094963 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01864 + PSI-MOD + + + MOD:01866 + mTRAQ light reporter+balance reagent N6-acylated lysine + + A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group. + + 888#K + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + PSI-MOD-slim + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + mTRAQ light + UniMod-description + + + mTRAQ light on K + OMSSA-label + + + + DiffAvg + 140.09 + + + + DiffFormula + (12)C 7 H 12 (14)N 2 (16)O 1 + + + + DiffMono + 140.094963 + + + + Formula + (12)C 13 H 24 N 2 (14)N 2 O 1 (16)O 1 + + + + MassAvg + 268.19 + + + + MassMono + 268.189926 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:01864 + MOD:01875 + PSI-MOD + + + MOD:01867 + mTRAQ light reporter+balance reagent O4'-acylated tyrosine + + A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group. + + 888#Y + UniMod + + + The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. + + (4-methylpiperazin-1-yl)acetyl + PSI-MOD-alternate + + + Applied Biosystems mTRAQ(TM) reagent + UniMod-alternate + + + mTRAQ light + UniMod-description + + + mTRAQ light on Y + OMSSA-label + + + + DiffAvg + 140.09 + + + + DiffFormula + (12)C 7 H 12 (14)N 2 (16)O 1 + + + + DiffMono + 140.094963 + + + + Formula + (12)C 16 H 21 (14)N 3 O 2 (16)O 1 + + + + MassAvg + 303.16 + + + + MassMono + 303.158292 + + + + Origin + Y + + + + Source + artifact + + + + TermSpec + none + + MOD:00919 + MOD:01864 + PSI-MOD + + + MOD:01868 + modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da + + Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01515 + PSI-MOD + + + MOD:01869 + mTRAQ light reporter fragment + + The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + + 4-methyl-1-methylidenepiperazin-1-ium + PSI-MOD-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + FormalCharge + 1+ + + + + Formula + (12)C 6 H 13 (14)N 2 + + + + MassAvg + 113.11 + + + + MassMono + 113.107325 + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:01870 + + derives_from + MOD:018640 + + PSI-MOD + + + MOD:01870 + mTRAQ reporter fragment + + A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue. + + 18688235 + PubMed + + + PSI-MOD-slim + MOD:01520 + PSI-MOD + + + MOD:01871 + cyclized N-terminal S-carboxamidomethyl-L-cysteine + + A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia. + + 336 + DeltaMass + + + 12643538 + PubMed + + + 26 + UniMod + + + PSI-MOD-slim + + (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid + DeltaMass-label + + + 5-oxothiomorpholine-3-carboxylic acid + PSI-MOD-alternate + + + Otc + DeltaMass-label + + + Pyro-carbamidomethyl + UniMod-interim + + + S-carbamoylmethylcysteine cyclization (N-terminus) + UniMod-description + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 S 0 + + + + DiffMono + -17.026549 + + + + Formula + C 5 H 6 N 1 O 2 S 1 + + + + MassAvg + 144.17 + + + + MassMono + 144.011924 + + + + Origin + MOD:01060 + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00397 + MOD:00419 + + derives_from + MOD:010600 + + PSI-MOD + + + MOD:01872 + cyclized N-terminal S-carboxymethyl-L-cysteine + + A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water. + + 12643538 + PubMed + + + 26 + UniMod + + + Contrary to the impression given in UniMod entry 26, the cyclization of N-terminal S-carboxymethyl-L-cysteine is not reported in PubMed:1263538. The cyclization would be expected to proceed under strongly acidic conditions [JSG]. + PSI-MOD-slim + + (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid + DeltaMass-label + + + 5-oxothiomorpholine-3-carboxylic acid + PSI-MOD-alternate + + + Otc + DeltaMass-label + + + Pyro-carbamidomethyl + UniMod-interim + + + S-carbamoylmethylcysteine cyclization (N-terminus) + UniMod-description + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 5 H 6 N 1 O 2 S 1 + + + + MassAvg + 144.17 + + + + MassMono + 144.011924 + + + + Origin + MOD:01061 + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00399 + MOD:00419 + + derives_from + MOD:010610 + + PSI-MOD + + + MOD:01873 + N-carboxy-L-alanine + + A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine. + + 18688235 + PubMed + + + 4593770 + PubMed + + + 4647257 + PubMed + + + 8312270 + PubMed + + + This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. + + (S)-2-carboxyamino-propanoic acid + PSI-MOD-alternate + + + 2-carbamic-propanoic acid + PSI-MOD-alternate + + + N-carboxymethionine + PSI-MOD-alternate + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 + + + + DiffMono + 43.989829 + + + + Formula + C 4 H 6 N 1 O 3 + + + + MassAvg + 116.10 + + + + MassMono + 116.034768 + + + + Origin + A + + + + Source + natural + + + + TermSpec + N-term + + MOD:00901 + MOD:01152 + PSI-MOD + + + MOD:01874 + N-carboxy-L-valine + + A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine. + + 18688235 + PubMed + + + 4593770 + PubMed + + + 4647257 + PubMed + + + 8312270 + PubMed + + + This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. + + (S)-2-carboxyamino-propanoic acid + PSI-MOD-alternate + + + 2-carbamic-propanoic acid + PSI-MOD-alternate + + + N-carboxymethionine + PSI-MOD-alternate + + + + DiffAvg + 44.01 + + + + DiffFormula + C 1 H 0 N 0 O 2 + + + + DiffMono + 43.989829 + + + + Formula + C 6 H 10 N 1 O 3 + + + + MassAvg + 144.15 + + + + MassMono + 144.066068 + + + + Origin + V + + + + Source + natural + + + + TermSpec + N-term + + MOD:00920 + MOD:01152 + PSI-MOD + + + MOD:01875 + N6-acylated L-lysine + + A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + N6AcylLys + PSI-MOD-label + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00670 + MOD:00912 + PSI-MOD + + + MOD:01876 + 4x(1)H,4x(12)C-labeled alpha-amino succinylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(12)C labeled succinyl group. + + 11857757 + PubMed + + + 12175151 + PubMed + + + 12716131 + PubMed + + + 64 + UniMod + + + + Succinic anhydride labeling reagent, light form (+4amu, 4H2) site N-term + UniMod-description + + + Succinyl + PSI-MS-label + + + + DiffAvg + 100.02 + + + + DiffFormula + (12)C 4 (1)H 4 O 3 + + + + DiffMono + 100.016044 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00457 + MOD:01426 + PSI-MOD + + + MOD:01877 + 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid + + A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid. + + 20961038 + PubMed + + + AA0553 + RESID + + + Cross-link 2. + + (4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole + RESID-alternate + + + 2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid + RESID-systematic + + + 2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer] + RESID-alternate + + + 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid + RESID-name + + + CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys) + UniProt-feature + + + + DiffAvg + -6.05 + + + + DiffFormula + C 0 H -6 N 0 O 0 S 0 + + + + DiffMono + -6.046950 + + + + Formula + C 9 H 12 N 5 O 2 S 1 + + + + MassAvg + 254.29 + + + + MassMono + 254.071171 + + + + Origin + C, R + + + + Source + natural + + + + TermSpec + N-term + + MOD:00902 + MOD:00905 + MOD:01883 + PSI-MOD + + + MOD:01878 + L-threonine 5-hydroxyoxazole-4-carbonthionic acid + + A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid. + + 20961038 + PubMed + + + AA0554 + RESID + + + Cross-link 2. + + (4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer] + RESID-alternate + + + 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid + RESID-systematic + + + CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys) + UniProt-feature + + + L-threonine 5-hydroxy-oxazole-4-carbonthionic acid + RESID-name + + + + DiffAvg + -4.03 + + + + DiffFormula + C 0 H -4 N 0 O 0 S 0 + + + + DiffMono + -4.031300 + + + + Formula + C 7 H 8 N 2 O 3 S 1 + + + + MassAvg + 200.21 + + + + MassMono + 200.025563 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:00917 + MOD:01856 + PSI-MOD + + + MOD:01879 + methanobactin SB2 copper complex + + A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex. + + 20961038 + PubMed + + + AA0555 + RESID + + + Cross-link 2. + + [5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper + RESID-systematic + + + METAL copper [Cu-methanobactin SB2 complex] + UniProt-feature + + + methanobactin SB2 copper complex + RESID-name + + + + DiffAvg + 84.48 + + + + DiffFormula + C 0 Cu 1 H -9 N 1 O 1 S 0 + + + + DiffMono + 83.857161 + + + + Formula + C 6 Cu 1 H 1 N 3 O 3 S 2 + + + + MassAvg + 290.76 + + + + MassMono + 289.875530 + + + + Origin + C, C, R, T + + + + Source + natural + + + + TermSpec + N-term + + MOD:00742 + MOD:00905 + PSI-MOD + + + MOD:01880 + L-deoxyhypusine + + modification from RESID + + 50038 + ChEBI + + + 16452303 + PubMed + + + AA0564 + RESID + + + + (2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid + RESID-systematic + + + deoxyhypusine + RESID-alternate + + + L-deoxyhypusine + RESID-name + + + N6-(4-aminobutyl)lysine + RESID-alternate + + + + DiffAvg + 71.12 + + + + DiffFormula + C 4 H 9 N 1 O 0 + + + + DiffMono + 71.073499 + + + + Formula + C 10 H 21 N 3 O 1 + + + + MassAvg + 199.30 + + + + MassMono + 199.168462 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01884 + PSI-MOD + + + MOD:01881 + 3-(L-phenylalan-2'-yl)-L-valine + + A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine. + + 21596985 + PubMed + + + AA0565 + RESID + + + Cross-link 2. + + (2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid + RESID-systematic + + + 3-(L-phenylalan-2'-yl)-L-valine + RESID-name + + + symerythrin valine-phenylalanine cross-link + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + C 14 H 16 N 2 O 2 + + + + MassAvg + 244.29 + + + + MassMono + 244.121178 + + + + Origin + F, V + + + + Source + natural + + + + TermSpec + none + + MOD:00692 + MOD:00914 + MOD:00920 + PSI-MOD + + + MOD:01882 + 5-imidazolinone ring crosslinked residues (Gly) + + A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring. + + 18688235 + PubMed + + + MOD:00691 + PSI-MOD + + + MOD:01883 + 5-imidazolinone ring crosslinked residues (Cys) + + A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring. + + 18688235 + PubMed + + + MOD:00691 + PSI-MOD + + + MOD:01884 + 4-aminobutylated residue + + A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + TermSpec + none + + MOD:00001 + PSI-MOD + + + MOD:01885 + biotinylated residue + + A protein modification that effectively replaces a hydrogen atom with a biotinyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + 5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl + PSI-MOD-alternate + + + Biotinylation + PSI-MOD-alternate + + + BtnRes + PSI-MOD-label + + + + DiffAvg + 226.29 + + + + DiffFormula + C 10 H 14 N 2 O 2 S 1 + + + + DiffMono + 226.077599 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:01886 + thiolated residue + + A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group. + + 18688235 + PubMed + + + PSI-MOD-slim + + + Origin + X + + + + TermSpec + none + + MOD:00860 + PSI-MOD + + + MOD:01887 + Uniblue A derivatized lysine + + A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct. + + 18688235 + PubMed + + + PSI-MOD-slim + + 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate + PSI-MOD-alternate + + + 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate + PSI-MOD-alternate + + + N6UniblueALys + PSI-MOD-label + + + Uniblue A + PSI-MOD-alternate + + + + DiffAvg + 484.50 + + + + DiffFormula + C 22 H 16 N 2 O 7 S 2 + + + + DiffMono + 484.039893 + + + + Formula + C 28 H 28 N 4 O 8 S 2 + + + + MassAvg + 612.67 + + + + MassMono + 612.134856 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00912 + MOD:01659 + PSI-MOD + + + MOD:01888 + didehydrogenated residue + + A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue. + + 401 + UniMod + + + PSI-MOD-slim + + 2dHRes + PSI-MOD-label + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 + + + + DiffMono + -2.015650 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00683 + PSI-MOD + + + MOD:01889 + S-(2-succinyl)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid. + + 16624247 + PubMed + + + 18448829 + PubMed + + + 20677745 + PubMed + + + AA0561 + RESID + + + 957 + UniMod + + + + (2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid + RESID-systematic + + + (2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid + RESID-alternate + + + 2-((2-amino-2-carboxyethyl)thio)butanedioic acid + RESID-alternate + + + 2-amino-3-(1,2-dicarboxyethylthio)propanoic acid + RESID-alternate + + + S-(1,2-dicarboxyethyl)cysteine + RESID-alternate + + + S-(2-succinyl)-L-cysteine + RESID-name + + + S-(2-succinyl)cysteine + RESID-alternate + + + S-[(2R)-2-succinyl]-L-cysteine + RESID-alternate + + + + DiffAvg + 116.07 + + + + DiffFormula + C 4 H 4 N 0 O 4 S 0 + + + + DiffMono + 116.010959 + + + + Formula + C 7 H 9 N 1 O 5 S 1 + + + + MassAvg + 219.21 + + + + MassMono + 219.020143 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00001 + MOD:00905 + PSI-MOD + + + MOD:01890 + N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) + + A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. + + 19622680 + PubMed + + + AA0566#FMET + RESID + + + Cross-link 2. + + (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + N-[(L-histidin-1'-yl)methyl]-L-methionine + RESID-name + + + + DiffAvg + -16.00 + + + + DiffFormula + C 0 H 0 N 0 O -1 S 0 + + + + DiffMono + -15.994915 + + + + Formula + C 12 H 17 N 4 O 2 S 1 + + + + MassAvg + 281.35 + + + + MassMono + 281.107222 + + + + Origin + H, MOD:00030 + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00909 + MOD:01450 + PSI-MOD + + + MOD:01891 + N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) + + A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. + + 19622680 + PubMed + + + AA0566#MET + RESID + + + Cross-link 2. + + (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + N-[(L-histidin-1'-yl)methyl]-L-methionine + RESID-name + + + + DiffAvg + 12.01 + + + + DiffFormula + C 1 H 0 N 0 O 0 S 0 + + + + DiffMono + 12.000000 + + + + Formula + C 12 H 17 N 4 O 2 S 1 + + + + MassAvg + 281.35 + + + + MassMono + 281.107222 + + + + Origin + H, M + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00909 + MOD:00913 + PSI-MOD + + + MOD:01892 + N6-crotonyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine. + + 21925322 + PubMed + + + AA0567 + RESID + + + + (2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid + RESID-alternate + + + (2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid + RESID-systematic + + + (2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid + RESID-alternate + + + MOD_RES N6-crotonyl-L-lysine + UniProt-feature + + + N(epsilon)-crotonyllysine + RESID-alternate + + + N6-(E)-crotonyllysine + RESID-alternate + + + N6-[(2E)-2-butenoyl]-L-lysine + RESID-alternate + + + N6-crotonyl-L-lysine + RESID-name + + + N6-crotonyllysine + RESID-alternate + + + N6-trans-crotonyllysine + RESID-alternate + + + + DiffAvg + 68.07 + + + + DiffFormula + C 4 H 4 N 0 O 1 + + + + DiffMono + 68.026215 + + + + Formula + C 10 H 16 N 2 O 2 + + + + MassAvg + 196.25 + + + + MassMono + 196.121178 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01875 + PSI-MOD + + + MOD:01893 + N6-malonyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine. + + 21908771 + PubMed + + + 8349414 + PubMed + + + AA0568 + RESID + + + + (2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid + RESID-systematic + + + 2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid + RESID-alternate + + + malonyllysine + RESID-alternate + + + MOD_RES N6-malonyllysine + UniProt-feature + + + N(epsilon)-(malonyl)lysine + RESID-alternate + + + N6-(carboxyacetyl)lysine + RESID-alternate + + + N6-malonyl-L-lysine + RESID-name + + + N6-malonyllysine + RESID-alternate + + + + DiffAvg + 86.05 + + + + DiffFormula + C 3 H 2 N 0 O 3 + + + + DiffMono + 86.000394 + + + + Formula + C 9 H 14 N 2 O 4 + + + + MassAvg + 214.22 + + + + MassMono + 214.095357 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01875 + PSI-MOD + + + MOD:01894 + propanoylated residue + + A protein modification that effectively replaces a hydrogen atom with an propanoyl group. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 58 + UniMod + + + + Propionate labeling reagent light form (N-term & K) + UniMod-description + + + Propionyl + PSI-MS-label + + + + DiffAvg + 56.06 + + + + DiffFormula + C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:01895 + alpha-amino 3x(12)C-labeled propanoylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group. + + 11857757 + PubMed + + + 11999733 + PubMed + + + 12175151 + PubMed + + + 58#N-term + UniMod + + + + Propionate labeling reagent light form (N-term & K) + UniMod-description + + + Propionyl + PSI-MS-label + + + + DiffAvg + 56.03 + + + + DiffFormula + (12)C 3 H 4 O 1 + + + + DiffMono + 56.026215 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00451 + PSI-MOD + + + MOD:01896 + trifluoroacetic acid adduct + + A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue. + + 18688235 + PubMed + + + Trifluoroacetic acid has been observed to form adducts in both negative and positive mode analysis (Mark Collins, private communication) [JSG]. + + TFA + DeltaMass-label + + + + DiffAvg + 114.02 + + + + DiffFormula + C 2 F 3 H 1 O 2 + + + + DiffMono + 113.992864 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00498 + MOD:00848 + PSI-MOD + + + MOD:01897 + 5-hydroxy-3-methyl-L-proline (Ile) + + A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline. + + 21788474 + PubMed + + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0473 + RESID + + + + (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid + RESID-systematic + + + 5-hydroxy-3-methyl-L-proline + RESID-name + + + 5-hydroxy-3-methylproline + RESID-alternate + + + 5Hy3MePro(Ile) + PSI-MOD-label + + + beta-methyl-delta-hydroxyproline + RESID-alternate + + + MOD_RES 5-hydroxy-3-methylproline (Ile) + UniProt-feature + + + + DiffAvg + 13.98 + + + + DiffFormula + C 0 H -2 N 0 O 1 + + + + DiffMono + 13.979265 + + + + Formula + C 6 H 9 N 1 O 2 + + + + MassAvg + 127.14 + + + + MassMono + 127.063329 + + + + Origin + I + + + + Source + natural + + + + TermSpec + none + + MOD:00601 + MOD:00679 + MOD:00910 + MOD:01888 + MOD:01905 + PSI-MOD + + + MOD:01898 + N2,N2-dimethyl-L-arginine + + modification from RESID + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0569 + RESID + + + + (2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid + RESID-systematic + + + (2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer] + RESID-alternate + + + MOD_RES N2,N2-dimethylarginine + UniProt-feature + + + N(alpha),N(alpha)-dimethylarginine + RESID-alternate + + + N2,N2-dimethyl-L-arginine + RESID-name + + + N2,N2-dimethylarginine + RESID-alternate + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 8 H 17 N 4 O 1 + + + + MassAvg + 185.25 + + + + MassMono + 185.140236 + + + + Origin + R + + + + Source + natural + + + + TermSpec + N-term + + MOD:00783 + PSI-MOD + + + MOD:01899 + L-arginine thiazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid. + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0570 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid + RESID-systematic + + + CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys) + UniProt-feature + + + L-arginine thiazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 9 H 13 N 5 O 1 S 1 + + + + MassAvg + 239.30 + + + + MassMono + 239.084081 + + + + Origin + C, R + + + + Source + natural + + + + TermSpec + none + + MOD:00902 + MOD:01420 + MOD:01888 + PSI-MOD + + + MOD:01900 + L-cysteine 5-methyloxazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid. + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0571 + RESID + + + Cross-link 2. + + 2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr) + UniProt-feature + + + L-cysteine 5-methyloxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 S 0 + + + + DiffMono + -20.026215 + + + + Formula + C 7 H 8 N 2 O 2 S 1 + + + + MassAvg + 184.21 + + + + MassMono + 184.030649 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00905 + MOD:01422 + MOD:01888 + PSI-MOD + + + MOD:01901 + L-threonine 5-methyloxazole-4-carboxylic acid + + A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid. + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0572 + RESID + + + Cross-link 2. + + 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr) + UniProt-feature + + + L-threonine 5-methyloxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 8 H 10 N 2 O 3 + + + + MassAvg + 182.18 + + + + MassMono + 182.069142 + + + + Origin + T, T + + + + Source + natural + + + + TermSpec + none + + MOD:01422 + MOD:01888 + PSI-MOD + + + MOD:01902 + L-isoleucine oxazole-4-carboxylic acid + + A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0573 + RESID + + + Cross-link 2. + + 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser) + UniProt-feature + + + L-isoleucine oxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 9 H 12 N 2 O 2 + + + + MassAvg + 180.21 + + + + MassMono + 180.089878 + + + + Origin + I, S + + + + Source + natural + + + + TermSpec + none + + MOD:00910 + MOD:01421 + MOD:01888 + PSI-MOD + + + MOD:01903 + L-serine oxazole-4-carboxylic acid + + A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid. + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0574 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser) + UniProt-feature + + + L-serine oxazole-4-carboxylic acid + RESID-name + + + + DiffAvg + -20.03 + + + + DiffFormula + C 0 H -4 N 0 O -1 + + + + DiffMono + -20.026215 + + + + Formula + C 6 H 6 N 2 O 3 + + + + MassAvg + 154.13 + + + + MassMono + 154.037842 + + + + Origin + S, S + + + + Source + natural + + + + TermSpec + none + + MOD:01421 + MOD:01888 + PSI-MOD + + + MOD:01904 + L-serine 5-methyloxazoline-4-carboxylic acid + + A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid. + + 21568297 + PubMed + + + 21950656 + PubMed + + + AA0575 + RESID + + + Cross-link 2. + + 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid + RESID-alternate + + + 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid + RESID-systematic + + + 2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid + RESID-alternate + + + CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr) + UniProt-feature + + + L-serine 5-methyloxazoline-4-carboxylic acid + RESID-name + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 10 N 2 O 3 + + + + MassAvg + 170.17 + + + + MassMono + 170.069142 + + + + Origin + S, T + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01422 + PSI-MOD + + + MOD:01905 + 5-hydroxy-3-methyl-L-proline + + A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline. + + 7592021 + PubMed + + + 8557573 + PubMed + + + AA0473 + RESID + + + + (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid + RESID-systematic + + + 5-hydroxy-3-methyl-L-proline + RESID-name + + + 5-hydroxy-3-methylproline + RESID-alternate + + + 5Hy3MePro + PSI-MOD-label + + + beta-methyl-delta-hydroxyproline + RESID-alternate + + + MOD_RES 5-hydroxy-3-methylproline (Ile) + UniProt-feature + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 9 N 1 O 2 + + + + MassAvg + 127.14 + + + + MassMono + 127.063329 + + + + Origin + X + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + + has_functional_parent + MOD:010240 + + PSI-MOD + + + MOD:01906 + dehydromethionine + + A protein modification that effectively converts an L-methionine residue to dehydromethionine. + + 18688235 + PubMed + + + 19775156 + PubMed + + + + (3S)-3-carboxy-1-methylisothiazolidin-1-ium + PSI-MOD-alternate + + + L-dehydromethionine + PSI-MOD-alternate + + + + DiffAvg + -1.01 + + + + DiffFormula + C 0 H -1 N 0 O 0 S 0 + + + + DiffMono + -1.008374 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 131.19 + + + + MassMono + 131.039936 + + + + Origin + M + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00601 + MOD:00913 + PSI-MOD + + + MOD:01907 + dehydromethionine (from L-methioninium) + + A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine. + + 18688235 + PubMed + + + 19775156 + PubMed + + + This process accounts only for cyclizaation and not protonation. The alternative process (MOD:01906) accounts for both protonation and cyclization. + + (3S)-3-carboxy-1-methylisothiazolidin-1-ium + PSI-MOD-alternate + + + L-dehydromethionine + PSI-MOD-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.016199 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 9 N 1 O 1 S 1 + + + + MassAvg + 131.19 + + + + MassMono + 131.039936 + + + + Origin + MOD:001464 + + + + Source + artifact + + + + TermSpec + N-term + + MOD:00601 + MOD:00913 + + derives_from + MOD:014640 + + PSI-MOD + + + MOD:01908 + 4-sulfophenyl isothiocyanate alpha-amino derivatized residue + + A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. + + 14689565 + PubMed + + + 14745769 + PubMed + + + 15549660 + PubMed + + + 16526082 + PubMed + + + 261#N-term + UniMod + + + + 4-sulfophenyl isothiocyanate + UniMod-description + + + alpha-amino-[(4-sulfophenyl)carbamothioyl] residue + PSI-MOD-alternate + + + SPITC + PSI-MS-label + + + + DiffAvg + 215.24 + + + + DiffFormula + C 7 H 5 N 1 O 3 S 2 + + + + DiffMono + 214.971085 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00584 + PSI-MOD + + + MOD:01909 + 6x(13)C labeled 4-sulfophenyl isothiocyanate alpha-amino derivatized residue + + A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. + + 11467524 + PubMed + + + 16526082 + PubMed + + + 464#N-term + UniMod + + + + 4-sulfophenyl isothiocyanate (Heavy C13) + UniMod-description + + + SPITC:13C(6) + PSI-MS-label + + + + DiffAvg + 220.99 + + + + DiffFormula + (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 + + + + DiffMono + 220.991214 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00880 + PSI-MOD + + + MOD:01910 + monofluorinated residue + + A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom. + + 127 + UniMod + + + + F1Res + PSI-MOD-label + + + + DiffAvg + 17.99 + + + + DiffFormula + C 0 F 1 H -1 N 0 O 0 + + + + DiffMono + 17.990578 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00498 + PSI-MOD + + + MOD:01911 + monochlorinated residue + + A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom. + + 936 + UniMod + + + + Cl1Res + PSI-MOD-label + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00753 + PSI-MOD + + + MOD:01912 + monobrominated residue + + A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom. + + 340 + UniMod + + + + Br1Res + PSI-MOD-label + + + + DiffAvg + 78.90 + + + + DiffFormula + Br 1 C 0 H -1 N 0 O 0 + + + + DiffMono + 77.910512 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + none + + MOD:00754 + PSI-MOD + + + MOD:01913 + monochlorinated L-tryptophan + + A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom. + + 18688235 + PubMed + + + + Cl1Trp + PSI-MOD-label + + + + DiffAvg + 34.44 + + + + DiffFormula + C 0 Cl 1 H -1 N 0 O 0 + + + + DiffMono + 33.961028 + + + + Formula + C 11 Cl 1 H 9 N 2 O 1 + + + + MassAvg + 220.66 + + + + MassMono + 220.040341 + + + + Origin + W + + + + Source + artifact + + + + TermSpec + none + + MOD:01068 + MOD:01911 + PSI-MOD + + + MOD:01914 + O5-galactosyl-L-hydroxylysine + + A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine. + + 17516569 + PubMed + + + 907 + UniMod + + + Secondary to RESID:AA0028. This intermediate is rarely observed [JSG]. + PSI-MOD-slim + + Galactosyl hydroxylysine + UniMod-description + + + OGal5HyLys + PSI-MOD-label + + + + DiffAvg + 178.14 + + + + DiffFormula + C 6 H 10 N 0 O 6 + + + + DiffMono + 178.047738 + + + + Formula + C 16 H 22 N 2 O 7 + + + + MassAvg + 354.36 + + + + MassMono + 354.142701 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00037 + MOD:00396 + MOD:00476 + PSI-MOD + + + MOD:01915 + N-formyl-L-alanine + + A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine. + + 9334739 + PubMed + + + AA0576 + RESID + + + + (2S)-2-(formylamino)propanoic acid + RESID-systematic + + + 2-formamidopropanoic acid + RESID-alternate + + + 2-formamidopropionic acid + RESID-alternate + + + N-formyl-L-alanine + RESID-name + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 4 H 6 N 1 O 2 + + + + MassAvg + 100.10 + + + + MassMono + 100.039853 + + + + Origin + A + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00409 + MOD:00901 + PSI-MOD + + + MOD:01916 + O4'-(N-acetylamino)galactosyl-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine. + + 21712440 + PubMed + + + 21983924 + PubMed + + + AA0577 + RESID + + + + (2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid + RESID-systematic + + + CARBOHYD O-linked (GalNAc) + UniProt-feature + + + mucin type O-glycosyltyrosine + RESID-alternate + + + O4'-(N-acetylamino)galactosyl-L-tyrosine + RESID-name + + + O4'-(N-acetylgalactosaminyl)tyrosine + RESID-alternate + + + O4'-glycosyl-L-tyrosine + RESID-alternate + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 17 H 22 N 2 O 7 + + + + MassAvg + 366.37 + + + + MassMono + 366.142701 + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00563 + MOD:01927 + PSI-MOD + + + MOD:01917 + N6-(L-isoaspartyl)-L-lysine (Asp) + + A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water. + + 21862 + ChEBI + + + 11000116 + PubMed + + + 15044436 + PubMed + + + 18063798 + PubMed + + + 6503713 + PubMed + + + AA0294#ASP + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid + RESID-systematic + + + beta-(N6-lysyl)aspartyl acid + RESID-alternate + + + CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) + UniProt-feature + + + isoaspartyl N6-lysine + RESID-alternate + + + N(epsilon)-(beta-aspartyl)lysine + RESID-alternate + + + N6-(L-isoaspartyl)-L-lysine + RESID-name + + + XLNK-4Asp-N6Lys(Asp) + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 10 H 15 N 3 O 3 + + + + MassAvg + 225.25 + + + + MassMono + 225.111341 + + + + Origin + D, K + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01929 + PSI-MOD + + + MOD:01918 + (2S,5S)-5-hydroxylysine + + A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine. + + 19574390 + PubMed + + + 22238144 + PubMed + + + AA0578 + RESID + + + PSI-MOD-slim + + (2S,5S)-2,6-diamino-5-hydroxyhexanoic acid + RESID-systematic + + + (2S,5S)-5-hydroxylysine + RESID-name + + + 2,6-bisazanyl-5-hydroxyhexanoic acid + RESID-alternate + + + 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid + RESID-alternate + + + alpha,epsilon-diamino-delta-hydroxycaproic acid + RESID-alternate + + + L-allo-delta-hydroxylysine + RESID-alternate + + + L-threo-delta-hydroxylysine + RESID-alternate + + + MOD_RES (5S)-5-hydroxylysine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 2 O 2 + + + + MassAvg + 144.17 + + + + MassMono + 144.089878 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00037 + PSI-MOD + + + MOD:01919 + (2S,3S)-3-hydroxyaspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid. + + 10696 + ChEBI + + + 21177872 + PubMed + + + AA0579 + RESID + + + PSI-MOD-slim + + (2S,3S)-2-amino-3-hydroxybutanedioic acid + RESID-systematic + + + (2S,3S)-3-hydroxyaspartic acid + RESID-name + + + (3S)-3-hydroxy-L-aspartic acid + RESID-alternate + + + 2-amino-3-hydroxysuccinic acid + RESID-alternate + + + 2-azanyl-3-hydroxybutanedioic acid + RESID-alternate + + + 3-hydroxyaspartic acid + RESID-alternate + + + L-threo-3-hydroxyaspartic acid + RESID-alternate + + + L-threo-beta-hydroxyaspartic acid + RESID-alternate + + + MOD_RES (3S)-3-hydroxyaspartate + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 4 H 5 N 1 O 4 + + + + MassAvg + 131.09 + + + + MassMono + 131.021858 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:01926 + PSI-MOD + + + MOD:01920 + 3-hydroxy-L-histidine + + A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine. + + 21251231 + PubMed + + + AA0580 + RESID + + + + (2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid + RESID-systematic + + + 3-hydroxy-L-histidine + RESID-name + + + MOD_RES 3-hydroxyhistidine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 7 N 3 O 2 + + + + MassAvg + 153.14 + + + + MassMono + 153.053826 + + + + Origin + H + + + + Source + natural + + + + TermSpec + none + + MOD:00677 + PSI-MOD + + + MOD:01921 + D-aspartic acid (Asp) + + A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid. + + 48094 + ChEBI + + + 9384562 + PubMed + + + AA0190#ASP + RESID + + + + (2R)-2-aminobutanedioic acid + RESID-systematic + + + 2-azanylbutanedioic acid + RESID-alternate + + + aminosuccinic acid + RESID-alternate + + + D-aspartic acid + RESID-name + + + + DiffAvg + 0.00 + + + + DiffFormula + C 0 H 0 N 0 O 0 + + + + DiffMono + 0.000000 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + D + + + + Source + artifactual + + + + TermSpec + none + + MOD:00904 + MOD:01942 + PSI-MOD + + + MOD:01922 + 3-methoxydehydroalanine + + A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine. + + 19745839 + PubMed + + + AA0582 + RESID + + + + 2-amino-3-methoxyprop-2-enoic acid + RESID-systematic + + + 3-methoxydehydroalanine + RESID-name + + + 3-methoxydidehydroalanine + RESID-alternate + + + + DiffAvg + 12.01 + + + + DiffFormula + C 1 H 0 N 0 O 0 + + + + DiffMono + 12.000000 + + + + Formula + C 4 H 5 N 1 O 2 + + + + MassAvg + 99.09 + + + + MassMono + 99.032028 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + + has_functional_parent + MOD:001890 + + PSI-MOD + + + MOD:01923 + N6-(L-aspartyl)-L-lysine + + A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water. + + 15044436 + PubMed + + + AA0583 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid + RESID-systematic + + + alpha-(N6-lysyl)aspartyl acid + RESID-alternate + + + aspartyl N6-lysine + RESID-alternate + + + N(epsilon)-(alpha-aspartyl)lysine + RESID-alternate + + + N6-(L-aspartyl)-L-lysine + RESID-name + + + XLNK-4Asp-N6Lys(Asp) + PSI-MOD-label + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 10 H 16 N 3 O 4 + + + + MassAvg + 242.26 + + + + MassMono + 242.114081 + + + + Origin + D, K + + + + Source + natural + + + + TermSpec + C-term + + MOD:00688 + MOD:00904 + MOD:00954 + MOD:01875 + PSI-MOD + + + MOD:01924 + S-octanoyl-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine. + + 12591875 + PubMed + + + 16342964 + PubMed + + + AA0584 + RESID + + + + (2S)-2-amino-3-(octanoylsulfanyl)propanoic acid + RESID-systematic + + + 2-amino-3-(octanoylthio)propanoic acid + RESID-alternate + + + ACT_SITE Acyl-thioester intermediate + UniProt-feature + + + cysteine octanoate thioester + RESID-alternate + + + S-octanoyl-L-cysteine + RESID-name + + + + DiffAvg + 126.20 + + + + DiffFormula + C 8 H 14 N 0 O 1 S 0 + + + + DiffMono + 126.104465 + + + + Formula + C 11 H 19 N 1 O 2 S 1 + + + + MassAvg + 229.34 + + + + MassMono + 229.113650 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00666 + MOD:00672 + MOD:00905 + PSI-MOD + + + MOD:01925 + (2S,5R)-5-hydroxylysine + + A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine. + + 18040 + ChEBI + + + 13375629 + PubMed + + + 15504407 + PubMed + + + 16101297 + PubMed + + + 2857489 + PubMed + + + AA0028 + RESID + + + PSI-MOD-slim + + (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid + RESID-systematic + + + (2S,5R)-5-hydroxylysine + RESID-name + + + 2,6-bisazanyl-5-hydroxyhexanoic acid + RESID-alternate + + + 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid + RESID-alternate + + + 5-hydroxylated L-lysine + PSI-MOD-alternate + + + 5HyLys + PSI-MOD-label + + + alpha,epsilon-diamino-delta-hydroxycaproic acid + RESID-alternate + + + L-erythro-delta-hydroxylysine + RESID-alternate + + + MOD_RES (2S,5R)-5-hydroxylysine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 2 O 2 + + + + MassAvg + 144.17 + + + + MassMono + 144.089878 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00037 + PSI-MOD + + + MOD:01926 + 3-hydroxy-L-aspartic acid + + A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues. + + 35#D + UniMod + + + PSI-MOD-slim + + (2S)-2-amino-3-hydroxybutanedioic acid + PSI-MOD-alternate + + + (2S)-3-hydroxyaspartic acid + PSI-MOD-alternate + + + 3HyAsp + PSI-MOD-label + + + erythro-beta-hydroxylated L-aspartic acid + PSI-MOD-alternate + + + hydroxylationd + OMSSA-label + + + monohydroxylated aspartic acid + PSI-MOD-alternate + + + Oxidation + PSI-MS-label + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 4 H 5 N 1 O 4 + + + + MassAvg + 131.09 + + + + MassMono + 131.021858 + + + + Origin + D + + + + Source + natural + + + + TermSpec + none + + MOD:00425 + MOD:00904 + PSI-MOD + + + MOD:01927 + O-glycosyl-L-tyrosine + + A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine. + + 18688235 + PubMed + + + PSI-MOD-slim + + OGlycoTyr + PSI-MOD-label + + + + Origin + Y + + + + Source + natural + + + + TermSpec + none + + MOD:00396 + MOD:00919 + PSI-MOD + + + MOD:01928 + N-(L-isoaspartyl)-glycine + + A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine. + + 21479 + ChEBI + + + 1826288 + PubMed + + + AA0126 + RESID + + + Cross-link 2. + + (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid + RESID-systematic + + + 2-amino-N4-(carboxymethyl)-butanediamic acid + RESID-alternate + + + isoaspartyl glycine + RESID-alternate + + + N-(L-isoaspartyl)-glycine + RESID-name + + + N-beta-aspartylglycine + RESID-alternate + + + N4-(carboxymethyl)-asparagine + RESID-alternate + + + XLNK-4Asp-NGly + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 7 N 2 O 3 + + + + MassAvg + 155.13 + + + + MassMono + 155.045667 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00688 + MOD:00908 + PSI-MOD + + + MOD:01929 + N6-(L-isoaspartyl)-L-lysine + + A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine. + + 21862 + ChEBI + + + 0 + DeltaMass + + + 11000116 + PubMed + + + 6503713 + PubMed + + + AA0294 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid + RESID-systematic + + + beta-(N6-lysyl)aspartyl acid + RESID-alternate + + + CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) + UniProt-feature + + + isoaspartyl N6-lysine + RESID-alternate + + + N(epsilon)-(beta-aspartyl)lysine + RESID-alternate + + + N-(beta-Aspartyl)-Lysine (Crosslink) + DeltaMass-label + + + N6-(L-isoaspartyl)-L-lysine + RESID-name + + + XLNK-4Asp-N6Lys + PSI-MOD-label + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 10 H 15 N 3 O 3 + + + + MassAvg + 225.25 + + + + MassMono + 225.111341 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00688 + MOD:01875 + PSI-MOD + + + MOD:01930 + D-aspartic acid (Asn) + + A protein modification that effectively converts an L-asparagine residue to D-aspartic acid. + + 48094 + ChEBI + + + 9384562 + PubMed + + + AA0190#ASN + RESID + + + + (2R)-2-aminobutanedioic acid + RESID-systematic + + + 2-azanylbutanedioic acid + RESID-alternate + + + aminosuccinic acid + RESID-alternate + + + D-aspartic acid + RESID-name + + + + DiffAvg + 0.98 + + + + DiffFormula + C 0 H -1 N -1 O 1 + + + + DiffMono + 0.984016 + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + N + + + + Source + artifactual + + + + TermSpec + none + + MOD:00903 + MOD:01942 + PSI-MOD + + + MOD:01931 + N6-phospho-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine. + + 20144148 + PubMed + + + AA0585 + RESID + + + + (2S)-2-amino-6-(phosphonoamino)hexanoic acid + RESID-systematic + + + (2S)-2-azanyl-6-(phosphonoamino)hexanoic acid + RESID-alternate + + + 6-phospholysine + RESID-alternate + + + N(6)-phosphonolysine + RESID-alternate + + + N(epsilon)-phospholysine + RESID-alternate + + + N(epsilon)-phosphonolysine + RESID-alternate + + + N(epsilon)-phosphonyllysine + RESID-alternate + + + N(epsilon)-phosphoryllysine + RESID-alternate + + + N6-phospho-L-lysine + RESID-name + + + + DiffAvg + 79.98 + + + + DiffFormula + C 0 H 1 N 0 O 3 P 1 + + + + DiffMono + 79.966331 + + + + Formula + C 6 H 13 N 2 O 4 P 1 + + + + MassAvg + 208.15 + + + + MassMono + 208.061294 + + + + Origin + K + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00912 + MOD:01456 + PSI-MOD + + + MOD:01932 + L-lysinonorleucine + + A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.. + + 5117030 + PubMed + + + 5817620 + PubMed + + + 5879466 + PubMed + + + 6030254 + PubMed + + + AA0586 + RESID + + + Cross-link 2. + + (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid + RESID-systematic + + + (2S,2'S)-6,6'-iminobis(2-aminohexanoic acid) + RESID-alternate + + + 6-(N6-L-lysino)-L-norleucine + RESID-alternate + + + L-lysinonorleucine + RESID-name + + + lysinonorleucine + RESID-alternate + + + lysinorleucine [misspelling] + RESID-alternate + + + lysylnorleucine + RESID-alternate + + + N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 12 H 21 N 3 O 2 + + + + MassAvg + 239.32 + + + + MassMono + 239.163377 + + + + Origin + K, K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:00946 + PSI-MOD + + + MOD:01933 + desmosine + + A protein modification that effectively cross-links four L-lysine residues to form desmosine. + + 37629 + ChEBI + + + 13941623 + PubMed + + + 14109938 + PubMed + + + 14109939 + PubMed + + + 5839176 + PubMed + + + AA0587 + RESID + + + Cross-link 4. + + 4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium + RESID-systematic + + + 6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine + RESID-alternate + + + desmosine + RESID-name + + + + DiffAvg + -58.15 + + + + DiffFormula + C 0 H -16 N -3 O 0 + + + + DiffMono + -58.134971 + + + + FormalCharge + 1+ + + + + Formula + C 24 H 32 N 5 O 4 + + + + MassAvg + 454.55 + + + + MassMono + 454.244881 + + + + Origin + K, K, K, K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01425 + PSI-MOD + + + MOD:01934 + isodesmosine + + A protein modification that effectively cross-links four L-lysine residues to form isodesmosine. + + 37629 + ChEBI + + + 13941623 + PubMed + + + 14109938 + PubMed + + + 14109939 + PubMed + + + 5839176 + PubMed + + + AA0588 + RESID + + + Cross-link 4. + + 2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium + RESID-systematic + + + 6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine + RESID-alternate + + + isodesmosine + RESID-name + + + + DiffAvg + -58.15 + + + + DiffFormula + C 0 H -16 N -3 O 0 + + + + DiffMono + -58.134971 + + + + FormalCharge + 1+ + + + + Formula + C 24 H 32 N 5 O 4 + + + + MassAvg + 454.55 + + + + MassMono + 454.244881 + + + + Origin + K, K, K, K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + MOD:01425 + PSI-MOD + + + MOD:01935 + O-glucosyl-L-hydroxylysine + + modification from RESID + + 22045808 + PubMed + + + AA0589 + RESID + + + + (D-glucopyranosyl)oxy-L-lysine + RESID-systematic + + + O-glucosyl-L-hydroxylysine + RESID-name + + + + DiffAvg + 178.14 + + + + DiffFormula + C 6 H 10 N 0 O 6 + + + + DiffMono + 178.047738 + + + + Formula + C 12 H 22 N 2 O 7 + + + + MassAvg + 306.32 + + + + MassMono + 306.142701 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01047 + PSI-MOD + + + MOD:01936 + N6-oleoyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine. + + 20942504 + PubMed + + + AA0590 + RESID + + + + (2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid + RESID-systematic + + + N6-[(9Z)-1-oxo-9-octadecenyl]lysine + RESID-alternate + + + N6-oleoyl-L-lysine + RESID-name + + + + DiffAvg + 264.45 + + + + DiffFormula + C 18 H 32 N 0 O 1 + + + + DiffMono + 264.245316 + + + + Formula + C 24 H 44 N 2 O 2 + + + + MassAvg + 392.63 + + + + MassMono + 392.340279 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:01875 + PSI-MOD + + + MOD:01937 + N-palmitoyl-L-methionine + + A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine. + + 20942504 + PubMed + + + AA0591 + RESID + + + + (2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid + RESID-systematic + + + 2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid + RESID-alternate + + + LIPID N-palmitoyl methionine + UniProt-feature + + + N-(1-oxohexadecyl)methionine + RESID-alternate + + + N-palmitoyl-L-methionine + RESID-name + + + + DiffAvg + 238.41 + + + + DiffFormula + C 16 H 30 N 0 O 1 S 0 + + + + DiffMono + 238.229666 + + + + Formula + C 21 H 40 N 1 O 2 S 1 + + + + MassAvg + 370.62 + + + + MassMono + 370.277976 + + + + Origin + M + + + + Source + natural + + + + TermSpec + N-term + + MOD:00913 + MOD:01685 + PSI-MOD + + + MOD:01938 + 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asn) + + A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia. + + AA0592#ASN + RESID + + + Cross-link 2. + + (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid + RESID-systematic + + + 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid + RESID-name + + + aspartimide cysteine + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 S 0 + + + + DiffMono + -17.026549 + + + + Formula + C 7 H 8 N 2 O 3 S 1 + + + + MassAvg + 200.21 + + + + MassMono + 200.025563 + + + + Origin + C, N + + + + Source + natural + + + + TermSpec + none + + MOD:00903 + MOD:01945 + PSI-MOD + + + MOD:01939 + 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asp) + + A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule. + + AA0592#ASP + RESID + + + Cross-link 2. + + (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid + RESID-systematic + + + 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid + RESID-name + + + aspartimide cysteine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 8 N 2 O 3 S 1 + + + + MassAvg + 200.21 + + + + MassMono + 200.025563 + + + + Origin + C, D + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01945 + PSI-MOD + + + MOD:01940 + 2-(2-aminosuccinimidyl)pentanedioic acid (Asn) + + A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia. + + AA0593#ASN + RESID + + + Cross-link 2. + + (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid + RESID-systematic + + + 2-(2-aminosuccinimidyl)pentanedioic acid + RESID-name + + + aspartimide glutamic acid + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 9 H 10 N 2 O 5 + + + + MassAvg + 226.19 + + + + MassMono + 226.058971 + + + + Origin + E, N + + + + Source + natural + + + + TermSpec + none + + MOD:00903 + MOD:01946 + PSI-MOD + + + MOD:01941 + 2-(2-aminosuccinimidyl)pentanedioic acid (Asp) + + A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule. + + AA0593#ASP + RESID + + + Cross-link 2. + + (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid + RESID-systematic + + + 2-(2-aminosuccinimidyl)pentanedioic acid + RESID-name + + + aspartimide glutamic acid + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 9 H 10 N 2 O 5 + + + + MassAvg + 226.19 + + + + MassMono + 226.058971 + + + + Origin + D, E + + + + Source + natural + + + + TermSpec + none + + MOD:00904 + MOD:01946 + PSI-MOD + + + MOD:01942 + D-aspartic acid + + A protein modification that effectively converts a source amino acid residue to D-aspartic acid. + + 48094 + ChEBI + + + 9384562 + PubMed + + + AA0190 + RESID + + + + (2R)-2-aminobutanedioic acid + RESID-systematic + + + 2-azanylbutanedioic acid + RESID-alternate + + + aminosuccinic acid + RESID-alternate + + + D-aspartic acid + RESID-name + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 4 H 5 N 1 O 3 + + + + MassAvg + 115.09 + + + + MassMono + 115.026943 + + + + Origin + X + + + + Source + artifactual + + + + TermSpec + none + + MOD:00664 + MOD:00859 + PSI-MOD + + + MOD:01943 + pyrrolidione ring crosslinked residues + + A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring. + + 18688235 + PubMed + + + MOD:00033 + PSI-MOD + + + MOD:01944 + 2-aminosuccinimide ring crosslinked residues + + A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue. + + 18688235 + PubMed + + + Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. + PSI-MOD-slim + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00033 + MOD:00859 + PSI-MOD + + + MOD:01945 + 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid + + A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue. + + 18688235 + PubMed + + + Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 6 N 2 O 3 + + + + MassAvg + 154.13 + + + + MassMono + 154.037842 + + + + Origin + C, X + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00905 + MOD:01944 + PSI-MOD + + + MOD:01946 + 2-(2-aminosuccinimidyl)pentanedioic acid + + A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid\n residue. + + 18688235 + PubMed + + + Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 6 H 6 N 2 O 3 + + + + MassAvg + 154.13 + + + + MassMono + 154.037842 + + + + Origin + E, X + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00906 + MOD:01944 + PSI-MOD + + + MOD:01947 + O-(L-isoaspartyl)-L-threonine (cross-link) + + A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form O-(L-isoaspartyl)-L-threonine. + + 17157318 + PubMed + + + 8706862 + PubMed + + + AA0525#TDX + RESID + + + Cross-link 2. + + (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid + RESID-alternate + + + CROSSLNK isoaspartyl threonine ester (Thr-Asp) + UniProt-feature + + + O(beta)-(beta-aspartyl)threonine + RESID-alternate + + + O-(L-isoaspartyl)-L-threonine + RESID-name + + + O3-(isoaspartyl)-threonine + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 + + + + DiffMono + -18.010565 + + + + Formula + C 8 H 10 N 2 O 4 + + + + MassAvg + 198.18 + + + + MassMono + 198.064057 + + + + Origin + D, T + + + + Source + natural + + + + TermSpec + none + + MOD:00885 + MOD:00904 + MOD:00954 + MOD:01978 + PSI-MOD + + + MOD:01948 + labionin + + A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin. + + 20082397 + PubMed + + + AA0594 + RESID + + + Cross-link 3. + + (2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid + RESID-systematic + + + (2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid + RESID-alternate + + + (2S,4S,8R)-labionin + RESID-alternate + + + labionin + RESID-name + + + + DiffAvg + -36.03 + + + + DiffFormula + C 0 H -4 N 0 O -2 S 0 + + + + DiffMono + -36.021129 + + + + Formula + C 9 H 11 N 3 O 3 S 1 + + + + MassAvg + 241.26 + + + + MassMono + 241.052112 + + + + Origin + C, S, S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01993 + PSI-MOD + + + MOD:01949 + coelenterazine + + A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine. + + 2311 + ChEBI + + + 10830969 + PubMed + + + 11572972 + PubMed + + + 19833098 + PubMed + + + AA0595 + RESID + + + Cross-link 3. + + 8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one + RESID-systematic + + + coelenterazine + RESID-name + + + Oplophorus luciferin + RESID-alternate + + + + DiffAvg + -50.06 + + + + DiffFormula + C -1 H -6 N 0 O -2 + + + + DiffMono + -50.036779 + + + + Formula + C 26 H 21 N 3 O 3 + + + + MassAvg + 423.47 + + + + MassMono + 423.158292 + + + + Origin + F, Y, Y + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:00033 + MOD:00914 + MOD:00919 + PSI-MOD + + + MOD:01950 + L-isoglutamyl histamine + + A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine. + + 23022564 + PubMed + + + AA0596 + RESID + + + + (2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid + RESID-systematic + + + (gamma-glutamyl)histamine + RESID-alternate + + + L-isoglutamyl histamine + RESID-name + + + + DiffAvg + 94.12 + + + + DiffFormula + C 5 H 6 N 2 O 0 + + + + DiffMono + 94.053098 + + + + Formula + C 10 H 14 N 4 O 2 + + + + MassAvg + 222.25 + + + + MassMono + 222.111676 + + + + Origin + Q + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + PSI-MOD + + + MOD:01951 + O-(L-isoglutamyl)-L-serine (Gln-Ser) + + A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine. + + 17051152 + PubMed + + + AA0597#QSX + RESID + + + Cross-link 2. + + (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid + RESID-systematic + + + O(beta)-(gamma-glutamyl)serine + RESID-alternate + + + O-(L-isoglutamyl)-L-serine + RESID-name + + + O3-(isoglutamyl)-serine + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 8 H 10 N 2 O 4 + + + + MassAvg + 198.18 + + + + MassMono + 198.064057 + + + + Origin + Q, S + + + + Source + natural + + + + TermSpec + none + + MOD:00907 + MOD:00946 + MOD:01977 + PSI-MOD + + + MOD:01952 + O-(L-isoglutamyl)-L-threonine (cross-link) + + A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine. + + 17051152 + PubMed + + + AA0536#TQX + RESID + + + Cross-link 2. + + (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid + RESID-alternate + + + 5-(threon-O3-yl)glutamate + RESID-alternate + + + O(beta)-(gamma-glutamyl)threonine + RESID-alternate + + + O-(L-isoglutamyl)-L-threonine + RESID-name + + + O3-(isoglutamyl)threonine + RESID-alternate + + + + DiffAvg + -17.03 + + + + DiffFormula + C 0 H -3 N -1 O 0 + + + + DiffMono + -17.026549 + + + + Formula + C 9 H 12 N 2 O 4 + + + + MassAvg + 212.20 + + + + MassMono + 212.079707 + + + + Origin + Q, T + + + + Source + natural + + + + TermSpec + none + + MOD:00885 + MOD:00907 + MOD:01979 + PSI-MOD + + + MOD:01953 + tetrakis-L-cysteinyl tetrairon octanitrosyl + + A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl. + + 21182249 + PubMed + + + AA0599 + RESID + + + Cross-link 4. + + + DiffAvg + 459.40 + + + + DiffFormula + C 0 Fe 4 H -4 N 8 O 8 S 0 + + + + DiffMono + 459.692359 + + + + Formula + C 12 Fe 4 H 16 N 12 O 12 S 4 + + + + MassAvg + 871.95 + + + + MassMono + 871.729098 + + + + Origin + C, C, C, C + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00738 + MOD:00905 + PSI-MOD + + + MOD:01954 + dehydroalanine (Sec) + + A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine. + + 17123 + ChEBI + + + 10220322 + PubMed + + + 12781460 + PubMed + + + 1547888 + PubMed + + + 1815586 + PubMed + + + 20805503 + PubMed + + + 21420488 + PubMed + + + 22031445 + PubMed + + + 2914619 + PubMed + + + 7947813 + PubMed + + + 8239649 + PubMed + + + AA0181 + RESID + + + + 2,3-didehydroalanine + RESID-alternate + + + 2-aminoacrylic acid + RESID-alternate + + + 2-aminopropenoic acid + RESID-systematic + + + 4-methylidene-imidazole-5-one (MIO) active site + RESID-alternate + + + anhydroserine + RESID-alternate + + + dehydroalanine + RESID-name + + + Dha + RESID-alternate + + + + DiffAvg + -80.99 + + + + DiffFormula + C 0 H -2 N 0 O 0 Se -1 + + + + DiffMono + -81.932171 + + + + Formula + C 3 H 3 N 1 O 1 + + + + MassAvg + 69.06 + + + + MassMono + 69.021464 + + + + Origin + U + + + + Source + natural + + + + TermSpec + none + + MOD:01158 + MOD:01168 + PSI-MOD + + + MOD:01955 + L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide + + modification from RESID + + 21499260 + PubMed + + + AA0600 + RESID + + + Cross-link 7. + + 4Mn-Ca-5O cluster + RESID-alternate + + + L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide + RESID-name + + + mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese + RESID-systematic + + + photosystem II catalytic cluster + RESID-alternate + + + + DiffAvg + 333.78 + + + + DiffFormula + C 0 Ca 1 H -6 Mn 4 N 0 O 5 + + + + DiffMono + 333.642394 + + + + Formula + C 32 Ca 1 H 38 Mn 4 N 9 O 23 + + + + MassAvg + 1176.53 + + + + MassMono + 1175.922825 + + + + Origin + A, D, D, E, E, E, H + + + + Source + natural + + + + TermSpec + C-term + + MOD:00740 + MOD:00901 + MOD:00904 + MOD:00906 + MOD:00909 + MOD:01482 + PSI-MOD + + + MOD:01956 + (3R)-3-hydroxy-L-arginine + + A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine. + + 10094780 + PubMed + + + 23103944 + PubMed + + + 786730 + PubMed + + + AA0601 + RESID + + + + (2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid + RESID-systematic + + + (3R)-3-hydroxy-L-arginine + RESID-name + + + 2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer] + RESID-alternate + + + 2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer] + RESID-alternate + + + 2-amino-5-guanidino-3-hydroxypentanoic acid + RESID-alternate + + + beta-hydroxyarginine + RESID-alternate + + + C(beta)-hydroxyarginine + RESID-alternate + + + MOD_RES (3R)-3-hydroxyarginine + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 6 H 12 N 4 O 2 + + + + MassAvg + 172.19 + + + + MassMono + 172.096026 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00682 + PSI-MOD + + + MOD:01957 + 2-hydroxyproline + + A protein modification that effectively converts an L-proline residue to 2-hydroxyproline. + + 23385463 + PubMed + + + AA0602 + RESID + + + + (2R)-2-hydroxypyrrolidine-2-carboxylic acid + RESID-systematic + + + 2-hydroxyproline + RESID-name + + + 2-oxidanylpyrrolidine-2-carboxylic acid + RESID-alternate + + + alpha-hydroxyproline + RESID-alternate + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 7 N 1 O 2 + + + + MassAvg + 113.12 + + + + MassMono + 113.047678 + + + + Origin + P + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01024 + PSI-MOD + + + MOD:01958 + bis-L-cysteinyl bisglutathion-S-yl diiron disulfide + + A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide. + + 17121859 + PubMed + + + AA0603 + RESID + + + Cross-link 2. + + bis-L-cysteinyl bisglutathion-S-yl diiron disulfide + RESID-name + + + di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron + RESID-systematic + + + mitochondrial glutaredoxin 2 dimer iron-sulfur cluster + RESID-alternate + + + plant glutaredoxin C1 dimer iron-sulfur cluster + RESID-alternate + + + + DiffAvg + 786.42 + + + + DiffFormula + C 20 Fe 2 H 30 N 6 O 12 S 4 + + + + DiffMono + 785.950329 + + + + Formula + C 26 Fe 2 H 40 N 8 O 14 S 6 + + + + MassAvg + 992.70 + + + + MassMono + 991.968699 + + + + Origin + C, C + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + PSI-MOD + + + MOD:01959 + tris-L-cysteinyl L-glutamato tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide. + + 21167158 + PubMed + + + AA0604 + RESID + + + Cross-link 4. + + tris-L-cysteinyl L-glutamato tetrairon tetrasulfide + RESID-name + + + tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon + RESID-systematic + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.596734 + + + + Formula + C 14 Fe 4 H 18 N 4 O 6 S 7 + + + + MassAvg + 786.12 + + + + MassMono + 785.666881 + + + + Origin + C, C, C, E + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00906 + PSI-MOD + + + MOD:01960 + tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide + + A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide. + + 11796730 + PubMed + + + AA0605 + RESID + + + Cross-link 4. + + METAL Iron-sulfur (4Fe-4S) + UniProt-feature + + + tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide + RESID-name + + + tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon + RESID-systematic + + + + DiffAvg + 347.59 + + + + DiffFormula + C 0 Fe 4 H -4 N 0 O 0 S 4 + + + + DiffMono + 347.596734 + + + + Formula + C 14 Fe 4 H 19 N 5 O 5 S 7 + + + + MassAvg + 785.14 + + + + MassMono + 784.682866 + + + + Origin + C, C, C, Q + + + + Source + natural + + + + TermSpec + none + + MOD:00739 + MOD:00905 + MOD:00907 + PSI-MOD + + + MOD:01961 + O-(L-isoglutamyl)-L-threonine (THR) + + OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785. + + 16618936 + PubMed + + + 17051152 + PubMed + + + 17687277 + PubMed + + + 18555071 + PubMed + + + AA0536#THR + RESID + + + + (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid + RESID-alternate + + + 5-(threon-O3-yl)glutamate + RESID-alternate + + + O(beta)-(gamma-glutamyl)threonine + RESID-alternate + + + O-(L-isoglutamyl)-L-threonine + RESID-name + + + O3-(isoglutamyl)threonine + RESID-alternate + + + + DiffAvg + 129.12 + + + + DiffFormula + C 5 H 7 N 1 O 3 + + + + DiffMono + 129.042593 + + + + Formula + C 9 H 14 N 2 O 5 + + + + MassAvg + 230.22 + + + + MassMono + 230.090272 + + + + Origin + T + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01962 + N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine + + A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine. + + 12186869 + PubMed + + + 19236052 + PubMed + + + AA0606 + RESID + + + + (2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid + RESID-systematic + + + DABA + RESID-alternate + + + DATDH + RESID-alternate + + + DiNAcBac + RESID-alternate + + + N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine + RESID-name + + + N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine + RESID-alternate + + + N4-[N,N-diacetylbacillosaminyl]asparagine + RESID-alternate + + + N4-[N2,N4-diacetylbacillosaminyl]asparagine + RESID-alternate + + + + DiffAvg + 228.25 + + + + DiffFormula + C 10 H 16 N 2 O 4 + + + + DiffMono + 228.111007 + + + + Formula + C 14 H 22 N 4 O 6 + + + + MassAvg + 342.35 + + + + MassMono + 342.153934 + + + + Origin + N + + + + Source + natural + + + + TermSpec + none + + MOD:00160 + PSI-MOD + + + MOD:01963 + O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine. + + 23030644 + PubMed + + + AA0607 + RESID + + + + (2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid + RESID-systematic + + + DABA + RESID-alternate + + + DATDH + RESID-alternate + + + DiNAcBac + RESID-alternate + + + O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine + RESID-name + + + O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine + RESID-alternate + + + O-[N,N-diacetylbacillosaminyl]serine + RESID-alternate + + + O-[N2,N4-diacetylbacillosaminyl]serine + RESID-alternate + + + + DiffAvg + 228.25 + + + + DiffFormula + C 10 H 16 N 2 O 4 + + + + DiffMono + 228.111007 + + + + Formula + C 13 H 21 N 3 O 6 + + + + MassAvg + 315.33 + + + + MassMono + 315.143035 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:01964 + O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine + + A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine. + + 17804791 + PubMed + + + AA0608 + RESID + + + + (2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid + RESID-systematic + + + GATDH + RESID-alternate + + + O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine + RESID-alternate + + + O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine + RESID-name + + + O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine + RESID-alternate + + + + DiffAvg + 274.27 + + + + DiffFormula + C 11 H 18 N 2 O 6 + + + + DiffMono + 274.116486 + + + + Formula + C 14 H 23 N 3 O 8 + + + + MassAvg + 361.35 + + + + MassMono + 361.148515 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00002 + PSI-MOD + + + MOD:01965 + 2xC(13),3x(2)H labeled N6-acetyl-L-lysine + + A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine. + + 18688235 + PubMed + + + + Acetate labeling reagent (K) (heavy form, +5amu) + PSI-MOD-alternate + + + COFRADIC heavy acetyl 13C2 2H3 + PSI-MOD-alternate + + + + DiffAvg + 47.04 + + + + DiffFormula + (13)C 2 (1)H -1 (2)H 3 O 1 + + + + DiffMono + 47.036105 + + + + Formula + (12)C 6 (13)C 2 (1)H 11 (2)H 3 N 2 O 2 + + + + MassAvg + 175.13 + + + + MassMono + 175.131068 + + + + Origin + K + + + + Source + artifact + + + + TermSpec + none + + MOD:00064 + MOD:01428 + MOD:01431 + PSI-MOD + + + MOD:01966 + L-methionine (R)-sulfoxide + + OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720. + + 45764 + ChEBI + + + 21406390 + PubMed + + + 22116028 + PubMed + + + 23911929 + PubMed + + + AA0581 + RESID + + + + (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid + RESID-systematic + + + L-methionine (R)-S-oxide + RESID-alternate + + + L-methionine (R)-sulfoxide + RESID-name + + + MOD_RES Methionine (R)-sulfoxide + UniProt-feature + + + + DiffAvg + 16.00 + + + + DiffFormula + C 0 H 0 N 0 O 1 S 0 + + + + DiffMono + 15.994915 + + + + Formula + C 5 H 9 N 1 O 2 S 1 + + + + MassAvg + 147.19 + + + + MassMono + 147.035400 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + 1 + PSI-MOD + + + MOD:01967 + omega-N-(N-acetylamino)glucosyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to omega-N-(N-acetylamino)glucosyl-L-arginine. + + 23955153 + PubMed + + + AA0609 + RESID + + + + (2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid + RESID-systematic + + + N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine + RESID-alternate + + + N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine + RESID-alternate + + + N(omega)-(2-N-acetylaminoglucosyl)arginine + RESID-alternate + + + NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine + RESID-alternate + + + NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine + RESID-alternate + + + NG-(2-N-acetylaminoglucosyl)arginine + RESID-alternate + + + omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine + RESID-alternate + + + omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine + RESID-alternate + + + omega-N-(2-N-acetylaminoglucosyl)arginine + RESID-alternate + + + omega-N-(N-acetylamino)glucosyl-L-arginine + RESID-name + + + + DiffAvg + 203.19 + + + + DiffFormula + C 8 H 13 N 1 O 5 + + + + DiffMono + 203.079373 + + + + Formula + C 14 H 25 N 5 O 6 + + + + MassAvg + 359.38 + + + + MassMono + 359.180484 + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00448 + MOD:01980 + PSI-MOD + + + MOD:01968 + (2R,3R,2'R)-3-methyllanthionine + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine. + + 23314913 + PubMed + + + AA0610 + RESID + + + Cross-link 2. + + (2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid + RESID-systematic + + + (2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid + RESID-alternate + + + (2R,3R,2'R)-3-methyllanthionine + RESID-name + + + (2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid + RESID-alternate + + + (2R,3R,6R)-3-methyllanthionine + RESID-alternate + + + 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid + RESID-alternate + + + 3-methyl-L,L-lanthionine + RESID-alternate + + + cysteine-3-L-butyrine thioether + RESID-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 10 N 2 O 2 S 1 + + + + MassAvg + 186.23 + + + + MassMono + 186.046299 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:01981 + PSI-MOD + + + MOD:01969 + S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine. + + 9398217 + PubMed + + + AA0611 + RESID + + + + (2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid + RESID-systematic + + + ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate + UniProt-feature + + + S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine + RESID-name + + + S-(glutathion-1-yl)-L-cysteine + RESID-alternate + + + + DiffAvg + 289.31 + + + + DiffFormula + C 10 H 15 N 3 O 5 S 1 + + + + DiffMono + 289.073242 + + + + Formula + C 13 H 20 N 4 O 6 S 2 + + + + MassAvg + 392.44 + + + + MassMono + 392.082426 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00860 + MOD:00905 + PSI-MOD + + + MOD:01970 + 5-glutamyl glutamic acid + + A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid. + + 10747868 + PubMed + + + 15525938 + PubMed + + + 1680872 + PubMed + + + 23434852 + PubMed + + + AA0612 + RESID + + + 450 + UniMod + + + + (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid + RESID-systematic + + + (2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid + RESID-alternate + + + 2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid + RESID-alternate + + + 5-glutamyl glutamic acid + RESID-name + + + gamma-glutamylglutamate + RESID-alternate + + + Glu + UniMod-interim + + + isoglutamyl glutamic acid + RESID-alternate + + + isoglutamyl monoglutamic acid + RESID-alternate + + + MOD_RES 5-glutamyl glutamate + UniProt-feature + + + monoglutamyl + UniMod-description + + + N alpha -(gamma-Glutamyl)-Glu + DeltaMass-label + + + N-(gamma-L-glutamyl)-L-glutamic acid + RESID-alternate + + + + DiffAvg + 129.12 + + + + DiffFormula + C 5 H 7 N 1 O 3 + + + + DiffMono + 129.042593 + + + + Formula + C 10 H 14 N 2 O 6 + + + + MassAvg + 258.23 + + + + MassMono + 258.085186 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00207 + PSI-MOD + + + MOD:01971 + 5-glutamyl N2-ornithine + + A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine. + + 23434852 + PubMed + + + AA0613 + RESID + + + + (2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid + RESID-alternate + + + (2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid + RESID-systematic + + + 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid + RESID-alternate + + + 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid + RESID-alternate + + + 5-glutamyl N2-ornithine + RESID-name + + + gamma-glutamylornithine + RESID-alternate + + + MOD_RES 5-glutamyl N2-ornithine + UniProt-feature + + + N2-(gamma-glutamyl)ornithine + RESID-alternate + + + N2-(L-isoglutamyl)-L-ornithine + RESID-alternate + + + + DiffAvg + 114.15 + + + + DiffFormula + C 5 H 10 N 2 O 1 + + + + DiffMono + 114.079313 + + + + Formula + C 10 H 17 N 3 O 4 + + + + MassAvg + 243.26 + + + + MassMono + 243.121906 + + + + Origin + E + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00674 + MOD:00906 + PSI-MOD + + + MOD:01972 + 5-glutamyl coenzyme A thioester + + A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester. + + 16253988 + PubMed + + + 20977214 + PubMed + + + 7915164 + PubMed + + + AA0614 + RESID + + + + (2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid + RESID-alternate + + + (2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid + RESID-systematic + + + 5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester + RESID-alternate + + + 5-glutamyl coenzyme A thioester + RESID-name + + + 5-glutamyl coenzyme A thioester intermediate + UniProt-feature + + + + DiffAvg + 749.52 + + + + DiffFormula + C 21 H 34 N 7 O 15 P 3 S 1 + + + + DiffMono + 749.104644 + + + + Formula + C 26 H 41 N 8 O 18 P 3 S 1 + + + + MassAvg + 878.63 + + + + MassMono + 878.147237 + + + + Origin + E + + + + Source + natural + + + + TermSpec + none + + MOD:00860 + MOD:00861 + MOD:00906 + PSI-MOD + + + MOD:01973 + N6-(3-phosphoglyceryl)-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine. + + 23908237 + PubMed + + + AA0615 + RESID + + + + (2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid + RESID-alternate + + + (2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid + RESID-systematic + + + 3-phosphoglyceryl-lysine + RESID-alternate + + + N6-(3-phosphoglyceryl)-L-lysine + RESID-name + + + + DiffAvg + 168.04 + + + + DiffFormula + C 3 H 5 N 0 O 6 P 1 + + + + DiffMono + 167.982375 + + + + Formula + C 9 H 17 N 2 O 7 P 1 + + + + MassAvg + 296.22 + + + + MassMono + 296.077338 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00861 + MOD:01875 + PSI-MOD + + + MOD:01974 + S-methyl-L-methionine + + A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine. + + 17728 + ChEBI + + + 23532849 + PubMed + + + AA0616 + RESID + + + + (2S)-2-amino-4-(dimethylsulfonio)butanoate + RESID-alternate + + + (3S)-(3-amino-3-carboxypropyl)dimethylsulfanium + RESID-systematic + + + [(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium + RESID-alternate + + + S-methyl-L-methionine + RESID-name + + + S-methylmethionine + RESID-alternate + + + S-methylmethioninium + RESID-alternate + + + vitamin U + RESID-alternate + + + + DiffAvg + 15.03 + + + + DiffFormula + C 1 H 3 N 0 O 0 S 0 + + + + DiffMono + 15.022927 + + + + FormalCharge + 1+ + + + + Formula + C 6 H 12 N 1 O 1 S 1 + + + + MassAvg + 146.23 + + + + MassMono + 146.063411 + + + + Origin + M + + + + Source + natural + + + + TermSpec + none + + MOD:00716 + PSI-MOD + + + MOD:01975 + S-poly(3-hydroxybutyrate)-L-cysteine + + A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine. + + 19711985 + PubMed + + + 9888824 + PubMed + + + AA0617 + RESID + + + + (alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy) + RESID-systematic + + + S-poly(3-hydroxybutanoate)cysteine + RESID-alternate + + + S-poly(3-hydroxybutanoic acid)cysteine + RESID-alternate + + + S-poly(3-hydroxybutyrate)-L-cysteine + RESID-name + + + S-poly(3-hydroxybutyrate)cysteine + RESID-alternate + + + S-poly(3-hydroxybutyric acid)cysteine + RESID-alternate + + + S-poly(beta-hydroxybutyrate)cysteine + RESID-alternate + + + S-poly[(R)-3-hydroxybutyrate]cysteine + RESID-alternate + + + + DiffAvg + 172.18 + + + + DiffFormula + C 8 H 12 N 0 O 4 S 0 + + + + DiffMono + 172.073559 + + + + Formula + C 11 H 17 N 1 O 5 S 1 + + + + MassAvg + 275.32 + + + + MassMono + 275.082744 + + + + Origin + C + + + + Source + natural + + + + TermSpec + none + + MOD:00672 + MOD:00905 + PSI-MOD + + + MOD:01976 + O3-(poly-3-hydroxybutyrate)-L-serine + + A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine. + + 17659252 + PubMed + + + 20004640 + PubMed + + + AA0618 + RESID + + + PSI-MOD-slim + + (2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid + RESID-systematic + + + O3-(poly-3-hydroxybutyrate)-L-serine + RESID-name + + + O3-poly(3-hydroxybutanoate)serine + RESID-alternate + + + O3-poly(3-hydroxybutanoic acid)serine + RESID-alternate + + + O3-poly(3-hydroxybutyrate)serine + RESID-alternate + + + O3-poly(3-hydroxybutyric acid)serine + RESID-alternate + + + O3-poly(beta-hydroxybutyrate)serine + RESID-alternate + + + O3-poly[(R)-3-hydroxybutyrate]serine + RESID-alternate + + + + DiffAvg + 172.18 + + + + DiffFormula + C 8 H 12 N 0 O 4 + + + + DiffMono + 172.073559 + + + + Formula + C 11 H 17 N 1 O 6 + + + + MassAvg + 259.26 + + + + MassMono + 259.105587 + + + + Origin + S + + + + Source + natural + + + + TermSpec + none + + MOD:00671 + MOD:00916 + PSI-MOD + + + MOD:01977 + O-(L-isoglutamyl)-L-serine + + A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond to form O-(L-isoglutamyl)-L-serine. + + 17051152 + PubMed + + + AA0597 + RESID + + + Cross-link 2. + + (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid + RESID-systematic + + + O(beta)-(gamma-glutamyl)serine + RESID-alternate + + + O-(L-isoglutamyl)-L-serine + RESID-name + + + O3-(isoglutamyl)-serine + RESID-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 8 H 10 N 2 O 4 + + + + MassAvg + 198.18 + + + + MassMono + 198.064057 + + + + Origin + S, X + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:00885 + MOD:00916 + PSI-MOD + + + MOD:01978 + O-(L-isoaspartyl)-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water. + + 8706862 + PubMed + + + AA0525 + RESID + + + This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. + + (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid + RESID-alternate + + + O(beta)-(beta-aspartyl)threonine + RESID-alternate + + + O-(L-isoaspartyl)-L-threonine + RESID-name + + + O3-(isoaspartyl)-threonine + RESID-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 8 H 12 N 2 O 5 + + + + MassAvg + 216.19 + + + + MassMono + 216.074621 + + + + Origin + T, X + + + + Source + natural + + + + TermSpec + none + + MOD:00859 + MOD:00917 + PSI-MOD + + + MOD:01979 + O-(L-isoglutamyl)-L-threonine + + A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia. + + 8706862 + PubMed + + + AA0536 + RESID + + + This is not an ester cross-link of peptides [JSG]. + + (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid + RESID-systematic + + + (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid + RESID-alternate + + + 5-(threon-O3-yl)glutamate + RESID-alternate + + + O(beta)-(gamma-glutamyl)threonine + RESID-alternate + + + O-(L-isoglutamyl)-L-threonine + RESID-name + + + O3-(isoglutamyl)threonine + RESID-alternate + + + + DiffAvg + none + + + + DiffFormula + none + + + + DiffMono + none + + + + Formula + C 9 H 14 N 2 O 5 + + + + MassAvg + 230.22 + + + + MassMono + 230.090272 + + + + Origin + T, X + + + + Source + hypothetical + + + + TermSpec + none + + MOD:00859 + MOD:00917 + PSI-MOD + + + MOD:01980 + omega-N-glycosyl-L-arginine + + A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine. + + 15279557 + PubMed + + + 8521968 + PubMed + + + 9536051 + PubMed + + + AA0327 + RESID + + + 41#R + UniMod + + + + (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid + RESID-systematic + + + Hex + PSI-MS-label + + + Hexose + UniMod-description + + + NG-beta-D-glucosylarginine + RESID-alternate + + + omega-N-(beta-D-glucosyl)-L-arginine + RESID-alternate + + + omega-N-glucosyl-L-arginine + RESID-name + + + omega-N-glycosyl-L-arginine + RESID-alternate + + + + Origin + R + + + + Source + natural + + + + TermSpec + none + + MOD:00006 + MOD:00902 + PSI-MOD + + + MOD:01981 + 3-methyllanthionine + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity. + + 18688235 + PubMed + + + Cross-link 2. + + 2,6-diamino-3-methyl-4-thiaheptanedioic acid + PSI-MOD-alternate + + + 2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid + PSI-MOD-alternate + + + 2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid + PSI-MOD-alternate + + + 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid + PSI-MOD-alternate + + + 3-methyllanthionine + PSI-MOD-alternate + + + cysteine-3-L-butyrine thioether + PSI-MOD-alternate + + + + DiffAvg + -18.02 + + + + DiffFormula + C 0 H -2 N 0 O -1 S 0 + + + + DiffMono + -18.010565 + + + + Formula + C 7 H 10 N 2 O 2 S 1 + + + + MassAvg + 186.23 + + + + MassMono + 186.046299 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:00954 + MOD:01993 + PSI-MOD + + + MOD:01982 + N,N,N-trimethylglycine + + modification from RESID + + 17750 + ChEBI + + + 23818633 + PubMed + + + 23978223 + PubMed + + + AA0619 + RESID + + + PSI-MOD-slim + + (trimethylammonio)ethanoic acid + RESID-alternate + + + 1-carboxy-N,N,N-trimethylmethanazanium + RESID-alternate + + + 2-trimethylammonioacetate + RESID-alternate + + + betaine + RESID-alternate + + + carboxy-N,N,N-trimethylmethanaminium + RESID-systematic + + + carboxymethyl-trimethylazanium + RESID-alternate + + + glycine betaine + RESID-alternate + + + MOD_RES N,N,N-trimethylglycine + UniProt-feature + + + N,N,N-trimethylglycine cation + RESID-alternate + + + N,N,N-trimethylglycinium + RESID-alternate + + + N2Me3+Gly + PSI-MOD-label + + + + DiffAvg + 43.09 + + + + DiffFormula + C 3 H 7 N 0 O 0 + + + + DiffMono + 43.054775 + + + + Formula + C 5 H 11 N 1 O 1 + + + + MassAvg + 101.15 + + + + MassMono + 101.084064 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00714 + MOD:01698 + PSI-MOD + + + MOD:01983 + N,N-dimethylglycine + + A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine. + + 17724 + ChEBI + + + 23818633 + PubMed + + + 23978223 + PubMed + + + AA0620 + RESID + + + + (dimethylamino)ethanoic acid + RESID-systematic + + + 1-carboxy-N,N-dimethylaminomethane + RESID-alternate + + + 2-(dimethylamino)acetic acid + RESID-alternate + + + MOD_RES N,N-dimethylglycine + UniProt-feature + + + vitamin B16 + RESID-alternate + + + + DiffAvg + 28.05 + + + + DiffFormula + C 2 H 4 N 0 O 0 + + + + DiffMono + 28.031300 + + + + Formula + C 4 H 8 N 1 O 1 + + + + MassAvg + 86.11 + + + + MassMono + 86.060589 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00714 + MOD:01686 + PSI-MOD + + + MOD:01984 + 2-(L-cystein-S-yl)-L-alanine + + A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine. + + 21526839 + PubMed + + + AA0621 + RESID + + + Cross-link 2. + + (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid + RESID-systematic + + + (2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid + RESID-alternate + + + alpha-(L-cystein-S-yl)-L-alanine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 2 S 1 + + + + MassAvg + 172.20 + + + + MassMono + 172.030649 + + + + Origin + A, C + + + + Source + natural + + + + TermSpec + none + + MOD:00901 + MOD:01992 + PSI-MOD + + + MOD:01985 + 2-(L-cystein-S-yl)-D-asparagine + + A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine. + + 21786372 + PubMed + + + AA0622 + RESID + + + Cross-link 2. + + (2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid + RESID-systematic + + + alpha-(L-cystein-S-yl)-D-asparagine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 7 H 9 N 3 O 3 S 1 + + + + MassAvg + 215.23 + + + + MassMono + 215.036462 + + + + Origin + C, N + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00903 + MOD:01992 + PSI-MOD + + + MOD:01986 + 2-(L-cystein-S-yl)-L-serine + + A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine. + + 21526839 + PubMed + + + AA0623 + RESID + + + Cross-link 2. + + (2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid + RESID-systematic + + + (2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 3 S 1 + + + + MassAvg + 188.20 + + + + MassMono + 188.025563 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00916 + MOD:01992 + PSI-MOD + + + MOD:01987 + 2-(L-cystein-S-yl)-D-serine + + A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine. + + 21786372 + PubMed + + + AA0624 + RESID + + + Cross-link 2. + + (2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid + RESID-alternate + + + (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid + RESID-systematic + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 6 H 8 N 2 O 3 S 1 + + + + MassAvg + 188.20 + + + + MassMono + 188.025563 + + + + Origin + C, S + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00916 + MOD:01992 + PSI-MOD + + + MOD:01988 + 2-(L-cystein-S-yl)-L-threonine + + A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine. + + 21526839 + PubMed + + + AA0625 + RESID + + + Cross-link 2. + + (2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid + RESID-systematic + + + (2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid + RESID-alternate + + + alpha-(L-cystein-S-yl)-L-threonine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 7 H 10 N 2 O 3 S 1 + + + + MassAvg + 202.23 + + + + MassMono + 202.041213 + + + + Origin + C, T + + + + Source + natural + + + + TermSpec + none + + MOD:00917 + MOD:01992 + PSI-MOD + + + MOD:01989 + 2-(L-cystein-S-yl)-D-tyrosine + + A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine. + + 21526839 + PubMed + + + AA0626 + RESID + + + Cross-link 2. + + (2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid + RESID-alternate + + + (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid + RESID-systematic + + + alpha-(L-cystein-S-yl)-D-tyrosine + RESID-alternate + + + + DiffAvg + -2.02 + + + + DiffFormula + C 0 H -2 N 0 O 0 S 0 + + + + DiffMono + -2.015650 + + + + Formula + C 12 H 12 N 2 O 3 S 1 + + + + MassAvg + 264.30 + + + + MassMono + 264.056863 + + + + Origin + C, Y + + + + Source + natural + + + + TermSpec + none + + MOD:00664 + MOD:00919 + MOD:01992 + PSI-MOD + + + MOD:01990 + protonated glycine (glycinium) residue + + A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine). + + 64723 + ChEBI + + + 18688235 + PubMed + + + PSI-MOD-slim + + + DiffAvg + 1.01 + + + + DiffFormula + C 0 H 1 N 0 O 0 + + + + DiffMono + 1.007276 + + + + FormalCharge + 1+ + + + + Formula + C 2 H 5 N 1 O 1 + + + + MassAvg + 59.07 + + + + MassMono + 59.036565 + + + + Origin + G + + + + Source + natural + + + + TermSpec + N-term + + MOD:00908 + MOD:01700 + PSI-MOD + + + MOD:01991 + N,N,N-trimethylglycine (from glycinium) + + A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine. + + 17750 + ChEBI + + + 23818633 + PubMed + + + 23978223 + PubMed + + + AA0619 + RESID + + + For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Gly process (MOD:01982) accounts for both protonation and trimethylation. + PSI-MOD-slim + + N2Me3Gly + PSI-MOD-label + + + + DiffAvg + 42.08 + + + + DiffFormula + C 3 H 6 N 0 O 0 + + + + DiffMono + 42.046402 + + + + FormalCharge + 1+ + + + + Formula + C 5 H 11 N 1 O 1 + + + + MassAvg + 101.15 + + + + MassMono + 101.083515 + + + + Origin + MOD:01990 + + + + Source + natural + + + + TermSpec + N-term + + MOD:01687 + + derives_from + MOD:019900 + + PSI-MOD + + + MOD:01992 + alpha-carbon thioether crosslinked residues + + A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue. + + 18688235 + PubMed + + + MOD:00687 + PSI-MOD + + + MOD:01993 + beta-carbon thioether crosslinked residues + + A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue. + + 18688235 + PubMed + + + These are typical lanthionine-like crosslinks. + MOD:00687 + PSI-MOD + + + MOD:01994 + N1'-formyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan. + + 18688235 + PubMed + + + This modifications has not been reported as commonly encountered [JSG]. + + N1'FoTrp + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 12 H 10 N 2 O 2 + + + + MassAvg + 214.22 + + + + MassMono + 214.074228 + + + + Origin + W + + + + Source + hypothetical + + + + TermSpec + none + + MOD:01106 + PSI-MOD + + + MOD:01995 + N2-formyl-L-tryptophan + + A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan. + + 18688235 + PubMed + + + This modifications has not been reported as commonly encountered [JSG]. + + N2FoTrp + PSI-MOD-label + + + + DiffAvg + 28.01 + + + + DiffFormula + C 1 H 0 N 0 O 1 + + + + DiffMono + 27.994915 + + + + Formula + C 12 H 11 N 2 O 2 + + + + MassAvg + 215.23 + + + + MassMono + 215.082053 + + + + Origin + W + + + + Source + hypothetical + + + + TermSpec + N-term + + MOD:01106 + PSI-MOD + + + MOD:01996 + butanoylated residue + + A protein modification that effectively replaces a hydrogen atom with an butanoyl group. + + 18688235 + PubMed + + + Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). + + ButRes + PSI-MOD-label + + + Butyryl + UniMod-interim + + + butyrylation + PSI-MOD-alternate + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 O 1 + + + + DiffMono + 70.041865 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:00649 + PSI-MOD + + + MOD:01997 + N-butanoylated residue + + A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group. + + 18688235 + PubMed + + + + N-butanoyl + PSI-MOD-alternate + + + N-butanoylation + PSI-MOD-alternate + + + N-butyryl + PSI-MOD-alternate + + + N-butyrylation + PSI-MOD-alternate + + + NButRes + PSI-MOD-label + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 N 0 O 1 + + + + DiffMono + 70.041865 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + none + + + + TermSpec + none + + MOD:01996 + PSI-MOD + + + MOD:01998 + alpha-amino butanoylated residue + + A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group. + + 18688235 + PubMed + + + + N2ButRes + PSI-MOD-label + + + + DiffAvg + 70.09 + + + + DiffFormula + C 4 H 6 N 0 O 1 + + + + DiffMono + 70.041865 + + + + Formula + none + + + + MassAvg + none + + + + MassMono + none + + + + Origin + X + + + + Source + artifact + + + + TermSpec + N-term + + MOD:01997 + PSI-MOD + + + MOD:01999 + N6-(11-cis)-retinylidene-L-lysine + + A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine. + + 18688235 + PubMed + + + + (2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid + PSI-MOD-alternate + + + + DiffAvg + 266.43 + + + + DiffFormula + C 20 H 26 N 0 O 0 + + + + DiffMono + 266.203451 + + + + Formula + C 26 H 38 N 2 O 1 + + + + MassAvg + 394.60 + + + + MassMono + 394.298414 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:02000 + PSI-MOD + + + MOD:02000 + N6-retinylidene-L-lysine (unspecified geometric isomer) + + A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer). + + 18688235 + PubMed + + + + (2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid + PSI-MOD-alternate + + + + DiffAvg + 266.43 + + + + DiffFormula + C 20 H 26 N 0 O 0 + + + + DiffMono + 266.203451 + + + + Formula + C 26 H 38 N 2 O 1 + + + + MassAvg + 394.60 + + + + MassMono + 394.298414 + + + + Origin + K + + + + Source + natural + + + + TermSpec + none + + MOD:00912 + PSI-MOD + + + contains + contains + + 'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'. + + 18688235 + PubMed + + + The inverse relationship to "part of". + 1 + PSI-MOD + + + derives_from + derives from + + 'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'. + + 18688235 + PubMed + + + 1 + PSI-MOD + + + has_functional_parent + has functional parent + + 'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification. + + 18688235 + PubMed + + + This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent. + 1 + PSI-MOD + + + part_of + part of + + 'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'. + + 18688235 + PubMed + + + 1 + PSI-MOD + +
diff --git a/README.md b/README.md index 72e82a5..ebb6a49 100644 --- a/README.md +++ b/README.md @@ -1 +1,11 @@ -# psi-mod \ No newline at end of file +# PSI-MOD psidev-cvs-legacy final github repository +This repository contains the final versions of files captured by the psidev cvs repository on SourceForge + +## The PSI working group PSI-MOD +The joint activies PSI-MOD working group rests operation until further notice. +Description on the project can be found [here](http://www.psidev.info/MOD). + +## Fixing missing links +Unfortunately, SourceForge CVS, where files using PSI-MOD used to link to, ceased existence. + +The link (http://psidev.cvs.sourceforge.net/viewvc/*checkout*/psidev/psi/mod/data/psi-mod.obo) found in various files is supposed to be safely substituted with the link for the corresponding file (https://raw.githubusercontent.com/HUPO-PSI/psi-mod/master/psi-mod.obo)