From c84fb2c6dc49efd3f36ca85f58cd842971642072 Mon Sep 17 00:00:00 2001
From: Peter Robinson <peter.robinson@jax.org>
Date: Sun, 12 Jan 2025 19:29:25 +0100
Subject: [PATCH] WWOX update

---
 notebooks/WWOX/WWOX_DEE28_individuals.ipynb   |  20 ++---
 notebooks/WWOX/WWOX_SCAR12_individuals.ipynb  |  83 +++++++++---------
 .../WWOX/input/WWOX_DEE28_individuals.xlsx    | Bin 20383 -> 20411 bytes
 .../PMID_24369382_Family1II1.json             |   4 +-
 .../PMID_24369382_Family1II2.json             |   4 +-
 .../PMID_24369382_Family1II3.json             |   4 +-
 .../PMID_24369382_Family1II4.json             |   4 +-
 .../PMID_24369382_Family2II1.json             |   4 +-
 .../PMID_24369382_Family2II2.json             |   4 +-
 .../PMID_25411445_Abdel-SalametalII4.json     |   2 +-
 .../phenopackets/PMID_25411445_Patient1.json  |  10 +--
 .../phenopackets/PMID_25411445_Patient2.json  |   6 +-
 .../phenopackets/PMID_25411445_Patient3.json  |   2 +-
 .../phenopackets/PMID_25411445_Patient4.json  |   2 +-
 .../phenopackets/PMID_25411445_Patient5.json  |   6 +-
 .../phenopackets/PMID_27495153_Patient1.json  |   2 +-
 .../phenopackets/PMID_27495153_Patient2.json  |   2 +-
 .../PMID_30094525_Casereport.json             |   2 +-
 .../phenopackets/PMID_30356099_Patient1.json  |  26 ++----
 .../phenopackets/PMID_30356099_Patient10.json |   2 +-
 .../phenopackets/PMID_30356099_Patient11.json |   2 +-
 .../phenopackets/PMID_30356099_Patient12.json |   2 +-
 .../phenopackets/PMID_30356099_Patient13.json |   2 +-
 .../phenopackets/PMID_30356099_Patient14.json |   2 +-
 .../phenopackets/PMID_30356099_Patient15.json |   2 +-
 .../phenopackets/PMID_30356099_Patient16.json |   2 +-
 .../phenopackets/PMID_30356099_Patient17.json |   2 +-
 .../phenopackets/PMID_30356099_Patient18.json |   2 +-
 .../phenopackets/PMID_30356099_Patient19.json |   2 +-
 .../phenopackets/PMID_30356099_Patient2.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient20.json |   2 +-
 .../phenopackets/PMID_30356099_Patient3.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient4.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient5.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient6.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient7.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient8.json  |   2 +-
 .../phenopackets/PMID_30356099_Patient9.json  |   2 +-
 .../PMID_39101447_casepresentation.json       |   2 +-
 .../phenopackets/PMID_39416860_proband.json   |   2 +-
 .../phenopackets/PMID_39507621_patient.json   |   2 +-
 41 files changed, 109 insertions(+), 122 deletions(-)

diff --git a/notebooks/WWOX/WWOX_DEE28_individuals.ipynb b/notebooks/WWOX/WWOX_DEE28_individuals.ipynb
index e7ce40cf..b5a37746 100644
--- a/notebooks/WWOX/WWOX_DEE28_individuals.ipynb
+++ b/notebooks/WWOX/WWOX_DEE28_individuals.ipynb
@@ -10,7 +10,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 18,
+   "execution_count": 3,
    "id": "e5d196a5-0eea-4172-8e54-e1b0cbcd7d21",
    "metadata": {},
    "outputs": [
@@ -18,7 +18,7 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "Using pyphetools version 0.9.113\n"
+      "Using pyphetools version 0.9.115\n"
      ]
     }
    ],
@@ -32,7 +32,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 19,
+   "execution_count": 4,
    "id": "6fbeec2a-08f4-409a-80f7-60fe62e5c626",
    "metadata": {},
    "outputs": [],
@@ -44,7 +44,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 20,
+   "execution_count": 9,
    "id": "5a7789fc",
    "metadata": {},
    "outputs": [
@@ -60,15 +60,15 @@
     }
    ],
    "source": [
-    "dels = {\"DEL exon 1-5\" , \"DEL exon 6-8\", \"DEL 2.8 Mb\"}\n",
-    "\n",
+    "dels = {\"DEL:exon 1-5\" , \"DEL:exon 6-8\",\"DEL:2.8 Mb\"  }\n",
+    "dups = {\"DUP:exon 6-8\"}\n",
     "timporter = TemplateImporter(template=template, hp_json=hp_json, created_by=created_by)\n",
-    "individual_list, cvalidator = timporter.import_phenopackets_from_template(deletions=dels)"
+    "individual_list, cvalidator = timporter.import_phenopackets_from_template(deletions=dels, duplications=dups)"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 21,
+   "execution_count": 10,
    "id": "56ee298e-10fa-445e-8349-5ab11d8dedad",
    "metadata": {},
    "outputs": [
@@ -100,7 +100,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 22,
+   "execution_count": 11,
    "id": "5d044b78",
    "metadata": {},
    "outputs": [
@@ -368,7 +368,7 @@
    "name": "python",
    "nbconvert_exporter": "python",
    "pygments_lexer": "ipython3",
-   "version": "3.12.4"
+   "version": "3.12.8"
   }
  },
  "nbformat": 4,
diff --git a/notebooks/WWOX/WWOX_SCAR12_individuals.ipynb b/notebooks/WWOX/WWOX_SCAR12_individuals.ipynb
index 46d9179b..2ad72b21 100644
--- a/notebooks/WWOX/WWOX_SCAR12_individuals.ipynb
+++ b/notebooks/WWOX/WWOX_SCAR12_individuals.ipynb
@@ -11,7 +11,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 7,
+   "execution_count": 1,
    "id": "ec2afcb4-cf50-40fe-b4f0-9c1f878b6aa2",
    "metadata": {},
    "outputs": [
@@ -19,7 +19,7 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "Using pyphetools version 0.9.113\n"
+      "Using pyphetools version 0.9.115\n"
      ]
     }
    ],
@@ -33,19 +33,18 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 8,
+   "execution_count": 2,
    "id": "70c1eb70-61a8-4d38-aa13-0c457f3523d7",
    "metadata": {},
    "outputs": [],
    "source": [
     "template = \"input/WWOX_SCAR12_individuals.xlsx\"\n",
-    "hp_json = \"../hp.json\"\n",
     "created_by = \"0000-0002-0736-9199\""
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 9,
+   "execution_count": 3,
    "id": "5a7789fc",
    "metadata": {},
    "outputs": [
@@ -53,7 +52,7 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "HPO version 2024-08-13\n",
+      "HPO version 2024-12-12\n",
       "Created encoders for 29 fields\n",
       "Importing OMIM:614322, Spinocerebellar ataxia, autosomal recessive 12, HGNC:12799, WWOX,  NM_016373.2\n",
       "We output 6 GA4GH phenopackets to the directory phenopackets\n"
@@ -61,13 +60,13 @@
     }
    ],
    "source": [
-    "timporter = TemplateImporter(template=template, hp_json=hp_json, created_by=created_by)\n",
+    "timporter = TemplateImporter(template=template, created_by=created_by)\n",
     "individual_list, cvalidator = timporter.import_phenopackets_from_template()"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 10,
+   "execution_count": 4,
    "id": "f17c3924",
    "metadata": {},
    "outputs": [
@@ -98,7 +97,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 11,
+   "execution_count": 5,
    "id": "fd367ed6",
    "metadata": {},
    "outputs": [
@@ -131,7 +130,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 12,
+   "execution_count": 6,
    "id": "23f1094f",
    "metadata": {},
    "outputs": [
@@ -201,7 +200,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -218,7 +217,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
@@ -235,7 +234,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>3</th>\n",
@@ -252,7 +251,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>4</th>\n",
@@ -269,7 +268,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>5</th>\n",
@@ -286,7 +285,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>6</th>\n",
@@ -303,7 +302,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>7</th>\n",
@@ -320,7 +319,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>8</th>\n",
@@ -337,7 +336,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>9</th>\n",
@@ -354,7 +353,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>10</th>\n",
@@ -371,7 +370,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>11</th>\n",
@@ -388,7 +387,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>12</th>\n",
@@ -405,7 +404,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>13</th>\n",
@@ -422,7 +421,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>14</th>\n",
@@ -439,7 +438,7 @@
        "      <td></td>\n",
        "      <td>PMID:24369382</td>\n",
        "      <td>PCS</td>\n",
-       "      <td>ORCID:0000-0002-0736-9199[2024-11-12]</td>\n",
+       "      <td>ORCID:0000-0002-0736-9199[2025-01-12]</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -498,24 +497,24 @@
        "14                       PMID:24369382      PCS   \n",
        "\n",
        "                              biocuration  \n",
-       "0   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "1   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "2   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "3   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "4   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "5   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "6   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "7   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "8   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "9   ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "10  ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "11  ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "12  ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "13  ORCID:0000-0002-0736-9199[2024-11-12]  \n",
-       "14  ORCID:0000-0002-0736-9199[2024-11-12]  "
+       "0   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "1   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "2   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "3   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "4   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "5   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "6   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "7   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "8   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "9   ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "10  ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "11  ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "12  ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "13  ORCID:0000-0002-0736-9199[2025-01-12]  \n",
+       "14  ORCID:0000-0002-0736-9199[2025-01-12]  "
       ]
      },
-     "execution_count": 12,
+     "execution_count": 6,
      "metadata": {},
      "output_type": "execute_result"
     }
@@ -550,7 +549,7 @@
    "name": "python",
    "nbconvert_exporter": "python",
    "pygments_lexer": "ipython3",
-   "version": "3.12.4"
+   "version": "3.12.8"
   }
  },
  "nbformat": 4,
diff --git a/notebooks/WWOX/input/WWOX_DEE28_individuals.xlsx b/notebooks/WWOX/input/WWOX_DEE28_individuals.xlsx
index a0c0035099ffda7674248798d0f0673cbcd52462..2ccf2c7b5fb229bf8f9669506a318fa0c2f13106 100644
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diff --git a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II1.json b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II1.json
index b06dd75f..a970d1ff 100644
--- a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II1.json
+++ b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II1.json
@@ -130,7 +130,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:04:44.274138927Z",
+    "created": "2025-01-12T18:26:19.503175020Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
@@ -169,7 +169,7 @@
         "id": "hp",
         "name": "human phenotype ontology",
         "url": "http://purl.obolibrary.org/obo/hp.owl",
-        "version": "2024-08-13",
+        "version": "2024-12-12",
         "namespacePrefix": "HP",
         "iriPrefix": "http://purl.obolibrary.org/obo/HP_"
       }
diff --git a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II2.json b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II2.json
index d5b922bf..6551a8b4 100644
--- a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II2.json
+++ b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II2.json
@@ -136,7 +136,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:04:44.274778127Z",
+    "created": "2025-01-12T18:26:19.504307985Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
@@ -175,7 +175,7 @@
         "id": "hp",
         "name": "human phenotype ontology",
         "url": "http://purl.obolibrary.org/obo/hp.owl",
-        "version": "2024-08-13",
+        "version": "2024-12-12",
         "namespacePrefix": "HP",
         "iriPrefix": "http://purl.obolibrary.org/obo/HP_"
       }
diff --git a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II3.json b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II3.json
index f6029a3c..7c31099a 100644
--- a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II3.json
+++ b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II3.json
@@ -136,7 +136,7 @@
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   ],
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-    "created": "2024-11-12T08:04:44.275202035Z",
+    "created": "2025-01-12T18:26:19.504781007Z",
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     "resources": [
       {
@@ -175,7 +175,7 @@
         "id": "hp",
         "name": "human phenotype ontology",
         "url": "http://purl.obolibrary.org/obo/hp.owl",
-        "version": "2024-08-13",
+        "version": "2024-12-12",
         "namespacePrefix": "HP",
         "iriPrefix": "http://purl.obolibrary.org/obo/HP_"
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diff --git a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II4.json b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II4.json
index 6add2e5b..a41477ff 100644
--- a/notebooks/WWOX/phenopackets/PMID_24369382_Family1II4.json
+++ b/notebooks/WWOX/phenopackets/PMID_24369382_Family1II4.json
@@ -123,7 +123,7 @@
     }
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-    "created": "2024-11-12T08:04:44.275619983Z",
+    "created": "2025-01-12T18:26:19.505357980Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
@@ -162,7 +162,7 @@
         "id": "hp",
         "name": "human phenotype ontology",
         "url": "http://purl.obolibrary.org/obo/hp.owl",
-        "version": "2024-08-13",
+        "version": "2024-12-12",
         "namespacePrefix": "HP",
         "iriPrefix": "http://purl.obolibrary.org/obo/HP_"
       }
diff --git a/notebooks/WWOX/phenopackets/PMID_24369382_Family2II1.json b/notebooks/WWOX/phenopackets/PMID_24369382_Family2II1.json
index 232615d4..106ec0fa 100644
--- a/notebooks/WWOX/phenopackets/PMID_24369382_Family2II1.json
+++ b/notebooks/WWOX/phenopackets/PMID_24369382_Family2II1.json
@@ -118,7 +118,7 @@
     }
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   "metaData": {
-    "created": "2024-11-12T08:04:44.276021003Z",
+    "created": "2025-01-12T18:26:19.505725860Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
@@ -157,7 +157,7 @@
         "id": "hp",
         "name": "human phenotype ontology",
         "url": "http://purl.obolibrary.org/obo/hp.owl",
-        "version": "2024-08-13",
+        "version": "2024-12-12",
         "namespacePrefix": "HP",
         "iriPrefix": "http://purl.obolibrary.org/obo/HP_"
       }
diff --git a/notebooks/WWOX/phenopackets/PMID_24369382_Family2II2.json b/notebooks/WWOX/phenopackets/PMID_24369382_Family2II2.json
index e9091fb0..be594e0d 100644
--- a/notebooks/WWOX/phenopackets/PMID_24369382_Family2II2.json
+++ b/notebooks/WWOX/phenopackets/PMID_24369382_Family2II2.json
@@ -118,7 +118,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:04:44.276421070Z",
+    "created": "2025-01-12T18:26:19.506075859Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
@@ -157,7 +157,7 @@
         "id": "hp",
         "name": "human phenotype ontology",
         "url": "http://purl.obolibrary.org/obo/hp.owl",
-        "version": "2024-08-13",
+        "version": "2024-12-12",
         "namespacePrefix": "HP",
         "iriPrefix": "http://purl.obolibrary.org/obo/HP_"
       }
diff --git a/notebooks/WWOX/phenopackets/PMID_25411445_Abdel-SalametalII4.json b/notebooks/WWOX/phenopackets/PMID_25411445_Abdel-SalametalII4.json
index 64eacebe..50c6937c 100644
--- a/notebooks/WWOX/phenopackets/PMID_25411445_Abdel-SalametalII4.json
+++ b/notebooks/WWOX/phenopackets/PMID_25411445_Abdel-SalametalII4.json
@@ -207,7 +207,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.209033966Z",
+    "created": "2025-01-12T18:25:29.418869972Z",
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     "resources": [
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diff --git a/notebooks/WWOX/phenopackets/PMID_25411445_Patient1.json b/notebooks/WWOX/phenopackets/PMID_25411445_Patient1.json
index 29b7ae9a..622ed698 100644
--- a/notebooks/WWOX/phenopackets/PMID_25411445_Patient1.json
+++ b/notebooks/WWOX/phenopackets/PMID_25411445_Patient1.json
@@ -195,8 +195,8 @@
             "interpretationStatus": "CAUSATIVE",
             "variantInterpretation": {
               "variationDescriptor": {
-                "id": "var_mJMAkuNOpJsrfeYwUNIaezNqD",
-                "label": "DEL exon 1-5",
+                "id": "var_kHkfLpHZUeywqnJxAVJAJeUUv",
+                "label": "DEL:exon 1-5",
                 "geneContext": {
                   "valueId": "HGNC:12799",
                   "symbol": "WWOX"
@@ -218,8 +218,8 @@
             "interpretationStatus": "CAUSATIVE",
             "variantInterpretation": {
               "variationDescriptor": {
-                "id": "var_bfElexTqfwlLnSsYlZvfDrurc",
-                "label": "DEL exon 6-8",
+                "id": "var_MLAUYfPYkVqCEKCsPcOpDEhVZ",
+                "label": "DEL:exon 6-8",
                 "geneContext": {
                   "valueId": "HGNC:12799",
                   "symbol": "WWOX"
@@ -255,7 +255,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.205399036Z",
+    "created": "2025-01-12T18:25:29.413248062Z",
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     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_25411445_Patient2.json b/notebooks/WWOX/phenopackets/PMID_25411445_Patient2.json
index 56ca404b..dd283ffb 100644
--- a/notebooks/WWOX/phenopackets/PMID_25411445_Patient2.json
+++ b/notebooks/WWOX/phenopackets/PMID_25411445_Patient2.json
@@ -224,8 +224,8 @@
             "interpretationStatus": "CAUSATIVE",
             "variantInterpretation": {
               "variationDescriptor": {
-                "id": "var_bfElexTqfwlLnSsYlZvfDrurc",
-                "label": "DEL exon 6-8",
+                "id": "var_MLAUYfPYkVqCEKCsPcOpDEhVZ",
+                "label": "DEL:exon 6-8",
                 "geneContext": {
                   "valueId": "HGNC:12799",
                   "symbol": "WWOX"
@@ -261,7 +261,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.206474065Z",
+    "created": "2025-01-12T18:25:29.415887117Z",
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     "resources": [
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diff --git a/notebooks/WWOX/phenopackets/PMID_25411445_Patient3.json b/notebooks/WWOX/phenopackets/PMID_25411445_Patient3.json
index 2a752f1d..54364500 100644
--- a/notebooks/WWOX/phenopackets/PMID_25411445_Patient3.json
+++ b/notebooks/WWOX/phenopackets/PMID_25411445_Patient3.json
@@ -288,7 +288,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.207162141Z",
+    "created": "2025-01-12T18:25:29.416551828Z",
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diff --git a/notebooks/WWOX/phenopackets/PMID_25411445_Patient4.json b/notebooks/WWOX/phenopackets/PMID_25411445_Patient4.json
index 2b079e70..66ca4058 100644
--- a/notebooks/WWOX/phenopackets/PMID_25411445_Patient4.json
+++ b/notebooks/WWOX/phenopackets/PMID_25411445_Patient4.json
@@ -288,7 +288,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.207850933Z",
+    "created": "2025-01-12T18:25:29.417551040Z",
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diff --git a/notebooks/WWOX/phenopackets/PMID_25411445_Patient5.json b/notebooks/WWOX/phenopackets/PMID_25411445_Patient5.json
index 8f079e5f..535fcb42 100644
--- a/notebooks/WWOX/phenopackets/PMID_25411445_Patient5.json
+++ b/notebooks/WWOX/phenopackets/PMID_25411445_Patient5.json
@@ -236,8 +236,8 @@
             "interpretationStatus": "CAUSATIVE",
             "variantInterpretation": {
               "variationDescriptor": {
-                "id": "var_LAotjvUxmjfvlcsPBVgFMyQVE",
-                "label": "DEL 2.8\u2005Mb",
+                "id": "var_PSkqnfQMJKkQTEYWVNLTOgWiV",
+                "label": "DEL:2.8\u2005Mb",
                 "geneContext": {
                   "valueId": "HGNC:12799",
                   "symbol": "WWOX"
@@ -273,7 +273,7 @@
     }
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   "metaData": {
-    "created": "2024-11-12T08:05:52.208437919Z",
+    "created": "2025-01-12T18:25:29.418240070Z",
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diff --git a/notebooks/WWOX/phenopackets/PMID_27495153_Patient1.json b/notebooks/WWOX/phenopackets/PMID_27495153_Patient1.json
index 7fe96ddf..184cc361 100644
--- a/notebooks/WWOX/phenopackets/PMID_27495153_Patient1.json
+++ b/notebooks/WWOX/phenopackets/PMID_27495153_Patient1.json
@@ -278,7 +278,7 @@
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   "metaData": {
-    "created": "2024-11-12T08:05:52.223991155Z",
+    "created": "2025-01-12T18:25:29.436026096Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_27495153_Patient2.json b/notebooks/WWOX/phenopackets/PMID_27495153_Patient2.json
index 25b8d619..8853fed9 100644
--- a/notebooks/WWOX/phenopackets/PMID_27495153_Patient2.json
+++ b/notebooks/WWOX/phenopackets/PMID_27495153_Patient2.json
@@ -187,7 +187,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.224673986Z",
+    "created": "2025-01-12T18:25:29.436750173Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_30094525_Casereport.json b/notebooks/WWOX/phenopackets/PMID_30094525_Casereport.json
index 645277f3..77e4cd30 100644
--- a/notebooks/WWOX/phenopackets/PMID_30094525_Casereport.json
+++ b/notebooks/WWOX/phenopackets/PMID_30094525_Casereport.json
@@ -142,7 +142,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.226836919Z",
+    "created": "2025-01-12T18:25:29.438565969Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_30356099_Patient1.json b/notebooks/WWOX/phenopackets/PMID_30356099_Patient1.json
index daf49a7d..376fbfdb 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient1.json
+++ b/notebooks/WWOX/phenopackets/PMID_30356099_Patient1.json
@@ -228,29 +228,17 @@
             "interpretationStatus": "CAUSATIVE",
             "variantInterpretation": {
               "variationDescriptor": {
-                "id": "var_MdbmQGTvLcNPpTZHJBXLzcYzJ",
+                "id": "var_mZraekLrcIGnpMocfZVuiaryO",
+                "label": "DUP:exon 6-8",
                 "geneContext": {
                   "valueId": "HGNC:12799",
                   "symbol": "WWOX"
                 },
-                "expressions": [
-                  {
-                    "syntax": "hgvs.c",
-                    "value": "NM_016373.4:c.517_1056dup"
-                  },
-                  {
-                    "syntax": "hgvs.g",
-                    "value": "NC_000016.10:g.78386860_78432752dup"
-                  }
-                ],
-                "vcfRecord": {
-                  "genomeAssembly": "hg38",
-                  "chrom": "chr16",
-                  "pos": "78386858",
-                  "ref": "A",
-                  "alt": "AGCATAAAGCCAAGGTAGAAGCAATGACCCTGGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGTGAGTGTTCCAGTGGAGGGTTATAGATCATAATTTCTTGCTATTGTAATATCTTTATCAGATGAACACAATTGGGAGAATGCAAGGCTGTTGTGTTGTCTTGGCGTCCAAACAGGAGGCTCATTTATATTGGCCCTGTTAAGGTGAACCGTATTTTCTTGACTCACAGTCACCTTCATTATGAGATGTGTCATCAATCTAATAACAGCTTCCCACATACCAAAAGAGAAGACACTATTAAAGCACTAGTAAAAGTGGCTAATAAAAGCTTGGCAATAGTAAGATGCATCCTGATTATAAGATTTTTTGTAGTGCATTTCAGAATGGAGTAAGAGTATATTTAAATTGCATTCAGGAACAAGTAAACTCAGTTATCCAGTATGGCAGGGAGGTTGACAATCCAAGCACCCAAAAGACCTCTAGTTTCTAAAGCCTTCGATGATTTGATGTGGTACATGGATGTGGTTCCAAAAAACATGGACTCACATTCCTTTTATTTATTTTTTTTCATCCTTTTCAGTCTTTCAAAATTCCAGTTGGAGAAAGCCTTAGTTAGGGCCTAGCATATTTTGATCCTATCATATGCTAGCATCCCTTTCTAACAGAGAAGGTTGTAGGAGAAAGGGAGAGAAGCGGAAGGGGGTGGGGAGACAGAGAGACAGACAGGAGGCCTCAAACCCTGAAACACTGAGCTAAGGAAAGTGATCATGGCAAGCTACACTAATTACAATACTTTGTTTCCAAGTGTTTATTTTTACTCATATTTAGGGCAGGCAATCCTGGTTTCTCGTTGAACATAGAGGTTTGAATTTCATTAATAAATAACTTCATTTATTTTTTTTCAGTGACTTGATTCAAACATGAGGATTAAGTTAATAATAGCACAGGTTGTGCGAAGGATAAGATAATTACACAAGAGGCACCAGAACCACTGAATGTGGAGAGCTCTCATAAATGACAAGCTGCCTTTGGGTTAGGCTCTGTTGGGAACATTAGTTCTGCAGTGTTGCAAGCAGATGAAGGATGTGAGGGAAGGGATCTTAAACCAGATATTCAAATGGCCCTGTGGGGAGCTGACACCACACTGCTGTCTAGTGTCCAATTCTCCTTGCATGGCTGTGTCACCCAGGTTGGAACGTAGTGCACAATCTCGCCTTAATGCAACGTCCCACTGTGGGCCCAAGTGATTTTCCTGTCCCAGCCTCCTGAGTAGCTGGGACTACAGATGCCTGCCACCATGGCCTGCTAATTTTTGTATTTTTAGTAGACATAGGGTTTCACCATATTGGTCAGACTGGTCTCAAACTCCTGGCCTCAGGTGATCCACCCGCCTCAGCCTCTGAAAATGCTGGGATTACACACATGAACCACTGCGCCCAGCCGCTCTACTTTATTAGATTTAAAAAGTTTGCTCTCAGCTGGGTGCAGTGGCTTATGCCTGTAATCCCAGCAGTTTGGGAGGCCAAGGCGGGGAGGGTCATGAGGTCAAGAGATCAAGACCATCCTGGCCAACATTGTGAAACCCCATCTCTACTAAAGATACAAAAAATTAGCTGGGTGTAGTGGTGCACACCTCTAGTCCTAGCTACTTGGGAGGCTGAGGCAGGAAAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATGGCACCACTGCACTCCAGCCTGGCGACAGATTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTTTGTACTCAGCCTGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGTGAGGCCGAGGTGGGCGGATCACCTGAAGTCAGGAGTTCGAGACCAGCCTGGGCAACAAGGTAAAACCCCGTCTCTACTAAAAATGCAAAATTAACTGGGCGGGGAGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCTGAGACTGAACCAGTGCACTCCAGCCCGGGTGACAAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAATTGACTCAGGCTCTTGCTGGAGTATGTCAGTGTCCCAAGTCACTGAGGTCTACATTAGAGTCAGTCTTAGTGAGAGTTGCAACATCGCCTAAGCGCAGACCCCAAGCTGGCTTGTAGGAACAGTGAGATAACATCCCCCAGCCAGCCAGATCTGAGAGAGCCCTCCTGTGTGTGTCCTTTGCAGCGCTTGGCTGTTAGTAGCTTCCACCCTTTGCCAGAACTATCAAGAGGCACCTCAACAGGCTGCAACACTAGCATTCAAGACATTTGTTCGCTGATTTGCTTCGTCATTCATTTATCCACCCGTTCCTTCACTTCACACACATTTCAGGAGCACCTCTAAAGCCCCAGACATTCTTCTGGGCTCTGAGAAGAGAGTGGTGGCCCTGGAAGCCACAGTAACCGCACACAAGCTGTCACCTCAGTTGTCAGCTATTATGGATGGCTGACTCCTCAAACTCATCTGTCTGTGGTTGTTTGGGAGGGAATGATAATGACAAGAACAGCAGCGGAGTCAGCAGCTCATTTACTGAGGGCTTATGGGCCATACGTGGAAAATATTTTGCATGTATGTTTTGATTCAATTCTCAAAGCAGTCCTTGGGAGTAGATGCTATTAATATCTCTACTATACAGATAAGGAAAGTGAGGCTAGAGAGGATATATAATTTATCCAAGGCATGTGGAATGTGGGTAGAGGGGCCGATTTAGCCTCTTCACGGCTCCAACTTGACCACCGTACTATACTGTGTTTCATTTTAGTTTATTTTTTATTTATTTTTTGAGACAGGGTCTCGCTGTGTTGCCCAGGCTGAAGTGCAGTGGTGCAATCTCTGTTCATTGCAACCTCTGGCCTTGGGTTCAAGCGATTCTCATGCCTCATCCTCCAGAGTAGCTGGGATTACAGGTGCAGGTTACCACACACAGCTAATTTTTGTATTTTCTGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTAGTCAACTCCTGACCTCAAGTGATCTCTCCACCTTGGCCTCCCAAACTGCTGGAATTACAGGCGTGAGCCACCCTGCCCGACCCTTTCATTTTAAATGTGATAGAAACAGACTCAGAGAATGTGAGTGACTTTCGCAGGGTCACTTAGCAGGTTGGTGACGGGCATGGGGTTTCACTCCAGTCTGCCTCTTGTTCTTTTCCTCATAGCATGTGAGATCTCACAATTCACTGCCGCTGAATAACTTTGTCCAGTTCCTCTGTCAGAATGTGTTGGAAGTGAGCAGCTTTGCTGAAGAGAGCCAACTGTTACATAATAGGATCATCTTCCACGTCTTAACTGGACCATTAGTTTTTAACCATTAAGTAGTTGGGAAATCATCAAGTTCAAGTGCCTTTTGTAATCACCAAGCTCAAAACCTTGGAGGAAACTCTCACCCATTTTGCCCTAATCCCAGATTTTAGCACAGGACTTTGGAATTTTAGAAAGTACTTCTAGGTTGAGAAACAAGGGTGATTTTCCATATAGAGACCTCTGTAGCACAACCCTCTTTGTATGTGTCCCATGAGAGTACAGGATTTTACATGGCTTAGAGAAATACTGTGGTGGTGAAAATATGCATAAAAAAGCGAGAGATTTTACTTTTGAAATGCTGCCAAAGTGAAATCTCTCTTGGATAGGCAGATGACAGTTTAGTACTTGCAGGTCTTTCGATTCTGACAACTGTCAGAAGTGAATTTAAGTGCTGGTGACTAGGCTGCCAGAGAAACACATGTAACTCTATTCTTATCACCCCCCATCTTCAGACATTAAAATTTTCTTGTGTGTAAAACATAATGACAAATGAAAGAAAGGCTGCCAGTTCAGAACCAATCTCTTTTCACGCTGTTGCATTGAGGAGAGGAAAAAATCCCTTAAATTTGAATTCCATGTGGATGCTCTTATTTAATATGCCGTTTCAAAGCCTGTATGTGATCAAGCCAGAGTATTATCAGGCTCTGAGTTCCTGTGTGTATTCCCTTGGTCCATGCTCCATCTCAAGTGTTTCTCCACACTGGGATAGGCAGCATATTGTGTAGTCTTAGAGCAGAAAAGGTAGAAACAGATTCTTAGTACAAACACTGGTGAGAAAAGCAGCATATTGTACTGTGGAACCACCCGCCGTCTGCCTTCTGTGGGAGATGGGGATCAGCCTCTTCCTGGATCTCTTCTTTTTATTCGGGTGCTGGGAGGTGAGGCTGCAAAGGAGGCTGTTGTAGAGGGAGCCCTCCTAACCATGATTATGTAAACAATAGCTGCTAGGCAACTTGTTGTTTGTTTTATGCAAGGCAGTGTGCTAAGCACTTACATACATGTATTCTGTCTGTAGTTTGTTATAAGAGTCCTGCACACTTAACCATGATTATCCCTACTTTGCAAATTACAAGGTTGCAGTGCAGAGAGCCTAAGACACTTTCTCAACTTGAGCAAGTAGGAGATCCAGAATTTGAACCCAAATCTCTCTGAATCCAAAACGACTTTTTGTTACTTTGCACACTTCAGTCATAGGAATTTCAGTGTGGATTTCTGTATTGGTTATGTATTGCCGAGTAAGAAATGACTCTGGCCAGGCACGGTGGCTCACACATGTAATCCCAGCACCTGGGGAGGCCGCAGTGGGTGGATTGCTTGAGGCCAGGAGTTTGAGAACAGCCTGGCCAACATGGCAAAACCCCGTCTGTACTAAAAATACAAAAATTAGCCGGGCATGGTGATGCATACCTGAAGTCCCAGCTACTCAGGAGGCTGAGGCATGAGAATTGCTTGAGCTCTGGGGTGGGCAGAGGTTGCAGTGAGCCGAGATCATGCCTGGGGGACAGTGAGACTCTGTCTCAAACAAATTACTCCAAAATTTAGTGGCTAAAAAACAACGTAAAACAAGAAACATTTCTTTTGTGCCTCCTCTTTTCCTCCCTCCCTCTTTCTCATAGTTAATTTGTTTGAATCAGGATTCAAATAAGGTCGATGCATTTTTAATCTATAGGTTTTGTCTCCTTTTTTTTTTTTTCCTTAAAAAAATTTCTTTTAATGCAACAGATTTAAGGGACCAGGGTGTTCTCTAGAGCAGGGGTCCATGACCTCTAGGCCACAAACCAATAGCGGAGCCGTGGCCTGTTATAAATTGGGTGGCATGGCAGGGAGTGAGTGGTGGGCAAGCATAGGAAGCTGCGTCTGTGCTTAGAGCCGCTCTCTGTCACTCTCATTAGTGCCTCAGGTCCTCCCCCTGTCAGATCAGCAACAGCATTAGTCTCATAGGACCGTGATCCCTATTGTGAGCCACACATGCAAGGGATCTAGGCTGCATGCTCCTTACGAAAATCTAATGCCTGATGATCTGTCACTGCCTCCCATCACCTTCAAGATGGGATTGTCTAGTTCTAGGAAAACAAGCTCAGGGCTCCCACCGATTGTACATTATGGTGAGTTGGATAACTATTTCATTATATATTACAACGTAATAATAATAGAAATAAAGTGCACAATAAATGTCATCTGCTTGAATCGTCCCAAAGCCACCCCCACTCCTTTGAGTCTATGGAAAAATTGTCTTCCAGAAAACCACTTGCTGGTGCCAAAAAAATTTGGAAACCTCTGCTCTAGAGATTTCTGCAGTCTGTACTTTGGTGATTGCATCTCTGTGGTGTCTTTTAACATACTCTTCTGTCTCCTGAGTTTCCTGTGAAAGGGTAGATAACTCAAGAGACTCAATCAACTTCGTGTTTAATGTTTTCGTAAGAATACTTCAGAGGCAGTGGTGTAATCGTCCAAGAGTACACACAGGCCTGATTGCCAAAGCCAGTTTTCTTCAGGCCCAGCACGTCCTGACCTCCTCACTCCTCTGCCCACTCTCTGTTTACTCACTCCCATTTTCATTCATTGATTCTGTTATTCTCCACTAAGTTTTCTGGGTGGTCAGCCCAGGAAGCCTCAGCCTGCTTCCAGATAGTTCTCCTCAGAGTTAGCGGTAGCAGCGGTCGTCGGCCAGTGTGTCTCGGGTCAAATTATTTTGGGCATTACTGGAAAGTTCCAAACCAAAGCCTGTGGTAAGTTCCACCCAAACTGGCTTGTGAGGGATATTTTTGTTTAAACTGCATTCCTGGAGAGGAGCCAGACTTCCTACTGCCTGGCAGCAGTGGTGTCCATAGGAGTATGAAGAGCTGGGACCCTTTCTAATCACTCAGACCAAATATTGGGGTTTTCTGAAATGGACTGAGAAATAACAGTATGTTTTTATGAGGCTTTGCACATTTTCCTTCCTAGCAGTAGCTGCTTAGTCTACTGAAAAGTGCATATTTTGAACAGGGCCTAGAAGAGTTAACAGCTCCTAGAGAGAGGTGCTCTGTAATACTTTTTCTTCTTCAAAAAATGGTTTATGGCTGGGCGCAATGGTTCATGCCTATAATCCCAGCGCTTTTGGGAGGCCAAGGTGAGAGGATTGCTTAAGCCCAGAAACGTGAGACCAGCCTGGGCAACGTAGTGAGACGCTGTCTCTATATTACAAAATTTTTTAAAAAACGGTTTGTAGGTCCTTAAGTCCCTGATAAAATAGAGAACTGAATTGCAATCCTGGAACTTAAAAAGTTGGTGACGACACCTGAGATATTTATTACTTAGATTGCAGTTACTGGTCAGCTTGTATAATACTGACCAAGGGTTTTGATTCTTCCTGGAATTGATAGGAAATTCATATTAAAATAATTACCCAAGTCCAAACATTTTTAGAACTGCATTTTTGATCATGGATTTTTATGTCTCTTCTGAACTTTCTGTCACCGGTATAATTTAAAGAAATTATACTTAAGCTTTGTCTCACTTAGAAGATAATATAGAACAGTGGTGTTTTTTTAATTAAAAAAAAGGTTAAAATAACGGTTTTGTATCCTTGCTTTACTTCTTAAACATATGGGAGGAAAAAAAATCTTTAACAAGTTTATTTATTTTCATTTTCTGCTAAATTACTTTCAGAACTTGAATCTACTAATCCCAGATATAATATTCTTGGATTCATATTCCAAATTTTGCTGTCTCAAATCCATCTAGGGAAGTGGGTGGGCTATAAATTATAAATAAATTCCAAATTTTGTGGGATGAATTACCCTGAAGACCAACGTGTAAATTACATATTAATCTTTCTTTTTCTCCCTAGCTCGGTTTTAAGAATAATGTTTTAGCCAACATATCTGCATTACTCTTGGCTCAATATGAGAAATCCATTTTTGGTTTGCCTAACAGAAGATCATCTTGCTTTGCTTCTCTACACAGTATGAAAACCCAAAGAAAAGAAAAACAGAGGCAGTTTTTTGCTCTAATGAATGCTCTAAATCTAGCTCTTAATTATGATTTTTTAAGGAAAATTTTGAAAAGTCTACAAGTTAAATTTTTTTTTCTATCCCATACATTTTCCATCCTAAGGCATTGAAAAAGCACACTGTGAAATACTTAGTGTATCTAGAAACATCAGGGAAGAATGCTTCCCTCCTAAGCAAAATTTTGCCTTCTGAAACTTTTTCAGCATTCAGTCTTTTTATATAATACTTAGAAAAATATTTCTGAAATAGATCATACACTCTCTTCCCAAAAACATCAAAGTATGACCGTAAAGGGCAGAGGTAGGTAAACTTCTTGTAAGGGGCCAGAGAGTGAATATTTGAGAATTTTCAGACTATTAAGATCTCTGTTGCAACTGCTTGCTTTTGCCGTGGTAGCCTGAAAGCAGCCATAGATAGTATGGAAATGGATGATCATGGCAGTGTTGCAATAAAACTTTACAAAACAGACAATGGGCCAGATTGGCCAGGGGCCATAGTATGCTACCCCTGGGCAACAACCTGTATGCCCTGGAGTAGTGTAAAGAACGTGGGTGTTGGGGGTCAACTGACGCTTCCAGCTCTACCACTTACTGGCTGTGTGGCTTTGGGCAAACTACTGAAAATCTCTCAGCGTCACTTTCCAAGTGTGTGTAATGTGTATTTTCACAGTGCTTTGCAGGTTGTTGATTATTGAAAATAGCCATAATGCATGAAATTACCAGACACATCTCACTTTATGGAGCCTGGGGCTATTGGTAATATGCATTTCTTTCTCATCTTGATCGTAAAATGATCTTAGAAAGGTTTCTGAGAATATATAGAGTTTAAGACAGCAATAAGACAACTAATTAATTAAACAGGAAAAGGGGATGTTGTGCTCAGAGAGGAAGTGTGGGTCTCATAAGGGCTTTCACAATCGTTTGAGAGGACACGTGTGATGTCTCATGCCTGTTATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGGTTGCTTGAGTTCCGGAGTTTGAGACCAGCCTCGGTAATTTGGCAAAACCTTGTCTCTACAAAAATTACAGAAATTAGTTGGGTGTGGTGGTGCACACCTGTAGTCCCAGCTGCTTGGGAGGCTGACGAGTAAGGATCACTTGAGCCAGCATGGTGGAGGCTGCCATGATCATGCTACTGCACTCCAGCCTGGGCAACAGAGCCAGAACCTGTCTTGTAAAGAAAAGGAAAAAGAGAGAGAAGGGCAGAAAGAAAGAAGGGAAGGAAGAAAGGAAAATTGGGCCCAGGAATGATCTTTACAATGCCTGACAACCAAGAGAAGAAGGGAAATGAGCTTCACATTGCCTGCAAGCTCTAGGGTGACAAGAGCCAAGAGAAATTATTGTTACTGTAGTGATGTTCCACTGAGGATCATAAAGTACTTTATTACTCTACTGAGTATGGTTTTTTGTTTTGTTTTTTCTTTTTCTTTTTCTTTTTCTTTTTTGCTATTCTTTTGTTATTCTTGATTTATGCTGATGGAAAGCCATGGACCCAAGGATGCTTCACAGTTTTCTTTCGGAGTAAATGCTTAGATTCCATTTTCTTTGACATGACTATGTCTGTTCCTCTTGATTTTAGGCATCTTTTTCAGATGAGTTGCCATAAAAGCAGCCTGCTCTGGATAAGTGAGGTACAGCAGGACACACTGCAAATACTAGGAATCCTTAAGTACAGTGGAACCCCAGAGCACTCTACCTGCTTTCTTTCTCACCTCCTTAAAAACTTTTTTTGCCCTCACCTCATCATTTATTCAGCAGTCACAACAGTGCCAAGAACTTGGCTAGAGATTGGAAATAAAGCTTATGCCTTCTCTCATATCTCCTGTACCTTATTTCTTTCTTACAGTAGTTGTGATGCTTAGCAGTTTTTTGATAACTTTTTATGATGCCAACCTTCAAAAACCTGCCCCTGGTGGAGAGAATAATTATTACATCAATTAGGGGTCACTTAGCATGACATTTGTCGGAAAAAAAAAAGTTAGTGAGCCTTTTTGCCATATTAAAAGTCATCACTGCCAAGACATAAATGAAAATGTGTTCGAATTAACCACACCAATGTTCACAAAATAAACATTTTTGATTTCCCAACAGAATCCTAGGTTTAACTATCACTATCATCTTTCATGAAATCAAAGTCATATATGTAAATTGAACACAACTTTCCCTTCCATAGAGAGTAAAAACCACGCTTTGGAGGGTAGATACAATTACCCCAGGGTTGTCTTTTCCCACTCCTCACAATCCCACCAGTGCACATGCAAGGTGATGTCCTTCCTTTAGCTATAGCAAATAATGTTAATTATTGTTGGTGTTAAATAATGATTATGTAAAGCACTAGACTAGACATTCGTCGGCAAAGTTTTTCTGCAAAGAATCAGATAGTAAATATTTTTGCTCTCATCAGCCAGACAGTCTCTGCGGCAACCATTCAAGCATTGTTGAATACATTGTTGAGTGTTACATGAGACTATTGTAATATAAAAGTAGCCTGGGACAACACATAAATAACTGGGTGTGGCTGTGTCCTAATAAAACTTTATTTACAAAGAACAGGAAGTGGCTTGGATTTGGTATCTGGCCTGGCAGCTGTGGTTTACTACTCCTTGGACGGTGGCCCAGAGACCCTTTAAATGAAATTCATTTTACTAGCACCCTTTTTCATCATGAGAAATATATTCTGTTTTTCTTAGAAAATGGGTTATGTTAGGTCTGGTCAAGGTAAATAAGTGTTGAGAGTCGATGTTGTGTGCATAGTTAATTTCAATTCTTTGAAGAAACTCCCCCATGATATTTCACGGCTGAGAGAAGAGGAAAGAGTTTAAGTGGAACAGTGTGCTTTGCTGAGCTTTGGAAATATTACCATATAGGGAAGCAGGTCAATAAGACAACTAAGTGCTGTTTCAATAACGAAGATACTGAAGCGCTAATTGGAGTATGGAACCATATAATGATGATAATAATTGCTAATATTTATCAGCTATTTATCATGTGTCATGTACAGCTAAGCACTTACATACCATCCCATTTTATCCTTATAATGACTCTAAGAGTGGGTTAAAAAATGGCAGAAGAATGGCAGTGTTTAATGGTTCAGCCTGGTGCAATGATTAACCACATTTTACAGACTAAGAAATTAAGAACCTCAACCAAGTTCATGCTAGCTGGTACGCAGTAAGGCTAGAACTTCGTCCAAAATCTCTTCTTCTGTTGAGCTCAGCTTGCATAGTAGCTTGGAGAATCAGAAAGATCTGTCTCATTTGGGAAATATACCATGTAAAAAACATTGTTTCTAAAGGAGATTTGTCCCATGAGTAAAATAGATGATGGACAGCCACTGCCTAGTGGGACAATTAGAAAGGTCAGTTCAAGGTTGGAGGAGATGCTTCTTTCAGCCAATTTTCCTTTTTCTCAGGATCACCTCAGGTGATCCGCCCACCTCAACCTCCCAAACTGCTGGGATTATAGGCGTGAGCCACCGCTCCTGGCCTTTCAGCCAATTTTCTATCACCAAAGGGAAATCGTTTTGCTGGAATATGTGTAAAGGAGGTTAAAGTCAGAAGAGATTCTCGTCCGCTCAGTTAAGGTACTCAGACTATTTTCCAACCAATCAAGAGGGTGCTGCTTCATGGAGTTCGTTTAAGCTGAAGCGGCAGCTGTTGACTGTCATTTGCATCATCTTTATACATTTACTGTGAATGTCACTGTCCATTTCCACTTTCTTTCTACTTGTCTTCAAATTGATGCTTATCAAGTAGACAGAAGAAGACCAAGGGGTCGTTTTGCTATTTATACCTCCAAATTGATGGCGTGATCACTCTCAAGTGCAAACCCAGCCCTGACACTGTCCTGTTTGGCAATGTCCTGCTATCTGACCTGCAAATAGCTACACTTCCTGCTGTGGCCCACCCAGGCCTCTGGGATCTGATCCCTTCTCCCATGTCACCTGTGGCCATGTCTTCCCCAACCCAGGCTTCTCTGCTCCGCTGCTTATGTTCTGGATCCTGACTCTGAGCCTTTGCTTGTGTGGCTCCTCTCCCACTTGTCCATCATCATGTCAGTTATGTAAGCATAGATTCCAAAGTGACAATGAGGGTAGTTAGGATGGCAAGAGGAGAAAAACCAAGCTGGATTCATGGATTGCTTGTGTCACGTCCTCTACAGAGCCTCCCTTCTACCTGCTCTTACCCGGGCACCACAGTTGATGAGTTATTTTTTGGACCATCAGCAACACACCCAATCATTGTACATGGAATACTTCGGGGATGCTTTTTTCTATATTGATTTTACTTCATTAAACTGAGCTCCAGAGGAGCAGAAACTTTGGCTAATACATCTTGGTCTTAGCTTGTAATATCTGTGCTACAACTTATTAAGATGGTGACGCTGGCAAATTCCTTAATCTTTCTAATTCTTAATTTCATCAGCAAAGATGGGAAAGGATACTAACACCACTCTGGGTTGTTGAGAGGATTCAATAACTGAATATTTATAAAGCGTAGTACCTGATACTTAATAAAAAAGTGAATTTTAACCTGTGTCATCATTGTCATCGTCTTTATCATCCTTTGCAATTATTACATTTACTGCCTTCTAGTACAAGGAAGGGGATGGGTGGCTGGCTGGCTAGGTGGATAGAAGGATGGAAGAGGTAAGTACAAGGAAGGGGATGAGTGGCTGGCTGGCTAGATGGATAGAAAGATGGAACAGGTAAGTATAAGGAAGGGGATAGGTGGCTGGCTGGCTAGATGGATGGAAGGGGTGGAAGGGGATGCAAGAGGTAAGTACAAGGAAGGGGATGGGTGGCTGGCTGGCTAGATGGATAGAAGGTTGGAAGACAGGAAGGATGGAACGGAAGAAGAGGGAAGAACAAAAATGGAAACACATAGTACTGTTAGGTGAACTGAACTTCTAAGGTGCCGATTCTCAGTGATAGAATCTTGAGTTGATACCTCCTTGGGTGGCATGGAGCCTATACCTTTGTAGATCTTGGGAAACAACTTCTAAAGTAATCATAGTTGTATGTAATCGTAGTTACAACAATAGTTATTTTAGGCACATAACCCAAAGGTTTTCTTACAAGGAATCTATGAACCTTAAGAGTGAGGGCTTCTGTTAAGAGTAAGGGCTTCCCTGGAGTGGACATGGATCATGGGACTGAGCCAGCTTGGCATTGTTGGGTTGAACAGGGAGCGACACCTCTCAGCCCAGTCTATCAAGCCTGCTCTTTGACCTGCAGTGAGACCACCCACGCAGACATCAATGCAGCAAATCCCCGGCGTCAGGGTTTCAACATTTGGTTACTCTCAGAGAACTCTCGATTTATATAAGACTTGGAAAAAGGGTTTGAGTTTCTGTGGTTTACAATTATATTTCCCAACTTGGCCCATGAATCCAGCTTGGTTTTTCTCCTCTTAGCATCCTAACCACCCTCATTGTCACTTTGGAATCTACACTTACATAATTGACATGTTGAGAAGCTGTGCTAAAACCACACTGAAATCACATTTTAATAACATGGGAACCATCTTTTCCCAGTAAATTGTTGAGAAGCTAATTCTTGTCAGCCTAAAAACTTGAATATACATTTGAATAAATCAGCGGTGCTACACCGTGGCAGCCTGCTGAAAATCCCCAAGGAAGATTATATTTTTAGTTGAGCTACTTGTCACTGCACTGTGTTTTTAATATTGTGAGTCCTTTCTTGTCTTCATTTTTGAAGAATCTATTGCATACCTTGTCATTCAGAAAAACATAAACGGGACCTCTCAATTAGCGGTAAAGTTCGTCAGTTTAACTTTTAAGCTTAAACTCCTGTTATAGTTCGGTCACTTACTCGTCATCAAAAAGATATTTGAGCTGATATTATGCAATAATTTATAACCAAAAACAGGAGGAAAAGGTCTCTGTTTGTCTCAGAAGTACAAGTTATGCATAAGGTGACAAATTACACAGCTTTGGGAAATGGGTCTTAATGGAATGCACCAGGCTAATAGAAAAGCAGTGCCTCGATTTCCCACCTCAGATCTGAAAACTCCTGAGAGACTGACAGGGCGGTTCCCCAGCTTGGCTGTGTGAGGAATCAGCTGGGAATCGAACACTGCAGTCTGGCTGTCACCCCCAGGATTCTAATGTAATTGTTCTGCATTGTGGATCGATGGATGGATGGATGAATGGCTGGACAGAAGGAAGACTTGGAAAAAATCTTTGAGTTTCTGTGGTTTACAATTTTATTTCCCAACTTGGCCCATGAATCCAGCTTGGTTTTTCTCCTCTTACCATCCTAAGGAGGGAGGGAGGGAGGAAAAGGGGGAAGGAAGCAGGTAGAAAGGGAACAGGGAAGGGAGGACTGGAGGAAGGAAAGCAGGGATCATTCTGGAGTGTACACTGGGCATTTGATTTTAAAGCAAATCCAAGAGATCATTAAATTTGTATCAATGAATACACTGTTACCCCTCAATCAACACTACAATTCATATATCAGAATAGCACTTTGTTACTTGTTTCTGAGATAGGGCTGGCTCTGTCACCCAGACTGGTGTGCAGTGGCACGATCACAGCTCACTATGGCCTCAGCCACCAGGGTTCAAGTGATCCTTCCACTCAGCCTCCTGAGTAGTTGGGACTACATGCCTGCACCATCATGCCTGGCTAATTTTTATTTTTGTAGAGACGAGGTCTCCTTGTGTTGTCCAGGCTGGTCTCAAACTTCTGGAATCAAGTGATCCTCCTGCCCCTGCCTCCCAAAATACTGGGATTACAGGCATGAGCCATGTCCAGCTGCCTTGTTTTTTTCTTTGAAGAGAATGATAGACCTTCCATAGGAAAAATGTTAAATATGTGTGTGCAGAAATAAAGATTTCAAATATTTTTGCAAGATATTTTTTCTAATACCACTTTTTTCTACATTTTCCATAATTTAGTGAAGATAGTAAATTAACAAAGTGGAAAAGACTGAATATTTTAAGAAAAGCCAAGTTTAAAAATTTTGAACCTAATATTTCTTAAAGTAGCTAAAATTCAGATATTGAGAATAAATTCAACTTGACATGGCAAAATTCTAATAGGCTGAAATAATGTTTTGGTCTAGAACTATGTAGCTTTGTGTAGCCCATCAATTGTCTAAAAAAAGAGTAACCTATTTTGATGAAACTCGCTGTATCTTGTAACCTGTATCCTGTCTTGGTATTGTGGGAGTATATATGATTTAGGGGAAAGAGTCTGGAGAGACCTTAAGTCTGCTTTAGGGAAAGGGTGAGGAACCCCACTGAAGGCTACTTAACGCATTTTGAGAATGTCAGTAAAGATTTCTCAGAGCCCAGGGATTTTTTTTTTAATTGAGACATAATTTACATACAATACAATTCCTTTTTTCTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGTGATGGTGTGATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTACTGAGTAGCTGGGATTACAGGTGTGCGCCACCACGCTTGGCTAATTTTTGTATTTTTAGTAGACACGGGGTTTCACCATGTTGGTTAAGCTGGTCTCAAACTCCTGACCTCTAGATCCGCCTGCCTCTGTAATCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCTATGCCCAGCCAAAATTCATTATTTTAAGCTGTACAATTGAGTGATTTTTATTACGTTCACAAAGTTACGTTACCATTACCACTTTTGAATTGCAGAACAATTTCATCACTCCAAAAAGAAATCTCATAACAATTAGCAGTTATTTTCCATCGCTACTTCCTCCAGTCCCAAGGCAATCAGCAGTCTGCTTTCTATCTCTACCTGTTTGCCTATTCTGGACATTTCATATGAGTGGAGTTAGATAATACATGGCCTTTTGTGACTGGCTTTCACTTAGCATAATGTTCTAGAGGTTCATTTATGTTATTGCAAAAATCAGTACTTCATTTCTTTTTATGGCTGAAAAAAATTCCATTATGTAGATGTGCCATATTTGTTTATCTGGTTGTCAGTCGGATATTTCTGTTGTTCCTACTTTTTGGCTACTGTAAAAGATGCTGCTATGAACATTATTGTGATTATTATACCTTATTTGTAAACATCATGGGTGGGGGGTTGCAGTAAACATGTTGGAAAGTAGGGTTGGAGGTCCGTAGAAATTGGGGGCTTCAGCACTTCCCCCAAGCTCAACACCAACCCCCTTTCTGAGCCCCTCTTGAAGGAGAGTTCCCTGGGACGTGCCTGGTATTGGTACAATCAGTCAGGAAGCATTTTTCCTGGGGAGAAACTTACAAGTCCACGATCAAAGCCAACAAGAGACAAGGTGTTACATGACTCATTTTCGGTTTAAGAAGTGACAGGCTGATTCTAAGTTGGGTTCAATTATTTTGTTAAAGCGTTTTGCTTATTTGACTTCTCCTGACCTCGGAAATAATTCTAACCAATCAGTGCTGGCTCCCATTGGCCCTGGGGTCTGGTTGCTTTACAGCTGGTGACAGGGGGACCACTCCACTACCACATGTGAATTAATCCTCAACTCCAGAGCCAAGTGCCATTCTCCAGCAAGGTTGTATTTCTTCATTAGCTATTCCCAGGGCCCAGAAAGTCCCAGAGGATGTCAGAGTACATTAATTTTTATCATAACATGGAATCTTTCAGGTCTGAATGGCAGCACACGGCTGTCAGGGGCTTCTGAACTCTATTACAGCTCCATATATCTCTAGGCAAAACAGAGGAAAGAGTCGTCATTGGCAAGGGAGATGTACAAAATGCATGAGATGTTTTATTTTTTGAGTGACTTGACCACGTGCTTAAGCACATTCCCCAAACAATTTTTTTCTTATTGTTTGTAAGTTGTAAGTTGTAAATTCACCTCTGCCACCACCTATTAAAGCCCACTCCCTGCATTAAAACTGTATAAAGTGTATTTAAATAAACTCTCTTTGCATGATGTGAATGAAATCGTCATCTGGTACTTAAAACTATTCTATAAAGTTATTAAAAAATTAATGTTCCCTTCCCATGATTTTTCTGCAGAATTTATGCATCCATGATACTGCAGAAGTTCATAAATAATGGCTTGTATTGCTGCTTTAGTATTGCTTTATGCCTACGAAATATAATGTTAATTTGTAGCAATGCTAATGTGTTTTCAGGAAGGCTCTTTGTTTATTGCCTTTATTTTCCCCACTTACCAAGTGGGTAAAATGCTTTGAGGGTTGCATTTTATGTATTCAGGAGGCCCAGGTATTATTTTAATAGAAGCACTATTGACAAATACCAGTCATCCCCCCTGTGCCAGGCCCTGGATGAGGCACTGCTTCGCATGGGGGCTCCCCAGATTGTCCCACAAGGAAAGCATAGTCAAAGACAAAGTTTTCAGTTGTAAGAGTAAATGTGTTCTGCCTAGGCATTGTCAAGTAATTTACTGCCAGCTCTAGCCCTTCACTCAAGTTTCCTGGATACTTTTGACTTCTTAGCCATGGATGTGTTTGAAGGCTGCATGGACCTTCACTTACTTGCACTGCAGGTCAGCCTAATTGCATGAGCTCTGTGGACCACAGAGCAGGGTTTTCCAAAGTTCACCAAGACAAATATTGTATTATCTTAACATATATTCATTTTTTAAAACTGAAAATCAGAAGAGCAACTCCACCTAGCAGAAGTCTTTTGCAAAGGGCGAGGCGAGGCTAAAAAGTATAGAAGAGTTCGTTTCCAGTGCAATTTTATAAACACAGATGGTCCTTAAATTAAGCAAATGGTACCTAAATGACTGTGTTGTGGATAATGGTAACAGAGGGAGGGACTCGGGGGTTTTTTAAAAAGTACTGATTGTATGCAGTGTTTTAAACAGATAACTGTGATCTTAGTGTGATGAAAGATGCTGGGAGATTTCACCAGTGGTATCTTATTATTTTTCGGGGATTTTGTAATTCAACAAAATTCTGTTGTATGCCAAGCATAACCCTAGGTGTGAGAGCACAAGGTGACTTCAGATACCACCTCTATCCTTCAGGGGTTTGGGGCCCATTATTATGACTTAATCCATTTTGGGCGTGAGAAGCTGAGGGTCACAGAAAGAACCAATTCCCTCTTTAAATAATGCCACCCCAACCCTCCTCATCTGCCAGGTCTTTCCCTTCTTCTATTTGTATGAATAATAGTCACTTTCTCTTGTGGAGTTCGCTAAATTCTACTTTGGCCTATCAAATTTCTTTCATATCACAACTAAATTTCTTAAGGACGGGACTATGGTTCATTTGTCAGACGAACAAATGGGAATTTGCCAAGAGACACTTGGGTTAATTTACGTCTTTTCCATCCAAGGGCACTATGTTGAAGTGAGGCTAGTAGGTCATGAGTGTGGTTGAAGTTACTTTTTCTTACTTTCCCGACCAGCCCCCATCCTTACTGCACTTAAAGTTGATTGTCCATTTTATTAAATGTCCCCAGGAAGCCAGAACACAGGGCAGTAAAGTGCTGAATGCAAAGGGCAGGAGAAAAATGGAAACAACCAGAACTGTAACACCAAGGAATGAGACCTGCATGTCAGATATCATGCCCATTGCACTAAGTGCCATTGGGGCACAATTATCAAATGGATGCATTTTCCCTAGAAAACCATCTTGGAGAGCATGTGGATGTACTTCTATTTTACATTTCCCCCTATTTACAATCAATGAGATTGAGATTTTGTTGCTGGGACTGCTGATGATGGGATGGGAAAATATAATCAAGGTAATGGACATGAGGCAAAAATTTAAGGAAATGACAAAAACAAGAGTATTTCCATTTTCAGTTAAGTGTATGTACTGATGTTCTGGAATTCACTATAAGAAGTTGCAAATGGTGCATGAAATGAAAAATTCCTGGTGGTCTCCAGGGGACACAGCCGGTGCTGTGCTCCACTCTGGGTAACTGTTTTGGATTATTTTCTCTATTCCAACTGAAATAAAAAAAAATTAATTAAATGTGGCTAGGTTATCTTGACAGCAGAATCCATTCCCAGTTAATTATTATTTTAATACTTGATGGTGTCTGTCAAATTGTCGACATGTGACGGTCCTTTCAAATTTAAAGGAATAGCTGATGGTCACTGGCCACCCAAGCTGATACTGATTTTATATGTTGATGTTTCTCATTTTATTTGCTCTTTCCTTGAATATTTATTCAGGACATTCTCTACCAGACATATTGAGTAAGGGCAACAGAAACAATACATAAGTATCTTATAAATGTGGAAAACAATGTATATGTGTTTTTTATCTCTCAATGATTGGTGGGTACCATATCCCCAAAGTAGAATGAGCATTTGAGAAAACAGGAAATATCCTCTTTTAGGCACCATCTCTGTCAAGGCTGATGCTGGGCTTTTTATATATTTTCTCTAATTCTTGTGGCTGTCAAACAAGGTGGGCATTATCATTCCCTTTATAGGGGACACAGCTGTGGCTCAGAGGGGTTTATTCACTTTCCTGAGGGCCACACACATAATGAGAGGCAGACACAGGTGACGAAGTGAGTTTTCCCTGTCACGCCATCTTATCTGTCACATACCTCTCTGACATGCTAAAATTGCACTAAACAAAAGAATTCTCTTATGCACATATCATGCAAAAGATATTCTTTAACTGGGGATCATGTTTCTCATTCCATCAATAGAATGACTAACATTTTCTGAGGGTGTCTCACGTGAAAGTAAATCGCTCATGTTTGTTCTTTTTAAAAGATGCCCTTCGTATTGTGTATCTTGCAGTCTTGCTTTCTCAAACTTAAGCCAACTATATCGTCATTTTTGCAAAATCACTGCGTCAGTTTACTATTATTTAATGTTTATTGCTACCAATTTTAAGAAATCCTTTATAGGACTATTTGTGAAATTGATTTTGTGAGGATGATGATATAATTTCCATTACATTACAGCATATAAATATAAATATATATATATATATATATATATATATATATATATATATATATATATATATTTTATTATTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGTAACCTCCGCCGCCCGGGTTCAAGCGATTCCCCTGCCTTAGCCTCCTGAGTAGCTGGGACTACAGGCATGTGCTACCACACCCAGCTAATTTTTTGTATTTTAGTAGAGATGGTTTCACCATGTTGGCGAGGATGGTCTCAGTCTCCTGACCTCGTGATCCGCCTGCCTTGGCCTTCCAAAGTGCTGGGATATACATTTTTTTTTTTTTTTTGAGAGATGGAGTGTCACTCTGTTGCCGAGGCTGGAGTGTAGTGGCGCAATCTCGGCTCACTGCAACCTCCTCCTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGATTACAGTCGTGTGCCACCACGCCTGGTTAGTTTTTGTATTTTTAGTAGAGATGGGTTTCACTGTGTTGGCTAAGGTGGTCTCAAACTCATGACCTCAAGTGATCCGCCCGCTTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTCAGCCACTGTGCCCGGCCGGATAGAAATAATTTTTATAAACTCCTTGGATGCTACCTAAAATCATCTTGTTTTGCTAGTGGCACATGCTGCATTTTGGGCAGCTGTGGCCTTGGTGGATTGCTGAAGTAGATTTGACCTTACCTGGACTGAGGCAGCTGTTGAAGGGAATTGCTGTGTTCAGTGTATACTGCCATCCATGATTTCATGAAACCAGCTCTAGCTATTTAAGCAGGGGTCAAACTTAGAATTCTACATTATTTTTTTCCCTTTTCTGGGAGGAAAGACAGTTGAACACCAGCAAAGACTAAGAAGTTTCTTAGAAGACTGTGGGTCCTTGGGCCCTTTCTATTGAATTTCAGAGTATTTCCAAATACTATGAAGTCTTGCAGCTTAGTTGAGAAATGCCCCAGATGGTGTGACATTCTGCTTCCAGGAGGGATTGGAAAGTATTTCCTTTTACATAACATTCCACTCAGCTCATTCCTTTGCTGTGTCTGAAATTGAATCCCCCAAAGCCACAATTATCTTAACATTCAGAAGAGTGTTTATTTAATCTGCAAAATCTTGCCTCACTTTTGGGGAGCATGTTAACAATTTCACTTACAAATCTTCTGTGTAACTCAACCCCATGGTGGTGTCTACTGCTGCTCCTAGACTCTTTAAAGCACCTTTCTCATCTCAGGTTTGAAATGATATGTCTCATTCTTGGGTTCCTTGAGTCGTAATGGGTTTGTCTTGTCTCCACAGCATAAATGACTCTTTCTTGATCAACTAGAACCACATCAACTTCTTCCCTCCAGCTTCAGTGATATATTGTGAAACATGGCTATTCAACGTCCTGTAGACCAAATGCCATAAGAAAAATAGCATTGATTCAAACGTATCCATCCAGATACCTAAAAAAGTTTTACTTCTTACCACATCTTGAGTCTGGGCAAACACGCACTTCCTATGGACATTGATTACTGTCTACTGTAGAGATAACATTTGCACATACAGATTATGGCACATGGTAGAAAGTGTTAAGTAATGTAGGAATGGACATATCCCAAGCAAAATTGGAAGCCAAGTCCCCTGTCCCTGCTCAAGTTGGTATGACTGGTGTATGGTGCCTTAATGGGTACTTAAAGTCCAGGTGAGAGTGGCAGGAGGCAGCCAAATGCCTAGGTAGATAGGAGCCGGTCCCTGTTGAAACCCCACTTCCAAGTTGAAGACAGTTTAAAGACTGAAAGCCAAGCTACAAGTTAAATCCTCGGACCAGATTGAGAACTTGTCTTCTTACTTGGTGCACTCTTCTGATTGATCCCCACCTTTCACCTATTTTACATATTCCTGCCCTTCCCTAACTGGTTTCCTATGCTGTCATGCCCACCTTTGAGTGTTGCCTTCACTTTAACCTTCTGTGCATGCTCACAAAGTAATTAGCATGTACCCTCCATTCTGAGTTAATATAAGGCCCCAGACCCAGCCACATGGGGCAACTTTACTGCCTTCAGGTAGGGGAACCACCCCCACCACATTCCCTCTCCACTGAGAGTTTTCCTTTTAGTTAATAAATTCGGCTCCACTCACTCTCCATTGTCTGCATGCCTAATTCTTCCTGGTTGTGAGACAAGCAGTTGGACCTAGCTGAGCTAAGGAGCAGAAAGACTGTATCACAGGGAACTTGTGTAACAGCTTGATCTCCTGTCCTACGTAGCTATCTATTGGTAAGAAGTTGAAGGAACTTGTGTCATTCCGTTGTGCCTGTCGTCTTGACCTTGTAAAAGGTCTTGGGTAAGCATGCAAGAAGTTTTGAAGAGGGAGATACAGCTAATTTGCAGATAAAGAGCAAGGGAAGAATTCCTGGAGAAAGGAAGAGTTTCCTGAGTCACCTTTGGGAGGTAGGAAGGGTTTGACATGTAGGCTGGGCATCTGGGAACGAGTGAGGGATTCTGTGAGCCCCATCTCAGTGGACCACTCAAGGAAGGTGGGTAAGCCCTGGGTATAAGTGTGTAAGCAGGGAACAGAAAGTACTGTGATTTAAAATATGTTAATTTTTCTACTGTACAGATGAGAGCCAGCTTGGAGATGGGCTGTAGCTCAAGCATCTTACCTACCTCTGATTTCTTAATGCCACGTTATAAGGCTGCTGCTTATAGCTCTTGAAGTCACTCCAAAAACAGATGAGTGAGACCCTGTTGCTAAAGTCCCACTGGGTGTAGATTATTCACAGATGTATACACAGTGGCTCACTCCAGGTAGGATGTGATCAGTGCTTTTAGAAATACAGAAAGTCCTATTGGTTTAAAAAAAATTTTTTTTTGTAATGAATTGAGTTTTAAAGCTAGCACTGTACAATAAAAGGGTGAATTTCACTATGAATTATGACAAACACAGTCATAGAGCTGCCATCATCACTGTCAAGATACAGAACAGTGCCATCACCCCCCAAATGTCCTCTGTGCCTTACTGTAGTCATACCTGCTCCTGACACCTAGCCCCTGGGAACCATTGATCTTTTTTCTGTCCCTAGTTGTTTGTCTTCTCTGCAATGTTACATAAACAGAAATATTCTGGGTGTCGCTTTTGGAGTTTGGATTCCTTCCCATAGCATAATGCATGCAGTATTTGTCTGTTTCTGCTAAATTACCCCCAAGACCTAGCGACTTAAAACAGCAAACATACACTATCTCACTCTGTTAGTTTTCCATTGCTGTTGTAATAAATTACCACAAACTTATGTGCTTAAAACCCAAAGCTATTATCTGACAGCTCTGTAGGTTAAAGATTTGTCATGGTTCTCATTGGGCTAAAATTAAGGTGTCGGTATGGCTCTGCTGCTTTCTAGAGACTCCAGGGAGAATATTTTTCCTTGCCTTTTCCAGCTTCTAAAGGTCACCCACAACATCTTCAAAACCAGCACTGTTGCATCTCTGACCTTAGCCCTGTAGTCCCATTTCCCTCTAGCCACAATCGGGAAAGGATCTCAGGACTGTTGTGATGACACTGTGCTTACCTAGATTATCTAGCATGAGCTCCCTGTCTCAAGGTGATAGAGTTTGCATGTTTTTCTCCTGCACATGCCATGTTGAAACATAATCCCTAGTGTTGGCGGTGGGTGTGCTGGGAGGTATTTGGATCATGGGGGTGGAACCCTCATGCATGACTTACGGCCATCCCTTTGGTGATAAGTGAGTTCACATGATATCTGGCACCTTCCTTCCTCTGTTGCTCTTGCCCTCACCATGTTAGCTGCCTACTCCCCTTTTGCCTTCCGCCATGACTGTAAGCCTCCTGAGGCCTCACCGGAAGCCAAGCACATGCTTCTTGTAGAGTCTGCAGAATCGGAGCCAATTAAATCTCTTTTCATTATAAATTATCCAGCCTCAGTTACTTCTTTATTGCAGTGCAAGAATAGCTTAACACACAAGGTCTTACCCTTGATCACGGTCTGCAGCATGTCTTTTACCATGTAAGGTAATATGTTCAGTGGCTGTGGGGGTTAGGATGTGGACTTCTTTGGGGGACTTTTATTTTTCCCAGTTACTATTTTTGTGACTCAGGAATTTAGGGACAGTTTGGCTGGTTGTTTCTGGCTCAGGGTCTTTCTTGGGCTGCAATCAAGATGTCAGCTGGGGGCTGGGCATGGTGGCTCACTCCTGTTATCACAGCACTTTGGGAGGTCGAGGTGAGTGGACCATTTGAGGTTAGGAGTTTGAGACCAACCTGGCCAACATGGTGAAACGCCATACTAAAAGTACAAAAATTAGTTGGGCATGGTGGCACATGCATGTAATCCCAGTTAGTTGGGGGGCTAAGGCTGGAGAACAGCTTCAAAACAGGAGGCGGAGGTTGTGGTCAACTGAGATCACACCACTGCACTCCAGCCTGGGTGAAAGAGCAAGGCCCCACCTCAAAAAAAAAAAAAAAAAAAAAAAGTTAGCTGGGGCCAAGGTCATCTCAAGTCTTGACTATGAAAGGACCTAACATCATGCATGGCTGTTGGCAGAGGTCACTTCCTCATGAGCATTAAACTGAAAGCTATAATTCCTGACTATTGACCAGAGGCGAACCTCAGTTCCCTGCCATGTGGGCCTCTTCATGGGGCAGTTGATAACACAGCAGTTAGCTTCCATTGGATTGAGTAAGCAAGAGAGCAAGAACAGGAGTGATACAGAAGCCAGCATCTTTTTGTAAACCAATCTCAGAAGAATTGTCCATGATTTTTTCTATATTCTGTTAGTTAGAAACAAATTCCTAGGTCTCACCCACCCTTGAGGTGAGGGGATTACACAAAAGTATGAAAACCAGGAAGCAGGGAGCATTGGGAGTCATTTGGACCCTGCCTAGGACAGTGCGTTTGAGATCCATGTTATTCTATCCATTAGTAGTAGTTTGCTTCTTTTTAATGTTGAGTAATATGCCATTGTGTGTTTATATATTGCTAATGGATTTTAAAGAGGGCTAATCAACGTGTTGATTAGAGGGAAATTTTCTTCAGTGAAATAATATTTGAGCAAAACCTTGAAGAACAATTAGGAATTTGACAGAGGGAATGGCACGAATAAAGACCCAGACTTAATCAAGTGAGGGGCGTACTCATCCATGGGGCAGTGGATGATTCACCTGCCTGGAGCTTAAGGAGAAGGGGGTGTAGTTGTGGCTGTTGCTCAGAAGGACCTGAATGTCAGGATGCATTTGTGTTTAATTTAGCAGACATTTAGGAACCATTAAAAGTTTTTGAGAATGGGTAGGTAAGATTAGAATAGTATTTTAATAAGTTTAACTAGGCTTTAACCAGTATTCATAAAAAGTCAAGTGGGAGAATGTAGAGGTGACAAGACCAGGTGTGGGCTATTGCAGTGACTACACCTAAAAGGAACAGAGCTAGAAACATGGAGTGACATGAAGTCATTGTCTTAGGTTGGTGATCCTAGCAGCTGAGCCTGGGATGGGGATTCTTGTTCCTATGATCGATTAGGGGACTGTTCCCAGAGGAGAGCGGAGAGGGAAGCAGGCTTTGGTTTCTACTGGAAATCTGTTTCCGCCCGATTCCATGGGGAGCTCTGGAGAAGGAATTGTATCACCGAGTTGGTCCTCCTTGTCAACAGAGCATGTGTGTGGGGGTGATGACTTCCCAGATGTGAGGGTGCCCTCCAGCAATGGACAGTTATCTGGAGGAGTTCATGCTCCAGAGGTAGTGCCTACCTCTGTGGAGAAGTAGGGGATGGCACGGTATTTTAGGGGTTCCTAATGAGCCTAGAGATACTGACATTGACCAGTCATGGAGACTAAAGGAGAAGATGGGATAGCACATTGTTTTCCTAAGTATTTGTAATCAGGTGACTGGTTTGCAAATATCAGCCATTACAGAAATAAAGGGTATCAGGACGGGGAGGAGATGTGAGGAGAGAAGATGAAGAGTTTAGATTTAGGCATGTTGACCCTGAATTTGTGGGAAGGTATCCAGGAAGATAAGACTGACAGGTGGGAATGAGATTCTGGAACTTGGAAAGAATATAGTGGCTAGAGCTAAGGGTTTGAAGTCTTCATGGCGATTTTGTTCGGAGTCATGGATTTGGAAGAAACTGCTGCAGGGAAGATTTTAGAGATGGAATGAAAAGAGATTGGTGATGGAACAATGGGCAAAAGAGGAAGGGTTGGAGGAGACAAAAAATGGAGTGGTAGTGGCATTGGGAGGTCCAAGAGTGGATGGTATCACAGAAGCCAAGACAGGAAAGTGAGCCAGAAGTGAGGGAGGAGCAGGATCCTCTGCAACAGGGCAGTCTAGTCTTAGCAGAGAGGAGGTTGCTGAATTTATTGATTGAGAAGCCACTCCTCGCCAGGCAGTTTTGAGAGGTTCTGGATGGTGATAGAATGGAATTCATTCAGCTGATGATGAGAAGTAGATTTGGGTCAGGGAAGGAGACTGAATGGAGATGAATATTTCAAAACTATAGACCATAAATGGGAAGAGAGAGACGAGTGCAACCTGCCTAGGTCAAGTGAATGTCCTTTTTTCTCTTCCCAGCCCTTGTCTTTTTTACCCTCTTTGTTTTCTGCATTTCTTTCCTTCTGTTCTGATTTTTCCTTACCTGATGGTCAGAAAGATCTGATTGAGCTGACGCGTAGCAAGAATGAGCCAGTGGAGAGGAAAATGTAACCACCTAATGGGTTCTCCTTTCCTGCTAGCTGGACAGAGCTGATTTATCAAGACGGGGGTACTGCAAATAGAGAAAGAATTTAATCCACACAGAGCCAGCTGTATGGGAAACCAGAGTTGTACTACTCAAATCAATCTCCCCGAGAATTCAGGGATCGGAGTCTTTAAGGAGAAATGTGGTGGATAGGGAGCCAGTGAGTGATCTGGGAGTGCTGATTGTCTCACGTGTCCATGTGAAGAGACCACCAAACAGGGTTTGTGTGAACAACAAGGCTGTTTATTTCACCTGGGTGCAGGTGGGCTGAGTCTGAAAAAGGAGTCAGCAAAGGGTGATGGGATTGTCATTAGTTCTTAGAGGTTTTGGCATAGGCGGTAGAGTTAGGAGCAATGTTTTTGGGGCAGCGGGTGGATCTCACAAAGTACATTCTCAAGGGTGGGGAGAATTACAAAGAACCTTCTTAAAGGTGGTGGAGATTACAAAGTACGTTGATCAGTTAGGTAGGGACAGAAGCAAATCACAATGGGGGAATGTCATCAGTTAAGGCTATTTTCACTTCTTTTGTGGATCTTCAGTTGCTTCAGGCCATCTGGATGCATACGAGCAGGTCACTGGGGATATGATGGCTTAGCCTGGGCTCAGAGGCCTGACACTGATTTGTTGGCTTGAAGATGAAATCACAGGGAATCAAAGGTGCCCTCCTGTGCTGACTCAGTTCCTGGGTGGGGGCCAAAGGACTGGTTGGCAGGTCTGCATGGGGCCACCGTGTTGTCAGAAATGCAAAAATCTGGCTGGTGCAATGGCTTACCCCTGTAATCCCAGTACTTTGGGAGGCTGAGGTTGTCAGGCCTCTGAGCCCAAGCTGAGCCGTCATAACCCCTGTGACCTGCACATATACATCCAGATGGCCTGAAGCAACTGAAGAACTACAAAAGAAGTGAAATAGCCAGTTCTTGCCTTAACTGATGACATTCCATCAGTGTGATTTGTTCCTGCCCCACCCTAACTGATCAGTTGACCTTGTGACATTCCTCTTCCTGAGGCAGTGAGTCTCAGGAGCTCCCCCACCGAGCACCTTGTGACCCCCGCCCCTGCCTGCAAGACAAAACCCCCTTTAACTGTAATTTTCCACTACCCACCCAAATCCTGTAAAACTGCCCTACACCTATTTCCCTTTGCTGACCCCTTTTTCAAACTCCGTCTGCCTGCACTCAGGTGATTAAAAAGCTTTATTGCTCACACAAAGCCTGTTTGGTGGTCTCTTCACATGGACACGTGTAACAGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGTGAAACCCTGCATCTACTAAAAATACAAAAATTAGCTGGGCATGGTGCTGTGCACCTGTAATCCCAGCTACTCAGGAGGTTGAGGCACGAGGATCACTTAAACCCAGGAGGAGGAGATTGCAGTGAGCCAATTGCGCCACTGCACTCCAGCCTGCAATGCAGAGTGAAACTGTCTTAAAACAAACAAACAAACAAAAAGCAAAAATCTGAAAAGACATCTCAAAAGCCAATCTTAGGTTCTACAACAGTGATGTTATCTGCATGAATAATTGAGAAAGTTGCAAATCTTGTGACCTGAGGAATAACGGCTGGTAATTATTTAAAACTCAAGCCCCTCTCATCCTAACGTGGTGGCCTTTCATTCATTTTACAGGAACAGTTTAGTTTTGGGGGAAAGCTGTTATTTAAACTATAAACGAAATTTCTCCCAAAGTTAGCTTGGCCCATGCCCAGGAATGACCAAAGACAGCTAACCAGTTACCGGAAACGGGTCCCAATCTAGACCCCAAGAGAGAGTTGTTGGATCTTGGGCAAGAAAGAATTTGGGGTGAGTCTATAAAATTAAAGTAACTTTATAAAGAAAGTAAAAGAATAAAAGAATGGCTACTCCATAGGCAGAGCAGCAACTTTGGCTGTTGGACTAAGGATATTTATAGTTAATTATTGATTAGCTATAATATATTTTAATATAATATATATAATTATAATACAATATTATATATAATATATATTTTATGTAACTATAAACAAGGGGTAGATTACTCATGAGTTTTCACGGAAAGGGGTAGGCAGTTCCCGGAAGTGAGGGTTCTTCCCCTTTTTAGACCATATAGGGTAACTTCTTGATGTTGCCATGGCATGTGTACACTGTCATGGTGCTGGTGGGAGTGTCTCTTAGCGTGCTAATGGATTCATATTAGGGTATAATGAGTAGTAAGGATGACCAAATGTCGTTGCCATCTTTGTTTTGGTGGGTTTTGGCCGGCTTCTTTACTGCAACCTATTTTATCAGCAAGGTCTTTATGACCTGTATCTTGTGCTGACCTCCTATGTTATCCTGTAACTTAGAATGCCTGACCTCGTGGGAATGCAGCCCAGTAGGTCTCAATCTTATTTTACCCAGCCCCTATTCAAAATGGAGTCACTCTGGTTTGAATGCTTCTGACAAACCTCTGAGACTAAGGACAAGATGGAGTCTGTTAGGTTAGTTTTAATTTCCTCAGTTATTATTTCACAAAGGGGGTTTCAGAAAGATAGAAAATGCTAGAAAGAGACGGGGTAGTCAGTGGTAGGGATCTTGAGGGGTTAAAAAAGGGAAGGAGCTGGTCCCTTTGCAGTAGGAAGTGCCACCTCACTCCACTCTTGCCAGAAAGCCTGGCTCTGTCATAAGGAATCTTGGCCCATTGTCACTCTCATTGATGACAACCCCCGCCCCCACCACTACCACCTTAACTACTGAGGGGATGTCCTCTGGCCCAGAAGGAATGCATTGGCTCTAGTTGAAGGGGTTGCTGGTTTGTAAATAGCATCCCCACAGTCAGCAGACACAGAGAATGCCATGGGGCCACTCATCAGAAAGGTGGAGGGGCTTTATCTGTGGGTAGATGAGAGCCATGTAGAACCTGCATGCTGCCTTCCATTGGAATCTCAGGCTCTAAACAAGGAGGACAACCTTTTCTGCCCTTAATCACCTCTCACAGATGAGAATCCACCCAAGAAGAAGAAAAAAAATCAGCCCCTTAAAATGCTGACTAGTAACATCAGTTTTTGGAAGGATACTATTTTTGTTTCCATTCTGTCTTTATAGTTTGAACTTTTCCTTTTCATAGTCTGTAAATATTCATCATCTCAGAGCCTTTTGAATTGCAATGGCTTTTAGTCAAAACTGAGCGCAATGTGCCATTTGAATAATAAGAACCTCATTAAAGTGAGGCAAAAGTAATTCTTTTCCTTTTGTACAAGCCAATTAAGTGTCTTTACAATTAAAACAAAGTCAAGCACTTTATAGTTTCATATTCCACAAGCCTGTTTTTAATTAATAGAGGTGACAAGTTTTAGGTACAGGATACATATTTTGCCTCTGGAGTTGTGCAATTAACATTAATGAAGGGTATTAAAATTTGGTGAGAGAGGAAAGGGTTTTCCCAGGTCCTCTGTGGGTTCTTGCCTCCAGGCCTGTCTTTGGTAGCAAGTTCCTTGGTTTGCTGAGGTTTGCATTTTCTTGAGAGAATGTACAGGCAAGAATAAAAGTAACTAGAAGAGACATTGTTGTTATTGAGAAGTATGAAGTTAAAATTCCCAATGTCCAGGCCTGTCTTAAAATTAGGTAAACACTGCAGAAACTATCTTTGAGGAATTTAATTTTGTCTTGTGGATAAAAGTGAAGGATAAAGAGGAGAAATAACAATTATCTAAGCTGGCAGGCCAGCAAGATACTGGGGCTTTACTTCTCACAACCATGGGAGGAGTATATTTAGTTTACAGGGGAGGACACAGATTCACAGGGGTGAACTAACTGGCCATGAGTCAGGTAAGGAAAATAACATGGCTGAGCTACAGTTTCTCTAAGAAGTTGGTTCTGTCCATTTCAGGGAGCTTATGTAAGACAGAAGGTATTGTGCAGTAGCCTTGAAGTCAGGTGACCCTTTGGGGGTGTGTGTGTGTTTGCTTCTTTATATTAGCTTTTTTTTCATTTTGAGACAGGGTGTTGCTCTTCCTCAGTTGCCCAGGCTGGAGATCAGTGGGGTGATTACAGCTCACTGCAGCCACAACCTCCCAGGTTCAAGAGATCCTCCCACCTCAGCTTCCCAAGTAGCTGAGACTACAGGTGCATGCCACTGGCTATTTTTATTTTTTTCTTTTTAGTTTTGAGTTTTTAATTTTTTGTAGAGATGAGGTCTTGCTATGTTGTCCAGGTTGGTCTTGAACCCCTGAGTCCAAAAGATGCTGCTGTCTTGGCCTCCCACTGTGCTGAGATTACAGGCATGAGCCACCATATCTGGCCTATGTTAGCTATTTCTGAAACTTCATTTCTGTCTGTAAATGGCAATCATAATATATGTCACGTAGGGTTCTTAAATACAAAAAGCTCTTAAAAAGTGCCTAACCCATAGTTAGTACTCAAAAAAGGAAAAAAAAGTATTAATAGCCCTGGAAAAGTGAGCAAAATATTTCAGATGCAACCTGAAAGGAGTTCAAATGTAAGTCTCTCTTCACTTTGCCCATCTTTCCCTCTTCCCCGCAAGGTTTTTAGCAGTGGTCCTGTCTTACTACAATATATGAATTATCCCTGCTACAAATTAGTAGATTCTGCTTTGATTTGAAGCAGAGTCTAATGAGTGTTACAGGTAGGCTCGGTGCTTCAAAGGATTTCTGCCTATCTCTTCACAGAGTAGCTGGGCTATTGAGGGACTGTGTATTGACAATTGTAGTGGGCACCCTATGTGGAAAACAGGTGTTGTCAAATAACTGCAACTGACCCCAACCACACCATGACTTTTCAGGTTTTAGGTAGGGGATGGGTGGGAAAACAGATGAGGCAACAGAATGAATTATTCCTTAATAAGATCCAGATTACCGAGTGATAATAAGATTTGCATGAATACTTCAAACAACAACAGTGATTAAATACGTTTTTCTAGTTAAAAAATTAATGAGTGCTTTCCAGCAAGCGCTTAAAGAATTAATACTGGCCGGGAACGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGTGGGTGGATCACGAGGTCAGGAGGTCAAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAGATTAGTGGGGCGTGGTGGCGGGCACCTGTAGGCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGCAGGAGACAGAGTAAGACTCCATCTCAGAAAAAAAAAAAAAGAATTAATATCAATTTTCCACAAACTCTTTTAAAAAAACAGAAGAGGAGGAAACACTTTCCATCTGACACTGTGAAGCCACTATTACTCTGACAACAGAGGCAGACAAAGATATCACAAGAAAAGGAAACTTTAGGTCACTTTCACTTATAAATAGAGATGCAACAATTTTGTACAAAATGCTAGCAAGCCAAATGCAGCCACATATACAAAGAATTGTATATTATGACTAAGTGGAATTTATCCAAACAATTCACGGTTGGTTTTATATTAAAAAATCAGTCAATATAATATAACATAATAGTAGAATAAAAGATCCTCTCAATACATACATAAAAACATGTTTTAAAAAGGTCCAGCACGCTTTCTTGATGAAAACTTTTAGTAAACTTGGAACAAAGTGGCATTTTCTCAACTCAATAAAGGGCATCTGCAAAAAACCCACAAATGACATCATAATTAATGCTGAAAGATTGAGTACCGTCCCCTTAGGATCAAGAAATAAGACAAGGATATTCACTCTCATCACTTTAATATTCTACTAGAAATCCTAGCTAGGGAAATTGGGCAAAAAACAAAAAAGCAAAAGAATGGAAAAAAAAGATCCAGATTGAAAAGAAGTAAAACTATCTTTATTTGCAAATGAAATCACCTTATCTGTAGAAAATCCTAGAAAGGTACTTAAAAAATATTAAAATGAACAGGTTCAGCCAGGATAAAAGTAGGATAAAAGTTTAATATGCGTAAGTCAATTGTATTTCTATATACTAGCAATGAAGGCATCCCATGTTCATGTATCAGAAGATTTAATATTGTATAGCTGACCAAACTCTGCAAATTGTGTACAAATTTAGTGCAATCTCTATTAAAATTTCAGTTGACTTTTTTACAGAAATTGAAAAGCTGATCCTACATTTTGTATATGAATGCAAAGGAACCTGAATAACCAAAACAAGCTTGAAAAAGAAGAGTGTTGGAGGGCTTCCATTTCTCAATTTCAAAACTTTCTATAAATCCTTAGTAATAAAGACAGTGTCATATTGGCATAAGAATAGATCTATAGATAATAAAATAGACTTGAGAGTCCAGAAATGAATCCATGCATATTGTGAATTGATTTTCAGCAAGGATGCCAAGACAATTCAAAATAGTCTTTTCAACAGTGATGCTAGAACCACTGGATAGCCCCATGCAAAAGAATGAGATTAGATCACACTTGCATAAACTACACAGCAAAAAATAGCAAAAAAAAAAAAAAAAAAAAAAAAAGGGTCAGAGACTTAAATGTAAGAGCTAAAACTATACAACTCTTAGAAGCAAACATAGGGGTATATTTTTCTGATTTTGGCTTAGACAATGATTTCTTGGATACAACCCTGACAGCACAAGTGACAAAAGAAAAAAAGATATCCAGAATGATCCAGAATGAAAAGTGTTTGTGCTGCAAATGATACCATCACGAAAGTGTACAGATGACCTACAGAATGGGGGAAATACTTACAAATTAAATATTAAATAAGGGATTTGTATCTAGAATAAAGAACTTTTACAATTCAATAATGAAAACTCATTTAAAAAATGAGCATAAGATCTAAATAGATATTCCTCCAAATATGATACACAAATTGCCAATGAATACATAAAAGATGTTCAATCTCATTAGGGAAATGCAAATGAAAGCCACAATGAGATTCCACTTATTGCTAGGATGGCTAAAATAAAAAAGTCAGATAACAAATACTTACAAACACATGGAGAGATGAAAGTTCAAATACAGTCCTGGCGGAAATGTAAAATTGTATGGCCAAACTGGAAAACAGTTTGGCCATTATTCAAAAAGTTAAACATTGAATTACCATATGACCCAATAATCCCACTCCTAGATGTATCTTGAAGAGAAATGAAAACATGCATTTCCATAGCATCTTACAAATGAATGTACATAGTAGTGATATTCCTAATAGCCAATAAATGGAAACAATCCAAATATCCATCATTGGTGAATGGATAAACAAAGCGTGGTATATTCATATAATGGAATATTATTTGCCCATTAAAAAGAAATGGATTACTGATATATGCTACAACATGGATGAACCCTGCAAACATCATGCCAAGGGACAGAAGCCAGTCACAAAAGACTACGTATTGTATGGTTCCATTTAGTATATAAAATGTCCGGAATAGGCGAATCTATAGGACAGAAAGTACACTGATGGTGTTTTGGGAATAAGAGTGTAGGTAGATAGAGGGTGGCTAGTGATTGCTAATTTTTTTTTTTTTTTTTGAGTTAAAAAAGTGCTATAAAATTAGAATGTAGTTATGGTTGTACAATTATTTGAGTATACTAAAACAGCTGTACAGTATACATAGGTAGATTTTATGGTATGTGCATTATATTTCAGTAAAGTTCTTTAATAAATTAGCTAATGCTTATTGTAGAAAAGTTGGAAAATACCAAAAACCATAAACAGGAAATAGGAAAAAAAGTAATCCTGACTGTATATCTGGAAATCTTTTCGTGGGGTATGGGGTATGAATCACACATATTAATTTTAATTTCCTGCTTTTTCAATTAAATTGAGAAAGTTTGGGAACCTCTGGCTTAATCATTATTTATCCACTTCTCTGTTGTTGGATGTTAGATTGCTTCTAGTTCATATGTAATTTTATAATTTTAGTTGACATGTCATTATGGATTCTTGGGCATAAACGTTTATATGAATTTTGAATATTAGGAAATAATCTTGGAAGCTATATTAGTTTTCTAAAGCTATTATAACAAATTACCACAGATGGAGTGCCTCAAAACAACAGAATTTTACTCTCTTACAGTTTCAGAGACCAAACATCTGAAATCAAGTGGTTTGCAGCGTTGGCTCCTTCTGGAGGCTGGAAGGAGCATCTGTTCCATGCCTTTCTCCTAGCTTCCCATGACTGCCAGCCACCCTTGGAATTTCTTGGCTTTTATCTTAGTCAGTCTAATCTCTGCCTCTGTCTTTCCATCTCCTTCTCTGTGGGTGTTCCTTCTCCCCTTCTGTTTTGTAAGGATAGGCCTGTCATTGGATTTAAGGCCCACCTTAATCCAAGATGATCTCATTTTAAGATGTGGGACTTAATCACATTTGCGAAGACCCTTTTTCCAAATAAGGTCGCATTCACAGATCCCTACCATTCAACTCACTATGGAAGCAATGGGATGGGAGGTACCATTCAACTCACAGATTCCTACCATTCAACCCACTATAAAGCAGTGGCATATGAAAAGGATGGGAGGTTGCTATGGGAATGGTCTGCCCCAGATGCAGGTAAAATGGGGAAGCATTTTATATAGAATGGAAAAACAACAGTAAAGCTGGCTAAAACTTGATCTGCTTTTTACAGTCATGTGCTGACAATTCTAAACATTATCAATGATAAAATACTTCTCCCTCATGATATTAACTGTGCAATTTTTGCTGCCCCTGCTACATACATGCTTTATTGCTTGGAAACAGGATTACTTGGTGAAATAATGTGAATCTTTCAATTCTCATGATACATGTTTTCAACTTAATATCCAGGGTGCAGGAATATATATTCCCACCAACTTTATACAAGATAATACAAATATAATAGTATGAATAAATATGCTAATTTGATAGAAAATATTTTAATATTTACTACTAGTGTAGTTGGACGTGTTAAATATTGCAATGGTTATTTGTAATCTACCTTTATAAAATTTCTAATGTCTGCCACTGTTTCTGTTAGACTCTTAAGAAGATACGTGTTTGTCTCATAGATTTGTAAGAACTCTTTATATACTAAAAATATGGGGCTTCTATATGATTGCATATATTCGTCACTTTTGTTCCACTGTTTTAGAGAGCAGAAGATTTTAATTTCTATAAAGATTTTTATGTTTCCCTTTATTGCATGCCAATGTTTGTTTTTTAAAAACTTGTACGTCTTAGGCTGCGATGTGAAAAGTGTCTTTTTTTTGATTTGGAAACAGAGTCTTGCTCTGATGCCTGTAGTGGTATGATCATAGCTCATTGCAGCCCTTGAACTCCTGGGCTCAAGTAATCCTCCTATCTCAGCCTCCGAAGTAGCTGGGACTACAGCCACACACCACCACACCTGGCTCACTTTCGGGTGGTTGTTGTTGAGATGGGGTCTTGCTGTGTTGCTCAGGCTGGTTTTGAATACTGGGCTCAAGTGATTATCCTGCCTTAGCCTCCCAAAGTGCTGGAATTTCAGAGGTGAGCCACTGTGCCCAGCCTCCTGTTTTTTTTACATGTATATATATATATATATATATACACACACACACACACATATATATATACACACACACATATATATATACACACACATATATATACACATATATACACATATATATACACACATATATATATACACACACACATATATATACACACACATATATATACACACACATATATATATATACATATACACACACACACACACACACACACACACACACACACACACATATATTTTTTTTTTCTTTTAGATGGAGTGTCTCTCTGTTGCCCAGGCTGGGGTGCAGTGACATGATCTCTGCTCACTACAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTGCCACCACGCTGGGCTAACTTTTGTATTTTTAGTAGAGATGGGGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTTCTGACCTCGTGATTTGCCTGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCGCCATGCCTGCCCTTATTTTTATATATCTTCCATAACCTTTCTATCTCTTTCTTTCTCTTTCTCTGTTTCTGTGTGTGTCTGTGTCTGATAATAAAATACATTAAATTTTATTTTATAACATAAATGTTTTATAAGGTCGGTAGATTTGTTTATGATTTTAATGGCTGCATAGTATTCTATCATATGGATATATTCTAAATGTAATAATTCCTCAATGGTATATTTAGTTTACTTTATATTTGCTGCTTTAGTTTGTCACAAACACCGTGGATAGCCTTGTATATATTTATTTTGTTGTATAGTTCTTATTGGTACAGTATGATTTTTCACAAGTATACAATTACTTTCTGAGAATTTAGCTTTTTGATTCACGTGAAAGCCTTACTTGTATTGTTAACAATTTTGTTACGTTTGTGAGGCCTAGGCAGAAGGATTGCTTGAGACCAGGAACTCAAGACCACCTTGACCACCTTGGGCAACATAGGGGGAGCCCATCTCTACAAAAATAAAAAATAAGAAATAAAATAGCCATGCATGGTGGTGTGCCCCTGTAGTCCCAGTTACTCGGGAGGCTAAGGTGGAAGGATCGTCTGAGCCTGGGAGTTTGAGACTGCAGTGAGTTATGACCACACCACTGCACTCCAGCCTGGATGACAGAGAAAGATCTTGTCAAAAAAAAAAAAAAAATTAAATATATACAAAATAAGGGAGAATACTATGACAGGCTTCCACTTACCTATCTTTAGGCTTCTTTATAAAATGTTCATTTAATCTGATCTCTATAAGAAATTCTGTATCCTTAAACAACATGTGCCCTTCTCTTTACACAGAGCGATTACCCCCTTGCTATGTTTTATTAACAGCTAGCAAGTGCTGGGTCCTGTGTCAGTTGTTTTGTTTTTTCTTTTTCTTTGTTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTGTTTTTTTTTTTTTTGGAGATAGAGTCTTGCTCTGTTGGTCAGGCTGGAGTGCAGTGGCATGATCTTAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCGGCCTCAGCCTCCTGAGTAACTGGGATTACAGACATATACCACCACACCTGGCTAATTTTTTTTGTGTTTTGACAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTAAAATGGTCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCCGCGCCTGGCCCTGTGTCAGCCTTTTTAACAGCATAATTTTTCCTTTATTAGTCATAACTACTTTAAGGGCTATTTTGATTTACAGACAAAGTGAGACTTGGATGAATTAAGAAAGAATTAATCAGGTGGTTGAACCTGAGTTCCAACTAGGGTGACAACTCTTCGCAGATTGCCTGCTGCTGTCCTGGTTTTCACACTGAAAGTTCCGTATCCTAATAAGCCTCTCATCCTCAGCAACGGAGGACAGTTGCCCACTCAAAGCCTTGTGACATTCTAGGGTATCCTATTTCTACATGGTGGGAATCTAGAAGACGGAGAAAGAATTTCTCATTCCCGAAGGAGCATGGATTATCCTTGGTTGTAGTGTTTATGTCCACATCACGTGGATTCCCGAAGGAGCATGGATTATCCTTGGTTGTAGTGTTTATGTCCACATCACATGGGATATTTTATTTTTCAGGCCTCTTCATGTGCTTGTGTGCAACGCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTCCAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGGTGGGTTTGAATTGCATATTTGTTCACTTATCCCCTTTCTCATACCAGCTAATATTCCCCCAAGGCTCTCATTCTGAAAATAATTTTCATTAGTCCTGCTTGAGACATGTGGGTGGACTCAGCTTGGCTCACTTAATTTTTCCAGGTCTTTTTTGTTCGCCTGTGATTGTGGGGGACTGTTTAGAAGGACTTTCTAGAGCAAGGAAGATTGTTTTTACGACTATACTTCAAGCTCCTCATTGATTTTGCTTAGAGATGGAATAATAATTGATGAAATCTGAATGGCATGACCTTTATTGATTTGTAATTCAACAACTTCAACATCTTACCAAGAAGAATGTGCAGTTATTCTAGCAGGAGAAACAATGCAATTAGAGCCTGCGAGATGAAATCAAATTGTTTTATAATGAGAAATTAGGGAATTCGAGGCAGACATTAGCTGTGTAATTGTGGAAAGGGAAGAACTGTAGTTAGAGCATATTAGAAATCTGGCCGTGCCTCTTTTGGTTAAAATTTCAATTAAAACATCAGATGGCACTTTTTTCCTATTGCCATTAGGAGAATATTCAATTGACTGAAAAGGACATTTGAAAATTTCCTCGTATTTTCAGCATATTTGTTTCTAGAGTTGGAGAAACAACTATTTGTCTAGAGAGAAGTACTCTGAAAAGACAAAGGCCTTGCTGGGTGAGGCTGGATTTAATACATGTTAGGGAGATTTCTCTTTCACGTTTGCTTGGTGTGTGTTTGGCGGGGGGAACTTACACTCTTAGCAAAGTAGCTAGAAAAAAAAATAACGTGCAAGGGGCCTATTTTTTCCTCCTTCTTCTCCGTCTTAAGTCCTGAAATGTTTTAGTGACCCAGAATGAAGCTTATTTTTTTAATCATACTTCCATAAAATGTAACCCCTGGGACTTGGAAGAGAGAGACCAGCCAAGGGTTAGCTTGAACCCTTTATCACTCCCAAACACAGGGGCTTATGGTATAAGTGACACACTGCAGATAGATTTACTTTTGCCATTTTAAATTTATGATGGCTGAAATGAAAGGTAAATGCCAGTAATAATCCTCCCCCGTGTTAAAAGACATGAAACATCTAGTAATTAGGTGGTAACAAAATCTGGACAGCCTTATCTTTGCAAATCACACCAGGTTTGTGAAGGAAAGTGGAGTGGCCCTGTTAAGGGGCGAGGGAGGCTACTGTGGGGGCAGGCAGCAGAGAGAGCTCCAGAAATAAATCTGCCAGCCCCAGTCATCCACCAGATGTGGAGGGCACCACGGGATATGTTTAAATGAGCTGGTATTTAATGGGAGATTATGTCGAATTGTCAGCTGCTCACTCTCCTTGTAAATCTGTATCTCAAATGGTATTTCGTGTGACGTCTTTGTTCTTTGCTTAACTACGGTGTAATTCATGCCTACTTCAGAGATCCAAATCTCAGCATCATTTAAAAGATTAGTTTGAAAGGAAGGGACTTGGGCTCTTGAATTAGACCTATGTTAGTTTATAGGGAGGCCTTCCTGAAATGTGTTGTCAGGCTTGCTCCTGTGTGATGGCTGGCACTGGTTTTATGCTTTCCAATTATTCTTTGCACATCGTTATTTATTATTACTGTTATTATTATTTGACATGGAGTCTTGATCTGTTACCAGGCTGCAGTGCAGTGGCATGATCTCGGCTCACCACAACTTCAGACTCCCAGGGTTAAGCGATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGACCACAGGCGCTTGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTTGTGATCCGCCTGCCTTGGCTTCTCACAGTGCTGTGATTACAGGCGTGAGCCACCACGCCCGGCCTCTTTGCACATTATTTAAGGGTGTTTTAACAAAATGGCAATTTCCCCAGGCTGGCTTGTGTATTACCTTCGCATTGCATCCCTTGGCTCCCATGAGTGAGCGTGGTGACTTGGTGCGTAGGTGGTACGTGAAGACAGTTGCTCACTACCCAAGAACTCAGGGCCCTAAACCATGCTGTAAAATGCAAGTGCTGATATCTAATTACCTCCATCAACCTTGGCAGAATCTCTTCGTTGGAGTTAAGACCCCCTGTTAGGGGAAAAAAGAAAGTCCTATGTTTGCAGAAAATATTATACTAGACTGCTCCAAGGCAAAATATTTATTAGCCTTCCTGTGTCTTCACTGTGTTTTAGTTACTTATCTGGAATCTGAGCAACTGAATTGAGTTTCTGCATACCTAAAATACATCATAGTGAAATGAGAAGTTGACTTCTTTGCTGTGAAAAAATTTCAGATAACAATTAAAGTAGAATGAAAAGAGCAGAGTGCTGGTTGAACAACCCTCAATGGCTGCAGCTGCATGGAGTGCCAAATTGCCCTCCCCCACCCCACACACAAAATCACACATACACGCACGCACGCACACACACACACACGGAGTTTCTCAGCTTCTGTGTAGACAGAATCCAGCCTAATTATTTTAGGCGGGAATTTTAAAAATCCTCAATAAAATTGGGCTTGGTAGCACATGCCTGTAATCCTATCTAGTAAGAGGCTGAGGTGGGAGGATGGCTTGAGCCCAGGAGTTTGAGGTTGCGGTAAGCGTTGATCATGCCACTGCATTCCAGCCTGGGTGACAGAGTGAGACCCCATCTCTAAAATAAAAATTAAAAATTGTTTAAAAAAAATGCAGTATAGGCCAGGCACAGTGTCTCACGCCTGTAATCCCAGCACTCAAGAGTTCGAGATCAGCCTAGCCAGCATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTGCACGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTTGGGAGGTGGAGATTGCAGTGAGTGGAGATTGCACCAGTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTTTCAGAAAACAAAAACCCAAAAAGCAAAACCCCCACAGTATATATAGAAATACAAGATTTGTGAGGGGCGGGGGTCCCCCTACAAAGCAAGTGTTACTGTCCACAGAGCAAATGTCAATATTTTAATGTACTAGTAAGGGAAAATTCTATTAAGACATAATTGTTTGGCTTTGTCAGTTTGTCAACTTGAAAATAGAGTCAGCAGCATCTAAAGAGTTGTTTTACTACCTCTGGAGCTGAGAGGTGAACATAGTCGTTTTTCAGGAAGCCGTTTCTGGCTCAGACAGATAAGAAGCTGGCCCACCCTTGCCACTTCCTGGAGGACTGTCAGTGCTAGCTAATGAGACTGTAAAAGTGGACTATCTGCCCAGGAGACAGTGAGGAAGGAAATCAGGGGTCACCCTTACAGGGAAGGGCTCTTTGCAGAGAGAGTGCCTGATACGTAGCAGCTGGTACTTCTCCATCTTGAAACTGTCCTTCCTGGTTTTGTCTAATTTGTCATCATGGGATTCTTTTGACTTGTTTCTAGATTAGGGATCAAGAAGAAATGACTTTCTCCTCTTAGACATTTAATTCACTTAGTGTTCCCTAGTCATGACATACTTCTGTGTTATCCTTAAATACTGAAACAGGGACCTTATTCTTAACAGTAGAAAATCACTGTGTATGATGATAGTGTATACCTGTAATACCAGCTACTCAGGAAGCTGAGGCAGGAGGATCCCTTGAGCTCAGGAGTTGAGATTAGCATGGGCAACAAAGCAAGACCTTGTCTCTAAAAGAATAAGCAGAAACCAAAAGCCCTAAACATGAGGAAATTCCACATGTAAACATTAATGGAAAACATAGAAGAGTTGAACCTAGTGGTAAATTTTACCTTTAGAGCAATGCTTGAAACAAGGGAAACTGTCAAATTCTCATCATGGGATTTGTGTTCCTTTGTTTTTTTTATTAAGGACTTGGTCCTTGGATTGGAATTCCAAACCCATGACCAAACTGTAATCATCTAATTCTGTATTGAGTCCTTACTATGTGTCAGGCACTGTAGTAAGCAACACTCAAGAATCTTACAGTCTACTTTCCAAGAATTCACAGTCTAGTTTTGGAATCAGGTGATCAATTGACTTACAGTCTGGTATGGTGATGACAGAGGAGCAATGTACAGATAGAACAGAAGGATGGCACAGTGAGCCTTTTCACCAATCTTGGAAGGCCAGTAATGTCAGTGAACACTAGGAATGGTGTCATGGCCTGGGTCCTGAAGAGTGGATACTTAATGTCCATGGAGGCATGCATTTTTATCTGCCTTGCATGGCTTCTTTCATTCTCTCCCTGACTTCCACCCAAAAAATCACCATGATATCCAGCTGTGGAAGAGTTCATTATGGAGAGCTTCCTGGAAGAAGTAGTCCCTGAACTGGGTTGGGCTAAACAAATATGCCAAGAAGGGTTTCTGGAAGCAGTTGACAAAAGATGAGTAGAGAGAGGGAGGGGGTGGTGCTATATTTATTCCATACCTTTCAGATACTCTCTAAATCCTTGTCCCTGTTGTCTATGCCATGTAGGTAGAGTTTTCAAGTCATGTCCCATACCTTGGATCATTGGATTCTCAACTCAGTAGCACCTTTGTGTGACACCTCTTCTGTAATACCTTATTATGTTGAAATAAAGTTAGCAAATAACATAACTTACATGCACAAATATATTTTCAATTCGATATGATAGCTTTACTGTAATGAAAGAAAAAATAACTGAAACAAAATGGCGTGTGTTTCAACATGTAAATGCTTGGGCCAGGCTACAGGAAAGATGGGGATGTATGTATCCGTGGATGAATCACCTTGAATGGACTCTCATAAAAAAGCCCACCATTACCAGGTGTGTGGTATTGCAGACTCCAGCACCACCAACCTTGAGTGAAGCCTGACTATATTAGTCTGTTCTCATGCTGCTAAGAAAGACATACCCGAGACCGGGTAATTTATAAAGGAAACAGGTTTAATGGGCTCACAGTTACACATGGCTGGGGAGGCCTCACAATCATGGCGGAAGATGAAGGAAGGGCAAAGGGATGTCTTACATGACATCAGGCAACAGAGTATGTGCAGGGGAATTCTCATTTATAAAACCATCAGATTTCGTGAGACTTATTCACTACCATGAGAACAGTATGGGAGAAAGCACCCCCATGATTCACTTATCTCCACCTGGCTCTGCCCTTGACACATGGGGGTTATTACAATTCAGTGTGAGATTTGGGTGGGGACACAGCCGAACCGTATCAGTCACCCTCCAAAAATCACACAAAATCTGAAAGTGCTTTTATTCATTCTACATGTAAATAGTTGTTGCACTACCCACCTGGAAATTCAGTGGATGTTTCTAGGCTCAGATAATTATCCACAGGCTTTTCATCTCCATGAGTGTCCACTGGGGCATTCTTCATTGAGCAATACATCATGTGCATTGCAAGACATCTGCCATCCCTGCTACCATCACCAGCAGTCATCACGACAACCAGAAGAAGGCCGTCATATATTTTCAAATTGCCTGCTGAGTTCCATTGCCTTAGACAATTAAGCTTGGAAGTCAGACTCTTCCTGTGGTTTGGGTACTAGAAAAAAGGCAGCCAACAATTCGTTTCAAGGTCTCATTTCTGTATCCTTGATGACGTTTCTGGCCATCAGCTTTGTTGATGACTTTAGAGCAGCTATGTCATTTAACACTAGAAATTGGATGTCACCGAGTCCTGTGGAAGGGATATTTAATTTCCATTAAAACATGAATTTCATTCTGCCCTTGCCATGCTTTTCTTGGTCTTAGCCCAACCTGAGCTGCTGATATTAAGGAATAATAGGATAATTCCATAATTTTCATTTTACCTTTTGCTTTTTGTTTTCCATAGCAGTTATCTAGAGGATTCCCATTATGCTTCTTCATTACCCGGTGCCCAGAATGAACTTATAGAAGCAGAATATGAGGGGTCCTTTGACAAACATGAGACTGTTTAGAAAATTCCTTTTGTTTGCTGTGATCCATTTTGTAAGGGAAGTCACTATAATGTTGTTATTTAAGAGAAAGAGACAAACGGAAAGAAACAAACAGCTGGTGTTTAACGACTCCGTCAGACCCAATTATAAAGCATCAACTAGTTACGTTGATTTGTGTACATCCATGCCATGGGTATACTTAAAAACATTAGATTTTGCCAGAACTCATCTTGGCTTTGTTTACATTTTTCTTTTAAACGTATAAGACTATTGATGGTACCTCACCAAGGTTATAACCCCTTTATAATCATTAATTTTTAATCTAGAAAAGAGTCTTGGAGACAACAAGACTCATCTATAATTTCTTGGATGCTCAAATGAAAATATACAGGACTCAAGCATTAGCTAAAATAATCCAGGAAAGCCCTGTCAAAGGTTAGGAATGTGATATCTTTCTGTTTCCAAAAGCAGCAGCCCTTTATTCAAGACACTTTTCTGTTTAATTTAATTATCTTTGAACTTCCTGTTGAAGGTTTTGAAAAATATATGTTAGAGGGTGGGGAGAGAGTTCAGTATGTCAGGACTGCTACATTTATGAGTGTGGGTCTTTATTGAAGTCTCTCTTTGTAGCCAATCCTTTTTTTTTTTTTAATTTTTAAATTTTAAATTCTTACTTTTAGATATGGGGGTCTCACTCTGTTGCCCAGGCTAGAGTTCAGTGGCACAATCATAGCTCACTGCAACGTTGACCTCCCAGGCTGAAGCGATCCTCCTGCCTCAGCCCCCCAAGTAGCTGGGACCACAGGCATGTGCCAAAATACTCAACTAATTGTTTATTTTTTGTAGACATGGTGTCTCCCTATGTTGCCTAAGCTGGTCTTGAACTCCTACACTCAAGCAATCCTCCCGCCTCAGCTTCCTAAAGTGCTGGGATTAGAGGCATGAGCCACCAGACATGACCTGTGTTTATATTGTTAAATCACCATTGTCAATCTTGAAAGGAGACTTTGTTTTGATGTATGTAAGATTGAGTTTTTACTCATCTCTACATAGTTTCCTCAGATTGCTTTTTTTTTTTTTTGAGACCGAGTCTAGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTTTGCTCACTGCAACCTCTGCCTCCCATGTTTCAGTGATTCTCTTGCTTCAGATTCCCGTGTACAGGCATGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGCATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCCGACCTCAGGTGATCCACTCGTCTAAGACTCCCAAAGTGCTCGGATTACAGATGTGAGCCACTGCACCCAGCATTCCTTAGATTTCCAATAAAAATAAAAAGCTGTGTGGGAAGTCAGAACTTGGTTGCTTCATGTCATATTTCCTATTTTTAAGATTTACAGATATTAACGACTCCTTGGGAAAACTGGACTTCAGTCGCCTCTCTCCAACAAAAAACGACTATTGGGCGATGCTGGCTTATAACAGGTCCAAGCTCTGCAACATCCTCTTCTCCAACGAGCTGCACCGTCGCCTCTCCCCACGCGGGGTCACGTCGAACGCAGTGCATCCTGGAAATATGATGTACTCCAACATTCATCGCAGCTGGTGGGTGTACACACTGCTGTTTACCTTGGCGAGGCCTTTCACCAAGTCCAT"
-                },
                 "moleculeContext": "genomic",
+                "structuralType": {
+                  "id": "SO:1000037",
+                  "label": "chromosomal_duplication"
+                },
                 "allelicState": {
                   "id": "GENO:0000135",
                   "label": "heterozygous"
@@ -276,7 +264,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.209582090Z",
+    "created": "2025-01-12T18:25:29.419407129Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_30356099_Patient10.json b/notebooks/WWOX/phenopackets/PMID_30356099_Patient10.json
index 8cadd554..7d9feede 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient10.json
+++ b/notebooks/WWOX/phenopackets/PMID_30356099_Patient10.json
@@ -257,7 +257,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.215719938Z",
+    "created": "2025-01-12T18:25:29.427912950Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_30356099_Patient11.json b/notebooks/WWOX/phenopackets/PMID_30356099_Patient11.json
index d464ddc6..42da5d3b 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient11.json
+++ b/notebooks/WWOX/phenopackets/PMID_30356099_Patient11.json
@@ -292,7 +292,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.216702938Z",
+    "created": "2025-01-12T18:25:29.428873062Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_30356099_Patient12.json b/notebooks/WWOX/phenopackets/PMID_30356099_Patient12.json
index 8d17160e..502831ca 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient12.json
+++ b/notebooks/WWOX/phenopackets/PMID_30356099_Patient12.json
@@ -261,7 +261,7 @@
     }
   ],
   "metaData": {
-    "created": "2024-11-12T08:05:52.217768907Z",
+    "created": "2025-01-12T18:25:29.429977178Z",
     "createdBy": "ORCID:0000-0002-0736-9199",
     "resources": [
       {
diff --git a/notebooks/WWOX/phenopackets/PMID_30356099_Patient13.json b/notebooks/WWOX/phenopackets/PMID_30356099_Patient13.json
index 2032f535..f35dc64b 100644
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index f1caa475..2f340455 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient14.json
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index 026cd4ed..cd1fa025 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient15.json
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index 4e57f31f..4440ed4e 100644
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index 8b1ce9e7..3849c667 100644
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index f9935931..8ea6c6ad 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient18.json
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@@ -283,7 +283,7 @@
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index 295c817c..d3e27bfc 100644
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index b2308991..998b0545 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient2.json
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index 7d6300c6..5554b1cb 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient20.json
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@@ -253,7 +253,7 @@
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index f1d70573..bb78b907 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient3.json
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index 9dd2d2c4..25a5453f 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient4.json
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@@ -277,7 +277,7 @@
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index 02ae7705..d5cbd336 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient5.json
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@@ -258,7 +258,7 @@
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index dccd9e4f..a1bf4cbb 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient6.json
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@@ -274,7 +274,7 @@
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index 1fbe1d43..ee1f7ab5 100644
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@@ -255,7 +255,7 @@
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index 63d9b15a..433d01f8 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient8.json
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@@ -293,7 +293,7 @@
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index 318455ca..eab7d55e 100644
--- a/notebooks/WWOX/phenopackets/PMID_30356099_Patient9.json
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@@ -278,7 +278,7 @@
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index f3e0328a..09c064d2 100644
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index d505dd03..6c86f6f3 100644
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index 536b73f2..a3f1451f 100644
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