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<!DOCTYPE html>
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<p><strong>Title:</strong> The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis</p>
<p><strong>Year Published:</strong> 2011</p>
<p><strong>Observation:</strong> Trial for dexapramipexole. Attenuation of 20.5% in rate of decline of ALSFRS-R scores for the 300mn group relative to the 50mg group. 68% reduction in hazard of mortality for 300mg group relative to 50mg group</p>
<p><strong>Comment:</strong> Dexpramipexole was safe and well tolerated</p>
<p><strong>Citation:</strong> Cudkowicz, M., Bozik, M. E., Ingersoll, E. W., Miller, R., Mitsumoto, H., Shefner, J., … Gribkoff, V. K. (2011). The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nature Medicine, 17(12), 1652–6. doi:10.1038/nm.2579</p>
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