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17.html
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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
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<title>ALS Compendium</title>
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<h1 class="page-header">ALS Compendium
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<p><strong>Title:</strong> Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis</p>
<p><strong>Year Published:</strong> 2013</p>
<p><strong>Observation:</strong> NG2+ cells in SOD1 mice display abnormal behavior in ventral gray matter before manifestation of disease. Pathological alterations to oligodendrocytes are widespread by the time mice begin to show symptoms. Mutant SOD1 deletion from oligodendroglia reduced disease</p>
<p><strong>Comment:</strong> Removal of mutant SOD1 from oligodendroglia delayed disease onset and prolonged survival in ALS mice</p>
<p><strong>Citation:</strong> Kang, S. H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D. W., Ostrow, L. W., … Bergles, D. E. (2013). Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nature Publishing Group, 16(5), 571–579. doi:10.1038/nn.3357</p>
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