diff --git a/docs/CHANGELOG.rst b/docs/CHANGELOG.rst
index dff9b43aa..e3b79a96d 100644
--- a/docs/CHANGELOG.rst
+++ b/docs/CHANGELOG.rst
@@ -16,6 +16,7 @@ Added
 
 Changed
 -------
+- **BACKWARD INCOMPATIBLE:** Require Resolwe 42.x
 
 Fixed
 -----
diff --git a/setup.py b/setup.py
index 019a89e24..c4cc892a6 100644
--- a/setup.py
+++ b/setup.py
@@ -45,7 +45,7 @@
         "djangorestframework~=3.15.2",
         "django-filter~=24.2",
         # XXX: Required due to issue https://github.com/pypa/pip/issues/4905.
-        "resolwe >=41.0a1, ==41.*",
+        "resolwe >=42.0a1, ==42.*",
         "wrapt~=1.16.0",
     ),
     extras_require={