diff --git a/.github/workflows/pythonapp.yml b/.github/workflows/pythonapp.yml
index b8b73907d4..d1e77bb567 100644
--- a/.github/workflows/pythonapp.yml
+++ b/.github/workflows/pythonapp.yml
@@ -100,6 +100,7 @@ jobs:
         python -m pip install --pre -U itk
     - name: Install the dependencies
       run: |
+        python -m pip install --user --upgrade pip wheel
         python -m pip install torch==1.13.1 torchvision==0.14.1
         cat "requirements-dev.txt"
         python -m pip install -r requirements-dev.txt
diff --git a/docs/requirements.txt b/docs/requirements.txt
index 5acc437391..468545dc19 100644
--- a/docs/requirements.txt
+++ b/docs/requirements.txt
@@ -22,7 +22,7 @@ sphinx-autodoc-typehints==1.11.1
 pandas
 einops
 transformers<4.22; python_version <= '3.10'  # https://github.com/Project-MONAI/MONAI/issues/5157
-mlflow>=1.28.0, <=2.11.3
+mlflow>=2.12.2
 clearml>=1.10.0rc0
 tensorboardX
 imagecodecs; platform_system == "Linux" or platform_system == "Darwin"
diff --git a/requirements-dev.txt b/requirements-dev.txt
index e8792c86f3..83bdae2a5c 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -34,7 +34,7 @@ pandas
 requests
 einops
 transformers>=4.36.0
-mlflow>=1.28.0, <=2.11.3
+mlflow>=2.12.2
 clearml>=1.10.0rc0
 matplotlib!=3.5.0
 tensorboardX
diff --git a/setup.cfg b/setup.cfg
index c8ae1630f7..711d5c5558 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -66,7 +66,7 @@ all =
     pandas
     einops
     transformers<4.22; python_version <= '3.10'
-    mlflow>=1.28.0, <=2.11.3
+    mlflow>=2.12.2
     clearml>=1.10.0rc0
     matplotlib
     tensorboardX
@@ -125,7 +125,7 @@ einops =
 transformers =
     transformers<4.22; python_version <= '3.10'
 mlflow =
-    mlflow>=1.28.0, <=2.11.3
+    mlflow>=2.12.2
 matplotlib =
     matplotlib
 clearml =