diff --git a/browser/ntp_background/custom_background_file_manager_browsertest.cc b/browser/ntp_background/custom_background_file_manager_browsertest.cc
index e5d2c48bbf7d..3bdd909706a9 100644
--- a/browser/ntp_background/custom_background_file_manager_browsertest.cc
+++ b/browser/ntp_background/custom_background_file_manager_browsertest.cc
@@ -15,6 +15,7 @@
 #include "base/threading/thread_restrictions.h"
 #include "brave/browser/ntp_background/constants.h"
 #include "brave/components/constants/brave_paths.h"
+#include "build/build_config.h"
 #include "chrome/browser/profiles/profile.h"
 #include "chrome/browser/ui/browser.h"
 #include "chrome/test/base/in_process_browser_test.h"
@@ -111,8 +112,16 @@ IN_PROC_BROWSER_TEST_F(CustomBackgroundFileManagerBrowserTest,
   EXPECT_TRUE(base::PathExists(test_file()));
 }
 
+// On Mac x64 CI node we presume this test crashes the whole suite.
+// https://github.com/brave/brave-browser/issues/38988
+#if BUILDFLAG(IS_MAC) && defined(ARCH_CPU_ARM_FAMILY)
+#define MAYBE_SaveImageMultipleTimes SaveImageMultipleTimes
+#else
+#define MAYBE_SaveImageMultipleTimes DISABLED_SaveImageMultipleTimes
+#endif
+
 IN_PROC_BROWSER_TEST_F(CustomBackgroundFileManagerBrowserTest,
-                       SaveImageMultipleTimes) {
+                       MAYBE_SaveImageMultipleTimes) {
   for (int i = 0; i < 3; i++) {
     base::RunLoop run_loop;
     base::FilePath expected_path =