diff --git a/cmake/yacma/YACMACompilerLinkerSettings.cmake b/cmake/yacma/YACMACompilerLinkerSettings.cmake
index 3d9cd9dab..e56321846 100644
--- a/cmake/yacma/YACMACompilerLinkerSettings.cmake
+++ b/cmake/yacma/YACMACompilerLinkerSettings.cmake
@@ -125,6 +125,18 @@ if(NOT _YACMACompilerLinkerSettingsRun)
         _YACMA_CHECK_ENABLE_DEBUG_CXX_FLAG(-Warray-bounds-pointer-arithmetic)
         # New warnings in clang 14.
         _YACMA_CHECK_ENABLE_DEBUG_CXX_FLAG(-Warray-parameter)
+        # NOTE: clang 17 enables by default a new compiler flag called "-fassume-unique-vtables":
+        #
+        # https://releases.llvm.org/17.0.1/tools/clang/docs/ReleaseNotes.html#c-language-changes
+        #
+        # This flag however seems to be buggy:
+        #
+        # https://github.com/llvm/llvm-project/issues/71196
+        #
+        # On our part, in several projects we are experiencing Boost.serialization failures when
+        # (de)serialising derived objects through pointers to bases. Thus, we forcibly disable
+        # this new flag.
+        _YACMA_CHECK_ENABLE_CXX_FLAG(-fno-assume-unique-vtables)
     endif()
 
     # Common configuration for GCC, clang and Intel.
diff --git a/doc/changelog.rst b/doc/changelog.rst
index 169c872b6..c853c70cc 100644
--- a/doc/changelog.rst
+++ b/doc/changelog.rst
@@ -1,6 +1,16 @@
 Changelog
 =========
 
+6.0.1 (unreleased)
+------------------
+
+Fix
+~~~
+
+- Workaround for a clang 17 issue that would result in
+  runtime exceptions during (de)serialisation
+  (`#458 <https://github.com/bluescarni/heyoka/pull/458>`__).
+
 6.0.0 (2024-09-21)
 ------------------
 
diff --git a/tools/gha_osx_arm64_static.sh b/tools/gha_osx_arm64_static.sh
index 57250fa7d..49e9e6649 100644
--- a/tools/gha_osx_arm64_static.sh
+++ b/tools/gha_osx_arm64_static.sh
@@ -11,7 +11,7 @@ wget https://github.com/conda-forge/miniforge/releases/latest/download/Miniforge
 export deps_dir=$HOME/local
 export PATH="$HOME/miniconda/bin:$PATH"
 bash miniconda.sh -b -p $HOME/miniconda
-conda create -y -p $deps_dir 'c-compiler<1.8' zlib 'cxx-compiler<1.8' libcxx cmake ninja \
+conda create -y -p $deps_dir c-compiler zlib cxx-compiler libcxx cmake ninja \
     llvmdev tbb-devel tbb libboost-devel sleef xtensor xtensor-blas blas \
     blas-devel fmt spdlog 'mppp=1.*'
 source activate $deps_dir
diff --git a/tools/gha_osx_x86.sh b/tools/gha_osx_x86.sh
index 40e2db1c0..9029937e3 100644
--- a/tools/gha_osx_x86.sh
+++ b/tools/gha_osx_x86.sh
@@ -11,7 +11,7 @@ wget https://github.com/conda-forge/miniforge/releases/latest/download/Miniforge
 export deps_dir=$HOME/local
 export PATH="$HOME/miniconda/bin:$PATH"
 bash miniconda.sh -b -p $HOME/miniconda
-conda create -y -p $deps_dir 'c-compiler<1.8' zlib 'cxx-compiler<1.8' libcxx cmake ninja \
+conda create -y -p $deps_dir c-compiler zlib cxx-compiler libcxx cmake ninja \
     llvmdev tbb-devel tbb libboost-devel sleef xtensor xtensor-blas blas \
     blas-devel fmt spdlog 'mppp=1.*'
 source activate $deps_dir
@@ -25,7 +25,7 @@ unset CXXFLAGS
 unset CFLAGS
 
 # Configure.
-CXX=clang++ CC=clang cmake ../ -G Ninja \
+CXX=clang++ CC=clang cmake -G Ninja ../ \
     -DCMAKE_PREFIX_PATH=$deps_dir \
     -DCMAKE_BUILD_TYPE=Debug \
     -DHEYOKA_BUILD_TESTS=yes \
diff --git a/tools/gha_osx_x86_static.sh b/tools/gha_osx_x86_static.sh
index c7e8e6333..497b3bad9 100644
--- a/tools/gha_osx_x86_static.sh
+++ b/tools/gha_osx_x86_static.sh
@@ -11,7 +11,7 @@ wget https://github.com/conda-forge/miniforge/releases/latest/download/Miniforge
 export deps_dir=$HOME/local
 export PATH="$HOME/miniconda/bin:$PATH"
 bash miniconda.sh -b -p $HOME/miniconda
-conda create -y -p $deps_dir 'c-compiler<1.8' zlib 'cxx-compiler<1.8' libcxx cmake ninja \
+conda create -y -p $deps_dir c-compiler zlib cxx-compiler libcxx cmake ninja \
     llvmdev tbb-devel tbb libboost-devel sleef xtensor xtensor-blas blas \
     blas-devel fmt spdlog 'mppp=1.*'
 source activate $deps_dir