Computational Methods Defining the Impact of Pregnancy-Specific Prolactin Receptor Signaling on Pancreatic Islet Gene Expression in Mice
Authors: Mark E. Pepin, PhD; Hayden H. Bickerton, BS; Maigen Bethea, BS; Chad S. Hunter, PhD; Adam R. Wende, PhD; Ronadip R. Banerjee, MD, PhD
This document summarizes the computational methods that were used to examine the contribution of prolactin receptor-mediated control of beta cell transcriptional reprogramming on metabolic adaptation to pregnancy. The Supplemental Tables (as .xlsx file) and Supplemental Figures (as .pptx file) are located in files above this document (available for download).
Before differential expression could be generated, the Affymetrix array was first pre-processed for numerous quality assessments using the oligo package in r. The raw data were first adjusted for background signal noise, as well as normalized across samples using the quantile normalization and summarization as previously described (see oligo methods).
## try http:// if https:// URLs are not supported
# source("https://bioconductor.org/biocLite.R")
# biocLite("pd.mogene.2.0.st")
# biocLite("affy")
# biocLite("limma")
# biocLite("oligo")
#biocLite("mogene20sttranscriptcluster.db")
#biocLite("mogene20stprobeset.db")
##Load all required packages
library(affy)
library(limma)
library(pd.mogene.2.0.st)
library(oligo)
library(mogene20stprobeset.db)
library(mogene20sttranscriptcluster.db)
library(openxlsx)
## import "phenotype" data, describing the experimental design
celFiles <- list.celfiles('../1_Input/Microarray', full.names=TRUE)
rawData <- read.celfiles(celFiles)## Reading in : ../1_Input/Microarray/Ronadip Banerjee_RB-C2_(MoGene-2_0-st).CEL
## Reading in : ../1_Input/Microarray/Ronadip Banerjee_RB-C3_(MoGene-2_0-st).CEL
## Reading in : ../1_Input/Microarray/Ronadip Banerjee_RB-C4_(MoGene-2_0-st).CEL
## Reading in : ../1_Input/Microarray/Ronadip Banerjee_RB-KO1_(MoGene-2_0-st).CEL
## Reading in : ../1_Input/Microarray/Ronadip Banerjee_RB-KO3_(MoGene-2_0-st).CEL
## Reading in : ../1_Input/Microarray/Ronadip Banerjee_RB-KO4_(MoGene-2_0-st).CEL
##MA Plot
xl <- c(2.8, 4)
yl <- c(-1, 1)
MAplot(rawData[, 1:6], pairs=TRUE, ylim=yl, xlim=xl, plotFun=plot)
pdf(file = "../2_Output/MA.Plot_bPRLRKO.pdf", height = 4, width = 6)
MAplot(rawData[, 1:6], pairs=TRUE, ylim=yl, xlim=xl, plotFun=plot)
dev.off()## quartz_off_screen
## 2
#Background and noise subtraction, with log transformation normalization
eset<-rma(rawData)## Background correcting
## Normalizing
## Calculating Expression
#add sample information
Index<-read.xlsx("../1_Input/Index.xlsx", rowNames = T)
Index.fix<-AnnotatedDataFrame(Index)
phenoData(eset)<-Index.fix
#
crma=exprs(eset)
rma=format(crma, digits=5)
rma_annotated<-merge(rma, mogene20sttranscriptclusterSYMBOL, by.x = 0, by.y = 1)
rma_annotated<-merge(rma_annotated, mogene20sttranscriptclusterENTREZID, by.x = "Row.names", by.y = 1)
rma_annotated<-dplyr::rename(rma_annotated, Affy_id = Row.names, Gene.Symbol = symbol, Entrez_id=gene_id)
rownames(rma_annotated)<-rma_annotated$Affy_id
write.table(rma_annotated, file = "rma.txt", quote = FALSE, sep = "\t", row.names = FALSE, col.names = TRUE)
#generate the design matrix
design<-model.matrix(~factor(c(0, 0, 0, 1, 1, 1)))
rownames(design)<-celFiles
colnames(design)<-c("CON", "KO")
fit <- lmFit(eset, design)
ebayes <- eBayes(fit)
lod <- -log10(ebayes[["p.value"]][,2])
mtstat<- ebayes[["t"]][,2]
tab <- topTable(ebayes, coef=2, adjust="fdr", number=nrow(ebayes))
tab$Affy_id<-rownames(tab)
table<-dplyr::inner_join(tab, rma_annotated, by="Affy_id")
results<-table
results_p05<-dplyr::filter(results, P.Value<0.05)
results_q05<-dplyr::filter(results, adj.P.Val<0.05)
#Export data as tabbed excel workbook
library(openxlsx)
wb_DESeq<-createWorkbook()
#Unfiltered
addWorksheet(wb_DESeq, "Unfiltered")
writeData(wb_DESeq, "Unfiltered", results, startCol = 1)
#P-value Significant (0.05)
addWorksheet(wb_DESeq, "P < 0.05")
writeData(wb_DESeq, "P < 0.05", results_p05, startCol = 1)
#Q-value Significant (0.05)
addWorksheet(wb_DESeq, "Q < 0.05")
writeData(wb_DESeq, "Q < 0.05", results_q05, startCol = 1)
saveWorkbook(wb_DESeq, file = "../2_Output/bPRLR.KO_Diff.EX_Results.xlsx", overwrite = TRUE)
results_ebayes<-as.data.frame(ebayes)
results_ebayes<-merge(results_ebayes, crma, by=0)#Create Q-Q plot
library(Haplin)
test<-table
test<-test[complete.cases(test),]
pQQ(test$P.Value, lim=c(0,10))
pdf(file = "../2_Output/QQ.Plot_bPRLRKO.pdf", height = 4, width = 6)
pQQ(test$P.Value, lim=c(0,10))
dev.off()## quartz_off_screen
## 2
# Load packages
library(dplyr)
library(ggplot2)
library(ggrepel)
library(openxlsx)
# Read data from the web
results<-read.xlsx("../2_Output/bPRLR.KO_Diff.EX_Results.xlsx", sheet = "Unfiltered")
results = mutate(results, sig=ifelse(results$P.Value<0.05 & abs(results$logFC)>0.585, "Q < 0.05 and |FC| > 1.5", "Not Sig"))
results = mutate(results, minuslogp=-log(P.Value))
#plot the ggplot
p = ggplot(results, aes(logFC, minuslogp)) + theme(panel.background = element_rect("white", colour = "black", size=2), panel.grid.major = element_line(colour = "gray50", size=.75), panel.grid.minor = element_line(colour = "gray50", size=0.4)) +
geom_point(aes(fill=sig), colour="black", shape=21) + labs(x=expression(Log[2](Fold-Change)), y=expression(-Log[10](P-value))) + xlim(-5.5,2)+ geom_hline(yintercept = 0, size = 1) + geom_vline(xintercept=0, size=1)+
scale_fill_manual(values=c("black", "tomato"))
#add a repelling effect to the text labels.
p+geom_text_repel(data=filter(results, adj.P.Val<0.01), aes(label=Gene.Symbol))
pdf(file = "../2_Output/Volcano.Plot_bPRLRKO.pdf", height = 4, width = 6)
p+geom_text_repel(data=filter(results, adj.P.Val<0.01), aes(label=Gene.Symbol))
dev.off()## quartz_off_screen
## 2
#Plot Features of the PCA
library(dplyr)
library(plotly)
##Import the data to be used for PCA
results_DEG<-dplyr::select(results, contains("Ronadip"))
results_DEG$`Ronadip.Banerjee_RB-C2_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip.Banerjee_RB-C2_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip.Banerjee_RB-C3_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip.Banerjee_RB-C3_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip.Banerjee_RB-C4_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip.Banerjee_RB-C4_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip.Banerjee_RB-KO1_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip.Banerjee_RB-KO1_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip.Banerjee_RB-KO3_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip.Banerjee_RB-KO3_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip.Banerjee_RB-KO4_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip.Banerjee_RB-KO4_(MoGene-2_0-st).CEL`))
#transpose the dataset (required for PCA)
data.pca<-t(results_DEG)
data.pca<-as.data.frame(data.pca)
##merge the file
Index<-design
rownames(Index)<-row.names(data.pca)
data.pca_Final<-merge(Index, data.pca, by=0)
rownames(data.pca_Final)<-data.pca_Final$Row.names
data.pca_Final<-dplyr::select(data.pca_Final, -Row.names)
pca.comp<-prcomp(data.pca_Final[,(ncol(Index)+1):ncol(data.pca_Final)])
pcaCharts=function(x) {
x.var <- x$sdev ^ 2
x.pvar <- x.var/sum(x.var)
par(mfrow=c(2,2))
plot(x.pvar,xlab="Principal component",
ylab="Proportion of variance", ylim=c(0,1), type='b')
plot(cumsum(x.pvar),xlab="Principal component",
ylab="Cumulative Proportion of variance",
ylim=c(0,1),
type='b')
screeplot(x)
screeplot(x,type="l")
par(mfrow=c(1,1))
}
pcaCharts(pca.comp)
write.csv(data.pca, "../2_Output/data.pca.csv")library(ggfortify)
library(cluster)
autoplot(pca.comp, data = data.pca_Final, colour = "KO")
library(pheatmap)
results_DEG<-dplyr::select(results_p05, `Ronadip Banerjee_RB-C2_(MoGene-2_0-st).CEL`:`Ronadip Banerjee_RB-KO4_(MoGene-2_0-st).CEL`)
results_DEG$`Ronadip Banerjee_RB-C2_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip Banerjee_RB-C2_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip Banerjee_RB-C3_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip Banerjee_RB-C3_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip Banerjee_RB-C4_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip Banerjee_RB-C4_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip Banerjee_RB-KO1_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip Banerjee_RB-KO1_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip Banerjee_RB-KO3_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip Banerjee_RB-KO3_(MoGene-2_0-st).CEL`))
results_DEG$`Ronadip Banerjee_RB-KO4_(MoGene-2_0-st).CEL`<-as.numeric(as.character(results_DEG$`Ronadip Banerjee_RB-KO4_(MoGene-2_0-st).CEL`))
##Index file for annotating samples
Annotation<-Index
rownames(Index)<-colnames(results_DEG)
paletteLength <- 100
myColor <- colorRampPalette(c("dodgerblue4", "white", "gold2"))(paletteLength)
pheatmap(results_DEG,
cluster_cols=T,
border_color=NA,
cluster_rows=T,
scale = 'row',
show_colnames = F,
show_rownames = F,
color = myColor)
##Create a circular genome plot of EZH2 and its targets that are Diff. Exp'd
library(dplyr)
library(openxlsx)
#Import "Links" (the PRLR_DEGGs)
Gene_Labels<-read.xlsx("../1_Input/Circos/Links_EZH2.xlsx")
#Re-order based on chromosome name
Gene_Labels<-arrange(Gene_Labels, chromStart)
Gene_Labels$chrom<-factor(Gene_Labels$chrom, levels=c("chr1", "chr2", "chr3", "chr4",
"chr5", "chr6", "chr7", "chr8",
"chr9", "chr10", "chr11", "chr12",
"chr13", "chr14", "chr15", "chr16",
"chr17", "chr18", "chr19", "chr20",
"chr21", "chr22", "chr23", "chrX",
"chrY"))
Gene_Labels<-Gene_Labels[order(Gene_Labels$chrom),]
Gene_Labels<-Gene_Labels[!duplicated(Gene_Labels[,4]),]
#Read in differential expression for lines and coloring
DiffEX_raw<-read.csv("../2_Output/Diff.EQ_ebayes.limma_180315mep.csv")
rownames(DiffEX_raw)<-DiffEX_raw$X
#Filter by EZH2 Targets
EZH2_PRLR.DEGGs<-merge(Gene_Labels, DiffEX_raw, by.x="GeneSymbol", by.y = "Symbols")
EZH2_PRLR.DEGGs<-dplyr::select(EZH2_PRLR.DEGGs, chrom, chromStart, chromEnd, logFC)
# Split for coloring (up = yellow, down = blue)
EZH2_PRLR.DEGGs_UP<-filter(EZH2_PRLR.DEGGs, logFC>0)
EZH2_PRLR.DEGGs_DOWN<-filter(EZH2_PRLR.DEGGs, logFC<0)
EZH2_PRLR.DEGGs_UP<-arrange(EZH2_PRLR.DEGGs_UP, chromStart)
EZH2_PRLR.DEGGs_UP$chrom<-factor(EZH2_PRLR.DEGGs_UP$chrom, levels=c("chr1", "chr2", "chr3", "chr4",
"chr5", "chr6", "chr7", "chr8",
"chr9", "chr10", "chr11", "chr12",
"chr13", "chr14", "chr15", "chr16",
"chr17", "chr18", "chr19", "chr20",
"chr21", "chr22", "chr23", "chrX",
"chrY"))
EZH2_PRLR.DEGGs_UP<-EZH2_PRLR.DEGGs_UP[order(EZH2_PRLR.DEGGs_UP$chrom),]
#Fold Change DOWN (RNA)
EZH2_PRLR.DEGGs_DOWN<-arrange(EZH2_PRLR.DEGGs_DOWN, chromStart)
EZH2_PRLR.DEGGs_DOWN$chrom<-factor(EZH2_PRLR.DEGGs_DOWN$chrom, levels=c("chr1", "chr2", "chr3", "chr4",
"chr5", "chr6", "chr7", "chr8",
"chr9", "chr10", "chr11", "chr12",
"chr13", "chr14", "chr15", "chr16",
"chr17", "chr18", "chr19", "chr20",
"chr21", "chr22", "chr23", "chrX",
"chrY"))
EZH2_PRLR.DEGGs_DOWN<-EZH2_PRLR.DEGGs_DOWN[order(EZH2_PRLR.DEGGs_DOWN$chrom),]
##Fold Change List
Gene_FoldChange_List<-list(EZH2_PRLR.DEGGs_UP, EZH2_PRLR.DEGGs_DOWN)
library(circlize)
library(gtools)
library(dplyr)
om = circos.par("track.margin")
oc = circos.par("cell.padding")
circos.par(track.margin = c(0, 0), cell.padding = c(0, 0, 0, 0))
circos.par(start.degree = 0)
circos.initializeWithIdeogram(track.height = 0.05)
### Labels for PRLR_DEGGs
circos.genomicLabels(Gene_Labels, labels.column=4, side='outside', cex=.8)
##DEGGs
circos.genomicTrackPlotRegion(Gene_FoldChange_List,
ylim = c(-4, 4), bg.border=NA,
panel.fun = function(region, value, ...) {
col = ifelse(value[[1]] > 0, "darkgoldenrod1", "blue")
circos.genomicPoints(region, value, col = col, cex = 0.8, pch = 16)
cell.xlim = get.cell.meta.data("cell.xlim")
for(h in c(-4, -2, 0, 2, 4)) {
circos.lines(cell.xlim, c(h, h), col ="#00000040")
}
}, track.height = 0.1)
circos.par(track.margin=om, cell.padding=oc)
## Add link for all DEGs with DMRs in promoter CGIs
Link_Anchor <- read.xlsx("../1_Input/Circos/Links_EZH2.xlsx", sheet = "Anchor")
Link<-Gene_Labels
Link<-dplyr::select(Gene_Labels, -GeneSymbol)
Link$chrom<-factor(Link$chrom, levels=c("chr1", "chr2", "chr3", "chr4",
"chr5", "chr6", "chr7", "chr8",
"chr9", "chr10", "chr11", "chr12",
"chr13", "chr14", "chr15", "chr16",
"chr17", "chr18", "chr19", "chr20",
"chr21", "chr22", "chr23", "chrX",
"chrY"))
Link<-Link[order(Link$chrom),]
Link_Anchor<-Link_Anchor[1:nrow(Link),]
circos.genomicLink(Link, Link_Anchor, col="black", lwd=0.5)
circos.clear()Based on the dataset published by Schraenen et. al 2015 (PMID), we wanted to determine whether the transcriptional changes due to PRLR-knockout were impacted by pregnancy alone. To test this, we acquired the expression data from GEO, and analyzed based on the following differential-expression analysis workflow. Because C57Bl6/J mice exhibited dysglycemia at day-30 of high-fat diet treatment, we chose to examine the time-point immediately prior to onset of dysglycemia (day 10) to minimize the confounding effects of the diabetic milieu.
## class: DESeqDataSet
## dim: 21382 12
## metadata(1): version
## assays(1): counts
## rownames(21382): 0610005C13Rik 0610007C21Rik ... Zzz3 l7Rn6
## rowData names(0):
## colnames(12): 1HF141 1HF142 ... 1RC121 1RC122
## colData names(4): Sample_ID Strain Diet Duration
## quartz_off_screen
## 2
## class: DESeqDataSet
## dim: 21382 12
## metadata(1): version
## assays(2): counts mu
## rownames(21382): 0610005C13Rik 0610007C21Rik ... Zzz3 l7Rn6
## rowData names(9): baseMean baseVar ... dispOutlier dispMAP
## colnames(12): 1HF141 1HF142 ... 1RC121 1RC122
## colData names(5): Sample_ID Strain Diet Duration sizeFactor
We then examined whether High-fat feeding and pregnancy employed overlapping transcriptional pathways for beta cell adaptation. Based on these results, we see a clear divergence in the transcriptional signature.
library(Vennerable)
library(openxlsx)
bPRLRKO<-read.xlsx("../2_Output/bPRLR.KO_Diff.EX_Results.xlsx", sheet = "Q < 0.05")
HFD.Effect_10d<-read.xlsx("../2_Output/C57Bl6J_HFD.v.NC_10days_DESeq2.xlsx", sheet = "Q < 0.05")
HFD.Effect_30d<-read.xlsx("../2_Output/C57Bl6J_HFD.v.NC_30days_DESeq2.xlsx", sheet = "Q < 0.05")
#Create a list containing gene names for each analysis
Venn.list<-list(bPRLRKO$Gene.Symbol, HFD.Effect_30d$ensembl_gene_id)
venny<-Venn(Sets=Venn.list[1:2], SetNames = c("bPRLRKO", "Bellini HFD-30d"))
plot(venny, doWeights = T)
All packages and setting are acquired using the following command:
library(kableExtra)
sinfo<-devtools::session_info()
sinfo$platform## setting value
## version R version 3.4.3 (2017-11-30)
## os macOS 10.14
## system x86_64, darwin15.6.0
## ui X11
## language (EN)
## collate en_US.UTF-8
## ctype en_US.UTF-8
## tz America/Chicago
## date 2018-10-29
sinfo$packages %>% kable(
align="c",
longtable=T,
booktabs=T,
caption="Packages and Required Dependencies") %>%
kable_styling(latex_options=c("striped", "repeat_header", "condensed"))| package | ondiskversion | loadedversion | path | loadedpath | attached | is_base | date | source | md5ok | library | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| acepack | acepack | 1.4.1 | 1.4.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/acepack | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/acepack | FALSE | FALSE | 2016-10-29 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| affxparser | affxparser | 1.50.0 | 1.50.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/affxparser | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/affxparser | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| affy | affy | 1.56.0 | 1.56.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/affy | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/affy | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| affyio | affyio | 1.48.0 | 1.48.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/affyio | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/affyio | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| annotate | annotate | 1.56.2 | 1.56.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/annotate | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/annotate | FALSE | FALSE | 2018-03-22 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| AnnotationDbi | AnnotationDbi | 1.40.0 | 1.40.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/AnnotationDbi | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/AnnotationDbi | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| assertthat | assertthat | 0.2.0 | 0.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/assertthat | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/assertthat | FALSE | FALSE | 2017-04-11 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| backports | backports | 1.1.2 | 1.1.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/backports | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/backports | FALSE | FALSE | 2017-12-13 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| base64enc | base64enc | 0.1.3 | 0.1-3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/base64enc | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/base64enc | FALSE | FALSE | 2015-07-28 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| bindr | bindr | 0.1.1 | 0.1.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bindr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bindr | FALSE | FALSE | 2018-03-13 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| bindrcpp | bindrcpp | 0.2.2 | 0.2.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bindrcpp | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bindrcpp | TRUE | FALSE | 2018-03-29 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| Biobase | Biobase | 2.38.0 | 2.38.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Biobase | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Biobase | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| BiocGenerics | BiocGenerics | 0.24.0 | 0.24.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/BiocGenerics | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/BiocGenerics | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| BiocInstaller | BiocInstaller | 1.28.0 | 1.28.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/BiocInstaller | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/BiocInstaller | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| BiocParallel | BiocParallel | 1.12.0 | 1.12.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/BiocParallel | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/BiocParallel | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| biomaRt | biomaRt | 2.34.2 | 2.34.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/biomaRt | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/biomaRt | TRUE | FALSE | 2018-01-20 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| Biostrings | Biostrings | 2.46.0 | 2.46.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Biostrings | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Biostrings | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| bit | bit | 1.1.14 | 1.1-14 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bit | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bit | FALSE | FALSE | 2018-05-29 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| bit64 | bit64 | 0.9.7 | 0.9-7 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bit64 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bit64 | FALSE | FALSE | 2017-05-08 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| bitops | bitops | 1.0.6 | 1.0-6 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bitops | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/bitops | FALSE | FALSE | 2013-08-17 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| blob | blob | 1.1.1 | 1.1.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/blob | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/blob | FALSE | FALSE | 2018-03-25 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| calibrate | calibrate | 1.7.2 | 1.7.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/calibrate | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/calibrate | TRUE | FALSE | 2013-09-10 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| callr | callr | 3.0.0 | 3.0.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/callr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/callr | FALSE | FALSE | 2018-08-24 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| checkmate | checkmate | 1.8.5 | 1.8.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/checkmate | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/checkmate | FALSE | FALSE | 2017-10-24 | CRAN (R 3.4.2) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| circlize | circlize | 0.4.4 | 0.4.4 | /Users/pepin/Library/R/3.4/library/circlize | /Users/pepin/Library/R/3.4/library/circlize | TRUE | FALSE | 2018-06-10 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| cli | cli | 1.0.1 | 1.0.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/cli | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/cli | FALSE | FALSE | 2018-09-25 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| cluster | cluster | 2.0.7.1 | 2.0.7-1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/cluster | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/cluster | TRUE | FALSE | 2018-04-09 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| codetools | codetools | 0.2.15 | 0.2-15 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/codetools | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/codetools | FALSE | FALSE | 2016-10-05 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| colorspace | colorspace | 1.3.2 | 1.3-2 | /Users/pepin/Library/R/3.4/library/colorspace | /Users/pepin/Library/R/3.4/library/colorspace | FALSE | FALSE | 2016-12-14 | CRAN (R 3.4.0) | /Users/pepin/Library/R/3.4/library | |
| crayon | crayon | 1.3.4 | 1.3.4 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/crayon | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/crayon | FALSE | FALSE | 2017-09-16 | CRAN (R 3.4.1) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| data.table | data.table | 1.11.8 | 1.11.8 | /Users/pepin/Library/R/3.4/library/data.table | /Users/pepin/Library/R/3.4/library/data.table | TRUE | FALSE | 2018-09-30 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| DBI | DBI | 1.0.0 | 1.0.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/DBI | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/DBI | TRUE | FALSE | 2018-05-02 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| debugme | debugme | 1.1.0 | 1.1.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/debugme | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/debugme | FALSE | FALSE | 2017-10-22 | CRAN (R 3.4.2) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| DelayedArray | DelayedArray | 0.4.1 | 0.4.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/DelayedArray | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/DelayedArray | TRUE | FALSE | 2017-11-07 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| desc | desc | 1.2.0 | 1.2.0 | /Users/pepin/Library/R/3.4/library/desc | /Users/pepin/Library/R/3.4/library/desc | FALSE | FALSE | 2018-05-01 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| DESeq2 | DESeq2 | 1.18.1 | 1.18.1 | /Users/pepin/Library/R/3.4/library/DESeq2 | /Users/pepin/Library/R/3.4/library/DESeq2 | TRUE | FALSE | 2017-11-12 | Bioconductor | /Users/pepin/Library/R/3.4/library | |
| devtools | devtools | 2.0.0 | 2.0.0 | /Users/pepin/Library/R/3.4/library/devtools | /Users/pepin/Library/R/3.4/library/devtools | FALSE | FALSE | 2018-10-19 | CRAN (R 3.4.3) | /Users/pepin/Library/R/3.4/library | |
| digest | digest | 0.6.18 | 0.6.18 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/digest | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/digest | FALSE | FALSE | 2018-10-10 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| dplyr | dplyr | 0.7.7 | 0.7.7 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/dplyr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/dplyr | TRUE | FALSE | 2018-10-16 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| evaluate | evaluate | 0.12 | 0.12 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/evaluate | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/evaluate | FALSE | FALSE | 2018-10-09 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| fastmatch | fastmatch | 1.1.0 | 1.1-0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/fastmatch | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/fastmatch | FALSE | FALSE | 2017-01-28 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| ff | ff | 2.2.14 | 2.2-14 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ff | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ff | FALSE | FALSE | 2018-05-15 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| ffbase | ffbase | 0.12.5 | 0.12.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ffbase | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ffbase | FALSE | FALSE | 2018-09-24 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| foreach | foreach | 1.4.4 | 1.4.4 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/foreach | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/foreach | FALSE | FALSE | 2017-12-12 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| foreign | foreign | 0.8.71 | 0.8-71 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/foreign | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/foreign | FALSE | FALSE | 2018-07-20 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| Formula | Formula | 1.2.3 | 1.2-3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Formula | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Formula | FALSE | FALSE | 2018-05-03 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| fs | fs | 1.2.6 | 1.2.6 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/fs | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/fs | FALSE | FALSE | 2018-08-23 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| genefilter | genefilter | 1.60.0 | 1.60.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/genefilter | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/genefilter | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| geneplotter | geneplotter | 1.56.0 | 1.56.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/geneplotter | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/geneplotter | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| GenomeInfoDb | GenomeInfoDb | 1.14.0 | 1.14.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/GenomeInfoDb | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/GenomeInfoDb | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| GenomeInfoDbData | GenomeInfoDbData | 1.0.0 | 1.0.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/GenomeInfoDbData | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/GenomeInfoDbData | FALSE | FALSE | 2018-02-16 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| GenomicRanges | GenomicRanges | 1.30.3 | 1.30.3 | /Users/pepin/Library/R/3.4/library/GenomicRanges | /Users/pepin/Library/R/3.4/library/GenomicRanges | TRUE | FALSE | 2018-02-26 | Bioconductor | /Users/pepin/Library/R/3.4/library | |
| ggfortify | ggfortify | 0.4.5 | 0.4.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ggfortify | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ggfortify | TRUE | FALSE | 2018-05-26 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| ggplot2 | ggplot2 | 3.1.0 | 3.1.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ggplot2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ggplot2 | TRUE | FALSE | 2018-10-25 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| ggrepel | ggrepel | 0.8.0 | 0.8.0 | /Users/pepin/Library/R/3.4/library/ggrepel | /Users/pepin/Library/R/3.4/library/ggrepel | TRUE | FALSE | 2018-05-09 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| GlobalOptions | GlobalOptions | 0.1.0 | 0.1.0 | /Users/pepin/Library/R/3.4/library/GlobalOptions | /Users/pepin/Library/R/3.4/library/GlobalOptions | FALSE | FALSE | 2018-06-09 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| glue | glue | 1.3.0 | 1.3.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/glue | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/glue | FALSE | FALSE | 2018-07-17 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| graph | graph | 1.56.0 | 1.56.0 | /Users/pepin/Library/R/3.4/library/graph | /Users/pepin/Library/R/3.4/library/graph | TRUE | FALSE | 2017-10-31 | Bioconductor | /Users/pepin/Library/R/3.4/library | |
| gridExtra | gridExtra | 2.3 | 2.3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/gridExtra | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/gridExtra | FALSE | FALSE | 2017-09-09 | CRAN (R 3.4.1) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| gtable | gtable | 0.2.0 | 0.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/gtable | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/gtable | FALSE | FALSE | 2016-02-26 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| gtools | gtools | 3.8.1 | 3.8.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/gtools | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/gtools | TRUE | FALSE | 2018-06-26 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| Haplin | Haplin | 7.0.0 | 7.0.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Haplin | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Haplin | TRUE | FALSE | 2018-05-27 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| highr | highr | 0.7 | 0.7 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/highr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/highr | FALSE | FALSE | 2018-06-09 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| Hmisc | Hmisc | 4.1.1 | 4.1-1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Hmisc | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Hmisc | FALSE | FALSE | 2018-01-03 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| hms | hms | 0.4.2 | 0.4.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/hms | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/hms | FALSE | FALSE | 2018-03-10 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| htmlTable | htmlTable | 1.12 | 1.12 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/htmlTable | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/htmlTable | FALSE | FALSE | 2018-05-26 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| htmltools | htmltools | 0.3.6 | 0.3.6 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/htmltools | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/htmltools | FALSE | FALSE | 2017-04-28 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| htmlwidgets | htmlwidgets | 1.3 | 1.3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/htmlwidgets | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/htmlwidgets | FALSE | FALSE | 2018-09-30 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| httr | httr | 1.3.1 | 1.3.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/httr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/httr | FALSE | FALSE | 2017-08-20 | CRAN (R 3.4.1) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| IRanges | IRanges | 2.12.0 | 2.12.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/IRanges | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/IRanges | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| iterators | iterators | 1.0.10 | 1.0.10 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/iterators | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/iterators | FALSE | FALSE | 2018-07-13 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| jsonlite | jsonlite | 1.5 | 1.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/jsonlite | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/jsonlite | FALSE | FALSE | 2017-06-01 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| kableExtra | kableExtra | 0.9.0 | 0.9.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/kableExtra | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/kableExtra | TRUE | FALSE | 2018-05-21 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| knitr | knitr | 1.20 | 1.20 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/knitr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/knitr | TRUE | FALSE | 2018-02-20 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| labeling | labeling | 0.3 | 0.3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/labeling | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/labeling | FALSE | FALSE | 2014-08-23 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| lattice | lattice | 0.20.35 | 0.20-35 | /Users/pepin/Library/R/3.4/library/lattice | /Users/pepin/Library/R/3.4/library/lattice | TRUE | FALSE | 2017-03-25 | CRAN (R 3.4.0) | /Users/pepin/Library/R/3.4/library | |
| latticeExtra | latticeExtra | 0.6.28 | 0.6-28 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/latticeExtra | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/latticeExtra | FALSE | FALSE | 2016-02-09 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| lazyeval | lazyeval | 0.2.1 | 0.2.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/lazyeval | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/lazyeval | FALSE | FALSE | 2017-10-29 | CRAN (R 3.4.2) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| limma | limma | 3.34.9 | 3.34.9 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/limma | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/limma | TRUE | FALSE | 2018-02-22 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| locfit | locfit | 1.5.9.1 | 1.5-9.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/locfit | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/locfit | FALSE | FALSE | 2013-04-20 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| magrittr | magrittr | 1.5 | 1.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/magrittr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/magrittr | FALSE | FALSE | 2014-11-22 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| MASS | MASS | 7.3.51 | 7.3-51 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/MASS | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/MASS | TRUE | FALSE | 2018-10-16 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| Matrix | Matrix | 1.2.14 | 1.2-14 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Matrix | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/Matrix | FALSE | FALSE | 2018-04-09 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| matrixStats | matrixStats | 0.54.0 | 0.54.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/matrixStats | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/matrixStats | TRUE | FALSE | 2018-07-23 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| memoise | memoise | 1.1.0 | 1.1.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/memoise | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/memoise | FALSE | FALSE | 2017-04-21 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| mgcv | mgcv | 1.8.24 | 1.8-24 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/mgcv | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/mgcv | FALSE | FALSE | 2018-06-18 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| mogene20stprobeset.db | mogene20stprobeset.db | 8.7.0 | 8.7.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/mogene20stprobeset.db | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/mogene20stprobeset.db | TRUE | FALSE | 2018-03-14 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| mogene20sttranscriptcluster.db | mogene20sttranscriptcluster.db | 8.7.0 | 8.7.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/mogene20sttranscriptcluster.db | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/mogene20sttranscriptcluster.db | TRUE | FALSE | 2018-03-14 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| munsell | munsell | 0.5.0 | 0.5.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/munsell | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/munsell | FALSE | FALSE | 2018-06-12 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| nlme | nlme | 3.1.137 | 3.1-137 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/nlme | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/nlme | FALSE | FALSE | 2018-04-07 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| nnet | nnet | 7.3.12 | 7.3-12 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/nnet | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/nnet | FALSE | FALSE | 2016-02-02 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| oligo | oligo | 1.42.0 | 1.42.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/oligo | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/oligo | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| oligoClasses | oligoClasses | 1.40.0 | 1.40.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/oligoClasses | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/oligoClasses | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| openxlsx | openxlsx | 4.1.0 | 4.1.0 | /Users/pepin/Library/R/3.4/library/openxlsx | /Users/pepin/Library/R/3.4/library/openxlsx | TRUE | FALSE | 2018-05-26 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| org.Mm.eg.db | org.Mm.eg.db | 3.5.0 | 3.5.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/org.Mm.eg.db | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/org.Mm.eg.db | TRUE | FALSE | 2018-03-14 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| pd.mogene.2.0.st | pd.mogene.2.0.st | 3.14.1 | 3.14.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pd.mogene.2.0.st | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pd.mogene.2.0.st | TRUE | FALSE | 2018-03-14 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| pheatmap | pheatmap | 1.0.10 | 1.0.10 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pheatmap | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pheatmap | TRUE | FALSE | 2018-05-19 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| pillar | pillar | 1.3.0 | 1.3.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pillar | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pillar | FALSE | FALSE | 2018-07-14 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| pkgbuild | pkgbuild | 1.0.2 | 1.0.2 | /Users/pepin/Library/R/3.4/library/pkgbuild | /Users/pepin/Library/R/3.4/library/pkgbuild | FALSE | FALSE | 2018-10-16 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| pkgconfig | pkgconfig | 2.0.2 | 2.0.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pkgconfig | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/pkgconfig | FALSE | FALSE | 2018-08-16 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| pkgload | pkgload | 1.0.1 | 1.0.1 | /Users/pepin/Library/R/3.4/library/pkgload | /Users/pepin/Library/R/3.4/library/pkgload | FALSE | FALSE | 2018-10-11 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| plotly | plotly | 4.8.0 | 4.8.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/plotly | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/plotly | TRUE | FALSE | 2018-07-20 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| plyr | plyr | 1.8.4 | 1.8.4 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/plyr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/plyr | FALSE | FALSE | 2016-06-08 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| preprocessCore | preprocessCore | 1.40.0 | 1.40.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/preprocessCore | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/preprocessCore | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| prettyunits | prettyunits | 1.0.2 | 1.0.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/prettyunits | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/prettyunits | FALSE | FALSE | 2015-07-13 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| processx | processx | 3.2.0 | 3.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/processx | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/processx | FALSE | FALSE | 2018-08-16 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| progress | progress | 1.2.0 | 1.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/progress | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/progress | FALSE | FALSE | 2018-06-14 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| ps | ps | 1.2.0 | 1.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ps | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/ps | FALSE | FALSE | 2018-10-16 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| purrr | purrr | 0.2.5 | 0.2.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/purrr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/purrr | FALSE | FALSE | 2018-05-29 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| R6 | R6 | 2.3.0 | 2.3.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/R6 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/R6 | FALSE | FALSE | 2018-10-04 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| RBGL | RBGL | 1.54.0 | 1.54.0 | /Users/pepin/Library/R/3.4/library/RBGL | /Users/pepin/Library/R/3.4/library/RBGL | TRUE | FALSE | 2017-10-31 | Bioconductor | /Users/pepin/Library/R/3.4/library | |
| RColorBrewer | RColorBrewer | 1.1.2 | 1.1-2 | /Users/pepin/Library/R/3.4/library/RColorBrewer | /Users/pepin/Library/R/3.4/library/RColorBrewer | TRUE | FALSE | 2014-12-07 | CRAN (R 3.4.0) | /Users/pepin/Library/R/3.4/library | |
| Rcpp | Rcpp | 0.12.19 | 0.12.19 | /Users/pepin/Library/R/3.4/library/Rcpp | /Users/pepin/Library/R/3.4/library/Rcpp | FALSE | FALSE | 2018-10-01 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| RCurl | RCurl | 1.95.4.11 | 1.95-4.11 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/RCurl | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/RCurl | FALSE | FALSE | 2018-07-15 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| readr | readr | 1.1.1 | 1.1.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/readr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/readr | FALSE | FALSE | 2017-05-16 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| remotes | remotes | 2.0.1 | 2.0.1 | /Users/pepin/Library/R/3.4/library/remotes | /Users/pepin/Library/R/3.4/library/remotes | FALSE | FALSE | 2018-10-19 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| reshape | reshape | 0.8.8 | 0.8.8 | /Users/pepin/Library/R/3.4/library/reshape | /Users/pepin/Library/R/3.4/library/reshape | TRUE | FALSE | 2018-10-23 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| rlang | rlang | 0.3.0 | 0.3.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rlang | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rlang | FALSE | FALSE | 2018-10-22 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| rmarkdown | rmarkdown | 1.10 | 1.10 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rmarkdown | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rmarkdown | FALSE | FALSE | 2018-06-11 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| rpart | rpart | 4.1.13 | 4.1-13 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rpart | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rpart | FALSE | FALSE | 2018-02-23 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| rprojroot | rprojroot | 1.3.2 | 1.3-2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rprojroot | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rprojroot | FALSE | FALSE | 2018-01-03 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| RSQLite | RSQLite | 2.1.1 | 2.1.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/RSQLite | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/RSQLite | TRUE | FALSE | 2018-05-06 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| rstudioapi | rstudioapi | 0.8 | 0.8 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rstudioapi | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rstudioapi | FALSE | FALSE | 2018-10-02 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| rvest | rvest | 0.3.2 | 0.3.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rvest | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rvest | FALSE | FALSE | 2016-06-17 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| S4Vectors | S4Vectors | 0.16.0 | 0.16.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/S4Vectors | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/S4Vectors | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| scales | scales | 1.0.0 | 1.0.0 | /Users/pepin/Library/R/3.4/library/scales | /Users/pepin/Library/R/3.4/library/scales | FALSE | FALSE | 2018-08-09 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| sessioninfo | sessioninfo | 1.1.0 | 1.1.0 | /Users/pepin/Library/R/3.4/library/sessioninfo | /Users/pepin/Library/R/3.4/library/sessioninfo | FALSE | FALSE | 2018-09-25 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| shape | shape | 1.4.4 | 1.4.4 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/shape | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/shape | FALSE | FALSE | 2018-02-07 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| snow | snow | 0.4.3 | 0.4-3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/snow | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/snow | FALSE | FALSE | 2018-09-14 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| stringi | stringi | 1.2.4 | 1.2.4 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/stringi | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/stringi | FALSE | FALSE | 2018-07-20 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| stringr | stringr | 1.3.1 | 1.3.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/stringr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/stringr | FALSE | FALSE | 2018-05-10 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| SummarizedExperiment | SummarizedExperiment | 1.8.1 | 1.8.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/SummarizedExperiment | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/SummarizedExperiment | TRUE | FALSE | 2017-12-19 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| SuppDists | SuppDists | 1.1.9.4 | 1.1-9.4 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/SuppDists | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/SuppDists | FALSE | FALSE | 2016-09-23 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| survival | survival | 2.42.6 | 2.42-6 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/survival | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/survival | FALSE | FALSE | 2018-07-13 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| testthat | testthat | 2.0.1 | 2.0.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/testthat | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/testthat | FALSE | FALSE | 2018-10-13 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| tibble | tibble | 1.4.2 | 1.4.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/tibble | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/tibble | FALSE | FALSE | 2018-01-22 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| tidyr | tidyr | 0.8.1 | 0.8.1 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/tidyr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/tidyr | FALSE | FALSE | 2018-05-18 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| tidyselect | tidyselect | 0.2.5 | 0.2.5 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/tidyselect | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/tidyselect | FALSE | FALSE | 2018-10-11 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| usethis | usethis | 1.4.0 | 1.4.0 | /Users/pepin/Library/R/3.4/library/usethis | /Users/pepin/Library/R/3.4/library/usethis | FALSE | FALSE | 2018-08-14 | CRAN (R 3.4.4) | /Users/pepin/Library/R/3.4/library | |
| Vennerable | Vennerable | 3.0 | 3.0 | /Users/pepin/Library/R/3.4/library/Vennerable | /Users/pepin/Library/R/3.4/library/Vennerable | TRUE | FALSE | 2013-07-24 | R-Forge (R 3.4.3) | /Users/pepin/Library/R/3.4/library | |
| viridisLite | viridisLite | 0.3.0 | 0.3.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/viridisLite | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/viridisLite | FALSE | FALSE | 2018-02-01 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| withr | withr | 2.1.2 | 2.1.2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/withr | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/withr | FALSE | FALSE | 2018-03-15 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| XML | XML | 3.98.1.16 | 3.98-1.16 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/XML | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/XML | FALSE | FALSE | 2018-08-19 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| xml2 | xml2 | 1.2.0 | 1.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/xml2 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/xml2 | FALSE | FALSE | 2018-01-24 | CRAN (R 3.4.3) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| xtable | xtable | 1.8.3 | 1.8-3 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/xtable | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/xtable | TRUE | FALSE | 2018-08-29 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| XVector | XVector | 0.18.0 | 0.18.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/XVector | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/XVector | TRUE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| yaml | yaml | 2.2.0 | 2.2.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/yaml | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/yaml | FALSE | FALSE | 2018-07-25 | CRAN (R 3.4.4) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| zip | zip | 1.0.0 | 1.0.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/zip | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/zip | FALSE | FALSE | 2017-04-25 | CRAN (R 3.4.0) | /Library/Frameworks/R.framework/Versions/3.4/Resources/library | |
| zlibbioc | zlibbioc | 1.24.0 | 1.24.0 | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/zlibbioc | /Library/Frameworks/R.framework/Versions/3.4/Resources/library/zlibbioc | FALSE | FALSE | 2017-10-31 | Bioconductor | /Library/Frameworks/R.framework/Versions/3.4/Resources/library |