diff --git a/indication_paths.json b/indication_paths.json
index f566f40b6..2314f0c58 100644
--- a/indication_paths.json
+++ b/indication_paths.json
@@ -510,7 +510,7 @@
       {
         "id": "GO:0006260",
         "label": "BiologicalProcess",
-        "name": "Bactierial DNA Replication"
+        "name": "Bacterial DNA replication"
       },
       {
         "id": "GO:0006412",
@@ -2737,7 +2737,7 @@
       {
         "key": "positively regulates",
         "source": "MESH:D008914",
-        "target": "REACT:R-HSA-568499"
+        "target": "REACT:R-HSA-5684996"
       },
       {
         "key": "produces",
@@ -2755,25 +2755,20 @@
         "target": "MESH:D000505"
       },
       {
-        "key": "positively regulates",
-        "source": "REACT:R-HSA-568499",
+        "key": "contributes to",
+        "source": "REACT:R-HSA-5684996",
         "target": "GO:0043066"
       },
       {
-        "key": "molecularly interacts with",
+        "key": "participates in",
         "source": "UniProt:P48048",
-        "target": "CHEBI:29103"
+        "target": "GO:0060081"
       },
       {
         "key": "located in",
         "source": "GO:0043066",
         "target": "CL:0002559"
       },
-      {
-        "key": "contributes to",
-        "source": "CHEBI:29103",
-        "target": "GO:0060081"
-      },
       {
         "key": "affected by",
         "source": "CL:0002559",
@@ -2782,11 +2777,11 @@
       {
         "key": "negatively regulates",
         "source": "GO:0060081",
-        "target": "GO:0007204"
+        "target": "GO:0070509"
       },
       {
         "key": "negatively correlated with",
-        "source": "GO:0007204",
+        "source": "GO:0070509",
         "target": "GO:0042311"
       },
       {
@@ -2818,7 +2813,7 @@
         "name": "dermal papillary cells"
       },
       {
-        "id": "REACT:R-HSA-568499",
+        "id": "REACT:R-HSA-5684996",
         "label": "Pathway",
         "name": "ERK1/ERK2 pathway"
       },
@@ -2832,11 +2827,6 @@
         "label": "BiologicalProcess",
         "name": "negative regulation of apoptotic process"
       },
-      {
-        "id": "CHEBI:29103",
-        "label": "ChemicalSubstance",
-        "name": "potassium(1+)"
-      },
       {
         "id": "CL:0002559",
         "label": "Cell",
@@ -2848,9 +2838,9 @@
         "name": "membrane hyperpolarization"
       },
       {
-        "id": "GO:0007204",
+        "id": "GO:0070509",
         "label": "BiologicalProcess",
-        "name": "positive regulation of cytosolic calcium ion concentration"
+        "name": "transmembrane calcium influx"
       },
       {
         "id": "GO:0042311",
@@ -2884,31 +2874,21 @@
       "drugbank": "DB:DB00350"
     },
     "links": [
-      {
-        "key": "positively regulates",
-        "source": "MESH:D008914",
-        "target": "UniProt:P48048"
-      },
       {
         "key": "increases activity of",
         "source": "MESH:D008914",
         "target": "UniProt:P48048"
       },
       {
-        "key": "molecularly interacts with",
+        "key": "participates in",
         "source": "UniProt:P48048",
-        "target": "CHEBI:29103"
+        "target": "GO:0060081"
       },
       {
         "key": "participates in",
         "source": "UniProt:P48048",
         "target": "GO:0042311"
       },
-      {
-        "key": "contributes to",
-        "source": "CHEBI:29103",
-        "target": "GO:0060081"
-      },
       {
         "key": "negatively regulates",
         "source": "GO:0042311",
@@ -2917,7 +2897,7 @@
       {
         "key": "negatively regulates",
         "source": "GO:0060081",
-        "target": "GO:0007204"
+        "target": "GO:0070509"
       },
       {
         "key": "positively correlated with",
@@ -2926,7 +2906,7 @@
       },
       {
         "key": "contributes to",
-        "source": "GO:0007204",
+        "source": "GO:0070509",
         "target": "GO:0045907"
       },
       {
@@ -2947,11 +2927,6 @@
         "label": "Protein",
         "name": "ATP-sensitive inward rectifier potassium channel 1"
       },
-      {
-        "id": "CHEBI:29103",
-        "label": "ChemicalSubstance",
-        "name": "potassium(1+)"
-      },
       {
         "id": "GO:0042311",
         "label": "BiologicalProcess",
@@ -2968,9 +2943,9 @@
         "name": "Blood Pressure"
       },
       {
-        "id": "GO:0007204",
+        "id": "GO:0070509",
         "label": "BiologicalProcess",
-        "name": "positive regulation of cytosolic calcium ion concentration"
+        "name": "transmembrane calcium influx"
       },
       {
         "id": "GO:0045907",
@@ -8723,16 +8698,16 @@
       {
         "key": "positively regulates",
         "source": "UniProt:P07550",
-        "target": "GO:0008294"
+        "target": "UniProt:B7Z2C7"
       },
       {
-        "key": "positively regulates",
-        "source": "GO:0008294",
-        "target": "GO:0006171"
+        "key": "increases abundance of",
+        "source": "UniProt:B7Z2C7",
+        "target": "CHEBI:17489"
       },
       {
         "key": "positively correlated with",
-        "source": "GO:0006171",
+        "source": "CHEBI:17489",
         "target": "GO:0044557"
       },
       {
@@ -8759,14 +8734,14 @@
         "name": "Beta-2 adrenergic receptor"
       },
       {
-        "id": "GO:0008294",
-        "label": "BiologicalProcess",
-        "name": "calcium- and calmodulin-responsive adenylate cyclase activity"
+        "id": "UniProt:B7Z2C7",
+        "label": "Protein",
+        "name": "Adenylate cyclase"
       },
       {
-        "id": "GO:0006171",
-        "label": "BiologicalProcess",
-        "name": "cAMP biosynthetic process"
+        "id": "CHEBI:17489",
+        "label": "ChemicalSubstance",
+        "name": "3',5'-cyclic AMP"
       },
       {
         "id": "GO:0044557",
@@ -15469,28 +15444,23 @@
         "target": "UniProt:P48048"
       },
       {
-        "key": "positively regulates",
+        "key": "participates in",
         "source": "UniProt:Q14654",
-        "target": "GO:0051899"
+        "target": "GO:0060081"
       },
       {
-        "key": "positively regulates",
+        "key": "participates in",
         "source": "UniProt:P48048",
-        "target": "GO:0051899"
+        "target": "GO:0060081"
       },
       {
-        "key": "positively regulates",
-        "source": "GO:0051899",
+        "key": "negatively regulates",
+        "source": "GO:0060081",
         "target": "GO:0070509"
       },
       {
-        "key": "located in",
+        "key": "positively regulates",
         "source": "GO:0070509",
-        "target": "CL:0000169"
-      },
-      {
-        "key": "positively correlated with",
-        "source": "CL:0000169",
         "target": "GO:0030073"
       },
       {
@@ -15522,20 +15492,15 @@
         "name": "ATP-sensitive inward rectifier potassium channel 1"
       },
       {
-        "id": "GO:0051899",
+        "id": "GO:0060081",
         "label": "BiologicalProcess",
-        "name": "membrane depolarization"
+        "name": "membrane hyperpolarization"
       },
       {
         "id": "GO:0070509",
         "label": "BiologicalProcess",
         "name": "transmembrane calcium influx"
       },
-      {
-        "id": "CL:0000169",
-        "label": "Cell",
-        "name": "pancreatic beta cell"
-      },
       {
         "id": "GO:0030073",
         "label": "BiologicalProcess",
@@ -18884,6 +18849,128 @@
     ],
     "reference": "https://www.targetvalidation.org/summary?drug=CHEMBL388590 https://en.wikipedia.org/wiki/Uricosuric#Pharmacology https://en.wikipedia.org/wiki/Gout#Cause"
   },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Obesity",
+      "disease_mesh": "MESH:D009765",
+      "drug": "phendimetrazine",
+      "drug_mesh": "MESH:C100294",
+      "drugbank": "DB:DB01579"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:C100294",
+        "target": "UniProt:P35348"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P35348",
+        "target": "GO:0032098"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0032098",
+        "target": "GO:0008152"
+      },
+      {
+        "key": "prevents",
+        "source": "GO:0008152",
+        "target": "MESH:D009765"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C100294",
+        "label": "Drug",
+        "name": "phendimetrazine"
+      },
+      {
+        "id": "UniProt:P35348",
+        "label": "Protein",
+        "name": "Alpha-1A adrenergic receptor"
+      },
+      {
+        "id": "GO:0032098",
+        "label": "BiologicalProcess",
+        "name": "appetite"
+      },
+      {
+        "id": "GO:0008152",
+        "label": "BiologicalProcess",
+        "name": "metabolic process"
+      },
+      {
+        "id": "MESH:D009765",
+        "label": "Disease",
+        "name": "Obesity"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01579#mechanismofaction"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Obesity",
+      "disease_mesh": "MESH:D009765",
+      "drug": "phendimetrazine",
+      "drug_mesh": "MESH:C100294",
+      "drugbank": "DB:DB01579"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:C100294",
+        "target": "UniProt:P35368"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P35368",
+        "target": "GO:0032098"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0032098",
+        "target": "GO:0008152"
+      },
+      {
+        "key": "prevents",
+        "source": "GO:0008152",
+        "target": "MESH:D009765"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C100294",
+        "label": "Drug",
+        "name": "phendimetrazine"
+      },
+      {
+        "id": "UniProt:P35368",
+        "label": "Protein",
+        "name": "Alpha-1B adrenergic receptor"
+      },
+      {
+        "id": "GO:0032098",
+        "label": "BiologicalProcess",
+        "name": "appetite"
+      },
+      {
+        "id": "GO:0008152",
+        "label": "BiologicalProcess",
+        "name": "metabolic process"
+      },
+      {
+        "id": "MESH:D009765",
+        "label": "Disease",
+        "name": "Obesity"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01579#mechanismofaction"
+  },
   {
     "directed": true,
     "graph": {
@@ -18951,8 +19038,8 @@
       "disease": "Obesity",
       "disease_mesh": "MESH:D009765",
       "drug": "phendimetrazine",
-      "drug_mesh": "DB:DB01579",
-      "drugbank": "MESH:C100294"
+      "drug_mesh": "MESH:C100294",
+      "drugbank": "DB:DB01579"
     },
     "links": [
       {
@@ -19022,8 +19109,8 @@
       "disease": "Obesity",
       "disease_mesh": "MESH:D009765",
       "drug": "phendimetrazine",
-      "drug_mesh": "DB:DB01579",
-      "drugbank": "MESH:C100294"
+      "drug_mesh": "MESH:C100294",
+      "drugbank": "DB:DB01579"
     },
     "links": [
       {
@@ -19113,7 +19200,7 @@
         "target": "GO:0061534"
       },
       {
-        "key": "treats",
+        "key": "prevents",
         "source": "GO:0061534",
         "target": "MESH:D004832"
       }
@@ -19194,7 +19281,7 @@
         "target": "GO:0022008"
       },
       {
-        "key": "contributes to",
+        "key": "prevents",
         "source": "GO:0022008",
         "target": "MESH:D004832"
       }
@@ -19239,87 +19326,6 @@
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
   },
-  {
-    "directed": true,
-    "graph": {
-      "disease": "Absence seizure",
-      "disease_mesh": "MESH:D004832",
-      "drug": "valproic acid",
-      "drug_mesh": "MESH:D014635",
-      "drugbank": "DB:DB00313"
-    },
-    "links": [
-      {
-        "key": "molecularly interacts with",
-        "source": "MESH:D014635",
-        "target": "UniProt:P36507"
-      },
-      {
-        "key": "increases activity of",
-        "source": "UniProt:P36507",
-        "target": "UniProt:P28482"
-      },
-      {
-        "key": "increases expression of",
-        "source": "UniProt:P28482",
-        "target": "UniProt:P19419"
-      },
-      {
-        "key": "increases abundance of",
-        "source": "UniProt:P19419",
-        "target": "UniProt:P17677"
-      },
-      {
-        "key": "positively regulates",
-        "source": "UniProt:P17677",
-        "target": "GO:0022008"
-      },
-      {
-        "key": "contributes to",
-        "source": "GO:0022008",
-        "target": "MESH:D004832"
-      }
-    ],
-    "multigraph": true,
-    "nodes": [
-      {
-        "id": "MESH:D014635",
-        "label": "Drug",
-        "name": "valproic acid"
-      },
-      {
-        "id": "UniProt:P36507",
-        "label": "Protein",
-        "name": "mitogen-activated protein kinase (MEK)"
-      },
-      {
-        "id": "UniProt:P28482",
-        "label": "Protein",
-        "name": "Extracellular Signal-Regulated Kinase"
-      },
-      {
-        "id": "UniProt:P19419",
-        "label": "Protein",
-        "name": "ELK-1"
-      },
-      {
-        "id": "UniProt:P17677",
-        "label": "Protein",
-        "name": "growth cone-associated protein-43"
-      },
-      {
-        "id": "GO:0022008",
-        "label": "BiologicalProcess",
-        "name": "neurogenesis"
-      },
-      {
-        "id": "MESH:D004832",
-        "label": "Disease",
-        "name": "Absence seizure"
-      }
-    ],
-    "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
-  },
   {
     "directed": true,
     "graph": {
@@ -19361,7 +19367,7 @@
         "target": "GO:0061534"
       },
       {
-        "key": "treats",
+        "key": "prevents",
         "source": "GO:0061534",
         "target": "MESH:D004832"
       }
@@ -19414,8 +19420,8 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Bipolar disorder",
-      "disease_mesh": "MESH:D001714",
+      "disease": "Absence seizure",
+      "disease_mesh": "MESH:D004832",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
@@ -19424,22 +19430,22 @@
       {
         "key": "decreases activity of",
         "source": "MESH:D014635",
-        "target": "InterPro:IPR002587"
+        "target": "UniProt:Q9UKV0"
       },
       {
-        "key": "decreases activity of",
-        "source": "InterPro:IPR002587",
-        "target": "UniProt:P29218"
+        "key": "positively regulates",
+        "source": "UniProt:Q9UKV0",
+        "target": "GO:0071442"
       },
       {
-        "key": "decreases abundance of",
-        "source": "UniProt:P29218",
-        "target": "MESH:D007294"
+        "key": "increases expression of",
+        "source": "GO:0071442",
+        "target": "UniProt:P23560"
       },
       {
-        "key": "correlated with",
-        "source": "MESH:D007294",
-        "target": "MESH:D001714"
+        "key": "prevents",
+        "source": "UniProt:P23560",
+        "target": "MESH:D004832"
       }
     ],
     "multigraph": true,
@@ -19450,24 +19456,24 @@
         "name": "valproic acid"
       },
       {
-        "id": "InterPro:IPR002587",
-        "label": "GeneFamily",
-        "name": "myo-inositol-1-phophate synthetase"
+        "id": "UniProt:Q9UKV0",
+        "label": "Protein",
+        "name": "histone deactylase (HDAC)"
       },
       {
-        "id": "UniProt:P29218",
-        "label": "Protein",
-        "name": "inositol monophosphatase"
+        "id": "GO:0071442",
+        "label": "BiologicalProcess",
+        "name": "H3 hyperacetylation"
       },
       {
-        "id": "MESH:D007294",
-        "label": "ChemicalSubstance",
-        "name": "inositol"
+        "id": "UniProt:P23560",
+        "label": "Protein",
+        "name": "brain-derived neurotrophic factor (BDNF)"
       },
       {
-        "id": "MESH:D001714",
+        "id": "MESH:D004832",
         "label": "Disease",
-        "name": "Bipolar disorder"
+        "name": "Absence seizure"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19475,37 +19481,42 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Bipolar disorder",
-      "disease_mesh": "MESH:D001714",
+      "disease": "Absence seizure",
+      "disease_mesh": "MESH:D004832",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "negatively regulates",
+        "key": "decreases activity of",
         "source": "MESH:D014635",
-        "target": "UniProt:P29966"
+        "target": "UniProt:P51649"
       },
       {
-        "key": "negatively regulates",
-        "source": "UniProt:P29966",
-        "target": "UniProt:P17252"
+        "key": "increases abundance of",
+        "source": "UniProt:P51649",
+        "target": "MESH:C009338"
       },
       {
-        "key": "located in",
-        "source": "UniProt:P17252",
-        "target": "UBERON:0001870"
+        "key": "decreases activity of",
+        "source": "MESH:C009338",
+        "target": "UniProt:P80404"
       },
       {
-        "key": "contributes to",
-        "source": "UBERON:0001870",
-        "target": "GO:0051823"
+        "key": "disrupts",
+        "source": "UniProt:P80404",
+        "target": "REACT:R-HSA-1430728"
+      },
+      {
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-1430728",
+        "target": "GO:0061534"
       },
       {
         "key": "treats",
-        "source": "GO:0051823",
-        "target": "MESH:D001714"
+        "source": "GO:0061534",
+        "target": "MESH:D004832"
       }
     ],
     "multigraph": true,
@@ -19516,29 +19527,34 @@
         "name": "valproic acid"
       },
       {
-        "id": "UniProt:P29966",
+        "id": "UniProt:P51649",
         "label": "Protein",
-        "name": "Myristoylated alanine-rich C kinase substrate"
+        "name": "succinic semialdehyde dehydrogenase"
       },
       {
-        "id": "UniProt:P17252",
+        "id": "MESH:C009338",
+        "label": "ChemicalSubstance",
+        "name": "succinic semialdehyde"
+      },
+      {
+        "id": "UniProt:P80404",
         "label": "Protein",
-        "name": "Protein kinase C alpha type"
+        "name": "GABA transaminase"
       },
       {
-        "id": "UBERON:0001870",
-        "label": "GrossAnatomicalStructure",
-        "name": "frontal cortex"
+        "id": "REACT:R-HSA-1430728",
+        "label": "Pathway",
+        "name": "GABA metabolism"
       },
       {
-        "id": "GO:0051823",
+        "id": "GO:0061534",
         "label": "BiologicalProcess",
-        "name": "synaptic remodeling"
+        "name": "GABAergic neurotransmission"
       },
       {
-        "id": "MESH:D001714",
+        "id": "MESH:D004832",
         "label": "Disease",
-        "name": "Bipolar disorder"
+        "name": "Absence seizure"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19546,37 +19562,42 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Bipolar disorder",
-      "disease_mesh": "MESH:D001714",
+      "disease": "Absence seizure",
+      "disease_mesh": "MESH:D004832",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "negatively regulates",
+        "key": "molecularly interacts with",
         "source": "MESH:D014635",
-        "target": "UniProt:P29966"
+        "target": "UniProt:P36507"
       },
       {
-        "key": "negatively regulates",
-        "source": "UniProt:P29966",
-        "target": "UniProt:Q02156"
+        "key": "increases activity of",
+        "source": "UniProt:P36507",
+        "target": "UniProt:P28482"
       },
       {
-        "key": "located in",
-        "source": "UniProt:Q02156",
-        "target": "UBERON:0001870"
+        "key": "increases expression of",
+        "source": "UniProt:P28482",
+        "target": "UniProt:P19419"
       },
       {
-        "key": "contributes to",
-        "source": "UBERON:0001870",
-        "target": "GO:0051823"
+        "key": "increases abundance of",
+        "source": "UniProt:P19419",
+        "target": "UniProt:P01100"
       },
       {
-        "key": "treats",
-        "source": "GO:0051823",
-        "target": "MESH:D001714"
+        "key": "positively regulates",
+        "source": "UniProt:P01100",
+        "target": "GO:0022008"
+      },
+      {
+        "key": "contributes to",
+        "source": "GO:0022008",
+        "target": "MESH:D004832"
       }
     ],
     "multigraph": true,
@@ -19587,29 +19608,34 @@
         "name": "valproic acid"
       },
       {
-        "id": "UniProt:P29966",
+        "id": "UniProt:P36507",
         "label": "Protein",
-        "name": "Myristoylated alanine-rich C kinase substrate"
+        "name": "mitogen-activated protein kinase (MEK)"
       },
       {
-        "id": "UniProt:Q02156",
+        "id": "UniProt:P28482",
         "label": "Protein",
-        "name": "protein kinase C (PKC)-\u03b5"
+        "name": "Extracellular Signal-Regulated Kinase"
       },
       {
-        "id": "UBERON:0001870",
-        "label": "GrossAnatomicalStructure",
-        "name": "frontal cortex"
+        "id": "UniProt:P19419",
+        "label": "Protein",
+        "name": "ELK-1"
       },
       {
-        "id": "GO:0051823",
+        "id": "UniProt:P01100",
+        "label": "Protein",
+        "name": "c-fos"
+      },
+      {
+        "id": "GO:0022008",
         "label": "BiologicalProcess",
-        "name": "synaptic remodeling"
+        "name": "neurogenesis"
       },
       {
-        "id": "MESH:D001714",
+        "id": "MESH:D004832",
         "label": "Disease",
-        "name": "Bipolar disorder"
+        "name": "Absence seizure"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19617,32 +19643,42 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Epilepsy",
-      "disease_mesh": "MESH:D004827",
+      "disease": "Absence seizure",
+      "disease_mesh": "MESH:D004832",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "negatively regulates",
+        "key": "molecularly interacts with",
         "source": "MESH:D014635",
-        "target": "REACT:R-HSA-211976"
+        "target": "UniProt:P36507"
       },
       {
-        "key": "disrupts",
-        "source": "REACT:R-HSA-211976",
-        "target": "MESH:D008560"
+        "key": "increases activity of",
+        "source": "UniProt:P36507",
+        "target": "UniProt:P28482"
+      },
+      {
+        "key": "increases expression of",
+        "source": "UniProt:P28482",
+        "target": "UniProt:P19419"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "UniProt:P19419",
+        "target": "UniProt:P17677"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D008560",
-        "target": "GO:0099611"
+        "source": "UniProt:P17677",
+        "target": "GO:0022008"
       },
       {
-        "key": "correlated with",
-        "source": "GO:0099611",
-        "target": "MESH:D004827"
+        "key": "contributes to",
+        "source": "GO:0022008",
+        "target": "MESH:D004832"
       }
     ],
     "multigraph": true,
@@ -19653,27 +19689,34 @@
         "name": "valproic acid"
       },
       {
-        "alt_ids": [
-          "KEGG:M00100"
-        ],
-        "id": "REACT:R-HSA-211976",
-        "label": "Pathway",
-        "name": "sterol metabolism"
+        "id": "UniProt:P36507",
+        "label": "Protein",
+        "name": "mitogen-activated protein kinase (MEK)"
       },
       {
-        "id": "MESH:D008560",
-        "label": "BiologicalProcess",
-        "name": "membrane fluidity"
+        "id": "UniProt:P28482",
+        "label": "Protein",
+        "name": "Extracellular Signal-Regulated Kinase"
       },
       {
-        "id": "GO:0099611",
+        "id": "UniProt:P19419",
+        "label": "Protein",
+        "name": "ELK-1"
+      },
+      {
+        "id": "UniProt:P17677",
+        "label": "Protein",
+        "name": "growth cone-associated protein-43"
+      },
+      {
+        "id": "GO:0022008",
         "label": "BiologicalProcess",
-        "name": "action potential threshold"
+        "name": "neurogenesis"
       },
       {
-        "id": "MESH:D004827",
+        "id": "MESH:D004832",
         "label": "Disease",
-        "name": "Epilepsy"
+        "name": "Absence seizure"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19681,32 +19724,47 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Epilepsy",
-      "disease_mesh": "MESH:D004827",
+      "disease": "Absence seizure",
+      "disease_mesh": "MESH:D004832",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "negatively regulates",
+        "key": "molecularly interacts with",
         "source": "MESH:D014635",
-        "target": "REACT:R-HSA-556833"
+        "target": "UniProt:P36507"
       },
       {
-        "key": "disrupts",
-        "source": "REACT:R-HSA-556833",
-        "target": "MESH:D008560"
+        "key": "increases activity of",
+        "source": "UniProt:P36507",
+        "target": "UniProt:P28482"
+      },
+      {
+        "key": "increases expression of",
+        "source": "UniProt:P28482",
+        "target": "UniProt:P19419"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "UniProt:P19419",
+        "target": "UniProt:P23560"
+      },
+      {
+        "key": "increases activity of",
+        "source": "UniProt:P23560",
+        "target": "UniProt:P14867"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D008560",
-        "target": "GO:0099611"
+        "source": "UniProt:P14867",
+        "target": "GO:0061534"
       },
       {
-        "key": "correlated with",
-        "source": "GO:0099611",
-        "target": "MESH:D004827"
+        "key": "treats",
+        "source": "GO:0061534",
+        "target": "MESH:D004832"
       }
     ],
     "multigraph": true,
@@ -19717,27 +19775,39 @@
         "name": "valproic acid"
       },
       {
-        "alt_ids": [
-          "KEGG:M00561"
-        ],
-        "id": "REACT:R-HSA-556833",
-        "label": "Pathway",
-        "name": "glycerolipids metabolism"
+        "id": "UniProt:P36507",
+        "label": "Protein",
+        "name": "mitogen-activated protein kinase (MEK)"
       },
       {
-        "id": "MESH:D008560",
-        "label": "BiologicalProcess",
-        "name": "membrane fluidity"
+        "id": "UniProt:P28482",
+        "label": "Protein",
+        "name": "Extracellular Signal-Regulated Kinase"
       },
       {
-        "id": "GO:0099611",
+        "id": "UniProt:P19419",
+        "label": "Protein",
+        "name": "ELK-1"
+      },
+      {
+        "id": "UniProt:P23560",
+        "label": "Protein",
+        "name": "brain-derived neurotrophic factor (BDNF)"
+      },
+      {
+        "id": "UniProt:P14867",
+        "label": "Protein",
+        "name": "GABAA receptors"
+      },
+      {
+        "id": "GO:0061534",
         "label": "BiologicalProcess",
-        "name": "action potential threshold"
+        "name": "GABAergic neurotransmission"
       },
       {
-        "id": "MESH:D004827",
+        "id": "MESH:D004832",
         "label": "Disease",
-        "name": "Epilepsy"
+        "name": "Absence seizure"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19745,8 +19815,8 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Epilepsy",
-      "disease_mesh": "MESH:D004827",
+      "disease": "Absence seizure",
+      "disease_mesh": "MESH:D004832",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
@@ -19763,19 +19833,14 @@
         "target": "GO:0045893"
       },
       {
-        "key": "decreases activity of",
+        "key": "increases expression of",
         "source": "GO:0045893",
-        "target": "UniProt:P04406"
-      },
-      {
-        "key": "prevents",
-        "source": "UniProt:P04406",
-        "target": "MESH:D009410"
+        "target": "UniProt:P23560"
       },
       {
-        "key": "correlated with",
-        "source": "MESH:D009410",
-        "target": "MESH:D004827"
+        "key": "treats",
+        "source": "UniProt:P23560",
+        "target": "MESH:D004832"
       }
     ],
     "multigraph": true,
@@ -19796,19 +19861,14 @@
         "name": "gene transcription"
       },
       {
-        "id": "UniProt:P04406",
+        "id": "UniProt:P23560",
         "label": "Protein",
-        "name": "glyceraldehyde-3-phosphate dehydrogenase"
-      },
-      {
-        "id": "MESH:D009410",
-        "label": "BiologicalProcess",
-        "name": "neural degeneration"
+        "name": "brain-derived neurotrophic factor (BDNF)"
       },
       {
-        "id": "MESH:D004827",
+        "id": "MESH:D004832",
         "label": "Disease",
-        "name": "Epilepsy"
+        "name": "Absence seizure"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19816,8 +19876,8 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Absence seizure",
-      "disease_mesh": "MESH:D004832",
+      "disease": "Bipolar disorder",
+      "disease_mesh": "MESH:D001714",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
@@ -19826,22 +19886,22 @@
       {
         "key": "decreases activity of",
         "source": "MESH:D014635",
-        "target": "UniProt:Q9UKV0"
+        "target": "InterPro:IPR002587"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:Q9UKV0",
-        "target": "GO:0045893"
+        "key": "decreases activity of",
+        "source": "InterPro:IPR002587",
+        "target": "UniProt:P29218"
       },
       {
-        "key": "increases expression of",
-        "source": "GO:0045893",
-        "target": "UniProt:P23560"
+        "key": "decreases abundance of",
+        "source": "UniProt:P29218",
+        "target": "MESH:D007294"
       },
       {
-        "key": "treats",
-        "source": "UniProt:P23560",
-        "target": "MESH:D004832"
+        "key": "correlated with",
+        "source": "MESH:D007294",
+        "target": "MESH:D001714"
       }
     ],
     "multigraph": true,
@@ -19852,24 +19912,24 @@
         "name": "valproic acid"
       },
       {
-        "id": "UniProt:Q9UKV0",
-        "label": "Protein",
-        "name": "histone deactylase (HDAC)"
+        "id": "InterPro:IPR002587",
+        "label": "GeneFamily",
+        "name": "myo-inositol-1-phophate synthetase"
       },
       {
-        "id": "GO:0045893",
-        "label": "BiologicalProcess",
-        "name": "gene transcription"
+        "id": "UniProt:P29218",
+        "label": "Protein",
+        "name": "inositol monophosphatase"
       },
       {
-        "id": "UniProt:P23560",
-        "label": "Protein",
-        "name": "brain-derived neurotrophic factor (BDNF)"
+        "id": "MESH:D007294",
+        "label": "ChemicalSubstance",
+        "name": "inositol"
       },
       {
-        "id": "MESH:D004832",
+        "id": "MESH:D001714",
         "label": "Disease",
-        "name": "Absence seizure"
+        "name": "Bipolar disorder"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19877,37 +19937,37 @@
   {
     "directed": true,
     "graph": {
-      "disease": "migraine",
-      "disease_mesh": "MESH:D008881",
+      "disease": "Bipolar disorder",
+      "disease_mesh": "MESH:D001714",
       "drug": "valproic acid",
       "drug_mesh": "MESH:D014635",
       "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "decreases activity of",
+        "key": "negatively regulates",
         "source": "MESH:D014635",
-        "target": "UniProt:O14975"
+        "target": "UniProt:P29966"
       },
       {
-        "key": "located in",
-        "source": "UniProt:O14975",
-        "target": "UBERON:0000955"
+        "key": "negatively regulates",
+        "source": "UniProt:P29966",
+        "target": "UniProt:P17252"
       },
       {
-        "key": "decreases abundance of",
-        "source": "UBERON:0000955",
-        "target": "MESH:C026563"
+        "key": "located in",
+        "source": "UniProt:P17252",
+        "target": "UBERON:0001870"
       },
       {
-        "key": "participates in",
-        "source": "MESH:C026563",
-        "target": "REACT:R-HSA-2162123"
+        "key": "contributes to",
+        "source": "UBERON:0001870",
+        "target": "GO:0051823"
       },
       {
         "key": "treats",
-        "source": "REACT:R-HSA-2162123",
-        "target": "MESH:D008881"
+        "source": "GO:0051823",
+        "target": "MESH:D001714"
       }
     ],
     "multigraph": true,
@@ -19918,29 +19978,29 @@
         "name": "valproic acid"
       },
       {
-        "id": "UniProt:O14975",
+        "id": "UniProt:P29966",
         "label": "Protein",
-        "name": "microsomal long-chain fatty acyl-CoA synthetase"
+        "name": "Myristoylated alanine-rich C kinase substrate"
       },
       {
-        "id": "UBERON:0000955",
-        "label": "GrossAnatomicalStructure",
-        "name": "brain"
+        "id": "UniProt:P17252",
+        "label": "Protein",
+        "name": "Protein kinase C alpha type"
       },
       {
-        "id": "MESH:C026563",
-        "label": "ChemicalSubstance",
-        "name": "Arachidonoyl-CoA"
+        "id": "UBERON:0001870",
+        "label": "GrossAnatomicalStructure",
+        "name": "frontal cortex"
       },
       {
-        "id": "REACT:R-HSA-2162123",
-        "label": "Pathway",
-        "name": "inflammatory prostaglandins production"
+        "id": "GO:0051823",
+        "label": "BiologicalProcess",
+        "name": "synaptic remodeling"
       },
       {
-        "id": "MESH:D008881",
+        "id": "MESH:D001714",
         "label": "Disease",
-        "name": "migraine"
+        "name": "Bipolar disorder"
       }
     ],
     "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
@@ -19948,9366 +20008,33687 @@
   {
     "directed": true,
     "graph": {
-      "disease": "Human immunodeficiency virus infection",
-      "disease_mesh": "MESH:D015658",
-      "drug": "zidovudine",
-      "drug_mesh": "MESH:D015215",
-      "drugbank": "DB:DB00495"
+      "disease": "Bipolar disorder",
+      "disease_mesh": "MESH:D001714",
+      "drug": "valproic acid",
+      "drug_mesh": "MESH:D014635",
+      "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "increases abundance of",
-        "source": "MESH:D015215",
-        "target": "MESH:C052873"
+        "key": "negatively regulates",
+        "source": "MESH:D014635",
+        "target": "UniProt:P29966"
       },
       {
-        "key": "decreases activity of",
-        "source": "MESH:C052873",
-        "target": "UniProt:Q72547"
+        "key": "negatively regulates",
+        "source": "UniProt:P29966",
+        "target": "UniProt:Q02156"
       },
       {
-        "key": "in taxon",
-        "source": "UniProt:Q72547",
-        "target": "NCBITaxon:11676"
+        "key": "located in",
+        "source": "UniProt:Q02156",
+        "target": "UBERON:0001870"
       },
       {
-        "key": "expressed in",
-        "source": "NCBITaxon:11676",
-        "target": "GO:0039693"
+        "key": "contributes to",
+        "source": "UBERON:0001870",
+        "target": "GO:0051823"
       },
       {
-        "key": "causes",
-        "source": "GO:0039693",
-        "target": "MESH:D015658"
+        "key": "treats",
+        "source": "GO:0051823",
+        "target": "MESH:D001714"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "MESH:D015215",
+        "id": "MESH:D014635",
         "label": "Drug",
-        "name": "zidovudine"
+        "name": "valproic acid"
       },
       {
-        "id": "MESH:C052873",
-        "label": "ChemicalSubstance",
-        "name": "zidovudine triphosphate"
+        "id": "UniProt:P29966",
+        "label": "Protein",
+        "name": "Myristoylated alanine-rich C kinase substrate"
       },
       {
-        "id": "UniProt:Q72547",
+        "id": "UniProt:Q02156",
         "label": "Protein",
-        "name": "HIV-1 reverse transcriptase (RT)"
+        "name": "protein kinase C (PKC)-\u03b5"
       },
       {
-        "id": "NCBITaxon:11676",
-        "label": "OrganismTaxon",
-        "name": "HIV-1"
+        "id": "UBERON:0001870",
+        "label": "GrossAnatomicalStructure",
+        "name": "frontal cortex"
       },
       {
-        "id": "GO:0039693",
+        "id": "GO:0051823",
         "label": "BiologicalProcess",
-        "name": "Viral DNA replication"
+        "name": "synaptic remodeling"
       },
       {
-        "id": "MESH:D015658",
+        "id": "MESH:D001714",
         "label": "Disease",
-        "name": "Human immunodeficiency virus infection"
+        "name": "Bipolar disorder"
       }
     ],
-    "reference": "https://go.drugbank.com/drugs/DB00495#mechanismofaction"
+    "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
   },
   {
     "directed": true,
     "graph": {
-      "disease": "Opioid dependence",
-      "disease_mesh": "MESH:D009293",
-      "drug": "levomethadyl acetate",
-      "drug_mesh": null,
-      "drugbank": "DB:DB01227"
+      "disease": "Epilepsy",
+      "disease_mesh": "MESH:D004827",
+      "drug": "valproic acid",
+      "drug_mesh": "MESH:D014635",
+      "drugbank": "DB:DB00313"
     },
     "links": [
       {
-        "key": "increases activity of",
-        "source": "DB:DB01227",
-        "target": "UniProt:P35372"
+        "key": "decreases activity of",
+        "source": "MESH:D014635",
+        "target": "UniProt:Q9UKV0"
       },
       {
-        "key": "produces",
-        "source": "UniProt:P35372",
-        "target": "GO:0060081"
+        "key": "positively regulates",
+        "source": "UniProt:Q9UKV0",
+        "target": "GO:0071442"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "GO:0071442",
+        "target": "UniProt:P04406"
       },
       {
         "key": "prevents",
-        "source": "GO:0060081",
-        "target": "GO:0019228"
+        "source": "UniProt:P04406",
+        "target": "MESH:D009410"
       },
       {
-        "key": "causes",
-        "source": "GO:0019228",
-        "target": "MESH:D009293"
+        "key": "correlated with",
+        "source": "MESH:D009410",
+        "target": "MESH:D004827"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB01227",
+        "id": "MESH:D014635",
         "label": "Drug",
-        "name": "Levomethadyl acetate"
+        "name": "valproic acid"
       },
       {
-        "id": "UniProt:P35372",
+        "id": "UniProt:Q9UKV0",
         "label": "Protein",
-        "name": "Mu opioid receptor"
+        "name": "histone deactylase (HDAC)"
       },
       {
-        "id": "GO:0060081",
+        "id": "GO:0071442",
         "label": "BiologicalProcess",
-        "name": "hyperpolarization"
+        "name": "H3 hyperacetylation"
       },
       {
-        "id": "GO:0019228",
+        "id": "UniProt:P04406",
+        "label": "Protein",
+        "name": "glyceraldehyde-3-phosphate dehydrogenase"
+      },
+      {
+        "id": "MESH:D009410",
         "label": "BiologicalProcess",
-        "name": "neuronal excitability"
+        "name": "neural degeneration"
       },
       {
-        "id": "MESH:D009293",
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-        "id": "GO:0070527",
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-        "name": "platelet aggregation"
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       },
       {
-        "id": "MESH:D054058",
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         "label": "Disease",
-        "name": "Acute coronary syndrome"
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       }
     ],
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     "directed": true,
     "graph": {
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-      "drug": "clopidogrel",
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       "drug_mesh": null,
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     "directed": true,
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-        "target": "UniProt:P35367"
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       },
       {
         "key": "treats",
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-        "target": "MESH:D006255"
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       }
     ],
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         "label": "Drug",
-        "name": "brompheniramine"
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+        "name": "ATP-sensitive inward rectifier potassium channel 11"
+      },
+      {
+        "id": "GO:0060081",
+        "label": "BiologicalProcess",
+        "name": "membrane hyperpolarization"
+      },
+      {
+        "id": "GO:0070509",
+        "label": "BiologicalProcess",
+        "name": "transmembrane calcium influx"
+      },
+      {
+        "id": "GO:0030073",
+        "label": "BiologicalProcess",
+        "name": "insulin secretion"
+      },
+      {
+        "id": "MESH:D006946",
+        "label": "Disease",
+        "name": "Hyperinsulinism"
+      },
+      {
+        "id": "MESH:D046768",
+        "label": "Disease",
+        "name": "Islet cell hyperplasia"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01119#BE0000708 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020366/"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Disorder of biliary tract",
+      "disease_mesh": "MESH:D001660",
+      "drug": "cholic acid",
+      "drug_mesh": "MESH:D019826",
+      "drugbank": "DB:DB02659"
+    },
+    "links": [
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+        "key": "produced by",
+        "source": "MESH:D019826",
+        "target": "UBERON:0002423"
+      },
+      {
+        "key": "affected by",
+        "source": "UBERON:0002423",
+        "target": "MESH:D001660"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
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+        "id": "MESH:D019826",
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+        "name": "cholic acid"
+      },
+      {
+        "id": "UBERON:0002423",
+        "label": "GrossAnatomicalStructure",
+        "name": "hepatobiliary system"
+      },
+      {
+        "id": "MESH:D001660",
+        "label": "Disease",
+        "name": "Disorder of biliary tract"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB02659"
+  },
+  {
+    "comment": "Cholic acid is not a common treatment for Cholelithiasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348960/",
+    "directed": true,
+    "graph": {
+      "disease": "Cholelithiasis",
+      "disease_mesh": "MESH:D002769",
+      "drug": "cholic acid",
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+    },
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+        "target": "MESH:D002769"
+      }
+    ],
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+        "name": "cholic acid"
+      },
+      {
+        "id": "MESH:D002769",
+        "label": "Disease",
+        "name": "Cholelithiasis"
+      }
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D003248",
+      "drug": "cholic acid",
+      "drug_mesh": "MESH:D019826",
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+    },
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+        "key": "positively regulates",
+        "source": "MESH:D019826",
+        "target": "GO:0030432"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0030432",
+        "target": "MESH:D003248"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
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+        "name": "cholic acid"
+      },
+      {
+        "id": "GO:0030432",
+        "label": "BiologicalProcess",
+        "name": "peristalsis"
+      },
+      {
+        "id": "MESH:D003248",
+        "label": "Disease",
+        "name": "Constipation"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB02659 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015201/"
+  },
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+    "graph": {
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+    },
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+      },
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+      },
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+      },
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+        "target": "MESH:D019294"
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+    ],
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+        "name": "sterol 27-hydroxylase activity"
+      },
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+        "id": "MESH:D019294",
+        "label": "Disease",
+        "name": "Cerebrotendinous Xanthomatosis"
+      },
+      {
+        "id": "MESH:D004083",
+        "label": "ChemicalSubstance",
+        "name": "Cholestanol"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB02659 https://www.ncbi.nlm.nih.gov/books/NBK395578/"
+  },
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+      "drugbank": "DB:DB08976"
+    },
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+        "target": "UniProt:P23219"
+      },
+      {
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+        "source": "DB:DB08976",
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+      },
+      {
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+      },
+      {
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+      },
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+      },
+      {
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+        "target": "MESH:D059787"
+      }
+    ],
+    "multigraph": true,
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+        "name": "floctafenine"
+      },
+      {
+        "id": "UniProt:P23219",
+        "label": "Protein",
+        "name": "Prostaglandin G/H synthase 1"
+      },
+      {
+        "id": "UniProt:P35354",
+        "label": "Protein",
+        "name": "Prostaglandin G/H synthase 2"
+      },
+      {
+        "id": "MESH:D011453",
+        "label": "ChemicalSubstance",
+        "name": "Prostaglandins"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "MESH:D059787",
+        "label": "Disease",
+        "name": "Acute pain"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB08976  https://drugs.ncats.io/substances?q=%22FLOCTAFENINE%22&facet=Substance%20Form%2FPrincipal%20Form"
+  },
+  {
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D029424",
+      "drug": "umeclidinium",
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+      "drugbank": "DB:DB09076"
+    },
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+        "key": "decreases activity of",
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+        "target": "UniProt:P08172"
+      },
+      {
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+        "target": "UniProt:P20309"
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+      },
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+        "target": "UBERON:0002185"
+      },
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+      },
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+        "source": "GO:0006954",
+        "target": "MESH:D029424"
+      }
+    ],
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+        "name": "umeclidinium"
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+        "label": "Protein",
+        "name": "Muscarinic acetylcholine receptor M2"
+      },
+      {
+        "id": "UniProt:P20309",
+        "label": "Protein",
+        "name": "Muscarinic acetylcholine receptor M3"
+      },
+      {
+        "id": "GO:1905144",
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+        "name": "response to acetylcholine"
+      },
+      {
+        "id": "GO:0006939",
+        "label": "BiologicalProcess",
+        "name": "smooth muscle contraction"
+      },
+      {
+        "id": "UBERON:0002185",
+        "label": "GrossAnatomicalStructure",
+        "name": "bronchus"
+      },
+      {
+        "id": "GO:0006954",
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+        "name": "inflammatory response"
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+      {
+        "id": "MESH:D029424",
+        "label": "Disease",
+        "name": "Chronic obstructive lung disease"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB09076#BE0000560   https://en.wikipedia.org/wiki/Chronic_obstructive_pulmonary_disease"
+  },
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+        "target": "MESH:D012223"
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+        "name": "response to histamine"
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+      {
+        "id": "MESH:D013373",
+        "label": "ChemicalSubstance",
+        "name": "Substance P"
+      },
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+        "id": "MESH:D020078",
+        "label": "Disease",
+        "name": "Neurogenic Inflammation"
+      },
+      {
+        "id": "MESH:D012223",
+        "label": "Disease",
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+      }
+    ],
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+  },
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+        "name": "neuronal signal transduction"
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+        "name": "Sneezing"
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+  },
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+        "target": "NCBITaxon:10239"
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+        "source": "NCBITaxon:10239",
+        "target": "MESH:D003139"
+      }
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+        "name": "response to histamine"
+      },
+      {
+        "id": "REACT:R-HSA-388396",
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+        "name": "GPCR downstream signalling"
+      },
+      {
+        "id": "UniProt:P19838",
+        "label": "Protein",
+        "name": "Nuclear factor NF-kappa-B p105 subunit"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "NCBITaxon:10239",
+        "label": "OrganismTaxon",
+        "name": "Viruses"
+      },
+      {
+        "id": "MESH:D003139",
+        "label": "Disease",
+        "name": "Common cold"
+      }
+    ],
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+  },
+  {
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+    "graph": {
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+      "disease_mesh": "MESH:D065631",
+      "drug": "acrivastine",
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+      "drugbank": "DB:DB09488"
+    },
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+        "target": "UniProt:P35367"
+      },
+      {
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+      },
+      {
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+      },
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+        "key": "increases activity of",
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+      },
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+      },
+      {
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+      },
+      {
+        "key": "affected by",
+        "source": "UBERON:0010061",
+        "target": "MESH:D065631"
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+    ],
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+        "name": "Histamine H1 receptor"
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+        "id": "REACT:R-HSA-388396",
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+        "name": "inflammatory response"
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+      {
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+        "name": "nasopharynx cavity"
+      },
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+        "name": "Allergic rhinitis"
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+    ],
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+    },
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+      },
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+        "target": "GO:0030641"
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+      },
+      {
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+        "source": "NCBITaxon:5476",
+        "target": "MESH:D010032"
+      }
+    ],
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+      },
+      {
+        "id": "GO:0030641",
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+        "name": "regulation of cellular pH"
+      },
+      {
+        "id": "NCBITaxon:5476",
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+        "name": "Candida albicans"
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+      {
+        "id": "MESH:D010032",
+        "label": "Disease",
+        "name": "Otitis externa"
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+    ],
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+    },
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+      },
+      {
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+      },
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+      }
+    ],
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+        "name": "type 2 immune response"
+      },
+      {
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+        "label": "Disease",
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+    ],
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+  },
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+      },
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+        "target": "MESH:D017497"
+      }
+    ],
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+        "label": "Protein",
+        "name": "Tumor necrosis factor"
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+      {
+        "id": "REACT:R-HSA-75893",
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+        "name": "TNF signaling"
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+        "name": "inflammation"
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+      {
+        "id": "MESH:D017497",
+        "label": "Disease",
+        "name": "Hidradenitis suppurativa"
+      }
+    ],
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+        "name": "inflammation"
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+        "label": "Disease",
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+        "target": "MESH:D001171"
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+        "name": "inflammation"
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+        "label": "Disease",
+        "name": "Psoriasis with arthropathy"
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+  },
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+        "target": "MESH:D013167"
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+        "label": "Disease",
+        "name": "Ankylosing spondylitis"
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+        "name": "Oxytocin receptor"
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+      {
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+        "name": "uterine smooth muscle contraction"
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+        "label": "Disease",
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+        "name": "metalloenzyme inhibitor activity"
+      },
+      {
+        "id": "MESH:D012628",
+        "label": "Disease",
+        "name": "Seborrheic dermatitis"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01188 https://en.wikipedia.org/wiki/Seborrhoeic_dermatitis"
+  },
+  {
+    "comment": "Mibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs",
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D006973",
+      "drug": "mibefradil",
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+        "name": "Blood Pressure"
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+        "name": "blood circulation"
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+        "name": "Angina pectoris"
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+    "comment": "Mechanism of action of diloxanide is unknown",
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+    },
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+        "label": "Protein",
+        "name": "Vascular endothelial growth factor receptor 1"
+      },
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+        "label": "Protein",
+        "name": "Vascular endothelial growth factor receptor 2"
+      },
+      {
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+        "name": "Signaling by Receptor Tyrosine Kinases"
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+        "name": "vasodilation"
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+        "label": "Disease",
+        "name": "Pulmonary arterial hypertension"
+      }
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+  },
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+      "disease_mesh": "MESH:D017192",
+      "drug": "delafloxacin",
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+      "drugbank": "DB:DB11943"
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+        "target": "UniProt:P0C1U9"
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+        "target": "NCBITaxon:1280"
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+        "target": "MESH:D017192"
+      }
+    ],
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+      {
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+        "label": "Protein",
+        "name": "DNA topoisomerase 4 subunit A (Staphylococcus aureus)"
+      },
+      {
+        "id": "UniProt:Q2FKQ0",
+        "label": "Protein",
+        "name": "DNA gyrase subunit A (Staphylococcus aureus)"
+      },
+      {
+        "id": "GO:0044787",
+        "label": "BiologicalProcess",
+        "name": "bacterial-type DNA replication"
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+      {
+        "id": "NCBITaxon:1280",
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+        "name": "Staphylococcus aureus"
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+      {
+        "id": "MESH:D017192",
+        "label": "Disease",
+        "name": "Bacterial Skin Diseases"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB11943 https://en.wikipedia.org/wiki/Cellulitis"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Allergic rhinitis",
+      "disease_mesh": "MESH:D065631",
+      "drug": "mizolastine",
+      "drug_mesh": "MESH:C076170",
+      "drugbank": "DB:DB12523"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C076170",
+        "target": "UniProt:P35367"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P35367",
+        "target": "GO:0004969"
+      },
+      {
+        "key": "participates in",
+        "source": "GO:0004969",
+        "target": "GO:0071420"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0071420",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D065631"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C076170",
+        "label": "Drug",
+        "name": "mizolastine"
+      },
+      {
+        "id": "UniProt:P35367",
+        "label": "Protein",
+        "name": "Histamine H1 receptor"
+      },
+      {
+        "id": "GO:0004969",
+        "label": "MolecularActivity",
+        "name": "histamine receptor activity"
+      },
+      {
+        "id": "GO:0071420",
+        "label": "BiologicalProcess",
+        "name": "cellular response to histamine"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "MESH:D065631",
+        "label": "Disease",
+        "name": "Allergic rhinitis"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Mizolastine https://en.wikipedia.org/wiki/Antihistamine#H1-antihistamines"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Peptic ulcer",
+      "disease_mesh": "MESH:D010437",
+      "drug": "carbenoxolone",
+      "drug_mesh": "MESH:D002229",
+      "drugbank": "DB:DB02329"
+    },
+    "links": [
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+        "key": "negatively regulates",
+        "source": "MESH:D002229",
+        "target": "UniProt:P28845"
+      },
+      {
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+        "source": "MESH:D002229",
+        "target": "UniProt:P15428"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P28845",
+        "target": "GO:0016491"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P15428",
+        "target": "GO:0016616"
+      },
+      {
+        "key": "decreases abundance of",
+        "source": "GO:0016491",
+        "target": "MESH:D011453"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0016616",
+        "target": "MESH:D011453"
+      },
+      {
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+        "source": "MESH:D011453",
+        "target": "GO:0070254"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D011453",
+        "target": "GO:0008283"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "MESH:D011453",
+        "target": "GO:0001696"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0070254",
+        "target": "MESH:D010437"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0008283",
+        "target": "MESH:D010437"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0001696",
+        "target": "MESH:D010437"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002229",
+        "label": "Drug",
+        "name": "carbenoxolone"
+      },
+      {
+        "id": "UniProt:P28845",
+        "label": "Protein",
+        "name": "Corticosteroid 11-beta-dehydrogenase isozyme 1"
+      },
+      {
+        "id": "UniProt:P15428",
+        "label": "Protein",
+        "name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]"
+      },
+      {
+        "id": "GO:0016491",
+        "label": "MolecularActivity",
+        "name": "oxidoreductase activity"
+      },
+      {
+        "id": "GO:0016616",
+        "label": "MolecularActivity",
+        "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
+      },
+      {
+        "id": "MESH:D011453",
+        "label": "ChemicalSubstance",
+        "name": "Prostaglandins"
+      },
+      {
+        "id": "GO:0070254",
+        "label": "BiologicalProcess",
+        "name": "mucus secretion"
+      },
+      {
+        "id": "GO:0008283",
+        "label": "BiologicalProcess",
+        "name": "cell population proliferation"
+      },
+      {
+        "id": "GO:0001696",
+        "label": "BiologicalProcess",
+        "name": "gastric acid secretion"
+      },
+      {
+        "id": "MESH:D010437",
+        "label": "Disease",
+        "name": "Peptic ulcer"
+      }
+    ],
+    "reference": "https://gut.bmj.com/content/11/4/344 https://www.sciencedirect.com/science/article/abs/pii/0039128X94900914 https://scholar.googleusercontent.com/scholar?q=cache:A3Q9QZ97ZyAJ:scholar.google.com/&hl=en&as_sdt=0,5 https://www.kegg.jp/entry/D01899 http://www.oeso.org/OESO/books/Vol_3_Eso_Mucosa/Articles/ART088.HTML https://europepmc.org/article/MED/30117204 https://pubmed.ncbi.nlm.nih.gov/2864318/ https://pubmed.ncbi.nlm.nih.gov/780088/ https://en.wikipedia.org/wiki/Carbenoxolone https://en.wikipedia.org/wiki/Enoxolone#Mechanism_of_action https://go.drugbank.com/drugs/DB02329#mechanism-of-action"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Perennial allergic rhinitis",
+      "disease_mesh": "MESH:D012221",
+      "drug": "mizolastine",
+      "drug_mesh": "MESH:C076170",
+      "drugbank": "DB:DB12523"
+    },
+    "links": [
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+        "key": "decreases activity of",
+        "source": "MESH:C076170",
+        "target": "UniProt:P35367"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P35367",
+        "target": "GO:0004969"
+      },
+      {
+        "key": "participates in",
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+        "target": "GO:0071420"
+      },
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+        "key": "positively correlated with",
+        "source": "GO:0071420",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D012221"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C076170",
+        "label": "Drug",
+        "name": "mizolastine"
+      },
+      {
+        "id": "UniProt:P35367",
+        "label": "Protein",
+        "name": "Histamine H1 receptor"
+      },
+      {
+        "id": "GO:0004969",
+        "label": "MolecularActivity",
+        "name": "histamine receptor activity"
+      },
+      {
+        "id": "GO:0071420",
+        "label": "BiologicalProcess",
+        "name": "cellular response to histamine"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "MESH:D012221",
+        "label": "Disease",
+        "name": "Perennial allergic rhinitis"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Mizolastine https://en.wikipedia.org/wiki/Antihistamine#H1-antihistamines"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
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+      {
+        "key": "negatively regulates",
+        "source": "DB:DB05812",
+        "target": "UniProt:P05093"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "DB:DB05812",
+        "target": "UniProt:P26439"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "DB:DB05812",
+        "target": "UniProt:P14060"
+      },
+      {
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+        "source": "UniProt:P05093",
+        "target": "GO:0006702"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P26439",
+        "target": "GO:0006702"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P14060",
+        "target": "GO:0006702"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05093",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P26439",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P14060",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006704",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006702",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0030088",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P05093",
+        "label": "Protein",
+        "name": "Steroid 17-alpha-hydroxylase/17,20 lyase"
+      },
+      {
+        "id": "UniProt:P26439",
+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2"
+      },
+      {
+        "id": "UniProt:P14060",
+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1"
+      },
+      {
+        "id": "GO:0006702",
+        "label": "BiologicalProcess",
+        "name": "androgen biosynthetic process"
+      },
+      {
+        "id": "GO:0006704",
+        "label": "BiologicalProcess",
+        "name": "glucocorticoid biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB05812#mechanism-of-action https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://clincancerres.aacrjournals.org/content/19/13/3353"
+  },
+  {
+    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also inhibits all these cytochrome P450s and can be useful in treating castration-resistant prostate cancers.",
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P15538"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08686"
+      },
+      {
+        "key": "decreases activity of",
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+        "target": "UniProt:P05177"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P11712"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08684"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P15538",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08686",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05177",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11712",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08684",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0008203",
+        "target": "GO:0061370"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0061370",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0030088",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P15538",
+        "label": "Protein",
+        "name": "Cytochrome P450 11B1, mitochondrial"
+      },
+      {
+        "id": "UniProt:P08686",
+        "label": "Protein",
+        "name": "Steroid 21-hydroxylase"
+      },
+      {
+        "id": "UniProt:P05177",
+        "label": "Protein",
+        "name": "Cytochrome P450 1A2"
+      },
+      {
+        "id": "UniProt:P11712",
+        "label": "Protein",
+        "name": "Cytochrome P450 2C9"
+      },
+      {
+        "id": "UniProt:P08684",
+        "label": "Protein",
+        "name": "Cytochrome P450 3A4"
+      },
+      {
+        "id": "GO:0008203",
+        "label": "BiologicalProcess",
+        "name": "cholesterol metabolic process"
+      },
+      {
+        "id": "GO:0061370",
+        "label": "BiologicalProcess",
+        "name": "testosterone biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+  },
+  {
+    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also inhibits all these cytochrome P450s and can be useful in treating castration-resistant prostate cancers.",
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
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+        "key": "decreases activity of",
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+        "target": "UniProt:P15538"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08686"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P05177"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P11712"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08684"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P15538",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08686",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05177",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11712",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08684",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006704",
+        "target": "GO:0061370"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0061370",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0030088",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P15538",
+        "label": "Protein",
+        "name": "Cytochrome P450 11B1, mitochondrial"
+      },
+      {
+        "id": "UniProt:P08686",
+        "label": "Protein",
+        "name": "Steroid 21-hydroxylase"
+      },
+      {
+        "id": "UniProt:P05177",
+        "label": "Protein",
+        "name": "Cytochrome P450 1A2"
+      },
+      {
+        "id": "UniProt:P11712",
+        "label": "Protein",
+        "name": "Cytochrome P450 2C9"
+      },
+      {
+        "id": "UniProt:P08684",
+        "label": "Protein",
+        "name": "Cytochrome P450 3A4"
+      },
+      {
+        "id": "GO:0006704",
+        "label": "BiologicalProcess",
+        "name": "glucocorticoid biosynthetic process"
+      },
+      {
+        "id": "GO:0061370",
+        "label": "BiologicalProcess",
+        "name": "testosterone biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+  },
+  {
+    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also acts as a partial antagonist of the androgen receptor (UniProt:P10275)",
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P10275"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P10275",
+        "target": "GO:0060769"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0060769",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P10275",
+        "label": "Protein",
+        "name": "Androgen receptor"
+      },
+      {
+        "id": "GO:0060769",
+        "label": "BiologicalProcess",
+        "name": "positive regulation of epithelial cell proliferation involved in prostate gland development"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/Androgen_receptor#Mechanism_of_action https://en.wikipedia.org/wiki/Androgen_deprivation_therapy#Methods_based_on_drugs https://www.kegg.jp/entry/D09701"
+  },
+  {
+    "comments": "DrugBank has this drug as a beta 1 antagonist but data elsewhere does not seem to support the anatagonism role (e.g. https://www.drugs.com/pro/terbutaline.html#s-34090-1, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1760 https://www.genome.jp/dbget-bin/www_bget?cpd:C07129)",
+    "directed": true,
+    "graph": {
+      "disease": "Tear film insufficiency",
+      "disease_mesh": "MESH:D015352",
+      "drug": "terbutaline",
+      "drug_mesh": "MESH:D013726",
+      "drugbank": "DB:DB00871"
+    },
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+      },
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+        "target": "GO:0050728"
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+      }
+    ],
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+        "id": "UniProt:P13945",
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+        "name": "Beta-3 adrenergic receptor"
+      },
+      {
+        "id": "UniProt:P07550",
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+        "name": "Beta-2 adrenergic receptor"
+      },
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+        "name": "negative regulation of inflammatory response"
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+        "id": "MESH:D015352",
+        "label": "Disease",
+        "name": "Tear film insufficiency"
+      }
+    ],
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+  },
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+      "drugbank": "DB:DB05812"
+    },
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+      },
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+        "target": "UniProt:P26439"
+      },
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+      }
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+        "label": "Drug",
+        "name": "delta4-abiraterone"
+      },
+      {
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+        "name": "Steroid 17-alpha-hydroxylase/17,20 lyase"
+      },
+      {
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+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2"
+      },
+      {
+        "id": "UniProt:P14060",
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+      },
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+        "label": "BiologicalProcess",
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+      },
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+        "name": "glucocorticoid biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
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+        "name": "Increased serum testosterone level"
+      },
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+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
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+  },
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+    },
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+      },
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+      },
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+      },
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+      },
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+      },
+      {
+        "key": "produces",
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+        "target": "CHEBI:16330"
+      },
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+      }
+    ],
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+        "label": "Drug",
+        "name": "delta4-abiraterone"
+      },
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+        "label": "Protein",
+        "name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1"
+      },
+      {
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+        "label": "Protein",
+        "name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2"
+      },
+      {
+        "id": "UniProt:Q9H8P0",
+        "label": "Protein",
+        "name": "Polyprenol reductase"
+      },
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+      },
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+        "label": "ChemicalSubstance",
+        "name": "17\u03b2-hydroxy-5\u03b1-androstan-3-one"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
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+  },
+  {
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D065631",
+      "drug": "mizolastine",
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+    },
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+      },
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+        "target": "MESH:D065631"
+      }
+    ],
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+        "name": "histamine receptor activity"
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+        "name": "cellular response to histamine"
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+        "name": "inflammatory response"
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+        "label": "Disease",
+        "name": "Allergic rhinitis"
+      }
+    ],
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+  },
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+    },
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+        "target": "UniProt:P15428"
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+      },
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+      },
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+        "target": "MESH:D011453"
+      },
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+      },
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+      },
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+      },
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+        "label": "Protein",
+        "name": "Corticosteroid 11-beta-dehydrogenase isozyme 1"
+      },
+      {
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+        "label": "Protein",
+        "name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]"
+      },
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+        "label": "MolecularActivity",
+        "name": "oxidoreductase activity"
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+        "label": "ChemicalSubstance",
+        "name": "Prostaglandins"
+      },
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+        "label": "BiologicalProcess",
+        "name": "mucus secretion"
+      },
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+        "id": "GO:0008283",
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+        "name": "cell population proliferation"
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+        "id": "GO:0001696",
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+        "name": "gastric acid secretion"
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+        "id": "MESH:D010437",
+        "label": "Disease",
+        "name": "Peptic ulcer"
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+  },
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+      "drugbank": "DB:DB12523"
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+      },
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+        "target": "MESH:D012221"
+      }
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+        "name": "cellular response to histamine"
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+        "label": "Disease",
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+    ],
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+        "target": "HP:0030088"
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+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
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+        "label": "Protein",
+        "name": "Steroid 17-alpha-hydroxylase/17,20 lyase"
+      },
+      {
+        "id": "UniProt:P26439",
+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2"
+      },
+      {
+        "id": "UniProt:P14060",
+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1"
+      },
+      {
+        "id": "GO:0006702",
+        "label": "BiologicalProcess",
+        "name": "androgen biosynthetic process"
+      },
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+        "id": "GO:0006704",
+        "label": "BiologicalProcess",
+        "name": "glucocorticoid biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB05812#mechanism-of-action https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://clincancerres.aacrjournals.org/content/19/13/3353"
+  },
+  {
+    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also inhibits all these cytochrome P450s and can be useful in treating castration-resistant prostate cancers.",
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
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+        "target": "UniProt:P15538"
+      },
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+        "target": "UniProt:P08686"
+      },
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+        "target": "UniProt:P05177"
+      },
+      {
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+        "target": "UniProt:P11712"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08684"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P15538",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08686",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05177",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11712",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08684",
+        "target": "GO:0008203"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0008203",
+        "target": "GO:0061370"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0061370",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0030088",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P15538",
+        "label": "Protein",
+        "name": "Cytochrome P450 11B1, mitochondrial"
+      },
+      {
+        "id": "UniProt:P08686",
+        "label": "Protein",
+        "name": "Steroid 21-hydroxylase"
+      },
+      {
+        "id": "UniProt:P05177",
+        "label": "Protein",
+        "name": "Cytochrome P450 1A2"
+      },
+      {
+        "id": "UniProt:P11712",
+        "label": "Protein",
+        "name": "Cytochrome P450 2C9"
+      },
+      {
+        "id": "UniProt:P08684",
+        "label": "Protein",
+        "name": "Cytochrome P450 3A4"
+      },
+      {
+        "id": "GO:0008203",
+        "label": "BiologicalProcess",
+        "name": "cholesterol metabolic process"
+      },
+      {
+        "id": "GO:0061370",
+        "label": "BiologicalProcess",
+        "name": "testosterone biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+  },
+  {
+    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also inhibits all these cytochrome P450s and can be useful in treating castration-resistant prostate cancers.",
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P15538"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08686"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P05177"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P11712"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P08684"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P15538",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08686",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05177",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11712",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08684",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006704",
+        "target": "GO:0061370"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0061370",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0030088",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P15538",
+        "label": "Protein",
+        "name": "Cytochrome P450 11B1, mitochondrial"
+      },
+      {
+        "id": "UniProt:P08686",
+        "label": "Protein",
+        "name": "Steroid 21-hydroxylase"
+      },
+      {
+        "id": "UniProt:P05177",
+        "label": "Protein",
+        "name": "Cytochrome P450 1A2"
+      },
+      {
+        "id": "UniProt:P11712",
+        "label": "Protein",
+        "name": "Cytochrome P450 2C9"
+      },
+      {
+        "id": "UniProt:P08684",
+        "label": "Protein",
+        "name": "Cytochrome P450 3A4"
+      },
+      {
+        "id": "GO:0006704",
+        "label": "BiologicalProcess",
+        "name": "glucocorticoid biosynthetic process"
+      },
+      {
+        "id": "GO:0061370",
+        "label": "BiologicalProcess",
+        "name": "testosterone biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+  },
+  {
+    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also acts as a partial antagonist of the androgen receptor (UniProt:P10275)",
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "DB:DB05812",
+        "target": "UniProt:P10275"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P10275",
+        "target": "GO:0060769"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0060769",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "UniProt:P10275",
+        "label": "Protein",
+        "name": "Androgen receptor"
+      },
+      {
+        "id": "GO:0060769",
+        "label": "BiologicalProcess",
+        "name": "positive regulation of epithelial cell proliferation involved in prostate gland development"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/Androgen_receptor#Mechanism_of_action https://en.wikipedia.org/wiki/Androgen_deprivation_therapy#Methods_based_on_drugs https://www.kegg.jp/entry/D09701"
+  },
+  {
+    "comments": "DrugBank has this drug as a beta 1 antagonist but data elsewhere does not seem to support the anatagonism role (e.g. https://www.drugs.com/pro/terbutaline.html#s-34090-1, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1760 https://www.genome.jp/dbget-bin/www_bget?cpd:C07129)",
+    "directed": true,
+    "graph": {
+      "disease": "Tear film insufficiency",
+      "disease_mesh": "MESH:D015352",
+      "drug": "terbutaline",
+      "drug_mesh": "MESH:D013726",
+      "drugbank": "DB:DB00871"
+    },
+    "links": [
+      {
+        "key": "positively regulates",
+        "source": "MESH:D013726",
+        "target": "UniProt:P13945"
+      },
+      {
+        "key": "positively regulates",
+        "source": "MESH:D013726",
+        "target": "UniProt:P07550"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "UniProt:P13945",
+        "target": "GO:0050728"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "UniProt:P07550",
+        "target": "GO:0050728"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0050728",
+        "target": "MESH:D015352"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D013726",
+        "label": "Drug",
+        "name": "terbutaline"
+      },
+      {
+        "id": "UniProt:P13945",
+        "label": "Protein",
+        "name": "Beta-3 adrenergic receptor"
+      },
+      {
+        "id": "UniProt:P07550",
+        "label": "Protein",
+        "name": "Beta-2 adrenergic receptor"
+      },
+      {
+        "id": "GO:0050728",
+        "label": "BiologicalProcess",
+        "name": "negative regulation of inflammatory response"
+      },
+      {
+        "id": "MESH:D015352",
+        "label": "Disease",
+        "name": "Tear film insufficiency"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00871#mechanism-of-action https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345890/ https://europepmc.org/article/MED/23360156"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
+    "links": [
+      {
+        "key": "derives into",
+        "source": "DB:DB05812",
+        "target": "MESH:C000600172"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C000600172",
+        "target": "UniProt:P05093"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C000600172",
+        "target": "UniProt:P26439"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C000600172",
+        "target": "UniProt:P14060"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05093",
+        "target": "GO:0006702"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P26439",
+        "target": "GO:0006702"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P14060",
+        "target": "GO:0006702"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P05093",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P26439",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P14060",
+        "target": "GO:0006704"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006704",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006702",
+        "target": "HP:0030088"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0030088",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "MESH:C000600172",
+        "label": "Drug",
+        "name": "delta4-abiraterone"
+      },
+      {
+        "id": "UniProt:P05093",
+        "label": "Protein",
+        "name": "Steroid 17-alpha-hydroxylase/17,20 lyase"
+      },
+      {
+        "id": "UniProt:P26439",
+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2"
+      },
+      {
+        "id": "UniProt:P14060",
+        "label": "Protein",
+        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1"
+      },
+      {
+        "id": "GO:0006702",
+        "label": "BiologicalProcess",
+        "name": "androgen biosynthetic process"
+      },
+      {
+        "id": "GO:0006704",
+        "label": "BiologicalProcess",
+        "name": "glucocorticoid biosynthetic process"
+      },
+      {
+        "id": "HP:0030088",
+        "label": "PhenotypicFeature",
+        "name": "Increased serum testosterone level"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/%CE%944-Abiraterone https://www.nature.com/articles/nrurol.2016.101 https://www.medchemexpress.com/D4-abiraterone.html"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Malignant tumor of prostate",
+      "disease_mesh": "MESH:D011471",
+      "drug": "abiraterone acetate",
+      "drug_mesh": "MESH:D000069501,MESH:C089740",
+      "drugbank": "DB:DB05812"
+    },
+    "links": [
+      {
+        "key": "derives into",
+        "source": "DB:DB05812",
+        "target": "MESH:C000600172"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C000600172",
+        "target": "UniProt:P18405"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C000600172",
+        "target": "UniProt:P31213"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C000600172",
+        "target": "UniProt:Q9H8P0"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P18405",
+        "target": "GO:0033764"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P31213",
+        "target": "GO:0033764"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q9H8P0",
+        "target": "GO:0033764"
+      },
+      {
+        "key": "produces",
+        "source": "GO:0033764",
+        "target": "CHEBI:16330"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "CHEBI:16330",
+        "target": "MESH:D011471"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "DB:DB05812",
+        "label": "Drug",
+        "name": "abiraterone acetate"
+      },
+      {
+        "id": "MESH:C000600172",
+        "label": "Drug",
+        "name": "delta4-abiraterone"
+      },
+      {
+        "id": "UniProt:P18405",
+        "label": "Protein",
+        "name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1"
+      },
+      {
+        "id": "UniProt:P31213",
+        "label": "Protein",
+        "name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2"
+      },
+      {
+        "id": "UniProt:Q9H8P0",
+        "label": "Protein",
+        "name": "Polyprenol reductase"
+      },
+      {
+        "id": "GO:0033764",
+        "label": "MolecularActivity",
+        "name": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
+      },
+      {
+        "id": "CHEBI:16330",
+        "label": "ChemicalSubstance",
+        "name": "17\u03b2-hydroxy-5\u03b1-androstan-3-one"
+      },
+      {
+        "id": "MESH:D011471",
+        "label": "Disease",
+        "name": "Malignant tumor of prostate"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/%CE%944-Abiraterone https://www.nature.com/articles/nrurol.2016.101 https://www.medchemexpress.com/D4-abiraterone.html https://en.wikipedia.org/wiki/Dihydrotestosterone#Biological_function https://en.wikipedia.org/wiki/5%CE%B1-Reductase"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Influenza",
+      "disease_mesh": "MESH:D007251",
+      "drug": "oseltamivir",
+      "drug_mesh": "MESH:C535162,MESH:C403132,MESH:D053139",
+      "drugbank": "DB:DB00198"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "DB:DB00198",
+        "target": "UniProt:P11485"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11485",
+        "target": "GO:0004308"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0004308",
+        "target": "GO:0140374"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0140374",
+        "target": "NCBITaxon:380985"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:380985",
+        "target": "MESH:D007251"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
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+        "id": "DB:DB00198",
+        "label": "Drug",
+        "name": "Oseltamivir"
+      },
+      {
+        "id": "UniProt:P11485",
+        "label": "Protein",
+        "name": "Neuraminidase"
+      },
+      {
+        "id": "GO:0004308",
+        "label": "BiologicalProcess",
+        "name": "exo-alpha-sialidase activity"
+      },
+      {
+        "id": "GO:0140374",
+        "label": "BiologicalProcess",
+        "name": "viral budding from plasma membrane"
+      },
+      {
+        "id": "NCBITaxon:380985",
+        "label": "OrganismTaxon",
+        "name": "Influenza A virus (A/Chile/1/1983(H1N1))"
+      },
+      {
+        "id": "MESH:D007251",
+        "label": "Disease",
+        "name": "Influenza"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00198#mechanism-of-action https://en.wikipedia.org/wiki/Oseltamivir#Mechanism_of_action"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Panic disorder",
+      "disease_mesh": "MESH:D016584",
+      "drug": "venlafaxine",
+      "drug_mesh": "MESH:D000069470",
+      "drugbank": "DB:DB00285"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D000069470",
+        "target": "UniProt:P31645"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P31645",
+        "target": "GO:0051610"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0051610",
+        "target": "MESH:D016584"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D000069470",
+        "label": "Drug",
+        "name": "venlafaxine"
+      },
+      {
+        "id": "UniProt:P31645",
+        "label": "Protein",
+        "name": "Sodium-dependent serotonin transporter"
+      },
+      {
+        "id": "GO:0051610",
+        "label": "BiologicalProcess",
+        "name": "serotonin uptake"
+      },
+      {
+        "id": "MESH:D016584",
+        "label": "Disease",
+        "name": "Panic disorder"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00285#mechanism-of-action https://en.wikipedia.org/wiki/Venlafaxine#Mechanism_of_action https://en.wikipedia.org/wiki/Panic_disorder#Medication"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Panic disorder",
+      "disease_mesh": "MESH:D016584",
+      "drug": "venlafaxine",
+      "drug_mesh": "MESH:D000069470",
+      "drugbank": "DB:DB00285"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D000069470",
+        "target": "UniProt:P23975"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P23975",
+        "target": "GO:0051620"
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+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D002117",
+        "target": "UniProt:P01270"
+      },
+      {
+        "key": "decreases secretion of",
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+      },
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+        "target": "MESH:D016226"
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+        "source": "MESH:D016226",
+        "target": "MESH:D006961"
+      }
+    ],
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+    "nodes": [
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+        "id": "MESH:C008088",
+        "label": "Drug",
+        "name": "alfacalcidol"
+      },
+      {
+        "id": "UniProt:P41180",
+        "label": "Protein",
+        "name": "Calcium sensing receptor"
+      },
+      {
+        "id": "UniProt:O15528",
+        "label": "Protein",
+        "name": "25-hydroxylase"
+      },
+      {
+        "id": "MESH:D002117",
+        "label": "ChemicalSubstance",
+        "name": "calcitriol"
+      },
+      {
+        "id": "UniProt:P01270",
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+        "name": "parathyroid hormone"
+      },
+      {
+        "id": "MESH:D002118",
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+        "name": "calcium"
+      },
+      {
+        "id": "MESH:D016226",
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+        "name": "phosphorus"
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+      {
+        "id": "MESH:D006961",
+        "label": "Disease",
+        "name": "Hyperparathyroidism"
+      }
+    ],
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+    ],
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+        "id": "MESH:D011453",
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+        "id": "MESH:D004485",
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+        "id": "MESH:D011453",
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+      {
+        "id": "GO:0042311",
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+      {
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+        "target": "MESH:D006504"
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+        "id": "GO:0044557",
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+      },
+      {
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+      {
+        "id": "MESH:D006504",
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+        "target": "MESH:D016780"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D011319",
+        "label": "Drug",
+        "name": "primaquine"
+      },
+      {
+        "id": "GO:0006979",
+        "label": "BiologicalProcess",
+        "name": "response to oxidative stress"
+      },
+      {
+        "id": "GO:0042775",
+        "label": "BiologicalProcess",
+        "name": "mitochondrial ATP synthesis coupled electron transport"
+      },
+      {
+        "id": "NCBITaxon:5855",
+        "label": "OrganismTaxon",
+        "name": "Plasmodium vivax"
+      },
+      {
+        "id": "MESH:D016780",
+        "label": "Disease",
+        "name": "Vivax malaria"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01087#BE0004805 https://en.wikipedia.org/wiki/Primaquine#Mechanism_of_action"
+  },
+  {
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D006973",
+      "drug": "cilazapril",
+      "drug_mesh": "MESH:C045980,MESH:D017315",
+      "drugbank": "DB:DB01340"
+    },
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+        "target": "UniProt:P12821"
+      },
+      {
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+        "target": "MESH:D000804"
+      },
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+        "source": "MESH:D000804",
+        "target": "MESH:D014661"
+      },
+      {
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+        "source": "MESH:D014661",
+        "target": "MESH:D006973"
+      }
+    ],
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+        "label": "Drug",
+        "name": "cilazapril"
+      },
+      {
+        "id": "UniProt:P12821",
+        "label": "Protein",
+        "name": "Angiotensin-converting enzyme"
+      },
+      {
+        "id": "MESH:D000804",
+        "label": "ChemicalSubstance",
+        "name": "Angiotensin II"
+      },
+      {
+        "id": "MESH:D014661",
+        "label": "Disease",
+        "name": "vasoconstriction"
+      },
+      {
+        "id": "MESH:D006973",
+        "label": "Disease",
+        "name": "hypertensive disorder"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01340"
+  },
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+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D054179",
+      "drug": "icatibant",
+      "drug_mesh": "MESH:C065679",
+      "drugbank": "DB:DB06196"
+    },
+    "links": [
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+        "key": "decreases activity of",
+        "source": "MESH:C065679",
+        "target": "UniProt:P30411"
+      },
+      {
+        "key": "molecularly interacts with",
+        "source": "UniProt:P30411",
+        "target": "MESH:D001920"
+      },
+      {
+        "key": "contributes to",
+        "source": "MESH:D001920",
+        "target": "GO:0043117"
+      },
+      {
+        "key": "has phenotype",
+        "source": "GO:0043117",
+        "target": "HP:0000969"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0000969",
+        "target": "MESH:D054179"
+      }
+    ],
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+        "label": "Drug",
+        "name": "icatibant"
+      },
+      {
+        "id": "UniProt:P30411",
+        "label": "Protein",
+        "name": "B2 bradykinin receptor"
+      },
+      {
+        "id": "MESH:D001920",
+        "label": "ChemicalSubstance",
+        "name": "bradykinin"
+      },
+      {
+        "id": "GO:0043117",
+        "label": "BiologicalProcess",
+        "name": "positive regulation of vascular permeability"
+      },
+      {
+        "id": "HP:0000969",
+        "label": "PhenotypicFeature",
+        "name": "edema"
+      },
+      {
+        "id": "MESH:D054179",
+        "label": "Disease",
+        "name": "hereditary angioneurotic edema"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB06196#BE0003513 https://en.wikipedia.org/wiki/Hereditary_angioedema"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Homocystinuria",
+      "disease_mesh": "MESH:D006712",
+      "drug": "betaine",
+      "drug_mesh": "MESH:D001622",
+      "drugbank": "DB:DB06756"
+    },
+    "links": [
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+        "key": "decreases abundance of",
+        "source": "MESH:D001622",
+        "target": "MESH:D006710"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D006710",
+        "target": "MESH:D006712"
+      }
+    ],
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+        "id": "MESH:D001622",
+        "label": "Drug",
+        "name": "Betaine"
+      },
+      {
+        "id": "MESH:D006710",
+        "label": "ChemicalSubstance",
+        "name": "Homocysteine"
+      },
+      {
+        "id": "MESH:D006712",
+        "label": "Disease",
+        "name": "Homocystinuria"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB06756"
+  },
+  {
+    "comment": "Betaine is not a standard treatment for cystitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895837/",
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D003556",
+      "drug": "Betaine",
+      "drug_mesh": "MESH:D001622",
+      "drugbank": "DB:DB06756"
+    },
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+        "key": "contributes to",
+        "source": "MESH:D001622",
+        "target": "HP:0012072"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "HP:0012072",
+        "target": "MESH:D001437"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D001437",
+        "target": "MESH:D003556"
+      }
+    ],
+    "multigraph": true,
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+        "id": "MESH:D001622",
+        "label": "Drug",
+        "name": "Betaine"
+      },
+      {
+        "id": "HP:0012072",
+        "label": "PhenotypicFeature",
+        "name": "Acidic urine"
+      },
+      {
+        "id": "MESH:D001437",
+        "label": "Disease",
+        "name": "Bacteriuria"
+      },
+      {
+        "id": "MESH:D003556",
+        "label": "Disease",
+        "name": "Cystitis"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB06756 https://pubmed.ncbi.nlm.nih.gov/31604680/ https://www.aafp.org/afp/2011/1201/p1234.html"
+  },
+  {
+    "comment": "Effective only for skin itching related to scabies",
+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D011537",
+      "drug": "benzyl alcohol",
+      "drug_mesh": "MESH:D019905",
+      "drugbank": "DB:DB06770"
+    },
+    "links": [
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+        "key": "decreases abundance of",
+        "source": "MESH:D019905",
+        "target": "NCBITaxon:52283"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:52283",
+        "target": "MESH:D011537"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
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+        "id": "MESH:D019905",
+        "label": "Drug",
+        "name": "Benzyl alcohol"
+      },
+      {
+        "id": "NCBITaxon:52283",
+        "label": "OrganismTaxon",
+        "name": "Sarcoptes scabiei"
+      },
+      {
+        "id": "MESH:D011537",
+        "label": "Disease",
+        "name": "Itching of skin"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB06770"
+  },
+  {
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+    "graph": {
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+      "drug": "Limaprost",
+      "drug_mesh": "MESH:C525749,MESH:C025090,MESH:C059238",
+      "drugbank": "DB:DB09211"
+    },
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+        "key": "increases activity of",
+        "source": "DB:DB09211",
+        "target": "UniProt:P43116"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P43116",
+        "target": "REACT:R-HSA-372790"
+      },
+      {
+        "key": "increases activity of",
+        "source": "REACT:R-HSA-372790",
+        "target": "UniProt:B7Z2C7"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "UniProt:B7Z2C7",
+        "target": "CHEBI:17489"
+      },
+      {
+        "key": "positively regulates",
+        "source": "CHEBI:17489",
+        "target": "GO:0044557"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0044557",
+        "target": "MESH:D014661"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D014661",
+        "target": "MESH:D013919"
+      }
+    ],
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+        "label": "Drug",
+        "name": "Limaprost"
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+      {
+        "id": "UniProt:P43116",
+        "label": "Protein",
+        "name": "Prostaglandin E2 receptor EP2 subtype"
+      },
+      {
+        "id": "REACT:R-HSA-372790",
+        "label": "Pathway",
+        "name": "Signaling by GPCR"
+      },
+      {
+        "id": "UniProt:B7Z2C7",
+        "label": "Protein",
+        "name": "Adenylate cyclase"
+      },
+      {
+        "id": "CHEBI:17489",
+        "label": "ChemicalSubstance",
+        "name": "3',5'-cyclic AMP"
+      },
+      {
+        "id": "GO:0044557",
+        "label": "BiologicalProcess",
+        "name": "Relaxation of smooth muscle"
+      },
+      {
+        "id": "MESH:D014661",
+        "label": "Disease",
+        "name": "Vasoconstriction"
+      },
+      {
+        "id": "MESH:D013919",
+        "label": "Disease",
+        "name": "Thromboangiitis obliterans"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB09211 https://en.wikipedia.org/wiki/Thromboangiitis_obliterans"
+  },
+  {
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+    "graph": {
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+      "disease_mesh": "MESH:D018781",
+      "drug": "butalbital",
+      "drug_mesh": "MESH:C004470",
+      "drugbank": "DB:DB00241"
+    },
+    "links": [
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+        "key": "increases activity of",
+        "source": "MESH:C004470",
+        "target": "UniProt:P14867"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C004470",
+        "target": "UniProt:P47869"
+      },
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+        "source": "MESH:C004470",
+        "target": "UniProt:P34903"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C004470",
+        "target": "UniProt:P48169"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C004470",
+        "target": "UniProt:P31644"
+      },
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+        "key": "positively regulates",
+        "source": "UniProt:P14867",
+        "target": "GO:0022851"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P47869",
+        "target": "GO:0022851"
+      },
+      {
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+        "source": "UniProt:P34903",
+        "target": "GO:0022851"
+      },
+      {
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+        "source": "UniProt:P48169",
+        "target": "GO:0022851"
+      },
+      {
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+        "source": "UniProt:P31644",
+        "target": "GO:0022851"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0022851",
+        "target": "GO:0060081"
+      },
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+        "target": "GO:0019228"
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+        "target": "GO:0050806"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0050806",
+        "target": "MESH:D018781"
+      }
+    ],
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+        "label": "Drug",
+        "name": "Butalbital"
+      },
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+        "label": "Protein",
+        "name": "Gamma-aminobutyric acid receptor subunit alpha-1"
+      },
+      {
+        "id": "UniProt:P47869",
+        "label": "Protein",
+        "name": "Gamma-aminobutyric acid receptor subunit alpha-2"
+      },
+      {
+        "id": "UniProt:P34903",
+        "label": "Protein",
+        "name": "Gamma-aminobutyric acid receptor subunit alpha-3"
+      },
+      {
+        "id": "UniProt:P48169",
+        "label": "Protein",
+        "name": "Gamma-aminobutyric acid receptor subunit alpha-4"
+      },
+      {
+        "id": "UniProt:P31644",
+        "label": "Protein",
+        "name": "Gamma-aminobutyric acid receptor subunit alpha-5"
+      },
+      {
+        "id": "GO:0022851",
+        "label": "MolecularActivity",
+        "name": "GABA-gated chloride ion channel activity"
+      },
+      {
+        "id": "GO:0060081",
+        "label": "BiologicalProcess",
+        "name": "Membrane hyperpolarization"
+      },
+      {
+        "id": "GO:0019228",
+        "label": "BiologicalProcess",
+        "name": "Neuronal action potential"
+      },
+      {
+        "id": "GO:0050806",
+        "label": "BiologicalProcess",
+        "name": "Positive regulation of synaptic transmission"
+      },
+      {
+        "id": "MESH:D018781",
+        "label": "Disease",
+        "name": "Tension-type headache"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00241 https://en.wikipedia.org/wiki/Tension_headache"
+  },
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+      "disease_mesh": "MESH:D000690",
+      "drug": "riluzole",
+      "drug_mesh": "MESH:D019782",
+      "drugbank": "DB:DB00740"
+    },
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+        "source": "MESH:D019782",
+        "target": "UniProt:Q14524"
+      },
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+        "target": "GO:0004972"
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+        "target": "GO:0098719"
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+      {
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+        "target": "GO:0070509"
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+      {
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+        "target": "GO:0090280"
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+        "source": "GO:0090280",
+        "target": "GO:0051899"
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+        "target": "GO:0061535"
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+        "target": "GO:0004972"
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+        "key": "positively correlated with",
+        "source": "GO:0070509",
+        "target": "GO:0070997"
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+      {
+        "key": "occurs in",
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+        "target": "MESH:D000690"
+      }
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+        "label": "Drug",
+        "name": "Riluzole"
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+        "label": "Protein",
+        "name": "Sodium channel protein type 5 subunit alpha"
+      },
+      {
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+        "label": "MolecularActivity",
+        "name": "NMDA glutamate receptor activity"
+      },
+      {
+        "id": "GO:0098719",
+        "label": "BiologicalProcess",
+        "name": "Sodium ion import across plasma membrane"
+      },
+      {
+        "id": "GO:0061535",
+        "label": "BiologicalProcess",
+        "name": "Glutamate secretion, neurotransmission"
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+      {
+        "id": "GO:0070509",
+        "label": "BiologicalProcess",
+        "name": "Transmembrane calcium influx"
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+      {
+        "id": "GO:0090280",
+        "label": "BiologicalProcess",
+        "name": "Positive regulation of calcium ion import"
+      },
+      {
+        "id": "GO:0051899",
+        "label": "BiologicalProcess",
+        "name": "Membrane depolarization"
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+      {
+        "id": "GO:0070997",
+        "label": "BiologicalProcess",
+        "name": "Neuronal cell death"
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+      {
+        "id": "MESH:D000690",
+        "label": "Disease",
+        "name": "Amyotrophic lateral sclerosis"
+      }
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+        "target": "UniProt:P55017"
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+        "target": "GO:0070294"
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+        "target": "MESH:D004487"
+      }
+    ],
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+        "label": "Drug",
+        "name": "Hydrochlorothiazide"
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+        "label": "Protein",
+        "name": "Solute carrier family 12 member 3"
+      },
+      {
+        "id": "GO:0070294",
+        "label": "BiologicalProcess",
+        "name": "Renal sodium ion absorption"
+      },
+      {
+        "id": "GO:0003092",
+        "label": "BiologicalProcess",
+        "name": "Renal water retention"
+      },
+      {
+        "id": "MESH:D004487",
+        "label": "Disease",
+        "name": "Edema"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00999"
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+      "drug_mesh": "MESH:D006852",
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+        "target": "UniProt:P55017"
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+        "target": "GO:0003092"
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+        "target": "HP:0011104"
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+        "source": "HP:0011104",
+        "target": "GO:0045777"
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+        "key": "affects risk for",
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+        "target": "MESH:D006973"
+      }
+    ],
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+        "label": "Drug",
+        "name": "Hydrochlorothiazide"
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+        "label": "Protein",
+        "name": "Solute carrier family 12 member 3"
+      },
+      {
+        "id": "GO:0070294",
+        "label": "BiologicalProcess",
+        "name": "Renal sodium ion absorption"
+      },
+      {
+        "id": "GO:0003092",
+        "label": "BiologicalProcess",
+        "name": "Renal water retention"
+      },
+      {
+        "id": "HP:0011104",
+        "label": "PhenotypicFeature",
+        "name": "Abnormality of blood volume homeostasis"
+      },
+      {
+        "id": "GO:0045777",
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+      },
+      {
+        "id": "MESH:D006973",
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+        "name": "Hypertensive disorder"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00999"
+  },
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+    },
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+      },
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+      },
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+    ],
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+        "name": "Type-1 angiotensin II receptor"
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+      {
+        "id": "MESH:D000804",
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+        "name": "Angiotensin II"
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+        "id": "MESH:D014661",
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+    ],
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+    },
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+    ],
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+    ],
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+    },
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+      },
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+      },
+      {
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+    ],
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+      },
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+        "label": "Protein",
+        "name": "Estrogen receptor alpha"
+      },
+      {
+        "id": "MESH:D004967",
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+        "name": "Estrogen"
+      },
+      {
+        "id": "MESH:D059268",
+        "label": "Disease",
+        "name": "Atrophic vaginitis"
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+    ],
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+    },
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+      },
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+      }
+    ],
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+      {
+        "id": "UniProt:A9UF02",
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+      },
+      {
+        "id": "MESH:D001752",
+        "label": "Disease",
+        "name": "Blastic phase of chronic myeloid leukemia"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB06616"
+  },
+  {
+    "comment": "Withdrawn",
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+  },
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+        "label": "Disease",
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+        "name": "Quinone Reductases"
+      },
+      {
+        "id": "GO:0009274",
+        "label": "CellularComponent",
+        "name": "peptidoglycan-based cell wall"
+      },
+      {
+        "id": "GO:0045272",
+        "label": "CellularComponent",
+        "name": "plasma membrane respiratory chain complex I"
+      },
+      {
+        "id": "NCBITaxon:1280",
+        "label": "OrganismTaxon",
+        "name": "Staphylococcus aureus"
+      },
+      {
+        "id": "MESH:D007634",
+        "label": "Disease",
+        "name": "Keratitis"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00781#mechanism-of-action https://en.wikipedia.org/wiki/Polymyxin_B#Mechanism_of_action https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355641/"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Urinary tract infectious disease",
+      "disease_mesh": "MESH:D014552",
+      "drug": "fosfomycin",
+      "drug_mesh": "MESH:D005578",
+      "drugbank": "DB:DB00828"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D005578",
+        "target": "UniProt:P0A749"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P0A749",
+        "target": "GO:0019277"
+      },
+      {
+        "key": "part of",
+        "source": "GO:0019277",
+        "target": "GO:0009274"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0009274",
+        "target": "NCBITaxon:562"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:562",
+        "target": "MESH:D014552"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D005578",
+        "label": "Drug",
+        "name": "fosfomycin"
+      },
+      {
+        "id": "UniProt:P0A749",
+        "label": "Protein",
+        "name": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase"
+      },
+      {
+        "id": "GO:0019277",
+        "label": "BiologicalProcess",
+        "name": "UDP-N-acetylgalactosamine biosynthetic process"
+      },
+      {
+        "id": "GO:0009274",
+        "label": "CellularComponent",
+        "name": "peptidoglycan-based cell wall"
+      },
+      {
+        "id": "NCBITaxon:562",
+        "label": "OrganismTaxon",
+        "name": "Escherichia coli"
+      },
+      {
+        "id": "MESH:D014552",
+        "label": "Disease",
+        "name": "Urinary tract infectious disease"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00828#mechanism-of-action https://en.wikipedia.org/wiki/Fosfomycin#Mechanism_of_action"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Parkinson's disease",
+      "disease_mesh": "MESH:D010300",
+      "drug": "entacapone",
+      "drug_mesh": "MESH:C071192",
+      "drugbank": "DB:DB00494"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C071192",
+        "target": "UniProt:P21964"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P21964",
+        "target": "GO:0102084"
+      },
+      {
+        "key": "decreases abundance of",
+        "source": "GO:0102084",
+        "target": "CHEBI:15765"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "CHEBI:15765",
+        "target": "GO:0001963"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0001963",
+        "target": "MESH:D010300"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C071192",
+        "label": "Drug",
+        "name": "entacapone"
+      },
+      {
+        "id": "UniProt:P21964",
+        "label": "Protein",
+        "name": "Catechol O-methyltransferase"
+      },
+      {
+        "id": "GO:0102084",
+        "label": "MolecularActivity",
+        "name": "L-dopa O-methyltransferase activity"
+      },
+      {
+        "id": "CHEBI:15765",
+        "label": "ChemicalSubstance",
+        "name": "L-dopa"
+      },
+      {
+        "id": "GO:0001963",
+        "label": "BiologicalProcess",
+        "name": "synaptic transmission, dopaminergic"
+      },
+      {
+        "id": "MESH:D010300",
+        "label": "Disease",
+        "name": "Parkinson's disease"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00494#mechanism-of-action https://en.wikipedia.org/wiki/Entacapone#Mechanism_of_action"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Hypophosphatemia",
+      "disease_mesh": "MESH:D017674",
+      "drug": "calcitriol",
+      "drug_mesh": "MESH:D002117",
+      "drugbank": "DB:DB00136"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D002117",
+        "target": "UniProt:P11473"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11473",
+        "target": "GO:0060558"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0060558",
+        "target": "GO:0055074"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0055074",
+        "target": "GO:0055062"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0055062",
+        "target": "MESH:D017674"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002117",
+        "label": "Drug",
+        "name": "calcitriol"
+      },
+      {
+        "id": "UniProt:P11473",
+        "label": "Protein",
+        "name": "Vitamin D3 receptor"
+      },
+      {
+        "id": "GO:0060558",
+        "label": "BiologicalProcess",
+        "name": "regulation of calcidiol 1-monooxygenase activity"
+      },
+      {
+        "id": "GO:0055074",
+        "label": "BiologicalProcess",
+        "name": "calcium ion homeostasis"
+      },
+      {
+        "id": "GO:0055062",
+        "label": "BiologicalProcess",
+        "name": "phosphate ion homeostasis"
+      },
+      {
+        "id": "MESH:D017674",
+        "label": "Disease",
+        "name": "Hypophosphatemia"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Calcitriol#Mechanism_of_action https://pubmed.ncbi.nlm.nih.gov/23713873/ https://www.targetvalidation.org/evidence/ENSG00000111424/HP_0002148?view=sec:known_drug https://en.wikipedia.org/wiki/Hypophosphatemia#Causes https://go.drugbank.com/drugs/DB00136#description"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Hypocalcemia",
+      "disease_mesh": "MESH:D006996",
+      "drug": "calcitriol",
+      "drug_mesh": "MESH:D002117",
+      "drugbank": "DB:DB00136"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D002117",
+        "target": "UniProt:P11473"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11473",
+        "target": "GO:0060558"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0060558",
+        "target": "GO:0055074"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0055074",
+        "target": "MESH:D006996"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002117",
+        "label": "Drug",
+        "name": "calcitriol"
+      },
+      {
+        "id": "UniProt:P11473",
+        "label": "Protein",
+        "name": "Vitamin D3 receptor"
+      },
+      {
+        "id": "GO:0060558",
+        "label": "BiologicalProcess",
+        "name": "regulation of calcidiol 1-monooxygenase activity"
+      },
+      {
+        "id": "GO:0055074",
+        "label": "BiologicalProcess",
+        "name": "calcium ion homeostasis"
+      },
+      {
+        "id": "MESH:D006996",
+        "label": "Disease",
+        "name": "Hypocalcemia"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Calcitriol#Mechanism_of_action https://pubmed.ncbi.nlm.nih.gov/23713873/ https://www.targetvalidation.org/evidence/ENSG00000111424/HP_0002901?view=sec:known_drug https://go.drugbank.com/drugs/DB00136#description https://en.wikipedia.org/wiki/Hypocalcaemia#Management"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Hypoparathyroidism",
+      "disease_mesh": "MESH:D007011",
+      "drug": "calcitriol",
+      "drug_mesh": "MESH:D002117",
+      "drugbank": "DB:DB00136"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D002117",
+        "target": "UniProt:P11473"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11473",
+        "target": "GO:0060558"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0060558",
+        "target": "GO:0055074"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0055074",
+        "target": "HP:0004363"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0004363",
+        "target": "MESH:D007011"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002117",
+        "label": "Drug",
+        "name": "calcitriol"
+      },
+      {
+        "id": "UniProt:P11473",
+        "label": "Protein",
+        "name": "Vitamin D3 receptor"
+      },
+      {
+        "id": "GO:0060558",
+        "label": "BiologicalProcess",
+        "name": "regulation of calcidiol 1-monooxygenase activity"
+      },
+      {
+        "id": "GO:0055074",
+        "label": "BiologicalProcess",
+        "name": "calcium ion homeostasis"
+      },
+      {
+        "id": "HP:0004363",
+        "label": "PhenotypicFeature",
+        "name": "Abnormal circulating calcium concentration"
+      },
+      {
+        "id": "MESH:D007011",
+        "label": "Disease",
+        "name": "Hypoparathyroidism"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Calcitriol#Mechanism_of_action https://pubmed.ncbi.nlm.nih.gov/23713873/ https://en.wikipedia.org/wiki/Hypoparathyroidism#Treatment https://go.drugbank.com/drugs/DB00136#description"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Renal osteodystrophy",
+      "disease_mesh": "MESH:D012080",
+      "drug": "calcitriol",
+      "drug_mesh": "MESH:D002117",
+      "drugbank": "DB:DB00136"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D002117",
+        "target": "UniProt:P11473"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P11473",
+        "target": "GO:0060558"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0060558",
+        "target": "GO:0055074"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0055074",
+        "target": "HP:0004363"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0004363",
+        "target": "MESH:D012080"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002117",
+        "label": "Drug",
+        "name": "calcitriol"
+      },
+      {
+        "id": "UniProt:P11473",
+        "label": "Protein",
+        "name": "Vitamin D3 receptor"
+      },
+      {
+        "id": "GO:0060558",
+        "label": "BiologicalProcess",
+        "name": "regulation of calcidiol 1-monooxygenase activity"
+      },
+      {
+        "id": "GO:0055074",
+        "label": "BiologicalProcess",
+        "name": "calcium ion homeostasis"
+      },
+      {
+        "id": "HP:0004363",
+        "label": "PhenotypicFeature",
+        "name": "Abnormal circulating calcium concentration"
+      },
+      {
+        "id": "MESH:D012080",
+        "label": "Disease",
+        "name": "Renal osteodystrophy"
+      }
+    ],
+    "reference": "https://en.wikipedia.org/wiki/Calcitriol#Mechanism_of_action https://pubmed.ncbi.nlm.nih.gov/23713873/ https://pubmed.ncbi.nlm.nih.gov/16970258/ https://go.drugbank.com/drugs/DB00136#description https://en.wikipedia.org/wiki/Renal_osteodystrophy#Pathogenesis"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Vitamin B6 deficiency",
+      "disease_mesh": "MESH:D026681",
+      "drug": "pyridoxine",
+      "drug_mesh": "MESH:D011736",
+      "drugbank": "DB:DB00165"
+    },
+    "links": [
+      {
+        "key": "interacts with",
+        "source": "MESH:D011736",
+        "target": "UniProt:O00764"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:O00764",
+        "target": "GO:0008478"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0008478",
+        "target": "CHEBI:18405"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "CHEBI:18405",
+        "target": "MESH:D026681"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D011736",
+        "label": "Drug",
+        "name": "pyridoxine"
+      },
+      {
+        "id": "UniProt:O00764",
+        "label": "Protein",
+        "name": "Pyridoxal kinase"
+      },
+      {
+        "id": "GO:0008478",
+        "label": "MolecularActivity",
+        "name": "pyridoxal kinase activity"
+      },
+      {
+        "id": "CHEBI:18405",
+        "label": "ChemicalSubstance",
+        "name": "pyridoxal 5'-phosphate"
+      },
+      {
+        "id": "MESH:D026681",
+        "label": "Disease",
+        "name": "Vitamin B6 deficiency"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00165#mechanism-of-action https://en.wikipedia.org/wiki/Pyridoxine"
+  },
+  {
+    "comments": "Setiptiline is considered a weak inhibitor of norepinephrine reuptake but I could not find evidence for this drug modulating the (nore)epinephrine uptake by Q7RTT9 or P23975. These putative mechanism has been observed in vitro/model organisms studies and is on Wikipedia (https://en.wikipedia.org/wiki/Setiptiline#Pharmacodynamics) but not on DrugBank or ChEMBL for example.",
+    "directed": true,
+    "graph": {
+      "disease": "Depressive disorder",
+      "disease_mesh": "MESH:D003866",
+      "drug": "setiptiline",
+      "drug_mesh": "MESH:C050605",
+      "drugbank": "DB:DB09304"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C050605",
+        "target": "UniProt:P08913"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C050605",
+        "target": "UniProt:P18089"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C050605",
+        "target": "UniProt:P18825"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P08913",
+        "target": "GO:0010700"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P18089",
+        "target": "GO:0010700"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P18825",
+        "target": "GO:0010700"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P08913",
+        "target": "GO:0032811"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P18089",
+        "target": "GO:0032811"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P18825",
+        "target": "GO:0032811"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0010700",
+        "target": "MESH:D003866"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0032811",
+        "target": "MESH:D003866"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C050605",
+        "label": "Drug",
+        "name": "setiptiline"
+      },
+      {
+        "id": "UniProt:P08913",
+        "label": "Protein",
+        "name": "Alpha-2A adrenergic receptor"
+      },
+      {
+        "id": "UniProt:P18089",
+        "label": "Protein",
+        "name": "Alpha-2B adrenergic receptor"
+      },
+      {
+        "id": "UniProt:P18825",
+        "label": "Protein",
+        "name": "Alpha-2C adrenergic receptor"
+      },
+      {
+        "id": "GO:0010700",
+        "label": "BiologicalProcess",
+        "name": "negative regulation of norepinephrine secretion"
+      },
+      {
+        "id": "GO:0032811",
+        "label": "BiologicalProcess",
+        "name": "negative regulation of epinephrine secretion"
+      },
+      {
+        "id": "MESH:D003866",
+        "label": "Disease",
+        "name": "Depressive disorder"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB09304#mechanism-of-action https://drugs.ncats.io/substance/7L38105Z6E#general"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Depressive disorder",
+      "disease_mesh": "MESH:D003866",
+      "drug": "setiptiline",
+      "drug_mesh": "MESH:C050605",
+      "drugbank": "DB:DB09304"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C050605",
+        "target": "MESH:D011985"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D011985",
+        "target": "GO:0001820"
+      },
+      {
+        "key": "precedes",
+        "source": "GO:0001820",
+        "target": "GO:0099153"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0099153",
+        "target": "MESH:D003866"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C050605",
+        "label": "Drug",
+        "name": "setiptiline"
+      },
+      {
+        "id": "MESH:D011985",
+        "label": "GeneFamily",
+        "name": "Receptors, Serotonin"
+      },
+      {
+        "id": "GO:0001820",
+        "label": "BiologicalProcess",
+        "name": "serotonin secretion"
+      },
+      {
+        "id": "GO:0099153",
+        "label": "BiologicalProcess",
+        "name": "synaptic transmission, serotonergic"
+      },
+      {
+        "id": "MESH:D003866",
+        "label": "Disease",
+        "name": "Depressive disorder"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB09304#mechanism-of-action https://drugs.ncats.io/substance/7L38105Z6E#general"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Open-angle glaucoma",
+      "disease_mesh": "MESH:D005902",
+      "drug": "carbachol",
+      "drug_mesh": "MESH:D002217",
+      "drugbank": "DB:DB00411"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D002217",
+        "target": "MESH:D011976"
+      },
+      {
+        "key": "participates in",
+        "source": "MESH:D011976",
+        "target": "REACT:R-HSA-390648"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "REACT:R-HSA-390648",
+        "target": "GO:0045987"
+      },
+      {
+        "key": "has phenotype",
+        "source": "GO:0045987",
+        "target": "HP:0000616"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "HP:0000616",
+        "target": "HP:0007906"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0007906",
+        "target": "MESH:D005902"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002217",
+        "label": "Drug",
+        "name": "carbachol"
+      },
+      {
+        "id": "MESH:D011976",
+        "label": "GeneFamily",
+        "name": "Receptors, Muscarinic"
+      },
+      {
+        "id": "REACT:R-HSA-390648",
+        "label": "Pathway",
+        "name": "Muscarinic acetylcholine receptors"
+      },
+      {
+        "id": "GO:0045987",
+        "label": "BiologicalProcess",
+        "name": "positive regulation of smooth muscle contraction"
+      },
+      {
+        "id": "HP:0000616",
+        "label": "PhenotypicFeature",
+        "name": "Miosis"
+      },
+      {
+        "id": "HP:0007906",
+        "label": "PhenotypicFeature",
+        "name": "Ocular Hypertension"
+      },
+      {
+        "id": "MESH:D005902",
+        "label": "Disease",
+        "name": "Open-angle glaucoma"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00411#mechanism-of-action https://pubchem.ncbi.nlm.nih.gov/compound/2551#section=Pharmacology-and-Biochemistry https://en.wikipedia.org/wiki/Carbachol#Chemistry_and_pharmacology https://www.kegg.jp/entry/D00524"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Open-angle glaucoma",
+      "disease_mesh": "MESH:D005902",
+      "drug": "carbachol",
+      "drug_mesh": "MESH:D002217",
+      "drugbank": "DB:DB00411"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D002217",
+        "target": "UniProt:Q15822"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q15822",
+        "target": "GO:0022848"
+      },
+      {
+        "key": "located in",
+        "source": "GO:0022848",
+        "target": "GO:0031594"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0031594",
+        "target": "HP:0000616"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "HP:0000616",
+        "target": "HP:0007906"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0007906",
+        "target": "MESH:D005902"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002217",
+        "label": "Drug",
+        "name": "carbachol"
+      },
+      {
+        "id": "UniProt:Q15822",
+        "label": "Protein",
+        "name": "Neuronal acetylcholine receptor subunit alpha-2"
+      },
+      {
+        "id": "GO:0022848",
+        "label": "MolecularActivity",
+        "name": "acetylcholine-gated cation-selective channel activity"
+      },
+      {
+        "id": "GO:0031594",
+        "label": "CellularComponent",
+        "name": "neuromuscular junction"
+      },
+      {
+        "id": "HP:0000616",
+        "label": "PhenotypicFeature",
+        "name": "Miosis"
+      },
+      {
+        "id": "HP:0007906",
+        "label": "PhenotypicFeature",
+        "name": "Ocular Hypertension"
+      },
+      {
+        "id": "MESH:D005902",
+        "label": "Disease",
+        "name": "Open-angle glaucoma"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00411#mechanism-of-action https://pubchem.ncbi.nlm.nih.gov/compound/2551#section=Pharmacology-and-Biochemistry https://en.wikipedia.org/wiki/Carbachol#Chemistry_and_pharmacology https://www.kegg.jp/entry/D00524"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Acne vulgaris",
+      "disease_mesh": "MESH:D000152",
+      "drug": "tazarotene",
+      "drug_mesh": "MESH:C086827",
+      "drugbank": "DB:DB00799"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P10276"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P28702"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P13631"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P10826"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "UniProt:P00533"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "UniProt:P00533"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "UniProt:P00533"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "UniProt:P00533"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "MESH:D053536"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "MESH:D053536"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "MESH:D053536"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "MESH:D053536"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "MESH:D053553"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "MESH:D053553"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "MESH:D053553"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "MESH:D053553"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "MESH:D020782"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "MESH:D020782"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "MESH:D020782"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "MESH:D020782"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "REACT:R-HSA-181438"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "REACT:R-HSA-181438"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "REACT:R-HSA-181438"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "REACT:R-HSA-181438"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "REACT:R-HSA-181438",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "UniProt:P00533",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D053536",
+        "target": "HP:0025249"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D053553",
+        "target": "HP:0025249"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0025249",
+        "target": "MESH:D000152"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006954",
+        "target": "MESH:D000152"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D020782",
+        "target": "MESH:D000152"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C086827",
+        "label": "Drug",
+        "name": "tazarotene"
+      },
+      {
+        "id": "UniProt:P10276",
+        "label": "Protein",
+        "name": "Retinoic acid receptor alpha"
+      },
+      {
+        "id": "UniProt:P10826",
+        "label": "Protein",
+        "name": "Retinoic acid receptor beta"
+      },
+      {
+        "id": "UniProt:P28702",
+        "label": "Protein",
+        "name": "Retinoic acid receptor RXR-beta"
+      },
+      {
+        "id": "UniProt:P13631",
+        "label": "Protein",
+        "name": "Retinoic acid receptor gamma"
+      },
+      {
+        "id": "MESH:D053536",
+        "label": "Protein",
+        "name": "Keratin-16"
+      },
+      {
+        "id": "MESH:D053553",
+        "label": "Protein",
+        "name": "Keratin-6"
+      },
+      {
+        "id": "MESH:D020782",
+        "label": "Protein",
+        "name": "Matrix Metalloproteinases"
+      },
+      {
+        "id": "UniProt:P00533",
+        "label": "Protein",
+        "name": "Epidermal growth factor receptor"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "HP:0025249",
+        "label": "PhenotypicFeature",
+        "name": "Comedo"
+      },
+      {
+        "id": "REACT:R-HSA-181438",
+        "label": "Pathway",
+        "name": "Toll Like Receptor 2 (TLR2) Cascade"
+      },
+      {
+        "id": "MESH:D000152",
+        "label": "Disease",
+        "name": "Acne vulgaris"
+      }
+    ],
+    "reference": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043801/#__sec2title https://go.drugbank.com/drugs/DB00799#mechanism-of-action https://pubmed.ncbi.nlm.nih.gov/28585191/ https://europepmc.org/article/med/32100454"
+  },
+  {
+    "comments": "MESH:D057705 refers to the movement of leukocytes (the term NCIT:C91439 would have been better suited here but could not be validated)",
+    "directed": true,
+    "graph": {
+      "disease": "Psoriasis",
+      "disease_mesh": "MESH:D011565",
+      "drug": "tazarotene",
+      "drug_mesh": "MESH:C086827",
+      "drugbank": "DB:DB00799"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P10276"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P28702"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P13631"
+      },
+      {
+        "key": "increases activity of",
+        "source": "MESH:C086827",
+        "target": "UniProt:P10826"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "GO:0043616"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "GO:0043616"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "GO:0043616"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "GO:0043616"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "MESH:D057705"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "MESH:D057705"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "MESH:D057705"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "MESH:D057705"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10276",
+        "target": "MESH:D003873"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P28702",
+        "target": "MESH:D003873"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P13631",
+        "target": "MESH:D003873"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "UniProt:P10826",
+        "target": "MESH:D003873"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D057705",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0043616",
+        "target": "MESH:D011565"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006954",
+        "target": "MESH:D011565"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D003873",
+        "target": "MESH:D011565"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C086827",
+        "label": "Drug",
+        "name": "tazarotene"
+      },
+      {
+        "id": "UniProt:P10276",
+        "label": "Protein",
+        "name": "Retinoic acid receptor alpha"
+      },
+      {
+        "id": "UniProt:P10826",
+        "label": "Protein",
+        "name": "Retinoic acid receptor beta"
+      },
+      {
+        "id": "UniProt:P28702",
+        "label": "Protein",
+        "name": "Retinoic acid receptor RXR-beta"
+      },
+      {
+        "id": "UniProt:P13631",
+        "label": "Protein",
+        "name": "Retinoic acid receptor gamma"
+      },
+      {
+        "id": "MESH:D003873",
+        "label": "PhenotypicFeature",
+        "name": "Dermatitis, Exfoliative"
+      },
+      {
+        "id": "GO:0043616",
+        "label": "BiologicalProcess",
+        "name": "keratinocyte proliferation"
+      },
+      {
+        "id": "MESH:D057705",
+        "label": "BiologicalProcess",
+        "name": "Transendothelial Migration Pathway"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "MESH:D011565",
+        "label": "Disease",
+        "name": "Psoriasis"
+      }
+    ],
+    "reference": "https://www.hindawi.com/journals/mi/2018/3067126/ https://go.drugbank.com/drugs/DB00799#mechanism-of-action"
+  },
+  {
+    "comments": "DrugBank has this drug modulating a human target/protein (https://go.drugbank.com/drugs/DB04930#mechanism-of-action) instead of the non-vertebrate proteome. Because humans (and other mammals) share similar ion channels this drug can have some toxic effects on the vertebrate host (e.g. https://pubmed.ncbi.nlm.nih.gov/11812616/)",
+    "directed": true,
+    "graph": {
+      "disease": "Infestation by Sarcoptes scabiei var hominis",
+      "disease_mesh": "MESH:D012532",
+      "drug": "permethrin",
+      "drug_mesh": "MESH:D026023",
+      "drugbank": "DB:DB04930"
+    },
+    "links": [
+      {
+        "key": "disrupts",
+        "source": "MESH:D026023",
+        "target": "UniProt:Q2VKV7"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q2VKV7",
+        "target": "GO:1902305"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:1902305",
+        "target": "GO:0086009"
+      },
+      {
+        "key": "occurs in",
+        "source": "GO:0086009",
+        "target": "MESH:D001369"
+      },
+      {
+        "key": "in taxon",
+        "source": "MESH:D001369",
+        "target": "NCBITaxon:52283"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:52283",
+        "target": "MESH:D012532"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D026023",
+        "label": "Drug",
+        "name": "permethrin"
+      },
+      {
+        "id": "UniProt:Q2VKV7",
+        "label": "Protein",
+        "name": "Sodium channel protein"
+      },
+      {
+        "id": "GO:1902305",
+        "label": "BiologicalProcess",
+        "name": "regulation of sodium ion transmembrane transport"
+      },
+      {
+        "id": "GO:0086009",
+        "label": "BiologicalProcess",
+        "name": "membrane repolarization"
+      },
+      {
+        "id": "MESH:D001369",
+        "label": "Cell",
+        "name": "Axons"
+      },
+      {
+        "id": "NCBITaxon:52283",
+        "label": "OrganismTaxon",
+        "name": "Sarcoptes scabiei"
+      },
+      {
+        "id": "MESH:D012532",
+        "label": "Disease",
+        "name": "Infestation by Sarcoptes scabiei var hominis"
+      }
+    ],
+    "reference": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1525/ https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4de55a80-67d6-42c0-a6fc-57b89400c5b3 https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2362985/ https://beta.targetvalidation.org/drug/CHEMBL1525 https://en.wikipedia.org/wiki/Permethrin#Pharmacokinetics https://en.wikipedia.org/wiki/Pyrethroid#Mode_of_action"
+  },
+  {
+    "comments": "this drug may bind to calmodulin therefore having an anti-neoplasmic effect (https://pubmed.ncbi.nlm.nih.gov/28062709/). For schizophrenia, the dopamine neurons are located in the mesolimbic dopaminergic system (BTO:0005591), which is a component pathway of the medial forebrain bundle (UBERON:0001910. See https://en.wikipedia.org/wiki/Medial_forebrain_bundle#Anatomy)",
+    "directed": true,
+    "graph": {
+      "disease": "Schizophrenia",
+      "disease_mesh": "MESH:D012559",
+      "drug": "perphenazine",
+      "drug_mesh": "MESH:D010546",
+      "drugbank": "DB:DB00850"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D010546",
+        "target": "UniProt:P14416"
+      },
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D010546",
+        "target": "UniProt:P21728"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P14416",
+        "target": "GO:0014046"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P21728",
+        "target": "GO:0014046"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "GO:0014046",
+        "target": "CHEBI:18243"
+      },
+      {
+        "key": "located in",
+        "source": "CHEBI:18243",
+        "target": "UBERON:0001910"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "UBERON:0001910",
+        "target": "MESH:D012559"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D010546",
+        "label": "Drug",
+        "name": "perphenazine"
+      },
+      {
+        "id": "UniProt:P14416",
+        "label": "Protein",
+        "name": "D(2) dopamine receptor"
+      },
+      {
+        "id": "UniProt:P21728",
+        "label": "Protein",
+        "name": "D(1A) dopamine receptor"
+      },
+      {
+        "id": "GO:0014046",
+        "label": "BiologicalProcess",
+        "name": "dopamine secretion"
+      },
+      {
+        "id": "CHEBI:18243",
+        "label": "ChemicalSubstance",
+        "name": "dopamine"
+      },
+      {
+        "id": "UBERON:0001910",
+        "label": "GrossAnatomicalStructure",
+        "name": "medial forebrain bundle"
+      },
+      {
+        "id": "MESH:D012559",
+        "label": "Disease",
+        "name": "Schizophrenia"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00850#mechanism-of-action https://en.wikipedia.org/wiki/Perphenazine https://en.wikipedia.org/wiki/Antipsychotic#Mechanism_of_action https://en.wikipedia.org/wiki/Mesolimbic_pathway#Relation_to_neurological_and_psychological_disorders"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Impotence",
+      "disease_mesh": "MESH:D007172",
+      "drug": "avanafil",
+      "drug_mesh": "MESH:C553414",
+      "drugbank": "DB:DB06237"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C553414",
+        "target": "UniProt:O76074"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "UniProt:O76074",
+        "target": "MESH:D006152"
+      },
+      {
+        "key": "causes",
+        "source": "MESH:D006152",
+        "target": "GO:0044557"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0044557",
+        "target": "GO:0008015"
+      },
+      {
+        "key": "located in",
+        "source": "GO:0008015",
+        "target": "UBERON:0004713"
+      },
+      {
+        "key": "participates in",
+        "source": "UBERON:0004713",
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+        "name": "Acute coronary syndrome"
+      }
+    ],
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+        "name": "synaptic remodeling"
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+        "name": "Bipolar disorder"
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+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00313#mechanismofaction"
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+        "target": "UniProt:O14975"
+      },
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+        "target": "REACT:R-HSA-2162123"
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+        "target": "MESH:D008881"
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+        "label": "Protein",
+        "name": "microsomal long-chain fatty acyl-CoA synthetase"
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+      {
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+        "label": "GrossAnatomicalStructure",
+        "name": "brain"
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+      {
+        "id": "MESH:C026563",
+        "label": "ChemicalSubstance",
+        "name": "Arachidonoyl-CoA"
+      },
+      {
+        "id": "REACT:R-HSA-2162123",
+        "label": "Pathway",
+        "name": "inflammatory prostaglandins production"
+      },
+      {
+        "id": "MESH:D008881",
+        "label": "Disease",
+        "name": "migraine"
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+    ],
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+        "target": "UniProt:P30559"
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+      },
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+        "target": "MESH:D006473"
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+    ],
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+        "label": "Drug",
+        "name": "Carbetocin"
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+      {
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+        "label": "Protein",
+        "name": "oxytocin receptors"
+      },
+      {
+        "id": "GO:0070474",
+        "label": "BiologicalProcess",
+        "name": "uterine smooth muscle relaxation"
+      },
+      {
+        "id": "MESH:D006473",
+        "label": "Disease",
+        "name": "postpartum hemorrhage"
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+    ],
+    "reference": "https://go.drugbank.com/drugs/DB01282#mechanismofaction"
+  },
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+      "drug": "cabergoline",
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+        "name": "Cabergoline"
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+        "label": "Protein",
+        "name": "D2 dopamine receptor"
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+        "name": "Adenylate cyclase-inhibiting dopamine receptor signaling pathway"
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+      {
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+        "name": "Positive regulation of\u00a0prolactin\u00a0secretion"
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+        "name": "Hyperprolactinemia"
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       },
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-        "label": "Protein",
-        "name": "H1 histamine receptor"
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+        "name": "Noradrenaline"
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       {
-        "id": "MESH:D006255",
+        "id": "GO:0061533",
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+        "name": "Norepinephrine secretion, neurotransmission"
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         "label": "Disease",
-        "name": "Seasonal allergic rhinitis"
+        "name": "Attention deficit hyperactivity disorder"
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+    "reference": "https://go.drugbank.com/drugs/DB00289 https://pubmed.ncbi.nlm.nih.gov/24259638/"
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     "graph": {
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-      "drug": "brompheniramine",
-      "drug_mesh": "MESH:D001977",
-      "drugbank": "DB:DB00835"
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       },
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       }
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-        "target": "CL:0000198"
-      },
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+        "name": "Anxiety"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00842"
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+    },
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       {
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       },
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       },
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     ],
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     "directed": true,
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+      },
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+        "id": "MESH:D001196",
         "label": "Disease",
-        "name": "Constipation"
+        "name": "Ascariasis"
       }
     ],
-    "reference": "https://go.drugbank.com/drugs/DB02659 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015201/"
+    "reference": "https://go.drugbank.com/drugs/DB00848#BE0003585"
   },
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+    "comment": "Withdrawn",
     "directed": true,
     "graph": {
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-      "disease_mesh": "MESH:D019294",
-      "drug": "cholic acid",
-      "drug_mesh": "MESH:D019826",
-      "drugbank": "DB:DB02659"
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-        "label": "ChemicalSubstance",
-        "name": "Cholestanol"
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-        "id": "MESH:D011453",
-        "label": "ChemicalSubstance",
-        "name": "Prostaglandins"
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+        "name": "Prostaglandin Synthesis"
       },
       {
         "id": "GO:0006954",
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-        "name": "inflammatory response"
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+        "name": "Skin itching"
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-        "name": "Acute pain"
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-        "name": "response to acetylcholine"
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-        "name": "smooth muscle contraction"
-      },
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-        "label": "GrossAnatomicalStructure",
-        "name": "bronchus"
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-        "name": "Substance P"
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-        "id": "MESH:D020078",
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-        "name": "Neurogenic Inflammation"
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+        "name": "Inflammation"
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       },
       {
-        "id": "UBERON:0010061",
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-        "name": "nasopharynx cavity"
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       },
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-        "id": "MESH:D006255",
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         "label": "Disease",
-        "name": "Seasonal allergic rhinitis"
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-      "drug_mesh": "MESH:C582203",
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-        "target": "GO:0070509"
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       },
       {
         "key": "participates in",
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-        "target": "GO:0070509"
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       },
       {
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-      },
-      {
-        "key": "contributes to",
-        "source": "GO:0070509",
-        "target": "GO:0045907"
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       },
       {
         "key": "positively regulates",
-        "source": "GO:0045907",
-        "target": "GO:0008217"
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       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0008217",
-        "target": "MESH:D006973"
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       }
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     "nodes": [
       {
-        "id": "MESH:D020748",
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-        "name": "mibefradil"
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-      },
-      {
-        "id": "UniProt:Q13936",
-        "label": "Protein",
-        "name": "Voltage-dependent L-type calcium channel subunit alpha-1C"
+        "name": "Scopolamine"
       },
       {
-        "id": "UniProt:O95180",
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       },
       {
-        "id": "UniProt:Q01668",
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       },
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       },
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         "label": "Protein",
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       },
       {
-        "id": "GO:0070509",
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-        "name": "transmembrane calcium influx"
-      },
-      {
-        "id": "GO:0045907",
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-        "name": "positive regulation of vasoconstriction"
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       },
       {
-        "id": "GO:0008217",
-        "label": "BiologicalProcess",
-        "name": "Blood Pressure"
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       },
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-        "id": "MESH:D006973",
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-        "name": "Hypertension"
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-    "comment": "Mibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs",
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-      "drugbank": "DB:DB01388"
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       },
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       },
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       },
       {
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       },
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       },
       {
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       },
       {
         "key": "participates in",
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-        "target": "GO:0070509"
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       },
       {
-        "key": "contributes to",
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-        "target": "GO:0045907"
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       },
       {
-        "key": "negatively regulates",
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       },
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-        "target": "MESH:D000787"
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-        "label": "Protein",
-        "name": "Voltage-dependent T-type calcium channel subunit alpha-1G"
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       },
       {
-        "id": "UniProt:Q13936",
-        "label": "Protein",
-        "name": "Voltage-dependent L-type calcium channel subunit alpha-1C"
-      },
-      {
-        "id": "UniProt:O95180",
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         "label": "Protein",
-        "name": "Voltage-dependent T-type calcium channel subunit alpha-1H"
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       },
       {
-        "id": "UniProt:Q01668",
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       },
       {
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         "label": "Protein",
-        "name": "Voltage-dependent L-type calcium channel subunit alpha-1F"
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       },
       {
-        "id": "UniProt:Q9P0X4",
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         "label": "Protein",
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       },
       {
-        "id": "UniProt:Q13698",
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         "label": "Protein",
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       {
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-        "id": "GO:0045907",
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-        "name": "positive regulation of vasoconstriction"
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+        "name": "Gland of nasal mucosa"
       },
       {
-        "id": "GO:0008015",
-        "label": "BiologicalProcess",
-        "name": "blood circulation"
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+        "label": "GrossAnatomicalStructure",
+        "name": "Nasal mucus"
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       {
-        "id": "MESH:D000787",
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         "label": "Disease",
-        "name": "Angina pectoris"
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       }
     ],
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   },
   {
-    "comment": "Mechanism of action of diloxanide is unknown",
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     "graph": {
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-      "drug": "diloxanide furoate",
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-      "drugbank": "DB:DB08792"
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-        "target": "MESH:D000562"
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-        "name": "diloxanide furoate"
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       },
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       },
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       },
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       },
       {
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-        "target": "MESH:D046152"
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+      },
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     "nodes": [
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+        "name": "Scopolamine"
       },
       {
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+        "id": "UniProt:P11229",
         "label": "Protein",
-        "name": "Mast/stem cell growth factor receptor Kit"
+        "name": "Muscarinic acetylcholine receptor M1"
       },
       {
-        "id": "UniProt:P16234",
+        "id": "UniProt:P08172",
         "label": "Protein",
-        "name": "Platelet-derived growth factor receptor alpha"
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       },
       {
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-        "name": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants"
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       {
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       },
       {
-        "id": "GO:0008284",
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-        "name": "positive regulation of cell population proliferation"
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       {
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   },
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     "graph": {
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-      "drugbank": "DB:DB08896"
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       },
       {
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       {
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-        "target": "MESH:D006528"
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+        "label": "Protein",
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+        "name": "Muscarinic acetylcholine receptor M5"
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+        "label": "BiologicalProcess",
+        "name": "Response to acetylcholine"
+      },
+      {
+        "id": "MESH:D016084",
+        "label": "Disease",
+        "name": "Bronchoconstriction"
+      },
+      {
+        "id": "MESH:D001249",
+        "label": "Disease",
+        "name": "Asthma"
+      },
+      {
+        "id": "MESH:D003371",
+        "label": "Disease",
+        "name": "Cough"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00747 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785753/"
+  },
+  {
+    "directed": true,
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+    },
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+      },
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       },
       {
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-        "target": "MESH:D006528"
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     ],
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     "nodes": [
       {
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-        "label": "Disease",
-        "name": "regorafenib"
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+        "name": "Scopolamine"
       },
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         "label": "Protein",
-        "name": "RAF proto-oncogene serine/threonine-protein kinase"
+        "name": "Muscarinic acetylcholine receptor M3"
       },
       {
-        "id": "UniProt:P15056",
-        "label": "Protein",
-        "name": "Serine/threonine-protein kinase B-raf"
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+        "label": "BiologicalProcess",
+        "name": "Acetylcholine-induced gastric acid secretion"
       },
       {
-        "id": "UniProt:P16234",
-        "label": "Protein",
-        "name": "Platelet-derived growth factor receptor alpha"
+        "id": "MESH:D005744",
+        "label": "ChemicalSubstance",
+        "name": "Gastric Acid"
       },
       {
-        "id": "UniProt:P11362",
-        "label": "Protein",
-        "name": "Fibroblast growth factor receptor 1"
-      },
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+        "label": "Disease",
+        "name": "Peptic ulcer"
+      }
+    ],
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-        "label": "Protein",
-        "name": "Vascular endothelial growth factor receptor 1"
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       },
       {
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-        "label": "Protein",
-        "name": "Vascular endothelial growth factor receptor 2"
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       },
       {
-        "id": "REACT:R-HSA-9006934",
-        "label": "Pathway",
-        "name": "Signaling by Receptor Tyrosine Kinases"
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+    ],
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-        "name": "positive regulation of cell population proliferation"
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       },
       {
-        "id": "GO:0045766",
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-        "name": "positive regulation of angiogenesis"
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       {
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         "label": "Disease",
-        "name": "Hepatocellular Carcinoma"
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       }
     ],
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     "directed": true,
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-      "drug": "selexipag",
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       },
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       },
       {
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       },
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       },
       {
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-        "name": "prostacyclin receptor"
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       },
       {
-        "id": "GO:0016501",
-        "label": "MolecularActivity",
-        "name": "prostacyclin receptor activity"
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       },
       {
-        "id": "GO:0042311",
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-        "name": "vasodilation"
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       },
       {
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-        "label": "BiologicalProcess",
-        "name": "blood pressure"
+        "id": "NCBITaxon:100816",
+        "label": "OrganismTaxon",
+        "name": "Madurella mycetomatis"
       },
       {
-        "id": "MESH:D000081029",
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         "label": "Disease",
-        "name": "Pulmonary arterial hypertension"
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       }
     ],
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     "directed": true,
     "graph": {
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-      "disease_mesh": "MESH:D017192",
-      "drug": "delafloxacin",
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-      "drugbank": "DB:DB11943"
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       },
       {
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-        "target": "MESH:D017192"
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-        "name": "DNA topoisomerase 4 subunit A (Staphylococcus aureus)"
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       },
       {
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-        "name": "DNA gyrase subunit A (Staphylococcus aureus)"
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-        "name": "bacterial-type DNA replication"
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       {
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       {
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-        "name": "Bacterial Skin Diseases"
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       },
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       {
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         "label": "Protein",
-        "name": "Histamine H1 receptor"
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       },
       {
-        "id": "GO:0004969",
-        "label": "MolecularActivity",
-        "name": "histamine receptor activity"
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       },
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-        "name": "cellular response to histamine"
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-        "name": "inflammatory response"
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     ],
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-        "target": "GO:0008283"
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       },
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       {
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-        "source": "GO:0001696",
-        "target": "MESH:D010437"
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       },
       {
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-        "label": "Protein",
-        "name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]"
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-        "label": "MolecularActivity",
-        "name": "oxidoreductase activity"
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-        "label": "ChemicalSubstance",
-        "name": "Prostaglandins"
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+        "name": "Lanosterol 14-alpha demethylase"
       },
       {
-        "id": "GO:0070254",
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-        "name": "mucus secretion"
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       },
       {
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-        "name": "gastric acid secretion"
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       },
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-        "id": "MESH:D010437",
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         "label": "Disease",
-        "name": "Peptic ulcer"
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-        "target": "MESH:D011471"
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D003093"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB05812",
+        "id": "MESH:D000069285",
         "label": "Drug",
-        "name": "abiraterone acetate"
+        "name": "Infliximab"
       },
       {
-        "id": "UniProt:P15538",
+        "id": "UniProt:P01375",
         "label": "Protein",
-        "name": "Cytochrome P450 11B1, mitochondrial"
+        "name": "Tumor necrosis factor"
       },
       {
-        "id": "UniProt:P08686",
-        "label": "Protein",
-        "name": "Steroid 21-hydroxylase"
+        "id": "REACT:R-HSA-75893",
+        "label": "Pathway",
+        "name": "TNF signaling"
       },
       {
-        "id": "UniProt:P05177",
-        "label": "Protein",
-        "name": "Cytochrome P450 1A2"
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "Inflammation"
       },
       {
-        "id": "UniProt:P11712",
-        "label": "Protein",
-        "name": "Cytochrome P450 2C9"
+        "id": "MESH:D003093",
+        "label": "Disease",
+        "name": "Ulcerative colitis"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00065#BE0000704"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Crohn's disease",
+      "disease_mesh": "MESH:D003424",
+      "drug": "infliximab",
+      "drug_mesh": "MESH:D000069285",
+      "drugbank": "DB:DB00065"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D000069285",
+        "target": "UniProt:P01375"
       },
       {
-        "id": "UniProt:P08684",
-        "label": "Protein",
-        "name": "Cytochrome P450 3A4"
+        "key": "positively regulates",
+        "source": "UniProt:P01375",
+        "target": "REACT:R-HSA-75893"
       },
       {
-        "id": "GO:0006704",
-        "label": "BiologicalProcess",
-        "name": "glucocorticoid biosynthetic process"
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-75893",
+        "target": "GO:0006954"
       },
       {
-        "id": "GO:0061370",
-        "label": "BiologicalProcess",
-        "name": "testosterone biosynthetic process"
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D003424"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D000069285",
+        "label": "Drug",
+        "name": "Infliximab"
       },
       {
-        "id": "HP:0030088",
-        "label": "PhenotypicFeature",
-        "name": "Increased serum testosterone level"
+        "id": "UniProt:P01375",
+        "label": "Protein",
+        "name": "Tumor necrosis factor"
       },
       {
-        "id": "MESH:D011471",
+        "id": "REACT:R-HSA-75893",
+        "label": "Pathway",
+        "name": "TNF signaling"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "Inflammation"
+      },
+      {
+        "id": "MESH:D003424",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Crohn's disease"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+    "reference": "https://go.drugbank.com/drugs/DB00065#BE0000704"
   },
   {
-    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also acts as a partial antagonist of the androgen receptor (UniProt:P10275)",
     "directed": true,
     "graph": {
-      "disease": "Malignant tumor of prostate",
-      "disease_mesh": "MESH:D011471",
-      "drug": "abiraterone acetate",
-      "drug_mesh": "MESH:D000069501,MESH:C089740",
-      "drugbank": "DB:DB05812"
+      "disease": "Ankylosing spondylitis",
+      "disease_mesh": "MESH:D013167",
+      "drug": "infliximab",
+      "drug_mesh": "MESH:D000069285",
+      "drugbank": "DB:DB00065"
     },
     "links": [
       {
         "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P10275"
+        "source": "MESH:D000069285",
+        "target": "UniProt:P01375"
       },
       {
         "key": "positively regulates",
-        "source": "UniProt:P10275",
-        "target": "GO:0060769"
+        "source": "UniProt:P01375",
+        "target": "REACT:R-HSA-75893"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0060769",
-        "target": "MESH:D011471"
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-75893",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D013167"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB05812",
+        "id": "MESH:D000069285",
         "label": "Drug",
-        "name": "abiraterone acetate"
+        "name": "Infliximab"
       },
       {
-        "id": "UniProt:P10275",
+        "id": "UniProt:P01375",
         "label": "Protein",
-        "name": "Androgen receptor"
+        "name": "Tumor necrosis factor"
       },
       {
-        "id": "GO:0060769",
+        "id": "REACT:R-HSA-75893",
+        "label": "Pathway",
+        "name": "TNF signaling"
+      },
+      {
+        "id": "GO:0006954",
         "label": "BiologicalProcess",
-        "name": "positive regulation of epithelial cell proliferation involved in prostate gland development"
+        "name": "Inflammation"
       },
       {
-        "id": "MESH:D011471",
+        "id": "MESH:D013167",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Ankylosing spondylitis"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/Androgen_receptor#Mechanism_of_action https://en.wikipedia.org/wiki/Androgen_deprivation_therapy#Methods_based_on_drugs https://www.kegg.jp/entry/D09701"
+    "reference": "https://go.drugbank.com/drugs/DB00065#BE0000704"
   },
   {
-    "comments": "DrugBank has this drug as a beta 1 antagonist but data elsewhere does not seem to support the anatagonism role (e.g. https://www.drugs.com/pro/terbutaline.html#s-34090-1, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1760 https://www.genome.jp/dbget-bin/www_bget?cpd:C07129)",
     "directed": true,
     "graph": {
-      "disease": "Tear film insufficiency",
-      "disease_mesh": "MESH:D015352",
-      "drug": "terbutaline",
-      "drug_mesh": "MESH:D013726",
-      "drugbank": "DB:DB00871"
+      "disease": "Psoriatic Arthritis",
+      "disease_mesh": "MESH:D015535",
+      "drug": "infliximab",
+      "drug_mesh": "MESH:D000069285",
+      "drugbank": "DB:DB00065"
     },
     "links": [
       {
-        "key": "positively regulates",
-        "source": "MESH:D013726",
-        "target": "UniProt:P13945"
+        "key": "decreases activity of",
+        "source": "MESH:D000069285",
+        "target": "UniProt:P01375"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D013726",
-        "target": "UniProt:P07550"
-      },
-      {
-        "key": "positively correlated with",
-        "source": "UniProt:P13945",
-        "target": "GO:0050728"
+        "source": "UniProt:P01375",
+        "target": "REACT:R-HSA-75893"
       },
       {
-        "key": "positively correlated with",
-        "source": "UniProt:P07550",
-        "target": "GO:0050728"
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-75893",
+        "target": "GO:0006954"
       },
       {
-        "key": "negatively correlated with",
-        "source": "GO:0050728",
-        "target": "MESH:D015352"
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D015535"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "MESH:D013726",
+        "id": "MESH:D000069285",
         "label": "Drug",
-        "name": "terbutaline"
+        "name": "Infliximab"
       },
       {
-        "id": "UniProt:P13945",
+        "id": "UniProt:P01375",
         "label": "Protein",
-        "name": "Beta-3 adrenergic receptor"
+        "name": "Tumor necrosis factor"
       },
       {
-        "id": "UniProt:P07550",
-        "label": "Protein",
-        "name": "Beta-2 adrenergic receptor"
+        "id": "REACT:R-HSA-75893",
+        "label": "Pathway",
+        "name": "TNF signaling"
       },
       {
-        "id": "GO:0050728",
+        "id": "GO:0006954",
         "label": "BiologicalProcess",
-        "name": "negative regulation of inflammatory response"
+        "name": "Inflammation"
       },
       {
-        "id": "MESH:D015352",
+        "id": "MESH:D015535",
         "label": "Disease",
-        "name": "Tear film insufficiency"
+        "name": "Psoriatic Arthritis"
       }
     ],
-    "reference": "https://go.drugbank.com/drugs/DB00871#mechanism-of-action https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345890/ https://europepmc.org/article/MED/23360156"
+    "reference": "https://go.drugbank.com/drugs/DB00065#BE0000704"
   },
   {
+    "comment": "Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action",
     "directed": true,
     "graph": {
-      "disease": "Malignant tumor of prostate",
-      "disease_mesh": "MESH:D011471",
-      "drug": "abiraterone acetate",
-      "drug_mesh": "MESH:D000069501,MESH:C089740",
-      "drugbank": "DB:DB05812"
+      "disease": "Spasticity",
+      "disease_mesh": "MESH:D009128",
+      "drug": "methocarbamol",
+      "drug_mesh": "MESH:D008721",
+      "drugbank": "DB:DB00423"
     },
     "links": [
       {
-        "key": "derives into",
-        "source": "DB:DB05812",
-        "target": "MESH:C000600172"
-      },
-      {
-        "key": "negatively regulates",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P05093"
-      },
-      {
-        "key": "negatively regulates",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P26439"
-      },
-      {
-        "key": "negatively regulates",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P14060"
+        "key": "causes",
+        "source": "MESH:D008721",
+        "target": "GO:0090075"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P05093",
-        "target": "GO:0006702"
-      },
+        "key": "negatively correlated with",
+        "source": "GO:0090075",
+        "target": "MESH:D009128"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
       {
-        "key": "positively regulates",
-        "source": "UniProt:P26439",
-        "target": "GO:0006702"
+        "id": "MESH:D008721",
+        "label": "Drug",
+        "name": "Methacarbamol"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P14060",
-        "target": "GO:0006702"
+        "id": "GO:0090075",
+        "label": "BiologicalProcess",
+        "name": "Relaxation of muscle"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P05093",
-        "target": "GO:0006704"
-      },
+        "id": "MESH:D009128",
+        "label": "Disease",
+        "name": "Spasticity"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00423"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Urge Incontinence",
+      "disease_mesh": "MESH:D053202",
+      "drug": "Darifenacin",
+      "drug_mesh": "MESH:C101207",
+      "drugbank": "DB:DB00496"
+    },
+    "links": [
       {
-        "key": "positively regulates",
-        "source": "UniProt:P26439",
-        "target": "GO:0006704"
+        "key": "decreases activity of",
+        "source": "MESH:C101207",
+        "target": "UniProt:P20309"
       },
       {
         "key": "positively regulates",
-        "source": "UniProt:P14060",
-        "target": "GO:0006704"
-      },
-      {
-        "key": "positively correlated with",
-        "source": "GO:0006704",
-        "target": "HP:0030088"
+        "source": "UniProt:P20309",
+        "target": "GO:0014832"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0006702",
-        "target": "HP:0030088"
+        "key": "positively regulates",
+        "source": "GO:0014832",
+        "target": "GO:0060073"
       },
       {
         "key": "positively correlated with",
-        "source": "HP:0030088",
-        "target": "MESH:D011471"
+        "source": "GO:0060073",
+        "target": "MESH:D053202"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB05812",
-        "label": "Drug",
-        "name": "abiraterone acetate"
-      },
-      {
-        "id": "MESH:C000600172",
+        "id": "MESH:C101207",
         "label": "Drug",
-        "name": "delta4-abiraterone"
-      },
-      {
-        "id": "UniProt:P05093",
-        "label": "Protein",
-        "name": "Steroid 17-alpha-hydroxylase/17,20 lyase"
-      },
-      {
-        "id": "UniProt:P26439",
-        "label": "Protein",
-        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2"
+        "name": "Darifenacin"
       },
       {
-        "id": "UniProt:P14060",
+        "id": "UniProt:P20309",
         "label": "Protein",
-        "name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1"
+        "name": "Muscarinic acetylcholine receptor M3"
       },
       {
-        "id": "GO:0006702",
+        "id": "GO:0014832",
         "label": "BiologicalProcess",
-        "name": "androgen biosynthetic process"
+        "name": "Urinary bladder smooth muscle contraction"
       },
       {
-        "id": "GO:0006704",
+        "id": "GO:0060073",
         "label": "BiologicalProcess",
-        "name": "glucocorticoid biosynthetic process"
+        "name": "Urination"
       },
       {
-        "id": "HP:0030088",
-        "label": "PhenotypicFeature",
-        "name": "Increased serum testosterone level"
-      },
-      {
-        "id": "MESH:D011471",
+        "id": "MESH:D053202",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Urge Incontinence"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/%CE%944-Abiraterone https://www.nature.com/articles/nrurol.2016.101 https://www.medchemexpress.com/D4-abiraterone.html"
+    "reference": "https://go.drugbank.com/drugs/DB00496 https://en.wikipedia.org/wiki/Urinary_incontinence"
   },
   {
     "directed": true,
     "graph": {
-      "disease": "Malignant tumor of prostate",
-      "disease_mesh": "MESH:D011471",
-      "drug": "abiraterone acetate",
-      "drug_mesh": "MESH:D000069501,MESH:C089740",
-      "drugbank": "DB:DB05812"
+      "disease": "Primary cutaneous T-cell lymphoma",
+      "disease_mesh": "MESH:D016410",
+      "drug": "Desoximetasone",
+      "drug_mesh": "MESH:D003899",
+      "drugbank": "DB:DB00547"
     },
     "links": [
       {
-        "key": "derives into",
-        "source": "DB:DB05812",
-        "target": "MESH:C000600172"
-      },
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-        "key": "decreases activity of",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P18405"
-      },
-      {
-        "key": "decreases activity of",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P31213"
-      },
-      {
-        "key": "decreases activity of",
-        "source": "MESH:C000600172",
-        "target": "UniProt:Q9H8P0"
+        "key": "increases activity of",
+        "source": "MESH:D003899",
+        "target": "UniProt:P04150"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P18405",
-        "target": "GO:0033764"
+        "key": "increases abundance of",
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+        "target": "UniProt:P04083"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P31213",
-        "target": "GO:0033764"
+        "key": "negatively regulates",
+        "source": "UniProt:P04083",
+        "target": "REACT:R-HSA-2162123"
       },
       {
         "key": "positively regulates",
-        "source": "UniProt:Q9H8P0",
-        "target": "GO:0033764"
-      },
-      {
-        "key": "produces",
-        "source": "GO:0033764",
-        "target": "CHEBI:16330"
+        "source": "REACT:R-HSA-2162123",
+        "target": "GO:0006954"
       },
       {
-        "key": "positively correlated with",
-        "source": "CHEBI:16330",
-        "target": "MESH:D011471"
+        "key": "occurs in",
+        "source": "GO:0006954",
+        "target": "MESH:D016410"
       }
     ],
     "multigraph": true,
     "nodes": [
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-        "id": "DB:DB05812",
-        "label": "Drug",
-        "name": "abiraterone acetate"
-      },
-      {
-        "id": "MESH:C000600172",
+        "id": "MESH:D003899",
         "label": "Drug",
-        "name": "delta4-abiraterone"
-      },
-      {
-        "id": "UniProt:P18405",
-        "label": "Protein",
-        "name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1"
+        "name": "Desoximetasone"
       },
       {
-        "id": "UniProt:P31213",
+        "id": "UniProt:P04150",
         "label": "Protein",
-        "name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2"
+        "name": "Glucocorticoid receptor"
       },
       {
-        "id": "UniProt:Q9H8P0",
+        "id": "UniProt:P04083",
         "label": "Protein",
-        "name": "Polyprenol reductase"
+        "name": "Annexin A1"
       },
       {
-        "id": "GO:0033764",
-        "label": "MolecularActivity",
-        "name": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
+        "id": "REACT:R-HSA-2162123",
+        "label": "Pathway",
+        "name": "Prostaglandin Synthesis"
       },
       {
-        "id": "CHEBI:16330",
-        "label": "ChemicalSubstance",
-        "name": "17\u03b2-hydroxy-5\u03b1-androstan-3-one"
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "Inflammation"
       },
       {
-        "id": "MESH:D011471",
+        "id": "MESH:D016410",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Primary cutaneous T-cell lymphoma"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/%CE%944-Abiraterone https://www.nature.com/articles/nrurol.2016.101 https://www.medchemexpress.com/D4-abiraterone.html https://en.wikipedia.org/wiki/Dihydrotestosterone#Biological_function https://en.wikipedia.org/wiki/5%CE%B1-Reductase"
+    "reference": "https://go.drugbank.com/drugs/DB00547#BE0000794 https://en.wikipedia.org/wiki/Cutaneous_T_cell_lymphoma"
   },
   {
     "directed": true,
     "graph": {
-      "disease": "Allergic rhinitis",
-      "disease_mesh": "MESH:D065631",
-      "drug": "mizolastine",
-      "drug_mesh": "MESH:C076170",
-      "drugbank": "DB:DB12523"
+      "disease": "Granuloma annulare",
+      "disease_mesh": "MESH:D016460",
+      "drug": "Desoximetasone",
+      "drug_mesh": "MESH:D003899",
+      "drugbank": "DB:DB00547"
     },
     "links": [
       {
-        "key": "decreases activity of",
-        "source": "MESH:C076170",
-        "target": "UniProt:P35367"
+        "key": "increases activity of",
+        "source": "MESH:D003899",
+        "target": "UniProt:P04150"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P35367",
-        "target": "GO:0004969"
+        "key": "increases abundance of",
+        "source": "UniProt:P04150",
+        "target": "UniProt:P04083"
       },
       {
-        "key": "participates in",
-        "source": "GO:0004969",
-        "target": "GO:0071420"
+        "key": "negatively regulates",
+        "source": "UniProt:P04083",
+        "target": "REACT:R-HSA-2162123"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0071420",
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-        "target": "GO:0008203"
+        "id": "UniProt:P04083",
+        "label": "Protein",
+        "name": "Annexin A1"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P05177",
-        "target": "GO:0008203"
+        "id": "REACT:R-HSA-2162123",
+        "label": "Pathway",
+        "name": "Prostaglandin Synthesis"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P11712",
-        "target": "GO:0008203"
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "Inflammation"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P08684",
-        "target": "GO:0008203"
+        "id": "MESH:D005076",
+        "label": "Disease",
+        "name": "Exanthem"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00547#BE0000794 https://en.wikipedia.org/wiki/Exanthem"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Seborrheic dermatitis",
+      "disease_mesh": "MESH:D012628",
+      "drug": "desoximetasone",
+      "drug_mesh": "MESH:D003899",
+      "drugbank": "DB:DB00547"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:D003899",
+        "target": "UniProt:P04150"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0008203",
-        "target": "GO:0061370"
+        "key": "increases abundance of",
+        "source": "UniProt:P04150",
+        "target": "UniProt:P04083"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0061370",
-        "target": "HP:0030088"
+        "key": "negatively regulates",
+        "source": "UniProt:P04083",
+        "target": "REACT:R-HSA-2162123"
       },
       {
-        "key": "positively correlated with",
-        "source": "HP:0030088",
-        "target": "MESH:D011471"
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-2162123",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "causes",
+        "source": "GO:0006954",
+        "target": "MESH:D012628"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB05812",
+        "id": "MESH:D003899",
         "label": "Drug",
-        "name": "abiraterone acetate"
-      },
-      {
-        "id": "UniProt:P15538",
-        "label": "Protein",
-        "name": "Cytochrome P450 11B1, mitochondrial"
+        "name": "Desoximetasone"
       },
       {
-        "id": "UniProt:P08686",
-        "label": "Protein",
-        "name": "Steroid 21-hydroxylase"
-      },
-      {
-        "id": "UniProt:P05177",
-        "label": "Protein",
-        "name": "Cytochrome P450 1A2"
-      },
-      {
-        "id": "UniProt:P11712",
+        "id": "UniProt:P04150",
         "label": "Protein",
-        "name": "Cytochrome P450 2C9"
+        "name": "Glucocorticoid receptor"
       },
       {
-        "id": "UniProt:P08684",
+        "id": "UniProt:P04083",
         "label": "Protein",
-        "name": "Cytochrome P450 3A4"
+        "name": "Annexin A1"
       },
       {
-        "id": "GO:0008203",
-        "label": "BiologicalProcess",
-        "name": "cholesterol metabolic process"
+        "id": "REACT:R-HSA-2162123",
+        "label": "Pathway",
+        "name": "Prostaglandin Synthesis"
       },
       {
-        "id": "GO:0061370",
+        "id": "GO:0006954",
         "label": "BiologicalProcess",
-        "name": "testosterone biosynthetic process"
-      },
-      {
-        "id": "HP:0030088",
-        "label": "PhenotypicFeature",
-        "name": "Increased serum testosterone level"
+        "name": "Inflammation"
       },
       {
-        "id": "MESH:D011471",
+        "id": "MESH:D012628",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Seborrheic dermatitis"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+    "reference": "https://go.drugbank.com/drugs/DB00547#BE0000794 https://en.wikipedia.org/wiki/Seborrhoeic_dermatitis"
   },
   {
-    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also inhibits all these cytochrome P450s and can be useful in treating castration-resistant prostate cancers.",
     "directed": true,
     "graph": {
-      "disease": "Malignant tumor of prostate",
-      "disease_mesh": "MESH:D011471",
-      "drug": "abiraterone acetate",
-      "drug_mesh": "MESH:D000069501,MESH:C089740",
-      "drugbank": "DB:DB05812"
+      "disease": "Migraine",
+      "disease_mesh": "MESH:D008881",
+      "drug": "almotriptan",
+      "drug_mesh": "MESH:C409045",
+      "drugbank": "DB:DB00918"
     },
     "links": [
       {
-        "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P15538"
-      },
-      {
-        "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P08686"
+        "key": "increases activity of",
+        "source": "MESH:C409045",
+        "target": "UniProt:P28222"
       },
       {
-        "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P05177"
+        "key": "increases activity of",
+        "source": "MESH:C409045",
+        "target": "UniProt:P28221"
       },
       {
-        "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P11712"
+        "key": "positively regulates",
+        "source": "UniProt:P28222",
+        "target": "GO:0042310"
       },
       {
-        "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P08684"
+        "key": "negatively regulates",
+        "source": "GO:0042310",
+        "target": "MESH:D010146"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P15538",
-        "target": "GO:0006704"
+        "key": "positively correlated with",
+        "source": "MESH:D010146",
+        "target": "MESH:D008881"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P08686",
-        "target": "GO:0006704"
+        "key": "negatively regulates",
+        "source": "UniProt:P28222",
+        "target": "MESH:D020078"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P05177",
-        "target": "GO:0006704"
+        "key": "negatively regulates",
+        "source": "UniProt:P28221",
+        "target": "MESH:D020078"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P11712",
-        "target": "GO:0006704"
+        "key": "positively correlated with",
+        "source": "MESH:D020078",
+        "target": "MESH:D008881"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P08684",
-        "target": "GO:0006704"
+        "key": "decreases activity of",
+        "source": "UniProt:P28222",
+        "target": "UBERON:0001645"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0006704",
-        "target": "GO:0061370"
+        "key": "decreases activity of",
+        "source": "UniProt:P28221",
+        "target": "UBERON:0001645"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0061370",
-        "target": "HP:0030088"
+        "key": "participates in",
+        "source": "UBERON:0001645",
+        "target": "GO:0019233"
       },
       {
         "key": "positively correlated with",
-        "source": "HP:0030088",
-        "target": "MESH:D011471"
+        "source": "GO:0019233",
+        "target": "MESH:D008881"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB05812",
+        "id": "MESH:C409045",
         "label": "Drug",
-        "name": "abiraterone acetate"
-      },
-      {
-        "id": "UniProt:P15538",
-        "label": "Protein",
-        "name": "Cytochrome P450 11B1, mitochondrial"
+        "name": "Almotriptan"
       },
       {
-        "id": "UniProt:P08686",
+        "id": "UniProt:P28222",
         "label": "Protein",
-        "name": "Steroid 21-hydroxylase"
+        "name": "5-hydroxytryptamine receptor 1B"
       },
       {
-        "id": "UniProt:P05177",
+        "id": "UniProt:P28221",
         "label": "Protein",
-        "name": "Cytochrome P450 1A2"
+        "name": "5-hydroxytryptamine receptor 1D"
       },
       {
-        "id": "UniProt:P11712",
-        "label": "Protein",
-        "name": "Cytochrome P450 2C9"
+        "id": "GO:0042310",
+        "label": "BiologicalProcess",
+        "name": "Vasoconstriction"
       },
       {
-        "id": "UniProt:P08684",
-        "label": "Protein",
-        "name": "Cytochrome P450 3A4"
+        "id": "MESH:D020078",
+        "label": "Disease",
+        "name": "Neurogenic Inflammation"
       },
       {
-        "id": "GO:0006704",
-        "label": "BiologicalProcess",
-        "name": "glucocorticoid biosynthetic process"
+        "id": "UBERON:0001645",
+        "label": "GrossAnatomicalStructure",
+        "name": "Trigeminal nerve"
       },
       {
-        "id": "GO:0061370",
+        "id": "GO:0019233",
         "label": "BiologicalProcess",
-        "name": "testosterone biosynthetic process"
+        "name": "Sensory perception of pain"
       },
       {
-        "id": "HP:0030088",
-        "label": "PhenotypicFeature",
-        "name": "Increased serum testosterone level"
+        "id": "MESH:D010146",
+        "label": "Disease",
+        "name": "Pain"
       },
       {
-        "id": "MESH:D011471",
+        "id": "MESH:D008881",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Migraine"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://www.kegg.jp/entry/D09701 https://en.wikipedia.org/wiki/21-Hydroxylase#Function"
+    "reference": "https://go.drugbank.com/drugs/DB00918 https://pubmed.ncbi.nlm.nih.gov/16099727/ https://pubmed.ncbi.nlm.nih.gov/27312704/"
   },
   {
-    "comments": "In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action), abiraterone also acts as a partial antagonist of the androgen receptor (UniProt:P10275)",
     "directed": true,
     "graph": {
-      "disease": "Malignant tumor of prostate",
-      "disease_mesh": "MESH:D011471",
-      "drug": "abiraterone acetate",
-      "drug_mesh": "MESH:D000069501,MESH:C089740",
-      "drugbank": "DB:DB05812"
+      "disease": "Onychomycosis due to dermatophyte",
+      "disease_mesh": "MESH:D014009",
+      "drug": "tavaborole",
+      "drug_mesh": "MESH:C512998",
+      "drugbank": "DB:DB09041"
     },
     "links": [
       {
         "key": "decreases activity of",
-        "source": "DB:DB05812",
-        "target": "UniProt:P10275"
+        "source": "MESH:C512998",
+        "target": "UniProt:Q9HGT2"
       },
       {
         "key": "positively regulates",
-        "source": "UniProt:P10275",
-        "target": "GO:0060769"
+        "source": "UniProt:Q9HGT2",
+        "target": "GO:0006412"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0060769",
-        "target": "MESH:D011471"
+        "key": "occurs in",
+        "source": "GO:0006412",
+        "target": "NCBITaxon:5551"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:5551",
+        "target": "MESH:D014009"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "DB:DB05812",
+        "id": "MESH:C512998",
         "label": "Drug",
-        "name": "abiraterone acetate"
+        "name": "Tavaborole"
       },
       {
-        "id": "UniProt:P10275",
+        "id": "UniProt:Q9HGT2",
         "label": "Protein",
-        "name": "Androgen receptor"
+        "name": "Cytosolic leucyl-tRNA synthetase"
       },
       {
-        "id": "GO:0060769",
+        "id": "GO:0006412",
         "label": "BiologicalProcess",
-        "name": "positive regulation of epithelial cell proliferation involved in prostate gland development"
+        "name": "Protein biosynthesis"
       },
       {
-        "id": "MESH:D011471",
+        "id": "NCBITaxon:5551",
+        "label": "OrganismTaxon",
+        "name": "Trichophyton rubrum"
+      },
+      {
+        "id": "MESH:D014009",
         "label": "Disease",
-        "name": "Malignant tumor of prostate"
+        "name": "Onychomycosis due to dermatophyte"
       }
     ],
-    "reference": "https://en.wikipedia.org/wiki/Abiraterone_acetate#Pharmacology https://en.wikipedia.org/wiki/Androgen_receptor#Mechanism_of_action https://en.wikipedia.org/wiki/Androgen_deprivation_therapy#Methods_based_on_drugs https://www.kegg.jp/entry/D09701"
+    "reference": "https://go.drugbank.com/drugs/DB09041#BE0002395 https://en.wikipedia.org/wiki/Onychomycosis"
   },
   {
-    "comments": "DrugBank has this drug as a beta 1 antagonist but data elsewhere does not seem to support the anatagonism role (e.g. https://www.drugs.com/pro/terbutaline.html#s-34090-1, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1760 https://www.genome.jp/dbget-bin/www_bget?cpd:C07129)",
     "directed": true,
     "graph": {
-      "disease": "Tear film insufficiency",
-      "disease_mesh": "MESH:D015352",
-      "drug": "terbutaline",
-      "drug_mesh": "MESH:D013726",
-      "drugbank": "DB:DB00871"
+      "disease": "Ventricular premature beats",
+      "disease_mesh": "MESH:D018879",
+      "drug": "Acebutolol",
+      "drug_mesh": "MESH:D000070",
+      "drugbank": "DB:DB01193"
     },
     "links": [
       {
-        "key": "positively regulates",
-        "source": "MESH:D013726",
-        "target": "UniProt:P13945"
+        "key": "decreases activity of",
+        "source": "MESH:D000070",
+        "target": "UniProt:P08588"
       },
       {
-        "key": "positively regulates",
-        "source": "MESH:D013726",
-        "target": "UniProt:P07550"
+        "key": "negatively regulates",
+        "source": "UniProt:P08588",
+        "target": "HP:0001649"
       },
       {
-        "key": "positively correlated with",
-        "source": "UniProt:P13945",
-        "target": "GO:0050728"
+        "key": "decreases activity of",
+        "source": "HP:0001649",
+        "target": "UniProt:P08588"
       },
       {
-        "key": "positively correlated with",
-        "source": "UniProt:P07550",
-        "target": "GO:0050728"
+        "key": "negatively regulates",
+        "source": "UniProt:P08588",
+        "target": "HP:0000822"
       },
       {
-        "key": "negatively correlated with",
-        "source": "GO:0050728",
-        "target": "MESH:D015352"
+        "key": "ameliorates",
+        "source": "HP:0001649",
+        "target": "MESH:D018879"
+      },
+      {
+        "key": "ameliorates",
+        "source": "HP:0000822",
+        "target": "MESH:D018879"
       }
     ],
     "multigraph": true,
     "nodes": [
       {
-        "id": "MESH:D013726",
+        "id": "MESH:D000070",
         "label": "Drug",
-        "name": "terbutaline"
+        "name": "Acebutolol"
       },
       {
-        "id": "UniProt:P13945",
+        "id": "UniProt:P08588",
         "label": "Protein",
-        "name": "Beta-3 adrenergic receptor"
+        "name": "Beta-1 adrenergic receptor"
       },
       {
-        "id": "UniProt:P07550",
-        "label": "Protein",
-        "name": "Beta-2 adrenergic receptor"
+        "id": "HP:0001649",
+        "label": "PhenotypicFeature",
+        "name": "heart rate"
       },
       {
-        "id": "GO:0050728",
-        "label": "BiologicalProcess",
-        "name": "negative regulation of inflammatory response"
+        "id": "HP:0000822",
+        "label": "PhenotypicFeature",
+        "name": "blood pressure"
       },
       {
-        "id": "MESH:D015352",
+        "id": "MESH:D018879",
         "label": "Disease",
-        "name": "Tear film insufficiency"
+        "name": "Ventricular premature beats"
       }
     ],
-    "reference": "https://go.drugbank.com/drugs/DB00871#mechanism-of-action https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345890/ https://europepmc.org/article/MED/23360156"
+    "reference": "https://go.drugbank.com/drugs/DB01193#mechanismofaction https://en.wikipedia.org/wiki/Acebutolol"
   },
   {
     "directed": true,
     "graph": {
-      "disease": "Malignant tumor of prostate",
-      "disease_mesh": "MESH:D011471",
-      "drug": "abiraterone acetate",
-      "drug_mesh": "MESH:D000069501,MESH:C089740",
-      "drugbank": "DB:DB05812"
+      "disease": "Diabetes mellitus type 2",
+      "disease_mesh": "MESH:D003924",
+      "drug": "Acetohexamide",
+      "drug_mesh": "MESH:D000092",
+      "drugbank": "DB:DB00414"
     },
     "links": [
       {
-        "key": "derives into",
-        "source": "DB:DB05812",
-        "target": "MESH:C000600172"
+        "key": "increases activity of",
+        "source": "MESH:D000092",
+        "target": "CL:0000169"
       },
       {
-        "key": "negatively regulates",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P05093"
+        "key": "increases secretion of",
+        "source": "CL:0000169",
+        "target": "MESH:D007328"
       },
       {
         "key": "negatively regulates",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P26439"
+        "source": "MESH:D007328",
+        "target": "MESH:D001786"
       },
       {
-        "key": "negatively regulates",
-        "source": "MESH:C000600172",
-        "target": "UniProt:P14060"
+        "key": "ameliorates",
+        "source": "MESH:D001786",
+        "target": "MESH:D003924"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D000092",
+        "label": "Drug",
+        "name": "Acetohexamide"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P05093",
-        "target": "GO:0006702"
+        "id": "CL:0000169",
+        "label": "Cell",
+        "name": "pancreatic beta cells"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P26439",
-        "target": "GO:0006702"
+        "id": "MESH:D007328",
+        "label": "ChemicalSubstance",
+        "name": "insulin"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P14060",
-        "target": "GO:0006702"
+        "id": "MESH:D001786",
+        "label": "ChemicalSubstance",
+        "name": "blood sugar"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P05093",
-        "target": "GO:0006704"
+        "id": "MESH:D003924",
+        "label": "Disease",
+        "name": "Diabetes mellitus type 2"
+      }
+    ],
+    "reference": "https://go.drugbank.com/drugs/DB00414#mechanismofaction"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Open-angle glaucoma",
+      "disease_mesh": "MESH:D005902",
+      "drug": "Apraclonidine",
+      "drug_mesh": "MESH:C016986",
+      "drugbank": "DB:DB00964"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:C016986",
+        "target": "UniProt:P08913"
       },
       {
-        "key": "positively regulates",
-        "source": "UniProt:P26439",
-        "target": "GO:0006704"
+        "key": "decreases synthesis of",
+        "source": "UniProt:P08913",
+        "target": "UBERON:0001796"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "UBERON:0001796",
+        "target": "HP:0007906"
       },
       {
         "key": "positively regulates",
-        "source": "UniProt:P14060",
-        "target": "GO:0006704"
+        "source": "UniProt:P08913",
+        "target": "GO:0045907"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0006704",
-        "target": "HP:0030088"
+        "key": "positively regulates",
+        "source": "GO:0045907",
+        "target": "HP:0012630"
       },
       {
-        "key": "positively correlated with",
-        "source": "GO:0006702",
-        "target": "HP:0030088"
+        "key": "negatively regulates",
+        "source": "HP:0012630",
+        "target": "HP:0007906"
       },
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-    "multigraph": true,
-    "nodes": [
+    "reference": "https://go.drugbank.com/drugs/DB01164#mechanismofaction https://www.aafp.org/afp/2015/0915/p487.html https://en.wikipedia.org/wiki/Hyperkalemia#:~:text=Calcium%20(calcium%20chloride%20or%20calcium,is%20elevated%20abnormally%20in%20hyperkalemia https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-dichloride#section=Pharmacology-and-Biochemistry"
+  },
+  {
+    "directed": true,
+    "graph": {
+      "disease": "Hypocalcemia",
+      "disease_mesh": "MESH:D006996",
+      "drug": "Calcium chloride",
+      "drug_mesh": "MESH:D002122",
+      "drugbank": "DB:DB01164"
+    },
+    "links": [
       {
-        "id": "MESH:C570223",
-        "label": "Drug",
-        "name": "glycerol phenylbutyrate"
+        "key": "increases abundance of",
+        "source": "MESH:D002122",
+        "target": "MESH:D002118"
       },
       {
-        "id": "CHEBI:75316",
-        "label": "ChemicalSubstance",
-        "name": "sodium phenylbutyrate"
+        "key": "located in",
+        "source": "MESH:D002118",
+        "target": "UBERON:0001969"
       },
       {
-        "id": "MESH:D010648",
-        "label": "ChemicalSubstance",
-        "name": "Phenylacetates"
+        "key": "ameliorates",
+        "source": "UBERON:0001969",
+        "target": "MESH:D006996"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D002122",
+        "label": "Drug",
+        "name": "Calcium chloride"
       },
       {
-        "id": "CHEBI:28300",
+        "id": "MESH:D002118",
         "label": "ChemicalSubstance",
-        "name": "glutamine"
+        "name": "calcium"
       },
       {
-        "id": "CHEBI:17884",
-        "label": "ChemicalSubstance",
-        "name": "N2-phenylacetyl-L-glutamine"
+        "id": "UBERON:0001969",
+        "label": "GrossAnatomicalStructure",
+        "name": "blood plasma"
       },
       {
-        "id": "MESH:D056806",
+        "id": "MESH:D006996",
         "label": "Disease",
-        "name": "Disorder of the urea cycle metabolism"
+        "name": "Hypocalcemia"
       }
     ],
-    "reference": "https://go.drugbank.com/drugs/DB08909#mechanism-of-action https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=900e7dc0-9afe-4f50-80de-90567bb78519 https://en.wikipedia.org/wiki/Sodium_phenylbutyrate#Pharmacology"
+    "reference": "https://go.drugbank.com/drugs/DB01164#mechanismofaction https://www.aafp.org/afp/2015/0915/p487.html https://en.wikipedia.org/wiki/Hyperkalemia#:~:text=Calcium%20(calcium%20chloride%20or%20calcium,is%20elevated%20abnormally%20in%20hyperkalemia https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-dichloride#section=Pharmacology-and-Biochemistry"
   }
 ]
\ No newline at end of file
diff --git a/indication_paths.yaml b/indication_paths.yaml
index feb0528ed..b3c937f4b 100644
--- a/indication_paths.yaml
+++ b/indication_paths.yaml
@@ -31433,7 +31433,7 @@
         label: Disease
         name: Respiratory tract infection
     reference: https://go.drugbank.com/drugs/DB05659
-    -   directed: true
+-   directed: true
     graph:
         disease: Rheumatoid arthritis
         disease_mesh: MESH:D001172
@@ -31705,7 +31705,8 @@
         label: Disease
         name: Psoriatic Arthritis
     reference: https://go.drugbank.com/drugs/DB00065#BE0000704
--   comment: Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action
+-   comment: Methacarbamol is a skeletal muscle relaxant with an unknown mechanism
+        of action
     directed: true
     graph:
         disease: Spasticity
@@ -32251,7 +32252,8 @@
     -   id: MESH:D008881
         label: Disease
         name: Migraine
-    reference: https://go.drugbank.com/drugs/DB00918 https://pubmed.ncbi.nlm.nih.gov/16099727/ https://pubmed.ncbi.nlm.nih.gov/27312704/
+    reference: https://go.drugbank.com/drugs/DB00918 https://pubmed.ncbi.nlm.nih.gov/16099727/
+        https://pubmed.ncbi.nlm.nih.gov/27312704/
 -   directed: true
     graph:
         disease: Onychomycosis due to dermatophyte
@@ -32268,7 +32270,7 @@
         target: GO:0006412
     -   key: occurs in
         source: GO:0006412
-        target: NCBITaxon:5551 
+        target: NCBITaxon:5551
     -   key: causes
         source: NCBITaxon:5551
         target: MESH:D014009
@@ -32283,10 +32285,2854 @@
     -   id: GO:0006412
         label: BiologicalProcess
         name: Protein biosynthesis
-    -   id: NCBITaxon:5551 
+    -   id: NCBITaxon:5551
         label: OrganismTaxon
         name: Trichophyton rubrum
     -   id: MESH:D014009
         label: Disease
         name: Onychomycosis due to dermatophyte
     reference: https://go.drugbank.com/drugs/DB09041#BE0002395 https://en.wikipedia.org/wiki/Onychomycosis
+-   directed: true
+    graph:
+        disease: Ventricular premature beats
+        disease_mesh: MESH:D018879
+        drug: Acebutolol
+        drug_mesh: MESH:D000070
+        drugbank: DB:DB01193
+    links:
+    -   key: decreases activity of
+        source: MESH:D000070
+        target: UniProt:P08588
+    -   key: negatively regulates
+        source: UniProt:P08588
+        target: HP:0001649
+    -   key: decreases activity of
+        source: HP:0001649
+        target: UniProt:P08588
+    -   key: negatively regulates
+        source: UniProt:P08588
+        target: HP:0000822
+    -   key: ameliorates
+        source: HP:0001649
+        target: MESH:D018879
+    -   key: ameliorates
+        source: HP:0000822
+        target: MESH:D018879
+    multigraph: true
+    nodes:
+    -   id: MESH:D000070
+        label: Drug
+        name: Acebutolol
+    -   id: UniProt:P08588
+        label: Protein
+        name: Beta-1 adrenergic receptor
+    -   id: HP:0001649
+        label: PhenotypicFeature
+        name: heart rate
+    -   id: HP:0000822
+        label: PhenotypicFeature
+        name: blood pressure
+    -   id: MESH:D018879
+        label: Disease
+        name: Ventricular premature beats
+    reference: https://go.drugbank.com/drugs/DB01193#mechanismofaction https://en.wikipedia.org/wiki/Acebutolol
+-   directed: true
+    graph:
+        disease: Diabetes mellitus type 2
+        disease_mesh: MESH:D003924
+        drug: Acetohexamide
+        drug_mesh: MESH:D000092
+        drugbank: DB:DB00414
+    links:
+    -   key: increases activity of
+        source: MESH:D000092
+        target: CL:0000169
+    -   key: increases secretion of
+        source: CL:0000169
+        target: MESH:D007328
+    -   key: negatively regulates
+        source: MESH:D007328
+        target: MESH:D001786
+    -   key: ameliorates
+        source: MESH:D001786
+        target: MESH:D003924
+    multigraph: true
+    nodes:
+    -   id: MESH:D000092
+        label: Drug
+        name: Acetohexamide
+    -   id: CL:0000169
+        label: Cell
+        name: pancreatic beta cells
+    -   id: MESH:D007328
+        label: ChemicalSubstance
+        name: insulin
+    -   id: MESH:D001786
+        label: ChemicalSubstance
+        name: blood sugar
+    -   id: MESH:D003924
+        label: Disease
+        name: Diabetes mellitus type 2
+    reference: https://go.drugbank.com/drugs/DB00414#mechanismofaction
+-   directed: true
+    graph:
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: Apraclonidine
+        drug_mesh: MESH:C016986
+        drugbank: DB:DB00964
+    links:
+    -   key: increases activity of
+        source: MESH:C016986
+        target: UniProt:P08913
+    -   key: decreases synthesis of
+        source: UniProt:P08913
+        target: UBERON:0001796
+    -   key: negatively regulates
+        source: UBERON:0001796
+        target: HP:0007906
+    -   key: positively regulates
+        source: UniProt:P08913
+        target: GO:0045907
+    -   key: positively regulates
+        source: GO:0045907
+        target: HP:0012630
+    -   key: negatively regulates
+        source: HP:0012630
+        target: HP:0007906
+    -   key: ameliorates
+        source: HP:0007906
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:C016986
+        label: Drug
+        name: Apraclonidine
+    -   id: UniProt:P08913
+        label: Protein
+        name: alpha2 adrenergic receptor
+    -   id: UBERON:0001796
+        label: GrossAnatomicalStructure
+        name: aqueous humor
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: intraocular pressure
+    -   id: GO:0045907
+        label: BiologicalProcess
+        name: vasoconstriction
+    -   id: HP:0012630
+        label: PhenotypicFeature
+        name: uveoscleral outflow
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: intraocular pressure
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference: https://go.drugbank.com/drugs/DB00964#mechanismofaction
+-   directed: true
+    graph:
+        disease: Peripheral T-cell lymphoma
+        disease_mesh: MESH:D016411
+        drug: Belinostat
+        drug_mesh: MESH:C487081
+        drugbank: DB:DB05015
+    links:
+    -   key: decreases activity of
+        source: MESH:C487081
+        target: InterPro:IPR000286
+    -   key: increases abundance of
+        source: InterPro:IPR000286
+        target: GO:0070577
+    -   key: decreases activity of
+        source: GO:0070577
+        target: HP:0031377
+    -   key: increases abundance of
+        source: InterPro:IPR000286
+        target: GO:0070577
+    -   key: causes
+        source: GO:0070577
+        target: GO:0071158
+    -   key: increases abundance of
+        source: InterPro:IPR000286
+        target: GO:0070577
+    -   key: negatively regulates
+        source: GO:0070577
+        target: GO:0001525
+    -   key: increases abundance of
+        source: InterPro:IPR000286
+        target: GO:0070577
+    -   key: positively regulates
+        source: GO:0070577
+        target: GO:0006915
+    -   key: correlated with
+        source: GO:0006915
+        target: MESH:D016411
+    -   key: correlated with
+        source: HP:0031377
+        target: MESH:D016411
+    -   key: correlated with
+        source: GO:0071158
+        target: MESH:D016411
+    -   key: correlated with
+        source: GO:0001525
+        target: MESH:D016411
+    multigraph: true
+    nodes:
+    -   id: MESH:C487081
+        label: Drug
+        name: Belinostat
+    -   id: InterPro:IPR000286
+        label: GeneFamily
+        name: histone deacetylase
+    -   id: GO:0070577
+        label: ChemicalSubstance
+        name: acetylated histones
+    -   id: HP:0031377
+        label: PhenotypicFeature
+        name: tumor cell proliferation
+    -   id: GO:0071158
+        label: BiologicalProcess
+        name: cell cycle arrest
+    -   id: GO:0001525
+        label: BiologicalProcess
+        name: angiogenesis
+    -   id: GO:0006915
+        label: BiologicalProcess
+        name: apoptosis
+    -   id: MESH:D016411
+        label: Disease
+        name: Peripheral T-cell lymphoma
+    reference: https://go.drugbank.com/drugs/DB05015#mechanismofaction
+-   directed: true
+    graph:
+        disease: Falciparum malaria
+        disease_mesh: MESH:D016778
+        drug: Quinine
+        drug_mesh: MESH:D011803
+        drugbank: DB:DB00468
+    links:
+    -   key: decreases activity of
+        source: MESH:D011803
+        target: UniProt:Q3ZJJ7
+    -   key: disrupts
+        reference: https://doi.org/10.1016/S0014-5793(99)01260-0
+        source: UniProt:Q3ZJJ7
+        target: InterPro:IPR002338
+    -   key: increases abundance of
+        source: InterPro:IPR002338
+        target: MESH:D006418
+    -   key: enables
+        source: MESH:D006418
+        target: GO:0008219
+    -   key: in taxon
+        source: GO:0008219
+        target: NCBITaxon:5833
+    -   key: causes
+        source: NCBITaxon:5833
+        target: MESH:D016778
+    multigraph: true
+    nodes:
+    -   id: MESH:D011803
+        label: Drug
+        name: Quinine
+    -   id: UniProt:Q3ZJJ7
+        label: Protein
+        name: heme polymerase
+    -   id: InterPro:IPR002338
+        label: GeneFamily
+        name: hemoglobin
+    -   id: MESH:D006418
+        label: ChemicalSubstance
+        name: heme
+    -   id: GO:0008219
+        label: BiologicalProcess
+        name: cell death
+    -   id: NCBITaxon:5833
+        label: OrganismTaxon
+        name: Plasmodium falciparum
+    -   id: MESH:D016778
+        label: Disease
+        name: Falciparum malaria
+    reference: https://go.drugbank.com/drugs/DB00468#mechanismofaction https://en.wikipedia.org/wiki/Quinine#Mechanism_of_action
+-   directed: true
+    graph:
+        disease: Falciparum malaria
+        disease_mesh: MESH:D016778
+        drug: Quinine
+        drug_mesh: MESH:D011803
+        drugbank: DB:DB00468
+    links:
+    -   key: negatively regulates
+        source: MESH:D011803
+        target: GO:0071897
+    -   key: negatively regulates
+        source: GO:0071897
+        target: GO:0008219
+    -   key: negatively regulates
+        source: MESH:D011803
+        target: GO:0006351
+    -   key: negatively regulates
+        source: GO:0006351
+        target: GO:0008219
+    -   key: negatively regulates
+        source: MESH:D011803
+        target: GO:0006412
+    -   key: negatively regulates
+        source: GO:0006412
+        target: GO:0008219
+    -   key: negatively regulates
+        source: MESH:D011803
+        target: REACT:R-HSA-70171
+    -   key: enables
+        source: REACT:R-HSA-70171
+        target: GO:0008219
+    -   key: in taxon
+        source: GO:0008219
+        target: NCBITaxon:5833
+    -   key: causes
+        source: NCBITaxon:5833
+        target: MESH:D016778
+    multigraph: true
+    nodes:
+    -   id: MESH:D011803
+        label: Drug
+        name: Quinine
+    -   id: GO:0071897
+        label: BiologicalProcess
+        name: DNA synthesis
+    -   id: GO:0006351
+        label: BiologicalProcess
+        name: RNA synthesis
+    -   id: GO:0006412
+        label: BiologicalProcess
+        name: protein synthesis
+    -   id: REACT:R-HSA-70171
+        label: Pathway
+        name: glycolysis
+    -   id: GO:0008219
+        label: BiologicalProcess
+        name: cell death
+    -   id: NCBITaxon:5833
+        label: OrganismTaxon
+        name: Plasmodium falciparum
+    -   id: MESH:D016778
+        label: Disease
+        name: Falciparum malaria
+    reference: https://go.drugbank.com/drugs/DB00468#mechanismofaction https://en.wikipedia.org/wiki/Quinine#Mechanism_of_action
+-   directed: true
+    graph:
+        disease: Hypertensive disorder
+        disease_mesh: MESH:D006973
+        drug: Eplerenone
+        drug_mesh: null
+        drugbank: DB:DB00700
+    links:
+    -   key: decreases activity of
+        source: DB:DB00700
+        target: UniProt:P08235
+    -   key: increases abundance of
+        source: UniProt:P08235
+        target: UniProt:P00797
+    -   key: increases abundance of
+        source: UniProt:P08235
+        target: MESH:D000450
+    -   key: decreases abundance of
+        source: UniProt:P00797
+        target: HP:0011104
+    -   key: decreases abundance of
+        source: MESH:D000450
+        target: HP:0011104
+    -   key: negatively regulates
+        source: HP:0011104
+        target: HP:0004421
+    -   key: negatively regulates
+        source: HP:0011104
+        target: HP:0005117
+    -   key: prevents
+        source: HP:0004421
+        target: MESH:D006973
+    -   key: prevents
+        source: HP:0005117
+        target: MESH:D006973
+    multigraph: true
+    nodes:
+    -   id: DB:DB00700
+        label: Drug
+        name: Eplerenone
+    -   id: UniProt:P08235
+        label: Protein
+        name: mineralocorticoid receptor
+    -   id: UniProt:P00797
+        label: Protein
+        name: plasma renin
+    -   id: MESH:D000450
+        label: ChemicalSubstance
+        name: serum aldosterone
+    -   id: HP:0011104
+        label: PhenotypicFeature
+        name: blood volume
+    -   id: HP:0005117
+        label: PhenotypicFeature
+        name: diastolic blood pressure
+    -   id: HP:0004421
+        label: PhenotypicFeature
+        name: systolic blood pressure
+    -   id: MESH:D006973
+        label: Disease
+        name: Hypertensive disorder
+    reference: https://go.drugbank.com/drugs/DB00700#mechanismofaction https://en.wikipedia.org/wiki/Eplerenone
+        DOI:10.1002/14651858.CD008996.pub2
+-   directed: true
+    graph:
+        disease: Hyperuricemia
+        disease_mesh: MESH:D033461
+        drug: Febuxostat
+        drug_mesh: MESH:D000069465
+        drugbank: DB:DB04854
+    links:
+    -   key: decreases activity of
+        source: MESH:D000069465
+        target: UniProt:P47989
+    -   key: decreases abundance of
+        source: UniProt:P47989
+        target: MESH:D014527
+    -   key: correlated with
+        source: MESH:D014527
+        target: MESH:D033461
+    multigraph: true
+    nodes:
+    -   id: MESH:D000069465
+        label: Drug
+        name: Febuxostat
+    -   id: UniProt:P47989
+        label: Protein
+        name: Xanthine dehydrogenase/oxidase
+    -   id: MESH:D014527
+        label: ChemicalSubstance
+        name: serum uric acid
+    -   id: MESH:D033461
+        label: Disease
+        name: Hyperuricemia
+    reference: https://go.drugbank.com/drugs/DB04854#mechanismofaction
+-   directed: true
+    graph:
+        disease: Glucosylceramide beta-glucosidase deficiency
+        disease_mesh: MESH:D005776
+        drug: Imiglucerase
+        drug_mesh: MESH:C090568
+        drugbank: DB:DB00053
+    links:
+    -   key: increases degradation of
+        source: MESH:C090568
+        target: MESH:D005963
+    -   key: enables
+        source: MESH:D005963
+        target: REACT:R-HSA-556833
+    -   key: prevents
+        source: REACT:R-HSA-556833
+        target: MESH:D005776
+    multigraph: true
+    nodes:
+    -   id: MESH:C090568
+        label: Drug
+        name: Imiglucerase
+    -   id: MESH:D005963
+        label: ChemicalSubstance
+        name: Glucocerebroside
+    -   id: REACT:R-HSA-556833
+        label: Pathway
+        name: membrane lipid degradation
+    -   id: MESH:D005776
+        label: Disease
+        name: Glucosylceramide beta-glucosidase deficiency
+    reference: https://go.drugbank.com/drugs/DB00053#mechanismofaction
+-   directed: true
+    graph:
+        disease: Falciparum malaria
+        disease_mesh: MESH:D016778
+        drug: Proguanil
+        drug_mesh: MESH:D002727
+        drugbank: DB:DB01131
+    links:
+    -   key: has metabolite
+        source: MESH:D002727
+        target: MESH:C026009
+    -   key: decreases activity of
+        source: MESH:C026009
+        target: UniProt:P13922
+    -   key: decreases synthesis of
+        source: UniProt:P13922
+        target: REACT:R-HSA-8956320
+    -   key: disrupts
+        source: REACT:R-HSA-8956320
+        target: GO:0071897
+    -   key: in taxon
+        source: GO:0071897
+        target: NCBITaxon:5833
+    -   key: causes
+        source: NCBITaxon:5833
+        target: MESH:D016778
+    multigraph: true
+    nodes:
+    -   id: MESH:D002727
+        label: Drug
+        name: Proguanil
+    -   id: MESH:C026009
+        label: Drug
+        name: Cycloguanil
+    -   id: UniProt:P13922
+        label: Protein
+        name: Bifunctional dihydrofolate reductase-thymidylate synthase
+    -   id: REACT:R-HSA-8956320
+        label: Pathway
+        name: purines and pyrimidines
+    -   id: GO:0071897
+        label: BiologicalProcess
+        name: DNA synthesis
+    -   id: NCBITaxon:5833
+        label: OrganismTaxon
+        name: Plasmodium falciparum
+    -   id: MESH:D016778
+        label: Disease
+        name: Falciparum malaria
+    reference: https://go.drugbank.com/drugs/DB01131#mechanismofaction
+-   directed: true
+    graph:
+        disease: Bacterial endocarditis
+        disease_mesh: MESH:D004697
+        drug: Cilastatin
+        drug_mesh: MESH:D015377
+        drugbank: DB:DB01597
+    links:
+    -   key: decreases activity of
+        source: MESH:D015377
+        target: UniProt:P16444
+    -   key: disrupts
+        source: UniProt:P16444
+        target: DB:D015378
+    -   key: negatively regulates
+        source: DB:D015378
+        target: NCBITaxon:2
+    -   key: causes
+        source: NCBITaxon:2
+        target: MESH:D004697
+    multigraph: true
+    nodes:
+    -   id: MESH:D015377
+        label: Drug
+        name: Cilastatin
+    -   id: UniProt:P16444
+        label: Protein
+        name: Dipeptidase 1
+    -   id: DB:D015378
+        label: Drug
+        name: Imipenem
+    -   id: NCBITaxon:2
+        label: OrganismTaxon
+        name: Bacteria
+    -   id: MESH:D004697
+        label: Disease
+        name: Bacterial endocarditis
+    reference: https://go.drugbank.com/drugs/DB01597#mechanismofaction
+-   directed: true
+    graph:
+        disease: Abdominal abscess
+        disease_mesh: MESH:D018784
+        drug: Cilastatin
+        drug_mesh: MESH:D015377
+        drugbank: DB:DB01597
+    links:
+    -   key: decreases activity of
+        source: MESH:D015377
+        target: UniProt:P16444
+    -   key: disrupts
+        source: UniProt:P16444
+        target: DB:D015378
+    -   key: negatively regulates
+        source: DB:D015378
+        target: NCBITaxon:2
+    -   key: causes
+        source: NCBITaxon:2
+        target: MESH:D018784
+    multigraph: true
+    nodes:
+    -   id: MESH:D015377
+        label: Drug
+        name: Cilastatin
+    -   id: UniProt:P16444
+        label: Protein
+        name: Dipeptidase 1
+    -   id: DB:D015378
+        label: Drug
+        name: Imipenem
+    -   id: NCBITaxon:2
+        label: OrganismTaxon
+        name: Bacteria
+    -   id: MESH:D018784
+        label: Disease
+        name: Abdominal abscess
+    reference: https://go.drugbank.com/drugs/DB01597#mechanismofaction
+-   directed: true
+    graph:
+        disease: Infectious disease of abdomen
+        disease_mesh: MESH:D059413
+        drug: Cilastatin
+        drug_mesh: MESH:D015377
+        drugbank: DB:DB01597
+    links:
+    -   key: decreases activity of
+        source: MESH:D015377
+        target: UniProt:P16444
+    -   key: disrupts
+        source: UniProt:P16444
+        target: DB:D015378
+    -   key: negatively regulates
+        source: DB:D015378
+        target: NCBITaxon:2
+    -   key: causes
+        source: NCBITaxon:2
+        target: MESH:D059413
+    multigraph: true
+    nodes:
+    -   id: MESH:D015377
+        label: Drug
+        name: Cilastatin
+    -   id: UniProt:P16444
+        label: Protein
+        name: Dipeptidase 1
+    -   id: DB:D015378
+        label: Drug
+        name: Imipenem
+    -   id: NCBITaxon:2
+        label: OrganismTaxon
+        name: Bacteria
+    -   id: MESH:D059413
+        label: Disease
+        name: Infectious disease of abdomen
+    reference: https://go.drugbank.com/drugs/DB01597#mechanismofaction
+-   directed: true
+    graph:
+        disease: Pneumonia due to Streptococcus
+        disease_mesh: MESH:D011018
+        drug: Cilastatin
+        drug_mesh: MESH:D015377
+        drugbank: DB:DB01597
+    links:
+    -   key: decreases activity of
+        source: MESH:D015377
+        target: UniProt:P16444
+    -   key: disrupts
+        source: UniProt:P16444
+        target: DB:D015378
+    -   key: negatively regulates
+        source: DB:D015378
+        target: NCBITaxon:1313
+    -   key: causes
+        source: NCBITaxon:1313
+        target: MESH:D011018
+    multigraph: true
+    nodes:
+    -   id: MESH:D015377
+        label: Drug
+        name: Cilastatin
+    -   id: UniProt:P16444
+        label: Protein
+        name: Dipeptidase 1
+    -   id: DB:D015378
+        label: Drug
+        name: Imipenem
+    -   id: NCBITaxon:1313
+        label: OrganismTaxon
+        name: Streptococcus pneumoniae
+    -   id: MESH:D011018
+        label: Disease
+        name: Pneumonia due to Streptococcus
+    reference: https://go.drugbank.com/drugs/DB01597#mechanismofaction
+-   directed: true
+    graph:
+        disease: Bacterial pneumonia
+        disease_mesh: MESH:D018410
+        drug: Cilastatin
+        drug_mesh: MESH:D015377
+        drugbank: DB:DB01597
+    links:
+    -   key: decreases activity of
+        source: MESH:D015377
+        target: UniProt:P16444
+    -   key: disrupts
+        source: UniProt:P16444
+        target: DB:D015378
+    -   key: negatively regulates
+        source: DB:D015378
+        target: NCBITaxon:2
+    -   key: causes
+        source: NCBITaxon:2
+        target: MESH:D018410
+    multigraph: true
+    nodes:
+    -   id: MESH:D015377
+        label: Drug
+        name: Cilastatin
+    -   id: UniProt:P16444
+        label: Protein
+        name: Dipeptidase 1
+    -   id: DB:D015378
+        label: Drug
+        name: Imipenem
+    -   id: NCBITaxon:2
+        label: OrganismTaxon
+        name: Bacteria
+    -   id: MESH:D018410
+        label: Disease
+        name: Bacterial pneumonia
+    reference: https://go.drugbank.com/drugs/DB01597#mechanismofaction
+-   directed: true
+    graph:
+        disease: Endometritis
+        disease_mesh: MESH:D004716
+        drug: Cilastatin
+        drug_mesh: MESH:D015377
+        drugbank: DB:DB01597
+    links:
+    -   key: decreases activity of
+        source: MESH:D015377
+        target: UniProt:P16444
+    -   key: disrupts
+        source: UniProt:P16444
+        target: DB:D015378
+    -   key: negatively regulates
+        source: DB:D015378
+        target: NCBITaxon:2
+    -   key: causes
+        source: NCBITaxon:2
+        target: MESH:D004716
+    multigraph: true
+    nodes:
+    -   id: MESH:D015377
+        label: Drug
+        name: Cilastatin
+    -   id: UniProt:P16444
+        label: Protein
+        name: Dipeptidase 1
+    -   id: DB:D015378
+        label: Drug
+        name: Imipenem
+    -   id: NCBITaxon:2
+        label: OrganismTaxon
+        name: Bacteria
+    -   id: MESH:D004716
+        label: Disease
+        name: Endometritis
+    reference: https://go.drugbank.com/drugs/DB01597#mechanismofaction
+-   directed: true
+    graph:
+        disease: Hypertensive disorder
+        disease_mesh: MESH:D006973
+        drug: Clonidine
+        drug_mesh: MESH:D003000
+        drugbank: DB:DB00575
+    links:
+    -   key: increases activity of
+        source: MESH:D003000
+        target: UniProt:P08913
+    -   key: coexists with
+        source: UniProt:P08913
+        target: InterPro:IPR001408
+    -   key: decreases activity of
+        source: InterPro:IPR001408
+        target: InterPro:IPR030672
+    -   key: positively regulates
+        source: InterPro:IPR030672
+        target: GO:0099104
+    -   key: causes
+        source: GO:0099104
+        target: GO:0060081
+    -   key: negatively regulates
+        source: GO:0060081
+        target: HP:0000822
+    -   key: correlated with
+        source: HP:0000822
+        target: MESH:D006973
+    multigraph: true
+    nodes:
+    -   id: MESH:D003000
+        label: Drug
+        name: Clonidine
+    -   id: UniProt:P08913
+        label: Protein
+        name: Alpha-2A adrenergic receptor
+    -   id: InterPro:IPR001408
+        label: GeneFamily
+        name: Gi protein alpha subunit
+    -   id: InterPro:IPR030672
+        label: GeneFamily
+        name: Adenylate cyclase
+    -   id: GO:0099104
+        label: MolecularActivity
+        name: opening of a potassium channel
+    -   id: GO:0060081
+        label: BiologicalProcess
+        name: hyperpolarization
+    -   id: HP:0000822
+        label: PhenotypicFeature
+        name: blood pressure
+    -   id: MESH:D006973
+        label: Disease
+        name: Hypertensive disorder
+    reference: https://go.drugbank.com/drugs/DB00575#mechanismofaction https://en.wikipedia.org/wiki/Clonidine
+        https://pubchem.ncbi.nlm.nih.gov/compound/Clonidine
+-   directed: true
+    graph:
+        disease: Hypertensive disorder
+        disease_mesh: MESH:D006973
+        drug: Clonidine
+        drug_mesh: MESH:D003000
+        drugbank: DB:DB00575
+    links:
+    -   key: increases activity of
+        source: MESH:D003000
+        target: UniProt:P08913
+    -   key: located in
+        source: UniProt:P08913
+        target: UBERON:0002298
+    -   key: decreases activity of
+        source: UBERON:0002298
+        target: GO:0003072
+    -   key: negatively regulates
+        source: GO:0003072
+        target: HP:0000822
+    -   key: correlated with
+        source: HP:0000822
+        target: MESH:D006973
+    multigraph: true
+    nodes:
+    -   id: MESH:D003000
+        label: Drug
+        name: Clonidine
+    -   id: UniProt:P08913
+        label: Protein
+        name: Alpha-2A adrenergic receptor
+    -   id: UBERON:0002298
+        label: GrossAnatomicalStructure
+        name: Brain stem
+    -   id: GO:0003072
+        label: BiologicalProcess
+        name: peripheral vascular resistance
+    -   id: HP:0000822
+        label: PhenotypicFeature
+        name: blood pressure
+    -   id: MESH:D006973
+        label: Disease
+        name: Hypertensive disorder
+    reference: https://go.drugbank.com/drugs/DB00575#mechanismofaction https://en.wikipedia.org/wiki/Clonidine
+        https://pubchem.ncbi.nlm.nih.gov/compound/Clonidine
+-   directed: true
+    graph:
+        disease: Attention deficit hyperactivity disorder
+        disease_mesh: MESH:D001289
+        drug: Clonidine
+        drug_mesh: MESH:D003000
+        drugbank: DB:DB00575
+    links:
+    -   key: increases activity of
+        source: MESH:D003000
+        target: UniProt:P08913
+    -   key: located in
+        source: UniProt:P08913
+        target: UBERON:0000451
+    -   key: prevents
+        source: UBERON:0000451
+        target: GO:0048243
+    -   key: disrupts
+        source: GO:0048243
+        target: HP:0007018
+    -   key: correlated with
+        source: HP:0007018
+        target: MESH:D001289
+    multigraph: true
+    nodes:
+    -   id: MESH:D003000
+        label: Drug
+        name: Clonidine
+    -   id: UniProt:P08913
+        label: Protein
+        name: Alpha-2A adrenergic receptor
+    -   id: UBERON:0000451
+        label: GrossAnatomicalStructure
+        name: prefrontal cortex
+    -   id: GO:0048243
+        label: BiologicalProcess
+        name: secretion of norepinephrine
+    -   id: HP:0007018
+        label: PhenotypicFeature
+        name: irrelevant attention
+    -   id: MESH:D001289
+        label: Disease
+        name: Attention deficit hyperactivity disorder
+    reference: https://go.drugbank.com/drugs/DB00575#mechanismofaction https://en.wikipedia.org/wiki/Clonidine
+        https://pubchem.ncbi.nlm.nih.gov/compound/Clonidine
+-   directed: true
+    graph:
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: Clonidine
+        drug_mesh: MESH:D003000
+        drugbank: DB:DB00575
+    links:
+    -   key: increases activity of
+        source: MESH:D003000
+        target: UniProt:P08913
+    -   key: decreases activity of
+        source: UniProt:P08913
+        target: GO:0003072
+    -   key: negatively regulates
+        source: GO:0003072
+        target: HP:0000822
+    -   key: negatively regulates
+        source: HP:0000822
+        target: HP:0007906
+    -   key: correlated with
+        source: HP:0007906
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:D003000
+        label: Drug
+        name: Clonidine
+    -   id: UniProt:P08913
+        label: Protein
+        name: Alpha-2A adrenergic receptor
+    -   id: GO:0003072
+        label: BiologicalProcess
+        name: peripheral vascular resistance
+    -   id: HP:0000822
+        label: PhenotypicFeature
+        name: blood pressure
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: intraocular pressure
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference: https://go.drugbank.com/drugs/DB00575#mechanismofaction https://en.wikipedia.org/wiki/Clonidine
+        https://pubchem.ncbi.nlm.nih.gov/compound/Clonidine
+-   directed: true
+    graph:
+        disease: Hypokalemia
+        disease_mesh: MESH:D007008
+        drug: Calcium chloride
+        drug_mesh: MESH:D002122
+        drugbank: DB:DB01164
+    links:
+    -   key: treats
+        source: MESH:D002122
+        target: MESH:D007008
+    multigraph: true
+    nodes:
+    -   id: MESH:D002122
+        label: Drug
+        name: Calcium chloride
+    -   id: MESH:D007008
+        label: Disease
+        name: Hypokalemia
+    reference: https://go.drugbank.com/drugs/DB01164#mechanismofaction https://www.aafp.org/afp/2015/0915/p487.html
+        https://en.wikipedia.org/wiki/Hyperkalemia#:~:text=Calcium%20(calcium%20chloride%20or%20calcium,is%20elevated%20abnormally%20in%20hyperkalemia
+        https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-dichloride#section=Pharmacology-and-Biochemistry
+-   directed: true
+    graph:
+        disease: Hyperkalemia
+        disease_mesh: MESH:D006947
+        drug: Calcium chloride
+        drug_mesh: MESH:D002122
+        drugbank: DB:DB01164
+    links:
+    -   key: regulates
+        source: MESH:D002122
+        target: GO:0030322
+    -   key: positively regulates
+        source: GO:0030322
+        target: GO:0010460
+    -   key: located in
+        source: GO:0010460
+        target: UBERON:0001133
+    -   key: ameliorates
+        source: UBERON:0001133
+        target: MESH:D006947
+    multigraph: true
+    nodes:
+    -   id: MESH:D002122
+        label: Drug
+        name: Calcium chloride
+    -   id: GO:0030322
+        label: BiologicalProcess
+        name: stabilization of membrane potential
+    -   id: GO:0010460
+        label: BiologicalProcess
+        name: heart rate
+    -   id: UBERON:0001133
+        label: GrossAnatomicalStructure
+        name: cardiac muscle
+    -   id: MESH:D006947
+        label: Disease
+        name: Hyperkalemia
+    reference: https://go.drugbank.com/drugs/DB01164#mechanismofaction https://www.aafp.org/afp/2015/0915/p487.html
+        https://en.wikipedia.org/wiki/Hyperkalemia#:~:text=Calcium%20(calcium%20chloride%20or%20calcium,is%20elevated%20abnormally%20in%20hyperkalemia
+        https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-dichloride#section=Pharmacology-and-Biochemistry
+-   directed: true
+    graph:
+        disease: Cardiac arrest
+        disease_mesh: MESH:D006323
+        drug: Calcium chloride
+        drug_mesh: MESH:D002122
+        drugbank: DB:DB01164
+    links:
+    -   key: positively regulates
+        source: MESH:D002122
+        target: GO:0060075
+    -   key: located in
+        source: GO:0060075
+        target: UBERON:0001133
+    -   key: correlated with
+        source: UBERON:0001133
+        target: MESH:D006323
+    multigraph: true
+    nodes:
+    -   id: MESH:D002122
+        label: Drug
+        name: Calcium chloride
+    -   id: GO:0060075
+        label: BiologicalProcess
+        name: resting membrane potential
+    -   id: UBERON:0001133
+        label: GrossAnatomicalStructure
+        name: cardiac muscle
+    -   id: MESH:D006323
+        label: Disease
+        name: Cardiac arrest
+    reference: https://go.drugbank.com/drugs/DB01164#mechanismofaction https://www.aafp.org/afp/2015/0915/p487.html
+        https://en.wikipedia.org/wiki/Hyperkalemia#:~:text=Calcium%20(calcium%20chloride%20or%20calcium,is%20elevated%20abnormally%20in%20hyperkalemia
+        https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-dichloride#section=Pharmacology-and-Biochemistry
+-   directed: true
+    graph:
+        disease: Hypocalcemia
+        disease_mesh: MESH:D006996
+        drug: Calcium chloride
+        drug_mesh: MESH:D002122
+        drugbank: DB:DB01164
+    links:
+    -   key: increases abundance of
+        source: MESH:D002122
+        target: MESH:D002118
+    -   key: located in
+        source: MESH:D002118
+        target: UBERON:0001969
+    -   key: ameliorates
+        source: UBERON:0001969
+        target: MESH:D006996
+    multigraph: true
+    nodes:
+    -   id: MESH:D002122
+        label: Drug
+        name: Calcium chloride
+    -   id: MESH:D002118
+        label: ChemicalSubstance
+        name: calcium
+    -   id: UBERON:0001969
+        label: GrossAnatomicalStructure
+        name: blood plasma
+    -   id: MESH:D006996
+        label: Disease
+        name: Hypocalcemia
+    reference: https://go.drugbank.com/drugs/DB01164#mechanismofaction https://www.aafp.org/afp/2015/0915/p487.html
+        https://en.wikipedia.org/wiki/Hyperkalemia#:~:text=Calcium%20(calcium%20chloride%20or%20calcium,is%20elevated%20abnormally%20in%20hyperkalemia
+        https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-dichloride#section=Pharmacology-and-Biochemistry
+-   directed: true
+    graph:
+        disease: Endometriosis
+        disease_mesh: MESH:D004715
+        drug: tranexamic acid
+        drug_mesh: MESH:D014148
+        drugbank: DB:DB00302
+    links:
+    -   key: negatively regulates
+        source: MESH:D014148
+        target: UniProt:P00747
+    -   key: decreases activity of
+        source: MESH:D014148
+        target: MESH:D005341
+    -   key: positively regulates
+        source: MESH:D005341
+        target: GO:0042730
+    -   key: positively regulates
+        source: UniProt:P00747
+        target: GO:0042730
+    -   key: correlated with
+        source: GO:0042730
+        target: HP:0001892
+    -   key: correlated with
+        source: GO:0042730
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D004715
+    -   key: positively correlated with
+        source: HP:0001892
+        target: MESH:D004715
+    multigraph: true
+    nodes:
+    -   id: MESH:D014148
+        label: Drug
+        name: tranexamic acid
+    -   id: UniProt:P00747
+        label: Protein
+        name: Plasminogen
+    -   id: MESH:D005341
+        label: Protein
+        name: Fibrinolysin
+    -   id: GO:0042730
+        label: BiologicalProcess
+        name: fibrinolysis
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: HP:0001892
+        label: PhenotypicFeature
+        name: Abnormal bleeding
+    -   id: MESH:D004715
+        label: Disease
+        name: Endometriosis
+    reference: https://go.drugbank.com/drugs/DB00302#mechanism-of-action https://en.wikipedia.org/wiki/Tranexamic_acid#Mechanism_of_action
+        https://pubmed.ncbi.nlm.nih.gov/32594031/
+-   directed: true
+    graph:
+        disease: Menorrhagia
+        disease_mesh: MESH:D008595
+        drug: tranexamic acid
+        drug_mesh: MESH:D014148
+        drugbank: DB:DB00302
+    links:
+    -   key: negatively regulates
+        source: MESH:D014148
+        target: UniProt:P00747
+    -   key: positively regulates
+        source: UniProt:P00747
+        target: GO:0042730
+    -   key: decreases activity of
+        source: MESH:D014148
+        target: MESH:D005341
+    -   key: positively regulates
+        source: MESH:D005341
+        target: GO:0042730
+    -   key: correlated with
+        source: GO:0042730
+        target: HP:0001892
+    -   key: positively correlated with
+        source: HP:0001892
+        target: MESH:D008595
+    multigraph: true
+    nodes:
+    -   id: MESH:D014148
+        label: Drug
+        name: tranexamic acid
+    -   id: UniProt:P00747
+        label: Protein
+        name: Plasminogen
+    -   id: MESH:D005341
+        label: Protein
+        name: Fibrinolysin
+    -   id: GO:0042730
+        label: BiologicalProcess
+        name: fibrinolysis
+    -   id: HP:0001892
+        label: PhenotypicFeature
+        name: Abnormal bleeding
+    -   id: MESH:D008595
+        label: Disease
+        name: Menorrhagia
+    reference: https://go.drugbank.com/drugs/DB00302#mechanism-of-action https://en.wikipedia.org/wiki/Tranexamic_acid#Mechanism_of_action
+-   directed: true
+    graph:
+        disease: Epilepsy
+        disease_mesh: MESH:D004827
+        drug: trimethadione
+        drug_mesh: MESH:D014293
+        drugbank: DB:DB00347
+    links:
+    -   key: decreases activity of
+        source: MESH:D014293
+        target: UniProt:O43497
+    -   key: decreases activity of
+        source: MESH:D014293
+        target: UniProt:O95180
+    -   key: decreases activity of
+        source: MESH:D014293
+        target: UniProt:Q9P0X4
+    -   key: positively regulates
+        source: UniProt:O43497
+        target: GO:0005245
+    -   key: positively regulates
+        source: UniProt:O95180
+        target: GO:0005245
+    -   key: positively regulates
+        source: UniProt:Q9P0X4
+        target: GO:0005245
+    -   key: positively correlated with
+        source: GO:0005245
+        target: GO:0014047
+    -   key: positively correlated with
+        source: GO:0005245
+        target: GO:0014051
+    -   key: negatively correlated with
+        source: GO:0014051
+        target: GO:0036277
+    -   key: negatively correlated with
+        source: GO:0014047
+        target: GO:0036277
+    -   key: negatively correlated with
+        source: GO:0036277
+        target: MESH:D004827
+    multigraph: true
+    nodes:
+    -   id: MESH:D014293
+        label: Drug
+        name: trimethadione
+    -   id: UniProt:O43497
+        label: Protein
+        name: Voltage-dependent T-type calcium channel subunit alpha-1G
+    -   id: UniProt:Q9P0X4
+        label: Protein
+        name: Voltage-dependent T-type calcium channel subunit alpha-1I
+    -   id: UniProt:O95180
+        label: Protein
+        name: Voltage-dependent T-type calcium channel subunit alpha-1H
+    -   id: GO:0005245
+        label: MolecularActivity
+        name: voltage-gated calcium channel activity
+    -   id: GO:0014047
+        label: BiologicalProcess
+        name: glutamate secretion
+    -   id: GO:0014051
+        label: BiologicalProcess
+        name: gamma-aminobutyric acid secretion
+    -   id: GO:0036277
+        label: BiologicalProcess
+        name: response to anticonvulsant
+    -   id: MESH:D004827
+        label: Disease
+        name: Epilepsy
+    reference: https://go.drugbank.com/drugs/DB00347#mechanism-of-action https://en.wikipedia.org/wiki/Anticonvulsant
+        https://www.targetvalidation.org/summary?drug=CHEMBL695
+-   comments: DrugBank (https://go.drugbank.com/drugs/DB00668) has this drug modulating
+        beta receptors but not for glaucoma. For this indication, the ligand should
+        be an antagonist (and epinephrine is an agonist instead)
+    directed: true
+    graph:
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: epinephrine
+        drug_mesh: MESH:D004837
+        drugbank: DB:DB00668
+    links:
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P35348
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P35368
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P25100
+    -   key: participates in
+        source: UniProt:P25100
+        target: "REACT:R-HSA-416476\uFEFF"
+    -   key: participates in
+        source: UniProt:P35348
+        target: "REACT:R-HSA-416476\uFEFF"
+    -   key: participates in
+        source: UniProt:P35368
+        target: "REACT:R-HSA-416476\uFEFF"
+    -   key: participates in
+        source: UniProt:P25100
+        target: "REACT:R-HSA-416482\uFEFF"
+    -   key: participates in
+        source: UniProt:P35348
+        target: "REACT:R-HSA-416482\uFEFF"
+    -   key: participates in
+        source: UniProt:P35368
+        target: "REACT:R-HSA-416482\uFEFF"
+    -   key: positively regulates
+        source: "REACT:R-HSA-416476\uFEFF"
+        target: GO:0042310
+    -   key: positively regulates
+        source: "REACT:R-HSA-416482\uFEFF"
+        target: GO:0042310
+    -   key: negatively correlated with
+        source: GO:0042310
+        target: UBERON:0001796
+    -   key: positively correlated with
+        source: UBERON:0001796
+        target: HP:0007906
+    -   key: positively correlated with
+        source: HP:0007906
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:D004837
+        label: Drug
+        name: epinephrine
+    -   id: UniProt:P35348
+        label: Protein
+        name: Alpha-1A adrenergic receptor
+    -   id: UniProt:P35368
+        label: Protein
+        name: Alpha-1B adrenergic receptor
+    -   id: UniProt:P25100
+        label: Protein
+        name: Alpha-1D adrenergic receptor
+    -   id: "REACT:R-HSA-416476\uFEFF"
+        label: Pathway
+        name: G alpha (q) signalling events
+    -   id: "REACT:R-HSA-416482\uFEFF"
+        label: Pathway
+        name: G alpha (12/13) signalling events
+    -   id: GO:0042310
+        label: BiologicalProcess
+        name: vasoconstriction
+    -   id: UBERON:0001796
+        label: GrossAnatomicalStructure
+        name: aqueous humor of eyeball
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: Ocular Hypertension
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference: https://en.wikipedia.org/wiki/Glaucoma#Medication https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL679/
+-   comments: DrugBank (https://go.drugbank.com/drugs/DB00668) has this drug modulating
+        beta receptors but not for glaucoma. For this indication, the ligand should
+        be an antagonist (and epinephrine is an agonist instead)
+    directed: true
+    graph:
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: epinephrine
+        drug_mesh: MESH:D004837
+        drugbank: DB:DB00668
+    links:
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P18089
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P08913
+    -   key: participates in
+        source: UniProt:P18089
+        target: REACT:R-HSA-418594
+    -   key: participates in
+        source: UniProt:P18089
+        target: REACT:R-HSA-418597
+    -   key: participates in
+        source: UniProt:P08913
+        target: REACT:R-HSA-418594
+    -   key: participates in
+        source: UniProt:P08913
+        target: REACT:R-HSA-418597
+    -   key: positively regulates
+        source: REACT:R-HSA-418594
+        target: GO:0042310
+    -   key: positively regulates
+        source: REACT:R-HSA-418597
+        target: GO:0042310
+    -   key: negatively correlated with
+        source: GO:0042310
+        target: UBERON:0001796
+    -   key: positively correlated with
+        source: UBERON:0001796
+        target: HP:0007906
+    -   key: positively correlated with
+        source: HP:0007906
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:D004837
+        label: Drug
+        name: epinephrine
+    -   id: UniProt:P18089
+        label: Protein
+        name: Alpha-2B adrenergic receptor
+    -   id: UniProt:P08913
+        label: Protein
+        name: Alpha-2A adrenergic receptor
+    -   id: REACT:R-HSA-418594
+        label: Pathway
+        name: G alpha (i) signalling events
+    -   id: REACT:R-HSA-418597
+        label: Pathway
+        name: G alpha (z) signalling events
+    -   id: GO:0042310
+        label: BiologicalProcess
+        name: vasoconstriction
+    -   id: UBERON:0001796
+        label: GrossAnatomicalStructure
+        name: Aqueous Humor
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: Ocular Hypertension
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference: https://en.wikipedia.org/wiki/Glaucoma#Medication https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL679/
+-   directed: true
+    graph:
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: epinephrine
+        drug_mesh: MESH:D004837
+        drugbank: DB:DB00668
+    links:
+    -   key: decreases activity of
+        source: MESH:D004837
+        target: UniProt:P08913
+    -   key: participates in
+        source: UniProt:P08913
+        target: REACT:R-HSA-5357956
+    -   key: participates in
+        source: UniProt:P08913
+        target: REACT:R-HSA-5357786
+    -   key: positively correlated with
+        source: REACT:R-HSA-5357956
+        target: MESH:D016923
+    -   key: positively correlated with
+        source: REACT:R-HSA-5357786
+        target: GO:0006915
+    -   key: occurs in
+        source: MESH:D016923
+        target: CL:0000740
+    -   key: occurs in
+        source: GO:0006915
+        target: CL:0000740
+    -   key: disrupted by
+        source: CL:0000740
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:D004837
+        label: Drug
+        name: epinephrine
+    -   id: UniProt:P08913
+        label: Protein
+        name: Tumor necrosis factor
+    -   id: REACT:R-HSA-5357956
+        label: Pathway
+        name: TNFR1-induced NFkappaB signaling pathway
+    -   id: REACT:R-HSA-5357786
+        label: Pathway
+        name: TNFR1-induced proapoptotic signaling
+    -   id: GO:0006915
+        label: BiologicalProcess
+        name: apoptotic process
+    -   id: MESH:D016923
+        label: BiologicalProcess
+        name: Cell Death
+    -   id: CL:0000740
+        label: Cell
+        name: retinal ganglion cell
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference: https://go.drugbank.com/drugs/DB00668#mechanism-of-action https://en.wikipedia.org/wiki/Retinal_ganglion_cell#Pathology
+        https://europepmc.org/article/PMC/5497582 https://europepmc.org/article/MED/32774906
+        https://www.targetvalidation.org/evidence/ENSG00000232810/EFO_0000516?view=sec:literature
+-   directed: true
+    graph:
+        disease: Anaphylaxis
+        disease_mesh: MESH:D000707
+        drug: epinephrine
+        drug_mesh: MESH:D004837
+        drugbank: DB:DB00668
+    links:
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P35348
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P35368
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P25100
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P07550
+    -   key: participates in
+        source: UniProt:P25100
+        target: "REACT:R-HSA-416476\uFEFF"
+    -   key: participates in
+        source: UniProt:P35348
+        target: "REACT:R-HSA-416476\uFEFF"
+    -   key: participates in
+        source: UniProt:P35368
+        target: "REACT:R-HSA-416476\uFEFF"
+    -   key: participates in
+        source: UniProt:P25100
+        target: "REACT:R-HSA-416482\uFEFF"
+    -   key: participates in
+        source: UniProt:P35348
+        target: "REACT:R-HSA-416482\uFEFF"
+    -   key: participates in
+        source: UniProt:P35368
+        target: "REACT:R-HSA-416482\uFEFF"
+    -   key: participates in
+        source: UniProt:P07550
+        target: "REACT:R-HSA-418555\uFEFF"
+    -   key: negatively correlated with
+        source: "REACT:R-HSA-418555\uFEFF"
+        target: GO:0006939
+    -   key: negatively correlated with
+        source: "REACT:R-HSA-418555\uFEFF"
+        target: GO:0002553
+    -   key: positively regulates
+        source: "REACT:R-HSA-416476\uFEFF"
+        target: GO:0042310
+    -   key: positively regulates
+        source: "REACT:R-HSA-416482\uFEFF"
+        target: GO:0042310
+    -   key: negatively correlated with
+        source: GO:0042310
+        target: HP:0001025
+    -   key: positively correlated with
+        source: HP:0001025
+        target: MESH:D000707
+    -   key: positively correlated with
+        source: GO:0002553
+        target: MESH:D000707
+    -   key: positively correlated with
+        source: GO:0006939
+        target: MESH:D000707
+    multigraph: true
+    nodes:
+    -   id: MESH:D004837
+        label: Drug
+        name: epinephrine
+    -   id: UniProt:P35348
+        label: Protein
+        name: Alpha-1A adrenergic receptor
+    -   id: UniProt:P35368
+        label: Protein
+        name: Alpha-1B adrenergic receptor
+    -   id: UniProt:P25100
+        label: Protein
+        name: Alpha-1D adrenergic receptor
+    -   id: UniProt:P07550
+        label: Protein
+        name: Beta-2 adrenergic receptor
+    -   id: "REACT:R-HSA-416476\uFEFF"
+        label: Pathway
+        name: G alpha (q) signalling events
+    -   id: "REACT:R-HSA-416482\uFEFF"
+        label: Pathway
+        name: G alpha (12/13) signalling events
+    -   id: "REACT:R-HSA-418555\uFEFF"
+        label: Pathway
+        name: G alpha (s) signalling events
+    -   id: GO:0042310
+        label: BiologicalProcess
+        name: vasoconstriction
+    -   id: HP:0001025
+        label: PhenotypicFeature
+        name: Urticaria
+    -   id: GO:0006939
+        label: BiologicalProcess
+        name: smooth muscle contraction
+    -   id: GO:0002553
+        label: BiologicalProcess
+        name: histamine secretion by mast cell
+    -   id: MESH:D000707
+        label: Disease
+        name: Anaphylaxis
+    reference: https://go.drugbank.com/drugs/DB00668#mechanism-of-action https://en.wikipedia.org/wiki/Adrenergic_receptor
+        https://europepmc.org/article/med/32931210 https://allergy.org.au/patients/allergy-treatment/adrenaline-for-severe-allergies
+-   directed: true
+    graph:
+        disease: Low blood pressure
+        disease_mesh: MESH:D007022
+        drug: epinephrine
+        drug_mesh: MESH:D004837
+        drugbank: DB:DB00668
+    links:
+    -   key: increases activity of
+        source: MESH:D004837
+        target: UniProt:P08588
+    -   key: participates in
+        source: UniProt:P08588
+        target: "REACT:R-HSA-418555\uFEFF"
+    -   key: positively regulates
+        source: "REACT:R-HSA-418555\uFEFF"
+        target: GO:0002027
+    -   key: positively regulates
+        source: "REACT:R-HSA-418555\uFEFF"
+        target: GO:0002026
+    -   key: positively correlated with
+        source: GO:0002027
+        target: HP:0033533
+    -   key: positively correlated with
+        source: GO:0002026
+        target: HP:0033533
+    -   key: positively correlated with
+        source: HP:0033533
+        target: MESH:D007022
+    multigraph: true
+    nodes:
+    -   id: MESH:D004837
+        label: Drug
+        name: epinephrine
+    -   id: UniProt:P08588
+        label: Protein
+        name: Beta-1 adrenergic receptor
+    -   id: "REACT:R-HSA-418555\uFEFF"
+        label: Pathway
+        name: G alpha (s) signalling events
+    -   id: GO:0002027
+        label: BiologicalProcess
+        name: regulation of heart rate
+    -   id: GO:0002026
+        label: BiologicalProcess
+        name: regulation of the force of heart contraction
+    -   id: HP:0033533
+        label: PhenotypicFeature
+        name: Increased cardiac output
+    -   id: MESH:D007022
+        label: Disease
+        name: Low blood pressure
+    reference: https://go.drugbank.com/drugs/DB00668#mechanism-of-action http://pathwaymedicine.org/Epinephrine
+        https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor https://en.wikipedia.org/wiki/Adrenergic_receptor#History
+-   comments: Tiopronin is a cystine depleting agent (MESH:D065104). Please note that
+        NCIT has a more specific term to the MESH term used in this path (D052878
+        for Urolithiasis). The NCIT ID (not listed in the path visualiser) is NCIT:C123244.
+    directed: true
+    graph:
+        disease: Cystinuria
+        disease_mesh: MESH:D003555
+        drug: epinephrine
+        drug_mesh: MESH:D008625
+        drugbank: DB:DB06823
+    links:
+    -   key: molecularly interacts with
+        source: MESH:D008625
+        target: CHEBI:17376
+    -   key: causes
+        source: CHEBI:17376
+        target: MESH:D052878
+    -   key: causes
+        source: CHEBI:17376
+        target: HP:0033067
+    -   key: positively correlated with
+        source: MESH:D052878
+        target: MESH:D003555
+    -   key: positively correlated with
+        source: HP:0033067
+        target: MESH:D003555
+    multigraph: true
+    nodes:
+    -   id: MESH:D008625
+        label: Drug
+        name: Tiopronin
+    -   id: CHEBI:17376
+        label: ChemicalSubstance
+        name: cystine
+    -   id: HP:0033067
+        label: PhenotypicFeature
+        name: Cystine crystalluria
+    -   id: MESH:D052878
+        label: PhenotypicFeature
+        name: Urolithiasis
+    -   id: MESH:D003555
+        label: Disease
+        name: Cystinuria
+    reference: https://go.drugbank.com/drugs/DB06823#mechanism-of-action https://en.wikipedia.org/wiki/Tiopronin#Uses
+        https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=494a714e-923c-cd57-df6c-12886afb265a#nlm34090-1
+-   directed: true
+    graph:
+        disease: Hypercholesterolemia
+        disease_mesh: MESH:D006937
+        drug: colesevelam
+        drug_mesh: MESH:D000069472
+        drugbank: DB:DB00930
+    links:
+    -   key: molecularly interacts with
+        source: MESH:D000069472
+        target: CHEBI:3098
+    -   key: derives from
+        source: CHEBI:3098
+        target: MESH:D002784
+    -   key: positively correlated with
+        source: MESH:D002784
+        target: MESH:D006937
+    multigraph: true
+    nodes:
+    -   id: MESH:D000069472
+        label: Drug
+        name: colesevelam
+    -   id: CHEBI:3098
+        label: ChemicalSubstance
+        name: bile acid
+    -   id: MESH:D002784
+        label: ChemicalSubstance
+        name: Cholesterol
+    -   id: MESH:D006937
+        label: Disease
+        name: Hypercholesterolemia
+    reference: Colesevelamid is a type of ion exchange resin (MESH:D007475)
+-   directed: true
+    graph:
+        disease: Atopic dermatitis
+        disease_mesh: MESH:D003876
+        drug: crisaborole
+        drug_mesh: MESH:C543085
+        drugbank: DB:DB05219
+    links:
+    -   key: negatively regulates
+        source: MESH:C543085
+        target: UniProt:P27815
+    -   key: negatively regulates
+        source: MESH:C543085
+        target: UniProt:Q07343
+    -   key: negatively regulates
+        source: MESH:C543085
+        target: UniProt:Q08493
+    -   key: negatively regulates
+        source: MESH:C543085
+        target: UniProt:Q08499
+    -   key: positively correlated with
+        source: UniProt:P27815
+        target: GO:0006198
+    -   key: positively correlated with
+        source: UniProt:Q07343
+        target: GO:0006198
+    -   key: positively correlated with
+        source: UniProt:Q08493
+        target: GO:0006198
+    -   key: positively correlated with
+        source: UniProt:Q08499
+        target: GO:0006198
+    -   key: negatively correlated with
+        source: GO:0006198
+        target: GO:0032680
+    -   key: negatively correlated with
+        source: GO:0006198
+        target: GO:0032674
+    -   key: negatively correlated with
+        source: GO:0006198
+        target: GO:0032663
+    -   key: negatively correlated with
+        source: GO:0006198
+        target: GO:0032673
+    -   key: negatively correlated with
+        source: GO:0006198
+        target: GO:0032649
+    -   key: positively correlated with
+        source: GO:0032680
+        target: GO:0006955
+    -   key: positively correlated with
+        source: GO:0032674
+        target: GO:0006955
+    -   key: positively correlated with
+        source: GO:0032663
+        target: GO:0006955
+    -   key: positively correlated with
+        source: GO:0032649
+        target: GO:0006955
+    -   key: positively correlated with
+        source: GO:0032673
+        target: GO:0006955
+    -   key: positively correlated with
+        source: GO:0032673
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0032649
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0032663
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0032674
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0032680
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006955
+        target: MESH:D003876
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D003876
+    multigraph: true
+    nodes:
+    -   id: MESH:C543085
+        label: Drug
+        name: crisaborole
+    -   id: UniProt:P27815
+        label: Protein
+        name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
+    -   id: UniProt:Q07343
+        label: Protein
+        name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
+    -   id: UniProt:Q08493
+        label: Protein
+        name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
+    -   id: UniProt:Q08499
+        label: Protein
+        name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
+    -   id: GO:0006198
+        label: BiologicalProcess
+        name: cAMP catabolic process
+    -   id: GO:0032680
+        label: BiologicalProcess
+        name: regulation of tumor necrosis factor production
+    -   id: GO:0032674
+        label: BiologicalProcess
+        name: regulation of interleukin-5 production
+    -   id: GO:0032663
+        label: BiologicalProcess
+        name: regulation of interleukin-2 production
+    -   id: GO:0032673
+        label: BiologicalProcess
+        name: regulation of interleukin-4 production
+    -   id: GO:0032649
+        label: BiologicalProcess
+        name: regulation of interferon-gamma production
+    -   id: GO:0006955
+        label: BiologicalProcess
+        name: immune response
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D003876
+        label: Disease
+        name: Atopic dermatitis
+    reference: https://go.drugbank.com/drugs/DB00930#mechanism-of-action https://en.wikipedia.org/wiki/Crisaborole#Pharmacology
+-   directed: true
+    graph:
+        disease: "Waldenstr\xF6m macroglobulinemia"
+        disease_mesh: MESH:D008258
+        drug: ibrutinib
+        drug_mesh: MESH:C551803
+        drugbank: DB:DB09053
+    links:
+    -   key: negatively regulates
+        source: MESH:C551803
+        target: UniProt:Q06187
+    -   key: positively regulates
+        source: UniProt:Q06187
+        target: GO:0050853
+    -   key: positively regulates
+        source: GO:0050853
+        target: GO:0002368
+    -   key: negatively correlated with
+        source: GO:0050853
+        target: GO:0006915
+    -   key: positively correlated with
+        source: GO:0050853
+        target: GO:0060326
+    -   key: positively correlated with
+        source: GO:0060326
+        target: MESH:D008258
+    -   key: positively correlated with
+        source: GO:0002368
+        target: MESH:D008258
+    -   key: negatively correlated with
+        source: GO:0006915
+        target: MESH:D008258
+    multigraph: true
+    nodes:
+    -   id: MESH:C551803
+        label: Drug
+        name: ibrutinib
+    -   id: UniProt:Q06187
+        label: Protein
+        name: Tyrosine-protein kinase BTK
+    -   id: GO:0050853
+        label: BiologicalProcess
+        name: B cell receptor signaling pathway
+    -   id: GO:0002368
+        label: BiologicalProcess
+        name: B cell cytokine production
+    -   id: GO:0060326
+        label: BiologicalProcess
+        name: cell chemotaxis
+    -   id: GO:0006915
+        label: BiologicalProcess
+        name: apoptotic process
+    -   id: MESH:D008258
+        label: Disease
+        name: "Waldenstr\xF6m macroglobulinemia"
+    reference: https://go.drugbank.com/drugs/DB09053#mechanism-of-action https://en.wikipedia.org/wiki/Ibrutinib#Mechanism
+        https://en.wikipedia.org/wiki/Ibrutinib#Medical_uses https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632638/
+-   directed: true
+    graph:
+        disease: Mantle cell lymphoma
+        disease_mesh: MESH:D020522
+        drug: ibrutinib
+        drug_mesh: MESH:C551803
+        drugbank: DB:DB09053
+    links:
+    -   key: negatively regulates
+        source: MESH:C551803
+        target: UniProt:Q06187
+    -   key: positively regulates
+        source: UniProt:Q06187
+        target: GO:0050853
+    -   key: positively regulates
+        source: GO:0050853
+        target: GO:0002368
+    -   key: negatively correlated with
+        source: GO:0050853
+        target: GO:0006915
+    -   key: positively correlated with
+        source: GO:0050853
+        target: GO:0060326
+    -   key: positively correlated with
+        source: GO:0060326
+        target: MESH:D020522
+    -   key: positively correlated with
+        source: GO:0002368
+        target: MESH:D020522
+    -   key: negatively correlated with
+        source: GO:0006915
+        target: MESH:D020522
+    multigraph: true
+    nodes:
+    -   id: MESH:C551803
+        label: Drug
+        name: ibrutinib
+    -   id: UniProt:Q06187
+        label: Protein
+        name: Tyrosine-protein kinase BTK
+    -   id: GO:0050853
+        label: BiologicalProcess
+        name: B cell receptor signaling pathway
+    -   id: GO:0002368
+        label: BiologicalProcess
+        name: B cell cytokine production
+    -   id: GO:0060326
+        label: BiologicalProcess
+        name: cell chemotaxis
+    -   id: GO:0006915
+        label: BiologicalProcess
+        name: apoptotic process
+    -   id: MESH:D020522
+        label: Disease
+        name: Mantle cell lymphoma
+    reference: https://go.drugbank.com/drugs/DB09053#mechanism-of-action https://en.wikipedia.org/wiki/Ibrutinib#Mechanism
+        https://en.wikipedia.org/wiki/Ibrutinib#Medical_uses https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632638/
+-   directed: true
+    graph:
+        disease: Parkinson's disease
+        disease_mesh: MESH:D010300
+        drug: selegiline
+        drug_mesh: MESH:D012642
+        drugbank: DB:DB01037
+    links:
+    -   key: negatively regulates
+        source: MESH:D012642
+        target: UniProt:P27338
+    -   key: negatively regulates
+        source: MESH:D012642
+        target: UniProt:P21397
+    -   key: positively regulates
+        source: UniProt:P27338
+        target: GO:0042420
+    -   key: positively regulates
+        source: UniProt:P21397
+        target: GO:0042420
+    -   key: decreases abundance of
+        source: GO:0042420
+        target: MESH:D004298
+    -   key: positively correlated with
+        source: MESH:D004298
+        target: GO:0001963
+    -   key: negatively correlated with
+        source: GO:0001963
+        target: MESH:D010300
+    multigraph: true
+    nodes:
+    -   id: MESH:D012642
+        label: Drug
+        name: selegiline
+    -   id: UniProt:P21397
+        label: Protein
+        name: Amine oxidase [flavin-containing] A
+    -   id: UniProt:P27338
+        label: Protein
+        name: Amine oxidase [flavin-containing] B
+    -   id: MESH:D004298
+        label: ChemicalSubstance
+        name: Dopamine
+    -   id: GO:0042420
+        label: BiologicalProcess
+        name: dopamine catabolic process
+    -   id: GO:0001963
+        label: BiologicalProcess
+        name: synaptic transmission, dopaminergic
+    -   id: MESH:D010300
+        label: Disease
+        name: Parkinson's disease
+    reference: https://go.drugbank.com/drugs/DB01037#mechanism-of-action https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#Mechanism_of_action
+-   directed: true
+    graph:
+        disease: Major depressive disorder
+        disease_mesh: MESH:D003865
+        drug: selegiline
+        drug_mesh: MESH:D012642
+        drugbank: DB:DB01037
+    links:
+    -   key: negatively regulates
+        source: MESH:D012642
+        target: UniProt:P27338
+    -   key: negatively regulates
+        source: MESH:D012642
+        target: UniProt:P21397
+    -   key: positively regulates
+        source: UniProt:P27338
+        target: GO:0042402
+    -   key: positively regulates
+        source: UniProt:P21397
+        target: GO:0042402
+    -   key: decreases abundance of
+        source: GO:0042402
+        target: MESH:D012701
+    -   key: decreases abundance of
+        source: GO:0042402
+        target: MESH:D009638
+    -   key: positively correlated with
+        source: MESH:D012701
+        target: GO:0099153
+    -   key: positively correlated with
+        source: MESH:D009638
+        target: GO:0099155
+    -   key: negatively correlated with
+        source: GO:0099153
+        target: MESH:D003865
+    -   key: negatively correlated with
+        source: GO:0099155
+        target: MESH:D003865
+    multigraph: true
+    nodes:
+    -   id: MESH:D012642
+        label: Drug
+        name: selegiline
+    -   id: UniProt:P21397
+        label: Protein
+        name: Amine oxidase [flavin-containing] A
+    -   id: UniProt:P27338
+        label: Protein
+        name: Amine oxidase [flavin-containing] B
+    -   id: GO:0042402
+        label: BiologicalProcess
+        name: cellular biogenic amine catabolic process
+    -   id: MESH:D009638
+        label: ChemicalSubstance
+        name: Norepinephrine
+    -   id: MESH:D012701
+        label: ChemicalSubstance
+        name: Serotonin
+    -   id: GO:0099153
+        label: BiologicalProcess
+        name: synaptic transmission, serotonergic
+    -   id: GO:0099155
+        label: BiologicalProcess
+        name: synaptic transmission, noradrenergic
+    -   id: MESH:D003865
+        label: Disease
+        name: Major depressive disorder
+    reference: https://go.drugbank.com/drugs/DB01037#mechanism-of-action
+-   directed: true
+    graph:
+        disease: Diabetes mellitus type 2
+        disease_mesh: MESH:D003924
+        drug: sitagliptin
+        drug_mesh: MESH:D000068900
+        drugbank: DB:DB01261
+    links:
+    -   key: negatively regulates
+        source: MESH:D000068900
+        target: UniProt:P27487
+    -   key: participates in
+        source: UniProt:P27487
+        target: REACT:R-HSA-381771
+    -   key: participates in
+        source: UniProt:P27487
+        target: REACT:R-HSA-400511
+    -   key: negatively correlated with
+        source: REACT:R-HSA-381771
+        target: MESH:D000078790
+    -   key: negatively correlated with
+        source: REACT:R-HSA-400511
+        target: MESH:D000078790
+    -   key: positively correlated with
+        source: REACT:R-HSA-381771
+        target: GO:0070091
+    -   key: positively correlated with
+        source: REACT:R-HSA-400511
+        target: GO:0070091
+    -   key: positively correlated with
+        source: GO:0070091
+        target: MESH:D003924
+    -   key: negatively correlated with
+        source: MESH:D000078790
+        target: MESH:D003924
+    multigraph: true
+    nodes:
+    -   id: MESH:D000068900
+        label: Drug
+        name: sitagliptin
+    -   id: UniProt:P27487
+        label: Protein
+        name: Dipeptidyl peptidase 4
+    -   id: REACT:R-HSA-381771
+        label: Pathway
+        name: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
+    -   id: REACT:R-HSA-400511
+        label: Pathway
+        name: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic
+            Polypeptide (GIP)
+    -   id: MESH:D000078790
+        label: BiologicalProcess
+        name: Insulin Secretion
+    -   id: GO:0070091
+        label: BiologicalProcess
+        name: glucagon secretion
+    -   id: MESH:D003924
+        label: Disease
+        name: Diabetes mellitus type 2
+    reference: https://go.drugbank.com/drugs/DB01261#mechanism-of-action https://en.wikipedia.org/wiki/Sitagliptin
+        https://en.wikipedia.org/wiki/Dipeptidyl_peptidase-4_inhibitor https://en.wikipedia.org/wiki/Incretin#Medical_uses
+        https://en.wikipedia.org/wiki/Type_2_diabetes#Pathophysiology
+-   directed: true
+    graph:
+        disease: Pulmonary arterial hypertension
+        disease_mesh: MESH:D000081029
+        drug: beraprost
+        drug_mesh: MESH:C048081
+        drugbank: DB:DB05229
+    links:
+    -   key: increases activity of
+        source: MESH:C048081
+        target: UniProt:P43119
+    -   key: positively regulates
+        source: UniProt:P43119
+        target: GO:0007204
+    -   key: negatively correlated with
+        source: GO:0007204
+        target: GO:0044557
+    -   key: negatively correlated with
+        source: GO:0007204
+        target: GO:0042311
+    -   key: negatively correlated with
+        source: GO:0042311
+        target: MESH:D000081029
+    -   key: negatively correlated with
+        source: GO:0044557
+        target: MESH:D000081029
+    multigraph: true
+    nodes:
+    -   id: MESH:C048081
+        label: Drug
+        name: beraprost
+    -   id: UniProt:P43119
+        label: Protein
+        name: Prostacyclin receptor
+    -   id: GO:0007204
+        label: BiologicalProcess
+        name: positive regulation of cytosolic calcium ion concentration
+    -   id: GO:0044557
+        label: BiologicalProcess
+        name: relaxation of smooth muscle
+    -   id: GO:0042311
+        label: BiologicalProcess
+        name: vasodilation
+    -   id: MESH:D000081029
+        label: Disease
+        name: Pulmonary arterial hypertension
+    reference: https://go.drugbank.com/drugs/DB05229#mechanism-of-action https://en.wikipedia.org/wiki/Beraprost
+-   directed: true
+    graph:
+        disease: Liposarcoma
+        disease_mesh: MESH:D008080
+        drug: eribulin
+        drug_mesh: MESH:C490954
+        drugbank: DB:DB08871
+    links:
+    -   key: negatively regulates
+        source: MESH:C490954
+        target: PR:000028799
+    -   key: positively regulates
+        source: PR:000028799
+        target: GO:0000278
+    -   key: positively regulates
+        source: PR:000028799
+        target: GO:0051225
+    -   key: negatively correlated with
+        source: GO:0000278
+        target: GO:0006915
+    -   key: negatively correlated with
+        source: GO:0051225
+        target: GO:0006915
+    -   key: positively correlated with
+        source: GO:0006915
+        target: MESH:D008080
+    multigraph: true
+    nodes:
+    -   id: MESH:C490954
+        label: Drug
+        name: eribulin
+    -   id: PR:000028799
+        label: MacromolecularComplex
+        name: Tubulin
+    -   id: GO:0000278
+        label: BiologicalProcess
+        name: mitotic cell cycle
+    -   id: GO:0051225
+        label: BiologicalProcess
+        name: spindle assembly
+    -   id: GO:0006915
+        label: BiologicalProcess
+        name: apoptotic process
+    -   id: MESH:D008080
+        label: Disease
+        name: Liposarcoma
+    reference: https://alpha.targetvalidation.org/drug/CHEMBL1683590 https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1683590/
+        https://en.wikipedia.org/wiki/Eribulin#Structure_and_mechanism https://en.wikipedia.org/wiki/Microtubule#Tubulin-binding_drugs_and_chemical_effects
+        https://go.drugbank.com/drugs/DB08871#mechanism-of-action
+-   comments: The reviewed (SwissProt) entry is Q05940 (supersedes entry available
+        on DrugBank i.e.Q99870. The Ensembl gene ID is ENSG00000165646)
+    directed: true
+    graph:
+        disease: Tardive dyskinesia
+        disease_mesh: MESH:D000071057
+        drug: valbenazine
+        drug_mesh: MESH:C000603978
+        drugbank: DB:DB11915
+    links:
+    -   key: decreases activity of
+        source: MESH:C000603978
+        target: UniProt:Q05940
+    -   key: positively regulates
+        source: UniProt:Q05940
+        target: GO:0015842
+    -   key: positively correlated with
+        source: GO:0015842
+        target: REACT:R-HSA-212676
+    -   key: positively correlated with
+        source: REACT:R-HSA-212676
+        target: MESH:D000071057
+    multigraph: true
+    nodes:
+    -   id: MESH:C000603978
+        label: Drug
+        name: valbenazine
+    -   id: UniProt:Q05940
+        label: Protein
+        name: Synaptic vesicular amine transporter
+    -   id: GO:0015842
+        label: BiologicalProcess
+        name: aminergic neurotransmitter loading into synaptic vesicle
+    -   id: REACT:R-HSA-212676
+        label: Pathway
+        name: Dopamine Neurotransmitter Release Cycle
+    -   id: MESH:D000071057
+        label: Disease
+        name: Tardive dyskinesia
+    reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2364639/ https://go.drugbank.com/drugs/DB11915#mechanism-of-action
+        https://en.wikipedia.org/wiki/Valbenazine#Mechanism_of_action
+-   directed: true
+    graph:
+        disease: Chronic myeloid leukemia
+        disease_mesh: MESH:D015464
+        drug: Radotinib
+        drug_mesh: MESH:C000606751
+        drugbank: DB:DB12323
+    links:
+    -   key: decreases activity of
+        source: MESH:C000606751
+        target: UniProt:P00519
+    -   key: decreases activity of
+        source: MESH:C000606751
+        target: MESH:D016044
+    -   key: decreases activity of
+        source: MESH:C000606751
+        target: MESH:D017479
+    -   key: positively regulates
+        source: UniProt:P00519
+        target: GO:0004713
+    -   key: positively regulates
+        source: MESH:D016044
+        target: GO:0004713
+    -   key: positively regulates
+        source: MESH:D017479
+        target: GO:0004713
+    -   key: positively correlated with
+        source: UniProt:P00519
+        target: GO:0035791
+    -   key: positively correlated with
+        source: MESH:D016044
+        target: GO:0035791
+    -   key: positively correlated with
+        source: MESH:D017479
+        target: GO:0048008
+    -   key: positively correlated with
+        source: GO:0035791
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0048008
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0004713
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0035791
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0048008
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0004713
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0035791
+        target: GO:0001525
+    -   key: positively correlated with
+        source: GO:0048008
+        target: GO:0001525
+    -   key: positively correlated with
+        source: GO:0004713
+        target: GO:0001525
+    -   key: positively correlated with
+        source: GO:0001525
+        target: MESH:D015464
+    -   key: positively correlated with
+        source: GO:0008283
+        target: MESH:D015464
+    multigraph: true
+    nodes:
+    -   id: MESH:C000606751
+        label: Drug
+        name: Radotinib
+    -   id: UniProt:P00519
+        label: Protein
+        name: Tyrosine-protein kinase ABL1
+    -   id: MESH:D016044
+        label: Protein
+        name: Fusion Proteins, bcr-abl
+    -   id: MESH:D017479
+        label: GeneFamily
+        name: Receptors, Platelet-Derived Growth Factor
+    -   id: GO:0004713
+        label: MolecularActivity
+        name: protein tyrosine kinase activity
+    -   id: GO:0035791
+        label: BiologicalProcess
+        name: platelet-derived growth factor receptor-beta signaling pathway
+    -   id: GO:0008283
+        label: BiologicalProcess
+        name: cell population proliferation
+    -   id: GO:0048008
+        label: BiologicalProcess
+        name: platelet-derived growth factor receptor signaling pathway
+    -   id: GO:0001525
+        label: BiologicalProcess
+        name: angiogenesis
+    -   id: MESH:D015464
+        label: Disease
+        name: Chronic myeloid leukemia
+    reference: https://go.drugbank.com/drugs/DB12323#mechanism-of-action https://en.wikipedia.org/wiki/Radotinib
+        https://drugcentral.org/drugcard/5188
+-   comments: note that this drug is only associated with calcium channel blockers
+        in ChEMBL (https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1008/),
+        not with potassium channel blockers (or other targets) as DrugBank has it.
+        This drug is no longer sold in the United States. It's been implicated in
+        causing ventricular arrhythmia.
+    directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:P51787
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:Q12809
+    -   key: participates in
+        source: UniProt:P51787
+        target: REACT:R-HSA-1296072
+    -   key: participates in
+        source: UniProt:P51787
+        target: REACT:R-HSA-5576890
+    -   key: participates in
+        source: UniProt:Q12809
+        target: REACT:R-HSA-1296072
+    -   key: participates in
+        source: UniProt:Q12809
+        target: REACT:R-HSA-5576890
+    -   key: positively correlated with
+        source: REACT:R-HSA-1296072
+        target: GO:0086013
+    -   key: positively correlated with
+        source: REACT:R-HSA-5576890
+        target: GO:0086013
+    -   key: negatively correlated with
+        source: GO:0086013
+        target: HP:0001657
+    -   key: positively correlated with
+        source: HP:0001657
+        target: HP:0004308
+    -   key: positively correlated with
+        source: HP:0004308
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: bepridil
+    -   id: UniProt:P51787
+        label: Protein
+        name: Potassium voltage-gated channel subfamily KQT member 1
+    -   id: UniProt:Q12809
+        label: Protein
+        name: Potassium voltage-gated channel subfamily H member 2
+    -   id: REACT:R-HSA-5576890
+        label: Pathway
+        name: Phase 3 - rapid repolarisation
+    -   id: REACT:R-HSA-1296072
+        label: Pathway
+        name: Voltage gated Potassium channels
+    -   id: GO:0086013
+        label: BiologicalProcess
+        name: membrane repolarization during cardiac muscle cell action potential
+    -   id: HP:0001657
+        label: PhenotypicFeature
+        name: Prolonged QT interval
+    -   id: HP:0004308
+        label: PhenotypicFeature
+        name: Ventricular arrhythmia
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#mechanism-of-action https://www.cvpharmacology.com/antiarrhy/potassium-blockers
+        https://pubmed.ncbi.nlm.nih.gov/1280569/
+-   comments: note that this drug is only associated with calcium channel blockers
+        in ChEMBL (https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1008/),
+        not with potassium channel blockers (or other targets) as DrugBank has it.
+        This drug is no longer sold in the United States. It's been implicated in
+        causing ventricular arrhythmia.
+    directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: decreases activity of
+        source: MESH:D015764
+        target: UniProt:P05023
+    -   key: positively regulates
+        source: UniProt:P05023
+        target: GO:0036376
+    -   key: positively correlated with
+        source: GO:0036376
+        target: GO:0070509
+    -   key: negatively correlated with
+        source: GO:0070509
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:P05023
+        label: Protein
+        name: Sodium/potassium-transporting ATPase subunit alpha-1
+    -   id: GO:0036376
+        label: BiologicalProcess
+        name: sodium ion export across plasma membrane
+    -   id: GO:0070509
+        label: BiologicalProcess
+        name: calcium ion import
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    references: https://go.drugbank.com/drugs/DB01244#BE0000732 https://www.ahajournals.org/doi/full/10.1161/01.STR.29.3.705
+-   comments: note that this drug is only associated with calcium channel blockers
+        in ChEMBL (https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1008/),
+        not with potassium channel blockers (or other targets) as DrugBank has it.
+        This drug is no longer sold in the United States. It's been implicated in
+        causing ventricular arrhythmia.
+    directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:O00555
+    -   key: positively correlated with
+        source: UniProt:O00555
+        target: GO:0070509
+    -   key: negatively correlated with
+        source: GO:0070509
+        target: GO:0042311
+    -   key: positively regulates
+        source: GO:0070509
+        target: GO:0002027
+    -   key: positively regulates
+        source: GO:0070509
+        target: GO:1903779
+    -   key: negatively correlated with
+        source: GO:0042311
+        target: MESH:D017202
+    -   key: negatively correlated with
+        source: GO:0002027
+        target: MESH:D017202
+    -   key: negatively correlated with
+        source: GO:1903779
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:O00555
+        label: Protein
+        name: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
+    -   id: GO:0070509
+        label: BiologicalProcess
+        name: calcium ion import
+    -   id: GO:0042311
+        label: BiologicalProcess
+        name: vasodilation
+    -   id: GO:0002027
+        label: BiologicalProcess
+        name: regulation of heart rate
+    -   id: GO:1903779
+        label: BiologicalProcess
+        name: regulation of cardiac conduction
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#BE0000356 https://en.wikipedia.org/wiki/Calcium_channel_blocker#Mechanism_of_action
+        https://en.wikipedia.org/wiki/Bepridil https://www.cvpharmacology.com/vasodilator/CCB
+-   comments: note that this drug is only associated with calcium channel blockers
+        in ChEMBL (https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1008/),
+        not with potassium channel blockers (or other targets) as DrugBank has it.
+        This drug is no longer sold in the United States. It's been implicated in
+        causing ventricular arrhythmia.
+    directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:O95180
+    -   key: positively correlated with
+        source: UniProt:O95180
+        target: GO:0070509
+    -   key: positively correlated with
+        source: UniProt:O95180
+        target: GO:0086046
+    -   key: positively regulates
+        source: GO:0070509
+        target: GO:0002027
+    -   key: positively regulates
+        source: GO:0086046
+        target: GO:0002027
+    -   key: negatively correlated with
+        source: GO:0002027
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:O95180
+        label: Protein
+        name: Voltage-dependent T-type calcium channel subunit alpha-1H
+    -   id: GO:0070509
+        label: BiologicalProcess
+        name: calcium ion import
+    -   id: GO:0086046
+        label: BiologicalProcess
+        name: membrane depolarization during SA node cell action potential
+    -   id: GO:0002027
+        label: BiologicalProcess
+        name: regulation of heart rate
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#BE0000864 https://en.wikipedia.org/wiki/T-type_calcium_channel
+        https://www.cvpharmacology.com/vasodilator/CCB
+-   comments: note that this drug is only associated with calcium channel blockers
+        in ChEMBL (https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1008/),
+        not with potassium channel blockers (or other targets) as DrugBank has it.
+        This drug is no longer sold in the United States. It's been implicated in
+        causing ventricular arrhythmia.
+    directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:Q9NY47
+    -   key: positively regulates
+        source: UniProt:Q9NY47
+        target: GO:1903779
+    -   key: positively correlated with
+        source: GO:1903779
+        target: GO:0002027
+    -   key: negatively correlated with
+        source: GO:0002027
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:Q9NY47
+        label: Protein
+        name: Voltage-dependent calcium channel subunit alpha-2/delta-2
+    -   id: GO:1903779
+        label: BiologicalProcess
+        name: regulation of cardiac conduction
+    -   id: GO:0002027
+        label: BiologicalProcess
+        name: regulation of heart rate
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#BE0002396 https://en.wikipedia.org/wiki/T-type_calcium_channel
+        https://www.cvpharmacology.com/vasodilator/CCB https://en.wikipedia.org/wiki/Voltage-gated_calcium_channel#%CE%B12%CE%B4_Subunit
+-   directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: positively regulates
+        source: MESH:D015764
+        target: UniProt:P63316
+    -   key: positively regulates
+        source: UniProt:P63316
+        target: GO:0055117
+    -   key: negatively correlated with
+        source: GO:0055117
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:P63316
+        label: Protein
+        name: Troponin C, slow skeletal and cardiac muscles
+    -   id: GO:0055117
+        label: BiologicalProcess
+        name: regulation of cardiac muscle contraction
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#BE0001024 https://en.wikipedia.org/wiki/Troponin_C_type_1#Troponin-binding_drugs
+-   directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:P0DP23
+    -   key: positively regulates
+        source: UniProt:P0DP23
+        target: GO:0055117
+    -   key: negatively correlated with
+        source: GO:0055117
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:P0DP23
+        label: Protein
+        name: Calmodulin-1
+    -   id: GO:0055117
+        label: BiologicalProcess
+        name: regulation of cardiac muscle contraction
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#BE0001024
+-   comments: This drug does not interact directly with the catalytic site of PDE1
+        but interact at the level of calmodulin binding sites (https://en.wikipedia.org/wiki/PDE1#Inhibitors_and_their_function)
+    directed: true
+    graph:
+        disease: Angina pectoris
+        disease_mesh: MESH:D000787
+        drug: bepridil
+        drug_mesh: MESH:D015764
+        drugbank: DB:DB01244
+    links:
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:Q01064
+    -   key: negatively regulates
+        source: MESH:D015764
+        target: UniProt:P54750
+    -   key: molecularly interacts with
+        source: UniProt:Q01064
+        target: MESH:D002147
+    -   key: molecularly interacts with
+        source: UniProt:P54750
+        target: MESH:D002147
+    -   key: positively correlated with
+        source: MESH:D002147
+        target: GO:0055117
+    -   key: negatively correlated with
+        source: GO:0055117
+        target: MESH:D017202
+    -   key: positively correlated with
+        source: MESH:D017202
+        target: MESH:D000787
+    multigraph: true
+    nodes:
+    -   id: MESH:D015764
+        label: Drug
+        name: Bepridil
+    -   id: UniProt:P54750
+        label: Protein
+        name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase
+            1A
+    -   id: UniProt:Q01064
+        label: Protein
+        name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase
+            1B
+    -   id: MESH:D002147
+        label: Protein
+        name: Calmodulin
+    -   id: GO:0055117
+        label: BiologicalProcess
+        name: regulation of cardiac muscle contraction
+    -   id: MESH:D017202
+        label: PhenotypicFeature
+        name: Myocardial Ischemia
+    -   id: MESH:D000787
+        label: Disease
+        name: Angina pectoris
+    reference: https://go.drugbank.com/drugs/DB01244#BE0003323 https://go.drugbank.com/drugs/DB01244#BE0003565
+-   directed: true
+    graph:
+        disease: Lactose intolerance
+        disease_mesh: MESH:D007787
+        drug: Tilactase
+        drug_mesh: null
+        drugbank: DB:DB13761
+    links:
+    -   key: increases degradation of
+        source: DB:DB13761
+        target: CHEBI:17716
+    -   key: has metabolite
+        source: CHEBI:17716
+        target: CHEBI:28061
+    -   key: has metabolite
+        source: CHEBI:17716
+        target: CHEBI:4167
+    -   key: positively correlated with
+        source: CHEBI:28061
+        target: GO:0050892
+    -   key: positively correlated with
+        source: CHEBI:4167
+        target: GO:0050892
+    -   key: disrupted by
+        source: GO:0050892
+        target: MESH:D007787
+    multigraph: true
+    nodes:
+    -   id: DB:DB13761
+        label: Drug
+        name: Tilactase
+    -   id: CHEBI:17716
+        label: ChemicalSubstance
+        name: Lactose
+    -   id: CHEBI:4167
+        label: ChemicalSubstance
+        name: D-glucopyranose
+    -   id: CHEBI:28061
+        label: ChemicalSubstance
+        name: "\u03B1-D-galactose"
+    -   id: GO:0050892
+        label: BiologicalProcess
+        name: intestinal absorption
+    -   id: MESH:D007787
+        label: Disease
+        name: Lactose intolerance
+    reference: https://go.drugbank.com/drugs/DB13761#mechanism-of-action
diff --git a/requirements.txt b/requirements.txt
index 5b3313116..7296e6a44 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,5 +1,6 @@
 pytest
 pandas
+pyyaml
 xlsxwriter
 xlrd==1.2.0
 simplejson
diff --git a/utils/build_indications.py b/utils/build_indications.py
index a16ad61c2..030aae3cd 100644
--- a/utils/build_indications.py
+++ b/utils/build_indications.py
@@ -6,8 +6,11 @@
 from itertools import chain
 from collections import defaultdict
 
-from test_indications import PathTester, ALLOWED_CURIS, BL_NODES, BL_PREDS
-
+# Multiple imports depending on if command line or import from script
+try:
+    from test_indications import PathTester, ALLOWED_CURIS, BL_NODES, BL_PREDS
+except ModuleNotFoundError:
+    from utils.test_indications import PathTester, ALLOWED_CURIS, BL_NODES, BL_PREDS
 
 # Define some globals for use in this script
 bl_map = pd.read_csv('utils/dmdb_to_bl_map.csv')