diff --git a/muted-tests.yml b/muted-tests.yml
index c2e7cf7faec67..f17a50ecb4068 100644
--- a/muted-tests.yml
+++ b/muted-tests.yml
@@ -400,6 +400,8 @@ tests:
 - class: org.elasticsearch.xpack.security.CoreWithSecurityClientYamlTestSuiteIT
   method: test {yaml=snapshot.delete/10_basic/Delete a snapshot asynchronously}
   issue: https://github.com/elastic/elasticsearch/issues/122104
+- class: org.elasticsearch.datastreams.TSDBPassthroughIndexingIT
+  issue: https://github.com/elastic/elasticsearch/issues/121716
 
 # Examples:
 #