diff --git a/cpu/nrf52/Makefile.dep b/cpu/nrf52/Makefile.dep
index 9503c70377c2..52a3444b4fdc 100644
--- a/cpu/nrf52/Makefile.dep
+++ b/cpu/nrf52/Makefile.dep
@@ -17,6 +17,10 @@ ifneq (,$(filter nrf802154,$(USEMODULE)))
   endif
 endif
 
+ifneq (,$(filter nrfble,$(USEMODULE)))
+  FEATURES_REQUIRED += radio_nrfble
+endif
+
 # The nrf52832 requires gpio IRQ with SPI to work around errata 58
 ifneq (,$(filter nrf52832xxaa,$(CPU_MODEL)))
   ifneq (,$(filter periph_spi,$(USEMODULE)))
diff --git a/cpu/nrf52/Makefile.nrf802154.dep b/cpu/nrf52/Makefile.nrf802154.dep
index e04fe5b154b3..a9a99e445691 100644
--- a/cpu/nrf52/Makefile.nrf802154.dep
+++ b/cpu/nrf52/Makefile.nrf802154.dep
@@ -1,5 +1,5 @@
 ifneq (,$(filter netdev_default,$(USEMODULE)))
-  ifeq (,$(filter nimble_% nrfmin,$(USEMODULE)))
+  ifeq (,$(filter nimble_% nrfmin nrfble,$(USEMODULE)))
     USEMODULE += nrf802154
   endif
 endif
diff --git a/cpu/nrf5x_common/Makefile.features b/cpu/nrf5x_common/Makefile.features
index 99043d56c4af..b8e4a24d5415 100644
--- a/cpu/nrf5x_common/Makefile.features
+++ b/cpu/nrf5x_common/Makefile.features
@@ -37,4 +37,7 @@ ifeq (,$(filter nrf9160 nrf5340_app,$(CPU_MODEL)))
   FEATURES_PROVIDED += netif
 endif
 
+FEATURES_CONFLICT += radio_nrf802154:radio_nrfble radio_nrf802154:radio_nrfmin radio_nrfble:radio_nrfmin
+FEATURES_CONFLICT_MSG += "Multiplexing the nRF radio between different radio modes is not supported."
+
 include $(RIOTCPU)/cortexm_common/Makefile.features