Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

somaticInteractions - co-occurrence data not adding up #1077

Open
kernyu opened this issue Dec 13, 2024 · 1 comment
Open

somaticInteractions - co-occurrence data not adding up #1077

kernyu opened this issue Dec 13, 2024 · 1 comment

Comments

@kernyu
Copy link

kernyu commented Dec 13, 2024

Describe the issue
I have a gene barplot of what genes are frequently seen as a co-variant with a gene of choice (DNMT3A).
DNMT3A_covariant_gene_count_001
However, when I plot co-occurrence using somaticInteractions in maftools, I find that the genes that co-occur frequently with DNMT3A are seen as slightly mutually exclusive, so I'm trying to understand how co-occurrences are calculated.
Rplot

Command
Please post your commands and the output (errors or any unexpected output)

somaticInteractions(vaf001.merged.maf, top = 5, pvalue = c(0.05, 0.1))

Session info
Run sessionInfo() and post the output below

@PoisonAlien
Copy link
Owner

Hi,

The best way is to draw an oncoplot for these 5 genes and check the pattern.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

2 participants