diff --git a/.changes/next-release/feature-Python-10095.json b/.changes/next-release/feature-Python-10095.json
new file mode 100644
index 0000000000..b52f7ffbcd
--- /dev/null
+++ b/.changes/next-release/feature-Python-10095.json
@@ -0,0 +1,5 @@
+{
+  "category": "Python", 
+  "type": "feature", 
+  "description": "Dropped support for Python 3.4 and 3.5"
+}
diff --git a/.github/workflows/run-tests.yml b/.github/workflows/run-tests.yml
index ab73ca5cf8..41d416ad54 100644
--- a/.github/workflows/run-tests.yml
+++ b/.github/workflows/run-tests.yml
@@ -13,13 +13,8 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        python-version: [2.7, 3.5, 3.6, 3.7, 3.8]
+        python-version: [2.7, 3.6, 3.7, 3.8]
         os: [ubuntu-latest, macOS-latest ]
-        include:
-          # Python 3.4 is not available on mac and windows so it needs to to
-          # be manually added to the matrix for linux.
-          - python-version: 3.4
-            os: ubuntu-latest
 
     steps:
     - uses: actions/checkout@v2
diff --git a/CONTRIBUTING.rst b/CONTRIBUTING.rst
index d1ce496ee2..9b37479129 100644
--- a/CONTRIBUTING.rst
+++ b/CONTRIBUTING.rst
@@ -44,7 +44,7 @@ contributions as well:
 * Code should follow `pep 8 <https://www.python.org/dev/peps/pep-0008/>`__,
   although if you are modifying an existing module, it is more important
   for the code to be consistent if there are any discrepancies.
-* Code must work on ``python2.7``, and ``python3.4`` and higher.
+* Code must work on ``python2.7``, and ``python3.6`` and higher.
 * Botocore is cross platform and code must work on at least linux, Windows,
   and Mac OS X.
 * If you would like to implement support for a significant feature that is not
diff --git a/README.rst b/README.rst
index 357d064f31..feda28dea9 100644
--- a/README.rst
+++ b/README.rst
@@ -14,9 +14,9 @@ botocore package is the foundation for the
 `boto3 <https://github.com/boto/boto3>`__.
 
 On 10/29/2020 deprecation for Python 3.4 and Python 3.5 was announced and support
-will be dropped on 02/01/2021. To avoid disruption, customers using Botocore
+was dropped on 02/01/2021. To avoid disruption, customers using Botocore
 on Python 3.4 or 3.5 may need to upgrade their version of Python or pin the
-version of Botocore in use prior to 02/01/2021. For more information, see
+version of Botocore. For more information, see
 this `blog post <https://aws.amazon.com/blogs/developer/announcing-the-end-of-support-for-python-3-4-and-3-5-in-the-aws-sdk-for-python-and-aws-cli-v1/>`__.
 
 Getting Started
diff --git a/setup.cfg b/setup.cfg
index ca187c2165..43b5778b56 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -5,5 +5,4 @@ universal = 1
 requires-dist =
     python-dateutil>=2.1,<3.0.0
     jmespath>=0.7.1,<1.0.0
-    urllib3>=1.25.4,<1.25.8; python_version=='3.4'
-    urllib3>=1.25.4,<1.27; python_version!='3.4'
+    urllib3>=1.25.4,<1.27
diff --git a/setup.py b/setup.py
index 373533e0cc..90d68b6c82 100644
--- a/setup.py
+++ b/setup.py
@@ -52,6 +52,7 @@ def find_version(*file_paths):
     install_requires=requires,
     extras_require={},
     license="Apache License 2.0",
+    python_requires=">= 2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, !=3.5.*",
     classifiers=[
         'Development Status :: 5 - Production/Stable',
         'Intended Audience :: Developers',
@@ -62,8 +63,6 @@ def find_version(*file_paths):
         'Programming Language :: Python :: 2',
         'Programming Language :: Python :: 2.7',
         'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.4',
-        'Programming Language :: Python :: 3.5',
         'Programming Language :: Python :: 3.6',
         'Programming Language :: Python :: 3.7',
         'Programming Language :: Python :: 3.8',
diff --git a/tox.ini b/tox.ini
index 2c4b6c7a56..a14c3a9295 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,5 @@
 [tox]
-envlist = py27,py34,py35,py36,py37,py38
+envlist = py27,py36,py37,py38
 
 skipsdist = True