diff --git a/src/ontology/doid-edit.owl b/src/ontology/doid-edit.owl
index b46cbfab4..6cb277f50 100644
--- a/src/ontology/doid-edit.owl
+++ b/src/ontology/doid-edit.owl
@@ -19278,8 +19278,8 @@ AnnotationAssertion(oboInOwl:id obo:DOID_0050567 "DOID:0050567")
 AnnotationAssertion(rdfs:comment obo:DOID_0050567 "Xref MGI.
 OMIM mapping confirmed by DO. [SN].")
 AnnotationAssertion(rdfs:label obo:DOID_0050567 "orofacial cleft")
-EquivalentClasses(obo:DOID_0050567 ObjectIntersectionOf(obo:DOID_0080015 ObjectSomeValuesFrom(obo:RO_0004019 obo:SYMP_0000462)))
 SubClassOf(obo:DOID_0050567 obo:DOID_0080015)
+SubClassOf(obo:DOID_0050567 ObjectIntersectionOf(obo:DOID_0080015 ObjectIntersectionOf(ObjectSomeValuesFrom(obo:RO_0001025 obo:DOID_0050567) ObjectSomeValuesFrom(obo:RO_0004019 obo:SYMP_0000462))))
 
 # Class: obo:DOID_0050568 (spondylocostal dysostosis)
 
@@ -72171,9 +72171,8 @@ AnnotationAssertion(oboInOwl:inSubset obo:DOID_10426 doid:NCIthesaurus)
 AnnotationAssertion(rdfs:comment obo:DOID_10426 "Xref MGI.
 OMIM mapping confirmed by DO. [SN].")
 AnnotationAssertion(rdfs:label obo:DOID_10426 "Klippel-Feil syndrome")
-EquivalentClasses(obo:DOID_10426 ObjectIntersectionOf(obo:DOID_0080015 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001130)))
 SubClassOf(obo:DOID_10426 obo:DOID_0080015)
-SubClassOf(obo:DOID_10426 ObjectSomeValuesFrom(obo:RO_0004019 obo:SYMP_0000462))
+SubClassOf(obo:DOID_10426 ObjectIntersectionOf(obo:DOID_0080015 ObjectIntersectionOf(ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001130) ObjectSomeValuesFrom(obo:RO_0004019 obo:SYMP_0000462))))
 
 # Class: obo:DOID_10428 (stable condition keratoconus)
 
@@ -110130,6 +110129,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:DOID_225 doid:DO_GXD_slim)
 AnnotationAssertion(oboInOwl:inSubset obo:DOID_225 doid:DO_MGI_slim)
 AnnotationAssertion(oboInOwl:inSubset obo:DOID_225 doid:NCIthesaurus)
 AnnotationAssertion(rdfs:label obo:DOID_225 "syndrome")
+EquivalentClasses(obo:DOID_225 ObjectIntersectionOf(obo:DOID_4 ObjectSomeValuesFrom(obo:RO_0004019 obo:SYMP_0000462)))
 SubClassOf(obo:DOID_225 obo:DOID_4)
 
 # Class: obo:DOID_2251 (hypertrophic elongation of cervix)