diff --git a/.github/workflows/testing-pipeline.yml b/.github/workflows/testing-pipeline.yml
index a8a916fa1..5d4adb2d3 100644
--- a/.github/workflows/testing-pipeline.yml
+++ b/.github/workflows/testing-pipeline.yml
@@ -116,3 +116,63 @@ jobs:
         uses: tj-actions/changed-files@v41
       - name: Check for Version Change
         run: ci/check_version_bump.py ${{ steps.get_changed_files.outputs.all_changed_and_modified_files }}
+
+  test_rqd_python_3_8:
+    name: Test RQD with python 3.8
+    runs-on: ubuntu-latest
+    container:
+      image: python:3.8
+    steps:
+      - uses: actions/checkout@v4
+      - name: Run Python Tests
+        run: ci/run_rqd_python_tests.sh
+
+  test_rqd_python_3_9:
+    name: Test RQD with python 3.9
+    runs-on: ubuntu-latest
+    container:
+      image: python:3.9
+    steps:
+      - uses: actions/checkout@v4
+      - name: Run Python Tests
+        run: ci/run_rqd_python_tests.sh
+
+  test_rqd_python_3_10:
+    name: Test RQD with python 3.10
+    runs-on: ubuntu-latest
+    container:
+      image: python:3.10
+    steps:
+      - uses: actions/checkout@v4
+      - name: Run Python Tests
+        run: ci/run_rqd_python_tests.sh
+
+  test_rqd_python_3_11:
+    name: Test RQD with python 3.11
+    runs-on: ubuntu-latest
+    container:
+      image: python:3.11
+    steps:
+      - uses: actions/checkout@v4
+      - name: Run Python Tests
+        run: ci/run_rqd_python_tests.sh
+
+  test_rqd_python_3_12:
+    name: Test RQD with python 3.12
+    runs-on: ubuntu-latest
+    container:
+      image: python:3.12
+    steps:
+      - uses: actions/checkout@v4
+      - name: Run Python Tests
+        run: ci/run_rqd_python_tests.sh
+
+  test_rqd_python_3_13:
+    name: Test RQD with python 3.13
+    runs-on: ubuntu-latest
+    container:
+      image: python:3.13
+    steps:
+      - uses: actions/checkout@v4
+      - name: Run Python Tests
+        run: ci/run_rqd_python_tests.sh
diff --git a/ci/run_rqd_python_tests.sh b/ci/run_rqd_python_tests.sh
new file mode 100755
index 000000000..1d5c2d079
--- /dev/null
+++ b/ci/run_rqd_python_tests.sh
@@ -0,0 +1,26 @@
+#!/bin/bash
+
+# Script for running OpenCue RQD unit tests with vanilla python
+#
+# This script is written to be run within the OpenCue GitHub Actions environment.
+# See `.github/workflows/testing-pipeline.yml`.
+
+set -e
+
+args=("$@")
+python_version=$(python -V 2>&1)
+echo "Will run tests using ${python_version}"
+
+pip install --user -r requirements/rqd.txt -r requirements/tests.txt
+
+# Protos need to have their Python code generated in order for tests to pass.
+python -m grpc_tools.protoc -I=proto/ --python_out=pycue/opencue/compiled_proto --grpc_python_out=pycue/opencue/compiled_proto proto/*.proto
+python -m grpc_tools.protoc -I=proto/ --python_out=rqd/rqd/compiled_proto --grpc_python_out=rqd/rqd/compiled_proto proto/*.proto
+
+# Fix imports to work in both Python 2 and 3. See
+# <https://github.com/protocolbuffers/protobuf/issues/1491> for more info.
+python ci/fix_compiled_proto.py pycue/opencue/compiled_proto
+python ci/fix_compiled_proto.py rqd/rqd/compiled_proto
+
+python -m unittest discover -s pycue/tests -t pycue -p "*.py"
+python -m pytest rqd/tests
diff --git a/requirements/rqd.txt b/requirements/rqd.txt
new file mode 100644
index 000000000..4bf32be84
--- /dev/null
+++ b/requirements/rqd.txt
@@ -0,0 +1,10 @@
+future==1.0.0
+docker==7.1.0
+grpcio==1.48.2;python_version<"3.7"
+grpcio-tools==1.48.2;python_version<"3.7"
+grpcio==1.53.2;python_version>="3.7" and python_version<"3.12"
+grpcio-tools==1.53.0;python_version>="3.7" and python_version<"3.12"
+grpcio==1.66.2;python_version>="3.12"
+grpcio-tools==1.66.2;python_version>="3.12"
+PyYAML==5.1
+psutil==5.9.8
diff --git a/requirements/tests.txt b/requirements/tests.txt
new file mode 100644
index 000000000..2ea7e1f8f
--- /dev/null
+++ b/requirements/tests.txt
@@ -0,0 +1,5 @@
+mock==2.0.0
+pyfakefs==3.6;python_version<"3.7"
+pyfakefs==5.2.3;python_version>="3.7"
+pynput==1.7.6
+pytest==8.3.3
\ No newline at end of file
diff --git a/rqd/tests/rqconstants_test.py b/rqd/tests/rqconstants_test.py
index 0503994a2..2a1553d81 100644
--- a/rqd/tests/rqconstants_test.py
+++ b/rqd/tests/rqconstants_test.py
@@ -91,7 +91,7 @@ class RqConstantTests(pyfakefs.fake_filesystem_unittest.TestCase):
     tempdir = tempfile.mkdtemp()
 
     def setUp(self):
-        self.setUpPyfakefs()
+        self.setUpPyfakefs(additional_skip_names=['shutil'])
         self.fs.add_real_directory(self.tempdir)
         self.fs.create_file("/proc/cpuinfo", contents=CPUINFO)
         self.loadavg = self.fs.create_file("/proc/loadavg", contents=LOADAVG_LOW_USAGE)